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2011 for BJID - some good news and acknowledgements
Provedor de dados: 55
Autores: Brites,Carlos.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600001

A 19-year old man with IgA vasculitis after vaccination
Provedor de dados: 55
Autores: Malek,Alexandre; Gomez-Villegas,Sara Isabel; de la Hoz,Alejandro; Nowbakht,Cima; Arias,Cesar A.
ABSTRACT A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72 h later. The diagnosis of influenza vaccine-related Henoch–Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Influenza vaccination; Immunization; IgA vasculitis; Henoch–Schonlein purpura.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500442

A case of chronic lacrimal canaliculitis: revisiting the role of Actinomyces israelii
Provedor de dados: 55
Autores: Mohanty,Srujana; Sahu,Subhrajyoti; Parija,Sucheta; Praharaj,Ashok K.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500574

A case of miltefosine responsive pleomorphic post kala-azar dermal leishmaniasis
Provedor de dados: 55
Autores: Pal,Dipankar; Naskar,Arindam; Ghosh,Manab Kumar.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500016

A case of myopericarditis associated to Campylobacter jejuni infection in the southern hemisphere
Provedor de dados: 55
Autores: Fica,Alberto; Seelmann,Daniela; Porte,Lorena; Eugenin,Daniela; Gallardo,Ricardo.
Myopericarditis is an infrequent complication of acute diarrheal illness due to Campylobacter jejuni, and it has been mainly reported in developed nations. The first case detected in Chile - an upper-middle income country -, that is coincidental with the increasing importance of acute gastroenteritis associated to this pathogen, is described. Recognition of this agent in stools requires special laboratory techniques not widely available, and it was suspected when a young patient presented with acute diarrhea, fever, and chest pain combined with electrocardiogram (EKG) abnormalities and elevated myocardial enzymes. C. jejuni myopericarditis can easily be suspected but its detection requires dedicated laboratory techniques.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Campylobacter jejuni; Myocarditis; Infectious diarrheal disease.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300014

A case of urinary tract infection caused by Raoultella planticola after a urodynamic study
Provedor de dados: 55
Autores: Tuğcu,Murat; Ruhi,Caglar; Gokce,Ali M.; Kara,Melih; Aksaray,Sebahat.
Abstract Here we report the case of a patient who developed urinary tract infection after a urodynamic study. The causative agent was Raoultella planticola, a rare opportunistic pathogen that usually invades immunocompromised patients. While a urinary tract infection with R. planticola has been previously described, this is the first report in which an R. planticola infection developed after a urodynamic study. We postulate that the mechanism of infection was direct invasion of the urinary tract from contaminated urodynamic study equipment. Here, we discuss the role played by isotonic solutions in facilitating bacterial reproduction.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Urinary tract infection; Raoultella planticola; Urodynamic study; Contamination.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200196

A case study of disseminated histoplasmosis linked to common variable immunodeficiency
Provedor de dados: 55
Autores: Rachid,Acir; Rezende,Lucila Stange; Moura,Suzelle Freitas de; Loffy,Paulo C.; Magalhães,Francisco Luiz Gomide M.
Histoplasma capsulatum, a ground fungus, can infect humans, normally in endemic areas; the resulting disease can be asymptomatic or it can have a benign development, but in rare cases it can develop into a serious clinical condition and can even be fatal. Its most characteristic initial location is in the lungs, resembling tuberculosis, often accompanied by mediastinitis and an exuberant fibrotic response. The spread of this infection can be caused by the concomitance of another illness that alters the immunological balance. Sometimes such an association is not clear. Therefore, disseminated histoplasmosis is defined as a clinical condition where the fungus is present in more than one location. Common variable immunodeficiency is characterized by a...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Disseminated histoplasmosis; Common variable immunodeficiency; Immunoglobulins.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400007

A comparative analysis between survivors and nonsurvivors patients treated with tigecycline
Provedor de dados: 55
Autores: Curcio,Daniel.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200030

A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin
Provedor de dados: 55
Autores: B. Junior,Walter; Di Chiacchio,Nilton G.; Di Chiacchio,Nilton; Romiti,Ricardo; Criado,Paulo R.; Velho,Paulo Eduardo N. Ferreira.
A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73% with azithromycin and 89% with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Azithromycin; Chancroid; Haemophilus ducreyi; Single dose; Thiamphenicol.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300012

A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers
Provedor de dados: 55
Autores: Carlesse,Fabianne; Daudt,Liane Esteves; Seber,Adriana; Dutra,Álvaro Pimenta; Melo,Analy Salles de Azevedo; Simões,Belinda; Macedo,Carla Renata Donato; Bonfim,Carmem; Benites,Eliana; Gregianin,Lauro; Batista,Marjorie Vieira; Abramczyk,Marcelo; Tostes,Vivian; Lederman,Henrique Manoel; Lee,Maria Lúcia de Martino; Loggetto,Sandra; Castro Junior,Cláudio Galvão de; Colombo,Arnaldo Lopes.
ABSTRACT In the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed the medical literature to elaborate a consensus document (CD) for the diagnosis and clinical management of invasive fungal diseases (IFDs) in children with hematologic cancer and those who underwent hematopoietic stem-cell transplantation. All major multicenter studies designed to characterize the epidemiology of IFDs in children with cancer, as well as all randomized clinical trials addressing empirical and targeted antifungal therapy were reviewed. In the absence of randomized clinical trials, the best evidence available to support the recommendations were selected. Algorithms for early...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fungal infections; Children; Cancer.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600395

A coronavirus detected in the vampire bat Desmodus rotundus
Provedor de dados: 55
Autores: Brandão,Paulo Eduardo; Scheffer,Karin; Villarreal,Laura Yaneth; Achkar,Samira; Oliveira,Rafael de Novaes; Fahl,Willian de Oliveira; Castilho,Juliana Galera; Kotait,Ivanete; Richtzenhain,Leonardo José.
This article reports on the identification of a group 2 coronavirus (BatCoV DR/2007) in a Desmodus rotundus vampire bat in Brazil. Phylogenetic analysis of ORF1b revealed that BatCoV DR/2007 originates from a unique lineage in the archetypical group 2 coronaviruses, as described for bat species elsewhere with putative importance in Public Health.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coronavirus; Vampire bat; RNA-dependent; RNA-polymerase.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600003

A cost-effectiveness analysis of two different antimicrobial stewardship programs
Provedor de dados: 55
Autores: Okumura,Lucas Miyake; Riveros,Bruno Salgado; Gomes-da-Silva,Monica Maria; Veroneze,Izelandia.
Abstract There is a lack of formal economic analysis to assess the efficiency of antimicrobial stewardship programs. Herein, we conducted a cost-effectiveness study to assess two different strategies of Antimicrobial Stewardship Programs. A 30-day Markov model was developed to analyze how cost-effective was a Bundled Antimicrobial Stewardship implemented in a university hospital in Brazil. Clinical data derived from a historical cohort that compared two different strategies of antimicrobial stewardship programs and had 30-day mortality as main outcome. Selected costs included: workload, cost of defined daily doses, length of stay, laboratory and imaging resources used to diagnose infections. Data were analyzed by deterministic and probabilistic sensitivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial stewardship program; Cost-effectiveness; Mortality; Pharmacist.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300006

A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, São Paulo, Brazil
Provedor de dados: 55
Autores: Weckx,Lily Yin; Puccini,Rosana Fiorini; Machado,Antónia; Gonçalves,Maria Gisele; Tuboi,Suely; Barros,Eliana de; Devadiga,Raghavendra; Ortega-Barria,Eduardo; Colindres,Romulo.
ABSTRACT Meningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1-24 years in Embu das Artes city, São Paulo, Brazil. Pharyngeal swabs were examined for the presence of Neisseria meningitidis. The isolates were tested for different serogroups using agglutination and polymerase chain reaction. A logistic regression model assessed any independent association between Neisseria meningitidis carriage and various risk factors. A total of 87/967 subjects (9%, 95% Confidence Interval (CI): 7.3-11.0) tested positive for N. meningitidis: 6.2% (95% CI: 3.8-9.4) in 1-4 years, 8.5% (95% CI: 5.1-13.0) in 5-9 years, 12.5% (95% CI: 7.8-18.6) in 10-14 years, 12.6% (95%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carriage; Meningococcal disease; Neisseria meningitidis; Pharyngeal; Serogroup.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600587

A cross-sectional study of isolates from sputum samples from bacterial pneumonia patients in Trinidad
Provedor de dados: 55
Autores: Nagalingam,Nabeetha A.; Adesiyun,Abiodun A.; Swanston,William H.; Bartholomew,Maria.
We determined the frequency of Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, and Gram-negative enteric bacteria (GNEB) in pneumonia patients, determined the antibiograms of these pathogens, and investigated the relationship between pneumonia and selected risk factors. Sputum and demographic data were collected from 124 pneumonia patients. Sputum was cultured for S. aureus, GNEB, H. influenzae and S. pneumoniae. The disc diffusion method was used to determine resistance to eight antimicrobial agents. Among the 124 sputum samples, eight (6.5%) were positive for S. aureus, 15 (12.1%) for GNEB, two (1.6%) for S. pneumoniae and one (0.8%) for H. influenzae. Hospitals, gender, ethnicity, co-morbidities and symptoms did not...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial pneumonia; Sputum; Antibiogram.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300006

A CssA, CssB and LTB chimeric protein induces protection against Enterotoxigenic Escherichia coli
Provedor de dados: 55
Autores: Bagheri,Samane; Gargari,Seyed Latif Mousavi; Rasooli,Iraj; Nazarian,Shahram; Alerasol,Masoome.
OBJECTIVES: Enterotoxigenic Escherichia coli (ETEC), a major cause of diarrhea in children under 5, is an important agent for traveler's diarrhea. Heat-labile enterotoxin (LT) and colonization factors (CFs) are two main virulence mechanisms in ETEC. CS6 is one of the most prevalent CFs consisting of two structural subunits viz., CssA, CssB, necessary for attachment to the intestinal cells.METHODS: In the present research, a chimeric trivalent protein composed of CssB, CssA and LTB was constructed. The chimeric gene was synthesized with codon bias of E. coli for enhanced expression of the protein. Recombinant proteins were expressed and purified. Mice were immunized with the recombinant protein. The antibody titer and specificity of the immune sera were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterotoxigenic Escherichia coli; CS6; Enterotoxin; Chimeric protein.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300308

A literature review on cardiovascular risk in human immunodeficiency virus-infected patients: implications for clinical management
Provedor de dados: 55
Autores: Gomes Neto,Mansueto; Zwirtes,Ricardo; Brites,Carlos.
INTRODUCTION: In recent years, there has been growing concern about an increasing rate of cardiovascular diseases in human immunodeficiency virus-infected patients, which could be associated with side effects of highly active antiretroviral therapy. It is likely that the metabolic disorders related to anti-human immunodeficiency virus treatment will eventually translate into a increased cardiovascular risk in patients submitted to such regimens. OBJECTIVE: To evaluate if human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy are at higher risk of cardiovascular diseases than human immunodeficiency virus infected patients not receiving highly active antiretroviral therapy, or the general population. RESEARCH DESIGN AND...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Therapeutics; Highly active antiretroviral therapy; Cardiovascular diseases.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600011

A meta-analysis of efﬁcacy and safety of doripenem for treating bacterial infections
Provedor de dados: 55
Autores: Qu,Xiao-Yu; Hu,Ting-Ting; Zhou,Wei.
Objective: The aim of this article is to compare the efﬁcacy and safety of doripenem for bacterial infections.  Methods: We included six randomized clinical trials identiﬁed from PubMed and Embase up to July 31, 2014. The included trials compared efﬁcacy and safety of doripenem for complicated intra-abdominal infections, complicated urinary tract infection, nosocomial pneumonia, and acute biliary tract infection. The meta-analysis was carried on by the statistical software of Review Manager, version 5.2.  Results: Compared with empirical antimicrobial agents on overall treatment efﬁcacy, doripenem was associated with similar clinical and microbiological treatment success rates (for the clinical evaluable population, odds ratio [OR] = 1.26, 95% conﬁdence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Doripenem Meta-analysis Efﬁcacy; Safety; Infection.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200156

A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difﬁcile infection, stratiﬁed by disease severity
Provedor de dados: 55
Autores: Di,Xiuzhen; Bai,Nan; Zhang,Xin; Liu,Bin; Ni,Wentao; Wang,Jin; Wang,Kai; Liang,Beibei; Liu,Youning; Wang,Rui.
The aim of this meta-analysis was to compare the efﬁcacy of metronidazole and vancomycin for the treatment of Clostridium difﬁcileinfection, especially to investigate which agent was superior for treating either mild or severe C. difﬁcileinfection. A meta-analysis of randomized controlled trials and cohort studies identiﬁed in Pubmed, Embase, and the Cochrane Library was conducted. Four randomized controlled trials and two cohort studies involving 1218 patients were included in this meta-analysis. Metronidazole was inferior to vancomycin for treating C. difﬁcileinfection in terms of both initial clinical cure rates (risk ratio, RR = 0.91, 95% conﬁdence interval, CI = 0.84-0.98, p= 0.02) and sustained cure rates (RR = 0.88, 95% CI = 0.82-0.96, p= 0.003)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difﬁcile; Clostridium difﬁcileinfection (CDI); Vancomycin; Metronidazole.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400339

A multicenter comparative study of cefepime versus broad-spectrum antibacterial therapy in moderate and severe bacterial infections
Provedor de dados: 55
Autores: Badaró,Roberto; Molinar,Fernando; Seas,Carlos; Stamboulian,Daniel; Mendonça,João; Massud,João; Nascimento,Luiz Olympio.
The safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated. In an open-label, multicenter study, 317 patients with an Acute Physiology and Chronic Health Evaluation (APACHE II) score ranging from &gt;5 to =19 were enrolled with documented pneumonia (n=196), urinary tract infection (n=65), intra-abdominal infection (n=38), or sepsis (n=18). Patients were randomly assigned 1:1 to receive cefepime 1 to 2 g IV twice daily or three times a day or IV ampicillin, cephalothin, or ceftriaxone ± aminoglycoside therapy for 3 to 21 days. For both treatment groups, metronidazole, vancomycin, or macrolide...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cefepime; Ampicillin; Caphalotin; Ceftriaxone; Aminoglycoside; Urinary tract infections; Intra-abdominal infections; Sepsis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500001

A new face to BJID: perspective for the near future
Provedor de dados: 55
Autores: Brites,Carlos.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100001

A non-randomized comparative study using different doses of acyclovir to prevent herpes simplex reactivation in patients submitted to autologous stem cell transplantation
Provedor de dados: 55
Autores: Atalla,Angelo; Maiolino,Angelo; Guimarães,Maria Angélica; Guimarães,Antonio Carlos; Nucci,Marcio.
The reactivation of Herpes Simplex virus (HSV) occurs in 70% to 80% of patients submitted to autologous stem cell transplantation (ASCT); it increases the severity of chemotherapy-induced mucositis. Therefore, the use of acyclovir in ASCT patients is considered standard practice. However, the minimum dose needed to prevent reactivation is a matter of debate. We compared two doses of acyclovir in a non-randomized fashion in 59 patients submitted to ASCT: 32 patients received a dose of 125 mg/m² IV every six hours and the subsequent 27 patients received a dose of 60 mg/m² IV every six hours. Viral excretion was evaluated through weekly viral culture of oral swabs. Grade 4 mucositis was more frequent in Group 1 (p= 0.03). The reactivation rates in Groups 1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acyclovir; Prophylaxis; Stem cell transplantation.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400010

A pathognomonic calcification pattern in chronic splenic brucellosis
Provedor de dados: 55
Autores: Torres,Ulysses S.; Cardoso,Luciana Vargas; D'Ippolito,Giuseppe.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600664

A pharmacodynamic strategy to optimize empirical antibiotic therapy for gram-negative bacteria in a Brazilian Intensive Care Unit
Provedor de dados: 55
Autores: Kiffer,Carlos R.V.; Kuti,Joseph L.; Mendes,Caio M.F.; Oplustil,Carmen P.; Amarante,Jorge B.; Biancalana,Maria L.; Xavier,Nelson; Nicolau,David P.
Pharmacodynamic analyses were proposed to determine optimal empirical antibiotic therapy against Gram-negative bacteria isolated in a Brazilian ICU. Due to high resistance rates, standard regimens of cefepime, ciprofloxacin, meropenem, and piperacillin/tazobactam were not able to attain significant bactericidal CFR. Prolonged infusion of meropenem achieved 88% CFR, making it a possible empirical regimen in this ICU until susceptibilities become available. Still, even through administration of high dose prolonged infusions, 12.0% of simulated subjects did not achieve bactericidal exposure, suggesting that combination therapy would frequently be required in this setting. In conclusion, we recommend that in the presence of identified resistance problems among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacodynamics; Resistance; Carbapenem; Meropenem.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200001

A prevalence study of Chlamydia infections in Turkish population
Provedor de dados: 55
Autores: Köse,Şükran; Ersan,Gürsel; Sender,Süheya Serin; Devrim,Ilker; Inal,Mehmet Murat.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100023

A prospective observational cohort study to assess the incidence of acute otitis media among children 0-5 years of age in Southern Brazil
Provedor de dados: 55
Autores: Lanzieri,Tatiana M.; Cunha,Clóvis Arns da; Cunha,Rejane B.; Arguello,D. Fermin; Devadiga,Raghavendra; Sanchez,Nervo; Barria,Eduardo Ortega.
Abstract  Objectives: To estimate acute otitis media incidence among young children and impact on quality of life of parents/caregivers in a southern Brazilian city.  Methods: Prospective cohort study including children 0-5 years of age registered at a private pediatric practice. Acute otitis media episodes diagnosed by a pediatrician and impact on quality of life of parents/caregivers were assessed during a 12-month follow-up.  Results: During September 2008-March 2010, of 1,136 children enrolled in the study, 1074 (95%) were followed: 55.0% were ≤2 years of age, 52.3% males, 94.7% white, and 69.2% had previously received pneumococcal vaccine in private clinics. Acute otitis media incidence per 1000 person-years was 95.7 (95% confidence interval:...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Acute otitis media; Children; Incidence; Quality of life.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400468

A randomized, comparative study of dual therapy (doxycycline–rifampin) versus triple therapy (doxycycline–rifampin–levofloxacin) for treating acute/subacute brucellosis
Provedor de dados: 55
Autores: Hasanain,Ahmad; Mahdy,Reem; Mohamed,Asmaa; Ali,Mostafa.
Abstract  Aim The aim of this study was to compare both the efficacy and safety profile of the WHO-recommended, dual therapy (doxycycline–rifampin) to a quinolone-based, triple therapy (doxycycline–rifampin–levofloxacin) for treating acute/subacute brucellosis.  Patients and methods We studied 107 consecutive, naïve patients with acute/subacute brucellosis admitted to Assiut University Hospital. Patients were randomly allocated to receive the dual therapy of doxycycline–rifampin (group-A) or to receive the triple therapy of doxycycline–rifampin–levofloxacin (group-B). Acute/subacute brucellosis was diagnosed based on the presence of: (1) contact with animals or fresh animal products, (2) suggestive clinical manifestations of less than one-year duration,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brucellosis; Doxycycline; Rifampin; Levofloxacin.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300005

A randomized, pilot trial comparing full versus escalating dose regimens for the desensitization of AIDS patients allergic to sulfonamides
Provedor de dados: 55
Autores: Straatmann,Andrea; Bahia,Fabianna; Pedral-Sampaio,Diana; Brites,Carlos.
Sulfonamides are drugs extensively used in the management of AIDS patients. However, the use of sulfonamides is often associated with the development of allergic reactions, provoking the substitution of the drug (by another that may be less effective); alternatively attempts are made to desensitize the patient. OBJECTIVE: Compare two drug regimens (full vs. escalating doses) for the oral desensitization of AIDS patients allergic to sulfonamides. MATERIAL AND METHODS: AIDS patients with previous allergic reactions to sulfonamides and requiring prophylaxis against Pneumocistis carinii, central nervous system toxoplasmosis and diarrhea caused by Isospora belli were randomly assigned to a group receiving a routine dose of cothrimoxazole, or another that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Allergy; Sulfonamides; Oral desensitization.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600002

A rare cause of seizures: brucellar brain abscess
Provedor de dados: 55
Autores: Yilmaz,Sanem; Avcu,Gulhadiye; Beyazal,Mehmet; Arslan,Mehmet.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300017

A rare clinical presentation of Ebstein-Barr virus
Provedor de dados: 55
Autores: Öncel,Çagatay.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200021

A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients
Provedor de dados: 55
Autores: Lanzafame,Massimiliano; Bonora,Stefano; Lattuada,Emanuela; Calcagno,Andrea; Vento,Sandro.
Darunavir (DRV) is an HIV-1 protease inhibitor that is used together with a low boosting dose of ritonavir as part of an antiretroviral therapy (ART) regimen in treatment-experienced and naïve HIVpositive patients. In naïve and experienced patients with no DRV-mutations, DRV is licensed at the dose of 800 mg plus 100 mg of ritonavir once daily. We report our results in seven ART-experienced HIV-infected patients, in whom a reduced dose of darunavir/ritonavir (600/100 mg once daily) successfully controlled viral replication
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV infections; Pharmacokinetics antiretroviral therapy; Highly active.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500017

A review of the epidemiology, prevention and treatment of human immunodeficiency virus infection in Nigeria
Provedor de dados: 55
Autores: Entonu,P.E.; Agwale,S.M.
In order to amalgamate research findings on HIV/AIDS in Nigeria as well as the trend of the infection in a concise manner, we reviewed published articles on the HIV/AIDS situation in Nigeria. We categorized this review into several subheadings. The HIV prevalence rate has continued to rise steadily from less than 0.1% in 1987, to 5.8% in 2001, with a slight decrease in 2003 to 5.0%. Although the knowledge about HIV and its mode of transmission is widespread, it is however disheartening to note that this did not result into appreciable attitudinal change and behavior modification among Nigerians. Both HIV-1 and HIV-2 have been identified in Nigeria, with HIV-1 being the predominant type. Furthermore, several subtypes like subtypes A, B, C, G and J have been...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Review; Nigeria.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600011

A search for Clostridium difficileribotypes 027 and 078 in Brazil
Provedor de dados: 55
Autores: Monteiro,Alexandre de Almeida; Pires Neto,Renata; Persson,Søren; Rodrigues Filho,Edison Moraes; Pasqualotto,Alessandro Comarú.
Toxigenic strains of Clostridium difficile may be disseminating. Here we prospectively screened patients with nosocomial diarrhoea in two hospitals in Brazil. To identify C. difficile polymerase chain reaction ribotypes 027/078 strains, we used high resolution melting and multiplex polymerase chain reaction. Among 116 screened patients, 11 were positive for C. difficile. The polymerase chain reaction ribotypes 027/078 strains were not identified in this study.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Multiplex-PCR; Clostridium difficile; HRM; Toxin gene profiling.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600672

A simple mathematical model to determine the ideal empirical antibiotic therapy for bacteremic patients
Provedor de dados: 55
Autores: Tuon,Felipe F.; Rocha,Jaime L.; Leite,Talita M.; Dias,Camila.
BACKGROUND: Local epidemiological data are always helpful when choosing the best antibiotic regimen, but it is more complex than it seems as it may require the analysis of multiple combinations. The aim of this study was to demonstrate a simplified mathematical calculation to determine the most appropriate antibiotic combination in a scenario where monotherapy is doomed to failure. METHODS: The susceptibility pattern of 11 antibiotics from 216 positive blood cultures from January 2012 to January 2013 was analyzed based on local policy. The length of hospitalization before bacteremia and the unit (ward or intensive care unit) were the analyzed variables. Bacteremia was classified as early, intermediate or late. The antibiotics were combined according to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mathematical model; Infection; Antibiotic; Bacteremia.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400360

A simple, rapid and economic method for detecting multidrug-resistant tuberculosis
Provedor de dados: 55
Autores: Wang,Xia; Jiao,Junhua; Xu,Weihua; Chai,Xiaoyan; Li,Zhenyun; Wang,Qingjiang.
OBJECTIVE: To evaluate multiplex allele specific polymerase chain reaction as a rapid molecular tool for detecting multidrug-resistant tuberculosis. METHODS: Based on drug susceptibility testing, 103 isolates were multidrug-resistant tuberculosis and 45 isolates were sensitive to isonicotinylhydrazine and rifampin. Primers were designed to target five mutations hotspots that confer resistance to the first-line drugs isoniazid and rifampin, and multiplex allele specific polymerase chain reaction was performed. Whole-genome sequencing confirmed drug resistance mutations identified by multiplex allele specific polymerase chain reaction. RESULTS: DNA sequencing revealed that 68.9% of multidrug-resistant strains have point mutations at codon 315 of the katG...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Multiplex allele specific polymerase chain reaction (MAS-PCR).
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600008

A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies
Provedor de dados: 55
Autores: Mamishi,Setareh; Eghbali,Aiden Nasiri; Rezaei,Nima; Abolhassani,Hassan; Parvaneh,Nima; Aghamohammadi,Asghar.
Primary antibody deficiencies (PADs) are a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to bacterial infections, leading to hospitalizations. This study was performed to determine the main infectious causes of hospital admissions in selective Iranian patients with PADs. Forty patients with PADs, who were admitted to the Infectious Ward of Children's Medical Center Hospital during a 14-year period, were reviewed in this study. There were 115 documented episodes of hospital admission during a 14-year period. The average length of hospital stay was 33.30 ± 25.72 days. Pneumonia was the most prominent infection leading to hospitalization among these patients (n = 48), followed by gastroenteritis (n =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infection; Hospitalization; Primary antibody deficiencies.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400007

A six-year follow-up survey of sexually transmitted diseases in Brasilia, the capital of Brazil
Provedor de dados: 55
Autores: Simões-Barbosa,Augusto; Feijó,Gilvânia Coutinho; Silva,Joaquim Xavier da; Leal,Isabel Irene Rama; Barbosa,Tânia Wanderley Paes.
The notification of sexually transmitted diseases (STD) is a prime component of well-designed public health policy. However, peculiar aspects of STD must be taken into account for the correct management of surveillance activities. Here, we describe the distribution of the most common sexually transmitted diseases among patients attended by the gynecological clinics of the principal public hospitals of Brasilia and the Federal District, Brazilian capital, during six years. A total of 142,158 patients had their cervicovaginal samples collected for Papanicolaou preparations and eventual biopsies. Diagnosis was made according to cytological and histological alterations, distinguishing among vaginal infections, and pre-cancerous and cancerous cervical lesions....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually transmitted diseases; STD notification; STD epidemiology.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300002

A strange infiltrative plaque on the face
Provedor de dados: 55
Autores: Guarneri,Claudio; Wollina,Uwe; Chokoeva,Anastasia; Lotti,Torello Maria; Tchernev,Georgi.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200214

A study of iga antibody response to different mycobacterium tuberculosis antigens in the diagnosis and monitoring of pulmonary tuberculosis
Provedor de dados: 55
Autores: Bezerra,Janaina Miranda; Beck,Sandra Trevisan; Kanunfre,Kelly Aparecida; Leite,Olavo Munhoz; Ferreira,Antônio Walter.
We evaluated the performance of the ELISA technique in the detection of IgA antibodies against different Mycobacterium tuberculosis antigenic preparations in serum samples from 49 patients with pulmonary tuberculosis collected before and after the start of specific treatment. The controls consisted of serum samples from healthy patients without any prior contact with the bacteria and serum samples from patients with other pneumopathies. Glycolipid antigen gave the best diagnostic performance, with a sensitivity of 88% and specificities varying from 88 to 100% in the control groups. These antigens constitute a powerful tool for the diagnosis and monitoring of patients with pulmonary tuberculosis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; IgA; Serological diagnosis; ELISA; Glycolipid antigen.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100012

A study of risk factors associated with the prevalence of Cryptosporidium in villages around Lake Atitlan, Guatemala
Provedor de dados: 55
Autores: Laubach,H. E.; Bentley,C. Z.; Ginter,E. L.; Spalter,J. S.; Jensen,L. A.
Cryptosporidium parvum is an endemic, zoonotic coccidian parasitosis that is highly prevalent in third-world countries where waterborne fecal contamination of food and drink or person-to-person contact with oocysts are the most common methods of transmission of the enteric protozoan. This type of transmission of the parasite made the villages around Lake Atitlan, Guatemala a unique site to compare environmental risk factors with the level of Cryptosporidium infections in the local residents. The study was carried out in two villages, San Antonio Palopo and Santa Catarina Palopo, located in the highlands above the shores of the lake. Smears from stool specimens of patients with gastroenteritis were processed using Kinyoun's modified acid-fast stain and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptosporidium; Disease transmission; Guatemala; Risk factors; Lake-water.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400008

A survey of the incidence of neonatal sepsis by group B Streptococcus during a decade in a Brazilian maternity hospital
Provedor de dados: 55
Autores: Vaciloto,Edinéia; Richtmann,Rosana; Costa,Helenilce de Paula Fiod; Kusano,Elisa Junko Ura; Almeida,Maria Fernanda Branco de; Amaro,Eduardo Rahme.
Group B Streptococcus (GBS) is the main etiological agent of neonatal sepsis in developed countries, however there is no detailed information on its incidence in Brazil. We registered the incidence and lethality of GBS infection in a Brazilian private maternity hospital from April 1991 to March 2000. Maternal risk factors contributing to neonatal infections were also scored. The rate of infection was determined by checking for GBS in the blood and liquor of symptomatic neonates within 72 hours of birth. Sepsis and/or early onset meningitis were diagnosed in 43 neonates (32 cases in blood, 1in liquor and 10 in blood and liquor). The overall incidence was 0.39 per thousand neonates and remained quite constant throughout the period, ranging from 0.25-0.63....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Newborn; Group B Streptococcus.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200001

A survey on pulmonary pathogens and their antibiotic susceptibility among cystic fibrosis patients
Provedor de dados: 55
Autores: Khanbabaee,Ghamartaj; Akbarizadeh,Majidreza; Sayyari,Aliakbar; Ashayeri-Panah,Mitra; Abdollahgorji,Fatemeh; Sheibani,Kourosh; Rezaeig,Nima.
OBJECTIVE:This study was performed to investigate frequency and antimicrobial susceptibility of pulmonary pathogens in cystic fibrosis (CF) patients. METHODS: 129 pediatric patients with CF were enrolled in this cross-sectional study. Microbiological cultures were performed based on sputum or pharyngeal swabs. Antibiotic susceptibilities of the isolated bacteria were determined by the disk diffusion method. RESULTS: The main infecting pathogens were Pseudomonas aeruginosa (38.8%), Klebsiella pneumoniae (11.6%) and Staphyloccus areus (9.3%), respectively. The most active antibiotics included rifampin (91.7% susceptibility), vancomycin (85%) and imipenem (83.5%). Emerging resistance against aminoglycosides was observed. CONCLUSION: Regarding in vitro...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cystic fibrosis; Respiratory tract; Infections; Products with antimicrobial action.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200003

A syphilis co-infection study in human papilloma virus patients attended in the sexually transmitted infection ambulatory clinic, Santa Casa de Misericórdia Hospital, Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Souza,Lúcia Maria de Sena; Miller,William Meihack; Nery,José Augusto da Costa; Andrade,Arnaldo Feitosa Braga de; Asensi,Marise Dutra.
Despite the prevalence of syphilis worldwide, little is known about its manifestations when associated with other Sexually Transmitted Infections (STI), specifically the Human Papilloma Virus (HPV). Current epidemiological studies show that there is a high incidence of both diseases in ambulatory clinics all over Brazil. This study aims to estimate the incidence of syphilis - HPV co-infections, among patients from the STI ambulatory clinic at the Santa Casa da Misericórdia Hospital, Rio de Janeiro, Brazil. Two-hundred and seven patients were seen in the clinic between March and December 2005, of which 113 (54.6%) sought care for an HPV infection. Blood samples were taken from all patients to check syphilis serology using the flocculation and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Co-infection; Syphilis; HPV; STD.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300010

A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil
Provedor de dados: 55
Autores: Duarte,Tonya Azevedo; Nery,Joilda Silva; Boechat,Neio; Pereira,Susan Martins; Simonsen,Vera; Oliveira,Martha; Gomes,Maria Gabriela Miranda; Penha-Gonçalves,Carlos; Barreto,Mauricio Lima; Barbosa,Theolis.
ABSTRACT  Introduction: The Mycobacterium tuberculosis East African-Indian (EAI) spoligotyping family (belonging to lineage 1, Indo-Oceanic, defined by the region of deletion RD239) is distributed worldwide, but is more prevalent in Southeast Asia, India, and East Africa. Studies in Latin America have rarely identified EAI. In this study, we describe the occurrence of the EAI family in Brazil.  Methods: EAI was identified in a systematic literature review of genetic diversity studies pertaining to M. tuberculosis in Brazil, as well as in a survey conducted in Salvador, Bahia, located in the northeastern region of this country.  Results: The EAI6-BGD1 spoligotyping family and the EAI5 Spoligotype International Type (SIT) 1983 clade were the most frequently...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Phylogeography; Genotyping; Epidemiology.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300317

A SYSTEMATIC REVIEW ON THE INFLUENCE OF HLA-B POLYMORPHISMS ON HIV-1 MOTHER-TO-CHILD-TRANSMISSION
Provedor de dados: 55
Autores: Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,Carlos.
ABSTRACT  Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.  Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT.  Methods: Two independent reviewers performed a systematic review on search engines PubMed, Europe PMC, Cochrane, Scientific Electronic Library Online (SciELO), and Literatura Latino-americana e do Caribe em Ciências da Saúde (Lilacs), using the following key terms: "HIV infection", "HIV newborn", "HLA polymorphisms", "HLA-B", and "Mother to child transmission". All studies focusing on evaluation of HIV-1 MTCT, HIV infection evolution, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: "Mother to child transmission"; "HIV"; "HLA-B".
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100053

Abacavir-induced liver toxicity
Provedor de dados: 55
Autores: Pezzani,Maria Diletta; Resnati,Chiara; Di Cristo,Valentina; Riva,Agostino; Gervasoni,Cristina.
Abstract Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Abacavir; Liver toxicity.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500502

Ability of Latin America laboratories to detect antimicrobial resistance patterns: experience of the SENTRY antimicrobial surveillance program (1997-2000)
Provedor de dados: 55
Autores: Mendes,Rodrigo E.; Reis,Adriana O.; Gales,Ana C.; Jones,Ronald N.; Sader,Hélio S.
The accuracy of antimicrobial susceptibility tests is a crucial step for the clinical management of patients with serious infections. They must be reliable and precise because they will guide antimicrobial therapy. Our main objective was to compare the results of susceptibility testing performed by the SENTRY coordinator laboratory with those reported by the participating Latin American medical centers. A total of 10,277 bacterial isolates were tested by the reference broth microdilution method at the coordinator laboratory in the United States. The tests were performed and interpreted following the National Committee for Clinical Laboratory Standards (NCCLS) recommendations. Ten antimicrobial agent-organism combinations were analyzed. The susceptibility...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial susceptibility test; Antimicrobial resistance pattern; Quality assurance.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500001

Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion
Provedor de dados: 55
Autores: do Socorro Nobre,Maria; Jacyntho,Claudia Marcia; Eleutério Jr,José; Giraldo,Paulo César; Gonçalves,Ana Katherine.
Abstract The purpose of this study was to assess the risk of abnormal anal cytology in women with known genital squamous intraepithelial lesion. This study evaluated 200 women with and without genital squamous intraepithelial lesion who were recruited for anal Pap smears. Women who had abnormal results on equally or over atypical squamous cells of undetermined significance were classified as having abnormal anal cytology. A multiple logistic regression analysis (stepwise) was performed to identify the risk for developing abnormal anal cytology. Data were analyzed using the SPSS 20.0 program. The average age was 41.09 (±12.64). Of the total participants, 75.5% did not practice anal sex, 91% did not have HPV-infected partners, 92% did not have any anal...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Papillomavirus; Cancer; Papanicolaou test.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300013

Absence of legionellosis in patients with community-acquired pneumonia requiring hospitalization
Provedor de dados: 55
Autores: Kühne,Juliana; Linhares,Tiago S.; Andreolla,Huander F.; Stadnik,Claudio M.B.; Pasqualotto,Alessandro C.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500572

Absence of occult hepatitis B among blood donors in southern Brazil
Provedor de dados: 55
Autores: Wolff,Fernando Herz; Fuchs,Sandra Costa; Brandão,Ajacio BM.
BACKGROUND: Occult hepatitis B virus (HBV) infection is characterized by the detection of HBV DNA in serum and/or in liver in the absence of detectable hepatitis B surface antigen (HBsAg). The reported prevalence of occult hepatitis B varies markedly among populations and according to the sensitivity of the HBV DNA assay. The aim of the present study was to describe the prevalence of occult hepatitis B among HCV-infected and non-infected blood donors in Porto Alegre, Southern Brazil, using a highly sensitive real time polymerase chain reaction (PCR) method. METHODOLOGY: Between 1995 and 1997 a sample of 178 blood donors with two positive anti-HCV ELISA tests were consecutively selected as cases, and 356 anti-HCV negative donors were selected as controls....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Hepatitis B virus; Blood donors; Seroepidemiologic studies.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200012

Accidents with biological material among undergraduate nursing students in a public Brazilian university
Provedor de dados: 55
Autores: Reis,Renata Karina; Gir,Elucir; Canini,Silvia Rita M. S.
During their academic activities, undergraduate nursing students are exposed to contamination by bloodborne pathogens, as well as by others found in body fluids, among which are the Human Immunodeficiency (HIV), Hepatitis B and C viruses. We developed a profile of victimized students, characterizing accidents with biological material occurring among undergraduate nursing students at a public university in São Paulo State, Brazil. We identified the main causes and evaluated the conduct adopted by students and their reactions and thoughts concerning the accidents. Seventy-two accidents were identified, of which 17% involved potentially contaminated biological material. Needles were the predominant cause of accidents. The most frequently involved topographic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Undergraduate students; Occupational accident; Biosafety.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100003

Accuracy of a self-collection kit for the microbiological study of the vaginal content
Provedor de dados: 55
Autores: Passos,Mauro Romero L.; Varella,Renata Q.; Barreto,Nero A.; Garcia,Maria Luiza; Giraldo,Paulo C.
Diagnosis of vaginal discharge is frequently performed in an empirical way, leading to inadequate treatment. This study tested the accuracy of a self-collection kit for microbiological study of the vaginal content. One hundred and forty-two women of Family Health Program units in Niterói and Piraí cities were enrolled in order to have their vaginal content studied. A brief explanation and a self-collection kit were provided in order to sample the vaginal content. The self-collection kit was composed of one empty plastic tube, two glass slides, a long handle cytobrush, an identification card and guideline notes. The vaginal sample was applied on the glass slides by the women and stained by Gram technique. A second sampling was done by the medical personnel....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Self-collection kit; Vaginitis; Diagnosis; Vaginal discharge; Bacterial vaginosis; Vaginal flora.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200017

Accurate diagnosis and treatment of Vibrio vulnificus infection: a retrospective study of 12 cases
Provedor de dados: 55
Autores: Matsuoka,Yoshinori; Nakayama,Yukishi; Yamada,Tomoko; Nakagawachi,Akira; Matsumoto,Kouichi; Nakamura,Kimihide; Sugiyama,Kyousuke; Tanigawa,Yoshinori; Kakiuchi,Yoshinobu; Sakaguchi,Yoshiro.
BACKGROUND AND AIMS: Vibrio vulnificus causes an infectious disease that has extremely poor convalescence and leads to necrotic fasciitis. In this study, we sought to define the characteristic epidemiology of V. vulnificus infection and clarify its diagnosis at the global level. METHODS: Over a period of 10 years, we investigated the appearance of symptoms, underlying conditions, treatment, and mortality in 12 patients (eight men, four women; &gt;50 years old; average age, 66 years,) infected with V. vulnificus. RESULTS: The development of symptoms occurred primarily between June and September, a period during which seawater temperature rises and the prevalence of V. vulnificus increases. All patients had underlying diseases, and seven patients reported a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vibrio vulnificus; Cellulitis/phlegmon; Necrotic fasciitis; Amputation.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100002

ACKNOWLEDGEMENTS
Provedor de dados: 55
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600652

Acknowledgements
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/report
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800001

Acremonium kiliense infection in a child with chronic granulomatous disease
Provedor de dados: 55
Autores: Pastorino,Antonio Carlos; Menezes,Ulissis Pádua de; Marques,Heloisa Helena de Souza; Vallada,Marcelo G.; Cappellozi,Vera Lúcia; Carnide,Eugénia Maria Grilo; Jacob,Cristina Miuki Abe.
Infection by unusual microorganisms can be one of the clinical manifestations of primary immunodeficiency (PID). We report on a four-month-old child with pneumonia caused by the fungus Acremonium kiliense as the first clinical manifestation of chronic granulomatous disease. We emphasize the importance of an active search for unusual organisms in immunodeficient patients, and a precise diagnosis and early institution of specific treatment against such microorganisms for the reduction of the morbidity and mortality of these patients.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Infancy; Immunodeficiency; Chronic granulomatous disease; Fungi; Acremonium.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600014

Actinomycosis simulating malignant large bowel obstruction
Provedor de dados: 55
Autores: Bittencourt,José Augusto Ferreira; Andreis,Elmes Luiz; Lima,Eduardo Lahude; Dorn,Dalvani Elias; Muller,Virgínia.
We present a case of a 58 year old white male who entered the hospital with abdominal pain and developed large bowel obstruction, simulating malignant disease. Anatomopathological examination showed abdominal actinomycosis, a rare presentation of this disease.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Actinomycosis; Abdominal; Bowel obstruction.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200011

Active pulmonary tuberculosis manifesting with idiopathic thrombocytopenic purpura: a rare presentation
Provedor de dados: 55
Autores: Tabarsi,Payam; Merza,Muayad Aghali; Marjani,Majid.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600017

Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America - results of AWARE surveillance 2012
Provedor de dados: 55
Autores: Hoban,Daryl; Biedenbach,Douglas; Sahm,Daniel; Reiszner,Edina; Iaconis,Joseph.
ABSTRACT As part of the Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) surveillance program in 2012 the in vitro activity of ceftaroline and relevant comparator antimicrobials was evaluated in six Latin American countries (Argentina, Brazil, Chile, Colombia, Mexico and Venezuela) against pathogens isolated from patients with hospital associated skin and soft tissue infections (SSTIs). The study documented that ceftaroline was highly active (MIC90 0.25 mg/L/% susceptible 100%) against methicillin-susceptible Staphylococcus aureus, methicillin-resistant S. aureus (MIC90 2 mg/L/% susceptible 83.3%) and ß-hemolytic streptococci (MIC90 0.008-0.015 mg/L/% susceptible 100%). The activity of ceftaroline against selected species of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftaroline; Skin pathogens; Latin America.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600596

Acute acalculous cholecystitis in a teenager with hepatitis a virus infection: a case report
Provedor de dados: 55
Autores: Souza,Luiz José de; Braga,Lílian Costa; Rocha,Natally de Souza Maciel; Tavares,Rachel Ribeiro.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100017

Acute atrial fibrillation during dengue hemorrhagic fever
Provedor de dados: 55
Autores: Veloso,Henrique Horta; Ferreira Júnior,João Anísio; Paiva,Joyce Morgana Braga de; Honório,Júlio Faria; Bellei,Nancy C. Junqueira; Paola,Angelo Amato Vincenzo de.
Dengue fever is a viral infection transmitted by the mosquito, Aedes aegypti. Cardiac rhythm disorders, such as atrioventricular blocks and ventricular ectopic beats, appear during infection and are attributed to viral myocarditis. However, supraventricular arrhythmias have not been reported. We present a case of acute atrial fibrillation, with a rapid ventricular rate, successfully treated with intravenous amiodarone, in a 62-year-old man with dengue hemorrhagic fever, who had no structural heart disease.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Atrial fibrilation; Dengue; Arrhythmia.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600010

Acute cor pulmonale due to lymphocytic interstitial pneumonia in a child with AIDS
Provedor de dados: 55
Autores: Moreira-Silva,Sandra Fagundes; Moreno,Linda Marly C.; Dazzi,Mariana; Freire,Consuelo Maria Caiafa; Miranda,Angelica Espinosa.
BACKGROUND: Acute cor pulmonale is a clinical syndrome with signs of right-sided heart failure resulting from sudden increase of pulmonary vascular resistance. CASE PRESENTATION: A five-year-old male, infected by human immunodeficiency virus (HIV), was admitted at the division of infectious diseases of this hospital with cough, tachydyspnea, fever, and breathing difficulty. Computed tomography scan showed ground-glass opacities, cystic lesions, and bronchiectasis. The patient had nasal flaring, intercostal and subcostal retractions, and keeled chest. Abdomen was depressible; liver was 3 cm from the right-costal border, while spleen was 6 cm from the left-costal border. Echocardiogram examinations showed signs of acute cor pulmonale characterized by...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acquired immunodeficiency syndrome; Adult; Children; Respiratory tract infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300013

Acute disseminated paracoccidioidomycosis in a 3 year-old child
Provedor de dados: 55
Autores: Grossklaus,Daciene de Arruda; Tadano,Tomoko; Breder,Sandra Assis; Hahn,Rosane Christine.
Clinical cases involving paracoccidioidomycosis in children, diagnosed in Mato Grosso State, in the central western region of Brazil, are rare despite the state being classified with a moderate to high incidence. We describe a clinical case of infant acute disseminated Paracoccidioidomycosis in Mato Grosso State, Brazil, highlighting the importance of early differential diagnosis from other severe pathologies, thus contributing to the survival of compromised patients. A 3 year-old male child, weighing 12.8 Kg, originating from Vila Rica, MT, Brazil. The patient presented intermittent 40ºC fever evolving over 40 days, dry cough and painless bilateral cervical adenomegaly, showing no signs of inflammation. This was associated with diarrhea, distension and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acute paracoccidioidomycosis; Children; Antifungal.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300018

Acute exacerbation of chronic hepatitis B virus infection in renal transplant patients
Provedor de dados: 55
Autores: Emori,Christini Takemi; Perez,Renata Melo; Matos,Carla Adriana Loureiro de; Uehara,Silvia Naomi Oliveira; Pereira,Patricia da Silva Fucuta; Feldner,Ana Cristina Amaral; Carvalho Filho,Roberto José de; Silva,Ivonete Sandra de Souza e; Silva,Antonio Eduardo Benedito; Ferraz,Maria Lucia Gomes.
Introduction:There is scarce information regarding clinical evolution of HBV infection in renal transplant patients.Aims:To evaluate the prevalence of acute exacerbation in HBV-infected renal transplant patients and its association with the time after transplantation, presence of viral replication, clinical evolution, and use of antiviral prophylaxis.Materials and methods:HBV infected renal transplant patients who underwent regular follow-up visits at 6-month intervals were included in the study. The criteria adopted to characterize exacerbation were: ALT &gt;5 × ULN and/or &gt;3 × baseline level. Predictive factors of exacerbation evaluated were age, gender, time on dialysis, type of donor, post-transplant time, ALT, HBeAg, HBV-DNA, HCV-RNA,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Renal transplantation; Hepatitis B; ALT flare; Lamivudine.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600625

Acute hemiplegia associated with cat-scratch disease
Provedor de dados: 55
Autores: Rocha,J.L.; Pellegrino,L.N.; Riella,L.V.; Martins,L.T.
Cat scratch disease (CSD) is an infectious illness caused by a Gram-negative rod named Bartonella henselae. Typical CSD is characterized by a small skin lesion at the site of a scratch or a bite, followed by regional lymphadenopathy, one to two weeks later. Atypical forms may present as ocular manifestations, neurological manifestations, hepatosplenic involvement and vertebral osteomyelitis. Among neurological complications, encephalopathy is by far the most common. Other neurological manifestations are very rare. We report a case of an 11-year-old boy, with a posterior cervical lymphadenopathy and fever. Cat scratch disease was diagnosed and treated after a positive "Whartin-Starry" stain on lymph node biopsy. Two weeks after treatment, the patient was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cat-scratch disease; Acute hemiplegia; Corticosteroid treatment.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300012

Acute hepatitis due to dengue virus in a chronic hepatitis patient
Provedor de dados: 55
Autores: Souza,L.J; Coelho,J.M.C.O.; Silva,E.J.; Abukater,M.; Almeida,F.C.R.; Fonte,A. S.; Souza,L.A.
We present a case of acute hepatitis caused by dengue virus, with a significant increase in aspartate transferase and alanine transferase levels in a chronic hepatitis patient attended at the Cane Sugar Planters Hospital of Campos dos Goytacazes, RJ.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Liver failure; Chronic hepatitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500021

Acute HIV infection with rapid progression to AIDS
Provedor de dados: 55
Autores: Silva,Marcio de Oliveira; Bastos,Milena; Martins Netto,Eduardo; Gouvea,Nancy Alves de Lima; Torres,Alex Jose Leite; Kallas,Esper; Watkins,David I; Altfeld,Marcus; Brites,Carlos.
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Acute infection; Progression; AIDS.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016

Acute liver failure complicating viral hepatitis A
Provedor de dados: 55
Autores: Diniz-Santos,Daniel Rui; Melo,Maria Clotildes Nunes de; Melo,Rita Franca; Silva,Luciana Rodrigues.
Hepatitis A is one of the most frequent infectious liver diseases affecting children worldwide. The disease is usually mild and self-limited, and complications are very rare. Nevertheless, hepatitis A can sometimes cause acute liver failure (ALF), a severe, life-threatening condition. Herein is reported a case of a child who presented ALF during a course of hepatitis A. The need for early identification of possible ALF cases among hepatitis A patients, and for effective ways of evaluating such a possibility, are discussed. We also emphasize the importance of prevention measures, especially vaccination.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hepatitis A; Acute liver failure; Children.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200009

Acute pancreatitis associated with boceprevir: a case report
Provedor de dados: 55
Autores: Bilar,Juliana Miguel; Carvalho-Filho,Roberto José; Mota,Carolina Frade Magalhães Girardin Pimentel; Fucuta,Patricia da Silva; Ferraz,Maria Lucia Cardoso Gomes.
Approximately 170 million people are infected with hepatitis C, and the sustained virological response rate to treatment with pegylated interferon and ribavirin is 30-50%. In an attempt to improve the chances of cure, boceprevir is being added to therapy, but it is associated with an increased incidence of adverse events. We herein report a case of acute pancreatitis developed during treatment with pegylated interferon, ribavirin and boceprevir. Boceprevir was the most likely cause of drug-associated pancreatitis after the most common causes were ruled out, since this adverse event had not occurred when the patient had previously been exposed to pegylated interferon and ribavirin and there was no recurrence of the episode of pancreatitis when these two...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hepatitis C; Protease inhibitor; Side effect.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400454

Acute pancreatitis associated with lamivudine therapy for chronic B hepatitis
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Guastini,Cristina Maria de Fátima; Boulos,Maria Ivete Castro.
Hyperamylasemia is a common complication during lamivudine use. We report a case of a pancreatitis following lamivudine therapy. A careful monitoring of amylase levels during treatment with lamivudine is discussed, mainly in the first weeks, considering the cost of this exam and further complication.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lamivudine; Pancreatitis; Amylases; Hyperamilasemina; Hepatitis; Chronic B hepatitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400001

Acute respiratory distress syndrome due to vivax malaria: case report and literature review
Provedor de dados: 55
Autores: Lomar,André V.; Vidal,José E.; Lomar,Frederico P.; Barbas,Carmen Valente; Matos,Gustavo Janot de; Boulos,Marcos.
Severe pulmonary involvement in malaria has been frequently reported in cases of Plasmodium falciparum infection, but rarely in vivax malaria. Among the 11 previous cases of vivax-related severe respiratory involvement described in the literature, all except one developed it after the beginning of anti-malarial treatment; these appear to correspond to an exacerbation of the inflammatory response. We report the case of a 43-year-old Brazilian woman living in a malaria-endemic area, who presented acute respiratory distress syndrome (ARDS) caused by P. vivax before starting anti-malarial treatment. The diagnosis was made based on microscopic methods. A negative rapid immunochromatographic assay, based on the detection of Histidine Rich Protein-2 (HRP-2) of P....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium vivax; Acute respiratory distress syndrome; Acute respiratory failure; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500011

Adherence to acute otitis media treatment guidelines among primary health care providers in Israel
Provedor de dados: 55
Autores: Shviro-Roseman,Noa; Reuveni,Haim; Gazala,Eli; Leibovitz,Eugene.
AIMS: To determine the appropriateness of the acute otitis media antibiotic treatment prescribed in the community in relation to the therapeutic guidelines. METHODS: Children aged 3 months-3 years diagnosed with simple uncomplicated acute otitis media in 6 community primary care clinics were enrolled. Data on the antibiotic treatment were collected using computerized medical files. RESULTS: 689 simple uncomplicated acute otitis media patients were enrolled; 597 (86.9%) were treated with antibiotics by 38 family medicine practitioners, 12 pediatricians and 7 general practitioners. 461 (77.2%) patients were &lt;2 years of age. Amoxicillin was administered to 540 (90.5%) patients, with no differences between the various medical specialties. 127/540 (23.5%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute otitis media; Antibiotics; Physicians; Communit.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400355

Adherence to an occupational blood borne pathogens exposure management program among healthcare workers and other groups at risk in Argentina
Provedor de dados: 55
Autores: Miceli,Marisa; Herrera,Fabián; Temporiti,Elena; Li,Dong; Vila,Andrea; Bonvehí,Pablo.
We conducted a retrospective review of 130 occupational blood borne pathogens exposure (BBP-OE) records at Centro de Estudios Médicos e Investigaciones Clínicas, a university hospital with an ongoing educational program and a postexposure management program for healthcare workers (HCWs) since 1995, in order to evaluate adherence to a hospital BBP-OE management program. We compared HCWs from our institution (Group 1) and HCWs from independent institutions that contract our postexposure management program (Group 2). Compliance with standard precautions in Group 1 was inadequate in 77%, 23%, and 16% of nurses, physicians, and others, respectively. A greater proportion of HCWs in Group 1 (74% vs. 40%) reported occupational accidents within two hours after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Healthcare workers; Postexposure prophylaxis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600002

Adherence to antiretroviral prophylaxis during early infancy in Latin America
Provedor de dados: 55
Autores: Hofer,Cristina B.; Harris,D. Robert; Saavedra,Mariza C.; Haberer,Jessica E.; Romeiro,Juliana; Mussi-Pinhata,Marisa M.; Stankievich,Erica; Gomes,Ivete M.; Kreitchmann,Regis; Read,Jennifer S.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400019

Adherence to antiretroviral therapy of Brazilian HIV-infected children and their caregivers
Provedor de dados: 55
Autores: Ricci,Gabriela; Netto,Eduardo Martins; Luz,Estela; Rodamilans,Cynthia; Brites,Carlos.
Abstract  Background Successful treatment of HIV-positive children requires a high level of adherence (at least 95%) to highly active antiretroviral therapy. Adherence is influenced by factors related to the child and caregivers.  Objectives To evaluate children and caregivers characteristics associated to children's adherence.  Methods Cross-sectional study, from September 2013 to June 2015, comprising a sample of caregivers of perinatally HIV-infected children, in the age group of 1–12 years, under antiretroviral therapy for at least 6 months and on follow-up in two AIDS reference centers in Salvador, Bahia. Caregiver self-reports were the sole source of 4 days adherence and sociodemographic information. Study participants who reported an intake &gt;95%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adherence; Antiretroviral therapy; Children; Caregivers.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500429

Adherence to guidelines for surgical antibiotic prophylaxis: a review
Provedor de dados: 55
Autores: Gouvêa,Marise; Novaes,Cristiane de Oliveira; Pereira,Daniele Masterson Tavares; Iglesias,Antonio Carlos.
ABSTRACTCONTEXT AND OBJECTIVES: The appropriate use of antibiotic prophylaxis in the perioperative period may reduce the rate of infection in the surgical site. The purpose of this review was to evaluate adherence to guidelines for surgical antibiotic prophylaxis.METHODS:The present systematic review was performed according to the Cochrane Collaboration methodology. The databases selected for this review were: Medline (via PubMed), Scopus and Portal (BVS) with selection of articles published in the 2004-2014 period from the Lilacs and Cochrane databases.RESULTS:The search recovered 859 articles at the databases, with a total of 18 studies selected for synthesis. The outcomes of interest analyzed in the articles were as follows: appropriate indication of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotic prophylaxis; Antimicrobial prophylaxis; Guideline adherence; Surgical patient.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500517

Admission of foreign citizens to the general teaching hospital of bologna, northeastern Italy: An epidemiological and clinical survey
Provedor de dados: 55
Autores: Sabbatani,Sergio; Baldi,Elena; Manfredi,Roberto; Chiodo,Francesco.
BACKGROUND: The emergency regarding recent immigration waves into Italy makes continued healthcare monitoring of these populations necessary. METHODS: Through a survey of hospital admissions carried out during the last five years at the S. Orsola-Malpighi General Hospital of Bologna (Italy), all causes of admission of these subjects were evaluated, together with their correlates. Subsequently, we focused on admissions due to infectious diseases. All available data regarding foreign citizens admitted as inpatients or in Day-Hospital settings of our teaching hospital from January 1, 1999, to March 31, 2004, were assessed. Diagnosis-related group (DRG) features, and single discharge diagnoses, were also evaluated, and a further assessment of infectious...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Foreign citizens; Hospitalization; Immigration; Demographic and epidemiological features; Clinical diagnoses; Infectious diseases; Outcome.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200001

Adolescents growing with HIV/AIDS: experiences of the transition from pediatrics to adult care
Provedor de dados: 55
Autores: Machado,Daisy Maria; Galano,Eliana; de Menezes Succi,Regina Célia; Vieira,Carla Maria; Turato,Egberto Ribeiro.
Abstract The main objective of this work is to describe the formation of the Transition Adolescent Clinic (TAC) and understand the process of transitioning adolescents with HIV/AIDS from pediatric to adult care, from the vantage point of individuals subjected to this process. A qualitative method and an intentional sample selected by criteria were adopted for this investigation, which was conducted in São Paulo, Brazil. An in-depth semi-structured interview was conducted with sixteen HIV-infected adolescents who had been part of a transitioning protocol. Adolescents expressed the need for more time to become adapted in the transition process. Having grown up under the care of a team of health care providers made many participants have reluctance toward...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Health care transition; Adolescent.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300002

Adult Reye-like syndrome associated with serologic evidence of acute parvovirus B19 infection
Provedor de dados: 55
Autores: Costa,Paulo Sérgio Gonçalves da; Ribeiro,Geyza Machado; Vale,Thiago Cardoso; Casali,Thaís Gomes; Leite,Flávio José Barbosa.
Reye's syndrome is an infrequently diagnosed medical condition affecting mainly children. The etiology, epidemiology and natural history of Reye's syndrome have been cloudily written in footnotes of medical books and exotic papers since the initial description in early 1950s. We report here a case of adult Reye's syndrome associated with serologic evidence of parvovirus B19 infection.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Reye's syndrome; Parvovirus B19; Human adult.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500012

Adult T-cell leukemia/lymphoma (ATL) in Bahia, Brazil
Provedor de dados: 55
Autores: Bittencourt,Achiléa L.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500020

Adverse event management
Provedor de dados: 55
Autores: Vigani,Aline Gonzalez.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700020

Aerobic capacity and health-related quality of life in adults HIV-infected patients with and without lipodystrophy
Provedor de dados: 55
Autores: Gomes Neto,Mansueto; Conceição,Cristiano Sena; Ogalha,Cecília; Brites,Carlos.
Abstract  Introduction HIV infection and its therapy which can affect their aerobic capacity and health-related quality of life of patients.  Objective We conducted a cross-sectional study to determine if aerobic capacity and health related quality of life was decreased in HIV-infected patients receiving highly active antiretroviral therapy and comparing patients with and without lipodystrophy.  Research design and methods HIV-infected patients older than 18 years, and in current use of highly active antiretroviral therapy drugs, were evaluated for blood count, fasting total cholesterol, high density lipoprotein, triglycerides, glucose, HIV viral load and CD4/CD8 counts, body composition, peak oxygen consumption (peak VO2) and metabolic equivalent. Health...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; HIV infection; Quality of life; Disability.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100076

Aeromonas caviae septicemia in immunocompetent gastrointestinal carriers
Provedor de dados: 55
Autores: Dwivedi,M.; Mishra,A.; Prasad,A.; Azim,A.; Singh,R.K.; Baronia,A.K.; Prasad,K.N.; Dwivedi,U.N.
Aeromonas caviae strains have been isolated from blood and stool cultures of three immunocompetent patients, residents of Northern India, who presented with community acquired septicemia without any recent history of diarrhea. Cell culture infectivity test performed on Hep-2 cells have shown substantial degree of invasiveness in the isolated strains. This case unleashes a possibility of asymptomatic gastrointestinal carriage of such strains of A. caviae in a very large population of India, as several areas of India have very high rates of Aeromonas induced acute diarrhea/gastroenteritis (up to 13%). It needs to be appraised further in India as well as other countries having high rates of Aeromonas induced acute diarrhea/gastroenteritis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aeromonas caviae; Septicemia; Gastrointestinal carriage.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600023

Aeromycological study at the intensive care unit of the "Dr. Manuel Gea Gonzalez" General Hospital
Provedor de dados: 55
Autores: Ríos-Yuil,José Manuel; Arenas,Roberto; Fernández,Ramón; Calderón-Ezquerro,María; Rodriguez-Badillo,Raymundo.
INTRODUCTION: An aeromycological study verifies the presence and quantifies the concentration of fungal propagules in the air. It is very important in the hospital setting because of the increasing numbers of immunosuppressed and severely ill patients. The objective of this study was to determine the concentration of fungi in the air of the intensive care unit (ICU) of "Dr. Manuel Gea González" General Hospital. METHODS: This is a descriptive, observational cross-sectional study. Air samples were obtained with a single stage Thermo-Andersen Viable Particle Sampler (Thermo Electron Corporation -Massachusetts, U.S.A.) in a Petri dish with potato dextrose agar for 15 minutes at two different times (morning and afternoon) and heights (1 and 1.5 meters). The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fungi; Air; Sampling; Colony-forming units.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500005

Aggressive Non-Hodgkin's Lymphoma: therapeutic considerations of pre rituximab era
Provedor de dados: 55
Autores: Souza,Carmino Antônio de.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500022

Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals
Provedor de dados: 55
Autores: Pinheiro,Cezar Arthur Tavares; Souza,Luciano Dias de Mattos; Motta,Janaína Vieira dos Santos; Kelbert,Evelin Franco; Martins,Clarissa de Souza Ribeiro; Souza,Marília Silva de; Pinheiro,Karen Amaral Tavares; Coelho,Fábio Monteiro da Cunha; Pinheiro,Ricardo Tavares.
ABSTRACT  Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients.  Materials and methods: We conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; HIV; Neurocognitive impairment; Adherence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600599

Aging with HIV: a practical review
Provedor de dados: 55
Autores: Cardoso,Sandra Wagner; Torres,Thiago Silva; Santini-Oliveira,Marilia; Marins,Luana Monteiro Spindola; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz.
The worldwide elderly population is expected to grow by an additional 694 million people by 2025. By that time, there will be approximately two billion elderly people in the world, most of whom (80%) will be living in developing countries. Based on recent estimates, this population will number over 40 million in 2030 in Brazil and a consequent increase in governmental spending for this population can be expected. Since highly active antiretroviral therapy became available in the mid-1990s, the life expectancy of people living with HIV has increased significantly. Approximately 12 million life years were added to the world between 1996 and 2008 as a consequence of wider access to highly active antiretroviral therapy. In Brazil, the incidence of AIDS among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400013

Aging with HIV: an overview of an urban cohort in Rio de Janeiro (Brazil) across decades of life
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane de Souza; Marins,Luana Monteiro Spindola; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.
The introduction of highly active antiretroviral therapy during the 1990s was crucial to the decline in the rates of morbidity and death related to the acquired immunodeficiency syndrome (AIDS) and turned human immunodeficiency virus (HIV) infection into a chronic condition. Consequently, the HIV/AIDS population is becoming older. The aim of this study was to describe the immunological, clinical and comorbidity profile of an urban cohort of patients with HIV/AIDS followed up at Instituto de Pesquisa Clinica Evandro Chagas, Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Retrospective data from 2307 patients during January 1st, 2008 and December 31st, 2008 were collected. For continuous variables, Cuzick's non-parametric test was used. For categorical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300004

Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report
Provedor de dados: 55
Autores: Silva,Itathiana MªC.B. da; Oliveira,Caroline A.P. de; Guedes,Wilma R.C. de A.; Oliveira,Benedito Bruno de; Oliveira,Doris Amorim Pontes de; Guedes Filho,Gilson.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200018

AIDS and disseminated tuberculosis after Immune Reconstitution Inflammatory Syndrome
Provedor de dados: 55
Autores: Sengoz,Gonul; Sengoz,Ahmet; Pehlivanoglu,Filiz.
Tipo: Info:eu-repo/semantics/article
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400462

AIDS-associated diarrhea and wasting in northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum
Provedor de dados: 55
Autores: Brantley,Richard K.; Williams,K. Robert; Silva,Terezinha M.J.; Sistrom,Maria; Thielman,Nathan M.; Ward,Honorine; Lima,Aldo A. M.; Guerrant,Richard L.
Advanced HIV infection is frequently complicated by diarrhea, disruption of bowel structure and function, and malnutrition. Resulting malabsorption of or pharmacokinetic changes in antiretroviral agents might lead to subtherapeutic drug dosing and treatment failure in individual patients, and could require dose adjustment and/or dietary supplements during periods of diarrheal illness. We determined the plasma levels of antiretroviral medications in patients that had already been started on medication by their physicians in an urban infectious diseases hospital in northeast Brazil. We also obtained blood samples from patients hospitalized for diarrhea or AIDS-associated wasting, and we found reduced stavudine and didanosine levels in comparison with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Malabsorption; DdI; D4T; Pharmacokinetics.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100003

AIDS-related cerebral toxoplasmosis in São Paulo State, Brazil: marked improvements in the highly active antiretroviral therapy-era but the challenges continue
Provedor de dados: 55
Autores: Vidal,Jose E.; Oliveira,Augusto C. Penalva de.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300013

AIDS-related lymphomas in Nigeria
Provedor de dados: 55
Autores: Bolarinwa,R.A.; Ndakotsu,M.A.; Oyekunle,A.A.; Salawu,L.; Akinola,N.O.; Durosinmi,M.A.
Aggressive non-Hodgkin's lymphoma (NHL), including primary central nervous system (CNS) lymphoma, lymphoblastic lymphoma and non-endemic Burkitt's lymphoma have been recognized as AIDS-defining cancers in most developed countries. However, HIV/AIDS epidemics appear not to have been associated with higher incidence of lymphomas in Africa. We therefore carried out this study to highlight the significance or otherwise of HIV/AIDS epidemics in the pathogenesis of lymphomas in a population of Nigerians with the disease. Since January 1993 to the present, all patients with haematologic cancers are routinely screened (following appropriate counseling) for HIV infection. Patients with a histological diagnosis of malignant chronic lymphoproliferative diseases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Lymphoma; Nigerians.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500009

Alcohol consumption and associated factors among HIV/AIDS patients
Provedor de dados: 55
Autores: de Oliveira,Luiz Carlos Marques; dos Anjos,Marcelo Guerra Tannús; Macedo Mustafé,Rafael; Sebastião Borges,Aércio.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300022

Alteration in the erythrocyte sedimentation rate in dengue patients: analysis of 1,398 cases
Provedor de dados: 55
Autores: Souza,Luiz José de; Reis,Aldo Franklin Ferreira; Almeida,Fernanda Carlos Rodrigues de; Souza,Lara Assed de; Abukater,Marina; Gomes,Maurício Assed Estefan; Abicair,Olívia Araujo; Gonçalves,Pedro Assed.
A study of the erythrocyte sedimentation rate during the first hour (ESR) in dengue patients would help determine how this parameter is affected by this disease, as well as whether it can be used for diagnosis. One thousand, three hundred and ninety-eight cases of dengue attended at the Dengue Treatment Center, Campos dos Goytacazes Rio de Janeiro, Brazil, were included. The ESR values were classified as normal or elevated and compared by gender and clinical form of the disease. Among the 1,398 cases ESR was normal in 81.25% (n = 1,136), while in 18.75% (n=262) it was elevated. In 83.92% (n=514) of the male dengue patients ESR was normal, while in 16.08% (n=98) it was elevated. Among female dengue patients, 79.17% (n=622) had normal ESR, and in 20.83%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue fever; Erythrocyte sedimentation rate (ESR); Diagnosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600005

Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases
Provedor de dados: 55
Autores: Souza,Luiz José de; Alves,José Galvão; Nogueira,Rita Maria Ribeiro; Gicovate Neto,Carlos; Bastos,Diogo Assed; Siqueira,Edno Wallace da Silva; Souto Filho,João Tadeu Damian; Cezário,Thiago de Abreu; Soares,Carlos Eduardo; Carneiro,Rodrigo da Costa.
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis. MATERIAL AND METHODS: An analysis was made of 1,585 serologically confirmed dengue cases at the Dengue Reference Center in Campos dos Goytacazes, Rio de Janeiro state. The grade of hepatic aggression was established according to the alterations in the aminotransferase levels: grade A - normal levels of aminotransferase; grade B - elevated aminotransferase, with increased levels of at least one of the enzymes; grade C - elevated aminotransferase, with the levels of at least one of the enzymes increased to more than three times the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue fever; Aminotransferase; Hepatic injury.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200006

Amoebic renal cyst: a case report
Provedor de dados: 55
Autores: Sharma,Anuradha; Chandel,U.K.; Gupta,M.L.; Sharma,Vijay; Sharma,R.K.
Entamoeba histolytica can infect any organ of the body, but only one case of renal involvement has been reported till now in the literature. We report a rare case of amoebic renal cyst in a 78-yearshowing favorable outcome with metronidazole treatment and therapeutic drainage.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Renal; Amoebic; Cyst.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300011

Amphotericin B-related nephrotoxicity in low-risk patients
Provedor de dados: 55
Autores: Berdichevski,Roberto Herz; Luis,Luciano Billodre; Crestana,Letícia; Manfro,Roberto Ceratti.
INTRODUCTION: Amphotericin B (AmphoB) is the drug of choice for treatment of severe fungal illnesses; however, it is very nephrotoxic. Modified (less toxic) amphotericins are very expensive. In low-risk patients, saline loading would be enough to prevent significant loss of renal function. MATERIAL AND METHODS: Patients with normal renal function and within the first 24 hours of treatment with AmphoB were prospectively enrolled in the study. Patients in intensive care units or who were using vasoactive drugs were excluded. Saline loads were infused before and after the AmphoB treatment. Blood and urine analyses were made at the beginning and at the end of the treatment. Serum creatinine was repeated 30 days after the end of the AmphoB treatment. RESULTS:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphotericin B; Acute renal failure; Nephrotoxicity; Sodium chloride.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200005

An adherence trilogy is essential for long-term HAART success
Provedor de dados: 55
Autores: Garcia,Rosa; Schooley,Robert T.; Badaró,Roberto.
Adherence is the milestone of a successful therapy. Over the last decade several authors have addressed the importance of adherence for optimal results of antiretroviral (ARV) therapy. Many health care systems are investing substantial resources to make available contemporary antiretroviral therapy. Despite the large investment in medications, insufficient investments have been made into an integrated adherence component to maximize the impact of these medications. Adherence, unlike drug therapy, cannot be defined as a single method with a defined prescription or formula. Instead, it is the result of a complex interaction between the patient, a prescribed medication and the health system. Many reports are available analyzing each of these components. We...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adherence; Compliance; Antiretroviral therapy.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500005

An epidemiological study of Haemophilus influenzae at a Brazilian day care center
Provedor de dados: 55
Autores: Bonifácio da Silva,M.E.; Marin,J.M.
Day care centers are a relatively new phenomenon in Brazil that bring together large numbers of young children susceptible to contagious diseases. Haemophilus influenzae (Hi) is an important infection in the age range of those attending day care centers. In the present study, the carriage rate of Haemophilus influenzae was identified in 38 day care attendees age 6 to 37 months, and 23 staff members, at a day care center in Ribeirão Preto-São Paulo, in 1997. To identify the carriers, two nasopharyngeal swabs were collected; one in July and one in December. The rate of H. influenzae carriers among the children was 77%. Only 2 of 23 staff members (9%) had Hi. Among the children, there were 58 isolates in the two sampling periods; 6 of the Hi were serotype b,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haemophilus influenzae; Day care; Colonization.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500004

An exuberant form of disseminated histoplasmosis
Provedor de dados: 55
Autores: Rockenbach,Débora Mânica; Dallazem,Lia Natalia Diehl; Chemello,Raíssa Londero; Beber,André Avelino Costa.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300243

An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil
Provedor de dados: 55
Autores: Basano,S.A.; Bianco,A.; Taylor,W.R..J; Olliaro,P.; Camargo,L.M.A.
Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Mefloquine; Amazon; Rondônia; Therapeutics.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013

An open label, multicenter, non-comparative study of the efficacy and safety of oral gatifloxacin in the treatment of community-acquired pneumonia: a Brazilian study in five centers
Provedor de dados: 55
Autores: Nicodemo,Antonio Carlos.
We made an open label, multicenter, non-comparative study to assess the efficacy and safety of oral gatifloxacin, 400mg PO given once-daily during 7 to 14 days for the treatment of adult outpatients with community-acquired pneumonia at five Brazilian medical facilities. Among the 86 subjects available for clinical evaluation, 84 (98%) were cured. The bacteriological eradication and presumed eradication rate was 98% (52/53) among the 44 (51%) patients who were bacteriologically evaluated. Drug-related adverse events were reported by 27% of the patients, diarrhea being the most frequent, occurring in 12% of patients. Adverse events were considered mild (89%) or moderate (11%). We conclude that a 7-14 day course of gatifloxacin, 400mg PO given once daily is...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gatifloxacin; Community-acquired pneumonia; Brazil.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100007

An open multicenter study of the use of gatifloxacin for the treatment of non-complicated acute bacterial rhinosinusitis in adults
Provedor de dados: 55
Autores: Weckx,L.L.M.; Campos,C.A.H.; Sakano,E.; Pignatari,S.S.N.; Figueiredo,C.R.
The bacteriological and clinical efficacy and the safety of gatifloxacin for the treatment of non-complicated acute rhinosinusitis was evaluated in 49 adult patients in an open-label multicenter study in Brazil. Patients under age 18, or with associated systemic diseases, were excluded. Diagnosis was based on symptoms, otorhinolaryngological examination, and X-rays of the sinus. At the first visit, all patients were treated with a single daily dose of 400 mg gatifloxacin for 10 days. Middle nasal meatus secretion was collected and sent for culture before and after treatment. Patients were all reevaluated at days 3 to 5; days + 1 to + 5 and 18 to 25 days + 7 to + 14 . Ninety three percent of the patients were considered clinically cured at the end of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rhinossinusitis; Adults; Gatifloxacin.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200007

An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil
Provedor de dados: 55
Autores: Brito,Denise von Dolinger de; Oliveira,Elias José; Abdallah,Vânia O. Steffen; Darini,Ana Lúcia da Costa; Gontijo Filho,Paulo P.
We studied an outbreak of two multi-drug resistant clones of Acinetobacter baumannii in the Neonatal Intensive Care Unit of the Uberlândia Federal University Hospital in Minas Gerais state, Brazil, and we analyzed the contribution of cross-transmission in the rise in infection rates. Eleven neonates who developed multi-drug resistant A. baumannii nosocomial infection were matched to 22 neonates who were admitted to the same unit and did not develop an infection during the outbreak period, in order to identify risk factors for infection. Three out of the 11 neonates died. Epidemiological investigation included molecular typing, using pulsed field gel electrophoresis. Prior to the outbreak, from December 2001 to March 2002, no case of infection by this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Molecular epidemiology; Outbreak; Neonates.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400006

An outbreak of Candida spp. bloodstream infection in a tertiary care center in Bogotá, Colombia
Provedor de dados: 55
Autores: DiazGranados,Carlos A.; Martinez,Adriana; Deaza,Ceneth; Valderrama,Sandra.
Several cases of Candida bloodstream infections were documented from June to October 2004 at a tertiary care center in Bogotá, Colombia. Since no cases of candidemia had occurred during the preceding four months, an outbreak was declared. As a result, a microbiological study, a revision of infection control practices and a case-control study were performed. In all, 18 cases of candidemia were ascertained. Parenteral nutrition (p=0.04), presence of a central line (p=0.03), and severity of illness (p=0.03) were associated with candidemia in bivariate analysis. Diverse Candida species were observed. Candida parapsilosis contamination was found in plastic containers used for transient intravenous (IV) medication storage at the bedside, plastic bags reused for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Fungemia; Disease outbreaks; Developing countries; Colombia; Latin America.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500009

An outbreak of conjunctivitis caused by multiresistant Pseudomonas aeruginosa in a Brazilian Newborn Intensive Care Unit
Provedor de dados: 55
Autores: Brito,D. V. D.; Oliveira,E. J.; Matos,C.; Abdallah,V. O.S.; Gontijo Filho,P.P.
We report an outbreak of conjunctivitis due to Pseudomonas aeruginosa involving seven infants admitted in the Neonatal Intensive Care Unit (NICU) of the Uberlândial Federal University Hospital between March and September 2001. Three infants developed systemic complications (01 sepsis and 02 pneumonias). Ten isolates were obtained from conjunctival cultures and all were resistant to ceftazidime and aminoglycosides. Fast identification of the organism and treatment with imipenem were important in containing the outbreak of P. aeruginosa.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Pseudomonas aeruginosa; Nosocomial infection; Neonatal unit.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400001

An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in Iran
Provedor de dados: 55
Autores: Farahmand,Mahin; Nahrevanian,Hossein; Shirazi,Hasti Atashi; Naeimi,Sabah; Farzanehnejad,Zahra.
Cutaneous leishmaniasis (CL) is a widespread tropical infection which has a high incidence rate in Iran. Leishmania tropica, the causative agent of anthroponotic cutaneous leishmaniasis (ACL), and Leishmania major, which causes zoonotic cutaneous leishmaniasis (ZCL), are endemic in various parts of Iran with a high incidence rate. The aim of this study was to evaluate the reappraisal of the diagnosis and epidemiology of CL in Iran, by different clinical, parasitological and molecular assays among patients suspected of CL referred to the Department of Parasitology, at the Pasteur Institute of Iran during 2006-2009. Two hundred samples from patients with ulcerative skin lesions were collected, clinical analyses were applied, data questionnaire was completed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parasitological analysis; Molecular biology; Leishmaniasis; Cutaneous; Iran; Epidemiology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100004

An unusual case of ectopic tungiasis with pseudoepitheliomatous hyperplasia
Provedor de dados: 55
Autores: Heukelbach,J.; Sahebali,S.; Van Marck,E.; Sabóia Moura,R.C.; Feldmeier,H.
Tungiasis is caused by the penetration of the female sand flea Tunga penetrans into the epidermis, and subsequent hypertrophy of the parasite. In most cases lesions are confined to the feet. During a cross-sectional study, an unusual case of ectopic tungiasis in the inguinal area was detected. Histological examination of tissue samples showed a remarkable pseudoepitheliomatous aspect of the epidermis. Clinical features and differential diagnoses are discussed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Ectoparasite; Tunga penetrans; Tungiasis; Ectopic localization; Histopathology; Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600012

An unusual cause of bilateral scrotal abscess in a preterm infant: Candida albicans
Provedor de dados: 55
Autores: Cetinkaya,Merih; Buyukkale,Gokhan; Payasli,Muge; Ozbek,Sibel; Kavuncuoglu,Sultan.
Acute scrotal abscess is a rare condition in neonates. Most of these abscesses were reported to be unilateral and caused by Staphylococcus and Salmonella spp. Herein, we report a bilateral scrotal abscess in a preterm infant and Candida albicans was isolated from the scrotal fluid culture. To our knowledge, this is the first bilateral scrotal abscess in a preterm infant caused by C. albicans. Therefore, this organism must be suspected in differential diagnosis of acute scrotal abscess in neonates, especially in preterm infants.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Scrotal abscess; Neonate; Preterm infant; Candida albicans.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200023

An unusual imported case of diphyllobothriosis in Mexico
Provedor de dados: 55
Autores: Rodríguez-Pérez,Elba G.; Escandón-Vargas,Kevin; Castellanos,Jenniffer A.
Tipo: Info:eu-repo/semantics/report
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300355

An unusual presentation of brucellosis: acute hepatitis
Provedor de dados: 55
Autores: Uluğ,Mehmet; Celen,Mustafa Kemal; Ayaz,Celal.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600018

Analysis of drug resistance mutations in pulmonary Mycobacterium tuberculosis isolates in the Southern coastal region of Andhra Pradesh, India
Provedor de dados: 55
Autores: Prasad,Polu Giri; Jasmine,Mohammad Shaik; kanta,Kota Neela Mani; Deepthi,Karumanchi; Allam,Uday Sankar.
ABSTRACT  Purpose and objectives Detection of drug resistance plays a crucial role in tuberculosis (TB) treatment and prevention of Mycobacterium tuberculosis (MTB) transmission. The aim of this study was to determine the levels and patterns of resistance of MTB isolates to two key anti-TB drugs (rifampicin, RIF and isoniazid, INH) and the type of mutations in drug resistance genes (rpoB, katG and inhA) of the isolates at the southern coastal region of Andhra Pradesh, India, using commercially available GenoType MTBDRplus assay under the Revised National TB Control Program.  Methods GenoType MTBDRplus assay was performed on 2859 sputum smear-positive samples and the mutations in the genes responsible for resistance (rpoB, katG and inhA) were analyzed....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multidrug resistance; Mycobacterium tuberculosis; MTBDRplus assay; Mutations; Molecular detection.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500281

Analysis of the use of imipenem at a University Hospital following the restructuring of an antimicrobial audit system
Provedor de dados: 55
Autores: Souza,N.P.; Noblat,A.C.B.; Noblat,L.
This study analyzed the use pattern of imipenem following the restructuring of the antimicrobial audit system at a University Hospital. It was an observational study before and after the restructuring of the antimicrobial audit system in a University Hospital from May to August and then from September to December 2006. The criteria of the rational use of imipenem were obtained from a non-systematic revision of the literature. The collection of data on the general characteristics and clinical state of the patient, the infection and the established therapy was carried out in a previously tested instrument. Data was recorded, revised and analyzed in a database built with the software SPSS® for Windows® PC, version 10.0. The statistical analysis had a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Imipenem; Drug use review; Drug use evaluation; Audit system; Antimicrobial policy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600010

Analytical validation of anti-toxoplasma IgG immunoassays
Provedor de dados: 55
Autores: Souza,Guenael Freire de; Carvalho,Darlene; Pedrosa,William; Franck,Jacqueline; Piarroux,Renaud.
There are often discrepancies when using different methods to measure anti-Toxoplasma gondii IgG levels in patient samples. The diagnostic performance of a chemiluminescent immunoassay (CLIA) and an enzyme-linked fluorescent assay (ELFA) used as confirmatory tests for samples identified as positive or equivocal by an electrochemiluminescent immunoassay (ECLIA) were examined. Cut-off values were those stated by the manufacturer, and Western blot was used to confirm the results of all methods. All samples identified as positive by ECLIA (n = 93) were confirmed as positive by Western blot, as were 14 of the 28 samples identified as equivocal. When these 121 samples were retested, the sensitivities of CLIA and ELFA were 64.4% and 73.8%, respectively. Both...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Toxoplasma; Immunoassay; ECLIA; ELFA.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600012

Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii
Provedor de dados: 55
Autores: Silva,Marcos Gontijo da; Lino Junior,Ruy de Souza; Costa,Tatiane Luiza da; Soares,Joanna D´arc Herzog; Amaral,Waldemar Naves do; Avelino,Mariza Martins; Castro,Ana Maria de.
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Experimental histopathology; Mice brains.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100012

Ancylostoma duodenale as a cause of upper gastrointestinal bleeding: a case report
Provedor de dados: 55
Autores: Ronquillo,Andrea Carlin; Puelles,Lidia Benites; Espinoza,Luis Pampa; Sánchez,Víctor Aguilar; Luis Pinto Valdivia,José.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600471

Aneurysm and dissection in a patient with syphilitic aortitis
Provedor de dados: 55
Autores: Pivatto Júnior,Fernando; Finkler,Bruno Schaaf; Torres,Felipe Soares; Schaefer,Pedro Guilherme; Sprinz,Eduardo.
ABSTRACT In the antibiotic era, aortic aneurysm is a rare complication of syphilis, what makes the diagnostic assumption even more difficult. Nonetheless, this condition should be suspected in patients with aortic aneurysm. Reports of aortic dissection complicating syphilitic aortitis have been distinctly rare in the literature, and their cause-effect relationship has not been definitely established. In this case report, we present a 62-year-old woman with aortic aneurysm and dissection associated with an unexpected diagnosis of syphilitic aortitis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Syphilis Syphilis; Cardiovascular Aneurysm Dissection.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300349

Angina pectoris in patients with HIV/AIDS: prevalence and risk factors
Provedor de dados: 55
Autores: Zirpoli,Josefina Cláudia; Lacerda,Heloisa Ramos; Albuquerque,Valéria Maria Gonçalves de; Albuquerque,Maria de Fátima Pessoa Militão de; Miranda Filho,Demócrito de Barros; Monteiro,Verônica Soares; Barros,Isly Lucena de; Arruda Junior,Evanízio Roque de; Montarroyos,Ulisses Ramos; Ximenes,Ricardo Arraes de Alencar.
INTRODUCTION: The incidence of ischemic heart disease is higher in patients with HIV/AIDS. However, the frequency of angina pectoris in these patients is still not known. Literature about this subject is still scarce. OBJECTIVE: To evaluate the prevalence of angina pectoris and risk factors for coronary disease and to examine the association between traditional risk factors and HIV-related risk factors and angina pectoris. METHOD: An epidemiological cross-sectional study, analyzed as case-control study, involving 584 patients with HIV/AIDS. Angina pectoris was identified by Rose questionnaire, classified as definite or possible. Information regarding risk factors was obtained through a questionnaire, biochemical laboratory tests, medical records and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency; Syndrome; Angina pectoris; Coronary disease; Risk factors.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100001

Angioinvasive pulmonary aspergillosis after allogeneic bone marrow transplantation: clinical and high-resolution computed tomography findings in 12 cases
Provedor de dados: 55
Autores: Gasparetto,Emerson L.; Souza,Carolina A.; Tazoniero,Priscilla; Davaus,Taisa; Escuissato,Dante L.; Marchiori,Edson.
The aim of this study was to present the clinical and high-resolution CT scan findings of angioinvasive pulmonary aspergillosis (APA) in 12 patients who underwent allogeneic bone marrow transplantation (BMT). The CT scans were reviewed by three chest radiologists who assessed the pattern and distribution of findings by consent. There were 7 (58%) female and 5 (42%) male patients, with aging between 5 and 50 years (average of 26 years). All patients were submitted to BMT for the treatment of hematological conditions. The diagnosis of APA was defined between 5 and 373 days after BMT, with average of 111 days. Three cases (25%) were diagnosed in the neutropenic phase after the BMT, five (42%) in the early phase and four patients in the late phase post-BMT....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Invasive pulmonary aspergillosis; Bone marrow transplantation; High-resolution computed tomography.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100024

Anogenital infection by Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected men and women in Salvador, Brazil
Provedor de dados: 55
Autores: Travassos,Ana Gabriela; Xavier-Souza,Eveline; Netto,Eduardo; Dantas,Eda Vinhaes; Timbó,Maiara; Nóbrega,Isabella; Haguihara,Tatiana; Neumayer,Júlia; Lisboa,Nathalia; Soidan,Maria Angela; Ferreira,Fábio; Brites,Carlos.
ABSTRACT  Background: Infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae are the most common bacterial sexually transmitted infections throughout the world. These sexually transmitted infections are a growing problem in people living with HIV/AIDS. However, the presence of these agents in extra genital sites, remains poorly studied in our country. The objective of this study was to estimate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae anal and genital infection in people living with HIV/AIDS followed in a reference center in Salvador, Brazil.  Methods: Cross-sectional study, from June 2013 to June 2015. Proven HIV-infected people attending this reference center were invited. Clinical and epidemiological data were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Chlamydia trachomatis; Neisseria gonorrhoeae; Sexually transmitted infections; Anogenital infections.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600569

Anoperineal tuberculosis in an HIV patient
Provedor de dados: 55
Autores: Antonello,Vicente Sperb; Hoff,Leonardo Santos; Kaercher Júnior,Darci; Santos,Breno Riegel.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300020

Antibacterial activity of Brazilian Amazon plant extracts
Provedor de dados: 55
Autores: Suffredini,Ivana Barbosa; Paciencia,Mateus Luís Barradas; Varella,Antonio Drauzio; Younes,Riad Naim.
Infections caused by multiresistant bacteria are a widespread problem, especially in intensive care units. New antibiotics are necessary, and we need to search for alternatives, including natural products. Brazil is one of the hottest spots in the world in terms of biodiversity, but little is known about the chemical and pharmacological properties of most of the plants found in the Amazon rain forest and the Atlantic Forest. We screened 1,220 organic and aqueous extracts, obtained from Amazon and Atlantic rain forest plants, against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and E. coli. Seventeen organic and aqueous extracts obtained from 16 plants showed activity against both Gram-positive bacteria. None of the extracts showed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Plant extract; Antibacterial activity; Amazon rain forest; Atlantic forest.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600008

Antibacterial effect of borage (Echium amoenum) on Staphylococcus aureus
Provedor de dados: 55
Autores: Abolhassani,Mohsen.
Borage (Echium amoenum) is a large annual plant of the Boraginaceae family, which grows in most of Europe and in northern Iran. The borage flower is used as a medicinal herb in France and other countries. Iranian borage is used in traditional medicine for infectious diseases, flu and as an anti-febrile. We tested the aqueous extract of borage dried flowers in vitro for its antibacterial activity. The extract showed concentration-dependent antibacterial activity against Staphylococcus aureus 8327. This activity was heat resistant, but the activity of freeze-dried extract gradually diminished during a 90-day period. The traditional use of Iranian borage flowers for infectious diseases and for controlling fever appears to be justified.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Borago; Echium amoenum; Antibacterial activity; Staphylococcus aureus.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500008

Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Latin America: results from the PROTEKT surveillance study (1999-2000)
Provedor de dados: 55
Autores: Mendes,C.; Marin,M. E.; Quiñones,F.; Sifuentes-Osornio,J.; Cuilty Siller,C.; Castanheira,M.; Zoccoli,C. M.; López,H.; Súcari,A.; Rossi,F.; Barriga Angulo,G.; Segura,A.J.A.; Starling,C.; Mimica,I.; Felmingham,D.
PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin) is a global surveillance study established in 1999 to monitor antibacterial resistance of respiratory tract organisms. Thirteen centers from Argentina, Brazil and Mexico participat ed during 1999-2000; they collected 1,806 isolates (Streptococcus pneumoniae 518, Haemophilus influenzae 520, Moraxella catarrhalis 140, Staphylococcus aureus 351, S. pyogenes 277). Overall, 218 (42.1%) of the S. pneumoniae isolates had reduced susceptibility to penicillin, 79 (15.3%) were penicillin-resistant and 79 (15.3%) were erythromycin-resistant. Mexico had the highest prevalence of penicillin (76.5%) and erythromycin (31.2%) resistance. Of 77 erythromycin-resistant S....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: PROTEKT; Latin America; Resistance; Respiratory tract infections; Streptococcus pneumoniae; Haemophilus influenzae; Moraxella catarrhalis; Streptococcus pyogenes; Staphylococcus aureus.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100006

Antibiotic prophylaxis in orthopedic surgeries: the results of an implemented protocol
Provedor de dados: 55
Autores: Queiroz,Raquel; Grinbaum,Renato S.; Galvão,Luciana L.; Tavares,Fernando G.; Bergsten-Mendes,Gun.
Though the basic principles of antibiotic prophylaxis have been well established, there is still considerable incorrect usage, including how much is prescribed and especially in the duration of treatment, which is generally superior to what is indicated. The adequate use of these drugs contributes towards decreasing the time of internment of the patient, prevents surgical site infection (SSI), decreasing the development of resistant microorganisms, and towards reduced costs for the hospital pharmacy. A protocol for the use of antibiotic prophylaxis in the Orthopedics and Traumatology Service of the Hospital do Servidor Público Estadual de São Paulo was developed. The objectives of the study were to promote rational antibiotic surgical prophylaxis, through...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotic prophylaxis; Protocol; Surgical site infection; Pharmacy.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400003

Antibiotic resistance and molecular typing of Pseudomonas aeruginosa: focus on imipenem
Provedor de dados: 55
Autores: Freitas,Ana Lúcia Peixoto de; Barth,Afonso Luis.
Susceptibility tests by disk diffusion and by E-test and molecular typing by macrorestriction analysis were performed to determine the relatedness of Pseudomonas aeruginosa isolates from three distinct hospitals. The resistance profile of 124 isolates to 8 antimicrobial agents was determined in three different hospitals, in Porto Alegre, Brazil. Frequencies of susceptibility ranged from 43.9% for carbenicillin to 87.7% for ceftazidime. Cross-resistance data of imipenem-resistant isolates indicated that most (70%) were also resistant to carbenicillin, although 30% remained susceptible to ceftazidime and cefepime. In general, susceptibility profiles were not able to determine relatedness among isolates of P. aeruginosa. On the other hand, molecular typing by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Antibiotic resistance; Imipenem.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100001

Antibiotic resistance patterns of pediatric community-acquired urinary infections
Provedor de dados: 55
Autores: Guidoni,Eliana Biondi Medeiros; Berezin,Eitan N.; Nigro,Stanley; Santiago,Nataly A; Benini,Vanda; Toporovski,Julio.
Knowledge about antimicrobial resistance patterns of the etiological agents of urinary tract infections (UTIs) is essential for appropriate therapy. Urinary isolates from symptomatic UTI cases attended at Santa Casa University Hospital of São Paulo from August 1986 to December 1989 and August 2004 to December 2005 were identified by conventional methods. Antimicrobial resistance testing was performed by Kirby Bauer's disc diffusion method. Among the 257 children, E. coli was found in 77%. A high prevalence of resistance was observed against ampicillin and TMP/SMX (55% and 51%). The antibiotic resistance rates for E. coli were: nitrofurantoin (6%), nalidixic acid (14%), 1st generation cephalosporin (13%), 3rd generation cephalosporins (5%), aminoglycosides...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urinary tract infection; Pediatrics urinary tract infection; Bacterial resistance; Escherichia coli.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400013

Antibiotics for the empirical treatment of acute infectious diarrhea in children
Provedor de dados: 55
Autores: Diniz-Santos,Daniel R.; Silva,Luciana R.; Silva,Nanci.
While the routine use of antibiotics for infectious diarrhea in children must be avoided, because it brings little benefit in most cases and is associated with the risk of increasing antimicrobial resistance, selected cases may require antimicrobial therapy, and the choice of the antimicrobial agent often has to be made empirically. Physicians prescribing antimicrobials in such a setting have not only to be aware of the most likely pathogens, but also of their characteristic antimicrobial susceptibility pattern and the safety profile of the various drugs. We reviewed the literature on the use of ampicillin, beta-lactamase inhibitors, trimethoprim-sulfamethoxazole, chloramphenicol, tetracyclines, nalidixic acid, fluoroquinolones, third-generation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Antibiotics; Children; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300011

Antibiotics produced by Streptomyces
Provedor de dados: 55
Autores: Procópio,Rudi Emerson de Lima; Silva,Ingrid Reis da; Martins,Mayra Kassawara; Azevedo,João Lúcio de; Araújo,Janete Magali de.
Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to produce bioactive secondary metabolites, such as antifungals, antivirals, antitumorals, anti-hypertensives, immunosuppressants, and especially antibiotics. The production of most antibiotics is species specific, and these secondary metabolites are important for Streptomyces species in order to compete with other microorganisms that come in contact, even within the same genre. Despite the success of the discovery of antibiotics,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptomyces; Antibiotics; Resistance; Infection.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500011

Antifibrotic therapy in chronic hepatitis C
Provedor de dados: 55
Autores: Siciliano,Rinaldo Focaccia; Barone,Antonio Alci.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700007

Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates
Provedor de dados: 55
Autores: Kubiça,Thaís Felli; Denardi,Laura Bedin; Azevedo,Maria Isabel; Oliveira,Vanessa; Severo,Luiz Carlos; Santurio,Janio Morais; Alves,Sydney Hartz.
ABSTRACT The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and caspofungin against 30 clinical isolates of both fluconazole-susceptible and fluconazole-resistant Trichosporon asahii. For these analyses, we used the broth microdilution method based on the M27-A3 technique and checkerboard microdilution method. Tacrolimus showed no activity against T. asahii strains (minimal inhibitory concentrations, MICs &gt; 64.0 µg mL−1). However, a larger synergistic interaction was observed by the combinations tacrolimus + amphotericin B (96.67%) and tacrolimus + caspofungin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Susceptibility; FK506; Resistance; Synergism.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600539

Antifungal activity of the lemongrass oil and citral against Candida spp.
Provedor de dados: 55
Autores: Silva,Cristiane de Bona da; Guterres,Sílvia S.; Weisheimer,Vanessa; Schapoval,Elfrides E.S.
Superficial mycoses of the skin are among the most common dermatological infections, and causative organisms include dermatophytic, yeasts, and non-dermatophytic filamentous fungi. The treatment is limited, for many reasons, and new drugs are necessary. Numerous essential oils have been tested for both in vitro and in vivo antifungal activity and some pose much potential as antifungal agents. By using disk diffusion assay, we evaluated the antifungal activity of lemongrass oil and citral against yeasts of Candida species (Candida albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis). This study showed that lemongrass oil and citral have a potent in vitro activity against Candida spp.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lemongrass oil; Citral; Antifungal activity; Candida spp.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100014

Antifungal efficacy of amphotericin B encapsulated fibrin microsphere for treating Cryptococcus neoformans infection in Swiss albino mice
Provedor de dados: 55
Autores: Khan,Azmat Ali; Jabeen,Mumtaz; Alanazi,Amer M; Khan,Abdul Arif.
Abstract A natural and biocompatible fibrin microsphere is one of the most promising dual delivery vehicle as compared to other traditionally designed delivery modalities. It represents sustained delivery of encapsulated drug and is easily biodegradable in the blood circulation. In the present study, we evaluated the systemic augmentation of the antifungal activity of amphotericin B loaded in fibrin microsphere (AMB-fibrin microsphere) against cryptococcosis in Swiss albino mice. Mice infected with Cryptococcus neoformans were treated with 0.5 mg/kg AMB-fibrin microsphere that was given alternately for 7 days. The antifungal potential of AMB-fibrin microsphere was assessed on the basis of reduction of cfu count in the systemic circulation and various vital...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphotericin B; Cryptococcosis; Fibrin microsphere; Cryptococcus neoformans.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400342

Antifungal pharmacodynamics: Latin America's perspective
Provedor de dados: 55
Autores: Gonzalez,Javier M.; Rodriguez,Carlos A.; Agudelo,Maria; Zuluaga,Andres F.; Vesga,Omar.
Abstract The current increment of invasive fungal infections and the availability of new broad-spectrum antifungal agents has increased the use of these agents by non-expert practitioners, without an impact on mortality. To improve efficacy while minimizing prescription errors and to reduce the high monetary cost to the health systems, the principles of pharmacokinetics (PK) and pharmacodynamics (PD) are necessary. A systematic review of the PD of antifungals agents was performed aiming at the practicing physician without expertise in this field. The initial section of this review focuses on the general concepts of antimicrobial PD. In vitro studies, fungal susceptibility and antifungal serum concentrations are related with different doses and dosing...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal agents; Pharmacology; Pharmacodynamics; Pharmacokinetics; Candidiasis; Aspergillosis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100079

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China
Provedor de dados: 55
Autores: Li,Meng; Liao,Yong; Chen,Min; Pan,Weihua; Weng,Lixing.
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp. complex isolates and their antifungal susceptibilities were investigated, including 52 C. neoformans and 9 C. gattii isolates collected at Shanghai between 1993 and 2009. Antifungal susceptibility of clinical isolates to amphotericin B, fluconazole, itraconazole, and flucytosine were determined by the microdilution method M27-A2 and the ATB FUNGUS 3 kit. The 90% minimum inhibitory concentration (MIC90) and susceptibility ranges were as follows: 1 (0.0625-1) µg/mL for amphotericin B, 4 (0.125-16) µg/ mL for fluconazole, 0.25 (0.0313-4) µg/mL for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcus neoformans; Cryptococcus gattii; Antifungal agents.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200012

Antifungal treatment with carvacrol and eugenol of oral candidiasis in immunosuppressed rats
Provedor de dados: 55
Autores: Chami,N.; Chami,F.; Bennis,S.; Trouillas,J.; Remmal,A.
Carvacrol and eugenol, the main (phenolic) components of essential oils of some aromatic plants, were evaluated for their therapeutic efficacy in the treatment of experimental oral candidiasis induced by Candida albicans in immunosuppressed rats. This anticandidal activity was analyzed by microbiological and histopathological techniques, and it was compared with that of nystatin, which was used as a positive control. Microbiologically, carvacrol and eugenol significantly (p&lt;0.05) reduced the number of colony forming units (CFU) sampled from the oral cavity of rats treated for eight consecutive days, compared to untreated control rats. Treatment with nystatin gave similar results. Histologically, the untreated control animals showed numerous hyphae on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carvacrol; Eugenol; Experimental oral candidiasis; Antifungal activity; Essential oils.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300005

Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report
Provedor de dados: 55
Autores: Monteiro,Eduardo José Bellotto; Caron,Daiane; Balda,Carlos Alberto; Franco,Marcello; Pereira,Aparecido Bernardo; Kirsztajn,Gianna Mastroianni.
We report on a case of a patient with HIV infection, diagnosed 18 months prior to the development of an anti-glomerular basement membrane (anti-GBM) rapidly progressive glomerulonephritis; this is probably the first report of such an association. A 30-year-old white man presented with elevation of serum creatinine (1.3 - 13.5 mg/dL within one month). At admission, the urinalysis showed proteinuria of 7.2 g/L and 8,000,000 erythrocytes/mL. Renal biopsy corresponded to a crescentic diffuse proliferative glomerulonephritis mediated by anti-GBM, and serum testing for anti-GBM antibodies was positive; antinuclear antibodies (ANA) and anti-neutrophilic cytoplasmic antibodies (ANCA) were also positive. The patient underwent hemodyalisis and was treated with...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Anti-GBM glomerulonephritis; HIV; Urinary abnormalities.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100011

Anti-hepatitis C virus treatment may prevent the progression of liver fibrosis in non-responder human immunodeficiency virus/hepatitis C virus coinfected patients
Provedor de dados: 55
Autores: Sagnelli,Caterina; Uberti-Foppa,Caterina; Galli,Laura; Pasquale,Giuseppe; Coppola,Nicola; Albarello,Luca; Doglioni,Carlo; Lazzarin,Adriano; Sagnelli,Evangelista.
AIM:To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon+Ribavirine regimen.MATERIALS AND METHODS:We investigated 49 patients with two sequential liver biopsies: 18 were non-responders to Interferon+Ribavirine treatment (Group hepatitis C virus Rx) administered after the 1st liver biopsy who underwent a 2nd liver biopsy after a median period of 3.92 year and 31 were patients who remained untreated for hepatitis C virus disease (Group hepatitis C virus untreated) after the 1st liver biopsy because of refusal and underwent a 2nd liver biopsy after a median period of 5.05-years. Most patients in both groups were under highly active antiretroviral therapy....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/HCV coinfection; HIV infection; HIV/HCV coinfection liver histology; Liver fibrosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200164

Antimicrobial activity of ceftobiprole against Gram-negative and Gram-positive pathogens: results from INVITA-A-CEFTO Brazilian study
Provedor de dados: 55
Autores: Cereda,Rosângela Ferraz; Azevedo,Heber Dias; Girardello,Raquel; Xavier,Danilo Elias; Gales,Ana C.
Ceftobiprole is a broad-spectrum cephalosporin with potent activity against staphylococci, including those resistant to oxacillin, as well as against most Gram-negative bacilli including Pseudomonas aeruginosa. In this study, the in vitro activity of ceftobiprole and comparator agents was tested against bacterial isolates recently collected from Brazilian private hospitals. A total of 336 unique bacterial isolates were collected from hospitalized patients between February 2008 and August 2009. Each hospital was asked to submit 100 single bacterial isolates responsible for causing blood, lower respiratory tract or skin and soft tissue infections. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using CLSI...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cephalosporins; Brazil; Gram-negative aerobic bacteria; Methicillin-resistant Staphylococcus aureus.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400007

Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study
Provedor de dados: 55
Autores: Gales,Ana Cristina; Azevedo,Heber D; Cereda,Rosângela Ferraz; Girardello,Raquel; Xavier,Danilo Elias.
In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intraabdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenems; Gram-negative bacteria; Brazil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600003

Antimicrobial activity of linezolid against Gram-positive cocci isolated in Brazil
Provedor de dados: 55
Autores: Sader,Helio S.; Gales,Ana C.; Jones,Ronald N.
The new oxazolidinone linezolid and other antimicrobial agents used to treat Gram-positive infections were tested against 1,585 Gram-positive cocci; 1,260 staphylococci and enterococci isolates from patients hospitalized in Brazilian hospitals, and 325 S. pneumoniae isolates for patients with community acquired infections. Susceptibility testing was performed using broth microdilution according to NCCLS procedures. Linezolid was the most active compound and the only drug that inhibited 100% of the isolates at the susceptible breakpoint (&lt; 4 mg/mL). Resistance to vancomycin was very rare (99.9% susceptibility), and both quinupristin/dalfopristin and gatifloxacin were active against approximately 90% of the strains evaluated. All other compounds inhibited...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gram-positive cocci; Oxazolidinones; Antimicrobial resistance; Linezolid; Vancomycin resistance; Nosocomial infections.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400002

Antimicrobial resistance and plasmid replicons in Yersinia enterocolitica strains isolated in Brazil in 30 years
Provedor de dados: 55
Autores: Frazão,Miliane R.; Andrade,Leonardo N.; Darini,Ana L.C.; Falcão,Juliana P.
Abstract Some studies evaluated the resistance profile of the Y. enterocolitica strains isolated in diverse countries. However, in Brazil the isolation and the study of Y. enterocolitica are not common and therefore information about the antimicrobial resistance profile of this species in this country is scarce. Therefore, the aim of this study was to evaluate the antimicrobial resistance of Y. enterocolitica of biotypes 1A, 2 and 4 isolated from clinical and non-clinical sources between 1979 and 2012, in Brazil. This study showed that some Yersinia enterocolitica of different biotypes remain susceptible to antimicrobials used for gastroenteritis treatment. Moreover, neither acquired resistance genes nor diversity of plasmids replicons were found; however,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Yersinia enterocolitica; Resistance profile; Plasmid replicon.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400477

Antimicrobial resistance in respiratory pathogens isolated in Brazil during 1999-2000
Provedor de dados: 55
Autores: Critchley,Ian A.; Blosser,Renée S.; Karlowsky,James A.; Yamakita,Juri; Barth,Alfonso; Sader,Helio S.; Mendes,Caio; Teixeira,Lucia; Rossi,Flavia; Dias,Cicero A. C.; Jones,Mark E.; Thornsberry,Clyde; Sahm,Daniel F.
The in vitro antimicrobial susceptibility of the respiratory pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis to commonly tested and prescribed agents was investigated during 1999-2000 and compared with results obtained during a previous 1997-1998 study. Of 448 isolates of S. pneumoniae collected and tested in 1999-2000, 77.2% were susceptible, 19.9% were intermediate, and 2.9% were resistant to penicillin, demonstrating that there were no major changes in susceptibility to penicillin from 1997-1998 (77.1% susceptible, 18.7% intermediate, 4.2% resistant). All S. pneumoniae isolates from 1999-2000 were susceptible to levofloxacin and vancomycin, and &gt;90% were susceptible to the beta-lactams (amoxicillin-clavulanate,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Antimicrobial resistance; Surveillance study; Respiratory pathogen.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600002

Antimicrobial resistance of clinical and environmental strains of Vibrio cholerae isolated in Lima-Peru during epidemics of 1991 and 1998
Provedor de dados: 55
Autores: Ibarra,J.O.; Alvarado,D.E.
The susceptibility in vitro of 71 isolations of V. cholerae was evaluated: 24 of clinical origin and 47 strains of clinical and environmental origin collected in the epidemic of 1991 and during the outbreak epidemic of 1998 in Lima-Peru respectively. The biochemical and serological tests carried out established that 43 (60,6%) corresponded to the serogroup O1 Ogawa of the 1998 epidemic; 26 (36.6%) were of the serotype Inaba, being 24 of them isolated in 1991. Two strains did not belong to the serogroup O1. By means of disk diffusion method and Minimal Inhibitory Concentration (MIC), 15 strains with multi-resistance to antibiotics were determined, 10 of which were of clinical origin and 5 of natural origin, showing 9 antibiotypes with different resistance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vibrio cholerae; Antimicrobial resistance; Cholera outbreak.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100022

Antimicrobial resistance of Pseudomonas aeruginosa in a Romanian hospital at the dawn of multidrug resistance
Provedor de dados: 55
Autores: Gavriliu,Liana-Catalina; Popescu,Gabriel-Adrian; Popescu,Cristina.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500509

Antimicrobial resistance profile of pathogens isolated from blood cultures in public and private hospitals in Brazil
Provedor de dados: 55
Autores: Fleming,Maria Emília Castro Kling de; Paula,Geraldo Renato de; Carballido,Jupira Miron; Mondino,Pedro Juan Jose; Barros,Rosana Rocha.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500024

Antimicrobial susceptibility associated with bloodstream infections in children: a referral hospital-based study
Provedor de dados: 55
Autores: Ashtiani,Mohammad Taghi Haghi; Mamishi,Setareh; Masoomi,Ahmad; Nasiri,Nafiseh; Hosseini,Mohammad; Nikmanesh,Bahram; Pourakbari,Babak; Rezaei,Nima.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400020

Antimicrobial susceptibility in intensive care units: MYSTIC Program Brazil 2002
Provedor de dados: 55
Autores: Mendes,Caio; Oplustil,Carmen; Sakagami,Elsa; Turner,Philip; Kiffer,Carlos.
OBJECTIVE: Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2002. MATERIAL AND METHODS: Gram-negative bacteria (n = 503) causing nosocomial infections were collected at seven Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by E-test methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). RESULTS: Pseudomonas aeruginosa (33%) was the most frequently isolated, followed by A. baumannii (17.1%), K. pneumoniae...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100008

Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Provedor de dados: 55
Autores: Fraga,Edmir Geraldo; Nicodemo,Antonio Carlos; Sampaio,Jorge Luiz Mello.
Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difficile; Disk diffusion; Agar dilution; Susceptibility testing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500476

Antimicrobial susceptibility of Gram-negative bacteria in Brazilian hospitals: the MYSTIC Program Brazil 2003
Provedor de dados: 55
Autores: Kiffer,Carlos; Hsiung,Andre; Oplustil,Carmen; Sampaio,Jorge; Sakagami,Elsa; Turner,Philip; Mendes,Caio.
Establish the susceptibility pattern of Gram-negative bacteria causing infections in ICU patients, MYSTIC Program Brazil 2003. Gram-negative bacteria (n = 1,550) causing nosocomial infections were collected at 20 Brazilian centers. The central laboratory confirmed the identification and performed the susceptibility tests by Etest methodology (AB Biodisk, Solna, Sweden) for meropenem, imipenem, ciprofloxacin, ceftazidime, cefepime, cefotaxime, piperacillin/tazobactam, gentamicin, and tobramycin. Interpretation criteria used were according to National Committee for Clinical Laboratory Standards (NCCLS). Pseudomonas aeruginosa (30.3%) was the most frequent isolate, followed by E. coli (18.6%), Klebsiella pneumoniae (16.9%), Acitenobacter baumannii (8.8%), and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance; Bacterial; Microbial sensitivity tests; Infection control; Carbapenems.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300004

Antimicrobial susceptibility of gram-positive bacteria isolated in brazilian hospitals participating in the SENTRY Program (2005-2008)
Provedor de dados: 55
Autores: Gales,Ana C.; Sader,Helio S.; Ribeiro,Julival; Zoccoli,Cassia; Barth,Afonso; Pignatari,Antonio C.
We report the antimicrobial susceptibility patterns of the most frequently isolated Gram-positive bacteria in the Brazilian hospitals participating in the SENTRYAntimicrobial Surveillance Program. The strains were consecutively collected (one per patient) between January 2005 and September 2008 and susceptibility tested by reference broth microdilution methods at the JMI Laboratories (North Liberty, Iowa, USA). A total of 3,907 Gram-positive cocci were analyzed. The Gram-positive organisms most frequently isolated from bloodstream infections were Staphylococcus aureus (2,218 strains; 20.2% of total), coagulase-negative staphylococci (CoNS; 812 strains [14.7%]), and Enterococcus spp. (754 strains; 5.0%). S. aureus ranked first (28.1%) and Enterococcus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial resistance; SENTRY; Nosocomial infections; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200004

Antimicrobial susceptibility of hospital acquired Stenotrophomonas maltophilia isolate biofilms
Provedor de dados: 55
Autores: Sun,Erlin; Liang,Gehong; Wang,Lining; Wei,Wenjie; Lei,Mingde; Song,Shiduo; Han,Ruifa; Wang,Yubao; Qi,Wei.
Abstract  Aims We sought to characterize the antibiotic susceptibility of strains of Stenotrophomonas maltophilia isolated from clinical samples, and the role of Stenotrophomonas maltophilia biofilm in antibiotic resistance.  Methods Fifty-one clinical Stenotrophomonas maltophilia isolates were obtained from patients with nosocomial infection in the surgical wards and ICUs of six general hospitals in Tianjin, China. In vitro models of Stenotrophomonas maltophilia biofilms were established and confirmed by scanning electron microscopy and fluorescence microscopy with silver staining. The minimal inhibitory concentrations and biofilm inhibitory concentrations of commonly used antibiotics were determined.  Results 47 of 51 strains were resistant to three or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Stenotrophomonas maltophilia; Biofilm; Antibiotic resistance; Nosocomial.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400365

Antimicrobial susceptibility of quinupristin/dalfopristin tested against gram-positive cocci from Latin America: results from the Global SMART (GSMART) surveillance study
Provedor de dados: 55
Autores: Sader,Helio S.; Jones,Ronald N.; Ballow,Charles H.; Biedenbach,Douglas J.; Cereda,Rosangela F.
Gram-positive cocci are important causes of both nosocomial and community-acquired infections, and antimicrobial resistance among these pathogens has become an important problem worldwide. Since resistance among these organisms can vary substantially by geographic location, we conducted a multicenter surveillance study with isolates from five Latin American countries (15 medical centers). Quinupristin/dalfopristin (formerly RP-59500) is a novel streptogramin combination with focused activity against Gram-positive cocci, many exhibiting emerging resistance. The in vitro activity of quinupristin/dalfopristin and 12 other antimicrobial agents were evaluated against 1,948 strains including Staphylococcus aureus (747 strains), coagulase-negative staphylococci...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quinupristin/dalfopristin; Gram-positive cocci; SMART; Antimicrobial surveillance.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100004

Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections
Provedor de dados: 55
Autores: Yu,Fangyou; Liu,Yunling; Lv,Jinnan; Qi,Xiuqin; Lu,Chaohui; Ding,Yu; Li,Dan; Liu,Huanle; Wang,Liangxing.
ABSTRACT A better understanding of the antimicrobial susceptibility, carriage of virulence determinants and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections (SSTIs) may provide further insights related to clinical outcomes with these infections. From January 2012 to September 2013, a total of 128 non-duplicateS. aureus isolates were recovered from patients with SSTIs. All 128 S. aureus SSTI isolates carried at least five virulence genes tested. Virulence genes detected among at least 70% of all tested isolates included hld (100%), hla (95.3%),icaA (96.9%), clf (99.2%),sdrC (79.7%), sdrD (70.3%), andsdrE (72.7%). The prevalence of MRSA isolates with 10 virulence genes tested (54.4%, 31/56) was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Skin and soft tissue infections; Molecular characteristic; Virulence genes.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600614

Antimicrobial therapy for community-acquired pneumonia in adults
Provedor de dados: 55
Autores: Cunha,Clovis Arns da; Sader,Helio S.; Nicodemo,Antonio C.
This is part of the series of practice guidelines commissioned by the Brazilian Society for Infectious Diseases through its Practice Guidelines Committee. The purpose of these guidelines is to provide assistance to clinicians in the antimicrobial treatment of community-acquired pneumonia (CAP) in immunocompetent adults. Panel members and consultants are experts in adult infectious diseases. The guidelines are evidence based where possible. The recommendations included in this document were elaborated based on the most frequently isolated pathogens and their antimicrobial susceptibilities. The etiology was based mainly on international studies, since there are very few regional data. On the other hand, the antimicrobial susceptibilities of main bacterial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-Acquired Pneumonia; Guidelines; Brazilian Society for Infectious Diseases.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200004

Antimicrobials and renal failure in neutropenic patients
Provedor de dados: 55
Autores: França,Monique Sedlmaier; Lima,Stella Sala Soares; Duclou,Caroline Naback; Goulart,Eugênio Marcos Andrade; Romanelli,Roberta Maia de Castro.
Antimicrobial treatment is often indicated to neutropenic patients. Although renal failure is a common complication of many antibiotics, no information could be found in the literature defining which are the best screening criteria for detecting renal injury. In this paper, the authors aim to assess the progress to renal failure in neutropenic patients on antimicrobial use and to compare different diagnostic criteria of renal failure in association to antimicrobial agents used. This is a cohort study conducted from February to August 2006 at the Hospital das Clínicas of the Universidade Federal de Minas Gerais, which included patients with neutropenia and antimicrobial therapy for the treatment of Healthcare Associated Infections notified by the Hospital...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Neutropenia; Renal insufficiency; Antimicrobial agents.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400016

Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro
Provedor de dados: 55
Autores: Brilhante,Raimunda Sâmia Nogueira; Caetano,Érica Pacheco; Riello,Giovanna Barbosa; Guedes,Glaucia Morgana de Melo; Castelo-Branco,Débora de Souza Collares Maia; Fechine,Maria Auxiliadora Bezerra; Oliveira,Jonathas Sales de; Camargo,Zoilo Pires de; Mesquita,Jacó Ricarte Lima de; Monteiro,André Jalles; Cordeiro,Rossana de Aguiar; Rocha,Marcos Fábio Gadelha; Sidrim,José Júlio Costa.
Abstract Recent studies have shown that some drugs that are not routinely used to treat fungal infections have antifungal activity, such as protease inhibitor antiretroviral drugs. This study investigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavir and ritonavir, and its combination with the antifungal itraconazole. The susceptibility assay was performed according to Clinical and Laboratory Standards Institute guidelines. All strains were inhibited by the protease inhibitor antiretroviral drugs. Saquinavir showed minimum inhibitory concentrations ranging from 0.125 to 1 μg mL−1 for both phases, and ritonavir presented minimum inhibitory concentrations ranging from 0.0312 to 4 μg mL−1and from 0.0625 to 1 μg mL−1 for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histoplasma capsulatum; Saquinavir; Ritonavir; Itraconazole.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200155

Antiretroviral therapy during pregnancy and early neonatal life: consequences for HIV-exposed, uninfected children
Provedor de dados: 55
Autores: El Beitune,Patrícia; Duarte,Geraldo; Quintana,Silvana Maria; Figueiró-Filho,Ernesto A.; Marcolin,Alessandra Cristina; Abduch,Renata.
Women have emerged as the fastest growing human immunodeficiency virus (HIV) infected population worldwide, mainly because of the increasing occurrence of heterosexual transmission. Most infected women are of reproductive age and one of the greatest concerns for both women and their physicians is that more than 1,600 infants become infected with HIV each day. Almost all infections are a result of mother-to-child transmission of HIV. With the advent of combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. Antiretroviral compounds differ from most other new pharmaceutical agents in that they have become widely prescribed in pregnancy in the absence of proof of safety. We reviewed antiretroviral agents...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Exposed; Infant; Consequences; Antiretroviral.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200004

Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers
Provedor de dados: 55
Autores: Coelho,Antonio V.C.; Moura,Ronald R. de; Guimarães,Rafael L.; Brandão,Lucas A.C.; Crovella,Sergio.
ABSTRACT  Background: Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving viral suppression. The genetic component of this condition is not yet completely elucidated.  Objective: To identify predictive genetic markers of immune response to ART.  Methods: Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Pharmacodynamics; Immunogenetics; Genetic association study; Survival analysis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500392

Anti-Trypanosoma cruzi antibody detection in blood donors in the Southern Brazil
Provedor de dados: 55
Autores: Araújo,A.B.; Vianna,E.E.S.; Berne,M.E.A.
Trypanosoma cruzi, the causal agent of Chagas' Disease, is a widely spread protozoa in America. Blood transfusion is the secondly most important way of acquiring the infection. In blood banks, tests are performed to eliminate potentially infected blood. This study aimed to evaluate the positivity for T. cruzi in blood samples of donor's candidates in Southern Brazil. The study was based on a sampling containing all blood donors of Hemopel - a Pelotas City Blood Center, Rio Grande do Sul State, Brazil, from 2004 to 2005. Serological study was performed using ELISA Chagatest. Sampling containing values ± 20% cut off were evaluated using ELISA Chagatek, ELISA Alka/Adaltis, IHA Chagatest and IIF Imunocruzi. TESA-Blot was used as a confirmatory procedure in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Blood donors; Serological screening.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600007

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia
Provedor de dados: 55
Autores: Matos,Eliana Dias; Lemos,Antônio Carlos Moreira; Bittencourt,Carolina; Mesquita,Cristiane Leite.
Anti-tuberculosis drug resistance, particularly multiresistance, is a crucial issue in the control of tuberculosis (TB). This study estimated the prevalence of primary and acquired anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from hospitalized patients, to identify the risk factors for resistance, and to evaluate the its impact on hospital mortality for tuberculosis. Strains of Mycobacterium tuberculosis from 217 patients hospitalized for TB were analyzed. Subjects were recruited sequentially at a TB reference hospital in Salvador, Bahia, Brazil from July 2001 to July 2003. Multiresistant (MR) strains were defined as strains resistant to rifampicin and isoniazid. Of a total of 217 strains isolated, 41 (19.0%, 95%CI:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Tuberculosis; Resistance; Multiresistance; Hospitals; Bahia-Brazil.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300007

Antiviral targeting of NF-kB: a potential therapy for HIV and herpesvirus associated lymphomas
Provedor de dados: 55
Autores: Harrington, Jr.,William J.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500013

Apoptosis and progression of hepatic fibrosis in hepatitis C patients
Provedor de dados: 55
Autores: Schinoni,Maria Isabel; Paraná,Raymundo; Cavalcante,Daniel.
Hepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apoptosis; Hepatitis C; Liver fibrosis.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009

Applicability of the national nosocomial infections surveillance system risk index for the prediction of surgical site infections: a review
Provedor de dados: 55
Autores: Ercole,Flávia Falci; Starling,Carlos Ernesto Ferreira; Chianca,Tânia Couto Machado; Carneiro,Mariângela.
This review outlines the evolution of risk rates of surgical site infection adopted by the Study on the Efficacy of Nosocomial Infection Control (SENIC) and the National Nosocomial Infections Surveillance (NNIS) system, and evaluates their advantages and limitations. The types of surgical procedures for which the NNIS index has proven to be an efficient system for the classification of patients are presented. The necessity of adapting the NNIS index to take into account specific characteristics associated with hospitals and practices in various regions and countries is stressed. The requirement for further testing and development of the rate concerning specific procedures, particularly those involving orthopaedic surgery, is discussed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SSI/NNIS Index; Quality indicators; Hospital infections; Surgical procedures; Orthopaedic operations.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100028

Application of the ATLAS score for evaluating the severity of Clostridium difﬁcile infection in teaching hospitals in Mexico
Provedor de dados: 55
Autores: Hernández-García,Raúl; Garza-González,Elvira; Miller,Mark; Arteaga-Muller,Giovanna; Galván-de los Santos,Alejandra María; Camacho-Ortiz,Adrián.
Background: For clinicians, a practical bedside tool for severity assessment and prognosis of patients with Clostridium difﬁcileinfection is a highly desirable unmet medical need.Setting: Two general teaching hospitals in northeast Mexico.Population: Adult patients with C. difﬁcileinfection.Methods: Prospective observational study.Results: Patients included had a median of 48 years of age, 54% of male gender and an average of 24.3 days length of hospital stay. Third generation cephalosporins were the antibiotics most commonly used prior to C. difﬁcileinfection diagnosis. Patients diagnosed with C. difﬁcileinfection had a median ATLAS score of 4 and 56.7% of the subjects had a score between 4 and 7 points. Patients with a score of 8 through 10 points had...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difﬁcile; Prediction rule; Mortality.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400399

Apropos "Rotavirus infection in a tertiary hospital: laboratory diagnosis and impact of immunization on pediatric hospitalization"
Provedor de dados: 55
Autores: Arya,Subhash C.; Agarwal,Nirmala.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300018

Aptamers as a promising approach for the control of parasitic diseases
Provedor de dados: 55
Autores: Ospina-Villa,Juan David; Zamorano-Carrillo,Absalom; Castañón-Sánchez,Carlos A.; Ramírez-Moreno,Esther; Marchat,Laurence A.
ABSTRACT Aptamers are short single-stranded RNA or DNA oligonucleotides that are capable of binding various biological targets with high affinity and specificity. Their identification initially relies on a molecular process named SELEX (Systematic Evolution of Ligands by EXponential enrichment) that has been later modified in order to improve aptamer sensitivity, minimize duration and cost of the assay, as well as increase target types. Several biochemical modifications can help to enhance aptamer stability without affecting significantly target interaction. As a result, aptamers have generated a large interest as promising tools to compete with monoclonal antibodies for detection and inhibition of specific markers of human diseases. One aptamer-based drug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aptamer; Parasite control; Protozoan parasite; SELEX strategy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600610

Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine
Provedor de dados: 55
Autores: Mishra,Nripendra Nath; Ali,Shakir; Shukla,Praveen K.
Candida albicans utilizes arachidonic acid (AA) released during the course of infection (Candidiasis) from phospholipids of infected host cell membranes and synthesizes extracellular prostaglandin(s) which play an important role in hyphae formation and host cell damage. C. albicans biofilms secrete significantly more prostaglandin(s) and evidence suggests that Candida biofilms have dramatically reduced susceptibility to majority of antifungal drugs. AA influences the saturation level of lipids and fluidity of yeast cell membranes. Therefore the aim of this study was to evaluate the effect of AA alone or in combination with antifungal agents on biofilm formation and production of prostaglandin (PGE2) in C. albicans, C. parapsilosis, C. glabrata, C....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Arachidonic acid; Candida albicans; AmBR; Candida tropicalis; Prostaglandin E2; FDA.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300287

Are anti-interferon antibodies the cause of failure in: chronic HCV hepatitis treatment?
Provedor de dados: 55
Autores: Barone,Antonio Alci; Tosta,Rose Aparecida Borges; Tengan,Fátima Mitiko; Marins,José Humberto Caetano; Cavalheiro,Norma de Paula; Cardi,Bruno Andrade.
A follow-up study was made of 94 chronic hepatitis C patients at a hepatitis clinic in Brazil, after interferon alpha (IFN-alpha) therapy, to determine the influence of anti-interferon antibodies on treatment outcome. Patients diagnosed as having chronic hepatitis C, confirmed by PCR (HCV RNA) and liver biopsy, were treated with interferon alpha 2a or 2b for at least six months, and were followed up for 24 weeks after termination of treatment in order to assess biochemical, virological and clinical pathology responses. Only 6% of the 94 patients developed anti-IFN antibodies, 70% presented a biochemical response and 23% maintained a sustained virological response. Clinical evaluation revealed that in only 2 patients was there progression of fibrosis; the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon-alpha; Antibodies; Chronic HCV; Treatment.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100002

Are opossums a relevant factor associated with asymptomatic Leishmania infection in the outskirts of the largest Brazilian cities?
Provedor de dados: 55
Autores: Carranza-Tamayo,César Omar; Werneck,Guilherme Loureiro; Romero,Gustavo Adolfo Sierra.
Abstract A population survey was conducted to explore the prevalence and factors associated with Leishmania infection in the Fercal region of the Federal District. The Fercal region is a group of neighborhoods in Brasília in which the first cases of visceral leishmaniasis were described. Leishmania infection was established by a positive leishmanin test. Although other tests were performed in the study (an immunochromatographic assay (Kalazar detect®) and a molecular assay), only the leishmanin skin test provided sufficient results for the measurement of the disease prevalence. Data on the epidemiological, clinical and environmental characteristics of individuals were collected along with the diagnostic tests. After sampling and enrollment, seven hundred...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; Brazil; Didelphis albiventris; Leishmanin.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200119

Are traditional body fat equations and anthropometry valid to estimate body fat in children and adolescents living with HIV?
Provedor de dados: 55
Autores: Lima,Luiz Rodrigo Augustemak de; Martins,Priscila Custódio; Alves Junior,Carlos Alencar Souza; Castro,João Antônio Chula de; Silva,Diego Augusto Santos; Petroski,Edio Luiz.
Abstract The aim of this study was to assess the validity of traditional anthropometric equations and to develop predictive equations of total body and trunk fat for children and adolescents living with HIV based on anthropometric measurements. Forty-eight children and adolescents of both sexes (24 boys) aged 7-17 years, living in Santa Catarina, Brazil, participated in the study. Dual-energy X-ray absorptiometry was used as the reference method to evaluate total body and trunk fat. Height, body weight, circumferences and triceps, subscapular, abdominal and calf skinfolds were measured. The traditional equations of Lohman and Slaughter were used to estimate body fat. Multiple regression models were fitted to predict total body fat (Model 1) and trunk fat...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Body fat; HIV; Skinfold thickness; Anthropometry; DXA.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400448

Arrhythmias in leptospirosis-associated acute kidney injury: a case series
Provedor de dados: 55
Autores: Soares,Douglas de Sousa; Galdino,Gabriela Studart; Rodrigues,Bruna Custódio; Silva Junior,Geraldo Bezerra da; Daher,Elizabeth De Francesco.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200209

Arthralgia and scaly rashes over the palms and the soles
Provedor de dados: 55
Autores: Tan,Cheng; Zhu,Wen-Yuan.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500505

Aspartate aminotransferase-to-platelet ratio index for fibrosis and cirrhosis prediction in chronic hepatitis C patients
Provedor de dados: 55
Autores: Silva Junior,Roberto Gomes da; Fakhouri,Ricardo; Nascimento,Tereza Virgínia Bezerra do; Santos,Igor Martins; Barbosa,Luciana Mendonça Morais.
In chronic hepatitis C (CHC), liver biopsy is the gold standard method for assessing liver histology, however it is invasive and can have complications. Non-invasive markers have been proposed and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) has been shown as an easy and inexpensive marker of liver fibrosis. This study evaluated the diagnostic performance of APRI for significant fibrosis and cirrhosis prediction in CHC patients. This study included treatment-naive CHC patients who had undergone liver biopsy from January 2000 to August 2006. All histological slides were reviewed according to the METAVIR system. APRI was calculated based on laboratory results performed within four months from the biopsy. Twenty-eight (56%) patients had...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Fibrosis; Cirrhosis; Liver biopsy; AP.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100005

Aspergillus niger – a possible new etiopathogenic agent in Tinea capitis? Presentation of two cases
Provedor de dados: 55
Autores: Chokoeva,Anastasiya Atanasova; Zisova,Liliya; Chorleva,Kristina; Tchernev,Georgi.
Abstract Tinea capitis is generally considered as the most frequent fungal infection in childhood, as it accounts for approximately 92% of all mycosis in children. The epidemiology of this disease varies widely ranging from antropophillic, zoophilic, and geophillic dermatophytes, as the main causative agent in different geographic areas, depending on several additional factors. Nowadays, the etiology is considered to vary with age, as well with gender, and general health condition. The former reported extraordinary Tinea capitis case reports have been replaced by original articles and researches dealing with progressively changing patterns in etiology and clinical manifestation of the disease. This fact is indicative that under the umbrella of the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tinea capitis; Children; Etiology; Molds.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300015

Assessing and screening for T-cell epitopes from Mycobacterium tuberculosis RD2 proteins for the diagnosis of active tuberculosis
Provedor de dados: 55
Autores: Chen,Jiazhen; Ruan,Qiaoling; Shen,Yaojie; Wang,Sen; Shao,Lingyun; Zhang,Wenhong.
ABSTRACT The Region of D eletion 2 (RD2) of Mycobacterium tuberculosis encodes reserved antigens that contribute to bacterial virulence. Among these antigens, Rv1983, Rv1986, Rv1987, and Rv1989c have been shown to be immunodominant in infected cattle; however, their diagnostic utility has not been evaluated in humans.In this study, we screened 87 overlapping synthetic peptides encoded by five RD2 proteins for diagnosing tuberculosis epitopes in 50 active tuberculosis (TB) cases, 31 non-tuberculosis patients and 36 healthy individuals. A pool of promising epitopes was then assessed for their diagnostic value in 233 suspected TB patients using a whole blood IFN-γ release assay.Only 10 peptides were recognized by more than 10% of active tuberculosis patients....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; T-cell epitope; Diagnostic antigen.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600462

Assessing new strategies for TB diagnosis in low- and middle-income countries
Provedor de dados: 55
Autores: Kritski,Afrânio; Fujiwara,Paula I.; Vieira,Maria Armanda; Netto,Antonio Ruffino; Oliveira,Martha Maria; Huf,Gisele; Squire,S. Bertel.
In this manuscript, we report the current situation of tuberculosis globally and in Brazil, the need for new strategies toward tuberculosis control, focusing on new diagnostic technologies. Critical comments are given on the state of the art regarding the evaluation of new health technologies, degree of scientific evidence needed, evaluation of clinical impact, cost-effectiveness of incorporation into the health system and the social impact.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Diagnostics; Impact; Evidence; Policy; Innovation; Regulatory agency.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200015

Assessing risk behaviors and prevalence of sexually transmitted and blood-borne infections among female crack cocaine users in salvador - Bahia, Brazil
Provedor de dados: 55
Autores: Nunes,Ceuci L.X.; Andrade,Tarcisio; Galvão-Castro,Bernardo; Bastos,Francisco I.; Reingold,Arthur.
Crack cocaine use is associated with risky sexual behaviors and sexually transmitted infections (STIs), including HIV. We investigated sociodemographic and behavioral characteristics and infection rates in female crack cocaine users from impoverished communities of Salvador, Bahia, Brazil. A sample of 125 female crack cocaine users was recruited. Overall, the interviewees had low educational level and high rate of unemployment (close to 90%). One-third (37%) reported having traded sex for money or drugs, and 58% reported that they had not used condoms during intercourse in the last 30 days. The prevalence of infections was low: HIV-1.6%; HCV-2.4%; HBV- 0.8%; HTLV I/II-4.0%; and syphilis-4.0%. The combination of dire poverty and high prevalence of risk...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risk behaviors; Prevalence of sexually transmitted and blood-borne infections; Female crack cocaine users.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600007

Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia
Provedor de dados: 55
Autores: Mohamad,Suharni; Deris,Zakuan Zainy; Yusoff,Nik Khairulddin; Ariffin,Tg Ahmad Akram Tg Mohd; Shueb,Rafidah Hanim.
Antiretroviral (ARV) therapy has dramatically reduced morbidity and mortality in human immunodeficiency virus 1 (HIV-1) infected children. However, development of ARV resistance in these children is a major public health problem due to lack of availability of and access to new drugs. This study was conducted in order to identify circulating HIV subtypes and recombinant forms and evaluate the drug resistance mutation patterns in 18 HIV-1 infected children failing ARV treatment in Kelantan, Malaysia. Genotyping for codon 1-99 of protease (PR) and 1-250 of reverse transcriptase (RT) were performed by polymerase chain reaction (PCR) amplification and DNA sequencing. Subsequently, these were phylogenetically analyzed to determine the subtypes. CRF33_01B (44.4%)...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV-1 subtype; Resistance mutation; Children.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300012

Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia
Provedor de dados: 55
Autores: Villegas,Maria Virginia; Briceno,David Felipe; Ruiz,Sory Jamil; Furtado,Guilherme H; Nicolau,David P.
OBJECTIVES: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC distribution data to determine which of the tested carbapenem regimens provided the greatest opportunity for obtaining maximal pharmacodynamic (PD) activity. METHODS: The isolates studied were obtained from the COMPACT-COLOMBIA surveillance program conducted between February and November 2009. Antimicrobial susceptibility testing was conducted by broth microdilution method according to the CLSI guidelines. Doripenem, imipenem-cilastatin, and meropenem, were the modeled antibiotics. A 5,000 patient Monte...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance; Bacterial; Gram-negative bacteria; Monte Carlo Method; Colombia; Pharmacology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500001

Assessing the present and future roles of infectious diseases specialists in treating infections
Provedor de dados: 55
Autores: Costa,Paulo Sérgio Gonçalves da.
Tipo: Info:eu-repo/semantics/article
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500008

Assessment of an intervention aimed at early discontinuation of intravenous antimicrobial therapy in a Brazilian University hospital
Provedor de dados: 55
Autores: Bonella,Gislaine Ferraresi; Fontes,Astrídia Marília de Souza; Jorge,Miguel Tanús; Silveira,Alexandre Barcelos Morais da.
Abstract Many interventions demonstrate success in adapting the duration of intravenous antibiotic therapy, but few studies have been conducted in developing countries. The aim of this study was to evaluate the effectiveness of an intervention in the induction of early discontinuation of intravenous antimicrobial therapy and/or its switch to oral therapy. The study employed a before–after intervention design that consisted of displaying a message in the computerized prescription on the third day and suspension of the prescription on the fifth day of intravenous antimicrobial therapy. A total of 465 patients were followed during the control period (CP) and 440 in the intervention period (IP). The intravenous therapy was switched to oral therapy for 11...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Intravenous administration; Oral administration; Inappropriate prescribing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500462

Assessment of antioxidants status and superoxide dismutase activity in HIV-infected children
Provedor de dados: 55
Autores: Pugliese,Camila; Patin,Rose Vega; Palchetti,Cecilia Zanin; Claudio,Cristiane Chiantelli; Gouvêa,Aída de Fátima Thomé Barbosa; Succi,Regina Célia de Menezes; Amancio,Olga Maria Silverio; Cozzolino,Silvia Maria Franciscato; Oliveira,Fernanda Luisa Ceragioli.
Objective:This study aims to assess the nutritional status of selenium, copper and zinc; and also the erythrocyte superoxide dismutase activity of HIV-infected children compared to a control group.Methods:A cross-sectional study was carried out with prepubertal HIV-infected children (n = 51) and their healthy siblings (n = 32). All biochemical measurements including plasma selenium, serum copper levels, serum and erythrocyte zinc levels and erythrocyte super-oxide dismutase activity were evaluated according to dietary, clinical and biochemical parameters.Results:Compared to the control group, the HIV-infected children had lower z-score values for height-for-age (p = 0.0006), higher prevalence of stunting (11.8%) (p = 0.047), lower selenium levels (p =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidants; HIV and nutrition; Oxidative stress; Trace elements.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500481

Assessment of conventional PCR and real-time PCR compared to the gold standard method for screening Streptococcus agalactiae in pregnant women
Provedor de dados: 55
Autores: Ferreira,Michele Berger; de-Paris,Fernanda; Paiva,Rodrigo Minuto; Nunes,Luciana de Souza.
ABSTRACT Group B Streptococcus is a causative agent of invasive neonatal infections. Maternal colonization by Streptococcus agalactiae is a necessary condition for vertical transmission, with efficient screening of pregnant women playing an essential role in the prevention of neonatal infections. In this study, we aimed to compare the performance of conventional polymerase chain reaction and real-time PCR assays as screening methods for S. agalactiae in pregnant women against the microbiological culture method considered as the gold-standard. A total of 130 samples from pregnant women were analyzed for sensitivity, specificity, positive predictive value, and negative predictive value. Statistical analysis was performed using the SPSS software, version...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus agalactiae; Pregnant women; Screening; Conventional PCR; Real-time PCR.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600449

Assessment of family and neighbors of an individual infected with Wuchereria bancrofti from a non-endemic area in the city of Maceió, Brazil
Provedor de dados: 55
Autores: Leite,Anderson B; Lima,Ana RV de; Leite,Renata B; Santos,Rafael V; Gonçalves,Johnathan EL; Rocha,Eliana MM; Fontes,Gilberto.
The family and neighbors of a patient infected with W. bancrofti microfilariae were assessed aiming to evaluate the occurrence of cases of lymphatic filariasis in a non-endemic area in the city of Maceió, in the Brazilian state of Alagoas. The patient had previously lived in an endemic focus; however, he has been living in an area where the parasite has never been detected for the past ten years. Female ingurgitated Culex quinquefasciatus mosquitoes captured in the houses of the microfilaremic individual and of his neighbors in the non-endemic region were also examined by polymerase chain reaction (PCR) technique. The thick blood smear examination, blood membrane filtration, and rapid immunochromatography (antigen search) revealed no infected individuals...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Wuchereria bancrofti; Lymphatic filariasis; Epidemiology; Culex.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200002

Assessment of health-related quality of life and related factors in patients with chronic liver disease
Provedor de dados: 55
Autores: Souza,Neila Paula de; Villar,Livia Melo; Garbin,Artênio José Ísper; Rovida,Tânia Adas Saliba; Garbin,Cléa Adas Saliba.
ABSTRACT  BACKGROUND AND OBJECTIVES:  Assessing health-related quality of life is an important aspect of clinical practice. Thus, the present study attempts to assess the health-related quality of life of patients with chronic liver disease.  METHODS:  A cross-sectional survey was conducted on 133 chronic liver disease patients, using three instruments: a demographic questionnaire, the Chronic Liver Disease Questionnaire, and Model for End-Stage Liver Disease index. Variables were expressed as frequencies, percentages, means, and standard deviations. The statistical analysis included Pearson's correlation, Student's t-test, and analysis of variance (p &lt; 0.05 was considered significant).  RESULTS:  The mean age of included subjects was 50.5 ± 13.3 years....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quality of life; Hepatitis; Liver cirrhosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600590

Assessment of hospital daily cleaning practices using ATP bioluminescence in a developing country
Provedor de dados: 55
Autores: Zambrano,Alejandra A.; Jones,Alex; Otero,Paula; Ajenjo,Maria Cristina; Labarca,Jaime A.
Visual assessment of surfaces may not be enough to document the level of cleanliness in the hospital setting. It is necessary to introduce quantitative methods to document the results of this practice.Objective:To evaluate the efficacy of hospital terminal cleaning procedures, using an adenosine triphosphate (ATP) bioluminescence method in a teaching hospital.Method:During 2008 we conducted an evaluation using ATP bioluminescence LIGHTNING MVP™ (Arquimed) of external and internal housekeeping service. After conducting an initial evaluation we implemented education of cleaning practices and finally we did a post intervention evaluation. Using chi-square method we compared prior versus after cleaning, quality of cleaning performed by external versus internal...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: ATP bioluminescence; Cleaning; Bacterial resistance; Nosocomial infections.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600675

Assessment of sexual risk behaviors and perception of vulnerability to sexually transmitted diseases/acquired immunodeficiency syndrome in women, 1999-2012: a population based survey in a medium-sized Brazilian city
Provedor de dados: 55
Autores: Mesenburg,Marilia Arndt; Muniz,Ludmila Correa; Silveira,Mariângela Freitas.
Sexual behavior is a key factor for susceptibility to sexually transmitted diseases. An evaluation of the sexual behavior of women at reproductive age was conducted in 1999. A replication of this study aims to evaluate the current situation and identify changes in sexual behavior, 13 years later. This is a population-based cross-sectional study, conducted with 1071 women in Pelotas, Brazil. Compared to the 1999 study, a 14% increase in early sexual debut and an 8% decrease in the non-use of condoms were observed in 2012. The proportion of women who reported anal sex doubled between these periods. There was no trend of increase or decrease in the prevalence of behaviors with distinct patterns being observed for each of them. Reduction of non-use of condoms...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually transmitted diseases; Behavior; Risk factors; Women.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400414

Assessment of the effectiveness of a home-based care program for patients coinfected with tuberculosis and human immunodeficiency virus after discharge from a reference hospital in South-Eastern Brazil
Provedor de dados: 55
Autores: Bento,Carlos Alessandro Plá; Pedroso,Enio Roberto Pietra.
The effectiveness of tuberculosis treatment delivered by a home-based care program to patients coinfected with HIV was compared with that of a service provided by outpatient departments. A retrospective study was made of a cohort of coinfected patients discharged from hospital between January 1998 and December 2002 who had been followed-up for one year within one of these programs. Two-hundred-and-forty-three patients who met the inclusion criteria were grouped according to their treatment program (group 1 received home-based care; group 2 attended outpatient departments) and then paired one-to-one across the groups by gender, age and level of education. Only 48 patients from each group could be paired. Apart from the duration of HIV infection, there were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Tuberculosis; Treatment outcome; Adherence to treatment; Home-based care.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600008

Assessment of the effectiveness of a ventilator associated pneumonia prevention bundle that contains endotracheal tube with subglottic drainage and cuff pressure monitorization
Provedor de dados: 55
Autores: Akdogan,Ozlem; Ersoy,Yasemin; Kuzucu,Ciğdem; Gedik,Ender; Togal,Turkan; Yetkin,Funda.
ABSTRACT The effectiveness of prevention bundles on the occurrence and mortality of ventilator associated pneumonia (VAP) was evaluated in many studies. However, the effectiveness of endotracheal tube with subglottic secretion drainage (ETT-SD) and cuff pressure monitorization in VAP bundles have not been adequately assessed. In this study, we aimed to evaluate the effectiveness of VAP bundle containing ETT-SD and cuff pressure monitorization. This was a prospective, controlled study that was carried out between March 2011 and April 2012 including intubated patients. The study was conducted at the Anesthesiology Intensive Care Unit 1 and 2 (10 beds each) in a 898-bed university hospital. Occurrence of VAP and compliance with the parameters of the VAP...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator associated pneumonia; VAP prevention bundles; Subglottic secretion drainage; Cuff pressure monitorization.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300276

Assessment of the treatment of chronic hepatitis C virus infection: a case series from a hospital in the Brazilian Amazon region
Provedor de dados: 55
Autores: Amaral,Ivanete do Socorro Abraçado; Quaresma,Juarez Antonio Simões; Miranda,Esther Castello Branco de Mello; Móia,Lizomar de Jesus Maués Pereira; Soares,Manoel do Carmo Pereira.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200233

Associated risk factors and pulsed field gel electrophoresis of nasal isolates of Staphylococcus aureus from medical students in a tertiary hospital in Lagos, Nigeria
Provedor de dados: 55
Autores: Adesida,Solayide A.; Abioye,Olusegun A.; Bamiro,Babajide S.; Brai,Bartholomew I.C.; Smith,Stella I.; Amisu,Kehinde O.; Ehichioya,Deborah U.; Ogunsola,Folasade T.; Coker,Akitoye O.
Staphylococcus aureus infections are growing problems worldwide with important implications in hospitals. The organism is normally present in the nasal vestibule of about 35% of apparently healthy individuals and its carriage varies between different ethnic and age groups. Staphylococcal nasal carriage among health workers is particularly important to establish new clones and track origin of infections during outbreak situations. To determine the carriage rate and compare the pulsed field gel patterns of the strains, nasal swabs were collected from 185 medical students in a teaching hospital in Lagos, Nigeria. Isolates of S. aureus were tested for heamolysin production, methicillin sensitivity and Pulsed Field Gel Electrophoresis (PFGE) was performed. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; PFGE; Nasal isolates; Carriage rate.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100016

Association between age at diagnosis and degree of liver injury in hepatitis C
Provedor de dados: 55
Autores: Oliveira,Ana Cláudia de; Bortotti,Ana Clara; Nunes,Nathália Neves; Bacha,Ibrahin A.H. El; Parise,Edison Roberto.
Introduction:A population-based survey conducted in Brazilian capital cities found that only 16% of the population had ever been tested for hepatitis C. These data suggest that much of the Brazilian population with HCV infection remains undiagnosed. The distribution of age ranges at diagnosis and its association with the degree of hepatitis C are still unknown in Brazilian patients.Material and methods:Patients with HCV infection, diagnosed by HCV RNA (Amplicor-HCV, Roche), were included in the study. Patients with HBV or HIV coinfection, autoimmune diseases, or alcohol intake &gt; 20 g/day were excluded. HCV genotyping was performed by sequence analysis, and viral load by quantitative RT-PCR (Amplicor, Roche). The METAVIR classification was used to assess...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Age at diagnosis; Hepatic fibrosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500507

Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis
Provedor de dados: 55
Autores: Laurito,Marcela Pezzoto; Parise,Edison Roberto.
BACKGROUND/AIMS: Controversial results have been found in literature for the association between insulin resistance and sustained virologic response to standard chronic hepatitis C treatment. This study aims to provide a systematic literature review with meta-analysis, in order to evaluate if insulin resistance interferes with sustained virologic response in patients infected by the HCV genotype 1 versus HCV genotypes 2 and 3, undergoing treatment with interferon and ribavirin or pegylated interferon and ribavarin. METHODS: Systematic search was performed on main electronic databases until May 2012. Primary outcome was sustained virologic response, defined as undetectable levels of HCVRNA six months after the end of treatment. Meta-analytic measure was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Insulin resistance; Genotype; Sustained virologic response.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500008

Association between prostate cancer and schistosomiasis in young patients: a case report and literature review
Provedor de dados: 55
Autores: Bacelar,Albert; Castro,Larissa G.M.C.; Queiroz,Aristides Cheto de; Café,Eduardo.
This case report refers to a 47-year old patient with prostate cancer associated with schistosomiasis mansoni, who was submitted to radical prostatectomy. This is the third report published in the literature with respect to this association, and up to the present time it is still not known whether a cause and effect relationship exists between the two pathologies. The association between schistosomiasis and cancer has been well-documented in bladder cancer; however, there are no data yet proving the association of this disease with prostatic neoplasia. In this report, a third documented case of prostatic adenocarcinoma and schistosomiasis mansoni is described and a literature review is performed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prostate cancer; Schistosomiasis; Prostatectomy; Pathology.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500014

Association between the p53 arginine/arginine homozygous genotype at codon 72 and human papillomavirus E6/E7 mRNA expression
Provedor de dados: 55
Autores: Chuery,Ana Carolina Silva; Silva,Ismael Dale Cotrim Guerreiro da; Ribalta,Julisa Chamorro Lascasas; Speck,Neila Maria de Góis.
ABSTRACT  Objective: To evaluate the association between p53 polymorphisms and human papillomavirus (HPV) E6/E7 mRNA expression.  Methods: We analyzed 175 cervical samples from women aged 16-69 years old who were tested for HPV E6/E7 mRNA expression (NucliSENS® EasyQ® HPV). The samples were divided into three groups: positive (n = 75) those with positive HPV E6/E7 mRNA expression and positive high-risk HPV Hybrid Capture (HR-HC) test; negative (n = 52) those with negative HPV E6/E7 mRNA expression and positive HR-HC; and control (n = 48) those with negative HPV E6/E7 mRNA expression and negative HR-HC. The p53 polymorphisms at codons 11, 72, and 248 were evaluated through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human papillomavirus; Oncoproteins; Genetic polymorphisms; P53 gene; Arginine.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300248

Association between toll-like receptor2 Arg677Trp and 597T/C gene polymorphisms and pulmonary tuberculosis in Zahedan, Southeast Iran
Provedor de dados: 55
Autores: Naderi,Mohammad; Hashemi,Mohammad; Hazire-Yazdi,Leylisadat; Taheri,Mohsen; Moazeni-Roodi,Abdolkarim; Eskandari-Nasab,Ebrahim; Bahari,Gholamreza.
BACKGROUND: It is well known that toll-like receptor 2 (TLR2) mediates responses of both innate and adaptive immunity to microbial pathogen, including mycobacteria. Single-nucleotide polymorphisms (SNPs) in the TLR2 gene that impair its function may be associated with the development of pulmonary tuberculosis (PTB). The aim of this study was to evaluate the possible association between TLR2 Arg677Trp and 597T/C polymorphisms and PTB in a sample of Iranian population. MATERIALS AND METHODS: This case-;control study was performed on 174 PTB and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction (TARMS-PCR) was used to detect the SNPs. RESULTS: There was no significant difference in the polymorphism of Arg677Trp of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; TLR2; Single nucleotide polymorphism.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500002

Association between vitamin B12 level and anti-parietal cells and anti-intrinsic factor antibodies among adult Jordanian patients with Helicobacter pylori infection
Provedor de dados: 55
Autores: Ayesh,Mahmoud H.; Jadalah,Khaled; Awadi,Eiman Al; Alawneh,Khaldoon; Khassawneh,Basheer.
OBJECTIVE: Evaluate the association of Helicobacter pylori infection with anti-parietal cell antibodies (APCA) and anti-intrinsic factor antibodies (AIFA) and their impact on vitamin B12 serum level. PATIENTS AND METHODS: One hundred patients (M/F: 43/57; age 46.5 ± 17.5 years) who underwent upper gastrointestinal endoscopy at King Abdullah University Hospital, Irbid, Jordan were enrolled in the study. The patients were grouped as H. pylori-infected (n = 81) or H. pylori negative (n = 19) by histopathological examination. Fasting serum vitamin B12 levels, antiparietal cell antibodies and anti-intrinsic factor antibodies for patients and controls were determined. RESULTS: Anti-parietal cell antibodies and anti-intrinsic factor antibodies were positive in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vitamin B12; Anti-parietal cell antibodies; Anti-intrinsic factor antibodies; H. pyloriby.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600001

Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case–control study
Provedor de dados: 55
Autores: Thamizhmani,Ramanathan; Vijayachari,Paluru.
Oligoadenylate synthetases play an important role in the immune response against dengue virus. Single nucleotide polymorphisms in the oligoadenylate synthetases genes are known to affect oligoadenylate synthetases activity and are associated with outcome of viral infections. Polymorphisms in the OAS1 SNPs (rs1131454), OAS2 SNPs (rs1293762, rs15895 and rs1732778) and OAS3 SNPs (rs2285932 and rs2072136) genes were studied using PCR followed by restriction fragment length polymorphism methods in 30 patients for dengue infection and 40 control group who have no documented evidence of symptomatic dengue. An increase in the frequency of OAS2 gene rs1293762 SNP G/T heterozygotes (p = 0.012), decrease in the frequency of SNP G/G homozygotes (p = 0.005) and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue; 2'-5'-Oligoadenylate synthetase; Polymorphisms; Genotypes.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500548

Association of genetic polymorphisms of CISH with the risk of pulmonary tuberculosis in Zahedan, Southeast Iran
Provedor de dados: 55
Autores: Naderi,Mohammad; Hashemi,Mohammad; Safdari,Abolhassan; Bahari,Gholamreza; Taheri,Mohsen.
Abstract  Background In the current study we aimed to find out the impact of cytokine-inducible Src homology 2 domain protein (CISH) gene polymorphisms on the risk of pulmonary tuberculosis (PTB) in a sample of Iranian population.  Materials and methods Polymorphisms of CISH rs2239751, rs414171, and rs6768300 were determined in 200 PTB patients and 200 healthy subjects using T-ARMS-PCR or PCR-RFLP method.  Results The results showed that rs414171 A&gt;T genotypes significantly decreased the risk of PTB (OR = 0.16, 95% CI = 0.10–0.27, p &lt; 0.0001, AT vs AA; OR = 0.31, 95% CI = 0.14–0.68, p &lt; 0.0001, TT vs AA; OR = 0.19, 95% CI = 0.12–0.29, p &lt; 0.0001, AT+TT vs AA; OR = 0.29, 95%CI = 0.20–0.42, p &lt; 0.0001, T vs A). For rs6768300, the findings...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; CISH; Polymorphism.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400379

Association of HTLV-I with Arnold Chiari syndrome and syringomyelia
Provedor de dados: 55
Autores: Viana,Graça Maria de Castro; Diniz Neto,João Arnaud; Furtado,Igor de Sousa; Binda Júnior,José Roberto; Tanaka,Bárbara Neiva; Nascimento,Maria do Desterro Soares Brandão.
HTLV-I is associated with a broad spectrum of manifestations, including tropical spastic paraparesis and adult T-cell leukemia/lymphoma. Arnold Chiari syndrome is a condition characterized by herniation of the cerebellar tonsils through the foramen magnum. This condition should be suspected in all patients with headache and impaired motor coordination. Syringomyelia is a developmental anomaly that leads to the formation of an intramedullary cavity. Its clinical presentation is classically characterized by syringomyelic dissociation of sensation, with suspended distribution in the proximal portion of the trunk and upper limbs and preservation in other regions. We report here a case of association of the three diseases, which is rare in clinical practice,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-I; Arnold Chiari syndrome; Syringomyelia.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600018

Association of IL-8-inducing strains of diffusely adherent Escherichia coli with sporadic diarrheal patients with less than 5 years of age
Provedor de dados: 55
Autores: Meraz,Ismail Mustafa; Arikawa,Kentaro; Nakamura,Hiromi; Ogasawara,Jun; Hase,Atsushi; Nishikawa,Yoshikazu.
The role of diffusely adherent Escherichia coli (DAEC) in diarrheal disease has been controversial. However, DAEC strains were recently implicated in diarrheal disease in developing countries. To clarify whether DAEC are prevalent among sporadic cases of diarrheal illness in Osaka City, Japan, E. coli strains isolated between July 1997 and March 2000 during diarrheagenic E. coli (DEC) investigation were retrospectively examined. DAEC strains were recognized among 41 (4.4%) of 924 patients and formed the biggest subgroup of DEC. Previously, we reported that some DAEC strains caused epithelial cells to secrete as much IL-8 as enteroaggregative E. coli strains did. In this study, we attempted to evaluate epidemiologically whether the ability of DAEC to induce...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DAEC; IL-8; Afa; Age; Epidemiology.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100012

Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population
Provedor de dados: 55
Autores: Yuan,Jun; Zhang,Yan; Yan,Fu-tang; Zheng,Xiao.
ABSTRACT  Objective: Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study.  Methods: We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested.  Results: Rs1002424 polymorphism showed significant difference in the allele frequencies, but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; PRKAA1 gene; SNP; Association study.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600564

Association of X4 tropism with disease progression in antiretroviral-treated children and adolescents living with HIV/AIDS in São Paulo, Brazil
Provedor de dados: 55
Autores: Almeida,Flávia Jacqueline; Zaparoli,Mayra Simioni; Moreira,Denise Helena; Cavalcanti,Jaqueline de Souza; Rodrigues,Rosangela; Berezin,Eitan Naaman; Ferreira,João Leandro de Paula; Sáfadi,Marco Aurélio Palazzi; Brígido,Luis Fernando de Macedo.
Management of children with HIV/AIDS is specially challenging. Age-related issues do not allow for direct transposition of adult observations to this population. CXCR4 tropism has been associated with disease progression in adults. The geno2pheno web-base is a friendly tool to predict viral tropism on envelope V3 sequences, generating a false positive rate for a CXCR4 prediction. We evaluated the association of HIV-1 tropism prediction with clinical and laboratory outcome of 73 children with HIV/AIDS in São Paulo, Brazil. The CXCR4 tropism was strongly associated with a lower (nadir) CD4 documented during follow-up (p &lt; 0.0001) and with disease severity (clinical event and/or CD4 below 200 cells/mm3) at the last observation, using commonly applied...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Children; Viral tropism; Disease progression.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300300

Asthma exacerbation and viral infection in adult patients, Brazil
Provedor de dados: 55
Autores: Silva,Raquel Cirlene; Couceiro,José Nelson; Câmara,Fernando Portela; Valle,Solange; Santos,Norma.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400446

Asymetric testicular schistosomal infection
Provedor de dados: 55
Autores: Athanazio,Daniel Abensur; Athanazio,Paulo Roberto Fontes.
Tipo: Info:eu-repo/semantics/article
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600001

Asymptomatic and symptomatic embolic events in infective endocarditis: associated factors and clinical impact
Provedor de dados: 55
Autores: Monteiro,Thaíssa S.; Correia,Marcelo G.; Golebiovski,Wilma F.; Barbosa,Giovanna Ianini F.; Weksler,Clara; Lamas,Cristiane C.
ABSTRACT  Background: Embolic complications of infective endocarditis are common. The impact of asymptomatic embolism is uncertain.  Objectives: To determine the frequency of emboli due to IE and to identify events associated with embolism.  Methods: Retrospective analysis of an endocarditis database, prospectively implemented, with a post hoc study driven by analysis of data on embolic events. Data was obtained from the International Collaboration Endocarditis case report forms and additional information on embolic events and imaging reports were obtained from the medical records. Variables associated with embolism were analyzed by the statistical software R version 3.1.0.  Results: In the study period, 2006-2011, 136 episodes of definite infective...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infective endocarditis; Embolism; Asymptomatic embolism; Splenomegaly; Cardiac surgery; Splenectomy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300240

At the crossroads between early or delayed antiretroviral therapy initiation during tuberculosis/human immunodeficiency virus coinfection
Provedor de dados: 55
Autores: Moreira,José Alfredo de Sousa.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500576

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru
Provedor de dados: 55
Autores: Llanos-Cuentas,A.; Campos,P.; Clendenes,M.; Canfield,C. J.; Hutchinson,D. B. A.
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients were initially randomized to receive 1,000 mg atovaquone and 400 mg proguanil hydrochloride daily for 3 days (n=15) or 1,500 mg chloroquine (base) over a 3 day period (n=14) (phase 1). The cure rate with chloroquine was lower than expected and patients were subsequently randomized to receive a single dose of 75 mg pyrimethamine and 1,500 mg sulfadoxine (n=9) or atovaquone/proguanil as before (n=5) (phase 2). In phase 1, atovaquone/proguanil was significantly more effective than chloroquine (cure rate 100% [14/14] versus 8%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malarone; Atovaquone; Proguanil; Chloroquine resistance; Peru.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200004

Atypical case of Mediterranean spotted fever
Provedor de dados: 55
Autores: Figueira-Coelho,João; Martins,Teresa; Machado,João; Maltez,Fernando.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300001

Atypical cutaneous mycobacteriosis caused by Mycobacterium avium complex
Provedor de dados: 55
Autores: Ferreira,Cassio Porto; Coutinho,Ziadir Francisco; Lourenço,Maria Cristina; Rocha,Adalgiza da Silva; Martins,Carlos José.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300024

Atypical duodenal mycobacteriosis in a patient with AIDS
Provedor de dados: 55
Autores: Aldeman,Nayze Lucena Sangreman; Guimarães,Lize Maciel; Cabral,Monica Maria Demas Alvares.
Tipo: Info:eu-repo/semantics/report
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200020

Atypical fulminant Rickettsia rickettsii infection (Brazilian spotted fever) presenting as septic shock and Adult Respiratory Distress Syndrome
Provedor de dados: 55
Autores: Costa,Paulo Sérgio Gonçalves da; Brigatte,Marcos Emilio; Almeida,Edmilton Pereira de; Valle,Lena Márcia de Carvalho.
Brazilian spotted fever, caused by Rickettsia rickettsii, has been increasingly reported in Brazil especially in the southeastern states. The severe and fulminant forms of the disease are not unusual but most of the reported fatal cases have shown some typical clinical clue, which leads the attending physician to a correct diagnosis. We report a probable case of atypical fulminant Brazilian spotted fever that presented full-blown septic shock associated with Adult Respiratory Distress Syndrome (ARDS) and delayed uncharacteristic rash with an over four-fold increase in reciprocal IgM, but not IgG titer against Rickettsia rickettsii. Brazilian practitioners should be aware of the possibility of Brazilian spotted fever as a cause of fulminant primary sepsis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rickettsia rickettsii; Brazilian spotted fever; Sepsis; ARDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200006

Atypical presentation of syphilis in an HTLV-I infected patient
Provedor de dados: 55
Autores: Carnaúba Jr,Dimas; Bittencourt,Achiléa; Brites,Carlos.
We report the case of a 44 year-old female, who presented a long-lasting, clinically atypical, secondary syphilis ("malignant syphilis") in the right foot, which started six months before medical evaluation. The patient had a serological diagnosis of HTLV-I infection and syphilis two years before the onset of the skin lesions, following a blood donation. As she believed she was allergic to penicillin, she initially received sulfamethoxazole + trimethoprim, without any improvement of the clinical picture. After failure of this first treatment regimen, she was given penicillin, which promoted complete healing of the lesion. We found evidence that infection by HTLV-I is capable of modifying the clinical course of secondary syphilis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Secondary syphilis; HTLV-I infection; Syphilis/HTLV-I coinfection; Malignant syphilis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400008

Audiological and electrophysiological evaluation of children with acquired immunodeficiency syndrome (AIDS)
Provedor de dados: 55
Autores: Matas,Carla Gentile; Leite,Renata Aparecida; Magliaro,Fernanda Cristina Leite; Gonçalves,Isabela Crivellaro.
We examined the peripheral auditory system and the auditory brainstem pathway of children with Acquired Immunodeficiency Syndrome (AIDS). One hundred and one children, 51 with AIDS diagnosis and 50 normal children were evaluated. Audiological assessment included immittance measures, pure tone and speech audiometry and auditory brainstem response (ABR). The children with AIDS more frequently had abnormal results than did their matched controls, presenting either peripheral or auditory brainstem impairment. We suggest that AIDS be considered a risk factor for peripheral and/or auditory brainstem disorders. Further research should be carried out to investigate the auditory effects of HIV infection along the auditory pathway.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; Hearing; Auditory Brainstem Response (ABR); HIV.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400010

Audit of antibiotic use in a Brazilian University Hospital
Provedor de dados: 55
Autores: Fonseca,Laura Guimarães; Conterno,Lucieni de Oliveira.
A cohort study was carried out at the Marilia Medical School Hospital. In the first phase the pattern of antibiotic use was evaluated. Antibiotics were prescribed for 55.4% of the patients; antibiotic combinations were used in 43%. Therapeutic use of antibiotics was considered inadequate in 27%. Respiratory and skin infections were the most frequently diagnosed. In up to 31% of the cases the treatment of respiratory infections was considered inadequate. The surgical use of antibiotic prophylaxis was evaluated in the second phase. Prophylaxis was indicated in 73.2% of the surgeries. The antibiotics most used for prophylaxis were first generation cephalosporins. In 78.9% of the surgeries, the antibiotic was correctly chosen. In 15.9% of the surgeries, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotic use; Evaluation; Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400002

Auditory disorders and acquisition of the ability to localize sound in children born to HIV-positive mothers
Provedor de dados: 55
Autores: Matas,Carla Gentile; Iorio,Maria Cecília Martinelli; Succi,Regina Célia de M.
The objective of the present study was to evaluate children born to HIV-infected mothers and to determine whether such children present auditory disorders or poor acquisition of the ability to localize sound. The population studied included 143 children (82 males and 61 females), ranging in age from one month to 30 months. The children were divided into three groups according to the classification system devised in 1994 by the Centers for Disease Control and Prevention: infected; seroreverted; and exposed. The children were then submitted to audiological evaluation, including behavioral audiometry, visual reinforcement audiometry and measurement of acoustic immittance. Statistical analysis showed that the incidence of auditory disorders was significantly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Audiological evaluation; HIV-positive mothers; Children.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100004

Austrian syndrome in the context of a fulminant pneumococcal native valve endocarditis
Provedor de dados: 55
Autores: Wilbring,Manuel; Tugtekin,Sems-Malte; Matschke,Klaus; Kappert,Utz.
This is the case of a young male suffering from Austrian syndrome, which is the triad of endocarditis, meningitis, and pneumonia due to invasive S. pneumoniae infection. He reported recurrent fever for six months without any antibiotic treatment, which may have determined the further course of the syndrome. Echocardiography revealed massive native valve endocarditis, and the patient was considered for ultima-ratio cardiac surgery. Intraoperative aspect presented extensive affection of the aortic root with full destruction of aortic valve, mitral valve, and aortomitral continuity. The myocardium showed a phlegmonlike infiltration. Microbiologic testing of intraoperatively collected specimens identified penicillin-sensitive Streptococcus pneumoniae. S....
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Streptococcus pneumonia; Endocarditis; Austrian syndrome.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500016

Autoimmune and dengue fever
Provedor de dados: 55
Autores: Wiwanitkit,Viroj.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500020

Autoimmune features caused by dengue fever: a case report
Provedor de dados: 55
Autores: Jardim,Denis Leonardo Fontes; Tsukumo,Daniela Miti Lemos; Angerami,Rodrigo N.; Carvalho Filho,Marco Antonio de; Saad,Mário José Abdalla.
Dengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. Herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features. Our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. She had a low C3 level and positive antinuclear antibody; cryoglobulins were also positive. The numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. Dengue...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue; Autoimmunity; Hematologic diseases.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100018

Autologous hematopoetic stem cell transplantation for HIV-related Non-Hodgkin's Lymphomas (NHL)
Provedor de dados: 55
Autores: Bittencourt,Henrique.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500026

Autologous transplant: microbial contamination of hematopoietic stem cell products
Provedor de dados: 55
Autores: Almeida,Igor Dullius; Schmalfuss,Tissiana; Röhsig,Liane Marise; Goldani,Luciano Zubaran.
Hematopoietic progenitor cells from peripheral blood (HPCPB) are commonly used for autologous and allogenic transplants in patients with most various onco-hematological diseases, and despite the utilization of sterile techniques during collection and processing of these products, bacterial contamination can occur. This study aimed to investigate the microbial contamination of HPCPB products. Microbial cultures of 837 HPCPB products between the year 2000 and 2009 were retrospectively analyzed to determine the incidence of culture positivity and identify the main organisms that cause contamination. The microbiological studies were performed with an automated system (BacT/Alert® bioMérieux Corporate). Thirty-six (4.3%) of 837 microbial cultures were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Autologous transplant; Hematopoietic stem cell products; Microbial contamination; Quality control; Bacterial contamination.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400006

Avascular necrosis of the femoral head in HIV infected patients
Provedor de dados: 55
Autores: Matos,Marcos Almeida; Alencar,Rafael Watt de; Matos,Simone Souza da Rocha.
Avascular necrosis (AVN) of the femoral head is an emerging complication in HIV infected patients. It has been suggested that the increased incidence of AVN in this population may be caused by an increased prevalence of predisposing factors for osteonecrosis, including protease inhibitors, hyperlipidemia, corticosteroid use, alcohol and intravenous drug abuse. The aim of this study was to assess the risk factors for avascular necrosis developing in the femoral head of HIV infected individuals. This study consisted of meta-analysis of the secondary data extracted from current literature. The selected articles allowed two study groups to be drawn up for comparison. Group 1 comprised 324 individuals infected by the HIV virus, who did not present femoral head...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; Avascular necrosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100009

Avidity of IgG for rubella: an evaluation of the need for implementation at the Materno-Infantil Presidente Vargas Hospital in Porto Alegre, Rio Grande do Sul, Brazil
Provedor de dados: 55
Autores: Reis,M.M.; Tessaro,M.M.; Cruz e Silva,J.; Giordano,S. A.; d'Azevedo,P.A.
Rubella serum assays performed in the laboratory of the Materno-Infantil Presidente Vargas Hospital (HMIPV) from 1998 to 2002 were reviewed to determine if IgG avidity assays should be implemented. IgG was determined using the Enzyme Linked Fluorescent Assay, ELFA, VIDAS® system, bioMérieux or the Microparticle Enzyme Immunoassay, MEIA, Axsym® system, Abbott, and IgM was determined using the ELFA, VIDAS® system, bioMérieux, a capture format assay. Specific IgG was assayed in 2,863 samples, with positive results for 84% of the patients, for the most part with high levels of antibodies. IgM was assayed in 2,851 samples, being positive in 14 (0.49%) and inconclusive in 25 (0.88%). Serology for toxoplasmosis was also positive or inconclusive in 5 patients....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rubella virus infection; Congenital infection; Avidity of IgG for rubella; Serology for rubella virus.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300009

Bacteremia among liver and kidney transplant recipients: etiologic agents and antimicrobial susceptibilities
Provedor de dados: 55
Autores: Serefhanoglu,Kivanc; Timurkaynak,Funda; Arslan,Hande; Karakayali,Hamdi.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400023

Bacteremia due to Achromobacter xylosoxidans in neonates: clinical features and outcome
Provedor de dados: 55
Autores: Turel,Ozden; Kavuncuoglu,Sultan; Hosaf,Emine; Ozbek,Sibel; Aldemir,Esin; Uygur,Turkan; Hatipoglu,Nevin; Siraneci,Rengin.
OBJECTIVE: We report an outbreak of Achromobacter xylosoxidans at a neonatal intensive care unit. We aimed to present clinical, laboratory and treatment data of the patients. Materials and METHODS: All consecutive episodes of bacteremia due to A. xylosoxidans at our neonatal intensive care unit, beginning with the index case detected at November 2009 until cessation of the outbreak in April 2010, were evaluated retrospectively. RESULTS: Thirty-four episodes of bacteremia occurred in 22 neonates during a 6-month period. Among the affected, 90% were preterm newborns with gestational age of 32 weeks or less and 60% had birth weight of 1000 g or less. Endotracheal intubation, intravenous catheter use, total parenteral nutrition and prolonged antibiotic therapy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Achromobacter xylosoxidans; Bloodstream infection; Neonate.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400011

Bacteremia due to Moraxella osloensis: a case report and literature review
Provedor de dados: 55
Autores: Maruyama,Yuta; Shigemura,Tomonari; Aoyama,Koki; Nagano,Noriyuki; Nakazawa,Yozo.
ABSTRACT Herein we report the case of a 10-year-old boy with an autosomal mosaic mutation who developed bacteremia. The causative agent was identified as Moraxella osloensis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. In the pediatric population, there have been 13 case reports of infection attributed to M. osloensis and this is the fifth reported case of pediatric bacteremia due to M. osloensis. After Moraxella species infection was confirmed, the patient recovered with appropriate antimicrobial therapy. It is important to consider that M. osloensis can cause serious infections, such as bacteremia, in otherwise healthy children.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Moraxella osloensis; Bacteremia; MALDI-TOF MS; 16S rRNA gene sequencing.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100060

Bacteremic pneumococcal pneumonia: serotype distribution, antimicrobial susceptibility, severity scores, risk factors, and mortality in a single center in Chile
Provedor de dados: 55
Autores: Fica,Alberto; Bunster,Nicolás; Aliaga,Felipe; Olivares,Felipe; Porte,Lorena; Braun,Stephanie; Dabanch,Jeannette; Hormázabal,Juan Carlos; Hernández,Antonio; Benavides,María Guacolda.
AIMS:Bacteremic pneumococcal pneumonia (BPP) is a severe condition. To evaluate seasonal distribution, mortality, serotype frequencies, antimicrobial susceptibility, and different severity scores among patients with BPP.PATIENTS AND METHODS:Patients were identified by laboratory data and restricted to adulthood. Standard methods were used for serotyping and antimicrobial susceptibility. Risk factors were analyzed by univariate and multivariate methods. Severity scores (APACHE II, CURB-65 and CAP PIRO) were compared using ROC curves.RESULTS:Sixty events of community-acquired BPP occurred between 2005 and 2010. A seasonal pattern was detected. Mean age was 72.1 years old (81.4% &gt;60 years). All had a predisposing factor. Previous influenza (3.3%) or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Bacteremia; Serotyping; Microbial drug resistance; Risk factors; Mortality; Elderly; CURB-65; APACHE II; PIRO.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200115

Bacterial biofilm in chronic venous ulcer
Provedor de dados: 55
Autores: Honorato-Sampaio,Kinulpe; Guedes,Antonio Carlos Martins; Lima,Vera Lúcia de Araújo Nogueira; Borges,Eline Lima.
Tipo: Info:eu-repo/semantics/article
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300350

Bacterial contamination in milk kitchens in pediatric hospitals in Salvador, Brazil
Provedor de dados: 55
Autores: Cairo,Romilda Castro; Silva,Luciana Rodrigues; Andrade,Carol Ferreira de; Barberino,Maria Goreth de Andrade; Bandeira,Antônio Carlos; Santos,Kleber Pimentel; Diniz-Santos,Daniel R.
Milk may represent an important source of infectious agents to hospitalized pediatric patients. To describe the bacterial microflora isolated from the hands, stools, pharynx of all workers at milk kitchens in pediatric hospitals in the city of Salvador, Brazil, as well as in the formulas prepared by them, we carried out this cross-sectional study with all 91 workers from the 20 milk kitchens of all the public and private hospitals in Salvador, Brazil. Hand and pharynx swabs and stool samples were collected from all workers, as well as samples of the milk and formulas delivered by the kitchens. All samples were cultured for the detection of pathogenic and non-pathogenic bacteria. Pathogenic bacteria were isolated from 20 (22.0%) and 8 (8.8%) cultures of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteria; Microflora; Hands; Faeces; Pharynx; Milk; Contamination; Hospital; Children.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300011

Bacterial sensitivity to fosfomycin in pregnant women with urinary infection
Provedor de dados: 55
Autores: Souza,Rodrigo Batista; Trevisol,Daisson José; Schuelter-Trevisol,Fabiana.
The aim this study was to determine the in vitrosusceptibility to fosfomycin of bacteria isolated from urine samples of pregnant women with urinary tract infection. Samples of urine culture with bacterial growth of pregnant women were collected from clinical laboratories in Tubarão, state of Santa Catarina, Brazil, between September 2012 and May 2013. In the experimental stage, the colonies were tested for sensitivity to fosfomycin by using the Kirby-Bauer method. The following information relating to the samples was also collected: patients' age, colony count, type(s) of identified bacterial(s) and result of the antimicrobial sensitivity test. Student's t-test was used for mean comparison. A total of 134 samples were selected for the study. The age of the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Fosfomycin Pregnancy Urinary tract; Microbial sensitivity tests.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300319

Bacteroides fragilis endocarditis: a case report and review of literature
Provedor de dados: 55
Autores: Rodrigues,Cristhieni; Siciliano,Rinaldo Focaccia; Zeigler,Rogerio; Strabelli,Tania Mara Varejão.
Endocarditis due to Bacteroides fragilis is a rare disorder. This article describes a case of Bacteroides fragilis endocarditis associated with portal and superior mesenteric venous thrombosis in a patient without preexisting valvular heart disease and review the cases of endocarditis due to this anaerobic bacterium in medical literature since 1980.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Endocarditis; Bacteroides fragilis; Gram-negative anaerobic bacteria.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100020

Barriers to treatment of hepatitis C in HIV/HCV coinfected adults in Brazil
Provedor de dados: 55
Autores: Mendes-Corrêa,Maria Cássia; Martins,LG; Ferreira,PA; Tenore,S; Leite,OH; Leite,AG; Cavalcante,AJW; Shimose,M; Silva,MH; Uip,DE; Abrão Ferreira,PR.
The objective of this study was to assess the prevalence of barriers to interferon treatment in a population of HIV/HCV coinfected patients. A cross-sectional study was conducted at two AIDS Outpatient Clinics in Brazil. The study included all HIV infected patients followed at these institutions from January 2005 to November 2007. Medical records of 2,024 HIV-infected patients were evaluated. The prevalence of anti-HCV positive patients among them was 16.7%. Medical records of HCV/HIV coinfected patients were analyzed. 189 patients with the following characteristics were included in our study: mean age 43 years; male gender 65%; former IDUs (52%); HCV genotype 1 (66.4%); HCV genotype 3 (30.5%); median CD4+ T cell count was 340 cells/mm³. Among 189 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; HIV; Coinfected; Treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300007

Bartonella native valve endocarditis: the first brazilian case alive and well
Provedor de dados: 55
Autores: Lamas,C.; Favacho,A.; Ramos,R.G.; Santos,M.S.; Ferravoli,G.I.; Weksler,C.; Rozental,T.; Bóia,M.N.; Lemos,E.R.S.
Bartonella is an important cause of blood culture-negative endocarditis in recent studies. Seroprevalence studies in the States of Minas Gerais and Rio de Janeiro have shown Bartonella IgG positivity around 14% in healthy adults and 40% in HIV seropositive adults, respectively. A case report of a 46-year-old white male with moderate aortic regurgitation (AR) due to rheumatic heart disease (RHD), admitted due to worsening heart failure, is presented. Clinical features were apyrexia, anemia, polyclonal hypergammaglobulinemia, hematuria and splenomegaly. He was submitted to surgery due to worsening AR. Histopathology of the excised valve showed active bacterial endocarditis and underlying RHD. Routine blood cultures were negative. Indirect immunofluorescence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bartonella spp.; Infective endocarditis; Blood culture-negative infective endocarditis; Rheumatic heart disease; Serology; Indirect immunofluorescence.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600012

Bartonella species pathogenic for humans infect pets, free-ranging wild mammals and their ectoparasites in the Caatinga biome, Northeastern Brazil: a serological and molecular study
Provedor de dados: 55
Autores: Fontalvo,Mariana Campos; Favacho,Alexsandra Rodrigues de Mendonça; Araujo,Andreina de Carvalho; Santos,Naylla Mayana dos; Oliveira,Glauber Meneses Barboza de; Aguiar,Daniel Moura; Lemos,Elba Regina Sampaio de; Horta,Mauricio Claudio.
ABSTRACT This study verified the occurrence of Bartonella spp. in dogs, cats, wild mammals and their ectoparasites in Petrolina and Lagoa Grande Counties, Pernambuco, located in a semi-arid region in Northeastern Brazil. Anti-Bartonella spp. antibodies were detected by indirect immunofluorescence assay (IFA) in 24.8% of dogs (27/109) and in 15% of cats (6/40). Bartonella sp. DNA was identified by PCR performed on DNA extracted from blood and ectoparasites using primers targeting Bartonella sp. gltA and ribC genes in 100% (9/9) of Pulex irritans from Cerdocyon thous, 57.4% (35/61) of P. irritans from dogs, 2.3% (1/43) of Ctenocephalides felis felis from dogs, 53.3% (24/45) of C. felis felis from cats, and 10% (1/10) of Polyplax spp. from Thrichomys...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bartonella; Flea; Tick; Lice; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300290

Bartonellosis diagnosis requires careful evaluation
Provedor de dados: 55
Autores: Drummond,Marina Rovani; Gilioli,Rovilson; Velho,Paulo Eduardo Neves Ferreira.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300002

Bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues
Provedor de dados: 55
Autores: Manfredi,Roberto; Sabbatani,Sergio.
Cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. Two suggestive episodes of Bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. The first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. Both episodes were characterized by a very prolonged and complicated disease course (with the involvement of three lymph node sets in the first case), a need for lymph-node drainage, and apparently negligible activity of many antimicrobial courses, with a very slow local cure. While specific culture and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adults; Antimicrobial chemotherapy; Bartonellosis; Bartonella henselae; Case reports; Children; Clinical presentation; Outcome; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600012

Bartonelosis (Carrion's Disease) in the pediatric population of Peru: an overview and update
Provedor de dados: 55
Autores: Huarcaya,Erick; Maguiña,Ciro; Torres,Rita; Rupay,Joan; Fuentes,Luis.
Bartonellosis, or Carrion's Disease, is an endemic and reemerging disease in Peru and Ecuador. Carrion's Disease constitutes a health problem in Peru because its epidemiology has been changing, and it is affecting new areas between the highland and the jungle. During the latest outbreaks, and previously in endemic areas, the pediatric population has been the most commonly affected. In the pediatric population, the acute phase symptoms are fever, anorexia, malaise, nausea and/or vomiting. The main signs are pallor, hepatomegaly, lymphadenopathies, cardiac murmur, and jaundice. Arthralgias and weight loss have also commonly been described. The morbidity and mortality of the acute phase is variable, and it is due mainly to superimposed infections or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bartonellosis; Carrion's disease.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500001

Basic aspects of the treatment for hepatitis C: mechanisms of action of interferon alpha and ribavirin and the bases of individualization
Provedor de dados: 55
Autores: Melo,Carlos Eduardo de; Araújo,Evaldo Stanislau Affonso de; Barone,Antonio Alci.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700014

Basic guidelines for the treatment of HIV/HVC co-infection
Provedor de dados: 55
Autores: Bortholi,Edgard De.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700013

BCGiosis as a presenting feature of a child with chronic granulomatous disease
Provedor de dados: 55
Autores: Movahedi,Zahra; Norouzi,Sayna; Mamishi,Setareh; Rezaei,Nima.
Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: BCG vaccine; Mycobacterium bovis; Granulomatous disease; Chronic.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100016

Bedbugs (Cimicidae infestation): the worldwide renaissance of an old partner of human kind
Provedor de dados: 55
Autores: Criado,Paulo Ricardo; Belda Junior,Walter; Criado,Roberta Fachini Jardim; Silva,Roberta Vasconcelos e; Vasconcellos,Cidia.
Bedbugs have been known as a human parasite for thousands of years, but scientific studies about this insect are recent and limited. Cimex lectularius, the common bedbug, was a well-known parasite in human dwellings until the end of the Second World War. Nowadays, bedbugs are considered uncommon in the industrialized world. Anecdotal reports suggest that bedbugs are getting more common in the United States, Canada, and United Kingdom. In Brazil, there are few reports about bedbug infestations in the literature. The aim of this article was to alert physicians, especially in Brazil, about this ectoparasitosis, including aspects of the bedbug biology, their parasitism in human host, treatment and prophylaxis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemiptera; Bedbugs; Cimex lectularius; Pyrethrins; DDT.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100014

Behavioral and biological risks of women seeking HIV test in an anonymous testing center
Provedor de dados: 55
Autores: Ribeiro Filho,Ayrton Daniel; Giraldo,Paulo César; Silva,Maria José Penna Maisonnette de Attayde; Amaral,Rose Luce Gomes do; Eleutério Junior,José; Gonçalves,Ana Katherine da Silveira.
Due to the high prevalence and morbidity sexually transmitted diseases are highly relevant to public health, especially for women. OBJECTIVES: To determine and compare the behavioral and biological risks associated with human immunodeficiency virus acquisition. METHODS: A group of 253 women who voluntarily sought anonymous testing were interviewed to find out their behavioral risk. Biological risk was identified by means of gynecological exam, colposcopy as well as blood and cervicovaginal sampling for serological and microbiological exams. Using known traditional risk factors, a table of scores classified the subjects into high, low and absent for behavioral and biological risks. Frequency and percentage of each risk was tabulated and the correlation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Sexually transmitted diseases; Women.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400010

beta-lactamase production Haemophilus spp. and resistance to ampicillin in a general hospital in Porto Alegre city, RS, Brazil (2001-2005)
Provedor de dados: 55
Autores: Ferreira,Jorge A. S.; Castro,Andréa Cauduro de; Rocha,Marion P.; Riboldi,Gustavo; d'Azevedo,Pedro Alves.
In a four-year period (July/2001-June/2005), 410 Haemophilus spp. isolates were studied. Those were isolated from sputum at Hospital Nossa Senhora da Conceição (NSC) in Porto Alegre city (RS). beta-lactamase enzyme was detected in 113 (27.6%) of isolates through chromogenic cephalosporin method. Fifty-eight (51.3%) of them showed sensibility to ampicillin through disc-diffusion method using Haemophilus Test Medium (HTM) by NCCLS criteria. In 297 (72.4%) isolates beta-lactamase was not detected by chromogenic cephalosporin method. Five (1.7%) of them were resistant and 1 (0.3%) intermediate to ampicillin using disc-diffusion method. The authors emphasized the importance of Haemophilus spp. resistance to ampicillin research in clinical laboratories routine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haemophilus spp.; Beta-lactamase; Antimicrobial resistance; Ampicillin.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100013

Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly active antiretroviral therapy
Provedor de dados: 55
Autores: Geraix,Juliana; Souza,Micheli Evangelista de; Delatim,Francieli Cristina; Pereira,Paulo Câmara Marques.
The use of highly active antiretroviral therapy (HAART) in HIV-infected patients has been associated with the development of risk factors for cardiovascular diseases (CD) including dyslipidemia and insulin resistance, hypertriglyceridemia being the most frequent metabolic disturbance in these patients. Fibrates are indicated when hypertriglyceridemia is accentuated and persists for over six months. We evaluated the efficacy and safety of bezafibrate for the treatment of hypertriglyceridemia in HIV-infected individuals on HAART. All patients received 400mg/day of bezafibrate and were evaluated three times: Mo (pre-treatment), M1 (one month after treatment), and M2 (six months after treatment). Fifteen adult individuals, eight males and seven females with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HAART; Hypertriglyceridemia; Bezafibrate.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300001

Bilateral afrenal nodules due to histoplasmosis in an elderly
Provedor de dados: 55
Autores: Carvalho,Flávio Pedreira de Freitas de; Curiati,José Antônio Esper; Mauad,Thaís; Incerti,Milena Mendes; Jacob Filho,Wilson.
We report a case history of an 84-year-old elderly male patient that presented with a clinical picture suggestive of adrenal failure and bilateral adrenal nodules detected by abdominal computed tomography. A fine needle-guided biopsy was inconclusive for achieving a final diagnosis. The patient died due to septic shock and the autopsy disclosed histoplasmosis with extensive bilateral necrosis of the adrenal glands. Although the adrenal involvement in chronic disseminated histoplasmosis has been described, there have been few reports of the infection being associated with adrenal insufficiency.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Histoplasmosis; Adrenal nodule; Addison disease; Elderly; Histoplasma capsulatum.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100033

Bilateral endogenous endophthalmitis associated with infective endocarditis: case report
Provedor de dados: 55
Autores: Arcieri,Enyr Saran; Jorge,Eduardo Ferreira; Ferreira,Lizane de Abreu; Fonseca,Maria B. da; Ferreira,Magno Antônio; Arcieri,Rafael Saran; Rocha,Flávio Jaime.
Bilateral endogenous endophthalmitis is a rare condition initiated by infection by microbes in the bloodstream, such as those arising from a foci of infective endocarditis. We report a case and discuss the diagnostic aspects and the clinical outcome of a patient with characteristic findings of the disease. The patient was a 49 year old white male who had a metallic aortic valve implanted 7 months previously, and who presented to the hospital with 10 days of fever, cough and dyspnea, then diarrhea and mental confusion. On the second day of hospitalization, he experienced sudden loss of vision in both eyes. A Gram-positive coccobacillus was isolated from the bloodstream, he was treated with fluoroquinolone with disappearance of fever, decreased ocular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial endocarditis; Endophthalmitis.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600011

Bilateral facial palsy associated with leptospirosis
Provedor de dados: 55
Autores: Silva,Andressa Alves da; Ducroquet,Marcelo; Pedrozo Junior,Jeff Chandler.
Leptospirosis is a zoonosis of worldwide occurrence caused by the spirochete Leptospira interrogans. It is an acute feverish disease with a broad clinical spectrum and follows a characteristic biphasic course. Bilateral facial palsy is a rare clinical condition and the differential diagnosis of its causes is extensive. The objective of this exploratory study, presented as a case report, is to describe the occurrence of bilateral facial palsy as an unusual manifestation of leptospirosis. This suggestion should not be overlooked when analyzing the causes for bilateral facial palsy, and should be considered with other possible differential diagnoses, some of which are potentially fatal.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Leptospirosis; Bilateral facial palsy.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400017

Bilateral geographical ulcer in a neonate
Provedor de dados: 55
Autores: Arora,Priyanka; Ganesh,Suma; Arora,Kamaldeep; Das,Rashmi Ranjan.
Tipo: Info:eu-repo/semantics/report
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100096

Bilateral peripheral facial palsy secondary to lymphoma in a patient with HIV/AIDS: a case report and literature review
Provedor de dados: 55
Autores: Sasaki,Maria das Graças; Leite,Patrícia G. B.; Leite,Andréa G. B.; Almeida,Sérgio Monteiro de.
Neurological complications represent one of the most important causes of morbidity and mortality in patients with HIV/AIDS. However, peripheral neuropathy comprises only 5% to 20% of the total neurological complications and facial nerve palsy, especially when it is bilateral, is a less common manifestation. Peripheral facial palsy has been considered as a possible neurological complication of the early stage of HIV infection but the number of reported cases in the literature is limited. Histological findings of nervous tissue in peripheral facial palsy at an early stage of HIV infection include a degenerative and not suppurative inflammatory process, but its etiology remains obscure. Peripheral facial palsy in the late stage of HIV infection is...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Facial palsy; Lymphoma.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100008

Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Provedor de dados: 55
Autores: Amini,Marzyeh; Nahrevanian,Hossein; Khatami,Shohreh; Farahmand,Mahin; Mirkhani,Fatemeh; Javadian,Seifoddin.
Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Balb/c; C57bl/6; CL; Iran; Leishmania major; Treatment; Cu; Zn.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002

Biocide activity of microfiber mops with and without silver after contamination
Provedor de dados: 55
Autores: Lorenzi,Sonia De; Romanini,Letizia; Finzi,Gianfranco; Salvatorelli,Germano.
OBJECTIVE: The purpose of the present research was to compare the residual microbial load in Solo System microfiber mops with silver and in normal microfiber mops without silver to see whether those with the silver prevent bacterial proliferation and spread more effectively during normal cleaning operations. METHODS: Mops with and without silver were experimentally contaminated with suspension of Staphylococcus aureus ATCC 6538. The bioburden was evaluated by a filtering procedure according to UNI EN 1174 after contamination, after washing and after different times of impregnation in an alcohol-base detergent. RESULTS AND DISCUSSION: The results obtained lead to the conclusion that silver microfiber mop was significantly more effective in reducing...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Decontamination; Surface-active agents; Products with antimicrobial action; Semi-colon; Infection control.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300003

Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing
Provedor de dados: 55
Autores: Lima,Jailton Lobo da Costa; Alves,Lilian Rodrigues; Jacomé,Paula Regina Luna de Araújo; Bezerra Neto,João Pacífico; Maciel,Maria Amélia Vieira; Morais,Marcia Maria Camargo de.
ABSTRACT  Introduction: Biofilm production is an important mechanism for the survival of Pseudomonas aeruginosa and its relationship with antimicrobial resistance represents a challenge for patient therapeutics. P. aeruginosa is an opportunistic pathogen frequently associated to nosocomial infections, especially in imunocompromised hosts.  Objectives: Analyze the phenotypic biofilm production in P. aeruginosa isolates, describe clonal profiles, and analyze quorum sensing (QS) genes and the occurrence of mutations in the LasR protein of non-biofilm producing isolates.  Methods: Isolates were tested for biofilm production by measuring cells adherence to the microtiter plates. Clonal profile analysis was carried out through ERIC-PCR, QS genes were by specific...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Biofilm; Multiresistance; Quorum sensing (QS).
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200129

Biofilm production using distinct media and antimicrobial susceptibility profile of Pseudomonas aeruginosa
Provedor de dados: 55
Autores: Perez,Leandro Reus Rodrigues; Barth,Afonso Luís.
Biofilm production is an important mechanism for bacterial survival and its occurrence together with antimicrobial resistance represents a challenge for clinical management. Here, we evaluated the ability for biofilm production among P. aeruginosa isolates from patients with or without cystic fibrosis (CF) using two distinct media, besides determining the antimicrobial susceptibility profile of these isolates for eight antimicrobial agents. The ability for biofilm production when TSB medium was used was higher than when used CF sputum media (p = 0.0198). However, P. aeruginosa isolates from CF have demonstrated similar performance for biofilm production, independently of the medium used. Besides, among the biofilm-producing isolates, those recovered from...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biofilm; Pseudomonas aeruginosa; Cystic fibrosis; Antimicrobial resistance.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400001

Biofilms: microbes and disease
Provedor de dados: 55
Autores: Aparna,Madhu Sharma; Yadav,Sarita.
Bacteria that attach to surface aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. These represent microbial societies with their own defense and communication system. Transitioning from acute to chronic infection is frequently associated with biofilm formation.Bacteria in biofilms are innately more resistant to antimicrobial agents. The presence of indwelling medical devices increases the risk for biofilm formation and subsequent infection. The current antibiotic therapies are of limited effectiveness in resolving biofilms infection.This review attempts to discuss the stages in biofilm formation, their pathogenic mechanisms, effect of antimicrobial agents, detection and eradication of the biofilms.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biofilms; Staphylococci; Pseudomonas; Candida.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600016

BKV-infection in kidney graft dysfunction
Provedor de dados: 55
Autores: Montagner,Juliana; Michelon,Tatiana; Fontanelle,Barbara; Oliveira,Alexandre; Silveira,Janaina; Schroeder,Regina; Neumann,Jorge; Keitel,Elizete; Alexandre,Claudio Osmar Pereira.
INTRODUCTION: BKV nephropathy (BKN) causes kidney graft loss, whose specific diagnosis is invasive and might be predicted by the early detection of active viral infection. OBJECTIVE: Determine the BKV-infection prevalence in late kidney graft dysfunction by urinary decoy cell (DC) and viral DNA detection in urine (viruria) and blood (viremia; active infection). METHODS: Kidney recipients with &gt;1 month follow-up and creatinine &gt;1.5 mg/dL and/or recent increasing &gt;20% (n = 120) had their urine and blood tested for BKV by semi-nested PCR, DC searching, and graft biopsy. PCR-positive patients were classified as 1+, 2+, 3+. DC, viruria and viremia prevalence, sensitivity, specificity, and likelihood ratio (LR) were determined (Table 2x2). Diagnosis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: BK virus; Decoy cells; Kidney transplantation; PCR; Viremia; Viruria.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200010

blaGES carrying Pseudomonas aeruginosa isolates from a public hospital in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Pellegrino,Flávia L. P. C.; Netto-dos Santos,Kátia R.; Riley,Lee W.; Moreira,Beatriz M.
Previous analysis of Pseudomonas aeruginosa class-1 integrons from Rio de Janeiro, Brazil, revealed the blaGES gene in one isolate. We screened isolates of two widespread PFGE genotypes, A and B, at a public hospital in Rio, for the presence of blaGES. The gene was detected in all seven P. aeruginosa isolates belonging to genotype B. Three of the seven genotype-B isolates were resistant to amikacin, aztreonam, ceftazidime, cefepime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin-tazobactam and ticarcillin-clavulanic acid. The other four isolates were resistant to all these agents, except gentamicin, imipenem, meropenem and piperacillin-tazobactam. A synergistic effect between ceftazidime and imipenem or clavulanic acid suggested the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa blaGES; Antibiotics public hospital Rio de Janeiro Brazil.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400007

Blastocystis infection in patients with chronic renal disease
Provedor de dados: 55
Autores: Salinas,Jorge Luis.
Tipo: Info:eu-repo/semantics/other
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100001

Blastocystis sp. and other intestinal parasites in hemodialysis patients
Provedor de dados: 55
Autores: Kulik,Rose Anne; Falavigna,Dina Lúcia Morais; Nishi,Letícia; Araujo,Silvana Marques.
Chronic renal insufficiency disease (CRI) leads to uremia in hemodialysis patients and induces a state of immunodepression that results in higher frequencies of infections and diarrhea. Hemodialysis patients resident in the city of Campo Mourão, Paraná, Brazil were analyzed from April 2006 through September 2007 for Blastocystis sp. and other intestinal parasites and for associated diarrhea. Fecal samples from 86 hemodialysis patients and 146 healthy (reference) persons were examined by standard methods for detecting ova, larvae and cysts, which included preservation in 10% formalin and the Kinyoun method. Thirty-three hemodialysis patients (45.1%) and 36 reference individuals (25.7%) were found to be parasitized. The differences in the percentages of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blastocystis sp.; Hemodialysis patients; Parasites.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400017

Bloodstream infection by mcr-1-harboring Escherichia coli in a cancer patient in southern Brazil
Provedor de dados: 55
Autores: Lorenzoni,Vinícius Victor; Dalmolin,Tanise Vendruscolo; Franco,Laísa Nunes; Barth,Afonso Luis; Hörner,Rosmari.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400356

Bloodstream infections caused by ESBL-producing E. Coli and K. pneumoniae: risk factors for multidrug-resistance
Provedor de dados: 55
Autores: Serefhanoglu,Kivanc; Turan,Hale; Timurkaynak,Funda Ergin; Arslan,Hande.
This prospective case-control study was conducted from October 2003 to June 2007 to evaluate risk factors for multidrug resistance among extended-spectrum-b-lactamase-producing Escherichia coli and Klebsiella spp. (ESBL-EK) isolates in blood cultures. All adult patients (&gt;18 years old) whose blood cultures grew ESBL-EK during the study period were included. An ESBL-EK isolate was defined as MDR if it was resistant to at least one member of following two classes of antibiotics: aminoglycosides (amikacin, gentamicin, or netilmycin) and fluoroquinolones (ofloxacin, or ciprofloxacin). Case patients were those with a MDR ESBL-EK isolate, and control patients were those with a non-MDR ESBL-EK isolate. A total of 94 bloodstream infections, including 37 (39,4%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBLs; Multidrug resistance; Risk factors.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600003

Body composition and lipodystrophy in prepubertal HIV-infected children
Provedor de dados: 55
Autores: Palchetti,Cecilia Zanin; Patin,Rose Vega; Gouvêa,Aída de Fátima Thomé Barbosa; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Oliveira,Fernanda Luisa Ceragioli.
OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Child; Lipodystrophy; Body composition; Anthropometry.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100001

Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV
Provedor de dados: 55
Autores: Carmo,Fabiana Bononi; Terreri,Maria Teresa; Succi,Regina Célia de Menezes; Beltrão,Suenia Vasconcelos; Gouvea,Aida de Fátima Tomé Barbosa; Paulino,Erica Regina Cruz; Machado,Daisy Maria.
ABSTRACT  Background: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease.  Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval.  Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Infant; Diagnosis; Metabolism; Bone.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300270

Brazil is so far free from Candida auris. Are we missing something?
Provedor de dados: 55
Autores: Pasqualotto,Alessandro C.; Sukiennik,Teresa C.T.; Meis,Jacques F.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300149

Brazilian experience in EU-CORE: daptomycin registry and treatment of serious Gram-positive infections
Provedor de dados: 55
Autores: Timerman,Artur; Brites,Carlos; Bicudo,Eliana; Grinbaum,Renato S.; Costa Filho,Rubens; Carrilho,Claudia D.M.; Bichels,Andre; Barreto,Tânia.
OBJECTIVES: To collect data about non-controlled prescribing use of daptomycin and its impact among Brazilian patients with serious Gram positive bacterial infection, as well as the efficacy and safety outcomes. MATERIALS AND METHODS: This is a multi-center, retrospective, non-interventional registry (August 01, 2009 to June 30, 2011) to collect data on 120 patients (44 patients in the first year and 76 patients in the second year) who had received at least one dose of commercial daptomycin in Brazil for the treatment of serious Gram-positive bacterial infection. RESULTS: Right-sided endocarditis (15.8%), complicated skin and soft tissue infections (cSSTI)wound (15.0%) and bacteremia-catheter-related (14.2%) were the most frequent primary infections; lung...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Daptomycin; Methicillin-resistant; Staphylococcus aureus; Bacteremia; Endocarditis; Skin diseases; Infectious.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600004

Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical
Provedor de dados: 55
Autores: Colombo,Arnaldo Lopes; Guimarães,Thaís; Camargo,Luis Fernando Aranha; Richtmann,Rosana; Queiroz-Telles,Flavio de; Salles,Mauro José Costa; Cunha,Clóvis Arns da; Yasuda,Maria Aparecida Shikanai; Moretti,Maria Luiza; Nucci,Marcio.
Candida infections account for 80% of all fungal infections in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream infections are now a major challenge for tertiary hospitals worldwide due to their high prevalence and mortality rates. The incidence of candidemia in tertiary public hospitals in Brazil is approximately 2.5 cases per 1000 hospital admissions. Due to the importance of this infection, the authors provide a review of the diversity of the genus Candida and its clinical relevance, the therapeutic options and discuss the treatment of major infections caused by Candida. Each topography is discussed with regard to epidemiological, clinical and laboratory diagnostic and therapeutic recommendations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidiasis; Candidemia; Treatment; Antifungals.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300001

Brazilian infectious diseases specialists: who and where are they?
Provedor de dados: 55
Autores: Cassenote,Alex Jones Flores; Scheffer,Mario César; Segurado,Aluísio Augusto Cotrim.
Abstract  Background The infectious diseases specialist is a medical doctor dedicated to the management of infectious diseases in their individual and collective dimensions.  Objectives The aim of this paper was to evaluate the current profile and distribution of infectious diseases specialists in Brazil.  Methods This is a cross-sectional study using secondary data obtained from institutions that register medical specialists in Brazil. Variables of interest included gender, age, type of medical school (public or private) the specialist graduated from, time since finishing residency training in infectious diseases, and the interval between M.D. graduation and residency completion. Maps are used to study the geographical distribution of infectious diseases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Communicable diseases; Infectious disease medicine; Specialization; Internship and residency; Brazil.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200141

Brazilian manicure: a potential dangerous behavior
Provedor de dados: 55
Autores: Jesus-Nunes,Ana Paula; Moreira,Tayne Miranda; Morais-de-Jesus,Mychelle; Araujo-de-Freitas,Lucas; Quarantini,Lucas C.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100109

Brazilian Society of Infectious Diseases: 25 years!
Provedor de dados: 55
Autores: Mendonça,João Silva de; Badaró,Roberto; Sousa,Anastácio Q.
Tipo: Info:eu-repo/semantics/other
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100001

Breast cancer among human immunodeficiency virus (HIV)-infected patients: the experience in Brescia, Northern Italy
Provedor de dados: 55
Autores: Calabresi,Alessandra; Ferraresi,Alice; Vavassori,Andrea; Castelli,Francesco; Quiros-Roldan,Eugenia.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400017

Breast cancer in a cohort of human immunodeficiency virus (HIV)-infected women from Rio de Janeiro, Brazil: a cases series report and an incidence rate estimate
Provedor de dados: 55
Autores: Andrade,Angela Cristina Vasconcelos de; Luz,Paula Mendes; Veloso,Valdiléa Gonçalves; Cardoso,Sandra Wagner; Moreira,Ronaldo Ismerio; Grinsztejn,Beatriz; Friedman,Ruth Khalili.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Breast neoplasms; Case reports; Incidence.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400016

Brucella melitensis: a rarely suspected cause of infections of genitalia and the lower urinary tract
Provedor de dados: 55
Autores: Stamatiou,K.; Polyzois,K.; Dahanis,S.; Lambou,T.; Skolarikos,A.
We examined the clinical presentation and outcome of Brucellar infections of genitalia and the lower urinary tract through a review of the medical records of 10 cases of male patients with brucellar infections of the genitalia and lower urinary tract. The mean age of the patients with brucellosis was 49.2, (median 52, range 15-77 years). Eleven out of 17 patients were rural residents, 15 reported that they might have consumed unpasteurized dairy products) and four reported occupational exposure. Symptoms onset was acute in almost all cases. Scrotal pain, epidedimal swelling and fever were the most common symptoms. The Wright test was positive in 13 patients, while Brucella sp. was isolated from blood cultures in six cases. Only two patients were found with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Human brucellosis; Epididymoorchitis; Brucellar infections; Occupational exposure.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200003

Brucella peritonitis and leucocytoclastic vasculitis due to Brucella melitensis
Provedor de dados: 55
Autores: Dizbay,Murat; Hizel,Kenan; Kilic,Selcuk; Mutluay,Ruya; Ozkan,Yavuz; Karakan,Tarkan.
Brucellosis is a multisystemic disease that rarely leads to a fatal outcome. While reticuloendothelial system organs are mostly affected, peritonitis and posthepatitic cirrhosis are also complications of brucellosis, though they are very rare. Brucella spp. can also trigger immunological reactions. We report a case of brucellosis with peritonitis, renal failure and leucocytoclastic vasculitis caused by Brucella melitensis, which led to a fatal outcome. Brucellosis should be considered in the differential diagnosis of vasculitic diseases, especially in endemic areas.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Brucella melitensis; Peritonitis; Cirrhosis; Leucocytoclastic vasculitis; Cryoglobulinemia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400017

Brucellar epididymo-orchitis in southeastern part of Turkey: an 8 year experience
Provedor de dados: 55
Autores: Celen,Mustafa Kemal; Ulug,Mehmet; Ayaz,Celal; Geyik,Mehmet Faruk; Hosoglu,Salih.
OBJECTIVE: the different clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis (BEO) reporting to the reference hospital in Southeastern Anatolia of Turkey. MATERIAL AND METHODS: in this study, 27 male patients with brucellosis, who presented with epididymitis or epididymo-orchitis (EO) at the university hospital in Diyarbakir from 1998 to 2006, were included. They were compared with the other male patients. Positive blood culture or high agglutination titers of &gt; 1/160 and positive clinical manifestations of brucellosis were the main criteria for diagnosing brucellosis. RESULTS: fourteen patients had unilateral EO. Leukocytosis was present in 10 patients; all of them had initial agglutination...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Epididymo-orchitis; Brucellosis; Turkey; Medical treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100021

"Bunch of grapes" on the spine-spinal hydatidosis
Provedor de dados: 55
Autores: Zhang,Zhicheng; Li,Fang; Zhao,Guangmin; Sun,Tiansheng.
Tipo: Info:eu-repo/semantics/article
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300022

Burkitt Non-Hodgkin Lymphoma in childhood
Provedor de dados: 55
Autores: Barreto,José Henrique.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500029

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis
Provedor de dados: 55
Autores: Gatti,Luciano Lobo; Lábio,Roger de; Silva,Luiz Carlos da; Smith,Marília de Arruda Cardoso; Payão,Spencer Luiz Marques.
Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori infection; CagA; Inflammatory infiltrate.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400008

Candida albicans meningitis in an infant with noonan syndrome
Provedor de dados: 55
Autores: Ahmadi,Faezeh; Ahmadi,Maedeh; Yaghmaei,Bahareh; Nejat,Farideh; Rezaei,Nima; Mamishi,Setareh.
Noonan syndrome is a rare disorder, characterized by several malformations such as dysplasia and stenosis of the pulmonary valve, atrial septal defect and a typical pattern of hypertrophic cardiomyopathy. We describe here a 1-month old girl, who was referred to our center with seizure and apnea. She had wide anterior fontanel, head circumference and sunset eye. Intaventricular hemorrhage by sonography and atrial septal defect and hypertrophy cardiomyopathy by echocardiography were detected. Clinical and laboratory findings of the patient were compatible with a diagnosis of Noonan syndrome, which was also confirmed by molecular analysis. Candida albicans was grown in the blood and cerebrospinal fluid cultures. Treatment with Amphotrycine B was started for...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Candida barbicans meningitis; Noonan syndrome.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600012

Candida species isolated from the vaginal mucosa of HIV-infected women in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Oliveira,Paula Matos; Mascarenhas,Rita Elizabeth; Lacroix,Claire; Ferrer,Suzana Ramos; Oliveira,Rone Peterson C; Cravo,Elaine Andrade; Alves,André P Ribeiro; Grassi,Maria Fernanda Rios.
BACKGROUND: Vulvovaginal candidiasis (VVC) is the second most common vaginal infection. HIV-infection is a risk factor for this infection. OBJECTIVE: To determine the frequency of VVC and to describe the main Candida species isolated and their susceptibility to antifungal drugs in HIV-infected patients, compared to HIV-uninfected women in Salvador, Brazil. METHODS: Cross-sectional study including a group of 64 HIV-infected women and 76 uninfected women, followed up at the AIDS reference center and at the Gynecological Clinic of Escola Bahiana de Medicina e Saúde Pública (Salvador, Bahia, Brazil). RESULTS: Frequency of Candida spp. was higher in HIV-infected women (29.7%) than in HIV-uninfected controls (14.5%) (p = 0.02). The odds ratio value for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV Candida candidiasis; Vulvovaginal.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300010

Candida tropicalis as an emerging pathogen in Candida meningitis: case report and review
Provedor de dados: 55
Autores: Goldani,Luciano Z; Santos,Rodrigo P.
Candida species are an uncommon cause of meninigitis. Given the rarity of this infection, the epidemiology, prognosis, and optimal therapy for Candida meningitis are poorly defined. The authors report on a paraplegic patient due to spinal cord injury who developed C. tropicalis meningitis. In addition, we review and discuss other reported cases of C. tropicalis meningitis in the medical literature
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Candida; Meningitis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600014

Candida tropicalis in the peripheral blood of a surgical patient
Provedor de dados: 55
Autores: Pasqualotto,Alessandro Comarú; Biermann,Maristela Bittencourt.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100019

Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex
Provedor de dados: 55
Autores: Motta,Adriana Lopes; Almeida,Gisele Madeira Duboc de; Almeida Júnior,João Nóbrega de; Burattini,Marcelo Nascimento; Rossi,Flávia.
INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidemia; Candida spp; Susceptibility testing; Candida epidemiology; Candida Etest; Antifungal susceptibility profile; Candida antifungal agents; Azoles.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004

Carbapenem stewardship: positive impact on hospital ecology
Provedor de dados: 55
Autores: Lima,Ana Lucia Lei Munhoz; Oliveira,Priscila Rosalba Domingos de; Paula,Adriana Pereira de; Dal-Paz,Karine; Almeida Jr,João Nóbrega de; Félix,Cássia da Silva; Rossi,Flávia.
INTRODUCTION: Excessive group 2 carbapenem use may result in decreased bacterial susceptibility. OBJECTIVE: We evaluated the impact of a carbapenem stewardship program, restricting imipenem and meropenem use. METHODS: Ertapenem was mandated for ESBL-producing Enterobacteriaceae infections in the absence of non-fermenting Gram-negative bacilli (GNB) from April 2006 to March 2008. Group 2 carbapenems were restricted for use against GNB infections susceptible only to carbapenems and suspected GNB infections in unstable patients. Cumulative susceptibility tests were done for nosocomial pathogens before and after restriction using Clinical and Laboratory Standards Institute (CLSI) guide-lines.Vitek System or conventional identification methods were performed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenems; Drug resistance; Bacterial ecology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100001

Carbapenemase KPC-2 in ESBL-producing Enterobacteriaceae from two clinics from Villavicencio, Colombia
Provedor de dados: 55
Autores: Martinez,Pedro; Sanchez,Liliana; Mattar,Salim.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100100

Carbapenem-resistant and cephalosporin-susceptible: a worrisome phenotype among Pseudomonas aeruginosa clinical isolates in Brazil
Provedor de dados: 55
Autores: Campana,Eloiza Helena; Xavier,Danilo Elias; Petrolini,Fernanda Villas-Boas; Cordeiro-Moura,Jhonatha Rodrigo; Araujo,Maria Rita Elmor de; Gales,Ana Cristina.
Abstract The mechanisms involved in the uncommon resistance phenotype, carbapenem resistance and broad-spectrum cephalosporin susceptibility, were investigated in 25 Pseudomonas aeruginosa clinical isolates that exhibited this phenotype, which were recovered from three different hospitals located in São Paulo, Brazil. The antimicrobial susceptibility profile was determined by CLSI broth microdilution. β-lactamase-encoding genes were investigated by PCR followed by DNA sequencing. Carbapenem hydrolysis activity was investigated by spectrophotometer and MALDI-TOF assays. The mRNA transcription level of oprD was assessed by qRT-PCR and the outer membrane proteins profile was evaluated by SDS-PAGE. Genetic relationship among P. aeruginosa isolates was assessed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gram-negative bacilli; Carbapenem resistance; OprD porin.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100057

Carbapenem-resistant GES-5-producing Klebsiella pneumoniae in Southern Brazil
Provedor de dados: 55
Autores: Ribeiro,Vanessa Bley; Falci,Diego R.; Rozales,Franciéli P.; Barth,Afonso L.; Zavascki,Alexandre P.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200231

Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care units: risk factors for progression to infection
Provedor de dados: 55
Autores: Akturk,Hacer; Sutcu,Murat; Somer,Ayper; Aydın,Derya; Cihan,Rukiye; Ozdemir,Aslı; Coban,Asuman; Ince,Zeynep; Citak,Agop; Salman,Nuran.
Abstract  Background Little is known about factors associated with carbapenem-resistant Klebsiella pneumoniae infections in pediatric patients, who are initally colonized with carbapenem-resistant Klebsiella pneumoniae.  Materials and methods A retrospective case–control study was conducted involving pediatric and neonatal intensive care units throughout a five-year period (January 2010–December 2014). Clinical and microbiological data were extracted from Hospital Infection Control Committee reports and patients’ medical records. Risk factors were assessed in carbapenem-resistant Klebsiella pneumoniae colonized patients who developed subsequent systemic infection (cases) and compared to carbapenem-resistant Klebsiella pneumoniae colonized patients who did...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenem resistant Klebsiella pneumoniae; Infection; Colonization; Pediatric/Neonatal intensive care.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200134

Carbapenem-resistant Pseudomonas aeruginosa: clonal spread in southern Brazil and in the state of Goiás
Provedor de dados: 55
Autores: Scheffer,Mara Cristina; Gales,Ana Cristina; Barth,Afonso Luis; Carmo Filho,José Rodrigues do; Dalla-Costa,Libera Maria.
This study evaluated the clonal spread of carbapenem-resistant P. aeruginosa producing SPM-1 type metallo-Î²-lactamase (MBL), at the university hospital of Florianópolis, Santa Catarina, Brazil, compared to an epidemic clone previously reported, as well as strains collected in other three Brazilian states. Among the isolates, 17 (62%) were clonal and highly related to strains from other regions of Brazil. Six clonal strains harbored the blaSPM-1 gene. The finding of a unique SPM-1 producer clone suggests that its dissemination has contributed to the high resistance to carbapenems in Brazilian hospitals
Tipo: Info:eu-repo/semantics/other
Palavras-chave: P. aeruginosa; Carbapenem resistance; Metallo- Β-lactamase.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500014

Carbapenem-resistant Pseudomonas aeruginosa outbreak in an intensive care unit of a teaching hospital
Provedor de dados: 55
Autores: Gales,Ana C.; Torres,Patrícia L.; Vilarinho,Dominique S. O.; Melo,Renata S.; Silva,Claudinéia F. L.; Cereda,Rosângela F.
The genetic similarity of carbapenem-resistant Pseudomonas aeruginosa strains isolated in the Hospital Universitário São Francisco, Bragança Paulista, São Paulo, Brasil, was evaluated by pulsed field gel electrophoresis (PFGE). A unique clone was detected among 5 of 7 isolates, suggesting that cross-contamination might have played a role in the spread of carbapenem-resistant P. aeruginosa strains. Interestingly, a similar PFGE pattern was encountered in a P. aeruginosa strain isolated from Hospital São Paulo that was used as a PFGE control.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; PFGE; Carbapenem.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400001

Cardiac complications associated with the influenza viruses A subtype H7N9 or pandemic H1N1 in critically ill patients under intensive care
Provedor de dados: 55
Autores: Wang,Jiajia; Xu,Hua; Yang,Xinjing; Zhao,Daguo; Liu,Shenglan; Sun,Xue; Huang,Jian-an; Guo,Qiang.
Abstract  Background and objective: The clinical presentations and disease courses of patients hospitalized with either influenza A virus subtype H7N9 (H7N9) or 2009 pandemic H1N1 influenza virus were compared in a recent report, but associated cardiac complications remain unclear. The present retrospective study investigated whether cardiac complications in critically ill patients with H7N9 infections differed from those infected with the pandemic H1N1 influenza virus strain.  Methods: Suspect cases were confirmed by reverse transcription polymerase chain reaction assays with specific confirmation of the pandemic H1N1 strain at the Centers for Disease Control and Prevention. Comparisons were conducted at the individual-level data of critically ill...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiac complications; H7N9; H1N1.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100012

Cardiovascular disease in human immunodeﬁciency virus-infection as a cause of hospitalization: a case-series in a General Hospital in Peru
Provedor de dados: 55
Autores: Valenzuela-Rodríguez,Germán; Mezones-Holguín,Edward; Mendo-Urbina,Fernando; Rodríguez-Morales,Alfonso J.
Background: Cardiovascular disease in the context of human immunodeﬁciency virus infection has become a major clinical concern in recent years. In the current report we assess hospitalizations due to cardiovascular disease in human immunodeﬁciency virus patients in a Social Security reference hospital in Peru.Methods:A retrospective study was carried out between January 1996 and December 2012 in a General Hospital in Lima, Peru.Results: We included 26 patients hospitalized due to cardiovascular disease. Mean age was 46.3 years (SD 12.5), predominantly male (57.7%). Ten patients (38.4%) were in Acquired Immunodeﬁciency Syndrome stages. Seventeen (65.4%) received high-active-antiretroviral therapy. Eleven (42.3%) had cardiac involvement and 15 (57.7%) had...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cardiovascular diseases; HIV; Acquired Immunodeﬁciency; Syndrome; Peru.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400431

Cardiovascular risk profile in patients with myelopathy associated with HTLV-1
Provedor de dados: 55
Autores: Prado,Fabio Luís Silva do; Prado,Renata; Ladeia,Ana Marice Teixeira.
ABSTRACT HAM/TSP (HTLV-1-associated myelopathy/tropical spastic paraparesis) is a slowly progressive disease, characterized by a chronic spastic paraparesis. It is not known if the disease carries an independent risk for cardiovascular disease. The objective of this study was to evaluate the cardiovascular risk profile related to HAM/TSP and compare it with the general population.  Methods: This was a cross-sectional study, with a control group. HAM/TSP patients were evaluated using cardiovascular risk scores (ASCVD RISK, SCORE and Framingham) and inflammatory markers (ultrasensitive CRP and IL-6), and compared with a control group of healthy individuals. We also evaluated the correlation between cardiovascular risk and the functional status of patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; HAM/TSP; Cardiovascular risk; C reactive protein; Interleukin-6.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300226

Carriage of methicillin resistant Staphylococcus aureus and awareness of infection control among health care workers working in intensive care unit of a hospital in Nepal
Provedor de dados: 55
Autores: Pant,Narayan Dutt; Sharma,Manisha.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200218

Carriage prevalence of Neisseria meningitidis in the Americas in the 21st century: a systematic review
Provedor de dados: 55
Autores: Santos-Neto,José Francisco; Ferreira,Viviane Matos; Feitosa,Caroline Alves; Martinez-Silveira,Martha Silvia; Campos,Leila Carvalho.
Abstract Neisseria meningitidis is a bacterium that colonizes the human nasopharynx and is transmitted by respiratory droplets from asymptomatic or symptomatic carriers. Occasionally, the pathogen invades the mucosa and enters the bloodstream, causing invasive meningococcal disease, a life-threatening infection. While meningococcal colonization is the first step in the development of invasive disease, the risk factors that predict progression from asymptomatic to symptomatic status are not well-known. The present report aimed to describe the prevalence of N. meningitidis carriers throughout the Americas, emphasizing the risk factors associated with carrier status, as well as the most prevalent serogroups in each studied population. We conducted a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Carrier; America; Epidemiology; Vaccine.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400254

Cascade of access to interventions to prevent HIV mother to child transmission in the metropolitan area of Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Araujo,Elaine S. Pires; Friedman,Ruth Khalili; Camacho,Luis Antonio Bastos; Derrico,Monica; Moreira,Ronaldo Ismério; Calvet,Guilherme Amaral; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Pilotto,José Henrique; Grinsztejn,Beatriz.
OBJECTIVES: To describe the access to the interventions for the prevention of Human Immunodeficiency Virus (HIV) mother to child transmission and mother to child transmission rates in the outskirts of Rio de Janeiro, from 1999 to 2009.METHODS: This is a retrospective cohort study. Prevention of HIV mother to child transmission interventions were accessed and mother to child transmission rates were calculated.RESULTS: The study population is young (median: 26 years; interquartile range: 22.0-31.0), with low monthly family income (40.4% up to one Brazilian minimum wage) and schooling (62.1% less than 8 years). Only 47.1% (n = 469) knew the HIV status of their partner; of these women, 39.9% had an HIV-seronegative partner. Among the 1259 newborns evaluated,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HIV vertical transmission; Antiretroviral chemoprophylaxis; Cohort studies; Brazil.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300252

Case of recurrent Paracoccidioidomycosis: 25 years after initial treatment
Provedor de dados: 55
Autores: Araújo,Stanley de Almeida; Prado,Laura de Godoy Rousseff; Veloso,Juliana Marcia Ribeiro; Pedroso,Enio Roberto Pietra.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500017

Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient
Provedor de dados: 55
Autores: Barone,Bianca; Kreuzig,Patrícia Lago; Gusmão,Patricia Medeiros; Chamié,Daniel; Bezerra,Sabrina; Pinheiro,Pedro; Coscarelli,Pedro; Paiva,Daurita; Fonseca,Leila; Marsico,Anna; Cirigliano,André; Perez,Mário.
We describe a case of a male patient, 38 years old, HIV-positive (most recent CD4 count about 259/mm³), with abdominal pain, nausea, vomiting, anorexia, weight loss, and vespertine high fever with chills. His hemogram showed normocytic and normochromic anemia, with a high erythrocyte sedimentation rate (ESR) and gross granulations in the neutrophils. Transaminases were normal. Bone marrow biopsy evidenced a chronic disease anemia pattern and a lack of infectious agents. Abdominal ultrasound examination showed a normal-size spleen, which exhibited heterogeneous parenchyma and multiple small hypoechoic images, together with small ascites, peripancreatic and para-aortic lymphadenopathy. These findings were confirmed by abdominal CT. The liver was normal in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; HIV; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200014

Case report: spontaneous rupture of the spleen due to dengue fever
Provedor de dados: 55
Autores: Miranda,L.E.C.; Miranda,S.J.C.; Rolland,M.
Spontaneous rupture of the spleen has been described in cases of hematologic, neoplasic and infectious diseases, or resulting from pancreatitis. We report a rare case of spontaneous splenic rupture, and favorable evolution after splenectomy, in a patient with dengue fever, which occurred during the last outbreak of dengue fever in Brazil.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Spleen; Rupture; Dengue fever.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600011

Case reports and qualitative research: two important approaches to evaluation and communication in medical science
Provedor de dados: 55
Autores: Jones,Thomas C.
Tipo: Info:eu-repo/semantics/other
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300009

Case-case-control study of risk factors for nasopharyngeal colonization with methicillin-resistant Staphylococcus aureus in a medical-surgical intensive care unit
Provedor de dados: 55
Autores: Melo,Edson Carvalho de; Fortaleza,Carlos Magno Castelo Branco.
Nasopharyngeal colonization with methicillin-resistant Staphylococcus aureus (MRSA) often precedes the development of nosocomial infections. In order to identify risk factors for MRSA colonization, we conducted a case-case-control study, enrolling 122 patients admitted to a medical-surgical intensive care unit (ICU). All patients had been screened for nasopharyngeal colonization with S. aureus upon admission and weekly thereafter. Two case-control studies were performed, using as cases patients who acquired colonization with MRSA and methicillin-susceptible S. aureus (MSSA), respectively. For both studies, patients in whom colonization was not detected during ICU stay were selected as control subjects. Several potential risk factors were assessed in...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Methicillin-resistant Staphylococcus aureus; Nasopharyngeal colonization; Intensive care unit.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600002

Cases of Opsi syndrome still candidate for medical ICU
Provedor de dados: 55
Autores: Aygencel,Gulbin; Dizbay,Murat; Turkoglu,Melda Aybar; Tunccan,Ozlem Guzel.
Splenectomized patients are likely to suffer from severe infections, such as sepsis and meningitis, which is called overwhelming postsplenectomy infection (OPSI) syndrome. It seems to be more common in children, but occurs at all ages. The risk is greatest in the early months and years after operation, but never disappears entirely. The course is rapid, the clinical symptoms are serious, and the prognosis is very poor. In this paper, three cases of OPSI syndrome are described, in which infection developed 8, 8 and 15 years after splenectomy; two of the patients died. With the help of these case reports, we want to again emphasize the importance of vaccination, antibiotic prophylaxis and seeking earlier medical attention in splenectomized patients.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Overwhelming postsplenectomy infection (OPSI) syndrome; Splenectomy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600024

Cat scratch disease complicated with aseptic meningitis and neuroretinitis
Provedor de dados: 55
Autores: Pinto Jr.,Vitor Laerte; Curi,André Land; Pinto,Adriana da Silva; Nunes,Estevão Portela; Teixeira,Maria de Lourdes Benamor; Rozental,Tatiana; Favacho,Alexsandra Rodrigues; Lemos,Elba Regina Sampaio de; Bóia,Márcio Neves.
Cat scratch disease (CSD) is a self limited condition characterized by fever, lymph node enlargement and less often eye involvement. Central nervous system involvement by Bartonella henselae infection is possibly an important cause of morbidity; its role as an agent of aseptic meningitis is unknown. We report a case of a 40 years-old man with CSD accompanied by aseptic meningitis and neuroretinitis. Serum indirect immmunofluorescence (IFI) assays for B. henselae were positive and the cerebrospinal fluid (CSF) analysis showed mononuclear pleocytosis and increased level of protein. Serological tests for other etiologies were negative. The patient responded well to antibiotic therapy with oral doxycicline plus rifampin and in the 12th day of hospitalization...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cat scratch disease; Bartonella henselae; Aseptic meningitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200013

"Catarrhal physiognomy" and Koplik's spots
Provedor de dados: 55
Autores: Li,Zhengxiao; Zhao,Wenxue; Ji,Fanpu.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400017

Categorization of dengue fever according to phase of illness-a suggestion for clinical studies using single diagnostic sample
Provedor de dados: 55
Autores: Bhaskar,Emmanuel; Praveena,Raveendran; Sowmya,Gopalan; Moorthy,Swathy.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500021

Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review
Provedor de dados: 55
Autores: Londero,Marcos Rech; Zanrosso,Crisley Dossin; Corso,Leandro Luis; Michelin,Lessandra; Soldera,Jonathan.
ABSTRACT  Background: Papiliotrema laurentii is one of several non-neoformans cryptococci that have rarely been associated with human infection, since it was previously considered saprophyte and thought to be non-pathogenic to humans. Nevertheless, increasing number of reports of human infection have emerged in recent years, mostly in oncologic patients.  Aim: To report a case of a female patient with pyloric obstructive cancer with a catheter-related Papiliotrema laurentii blood stream infection and systematically review the available evidence on P. laurentii infection in humans.  Methods: Retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcus; Papiliotrema; Catheter-related infections; Amphotericin B; Stomach neoplasms.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600451

Catheter-related infections in a northwestern São Paulo reference unit for burned patients care
Provedor de dados: 55
Autores: Campos Júnior,Cláudio Penido; Sanches,Patrícia; Tedokon,Elizabete Aparecida; Souza,Ana Carolina Remondi; Machado,Ricardo Luiz Dantas; Rossit,Andréa Regina Baptista.
Despite improvements in care and rehabilitation of burned patients, infections still remain the main complication and death cause. Catheter-related infections are among the four most common infections and are associated with skin damage and insertion site colonization. There are few studies evaluating this kind of infection worldwide in this special group of patients. Padre Albino Hospital Burn Care Unit (PAHBCU) is the only reference center in the Northwestern São Paulo for treatment of burned patients. This paper presents the results of a retrospective study aiming at describing the epidemiological and clinical features of catheter-related infections at PAHBCU.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Catheter; Infections; Burns; Bacteria.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200009

Causes of death among people living with HIV/AIDS in Brazil
Provedor de dados: 55
Autores: Rezende,Erika Luiza Lage Fazito; Vasconcelos,Ana Maria Nogales; Pereira,Mauricio Gomes.
BACKGROUND: The monitoring of the underlying causes of death in people living with HIV/AIDS is important so that actions to reduce morbidity and mortality can be taken. OBJECTIVE: To describe the temporal trends of underlying causes of death among people living with HIV/AIDS between 2000 and 2007 in Brazil and to identify factors associated with it. METHODS: The Mortality Information System data for deaths occurred in Brazil between 2000 and 2007 that contained reference to HIV/AIDS in any of the death certificate fields was analyzed. Temporal trends of the underlying cause of death were studied. Differences in the underlying cause of death according to gender, age, region of residence, level of education, certifying officer, race and year of death were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Causes of death; HIV.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600003

Causes of hospitalization among extra-European Union children in a large hospital of Northern Italy, in a five-year observation period
Provedor de dados: 55
Autores: Sabbatani,Sergio; Baldi,Elena; Manfredi,Roberto.
The hospitalizations of 1,239 patients aged 14 years or less and immigrated from extra-European Union countries in Italy were assessed in the 6-year period, from 1999 to 2004. The main demographic and clinical features were analyzed according to several variables, also distiguishing patients aged less than one year, from those aged 1-14 years. The introduction of a deed of indemnity law in 2001 profoundly changed the pattern of admissions and health care needs and exploitation during subsequent years, leading to a massive regularization of clandestine immigrants.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Children; Diseases; Extra-European Union; Hospital admission; Temporal trend.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100003

CCR5 genotypes and progression to HIV disease in perinatally infected children
Provedor de dados: 55
Autores: Angelis,Daniela Souza Araújo de; Freire,Wilton Santos; Pannuti,Cláudio Sergio; Succi,Regina Célia de Menezes; Machado,Daisy Maria.
The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The aim of this study was to describe the CCR5 genotypes and the characteristics of HIV disease progression in perinatally infected children. From a total of 51 children analyzed for the CCR5-del32 mutation, 18 (35%) were considered to be rapid progressors, 28 (55%) were moderate progressors and 5 (10%) were slow progressors. A portion of the CCR5 gene was amplified by PCR from genomic DNA followed by agarose gel electrophoresis. Forty-nine children (96%) carried...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; CCR5 co-receptor; HIV disease progression; Perinatally infected children.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200004

CD4+ cell counts in patients with different clinical manifestations of tuberculosis
Provedor de dados: 55
Autores: Davoudi,Setareh; Rasoolinegad,Mehrnaz; Younesian,Masoud; Hajiabdolbaghi,Mahboubeh; Soudbakhsh,Abdolreza; Jafari,Sirous; EmadiKouchak,Hamid; Mehrpouya,Morteza; Lotfi,Hossein.
Tuberculosis is the prototype of infections that require a cellular immune response for their control. It has been shown that CD4+ T-lymphocytes are most important in the protective response against Mycobacterium tuberculosis. CD8+ T-lymphocytes are also important for effective T-cell immune response. This study compares CD4+ and CD8+ baseline values in patients with different manifestations of tuberculosis. CD4+ and CD8+ in three groups of patients with tuberculosis (pulmonary, lymphadenitis, meningitis/milliary involvement) and a group of healthy volunteers were enumerated using flowcytometry. Twenty-six patients with pulmonary tuberculosis, 10 with adenitis, 16 with meningitis or milliary tuberculosis and 16 healthy volunteers entered the study. Mean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Mycobacterium tuberculosis; CD4.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600008

CD81 binding regions of hepatitis C virus remain conserved after liver transplantation
Provedor de dados: 55
Autores: Lyra,Andre C.; Fan,Xiaofeng; Di Bisceglie,Adrian M.
CD81 is a surface-associated protein expressed in the membranes of mammalian cells. It has been suggested that CD81 interacts with hepatitis C virus E2 protein, and thus might facilitate the entry of HCV into hepatocytes. The envelope-binding site appears to involve amino acids (aa) 480-493 and 544-551 within the E2 glycoprotein. Little is known about the quasispecies genetic diversity of these two regions. We studied four patients who underwent transplantation for HCV-related cirrhosis and who developed recurrent hepatitis C. We evaluated HCV quasispecies diversity in serum samples obtained at the time of transplantation and at several time points thereafter. Quasispecies diversity was assessed by cloning and sequencing of viral isolates, with computer...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C virus; CD81; Diversity.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200002

Cefepime restriction improves gram-negative overall resistance patterns in neonatal intensive care unit
Provedor de dados: 55
Autores: Araujo,Orlei Ribeiro de; Silva,Dafne Cardoso Bourguignon da; Diegues,Ana Regina; Arkader,Ronaldo; Cabral,Eloíza Aparecida Ferreira; Afonso,Marta Rodriguez; Louzada,Maria Eduarda; Albertoni,Andréa de Cássia Stéfano.
Antibiotic restriction can be useful in maintaining bacterial susceptibility. The objective of this study was verify if restriction of cefepime, the most frequently used cephalosporin in our neonatal intensive care unit (NICU), would ameliorate broad-spectrum susceptibility of Gram-negative isolates. Nine hundred and ninety-five premature and term newborns were divided into 3 cohorts, according to the prevalence of cefepime use in the unit: Group 1 (n=396) comprised patients admitted from January 2002 to December 2003, period in which cefepime was the most used broad-spectrum antibiotic. Patients in Group 2 (n=349) were admitted when piperacillin/tazobactam replaced cefepime (January to December 2004) and in Group 3 (n=250) when cefepime was reintroduced...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance; Infection control; Cefepime; Bacterial.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200022

Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae
Provedor de dados: 55
Autores: Nogueira,Keite da Silva; Daur,Alessandra Vale; Reason,Iara Taborda de Messias; Gales,Ana Cristina; Costa,Libera Maria Dalla.
The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &amp;gt; 21 and MIC &lt; 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterobacteriaceae; Beta-lactamases; Cephalosporin resistance.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014

Ceftaroline activity tested against contemporary Latin American bacterial pathogens (2011)
Provedor de dados: 55
Autores: Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.
A total of 2484 target bacterial pathogens were collected (one per patient episode) from patients in 16 Latin American medical centers located in seven nations during 2011. Isolate identity was confirmed at a coordinating laboratory and susceptibility testing was performed for ceftaroline and comparator agents according to reference broth microdilution methods. A total of 30.0% of isolates were from respiratory tract, 29.4% from skin and skin structure, 21.4% from blood stream, 7.9% from urinary tract and 11.3% from other sites. Ceftaroline was active againstStaphylococcus aureus (42.8% MRSA) with 83.6% of the isolates at &lt;1mg/L and all isolates at &lt;2mg/L (MIC5090, 0.25/2mg/L). National MRSA rates ranged from a low of 28.8% in Colombia to a high of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftaroline; Latin America; AWARE.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200187

Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013-2015)
Provedor de dados: 55
Autores: Pfaller,Michael A.; Shortridge,Dee; Sader,Helio S.; Gales,Ana; Castanheira,Mariana; Flamm,Robert K.
ABSTRACT This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor.A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries. The organisms were tested for susceptibility by broth microdilution methods as described by the CLSI M07-A10 document and the results interpreted according to EUCAST and CLSI breakpoint criteria.  Results: Ceftolozane-tazobactam...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftolozane-tazobactam; Drug resistance; Enterobacteriaceae; P. aeruginosa; Latin America; Surveillance.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600627

Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus in a patient with AIDS: case report and review of the literature
Provedor de dados: 55
Autores: Corti,Marcelo; Fioti,María F. Villafañe; Yampolsky,Claudio; Schtirbu,Ricardo; Narbaitz,Marina.
Intracranial and intraspinal involvement is a rare complication of Hodgkin's disease. We report a case of a patient with diagnosis of AIDS and Hodgkin's lymphoma who developed brain and spinal involvement at the time of the relapse of the neoplasm disease. Mixed cellularity histology was the subtype of Hodgkin's disease in our patient; we identified the Epstein-Barr virus genome in the Reed-Sternberg cells by immunohistochemistry and in situ hybridization.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hodgkin lymphoma; Central nervous system; AIDS.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600009

Central Nervous System Paracoccidioidomycosis: an overview
Provedor de dados: 55
Autores: Almeida,Sérgio Monteiro de.
Paracoccidioidomycosis (PCM) is an infectious disease, endemic to subtropical areas of Central and South America, caused by the dimorphic fungus Paracoccidioides brasiliensis. It is a chronic disease, mostly affecting adult males, with a mean patient age of 44 years. Central nervous system involvement (CNS PCM) has been found in 13% of the patients with systemic disease. We reviewed the clinical presentation, diagnosis techniques and treatments for CNS PCM.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paracoccidioidomycosis; Neuroparacoccidioidomycosis; Cerebrospinal fluid; Paracoccidioides brasiliensis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200002

Central venous catheter-related bloodstream infection and Cryptococcus neoformans
Provedor de dados: 55
Autores: Tuon,Felipe F.; Morales,Hugo M. P.; Penteado-Filho,Sergio R.; da-Silva,Margarete M.; Quadros,Isabel de; El Hamoui,Amina.
This is the first case reported of central venous catheter-related fungemia due to C. neoformans. A patient with chronic renal failure developed a fungemia during the treatment of a dialysis-associated bacteremia. Cryptococcus neoformans grew in the catheter tip and blood culture. We addressed questions about this catheter-related fungemia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcus neoformans; Fungemia; Central venous catheter.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400016

Central venous catheter-related bloodstream infection caused by Staphylococcus aureus: microbiology and risk factors
Provedor de dados: 55
Autores: Sadoyma,Geraldo; Diogo Filho,Augusto; Gontijo Filho,Paulo Pinto.
Although central vascular catheters (CVC) are indispensable in modern medicine, they are an important risk factor for primary bacteremias. We examined the incidence and risk factors associated with catheter-related bloodstream infection (CR-BSI) caused by Staphylococcus aureus in surgical patients. A prospective study was carried out in the Hospital das Clínicas da Universidade Federal de Uberlândia (HC-UFU) from September 2000 to December 2002. The skin insertion site, catheter tip, and blood were microbiologically analyzed. Demographics and risk factors were recorded for each patient, and cultures were identified phenotypically. Staphylococcus aureus was the most frequent pathogen, with an incidence rate of 4.9 episodes of CR-BSIs per 1,000...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Ventral venous catheter; Bloodstream infection.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200006

Central venous catheter-related infections caused by Corynebacterium amycolatum and other multiresistant non-diphtherial corynebacteria in paediatric oncology patients
Provedor de dados: 55
Autores: Carvalho,Ricardo Vianna de; Lima,Fernanda Ferreira da Silva; Santos,Cíntia Silva dos; Souza,Mônica Cristina de; Silva,Rondinele Santos da; Mattos-Guaraldi,Ana Luiza de.
ABSTRACT Bloodstream and venous catheter-related corynebacterial infections in paediatric patients with haematological cancer were investigated from January 2003 to December 2014 at the Brazilian National Cancer Institute in Rio de Janeiro, Brazil. We observed that during cancer treatment, invasive corynebacterial infections occurred independent of certain factors, such as age and gender, underlying diseases and neutropenia. These infections were ssscaused by Corynebacterium amycolatum and other non-diphtherial corynebacteria. All cases presented a variable profile of susceptibility to antimicrobial agents, except to vancomycin. Targeted antibiotic therapy may contribute to catheters maintenance and support quality of treatment. Non-diphtherial...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: C. amycolatum; Venouscatheter; Paediatric cancer; Bloodstream infection; Non-diphtherial corynebacteria infection.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400347

Cerebral aspergillosis presenting as a mass lesion
Provedor de dados: 55
Autores: Azarpira,Negar; Esfandiari,Majid; Bagheri,Mohamad Hadi; Rakei,Sed; Salari,Soheila.
Fungal infections of the central nervous system (CNS) are almost always a surprising finding. Their presentation is usually subtle, often without any diagnostic characteristics, and they are frequently mistaken for pyogenic abscesses, or brain tumors. Aspergillosis of the central nervous system is an uncommon infection, mainly occurring in immunocompromised patients. It may present in several forms, including meningitis, mycotic aneurysms, infarcts and a tumoral form. We report an intracranial granuloma due to Aspergillus fumigatus involving the anterior cranial fossa and the frontal lobe. The clinical symptoms began one year before admission. Final diagnosis was made after craniotomy. The patient was treated with an extensive excision of the cerebral mass...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Granulomatous inflammation; Aspergillus fumigatus; Fungal infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400019

Cerebral infarction related to cryptococcal meningitis in an HIV-infected patient: case report and literature review
Provedor de dados: 55
Autores: Leite,Andréa Gurgel Batista; Vidal,José E.; Bonasser Filho,Francisco; Nogueira,Roberta Schiavon; Oliveira,Augusto César Penalva de.
Neurological dysfunction as the first manifestation of AIDS has been found in 10 to 20% of symptomatic human immunodeficiency virus infections. However, stroke has rarely been reported in AIDS patients. The most common causes of cerebral infarction in AIDS are central nervous system infections: toxoplasmosis, cryptococcal meningitis and tuberculosis. Potential vascular mechanisms for cerebral infarction and transient neurological deficits among AIDS patients include deposition of antigen-antibody complexes with vasculitis and infarction, and a direct toxic effect of a viral antigen or infectious agent on vascular endothelium. The role of cryptococcal meningitis in vasculopathy is still not clear. We report a case of cerebral infarction in an HIV-infected...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; Cerebral infarction; Stroke; Cryptococcal meningitis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200008

Cervical cancer and HIV: the Bahia/Brazil situation
Provedor de dados: 55
Autores: Queiroz,Conceição.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500016

Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil
Provedor de dados: 55
Autores: Coser,Janaina; Boeira,Thaís da Rocha; Wolf,Jonas Michel; Cerbaro,Kamila; Simon,Daniel; Lunge,Vagner Ricardo.
Abstract Human papillomavirus (HPV) infection is common in sexually active women and viral persistence may cause intraepithelial lesions and eventually progress to cervical cancer (CC). The present study aimed to investigate epidemiological factors related to HPV infection and to evaluate viral persistence and CC precursor lesions frequencies in women from a city in the countryside of South Brazil. Three hundred women were recruited from a primary public health care clinic. The patients were interviewed and underwent sampling with cervical brushes for HPV-DNA detection/typing by a PCR-based assay and cytological analysis by Pap smear test. HPV was detected in 47 (15.7%) women. HPV infection was significantly associated with young age (&lt;30 years) and low...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV prevalence; HPV persistence; Cervical cancer; Epidemiology.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100061

Cervical spondylitis and spinal abscess due to Actinomyces meyeri
Provedor de dados: 55
Autores: Duvignaud,Alexandre; Ribeiro,Emmanuel; Moynet,Daniel; Longy-Boursier,Maïté; Malvy,Denis.
Human actinomycosis with involvement of the spine is a rare condition although it has been first described a long time ago. It is probably underrecognized since its clinical presentation is often misleading and accurate bacteriological diagnosis is challenging. We herein report a rare case of cervical actinomycosis with paravertebral abscess and spondylitis imputed to an infection by Actinomyces meyeri in a 52-year-old immunocompetent Caucasian man. A. meyeri should be considered as a potential cause for subacute or chronic spondylitis, even in immunocompetent subjects. Modern diagnostic tools such as Matrix-Assisted Laser Desorption–Ionization Time of Flight mass spectrometry and 16S rRNA sequencing are efficient for accurate microbiological identification.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Actinomyces; Spondylitis; MALDI–TOF mass spectrometry; 16S rRNA.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100106

Challenges in the development of drugs for the treatment of tuberculosis
Provedor de dados: 55
Autores: Shehzad,Adeeb; Rehman,Gauhar; Ul-Islam,Mazhar; Khattak,Waleed Ahmad; Lee,Young Sup.
Tuberculosis infection is a serious human health threat and the early 21st century has seen a remarkable increase in global tuberculosis activity. The pathogen responsible for tuberculosis is Mycobacterium tuberculosis, which adopts diverse strategies in order to survive in a variety of host lesions. These survival mechanisms make the pathogen resistant to currently available drugs, a major contributing factor in the failure to control the spread of tuberculosis. Multiple drugs are available for clinical use and several potential compounds are being screened, synthesized, or evaluated in preclinical or clinical studies. Lasting and effective achievements in the development of anti-tuberculosis drugs will depend largely on the proper understanding of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Drug resistance; Tuberculosis; Pathogen.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100012

Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodiagnostic potential
Provedor de dados: 55
Autores: Chaves,Alexandre Silva; Rodrigues,Michele Fernandes; Mattos,Ana Márcia Menezes; Teixeira,Henrique Couto.
ABSTRACT Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important systems of host-pathogen interaction. This genetic mechanism allows the mycobacteria to persist during long time periods, establishing the so-called latent infection. Even in the presence of a competent immune response, the host cannot eliminate the pathogen, only managing to keep it surrounded by an unfavorable microenvironment for its growth....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Latency; DosR antigens; Diagnosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600636

Changes health-related quality of life in HIV-infected patients following initiation of antiretroviral therapy: a longitudinal study
Provedor de dados: 55
Autores: Dutra,Brenda Soares; Lédo,Ana Paula; Lins-Kusterer,Liliane; Luz,Estela; Prieto,Indira Rodriguez; Brites,Carlos.
Abstract  Background: Several tools have been developed to evaluate HIV health-related quality of life (HRQoL) during and after antiretroviral therapy (ART). Few longitudinal studies evaluated the effect of ART on the quality of life of HIV patients.  Objective: To evaluate changes in HRQoL in HIV-infected individuals one year after initiating ART.  Methods: A prospective study was conducted from May 2016 to July 2018. Data on clinical and sociodemographic characteristics of 91 HIV-infected patients were collected prior to initiation of ART and one year thereafter. Demographic and clinical data were collected and the questionnaires 36-item Short Form Health Survey (SF-36) and HIV/AIDS-targeted quality of life (HAT-QoL) were administered in both periods....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Health-related quality of life; Antiretroviral Therapy; HIV; Patient Reported Outcome Measures.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400211

Changes in Staphylococcus aureus susceptibility across Latin America between 2004 and 2010
Provedor de dados: 55
Autores: Garza-González,Elvira; Dowzicky,Michael Joseph.
The Tigecycline Evaluation and Surveillance Trial is a global surveillance study monitoring the efficacy of tigecycline and comparators against clinically important pathogens. Between 2004 and 2010, 3126 isolates of Staphylococcus aureus were collected from 66 centers in 13 countries in Latin America; of these, 1467 (46.9%) were resistant to methicillin. The main contributors of S. aureus isolates were Mexico (n = 846), Argentina (n = 740), and Colombia (n = 445). The methicillin-resistant S. aureus rate was greater than 50% in five countries, the highest reported in Puerto Rico (73.9%). Methicillin-resistant S. aureus rates across Latin America ranged from 40.1% to 50.6% over the study period. All S. aureus isolates were susceptible to linezolid and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tigecycline; Antimicrobial surveillance; Latin America; Staphylococcus aureus.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100003

Changing patterns of AIDS: impact on the indications and diagnostic yield of bone marrow biopsies
Provedor de dados: 55
Autores: Morais,José Carlos; Machado,Marcel; Biasoli,Irene; Barroso,Paulo Feijó; Milito,Cristiane; Spector,Nelson.
After the advent of HAART, the clinical course of HIV infection has dramatically improved. Therefore, it seems appropriate to reevaluate the performance of bone marrow biopsy (BMB) as a diagnostic tool. The aim of the present study was to compare the reasons for performing a BMB and its diagnostic yield in HIV-patients before and after HAART. A total of 165 BMB specimens obtained from HIV-infected patients receiving care at the Hospital of Universidade Federal do Rio de Janeiro in two different periods (1986-1994 and 1999-2004) were analysed. The main reason for BMB examination in the first period was fever (88%), which decreased in the second period (57%, p &lt; 0.0001), when cytopenia (51%) was the leading reason for BMB, whereas in the first period it...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bone marrow biopsy; HIV; HAART.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400019

Changing the face of fever of unknown origin in Egypt: a single hospital study
Provedor de dados: 55
Autores: Montasser,Mohammed Fawzy; Abdelkader,Nadia Abdelaaty; Montasser,Iman Fawzy; Khouly,Ahmed Mahmoud El.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300334

Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi
Provedor de dados: 55
Autores: Matlani,Monika; Chakravarti,Anita.
Tipo: Info:eu-repo/semantics/article
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200019

Characteristic profile of antibody responses to PPD, ESAT-6, and CFP-10 of Mycobacterium tuberculosis in pulmonary tuberculosis suspected cases in Surabaya, Indonesia
Provedor de dados: 55
Autores: Dewi,Desak Nyoman Surya Suameitria; Mertaniasih,Ni Made; Soedarsono,; Ozeki,Yuriko; Artama,Wayan Tunas; Fihiruddin,; Niki,Mamiko; Tateishi,Yoshitaka; Ato,Manabu; Matsumoto,Sohkichi.
Abstract Accurate and rapid diagnostic tools are important aspects of managing tuberculosis (TB) cases appropriately. However, the sensitivity and specificity of diagnostic kits based on immune response such as the tuberculin skin test (TST) and interferon gamma release assay (IGRA) are still debated. Thus, the exploration and assessment of specific biomarker-targeted antibodies are needed for the development of an accurate and rapid diagnostic tool. The present study was conducted in patients with a respiratory problem suspected to be TB at Dr. Soetomo Hospital, Surabaya, Indonesia. Among 102 patients tested by GeneXpert and AFB, 59 serum samples were from cases retrospectively determined to have active TB. A total of 102 serum of healthy controls (HC)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibody response' profile; PPD; Pulmonary tuberculosis; NTM.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400246

Characteristics associated with anti-HCV serological markers in prisoners in the state of Paraná, Brazil: a case-control study
Provedor de dados: 55
Autores: Silva,Tânia Maria Pazin Marques; Ferreto,Lirane Elize Defante; Follador,Franciele Ani Caovilla; Vieira,Ana Paula; Yamada,Roberto Shigueyasu; Lucio,Léia Carolina; Titon,Joana Perotta; Torres,Renata Himovski; Amaral,Greicy Cézar do; Coelho,Harnoldo Colares.
ABSTRACT  Background: The prison system in Paraná, Brazil, is experiencing serious problems related to the increasing number of prisoners. Control of hepatitis C virus (HCV) has become more intense because the incarcerated population is considered a high-risk group for contagious diseases due to the favorable conditions found in prisons for the spread of these morbidities. The objective of this study was to identify features associated with hepatitis C infection among male prisoners in correctional institutions of Paraná state, Brazil.  Methods: This was a case-control study (27 cases and 54 controls) of men incarcerated in 11 penitentiaries in Paraná, Brazil. Information was obtained through a questionnaire in a cross-sectional epidemiological survey on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Risk factors; Prisoners.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300173

Characteristics of co-infections by HCV and HBV among Brazilian patients infected by HIV-1 and/or HTLV-1
Provedor de dados: 55
Autores: Moreira,Marcia; Ramos,André; Netto,Eduardo M.; Brites,Carlos.
BACKGROUND: The human retroviruses HIV-1 and HTLV-1 share the routes of infection with hepatitis viruses B and C. Co-infection by these agents are a common event, but we have scarce knowledge on co-infection by two or more of these agents. OBJECTIVE: To evaluate the characteristics and risk factors for co-infections by HBV and HCV in patients infected by HIV-1 or/and HTLV-1, in Salvador, Brazil. METHODS: In a case-control study we evaluated patients followed in the AIDS and HTLV clinics of Federal University of Bahia Hospital. Clinical and epidemiological characteristics were reviewed, and patients were tested for the presence of serological markers of HBV and HCV infections. HCV-infected patients were tested by PCR to evaluate the presence of viremia....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; HTLV-1; Coinfection; HCV; HBV; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600007

Characteristics of gonorrhea and syphilis cases among the Roma ethnic group in Belgrade, Serbia
Provedor de dados: 55
Autores: Bjekić,Milan; Vlajinac,Hristina; Šipetić-Grujičić,Sandra.
Abstract  Background The Roma ethnic group is the largest and most marginalized minority in Europe, believed to be vulnerable to sexually transmitted infections.  Aim The purpose of the study was to investigate frequency and characteristics of gonorrhea and syphilis among the Roma population in Belgrade.  Methods Data from the City Institute for Skin and Venereal Diseases to which all gonorrhea and syphilis cases are referred were analyzed.  Results During the period of 2010–2014 sexually transmitted infections were more frequent among Roma than in rest of Belgrade population. Average percentages of Roma among all reported subjects with syphilis and those with gonorrhea were 9.6% and 13.5%, respectively, while the percentage of Roma in the total Belgrade...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Roma population; Syphilis; Gonorrhea; Serbia.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400349

Characteristics of HIV antiretroviral regimen and treatment adherence
Provedor de dados: 55
Autores: Silveira,Vera Lúcia da; Drachler,Maria de Lourdes; Leite,José Carlos de Carvalho; Pinheiro,Cézar Arthur Tavares.
The relationship between characteristics of HIV antiretroviral regimens and treatment adherence was studied in adolescent and adult patients who underwent antiretroviral therapy from January 1998 to September 2000, at the Service for Specialized Assistance in Pelotas. The patients were interviewed on two occasions, and the use of antiretrovirals during the previous 48 hours was investigated by a self-report. Adherence was defined as use of 95% or more of the prescribed medication. Social-demographic variables were collected through direct questionnaires. The antiretroviral regimen and clinical data were copied from the patients' records. Associations between the independent variables and adherence were analyzed by means of logistic regression. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Adherence; Antiretroviral therapy.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300004

Characteristics of hospitalized children infected with macrolide-resistant Mycoplasma pneumoniae
Provedor de dados: 55
Autores: Komatsu,Haruki; Tsunoda,Tomoyuki; Inui,Ayano; Sogo,Tsuyoshi; Fujisawa,Tomoo.
BACKGROUND: The aim of this study was to clarify retrospectively the characteristics of children hospitalized for respiratory tract infection caused by macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae).METHODS: Children who were hospitalized for respiratory tract infection due to M. pneumoniae were enrolled in this study. The diagnosis of M. pneumoniae infection was made on the grounds of polymerase chain reaction results.RESULTS: Thirty-three children were hospitalized due to lower respiratory tract infection with M. pneumoniae. Of the 33 children, 31 (median age five years) were identified as being infected with macrolide-resistant M. pneumoniae (A2063G:30, A2064G:1) by sequence analysis. Of the 31 children infected with macrolide-resistant M....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Minocycline; Mutation; Young children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300294

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units
Provedor de dados: 55
Autores: Medell,Manuel; Medell,Mariana; Martínez,Alicia; Valdés,Rodolfo.
OBJECTIVE: This observational study described the characterization of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units. The demonstration of isolated microorganism resistance to antibiotics and a time-trend analysis of infection comparing a 48-month period were also other objectives. METHOD: Semi-quantitative assays of 1254 samples taken from 741 ventilated patients were performed, while pathogens were identified using the Enterotube II assay and VITEK 2 Compact equipment. Bacterial resistance to antibiotics was assessed by the Kirby-Bauer disc diffusion method and time-trend analysis of infection was based on data recorded by hospital microbiology laboratories. RESULTS: The most prevalent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-bacterial agents; Respiratory care units; Bronchopneumonia.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100008

Characterization of a small outbreak of Salmonella enterica serovar Infantis that harbour CTX-M-65 in Ecuador
Provedor de dados: 55
Autores: Cartelle Gestal,Monica; Zurita,Jeannete; Paz y Mino,Ariane; Ortega-Paredes,David; Alcocer,Iliana.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400406

Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China
Provedor de dados: 55
Autores: Chen,Jun; Chen,Zhifei; Li,Yuanyuan; Xia,Wei; Chen,Xi; Chen,Tian; Zhou,Liping; Xu,Bin; Xu,Shunqing.
OBJECTIVE: The study aimed to investigate gyrA and gyrB mutations in Mycobacterium tuberculosis (MTB) clinical strains from 93 patients with pulmonary tuberculosis in Hubei Province, China, and analyze the association between mutation patterns of the genes and ofloxacin resistance level. RESULTS: Among 93 MTB clinical isolates, 61 were ofloxacin-resistant by the proportion method, and 32 were ofloxacin-susceptible MDR-TB. No mutation in the gyrB gene was found in any MTB strains. In the 61 ofloxacin-resistant isolates, 54 mutations were observed in the gyrA gene. Only one mutation in the gyrA gene was found in ofloxacin-susceptible MDR-TB isolates. In this study, the mutation patterns of gyrA involved seven patterns of single codon mutation (A90V, S91P,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Fluoroquinolones; DNA mutational analysis.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200005

Characterization of HBeAg-negative chronic hepatitis B in western Brazilian Amazonia
Provedor de dados: 55
Autores: Victoria,Flamir da Silva; Oliveira,Cintia Mara Costa de; Victoria,Marilu Barbieri; Victoria,Cristian Barbieri; Ferreira,Luis Carlos Lima.
The present study was conducted with 55 patients native from western Brazilian Amazonia, who were HBV-DNA positive after seroconversion of HBeAg. It is a descriptive case study, with the patients separated into two groups: with hepatitis and without hepatitis on histological examination. The aim of the present study was to describe the clinical and molecular characteristics of patients who are chronic carriers of HBsAg. The prevalence of hepatitis was 63.64%, with a predominance of males (41.82%) and a mean age of 42.5 years, occurring mostly in natives of the southeast sub-region (32.73%). Time was a variable proportional to the course of the disease and the most frequent symptoms were: dyspepsia, asthenia and loss of libido with the majority of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBeAg-negative chronic hepatitis B; Western Brazilian Amazonia; Mutations.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100008

Characterization of rickettsia rickettsii in a case of Fatal Brazilian spotted fever in the city of Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Lamas,Cristiane; Favacho,Alexsandra; Rozental,Tatiana; Bóia,Márcio N.; Kirsten,Andrei H.; Guterres,Alexandro; Barreira,Jairo; Lemos,Elba Regina S. de.
A lethal case of Brazilian spotted fever (BSF) is presented. Clinical features were initially of gastrointestinal involvement and evolved with progression to septic shock, meningoencephalitis and death on the 6th day of illness. Indirect immunofluorescence assay (IFA) for spotted fever group rickettsia (SFGR) was non-reactive. Diagnosis was confirmed by the polymerase chain reaction (PCR) and the nucleotide sequencing of a fragment of the ompA gene showed 100% homology to Rickettsia rickettsii. BSF has not been reported in the city of Rio de Janeiro in the last three decades, and the present description should alert the clinicians to its presence in urban Rio de Janeiro, and to the differential diagnosis with dengue fever, gastroenteritis, leptospirosis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazilian spotted fever; Spotted fever group rickettsia; Rickettsia rickettsii; Lethal case; Rio de Janeiro city; Indirect immunofluorescence; Polymerase chain reaction; Central nervous system involvement.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200010

Characterization of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil
Provedor de dados: 55
Autores: Oliveira,Geraldo A.; Faria,Juarez B.; Levyand,Carlos E.; Mamizuka,Elsa M.
The objective of this study was to characterize patterns of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil. We studied 83 MRSA strains isolated from patients hospitalized in 27 public and private hospitals in 19 cities located in 14 Brazilian states from September, 1995, to June, 1997. The MRSA strains were typed using antibiograms, bacteriophage typing and pulsed field gel electrophoresis (PFGE). The analysis of genomic DNA by PFGE showed that 65 isolates presented the same PFGE pattern. This pattern was present in all of the hospitals studied indicating the presence of an endemic MRSA clone widely disseminated throughout Brazilian hospitals (BEC). All isolates belonging to the BEC proved...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococus aureus; MRSA; Epidemiology; Brazilian endemic clone.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400001

Characterization of the genetic environment of the bla KPC-2 gene among Klebsiella pneumoniae isolates from a Chinese Hospital
Provedor de dados: 55
Autores: Shen,Pinghua; Zhang,Ying; Li,Gang; Jiang,Xiaofei.
Abstract Infection caused by carbapenem-resistant Klebsiella pneumoniae has become a major healthcare threat and KPC-2 enzyme is a dominant factor mediating carbapenems resistance in K. pneumoniae. This study was designed to determine the genetic environment of bla KPC-2, which prevailed in clinical K. pneumoniae isolates recovered in Huashan Hospital, Shanghai, China. Forty-two clinical isolates were included in this study by bla KPC-2 screening. After multilocus sequence typing and plasmid analyses of PCR-based replicon typing (PBRT), junction PCR, mapping PCR and crossing PCR assays, primer walking, and amplicon sequencing were used to analyze the genetic environment of the bla KPC-2 gene. ST423, ST65, ST977, and ST11 were all detected in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Klebsiella pneumoniae; BlaKPC; Genetic environment.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400384

Characterization of the high-risk human papillomavirus infection in Jining, China
Provedor de dados: 55
Autores: Jia,Yinfeng; Guo,Huan; Liu,Feifei; Zhou,Guangqi; Dong,Haixin; Bi,Ling; Jia,Jialin; Sun,Hui.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200029

Characterization of virologic failure after an initially successful 48-week course of antiretroviral therapy in HIV/AIDS outpatients treated in Santos, Brazil
Provedor de dados: 55
Autores: Caseiro,Marcos M.; Golegã,Alcino A.C.; Etzel,Arnaldo; Diaz,Ricardo Sobhie.
We characterized the virologic failure after an initially successful 48-week course of antiretroviral therapy among HIV/AIDS patients in a retrospective cohort study involving patients from Santos, Brazil. Patients with plasma HIV RNA below 500 copies/mL for 48 weeks were included. Variables analyzed included gender, age, level of education, marital status, mode of HIV acquisition, viral load, and CD4 cell count upon admission. There were 4,909 patients registered with the clinic, of which 669 patients met all the inclusion criteria (41.6% female and 58.4% male). Only 27.5% of the patients maintained undetectable viral loads during up to one year of follow-up. After 48 weeks, virologic failure occurred earlier in females and in patients first treated with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Virologic failure; HIV; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300001

Chest radiograph abnormalities in patients hospitalized with leptospirosis in the city of Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Matos,Eliana Dias; Costa,Everaldo; Sacramento,Edilson; Caymmi,Anna Luiza; Araújo Neto,César de; Lopes,Marcelo Barreto; Lopes,Antonio Alberto.
This study was designed to estimate the prevalence of pulmonary radiograph abnormalities and describe the distribution of the patterns of radiographic alterations among patients hospitalized with leptospirosis. Chest radiographs of 139 patients hospitalized with leptospirosis in Couto Maia Hospital, in Salvador, Bahia, Brazil, between July, 1997, and July, 1999, were analyzed. The radiographs were requested soon after hospital admission, independent of the clinical manifestations of the patients. Only the first radiograph was considered. Pulmonary radiograph alterations were recorded in 35/139 patients (25.2%); 95% mid-point confidence interval = 18.5% to 32.9%. Among the patients with radiograph alterations, alveolar infiltrate was seen in 26/35 (74.3%)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Chest radiography.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200005

Chikungunya: bending over the Americas and the rest of the world
Provedor de dados: 55
Autores: Madariaga,Miguel; Ticona,Eduardo; Resurrecion,Cristhian.
Abstract Chikungunya is an arthropod-borne virus transmitted by Aedes mosquito bites. A viral mutation has allowed Aedes albopictus to become the preferred vector extending the geographic spread of the condition. The virus causes an acute febrile illness occasionally followed by a chronic rheumatic condition causing severe impairment. The diagnosis is usually confirmed with serology. No specific treatment is currently available. This article reviews the condition with emphasis on his dissemination in the Americas.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chikungunya; Alphavirus; Epidemics.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100091

Childhood pneumonia: clinical aspects associated with hospitalization or death
Provedor de dados: 55
Autores: Nascimento-Carvalho,Cristiana M.C.; Rocha,Heonir; Santos-Jesus,Rogério; Benguigui,Yehuda.
OBJECTIVE: To determine which available information at an Emergency Room (ER) consultation is associated with hospitalization or death among children with pneumonia. DESIGN: Prospective cohort study. SETTING: The ER of one university and one private hospital. MEASUREMENT: Using stepwise logistic regression we analyzed factors that showed a univariate association. MAIN RESULTS: Of 2,970 cases, the median age was 1.83 years (range 2 days to 14.5 yrs, mean 2.76 + 2.72 yrs); 25.8% were hospitalized and 0.8% died. Age (2-11 mos, OR 0.4 [0.2-0.6]; 12-59 mos, OR 0.2 [0.1-0.4]; &lt;FONT FACE=Symbol&gt;³&lt;/FONT&gt; 5yrs, OR 0.1 [0.08-0.3]), malnutrition (OR 2.0 [1.4-2.7]), underlying chronic illness (OR 1.4 [1.1-1.8]), tachypnea (OR 1.8 [1.4-2.4]), chest...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Children; Clinical signs; Hospitalization; Mortality; Outpatients.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100004

Childhood respiratory viruses in public health care centers
Provedor de dados: 55
Autores: Bonati,Poliana Castro de Resende; Silva,Carlos Henrique Martins da.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200022

Chinese pregnant women in their third trimester are more susceptible to HEV infection
Provedor de dados: 55
Autores: Huang,Fen; Wang,Jue; Yang,Chenchen; Long,Feiyan; Li,Yunlong; Li,Li; Jing,Shenrong; Wang,Huixuan.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600672

Chlamydia infection in patients with and without cervical intra-epithelial lesions tested by real-time PCR vs. direct immunofluorescence
Provedor de dados: 55
Autores: Oliveira,Micheline de Lucena; Amorim,Melania Maria Ramos de; Souza,Paulo Roberto Eleutério de; Albuquerque,Lúcia Cristina Bezerra de; Brandão,Lucas André Cavalcanti; Guimarães,Rafael Lima.
This study compares the detection rates of Chlamydia trachomatis by two techniques, direct immunofluorescence (IMF) and real time polymerase chain reaction (PCR), in patients with and without intra-epithelial cervical lesions (SIL) in Recife. We conducted a transversal study involving 35 women with SIL and 35 without SIL attended at Ambulatório Especializado da Mulher, Recife, Brazil. They were tested for Chlamydia trachomatis using two techniques, direct IMF or real time PCR. The rates of Chlamydia trachomatis detection were compared and the association with intra-epithelial cervical lesions was determined using the chi-square test at a 5% level of significance. Concordance between the tests was evaluated using kappa. The global prevalence of Chlamydia...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Chlamydia infections; Fluorescent antibody technique direct; Polymerase chain reaction.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400014

Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesions
Provedor de dados: 55
Autores: Calil,Luciane Noal; Igansi,Cristine Nascente; Meurer,Luise; Edelweiss,Maria Isabel Albano; Bozzetti,Mary Clarisse.
The objective of this study was to identify the frequency of coinfection by human papillomavirus (HPV) and Chlamydia trachomatis (CT) in cervical lesions and relate it with immunohistochemical expression of p16INK4a and Ki67, both oncogenicity markers. A cross-sectional study with 86 women from primary care units in southern Brazil was conducted. Cervical swabs were collected for HPV-DNA and CT-DNA detection, through the polymerase chain reaction technique (PCR). The immunohistochemical analysis was performed on biopsy cervical tissue material to identify the expression of p16INK4a and Ki67 cell cycle markers. About 83 % were positive for HPV-DNA and 19% had coinfection with CT-DNA. Among coinfected women, 56% expressed p16INK4a. There was a statistically...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Human papillomavirus 16; Biomarkers; Pharmacological.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200006

Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina
Provedor de dados: 55
Autores: Deluca,Gerardo Daniel; Basiletti,Jorge; Schelover,Eduardo; Vásquez,Nicolás Díaz; Alonso,José Mario; Marín,Héctor Marcelo; Lucero,Raúl Horacio; Picconi,María Alejandra.
Objectives: High-risk types of human papillomavirus (HPV) are strongly associated with cervical cancer (CC), and Chlamydia trachomatis (CT), the most frequent sexually transmitted bacterial infection (STBI) worldwide, seems to be a risk factor for HPV infection and for CC. It is also known that both agents are more prevalent in vulnerable communities where lack of adequate primary health care is a cause for concern. The aim of this work was to determine the impact of CT and HPV infections in women belonging to an isolated aboriginal population (Pilaga community) from a poor region in Northern Argentina (province of Formosa). For this purpose, a cross-sectional study was performed in all sexually active Pilaga women, who attended a local community-based...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Papillomavirus infections; Indigenous population; Uterine cervical diseases.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600011

Chlamydia trachomatis in human immunodeficiency virus-infected men treated at a referral hospital for sexually transmitted diseases in the Amazonas, Brazil☆
Provedor de dados: 55
Autores: Jalkh,Alex Panizza; Miranda,Angelica Espinosa; Hurtado-Guerreiro,Jose Camilo; Ramos,Lorena Angelica Castano; Figliuolo,Guiseppe; Maia,Jussimara; Costa,Cintia Mara; Ramasawmy,Rajendranath; Ferreira,Luiz Carlos de Lima.
OBJECTIVES:The aim of the present study was to determine the Chlamydia trachomatis prevalence and to identify the demographic, behavioural and clinical factors associated with C. trachomatis in human immunodeficiency virus infected men.STUDY:This was a cross-sectional study of C. trachomatis prevalence among human immunodeficiency virus-infected men enrolled at the Outpatient clinic of acquired immunodeficiency syndrome of the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado in Manaus, Amazonas, Brazil. C. trachomatis deoxyribonucleic acid from urethral samples was purified and submitted to real time polymerase chain reaction to identify the presence of C. trachomatis.RESULTS:A total of 276 human immunodeficiency virus-infected men were included in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Real-time polymerase chain reaction (RT-PCR); HIV-infected men; Amazonas.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200158

Chlamydia trachomatis infection among HIV-infected women attending an AIDS clinic in the city of Manaus, Brazil
Provedor de dados: 55
Autores: Silva,Leila Cristina Ferreira; Miranda,Angélica Espinosa; Batalha,Rosieny Santos; Sabino,Carolina; Dib,Elizabeth Cristina Dantas; Costa,Carolina Marinho da; Ramasawmy,Rajendranath; Talhari,Sinésio.
This was a cross-sectional study aimed to determine the prevalence of and to identify risk factors for Chlamydia trachomatis (CT) among human immunodeficiency virus (HIV)-infected women attending the acquired immunodeficiency syndrome (AIDS) clinic in the city of Manaus, Brazil, in 2009-2010. Participants answered a questionnaire containing demographic, epidemiological, and clinical data. A genital specimen was collected during examination to detect CT-DNA by hybrid capture, and blood samples were taken to determine CD4+T and HIV viral load. There were 329 women included in the study. Median age was 32 years (IQR = 27-38) and median schooling was nine years (IQR = 4-11). The prevalence of CT was 4.3% (95%CI: 2.1-6.5). Logistic regression analysis showed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; HIV; Women; Amazonas.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400004

Chlamydia trachomatis infection in a sample of northern Brazilian pregnant women: prevalence and prenatal importance
Provedor de dados: 55
Autores: Borborema-Alfaia,Ana Paula B. de; Freitas,Norma Suely de Lima; Astolfi Filho,Spartaco; Borborema-Santos,Cristina Maria.
There are limited data regarding prevalence of Chlamydia trachomatis infection among northern Brazilian pregnant women. OBJECTIVE: The purpose of this study was to estimate the prevalence of chlamydial infection among pregnant women in their third trimester and to determine the repercussion of this infection on their offspring. METHODS: In the first phase of this study 100 pregnant women receiving prenatal care in a local public university hospital were examined to assess the prevalence of genital C. trachomatis infection by polymerase chain reaction technique. In the second phase, 88 pregnant women were prospectively evaluated for premature rupture of membranes, puerperal consequences associated with chlamydial infection, and neonates were checked for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Pregnant women; Neonatal infection; Respiratory symptoms; Polymerase chain reaction; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500006

Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles
Provedor de dados: 55
Autores: Shinde,Ravikumar Bapurao; Raut,Jayant Shankar; Chauhan,Nitin Mahendra; Karuppayil,Sankunny Mohan.
Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal; Biofilm; Candida albicans; Combination; Chloroquine; Drug resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400002

Chronic hepatitis C and fibrosis: evidences for possible estrogen benefits
Provedor de dados: 55
Autores: Codes,Liana; Matos,Ludmilla; Paraná,Raymundo.
The main injury caused by hepatitis C virus is the hepatic fibrosis, as a result of a chronic inflammatory process in the liver characterized by the deposit of components from the extracellular matrix. The fibrosis development leads to the modification of the hepatic architecture, of the hepatocellular function and to irregularities in the microcirculation. The tissue remodeling process observed in fibrosis has stellate cells, located at the space of Disse, as main acting agents. These cells, in response to a harmful stimulus, undergo phenotypic changes from non-proliferating cells to proliferating cells that express a- smooth-muscle actin (a-SMA), a process called as transdifferentiation. There are evidences that the oxidative stress is involved in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Fibrosis; Estrogen; Benefits.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300014

Chronic hepatitis C: pathological anatomy
Provedor de dados: 55
Autores: Mello,Evandro Sobroza de; Alves,Venâncio Avancini Ferreira.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700010

Chronic hepatitis C virus in the state of Piauí, northeastern Brazil
Provedor de dados: 55
Autores: Veras,Kelson Nobre; Jacobina,Kelson Sousa; Soares,Vítor Y. Rocha; Avelino,Marcela Amaral; Vasconcelos,Conceição de Maria S.R.; Parente,José Miguel L.
Knowledge of genotype distribution of hepatitis C virus (HCV) has clinical importance due to genotype 1 lower response to treatment compared with genotypes 2 and 3. The goal of this survey was to describe clinical and laboratorial profiles of patients with chronic hepatitis C (CHC) in the State of Piauí, as well as to expand the overall awareness of the distribution of HCV genotyping in Northeast of Brazil. A retrospective cross-sectional study was carried out between April 1999 and August 2005. A total of 153 patients were included, 119 (77.8%) males and 34 (22.2%) females; mean age = 48.01 ± 9.11 years. We observed a homogeneous distribution between genotypes 1 (50.0%) and 3 (49.0%), while the most frequent subtype noticed was 3a (49.0%). The mean viral...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Hepatitis C virus; Genotype distribution; Chronic hepatitis C.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200011

Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia
Provedor de dados: 55
Autores: Pereira,G.H.; Pádua,S.S.; Park,M.V.F.; Muller,R.P.; Passos,R.M.A.; Menezes,Y.
Meningitis is a common evolution in progressive disseminated histoplasmosis in children, and is asymptomatic in many cases. In leukemia, the impaired of the T cells function can predispose to the disseminated form. The attributed mortality rate in this case is 20%-40% and the relapse rate is as high as 50%; therefore, prolonged treatment may be emphasized. We have described a child with acute myeloid leukemia (AML), that developed skin lesions and asymptomatic chronic meningitis, with a good evolution after prolonged treatment with amphotericin B deoxycholate followed by fluconazole.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histoplamosis; Chronic meningitis; Antifungal therapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600026

Chronic pelvic pain due to Mycobacterium parascrofulaceum in an Iranian patient: first report of isolation and molecular characterization from Asia
Provedor de dados: 55
Autores: Shojaei,Hasan; Hashemi,Abdolrazagh; Heidarieh,Parvin; Daei-Naser,Abass.
Tipo: Info:eu-repo/semantics/article
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200020

Chronic pulmonary paracoccidioidomycosis in an AIDS patient and Mycobacterium gordonae as confounding factor
Provedor de dados: 55
Autores: Miranda,Érique José Peixoto de; Gonçalves,Luiz Guilherme; França,Francisco Oscar de Siqueira.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100019

Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient
Provedor de dados: 55
Autores: Adiwardana,Natanael Sutikno; Morás,Juliana de Angelo; Bernardo,Leandro Lombo; Klautau,Giselle Burlamaqui; Queiroz,Wladimir; Vidal,Jose Ernesto.
ABSTRACT Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. He was submitted to an excisional biopsy of the lesion but no etiological diagnosis was identified. After this procedure, the post-surgical wound never completely healed. At admission, the patient presented nausea and headache for three days and an open orifice into his skull. Investigations confirmed meningitis and skull osteomyelitis caused by Cryptococcus neoformans. He was treated with...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcus neoformans; Osteomyelitis; Skull; HIV.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600499

Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients
Provedor de dados: 55
Autores: Nihues,Simone de Sousa Elias; Mancuzo,Eliane Viana; Sulmonetti,Nara; Sacchi,Flávia Patussi Correia; Viana,Vanessa de Souza; Martins Netto,Eduardo; Miranda,Silvana Spindola; Croda,Julio.
ABSTRACTBACKGROUND: Questionnaire and spirometry were applied to post-tuberculosis indigenous and non-indigenous individuals from Dourados, Brazil, to investigate the prevalence of chronic respiratory symptoms and pulmonary dysfunction.METHODS:This was a cross-sectional study in cured tuberculosis individuals as reported in the National System on Reportable Diseases (SINAN) from 2002 to 2012.RESULTS:One hundred and twenty individuals were included in the study and the prevalence of chronic respiratory symptoms was 45% (95% CI, 34-59%). Respiratory symptoms included cough (28%), sputum (23%), wheezing (22%) and dyspnea (8%). These symptoms were associated with alcoholism, AOR: 3.1 (1.2-8.4); less than 4 years of schooling, AOR: 5.0 (1.4-17.7); and previous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; Dysfunction; Spirometry; Tuberculosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500492

Chronic ulcers and myasis as ports of entry for Clostridium tetani
Provedor de dados: 55
Autores: Greco,Jiuseppe Benitivoglio; Sacramento,Edilson; Tavares-Neto,José.
Evaluating tetanus immune status is not yet the usual clinical practice regarding patients with chronic ulcers or myasis. However, of 858 tetanus patients at Hospital Couto Maia (Salvador, Bahia, Brazil) aged 1 year or above, 2 had pressure ulcers and 17 had chronic ulceration of the lower limbs where these skin lesions were the ports of entry for Clostridium tetani. In these 19 cases, the following predisposing factors were described: venous insufficiency (n=6), sickle cell anemia (n=2), Hansen's disease (n=1), malnutrition (n=1), diabetes mellitus (n=1), trauma (n=1) and unknown factors (n=7). In 6 other cases, in addition to the Hansen's disease patient, the port of entry for tetanus was the site of extraction of Tunga penetrans larvae. In these 25...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tetanus; Chronic leg ulcer; Venous leg ulcer; Sickle cell disease; Hansen's disease; Tunga penetrans; Clostridium tetani.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600005

Ciguatera fish poisoning in Brazilian traveler to Caribbean
Provedor de dados: 55
Autores: Neves Junior,Cidney K.; Goldani,Luciano Z.
ABSTRACT Ciguatera poisoning is the most common form of non-bacterial food-poisoning from fish worldwide. The incidence among Brazilians returning from high-risk regions is unclear because it is not a mandatory reportable disease. We describe a previously healthy 53-year-old Brazilian woman developed Ciguatera fish poisoning while traveling to Havana, Cuba. Physicians and health care professionals should advise travelers to avoid eating ciguatoxic fish species and potentially toxic fish species in the Caribbean islands. Despite the prognosis for most cases is good with a short duration of self-limited symptoms, early recognition of the identifying clinical features of ciguatera can result in improved patient care.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Ciguatera; Caribbean; Brazilian traveller; Fish poisoning.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300200

Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection
Provedor de dados: 55
Autores: Galvão-Lima,Leonardo J.; Espíndola,Milena S.; Soares,Luana S.; Zambuzi,Fabiana A.; Cacemiro,Maira; Fontanari,Caroline; Bollela,Valdes R.; Frantz,Fabiani G.
Abstract  Objectives: Three decades after HIV recognition and its association with AIDS development, many advances have emerged – especially related to prevention and treatment. Undoubtedly, the development of Highly Active Antiretroviral Therapy (HAART) dramatically changed the future of the syndrome that we know today. In the present study, we evaluate the impact of Highly Active Antiretroviral Therapy on macrophage function and its relevance to HIV pathogenesis.  Methods: PBMCs were isolated from blood samples and monocytes (CD14+ cells) were purified. Monocyte-Derived Macrophages (MDMs) were activated on classical (MGM-CSF+IFN-γ) or alternative (MIL-4+IL13) patterns using human recombinant cytokines for six days. After this period, Monocyte-Derived...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Innate immune response; HAART; Macrophages.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100042

Classification of journals in the QUALIS System of CAPES: the urgent need for changing the criteria
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200001

Clinical and bacteriological characteristics of invasive pneumococcal disease after pneumococcal 10-valent conjugate vaccine implementation in Salvador, Brazil
Provedor de dados: 55
Autores: Leite,Carolina Regis; Azevedo,Jailton; Galvão,Vivian Santos; Moreno-Carvalho,Otávio; Reis,Joice Neves; Nascimento-Carvalho,Cristiana.
Abstract Invasive pneumococcal disease is a relevant public health problem in Brazil, especially among children and the elderly. In July/2010 a 10-valent pneumococcal conjugate vaccine was introduced to the immunization schedule of Brazilian children under two years of age. Between July/2010 and December/2013 we conducted a case-series study on invasive pneumococcal disease in Salvador, Brazil to describe the clinical and bacteriological profile of invasive pneumococcal disease cases during the post-implementation period. Eighty-two cases were eligible. Mean age was 31 years (interquartile range, 3–42); 17.1% and 30.5% were under 2 years and 5 years, respectively. Pneumococcal meningitis (n = 64, 78.1%), bacteraemic pneumococcal pneumonia (n = 12, 14.6%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Vaccine; Epidemiology.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100056

Clinical and biochemical evaluation of HIV-related lipodystrophy in an ambulatory population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
Provedor de dados: 55
Autores: Monnerat,Bruno Zanotelli; Cerutti Junior,Crispim; Caniçali,Sheila Cristina; Motta,Tânia Reuter.
We designed a retrospective cohort study to identify factors associated with HIV-1 related lipodystrophy at a tertiary HIV-care center in Vitória, ES, Brazil. Inclusion criteria were documented HIV diagnosis, anti-retroviral therapy and age above 17 years. Highly active antiretroviral therapy (HAART) was initially the exposure variable, but a second analysis was also performed, as a nested case-control, based on the presence or absence of lipodystrophy. Use of protease inhibitors (PI) was associated with an increase in serum triglycerides (243.7 ± 189 mg/dL vs. 172.7 ± 131 mg/dL, p = 0.015), but not of total cholesterol (TC) or HDL fraction levels. Non-nucleoside reverse transcriptase inhibitors (NNRTI) were associated with an increase in serum TC (180.6 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipodystrophy; Dyslipidemia; Brazil; AIDS; ARV therapy; Cohort study.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400002

Clinical and economic impact of generic versus brand name meropenem use in an intensive care unit in Colombia
Provedor de dados: 55
Autores: Ordóñez,Karen; Feinstein,Max M.; Reyes,Sergio; Hernández-Gómez,Cristhian; Pallares,Christian; Villegas,María V.
Abstract  Background: Recent studies suggest that sustained use of generic antibiotics may be associated with clinical failure and emergence of antibacterial resistance. The present study was designed to determine the clinical outcome between the use of generic meropenem (GM) and brand-name meropenem (BNM). Additionally, this study evaluated the economic impact of GM and BNM to determine if the former represents a cost-effective alternative to the latter.  Methods: Patients treated between January 2011 and May 2014 received GM while patients treated between June 2014 and March 2017 received BNM. Mortality was compared between groups. Total infection cost was defined by the cost of antimicrobial consumption, length of stay, and laboratory and imaging exams...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Generic drugs; Meropenem; Mortality; Costs; Critical care; Gram negative bacteria.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400237

Clinical and epidemiological aspects of children hospitalized with severe rotavirus-associated gastroenteritis in Salvador, BA, Brazil
Provedor de dados: 55
Autores: Carneiro,Nadya B.; Diniz-Santos,Daniel R.; Fagundes,Sabrina Q.; Neves,Lívio L.; Reges,Rodrigo M. B.; Lima,Eduardo K. P.; Quadros,Vitor H. de Oliva; Soares,Luis E. de Jesus; Silva,Fernando S. R.; Schneiter,Henrique de Gouvêa; Figueiredo,Ísis; Silva,Luciana R.
Little is known about the epidemiology of severe rotavirus-associated gastroenteritis in Brazil. Given the morbidity associated with this condition and the importance of having detailed knowledge about the impact of rotavirus infection on the epidemiology of acute diarrhea in children, especially those with the most severe diarrheal conditions, we retrospectively reviewed the medical records of all pediatric patients admitted to a tertiary hospital in Salvador, Brazil, due to rotavirus-associated gastroenteritis during one year. It was observed that rotavirus was responsible for 15.6% of the hospitalizations caused by diarrhea and/or vomiting during the period of the study and that 87 of 218 (39.1%) patients seen at the emergency room with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; Acute diarrhea; Epidemiology; Children.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600013

Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia
Provedor de dados: 55
Autores: Cortés,Jorge Alberto; Reyes,Patricia; Gómez,Carlos Hernando; Cuervo,Sonia Isabel; Rivas,Pilar; Casas,Christian A.; Sánchez,Ricardo.
Background:Bloodstream infection by Candida species has a high mortality in Latin American countries. The aim of this study was to describe the characteristics of patients with documented bloodstream infections caused by Candida species in third level hospitals and determine the risk factors for in-hospital-mortality.Methods:Patients from seven tertiary-care hospitals in Bogotá, Colombia, with isolation of a Candida species from a blood culture were followed prospectively from March 2008 to March 2009. Epidemiologic information, risk factors, and mortality were prospectively collected. Isolates were sent to a reference center, and fluconazole susceptibility was tested by agar-based E-test. The results of susceptibility were compared by using 2008 and 2012...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Candidemia; Candidemia/epidemiology; Candidemia/mortality; Candidemia/therapy; Colombia; Fluconazole.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600631

Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis
Provedor de dados: 55
Autores: Prado,Thiago Nascimento do; Rajan,Jayant V.; Miranda,Angélica Espinosa; Dias,Elias dos Santos; Cosme,Lorrayne Beliqui; Possuelo,Lia Gonçalves; Sanchez,Mauro N.; Golub,Jonathan E.; Riley,Lee W.; Maciel,Ethel Leonor.
Abstract  Background: TB patients co-infected with HIV have worse treatment outcomes than non-coinfected patients. How clinical characteristics of TB and socioeconomic characteristics influence these outcomes is poorly understood. Here, we use polytomous regression analysis to identify clinical and epidemiological characteristics associated with unfavorable treatment outcomes among TB-HIV co-infected patients in Brazil.  Methods: TB-HIV cases reported in the Brazilian information system (SINAN) between January 1, 2001 and December 31, 2011 were identified and categorized by TB treatment outcome (cure, default, death, and development of MDR TB). We modeled treatment outcome as a function of clinical characteristics of TB and patient socioeconomic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; HIV; Coinfection; Logistic regression.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200162

Clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV
Provedor de dados: 55
Autores: Eduardo Lorens,Braga; André Castro,Lyra; Fabrizio,Ney-Oliveira; Lourianne,Nascimento; Adriano,Silva; Carlos,Brites; Rosicreuza,Marbak; Luiz Guilherme Costa,Lyra; Manuel L.,Ribeiro Neto; Koonj Asvin,Shah.
Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A - 65 co-infected HCV/HIV patients, ii) group B - 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; HIV; Co-infection; Clinical course; HCV genotype.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100004

Clinical and laboratory characteristics of severe fever with thrombocytopenia syndrome in Chinese patients
Provedor de dados: 55
Autores: Weng,Yali; Chen,Nian; Han,Yaping; Xing,Yiping; Li,Jun.
Severe fever with thrombocytopenia syndrome (SFTS) associated with severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging infectious disease. 12 patients with severe fever with thrombocytopenia syndrome in our study were presented mainly with fever and severe malaise. The clinical manifestations typically became worse on the 6th or 7th day. The average fever time is 9.11 ± 1.54 days. Most of them had multiorgan dysfunction, and part of them had hemophagocytic lymphohistiocytosis histiocytosis (HLH). The characteristic laboratory findings in the early stage were the drop of white blood cells (WBC), platelets (PLT) and serum Ca++, while increase of aspartate amino transferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH)....
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Thrombocytopenia; Bunyaviridae infection; Clinical features; Laboratory characteristics.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100088

Clinical and laboratory profile of HIV-positive patients at the moment of diagnosis in Bahia, Brazil
Provedor de dados: 55
Autores: Sá,Márcia Sampaio; Sampaio,Julio; Haguihara,Thiago; Ventin,Fernando Oak; Brites,Carlos.
In Brazil, current trends of the AIDS epidemic include an increase in transmission through heterosexual contact, predominantly from men to women, with more cases of AIDS in women and more children contaminated by vertical transmission. There is also a high proportion of cases in poor people or people living in small towns. HIV-infected patients with high levels of immunodeficiency are frequently hospitalized after their first visit to the clinic due to opportunistic infections, characteristic of advanced disease. This study characterized the clinical and laboratory pattern of AIDS in a sample of patients attended for the first time in the AIDS clinic of the Federal University of Bahia Hospital (HUPES) in Salvador, Brazil. We revised medical charts of cases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV infection; Stage of disease; Brazil.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400004

Clinical and microbiological characteristics of bloodstream infections in a tertiary hospital in Maceió, Alagoas, Brazil
Provedor de dados: 55
Autores: Tenório,Maria Tereza Freitas; Porfírio,Zenaldo; Lopes,Antonio Carlos; Cendon,Sonia.
We observed the clinical and microbiological characteristics of several stages of bloodstream infections (BSI), as well as the mortality attributed to it in a tertiary hospital in the northeast of Brazil (in the city of Maceió, Alagoas). A prospective cohort of 143 patients who had at least one positive blood culture was enrolled in the study. Their clinical evolution was followed up for 30 days from October 2005 to December 2006. The relation among the qualitative variables was verified through Chi-square test. The significance level was 5%. The statistical package adopted was SPSS 15.0 for Windows. Up to the thirtieth day, 30.1% of the patients presented bacteremia and 69.9% developed sepsis.Among these, 20.3% developed severe sepsis and 10.5% septic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bloodstream infections; Blood cultures; Bacteremia; Spesis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200011

Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017
Provedor de dados: 55
Autores: Fang,Lan-fang; Zhang,Piao-piao; Wang,Jie; Yang,Qing; Qu,Ting-ting.
ABSTRACT  Background: This study aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis from 2013 to 2017 in a major teaching hospital in China.  Methods: Trends in antifungal drug susceptibility of 217 consecutive non-repetitive cryptococcal isolates collected from patients of an university hospital in China were analyzed between 2013 and 2017. Of those, 98 isolates were conserved for identification by internal transcribed spacer (ITS) sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) system. Multilocus sequence typing (MLST) was used to designate molecular types. Clinical characteristics of the 98 patients with cryptococcosis during the period of 2013-2017...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcosis; Cryptococcus neoformans; Multilocus sequence typing (MLST); Antifungal susceptibility; Human immunodeficiency virus (HIV).
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100007

Clinical and microbiological characteristics of OXA-23- and OXA-143-producing Acinetobacter baumannii in ICU patients at a teaching hospital, Brazil
Provedor de dados: 55
Autores: Neves,Francelli Cordeiro; Clemente,Wanessa T.; Lincopan,Nilton; Paião,Isabela D.; Neves,Patrícia R.; Romanelli,Roberta M.; Lima,Stella S.S.; Paiva,Luciene F.; Mourão,Paulo Henrique O.; Nobre-Junior,Vandack A.
ABSTRACT  Background: Carbapenem-resistant Acinetobacter baumannii (CRAb) is an important cause of nosocomial infections especially in intensive care units. This study aimed to assess clinical aspects and the genetic background of CRAb among ICU patients at a Brazilian teaching hospital.  Methods: 56 critically ill patients colonized or infected by CRAb, during ICU stay, were prospectively assessed. Based on imipenem MIC ≥ 4 µg/mL, 28 CRAB strains were screened for the presence of genes encoding metallo-β-lactamases and OXA-type β-lactamases. The blaOXA-type genes were characterized by PCR using primers targeting ISAba-1 or -3. Genetic diversity of blaOXA-positive strains was determined by ERIC-PCR analysis.  Results: Patient's mean age (±SD) was 61...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Carbapenem resistance; BlaOXA-23; BlaOXA-143.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600556

Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
Provedor de dados: 55
Autores: Beirão,Elisa Maria; Furtado,Juvencio Jose Duailibe; Girardello,Raquel; Ferreira Filho,Heli; Gales,Ana Cristina.
In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Klebsiella pneumonia; KPC; Hospital infection; Carbapenemase.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013

Clinical and microbiological characterization of pneumonia in mechanically ventilated patients
Provedor de dados: 55
Autores: Medell,Manuel; Hart,Marcia; Marrero,Odalys; Espinosa,Fidel; Oca,Zurelys Montes de; Valdés,Rodolfo.
OBJECTIVE: To characterize mechanical ventilation-associated pneumonia (MVAP). METHOD: This is an observational descriptive study to characterize MVAP in 61 ventilated patients admitted in the intensive care units of the Hermanos Ameijeiras hospital during 2011. This study also aimed to isolate the bacteria causing MVAP and characterize their resistance to antibiotics. RESULTS: 51 (83.60%) patients presented pulmonary infiltrates and 35 (50.81%) presented a clinical score &gt; 6 according to the Clinical Pulmonary Infection Score. Acinetobacter baumannii and Pseudomonas aeruginosa were the most frequently isolated microorganisms from patients with MVAP. Both microorganisms showed a high resistance to antibiotics. Carbapenems were the most frequent used...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial agents; Pneumonia; Respiratory care units.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500007

Clinical and microbiological implications of invasive pneumococcal disease in hospitalized patients (1998–2013)
Provedor de dados: 55
Autores: Medeiros,Marta Inês Cazentini; Negrini,Bento Vidal de Moura; Silva,Jorgete Maria e; Almeida,Samanta Cristine Grassi; Guerra,Maria Luiza Leopoldo Silva; Andrade,Denise de.
Abstract  Introduction Infections caused by Streptococcus pneumoniae (pneumococcus) still represent a challenge for health systems around the world.  Objective The objective of this study was to assess microbiological and clinical aspects in hospitalized patients with invasive pneumococcus disease between 1998 and 2013.  Materials and methods This was a retrospective study that analyzed the results of pneumococcus identification, serotyping, and susceptibility testing found in the Adolfo Lutz Institute databank. Personal variables, medical history and clinical outcome of patients admitted with invasive pneumococcal disease were analyzed. These were obtained from records of a public teaching hospital – Hospital das Clínicas Faculdade de Medicina Ribeirão...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Serotypes; Death; Comorbidity.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300004

Clinical and microbiological observational study on AmpC β-lactamase-producing Enterobacteriaceae in a hospital of Nepal
Provedor de dados: 55
Autores: Baral,Pankaj; Neupanea,Sanjiv; Shresthac,Basudha; Ghimirea,Kashi Ram; Marasinia,Bishnu Prasad; Lekhaka,Binod.
Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates, 64 (27.8%) were found to produce ABL in our study. Escherichia coli (83.9%) was a predominant pathogen, followed by Citrobacter freundii (5.2%). A significant proportion of ABL-producing isolates (81.3%) were found to be multidrug resistant against commonly used antibiotics. Univariate analysis showed that prior history of taking antibiotics (odds ratio [OR], 5.278; confidence interval [CI], 2.838-9.817; p &lt;...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: AmpC β-lactamase; Enterobacteriaceae; Antibiotic resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200022

Clinical and nutritional profile of individuals with chagas disease
Provedor de dados: 55
Autores: Geraix,Juliana; Ardisson,Lidiane Paula; Marcondes-Machado,Jussara; Pereira,Paulo Câmara Marques.
Chagas disease (CD), caused by the protozoan Trypanossoma cruzi, affects approximately 18 million individuals in the Americas, 5 million of which live in Brazil. Most chronic sufferers have either the indeterminate form of the disease, without organic compromise, or the cardiac or digestive forms. Despite the importance of this disease, there is no information on the effect of nutrition on CD evolution. We evaluated the clinical-nutritional profile of individuals with CD treated at the Tropical Diseases Nutrition Out-Patient Clinic of the Botucatu School of Medicine, UNESP. A retrospective cohort study was performed between 2002 and 2006, on 66 patients with serum and parasitological diagnosis of CD. Epidemiological, clinical, nutritional, and biochemical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chagas disease; Nutrition; Dyslipidemia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400008

Clinical and radiological analysis of children and adolescents with tuberculosis in Bahia, Brazil
Provedor de dados: 55
Autores: Franco,Rosana; Santana,Maria Angélica; Matos,Eliana; Sousa,Virgínia; Lemos,Antônio Carlos M.
We reviewed the clinical and radiological characteristics of tuberculosis (TB) in children and adolescents at the Hospital Especializado Octávio Mangabeira, (HEOM) in Salvador, Bahia. This study included 275 TB patients aged 1 to 15 years seen between January 1990 and November 2001. Standardized forms were filled out on the basis of a review of patient records and x-rays. Through a retrospective and descriptive analysis, it was found that 51.6% were male, 35.3% were aged 1 to 5 years, 28% were aged 6 to 10 and 36.7% were aged 11 to 15. Among all patients, 79.6% lived in the city of Salvador. A history of contact with TB was found in 63.9%, most frequently among children under 5 years old; 77.2% were vaccinated with Bacillus Calmette-Guerin (BCG). The most...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Children; Radiology; Chest x-ray.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100009

Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon
Provedor de dados: 55
Autores: Ramos Júnior,Wilson M; Sardinha,José FJ; Costa,Mônica RF; Santana,Marli S; Alecrim,Maria GC; Lacerda,Marcus VG.
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Malaria; Plasmodium vivax; Treatment; Primaquine; Hemolysis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400017

Clinical aspects of influenza A (H1N1) in HIV-infected individuals in São Paulo during the pandemic of 2009
Provedor de dados: 55
Autores: Bianco,Rosana Del; Santos,Maria Silvia Biagioni; Ribeiro,Maria Clara Gianna Garcia; Viso,Ana Teresa Rodriguez; Carvalho,Valquíria.
OBJECTIVE: To describe the clinical aspects of H1N1 among HIV coinfected patients seen at a reference center for AIDS treatment in São Paulo, Brazil. Design: Observational and prospective cohort study. METHODS: Descriptive study of clinical and laboratory investigation of HIV-infected patients with confirmed diagnosis of influenza A (H1N1) in 2009. We analyzed patients monitored in CRT/DST/AIDS, a specialized service for people living with HIV, located in São Paulo, Brazil. RESULTS: 108 individuals presented with symptoms of H1N1 infection at the CRT DST/AIDS in 2009. Eighteen patients (16.7%) had confirmation of the diagnosis of influenza A. Among the confirmed cases, ten (55.6%) were hospitalized and eight (44.4%) were outpatients. Dyspnea was present in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza A virus; H1N1 subtype HIV acquired immunodeficiency syndrome.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200015

Clinical aspects of pediatric AIDS cases notified in the state of Amazonas, 1991-2009
Provedor de dados: 55
Autores: Soeiro,Claudia Marques de Oliveira; Miranda,Angelica Espinosa; Saraceni,Valeria; Talhari,Sinesio; Ferreira,Luiz Carlos de Lima.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400025

Clinical correlates of pp65 antigenemia monitoring in the first months of post kidney transplant in patients undergoing universal prophylaxis or preemptive therapy
Provedor de dados: 55
Autores: Carvalho,Fabiana Rabe; Cosendey,Rachel Ingrid Juliboni; Souza,Cintia Fernandes; Medeiros,Thalia; Menezes,Paulo Alexandre; Silva,Andrea Alice; Almeida,Jorge Reis; Lugon,Jocemir Ronaldo.
Abstract  Introduction: Human cytomegalovirus is a major cause of morbidity in kidney transplant patients.  Objectives: We aimed to study viral replication and serological response in the first months post kidney transplant in patients undergoing universal prophylaxis or preemptive therapy and correlate the findings with the clinical course of Human cytomegalovirus infection.  Patients and methods: Independent from the clinical strategy adopted for managing Human cytomegalovirus infection, prophylaxis versus preemptive therapy, the pp65 antigenemia assay and serological response were assessed on the day of transplantation, and then weekly during the first three months of post-transplant.  Results: From the 32 transplant recipients, 16 were positive for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Pp65 antigenemia; Kidney transplant; Universal prophylaxis; Preemptive therapy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100051

Clinical correlation between Treponema pallidum infection and agenesis of the gallbladder
Provedor de dados: 55
Autores: Stanzani,Gianluca; Virgilio,Edoardo; Badiali,Marco.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500023

Clinical, endoscopic and prognostic aspects of primary gastric non-hodgkin's lymphoma associated with acquired immunodeficiency syndrome
Provedor de dados: 55
Autores: Rezende,Rosamar Eulira Fontes; Mantelmacher,Marcos; Ferreira,Sandro da Costa; Hyppólito,Elodie Bomfim; Machado,Alcyone Artioli; Ardengh,José Celso; Módena,José Luiz Pimenta.
Primary gastric non-Hodgkin's lymphoma (NHL) is a co-morbidity that can be observed during the clinical course of acquired immunodeficiency syndrome (AIDS). We evaluated the prevalence, clinical-evolutive aspects and form of endoscopic presentation of primary gastric NHL associated with AIDS. Two hundred and forty-three HIV patients were submitted to upper digestive endoscopy, with evaluation of clinical, endoscopic and histological data. A CD4 count was made by flow cytometry and viral load was determined in a branched-DNA assay. Six cases (five men; mean age: 37 years; range: 29-46 years) of primary gastric NHL were detected. The median CD4 count was 140 cells/mm³ and the median viral load was 40,313 copies/mL. Upper digestive endoscopy revealed polypoid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Non-Hodgkin lymphoma; AIDS; Stomach; Upper digestive endoscopy.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100002

Clinical failure of vancomycin treatment of Staphylococcus aureus infection in a tertiary care hospital in southern Brazil
Provedor de dados: 55
Autores: Lutz,Larissa; Machado,Adão; Kuplich,Nadia; Barth,Afonso Luís.
We describe a case of clinical failure of vancomycin treatment of Staphylococcus aureus infection and the laboratory characteristics of the organism in a tertiary referral university hospital in southern Brazil. An 11-month-old male patient presented with pneumonia and S. aureus was isolated from his respiratory tract. Initial treatment with oxacillin and gentamicin was ineffective. Vancomycin was added to the regimen as the patient worsened, but after the 30th day of vancomycin treatment S. aureus was isolated from the blood. This isolate had a minimum inhibitory concentration (MIC) for vancomycin of 4 µg/mL. After pre-incubation with vancomycin the isolate displayed an increase in the expression of vancomycin resistance and colonies grew in the presence...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: S. aureus; Resistance; Vancomycin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300008

Clinical forms and outcome of tuberculosis in HIV-infected patients in a tertiary hospital in São Paulo - Brazil
Provedor de dados: 55
Autores: Klautau,Giselle Burlamaqui; Kuschnaroff,Tuba M.
Tuberculosis (TB)/HIV co-infection significantly changes the natural history of both diseases. Proper comprehension and clinical management of co-infected TB/HIV patients is still a challenge, particularly in places like Brazil, where both types of infection are prevalent. OBJECTIVES: Evaluate the frequency of the clinical forms of TB in HIV-infected patients; correlate the clinical forms of TB with the level of immunodeficiency; evaluate the response to therapy with different regimens for the treatment of TB; identify potential prognostic factors in TB/HIV patients. MATERIAL AND METHODS: The following data were collected at the beginning of the study: medical history, epidemiological background, physical examination, and laboratory evaluation (complete...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis (TB); Prognostic factors; Co-infection TB/HIV; HAART.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600004

Clinical implications of vancomycin susceptibility testing in Staphylococcus aureus
Provedor de dados: 55
Autores: Mimica,Marcelo J.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200028

Clinical investigation for infections caused by Enterobacteriaceae in intensive care unit of Anhui, China
Provedor de dados: 55
Autores: Sun,Jing; Hu,Li-Fen; Wang,Min; Shi,Wei; Xu,Xi-Hai; Cheng,Jun; Ma,Tai; Luo,Xiao-Ming; Wang,Zhong-Xin; Ye,Ying; Li,Jia-Bin.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100023

Clinical management of a patient with drug dependence who attempted suicide while receiving peginterferon therapy for chronic hepatitis C
Provedor de dados: 55
Autores: Fábregas,Bruno Cópio; Moura,Alexandre Sampaio; Marciano,Renata Cristiane; Carmo,Ricardo Andrade; Teixeira,Antônio Lúcio.
Pegylated interferon-alpha combined with ribavirin is the current gold standard treatment for chronic hepatitis C. Illicit drug dependence is not a rare co-morbidity among chronic hepatitis C population, what can make antiviral treatment an outmost challenge. Despite high sustained virological response rate following antiviral treatment, serious psychiatric adverse reactions may occur, like depression and suicide attempt. We report a patient with recurrent depressive disorder, previous history of suicide attempt and illicit drug dependence. We discuss the singularities and challenges of managing this patient in order to complete the antiviral treatment.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Interferon-alpha; Chronic hepatitis C; Depression; Suicide attempt; Drug addiction.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500015

Clinical management of leprosy patients during the yellow fever outbreak in Brazil
Provedor de dados: 55
Autores: Albuquerque,Rachel Gimenes; Tomimori,Jane; Floeter-Winter,Lucile Maria; Tufik,Sergio; Andersen,Monica Levy.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600503

Clinical manifestations of primary syphilis in homosexual men
Provedor de dados: 55
Autores: Bjekić,Milan; Marković,Milica; Šipetić,Sandra.
At the beginning of a new millennium, syphilis incidence has been increasing worldwide, occurring primarily among men who have sex with men (MSM). The clinical features of primary syphilis among MSM is described, a case-note review of the primary syphilis (PS) patients who attended the Institute of Skin and Venereal Diseases. The diagnosis was assessed based upon the clinical features and positive syphilis serology tests. Among 25 patients with early syphilis referred during 2010, PS was diagnosed in a total of 13 cases. In all patients, unprotected oral sex was the only possible route of transmission, and two out of 13 patients had HIV co-infection. Overall, 77% of men presented with atypical penile manifestation. The VDRL test was positive with low...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Primary syphilis; Men who have sex with men.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400014

Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil
Provedor de dados: 55
Autores: Sáfadi,Marco A. P.; Berezin,Eitan N.; Farhat,Calil K.; Carvalho,Eduardo S.
We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease. Follow-up evaluations were made of 43 children with congenital toxoplasmosis referred to Santa Casa de São Paulo, during a period of at least five years. Selection of the cases was based in clinical and laboratory criteria. A clear predominance of children with subclinical presentation of the disease at birth (88%) was found. Of the 43 children, 22 (51%) developed neurological manifestations. Using skull radiography, we detected neuroradiologic alterations in seven children (16%) and with tomography in 33 children (77%). Neurological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital toxoplasmosis; Chorioretinitis; Neurologic manifestation.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500007

Clinical presentation and renal evaluation of human visceral leishmaniasis (kala-azar): a retrospective study of 57 patients in Brazil
Provedor de dados: 55
Autores: Daher,Elizabeth F.; Evangelista,Leandro F.; Silva Júnior,Geraldo B.; Lima,Rafael S.A.; Aragão,Eveline B.; Arruda,Germana A.J.C.; Galeano,Noemi M.F.; Mota,Rosa M.S.; Oliveira,Rodrigo A.; Silva,Sônia L.
Visceral leishmaniasis is an endemic disease caused by various species of Leishmania. We made a retrospective study of 57 consecutive patients with visceral leishmaniasis in Brazil. Patients with visceral leishmaniasis were identified using the registries of the São José Infectious Diseases Hospital. The sample was divided into two groups: patients with serum creatinine (Scr) &lt;1.3mg/dL and Scr &gt; 1.3mg/dL. We compared these two groups for differences in clinical manifestations and laboratory features. Patients' mean age was 28 ± 18 years old; 74% were male. The main clinical symptoms and signs presented in the initial evaluation were: fever (97%), splenomegaly (96.4%), weight loss (95.5%), pallor (93.6%), cough (89.7%), hepatomegaly (87.2%), asthenia...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; Kala-azar; Symptoms; Acute renal failure.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400015

Clinical presentation of leptospirosis: a retrospective study of 201 patients in a metropolitan city of Brazil
Provedor de dados: 55
Autores: Daher,Elizabeth F; Lima,Rafael SA; Silva Júnior,Geraldo B; Silva,Eveline C; Karbage,Nahme NN; Kataoka,Raquel S; Carvalho Júnior,Paulo C; Magalhães,Max M; Mota,Rosa MS; Libório,Alexandre B.
INTRODUCTION: leptospirosis is a zoonosis of worldwide importance. The disease is endemic in Brazil. This study was conducted to describe the clinical and laboratory presentation of leptospirosis in a metropolitan city of Brazil. METHODS: this is a retrospective study including 201 consecutive patients with leptospirosis admitted to tertiary hospitals in Fortaleza, Brazil, between 1985 and 2006. All patients had clinical and epidemiological data suggestive of leptospirosis, and positive laboratorial test for leptospirosis (microscopic agglutination test, MAT, higher than 1:800). RESULTS: a total of 201 patients were included, with mean age of 38.9 ± 15.7 years; 79.1% were male. The mean length from onset of symptoms to admission was 7 ± 3 days. The main...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Clinical manifestations; Laboratory findings; Mortality.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100002

Clinical relevance of rhinovirus infections among adult hospitalized patients
Provedor de dados: 55
Autores: Fica,Alberto; Dabanch,Jeannette; Andrade,Winston; Bustos,Patricia; Carvajal,Ita; Ceroni,Carolina; Triantaﬁlo,Vjera; Castro,Marcelo; Fasce,Rodrigo.
Human rhinovirus (HRV) is an emerging viral pathogen.  Aim: To characterize a group of patients admitted due to infection by this agent in a general hospital in Chile.  Methods:  Cases were identiﬁed by RT-PCR for 1 year through active surveillance of patients admitted with severe respiratory illness. Diagnosis was not available during hospitalization. Thirty-two cases were identiﬁed, 90% were ≥60 years old or had co-morbid conditions. Human rhinovirus-related admissions represented 23.7% of hospitalization due to severe acute respiratory infections among adults and ranked second to inﬂuenza (37.8%). Patients presented with pneumonia (68.8%), decompensated chronic lung conditions (21.9%), heart failure or inﬂuenza-like illness (6.3% each). Admission to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rhinovirus; Respiratory tract infections; Viral pneumonia; Reverse transcriptase polymerase chain reaction; AdultHospitalization.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200118

Clinical risk factors for Clostridium difficile-associated diseases
Provedor de dados: 55
Autores: Cho,Sung Min; Lee,Jae Joon; Yoon,Hee Jung.
Many factors appear to influence the chance of acquiring Clostridium difficile (C. difficile) infection, and an accurate identification of risk factors could be beneficial in many ways. Thus, in the present study, clinical risk factors for C. difficile-associated disease (CDAD) in Korea were identified. A total of 93 patients who met the inclusion criteria and 186 age/gender/ward/admission period-matched control patients were included in this study. Statistically significant associations were found with presence of chronic lung diseases (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.25-9.32; p = 0.017), presence of ileus (OR, 10.05; 95% CI, 2.42-41.80; p = 0.001), presence of intensive care unit (ICU) stay (OR, 9.79; 95% CI, 3.03-31.68; p &lt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risk factors; Clostridium difficile-associated; Diseases.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300007

Clinical significance of different bacterial load ofMycoplasma pneumoniae in patients with Mycoplasma pneumoniae pneumonia
Provedor de dados: 55
Autores: Jiang,Wujun; Yan,Yongdong; Ji,Wei; Wang,Yuqing; Chen,Zhengrong.
OBJECTIVE:This retrospective study was conducted to investigate the clinical significance of differentMycoplasma pneumoniae bacterial load in patients with M. pneumoniae pneumonia (MP) in children.METHODS:Patients with MP (n=511) were identified at the Children's Hospital Affiliated to Soochow University database during an outbreak of MP between January 2012 and February 2013.RESULTS:Comparing patients with high and low bacterial load those with higher loads were significantly older (p&lt;0.01) and had fever significantly more frequently (p=0.01). Presence of wheezing at presentation was associated with low bacterial load (p=0.03). Baseline positive IgM was present in 93 (56.4%) patients with high bacterial load compared to 46 (27.8%) patients with low...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycoplasma pneumoniae; Pneumonia; Polymerase chain reaction; Serology.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200124

Clinical signs, diagnosis, and case reports of Vaccinia virus infections
Provedor de dados: 55
Autores: Silva,Daniela Carla Medeiros; Moreira-Silva,Eduardo Augusto dos Santos; Gomes,Juliana de Assis Silva; Fonseca,Flávio Guimarães da; Correa-Oliveira,Rodrigo.
Vaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. Then, pustules and ulcerated lesions surrounded by edema and erythema follow, as well as local lymphadenopathy that can last for weeks. Cure and healing of the lesions occur over several weeks, leaving a typical scar in the skin of people and animals affected. The infection definitive diagnosis is made through morphological characterization of the virus by use of electron microscopy, followed by PCR for specific viral genes. Since 1963, circulating orthopoxviruses in infectious outbreaks in several regions of Brazil have been...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Poxviridae infections; Virology; Outbreaks; Zoonoses; Vaccinia virus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200003

Clinical tomographic correlations of 220 patients with neurocisticercosis, Bahia, Brazil
Provedor de dados: 55
Autores: Andrade-Filho,Antônio de Souza; Figuerôa,Luiz Frederico da Silva; Andrade-Souza,Victor Mascarenhas.
Neurocysticercosis (NCC) is a common parasitic disease in our region, presenting diversity of neurological symptoms and signs. The present study has as primary objective an evaluation of the NCC's clinical and epidemiological profile within Bahia State, by means of a prospective study of 220 patients diagnosed from March 1988 to March 1999, with a follow-up of six months. Exams, such as Computed Cranial Tomography Scan (CT), Cerebral Spine Fluid (CSF) and Electroencephalogram (EEG), were accomplished in three distinct moments of these patients' evolution: at starting or diagnostic point (zero time), at after-intervention period (one month after treatment), and at control period (six months after treatment).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neurocysticercosis; Computadorized tomography; Epidemiology; Clinical.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100025

Clinical-epidemiological evaluation of respiratory syncytial virus infection in children attended in a public hospital in midwestern Brazil
Provedor de dados: 55
Autores: Calegari,Tatiany; Queiroz,Divina A.O.; Yokosawa,Jonny; Silveira,Hélio L.; Costa,Lourenço F.; Oliveira,Thelma F.M.; Luiz,Lysa N.; Oliveira,Renata C.; Diniz,Francisco C.; Rossi,Lívia M.G.; Carvalho,Cláudio J; Lima,Ana Cláudia; Mantese,Orlando C.
Respiratory syncytial virus (RSV) is responsible for annual respiratory infection outbreaks in infants and young children worldwide, frequently causing bronchiolitis and pneumonia. We evaluated clinical and epidemiological features of acute respiratory infections (ARIs) caused by respiratory syncytial virus (RSV) in children less than five years old. Nasopharyngeal aspirate samples from children with ARI symptoms, attended at the 'Hospital das Clínicas' - Federal University of Uberlândia, MG, Brazil, were collected and tested for RSV by the immunofluorescence assay (IFA). Patients' clinical and epidemiological data were also obtained. From April 2000 to June 2003, 317 nasopharyngeal samples were collected from children less than 54 months old. Seventy-six...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Respiratory syncytial virus; Respiratory infection; Children.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200006

Clonal dissemination of vancomycin-resistant Enterococcus faecium ST412 in a Brazilian region
Provedor de dados: 55
Autores: Alves,Geraldo da Silva; Pereira,Monalessa Fábia; Bride,Lais de Lima; Nunes,Ana Paula Ferreira; Schuenck,Ricardo Pinto.
ABSTRACT Vancomycin-resistant Enterococcus faecium (VREfm) has emerged as an important global nosocomial pathogen, and this trend is associated with the spread of high-risk clones. Here, we determined the genetic and phenotypic features of 93 VREfm isolates that were obtained from patients in 13 hospitals in Vitória, Espírito Santo, Brazil, during 2012-2013. All the isolates were vancomycin-resistant and harbored the vanA gene. Only 6 (6.5%) of the VREfm isolates showed the ability to form biofilm. The 93 isolates analyzed belong to a single pulsed-field gel electrophoresis lineage and presented six subtypes. MLST genotyping showed that all VREfm belonged to ST412 (the high-risk clone, hospital-adapted). The present study describes the dissemination of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Enterococcus faecium; VRE; ST412; Biofilm.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600656

Clostridium difficile contamination in retail meat products in Brazil
Provedor de dados: 55
Autores: Pires,Renata N.; Caurio,Cassia F.B.; Saldanha,Gabriele Z.; Martins,Andreza F.; Pasqualotto,Alessandro C.
ABSTRACT  Introduction Clostridium difficile is an important cause of diarrhoea, particularly in patients receiving antibiotic therapy. Recent studies have shown that a substantial proportion of C. difficile infections are acquired in the community, as a zoonotic disease. Brazil is a large exporter of meat and so far no study has evaluated meat contamination with C. difficile spores.  Methods Here we analysed 80 retail meat products purchased from local supermarkets in a Brazilian metropolis (Porto Alegre, Southern Brazil). Samples from these products were grown in anaerobic conditions, and tested with a real time polymerase chain reaction test.  Results Contamination with C. difficile spores was not found in the study. Bacteria isolated from meat included...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Clostridium difficile; Retail meat; Community-acquired infection; Beef; Food contamination.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400345

Clostridium difficile outbreak caused by NAP1/BI/027 strain and non-027 strains in a Mexican hospital
Provedor de dados: 55
Autores: Morfin-Otero,Rayo; Garza-Gonzalez,Elvira; Aguirre-Diaz,Sara A.; Escobedo-Sanchez,Rodrigo; Esparza-Ahumada,Sergio; Perez-Gomez,Hector R.; Petersen-Morfin,Santiago; Gonzalez-Diaz,Esteban; Martinez-Melendez,Adrian; Rodriguez-Noriega,Eduardo.
Abstract  Background Clostridium difficile infections caused by the NAP1/B1/027 strain are more severe, difficult to treat, and frequently associated with relapses.  Methods A case–control study was designed to examine a C. difficileinfection (CDI) outbreak over a 12-month period in a Mexican hospital. The diagnosis of toxigenic CDI was confirmed by real-time polymerase chain reaction, PCR (Cepheid Xpert C. difficile/Epi).  Results During the study period, 288 adult patients were evaluated and 79 (27.4%) patients had confirmed CDI (PCR positive). C. difficilestrain NAP1/B1/027 was identified in 31 (39%) of the patients with confirmed CDI (240 controls were included). Significant risk factors for CDI included any underlying disease (p &lt; 0.001), prior...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difficile; Outbreak; 027 strain; Mexico.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100008

Cluster of Candida parapsilosis primary bloodstream infection in a neonatal intensive care unit
Provedor de dados: 55
Autores: Silva,Carmem Lúcia P. da; Santos,Rosana M. R. dos; Colombo,Arnaldo Lopes.
Candida parapsilosis is an increasingly important bloodstream pathogen in neonatal intensive care units (NICU). We investigated a cluster of bloodstream infections in a NICU to determine whether nosocomial transmission occurred. During a 3-day period, 3 premature infants hospitalized in the same unit presented with sepsis caused by C. parapsilosis. Electrophoretic karyotype of the organisms was performed by using pulsed field gel electrophoresis in a countour-clamped homogeneous electric field system. The isolate from 1 newborn could not be typed, and the isolates from the remaining 2 infants had identical patterns. All 3 cases are described. We conclude that nosocomial transmission of C. parapsilosis occurred and that neonates under intensive care may...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidemia; Nosocomial infections; Neonate.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100005

Clustering of Enterococcus faecalis infections in a cardiology hospital neonatal intensive care unit
Provedor de dados: 55
Autores: Strabelli,Tânia Mara Varejão; Cais,Daiane P.; Zeigler,Rogério; Siciliano,Rinaldo; Rodrigues,Cristhieni; Carrara,Dirceu; Neres,Suzi; Lessa,Sarita; Uip,David Everson.
Early identification of an outbreak is one of the main advantages of routine epidemiological surveillance. Enterococcus spp. used to be regarded as microorganisms of low pathogenicity, because they are part of the normal microbial flora of the gastrointestinal and genitourinary tract. Recently, they have emerged as important pathogenic agents, sometimes causing infections with high mortality rates. We studied a clustering of primary bloodstream infections caused by Enterococcus faecalis in a cardiology hospital neonatal intensive care unit (NICU). Four cases of primary bloodstream infection by E. faecalis were detected from April 15 to May 13, 2004, during active infection surveillance. The isolates were sensitive to glycopeptides. Some aspects of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococcus faecalis; Clustering; Neonatal intensive care unit; Bloodstream; Infection.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200008

Coexistence of low levels of HBsAg and high levels of anti-HBs may increase risk of hepatocellular carcinoma in chronic hepatitis B patients with high HBV load
Provedor de dados: 55
Autores: Jin,Zi-zheng; Jin,Fang-fang; Liu,Xin; Liu,Ning; Wen,Feng; Lou,Jin-li.
ABSTRACT  Objective: The clinical significance of coexistence of HBsAg/anti-HBs in chronic hepatitis B (CHB) patients remains controversial. This study was aimed to assess the association of this serological pattern with hepatocellular carcinoma (HCC) in patients with CHB.  Methods: In this cross-section study, 206 CHB patients with coexistence of HBsAg/anti-HBs and 206 CHB patients with HBsAg alone were included to evaluate the risk of HCC development by logistic regression analysis. In addition, a retrospective cohort of 260 patients with CHB was recruited to estimate the cumulative incidence of HCC by Kaplan-Meier analysis.  Results: The serological pattern of coexistence of HBsAg/anti-HBs, with high levels of ("High") HBsAg/low levels of ("Low")...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; HBsAg; Hepatocellular carcinoma.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500343

Coffee has hepatoprotective benefits in Brazilian patients with chronic hepatitis C even in lower daily consumption than in American and European populations
Provedor de dados: 55
Autores: Machado,Silmara Rodrigues; Parise,Edison Roberto; Carvalho,Luciana de.
The potential role of coffee as a hepatoprotective substance for chronic liver diseases has been widely discussed. Our main aim was to evaluate the effect of coffee intake regarding clinical, biochemical tests and liver biopsy data in treatment naïve patients with chronic hepatitis C. One hundred and thirty-six patients with chronic hepatitis C, diagnosed through liver biopsy, or by means of clinical, ultrasound or endoscopic signs of cirrhosis, were assessed by determination of biochemical tests, metabolic and morphological alterations. Food frequency was scrutinized by using a structured questionnaire. Coffee intake represented more than 90% of the total daily caffeine, and the 75th percentile was 4-Brazilian coffee-cup/day (&gt;255mL/day or &gt;123mg...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coffee; Caffeine; Hepatitis C; Fibrosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200170

Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis and delay in starting antiretroviral therapy for AIDS patients
Provedor de dados: 55
Autores: Brites,C; Goyanna,F; França,LG; Pedroso,C; Netto,EM; Adriano,S; Sampaio,J; Harrington Jr,W.
OBJECTIVE: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. METHODS: Retrospective, comparative study. RESULTS: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (23.1%) had detectable antibodies against HTLV-I/II. The major risk factor associated with coinfection by HTLV was intravenous drug use (57.7% of coinfected patient versus 9.2% of HTLV seronegative patients, p &lt; 0.0001). Coinfected patients had higher absolute lymphocyte counts (1,921 + 762 versus 1,587 + 951, p = 0.03). Both groups of patients had similar means of CD4+ and CD8+ cell counts. However, among patients with AIDS CD4+ cell counts were significantly higher among those coinfected with HTLV-I/II...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HTLV-I/II; Coinfection Strongyloidiasis; CD4/CD8.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100002

Co-infection cases of human common respiratory viruses in Beijing, 2010-2012
Provedor de dados: 55
Autores: Cui,Shu-Juan; Shi,Wei-Xian; Huang,Fang; Pang,Xing-Huo; Deng,Ying.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200032

Co-infection with hepatitis B virus and hepatitis C virus
Provedor de dados: 55
Autores: Mitre,Heloísa Pedrosa; Mendonça,João Silva de.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700011

Co-infection with hepatitis C virus and human T lymphocyte virus
Provedor de dados: 55
Autores: Alves,Carlos Brites.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700012

Colistin resistance in non-fermenting Gram-negative bacilli in a university hospital
Provedor de dados: 55
Autores: Santos,Silvana Oliveira dos; Rocca,Sthefanine Martins La; Hörner,Rosmari.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600649

Colonization by Pneumocystis jirovecii in patients with chronic obstructive pulmonary disease: association with exacerbations and lung function status
Provedor de dados: 55
Autores: Cañas-Arboleda,Alejandra; Hernández-Flórez,Catalina; Garzón,Javier; Parra-Giraldo,Claudia Marcela; Burbano,Juan Felipe; Cita-Pardo,José Enrique.
ABSTRACT Exposure to Pneumocystis jirovecii (P. jirovecii) can lead to a wide variety of presenting features ranging from colonization in immunocompetent patients with lung disease, to invasive infections in immunocompromised hosts. Colonization by this fungus in patients with chronic obstructive pulmonary disease (COPD) could be associated with higher rates of exacerbations and impaired lung function in these patients.Our objective was to determine whether colonization by P. jirovecii in patients with COPD is associated with increased exacerbations and deterioration of lung function.This was a prospective cohort study on patients with COPD. All participants meeting selection criteria underwent clinical and microbiological assessments and were then...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumocystis spp.; Pneumocystis jirovecii; Chronic obstructive pulmonary disease; Colombia.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500352

Colonization by Streptococcus agalactiae during pregnancy: maternal and perinatal prognosis
Provedor de dados: 55
Autores: El Beitune,Patrícia; Duarte,Geraldo; Maffei,Cláudia Maria Leite.
We reviewed colonization by group B Streptococcus beta-haemolyticus of Lancefield (SGB), or Streptococcus agalactiae, in pregnant women, and the consequences of infection for the mother and newborn infant, including factors that influence the risk for anogenital colonization by SGB. We also examined the methods for diagnosis and prophylaxis of SGB to prevent early-onset invasive neonatal bacterial disease. At present, it is justifiable to adopt anal and vaginal SGB culture as part of differentiated obstetrical care in order to reduce early neonatal infection. The rates, risk factors of maternal and neonatal SGB colonization, as well as the incidence of neonatal disease, may vary in different communities and need to be thoroughly evaluated in each country...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnancy; Prognosis; Streptococcus agalactiae.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400002

Combined pegylated interferon and ribavirin for the management of chronic hepatitis C in a prison setting
Provedor de dados: 55
Autores: Sabbatani,Sergio; Giuliani,Ruggero; Manfredi,Roberto.
The elevated frequency of chronic hepatitis C virus (HCV) infection found among prison inmates, and the availability of improved pharmacological cure for this potentially life-threatening disorder, make investigations conducted in this somewhat neglected area very relevant, since only a few, open-label experiences have been reported till now. In the metropolitan prison of Bologna (Italy), HCV seroprevalence was found to be over 31% in 2003, so that a pilot feasibility study based on treatment with pegylated interferon plus ribavirin was initiated, after careful counseling carried out by a joint commission of health care personnel of the correctional facility and infectious diseases consultants. Thirty-nine patients were enrolled, and despite expected...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Pegylated interferon; Ribavirin; Management; Inmates; Prison.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400012

Combined use of Western blot/ELISA to improve the serological diagnosis of human tuberculosis
Provedor de dados: 55
Autores: Beck,S. T.; Leite,O. M.; Arruda,R. S.; Ferreira,A. W.
Two recombinant antigens and a crude bacterial antigen of a wild M. tuberculosis strain were used to detect specific IgG antibodies in sera from 52 patients with pulmonary tuberculosis, confirmed by an acid-fast smear and serum culture of these patients and that of 25 contacts. The patients were not infected with HIV. We evaluated the sensitivity and specificity of ELISA, based on the recombinant TbF6® and TbF6/DPEP antigen and a search for reactivity patterns in the Western blot technique, using whole mycobacterium antigen. Serum samples from 22 healthy individuals and from 30 patients with lung diseases other than tuberculosis were used as controls. The best ELISA results were obtained with the TbF6/DPEP antigen combination, which gave 85% sensitivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: M. tuberculosis; Recombinant antigens; Diagnosis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100007

Comment on: "Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis"
Provedor de dados: 55
Autores: Ji,Fanpu; Cai,Zhifang; Deng,Hong.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400024

Comment on "Viral acute gastroenteritis: clinical and epidemiological features of co-infected patients"
Provedor de dados: 55
Autores: Luchs,Adriana.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100022

Common infectious diseases and skin test anergy in children from an urban slum in Northeast Brazil
Provedor de dados: 55
Autores: Castro,Melânia X.; Soares,Alberto M.; Fonsêca,Walter; Rey,Luís C.; Guerrant,Richard L.; Lima,Aldo A. M.
BACKGROUND: Acute respiratory infection (ARI), diarrheal disease (DD) and infective dermatitis (ID) are important causes of morbidity in children under five, in Northeast Brazil. Objectives: (a) to evaluate the morbidity of ARI, DD and ID; and (b) to determine their association with cellular immunity in poor urban children from Fortaleza, Brazil. MATERIALS AND METHODS: A prospective cohort study. At enrollment, multipuncture skin-tests (Multitest CMI) were performed and interpreted according to standard procedures. Children were followed for infectious diseases by weekly home visits. RESULTS: Seventy-one children aged 6 to 21 months were recruited in an ongoing cohort of newborns. A mean of 39 (6 to 63) home visits per child were made, which detected 184.5...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Acute respiratory infection; Cellular immunity; Skin test; Child.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600006

Community acquired pneumonia among pediatric outpatients in Salvador, Northeast Brazil, with emphasis on the role of pneumococcus
Provedor de dados: 55
Autores: Nascimento-Carvalho,Cristiana M.C.; Lopes,Antônio A.; Gomes,Maria Daniela B.S.; Magalhães,Morgana P.; Oliveira,Juliana R.; Vilas-Boas,Ana Luisa; Ferracuti,Roberta; Brandileone,Maria Cristina C.; Guerra,Maria Luiza L.S.; Alves,Noraney N.; Athayde,Ledilce A.; Caldas,Renilza M.; Barberino,Maria Goreth M. A.; Duarte,Jussara; Brandão,Maria Angélica S.; Rocha,Heonir; Benguigui,Yehuda; Di Fabio,José Luis.
Pneumonia is one of the leading causes of hospitalization and death among children in developing countries, and mortality due to pneumonia has been associated with S. pneumoniae infection. This investigation was designed to describe the antimicrobial susceptibility and serotype patterns of pneumococcal strains recovered from the blood of children with community-acquired pneumonia (CAP) and to assess the clinical findings of pneumococcal bacteremic patients with pneumonia. In a 26 month prospective study, blood cultures were obtained as often as possible from children (&lt;16 years of age) diagnosed with CAP in two emergency rooms. Antimicrobial drug susceptibility tests and serotyping were performed when pneumococcus was identified. We studied 3,431 cases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Antimicrobial resistance; Serotypes; Blood culture; Community-acquired pneumonia; Children.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100003

Community-acquired methicillin-resistant Staphylococcus aureus carrying SCCmec type IV and V isolated from healthy children attending public daycares in northeastern Brazil
Provedor de dados: 55
Autores: Carvalho,Suzi P. de; Almeida,Jéssica B. de; Andrade,Yasmin M.F.S.; Silva,Lucas S.C. da; Oliveira,Arianne C. de; Nascimento,Flávia S.; Campos,Guilherme B.; Oliveira,Márcio V.; Timenetsky,Jorge; Marques,Lucas M.
Abstract Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) have increasingly been reported in healthy communities. This study aimed to assess the rate of S. aureus in general and MRSA in particular from nasal secretion of children in daycare centers in Vitória da Conquista, Brazil. The isolates were identified based on morphology, biochemical tests and by PCR. Detection of virulence genes, biofilm production, and susceptibility test by disk diffusion agar were performed. MRSA isolates were characterized by spa, SCCmec, and multilocus sequence typing (MLST). S. aureus were recovered from 70 (47.3%) of 148 children. Among the 11 MRSA strains (15.7%), two SCCmec types (IV and V) were detected. MLST identified four STs related to three...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: CA-MRSA; Antibiotic resistance; SCCmec; MLST.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400464

Community-acquired methicillin-resistant Staphylococcus aureus from skin and soft tissue infections (in a sample of Egyptian population): analysis of mec gene and staphylococcal cassette chromosome
Provedor de dados: 55
Autores: Sobhy,Nagat; Aly,Fatma; El Kader,Ola Abd; Ghazal,Abeer; Elbaradei,Amira.
BACKGROUND: Staphylococcus aureus has been recognized as an important pathogen associated with inpatients and community infections. Community-acquired methicillin-resistant S. aureus (CA-MRSA) infections commonly present as skin and soft-tissue infections (SSTIs). Treatment often includes incision and drainage with or without adjunctive antibiotics. OBJECTIVES: This study aimed to identify CA-MRSA infections both phenotypically and genotypically, to determine their spectrum of antibiotic resistance, and to establish the best scheme for molecular distinction between hospital-acquired MRSA (HA-MRSA) and CA-MRSA by staphylococcal cassette chromosome mec (SCCmec) typing and detection of Panton Valentine leukocidin (PVL). MATERIALS: 50 swabs, from skin and soft...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-acquired; Methicillin-resistant; Staphylococcus aureus.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500004

Community-acquired pneumonia at the Hospital de Clínicas de Porto Alegre: evaluation of a care protocol
Provedor de dados: 55
Autores: Mocelin,Clei Angelo; Santos,Rodrigo Pires dos.
To assess the adequacy of medical prescriptions for community-acquired pneumonia at the emergency department of the Hospital de Clínicas de Porto Alegre, we conducted a prospective cohort study, from January through April 2011. All patients with suspected pneumonia were selected from the first prescription of antimicrobials held in the emergency room. Patients with a description of pneumonia, community-acquired pneumonia, respiratory infection, or other issues related to community-acquired pneumonia were selected for review. Two-hundred and fifteen patients were studied. Adherence to the hospital care protocol was: 11.2% for the initial recommended tests (chest X-ray and collection of sputum sample), 34.4% for blood cultures, and 92.1% for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Community; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500001

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil
Provedor de dados: 55
Autores: Chedid,Maria Bernadete; Chedid,Márcio Fernandes; Ilha,Darcy Oliveira; Bozzetti,Mary Clarisse; Chaves,Letícia; Griza,Daniela; Dalcin,Paulo Roth.
As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CAP; Chlamydophila pneumoniae; Microimmunofluorescence; TWAR infections.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100018

Community-acquired pneumonia in the childhood: analysis of the diagnostic methods
Provedor de dados: 55
Autores: Requejo,Henry I. Z.
Immunological assays such as CIE, LA, and Dot-ELISA were compared in order to diagnose community-acquired pneumonia. Serum, pleural fluid and urine samples were comparatively employed for bacterial antigen detection. Dot-ELISA proved to be an original and practical alternative procedure for detecting bacterial polysaccharide antigens from pleural fluid and/or concentrated urine samples, providing a rapid diagnosis for pediatric patients with community-acquired pneumonia.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-acquired pneumonia; Streptococcus pneumoniae; Haemophilus influenzae; Bacterial pneumonia; Immunological methods.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200016

Comparative in vitro activities of seven new beta-lactams, alone and in combination with beta-lactamase inhibitors, against clinical isolates resistant to third generation cephalosporins
Provedor de dados: 55
Autores: Gupta,Varsha; Datta,Priya; Agnihotri,Nalini; Chander,Jagdish.
We examined the drug susceptibility pattern of Gram-negative bacilli to seven new beta-lactams. A total of 277 non-duplicate gramnegative bacilli strains belonging to the Enterobacteriaceae family, Pseudomonas and Acinetobacter species, isolated from various clinical samples were tested for susceptibility to imipenem, piperacillin/tazobactam, cefoperazone/sulbactam, ticarcillin/clavulanate, cefdinir, cefepime and cefpirome with the disk diffusion technique. The percentage resistance was low for imipenem (7.2%), piperacillin/tazobactam (2.8%), cefoperazone/sulbactam (5.4%). However, a high frequency of resistance was observed to ticarcillin/clavulanate (83.9%), cefdinir (70.6%), cefepime (45.5%) and cefpirome (84.4%). We conclude that imipenem,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beta-lactam; Beta-lactam/beta-lactamase inhibitor; Gram-negative bacilli.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100005

Comparative performances of serologic and molecular assays for detecting human T lymphotropic virus type 1 and type 2 (HTLV-1 and HTLV-2) in patients infected with human immunodeficiency virus type 1 (HIV-1)
Provedor de dados: 55
Autores: Campos,Karoline Rodrigues; Gonçalves,Maria Gisele; Costa,Nadia Aparecida; Caterino-de-Araujo,Adele.
ABSTRACT The present study evaluated several techniques currently available (commercial kits and in-house assays) for diagnosing human T lymphotropic viruses types 1 and 2 in two groups of patients enrolled at HIV/AIDS specialized care services in São Paulo: Group 1 (G1), n = 1608, 1237 male/371 female, median age 44.3 years old, majority using highly active antiretroviral therapy (HAART); G2, n = 1383, 930 male/453 female, median age of 35.6 years old, majority HAART naïve. Enzyme immunoassays [(EIA) Murex and Gold ELISA] were employed for human T lymphotropic viruses types 1 and 2 screening; Western blotting (WB), INNO-LIA (LIA), real-time PCR pol (qPCR), and nested-PCR-RFLP (tax) were used to confirm infection. Samples were considered human T...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1/2; HIV-1; Coinfection; Diagnosis; Immunoblotting; PCR; HAART.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300297

Comparative study of bacterial infection prevalence between cirrhotic patients with and without upper gastrointestinal bleeding
Provedor de dados: 55
Autores: Almeida,Delvone; Lopes,Antônio A; Santos-Jesus,Rogerio; Paes,Igelmar; Bittencourt,Helito; Paraná,Raymundo.
Bacterial infection is a frequent complication in patients with chronic liver disease, mainly during the advanced stages. There is evidence that the main factors that contribute to a predisposition to infection in cirrhotic patients are related to hepatic failure with consequent immunodeficiency. Invasive procedures (diagnostic or therapeutic) can predispose to bacterial infections, and upper gastrointestinal bleeding (UGB) is considered a potentially important risk factor. A group of cirrhotic patients (child B and C Pugh groups ) were evaluated retrospectively by chart reviews regarding the prevalence of bacterial infection during hospitalization to determine whether UGB was a risk factor. An infection was considered present if a specific organ system...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cirrhosis; Upper gastrointestinal bleeding; Bacterial infections; Spontaneous bacterial peritonitis.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300006

Comparative study of etiological diagnosis of nosocomial pneumonia
Provedor de dados: 55
Autores: Carvalho,Eliane Maria de; Massarollo,Paulo Celso Bosco; Levin,Anna S.; Isern,Maria Rita Montenegro; Pereira,Wilson Leite; Abdala,Edson; Rossi,Flavia; Mies,Sérgio.
Nosocomial pneumonia is a common complication in patients on mechanical ventilation and results in significant mortality. Diagnosis of pneumonia in patients who are intubated and under mechanical ventilation is difficult, even with the aid of clinical, laboratorial, and endoscopic tests. The objective of this study was to compare three methods of tracheal sputum collection in patients with a clinical and radiological diagnosis of pneumonia. Twenty-two patients with a clinical diagnosis of liver disease were enrolled, 18 years of age or older, 13 males and nine females, who had been mechanically ventilated over an intubation period of 5.86 ± 4.62 days. These patients were being treated in intensive care unit (ICU) of the Liver Transplantdepartment....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Microorganisms; Bronchoalveolar lavage; Tracheal aspiration; Closed aspiration system.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100015

Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia
Provedor de dados: 55
Autores: Codes,L.; Freitas,L.A.R. de; Santos- Jesus,R.; Vitvitski,L.; Silva,L.K.; Trepo,C.; Reis,M.G.; Paraná,R.
Hepatitis C virus displays a high degree of genetic mutation, with considerable heterogeneity, motivating clinical and biomolecular investigations. It is necessary to understand the effects of genotypes on the course of the disease, as well as their peculiarities at the regional level. OBJECTIVE: The study objective was to compare epidemiological, biochemical and histological aspects of hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. STUDY DESIGN: Data were collected retrospectively from outpatient medical records. MATERIALS AND METHODS: 127 patients with positive anti-HCV results were selected, based on detectable RNA-HCV (RT-PCR) of genotypes 1a, 1b and 3a. RESULTS: Thirty-nine (30.7%) individuals were infected by subtype 1a, 45 (35.4%) by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Genotype.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600009

Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major
Provedor de dados: 55
Autores: Brobey,Reynolds K. B.; Mei,Fang C.; Cheng,Xiaodong; Soong,Lynn.
The outcome of Leishmania infections is determined by both the parasite species and the host genetic makeup. While much has been learned regarding immune responses to this parasite, our knowledge on parasite-derived factors is limited. The recent completion of the L. major and L. infantum genome sequence projects and concurrent advancement in proteomics technology would greatly accelerate the search for novel Leishmania proteins. Using a proteomics-based approach to study species-specific Leishmania proteins, we developed high-resolution, broad pH (3-10) two-dimensional gel electrophoresis (2-DE) separations to determine protein-expression profiles between highly infectious forms of the parasitic species L. amazonensis (New World) and L. major (Old World)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania infections; Gel electrophoresis; Future studies.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100001

Comparative virulence of Scedosporium species in animal models
Provedor de dados: 55
Autores: Nweze,EI; Okafor,JI.
Scedosporium species are an emerging opportunist group of fungi that have been found to cause infections in both immunocompetent and non-immunocompetent individuals. The infections are not regularly distributed among different countries of the world either because of improper identification or other geographical reasons. Strange as it may, disseminated systemic infections have only been reported in some specific countries. We used a mouse model of disseminated infection to assess if strains from Nigeria were virulent and compared it to a few other strains from other countries. S. apiospermum isolated from Nigeria were clearly less virulent than those obtained elsewhere. This may be the reason why this group of fungi has not been associated with specific...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Scedosporium; Inocula; Virulence; Fungi.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300012

Comparing hospital infections in the elderly versus younger adults: an experience in a Brazilian University Hospital
Provedor de dados: 55
The elderly population will grow rapidly over the next 25 years, however there is little information about hospital infections in this group of patients in Brazil. We examined the prevalence of nosocomial and community infections in elderly (&gt;65 years) patients and their relationship with intrinsic and extrinsic risk factors in a Brazilian University Hospital. A total of 155 hospitalized elderly patients were evaluated, and clinical and demographic information about each patient was obtained from hospital records. The rates of nosocomial and community infections were 16.1% and 25.6%, respectively. When the elderly group with and without nosocomial infections was analyzed, practically all the risk factors considered (use of antibiotics, invasive devices,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Elderly; Nosocomial infections; Risk factors; Brazilian hospitals; Infection control.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300006

Comparison among the BED capture enzyme immunoassay test and AxSYM avidity index assay for determining recent HIV infection and incidence in two Voluntary Counselling and Testing Centres in Northeast Brazil
Provedor de dados: 55
Autores: Salustiano,Daniela Medeiros; Lima,Kledoaldo Oliveira de; Cavalcanti,Ana Maria Salustiano; Diaz,Ricardo Sobhie; Lacerda,Heloisa Ramos.
The aims of this study were to compare the automated AxSYM avidity assay index with the BED capture enzyme immunoassay test and to calculate the HIV-1 incidence using the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms within a population seeking the Voluntary Counselling and Testing Centres in two municipalities in the Metropolitan Region of Recife, Northeast of Brazil. An analysis was conducted in 365 samples that tested positive for HIV infection from frozen serum collected during the period 2006-2009. There was a similar proportion of males and females; most patients were heterosexual (86%) with a median age of 29 years. Of the 365 samples, 102 (28%) and 66 (18.1%) were identified as recent infections by BED capture enzyme...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Recent infection; Avidity index assay; BED-CEIA.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400449

Comparison between the gold standard DXA with calcaneal quantitative ultrasound based-strategy (QUS) to detect osteoporosis in an HIV infected cohort
Provedor de dados: 55
Autores: Roldan,Eugenia Quiros; Brianese,Nigritella; Raffetti,Elena; Focà,Emanuele; Pezzoli,Maria Chiara; Bonito,Andrea; Ferraresi,Alice; Lanza,Paola; Porcelli,Teresa; Castelli,Francesco.
ABSTRACT  Introduction: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture.  Methods: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound. The assessment of osteoporosis diagnostic accuracy was performed for calcaneal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteoporosis; HIV; Calcaneal ultrasound.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600581

Comparison between the jugular and subclavian vein as insertion site for central venous catheters: microbiological aspects and risk factors for colonization and infection
Provedor de dados: 55
Autores: Sadoyama,Geraldo; Gontijo Filho,Paulo Pinto.
Bacterial counts were made of catheter insertion site and of catheter tips to help determine risk factors associated with catheterization of the jugular and subclavian veins. Among the 116 patients included in this study, 69% had central venous catheters (CVC) in the subclavian vein. Seven or more days catheterization (p=0.001) and &gt;3 invasive devices (p=0.01) were infection risk factors associated with catheterization of the jugular vein. More than half of the patients presented high colony counts at the insertion site (&gt;200 CFU/20 cm²) and 27% of the catheter tips were contaminated. The risk factors associated with contaminated catheter tips were &gt;14 days hospital stay (p=0.02), &gt;7 days catheterization (p=0.01) and antibiotic therapy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CVC; Risk factor; CR-BSI; ORSA; ORCoNS.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200008

Comparison of a rapid cytomegalovirus pp65 antigenemia assay revealed by immunofluorescence to an in-house assay revealed by immunoperoxidase for diagnosis in solid organ transplant recipient patients
Provedor de dados: 55
Autores: Carraro,Emerson; Pasternak,Jacyr; Perosa,Ana; Siqueira,Itacy; Martino,Marines Dalla Vale.
Cytomegalovirus (CMV) antigenemia is still one of the two major assays available for diagnosis and monitoring of CMV infections. A commercial rapid test recently available in Brazil for quantification of human cytomegalovirus pp65 antigenemia revealed by immunofluorescence technique was compared with the original in-house method revealed by immunoperoxidase in patients receiving solid organ transplants. Of 80 blood samples tested for CMV antigenemia, 34 (42.5%) were positive: commercial assay detected 33 (97%) and in-house assay detected 20 (58.8%) samples. The numbers of positive cells in the two assays were different, with a median of 4.5 and 12 positive cells obtained by in-house and commercial kit, respectively. Discrepancies between assays occurred in...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cytomegalovirus; Antigenemia assay; Immmunoperoxidase; Immunofluorescence.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300023

Comparison of clinical and laboratory characteristics between children and adults with dengue
Provedor de dados: 55
Autores: Souza,Luiz José de; Pessanha,Laís Bastos; Mansur,Laura Carvalho; Souza,Luiza Assed de; Ribeiro,Mariana Barbosa Tâmega; Silveira,Monique do Vale da; Souto Filho,João Tadeu Damian.
Over the past several years, the epidemiological profile of dengue has been changing progressively and is currently characterized by an increase in the number of cases in children under 15 years of age. This study was aimed at comparing the clinical and laboratory features between adults and children with dengue; therefore, we performed a cross-sectional analysis of 5686 individuals with laboratory-confirmed dengue who sought treatment at a healthcare facility in Rio de Janeiro, Brazil from 2010 to 2011. A multivariate analysis indicated that myalgia (OR = 2.58; CI 95% = 2.08-3.18), retro-orbital pain (OR = 1.36; CI 95% = 1.15-1.62), nausea (OR = 1.92; CI 95% = 1.60-2.30), and arthralgia (OR = 3.64; CI 95% = 2.72-4.89) were the most frequent clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Dengue fever; Clinical spectra; Epidemiology.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100005

Comparison of clinical characteristics between healthcare-associated pneumonia and community-acquired pneumonia in patients admitted to secondary hospitals
Provedor de dados: 55
Autores: Lee,Jong Hoo; Kim,Yee Hyung.
BACKGROUND: Since healthcare-associated pneumonia (HCAP) is heterogeneous, clinical characteristics and outcomes are different from region to region. There can also be differences between HCAP patients hospitalized in secondary or tertiary hospitals. This study aimed to evaluate the clinical characteristics of HCAP patients admitted into secondary community hospitals. METHODS: This was a retrospective study conducted in patients with HCAP or community-acquired pneumonia (CAP) hospitalized in two secondary hospitals between March 2009 and January 2011. RESULTS: Of a total of 303 patients, 96 (31.7%) had HCAP. 42 patients (43.7%) resided in a nursing home or long-term care facility, 36 (37.5%) were hospitalized in an acute care hospital for &amp;gt; 2 days...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Health care; Pneumonia; Antibiotics; Mortality; Resistance.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400002

Comparison of conventional methods for diagnosis of visceral leishmaniasis in children of the Center-West Region of Brazil
Provedor de dados: 55
Autores: Brustoloni,Yvone M.; Cunha,Rivaldo V.; Dorval,Maria Elizabeth; Oshiro,Elisa T.; Pontes,Elenir R.J.C.; Oliveira,Ana Lúcia L.; Hillebrand,Lilian; Ribeiro,Luis Felipe.
In Brazil, sophisticated techniques currently employed for diagnosis of visceral leishmaniasis, such as polymerase chain reaction-based assays, are only available in major research centers, whereas conventional methods are still used in many areas where the disease occurs. In the state of Mato Grosso do Sul, in the country's Center-West Region, visceral leishmaniasis has recently emerged in many cities, and duration of the disease, from the onset of symptoms to diagnosis, has been short. Considering that results of diagnostic tests may depend on the phase of the disease, we compared direct examination of bone marrow aspirates (BMAs), BMA culture, and serology by Indirect Immunofluorescence Antibody Test (IFAT) for diagnosis in children, according to time...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; Kala-azar; Diagnosis; Direct microscopy; Immunological tests.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100023

Comparison of different antibiotic protocols for asymptomatic bacteriuria in patients with neurogenic bladder treated with botulinum toxin A
Provedor de dados: 55
Autores: Paradella,Ana Claudia; Musegante,André Ferraz de Arruda; Brites,Carlos.
ABSTRACT Intravesical botulinum toxin A (BoNTA) injection has been widely used for the treatment of detrusor overactivity in patients with neurogenic bladder due to spinal cord injury who do not respond to conventional treatment. There is no consensus about antibiotic prophylaxis for this procedure. We conducted a retrospective analysis of medical records of adult patients with spinal cord injury who underwent detrusor BoNTA injection between January of 2007 and December of 2013 in a rehabilitation hospital. Occurrence of symptomatic urinary tract infection (UTI) was assessed in 3 groups in accordance with their use of antibiotics (prophylactic dosage, 3 days, more than 3 days) for the treatment of asymptomatic bacteriuria. All patients were performing...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Botulinum toxin; Type A Urinary tract infections Bacteriuria Antibiotic prophylaxis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600623

Comparison of different primes for PCR-based diagnosis of cutaneous leishmaniasis
Provedor de dados: 55
Autores: Oliveira,Diego Molina de; Lonardoni,Maria Valdrinez Campana; Teodoro,Ueslei; Silveira,Thais Gomes Verzignassi.
OBJECTIVE: The objective of this study was to analyze different primers that are commonly used in epidemiological studies for the detection of Leishmania DNA by PCR, and to compare them to the conventional direct parasite search for American cutaneous leishmaniasis (ACL) diagnosis. MATERIAL AND METHODS: Five pairs of primers, four of them derived from Leishmania kDNA sequences (MP3H-MP1L; B1-B2; LBF1-LBR1; 13A-13B), and one derived from the SL RNA (mini-exon) gene repeat (LU5A-LB3C), reported previously, were used. RESULTS: The MP3H-MP1L primers were the best at amplifying the DNA, detecting 2 fg of Leishmania spp. DNA. The 13A-13B primers presented the worst performance, detecting 512 x 10³ fg of DNA. CONCLUSION: The wide variation in the analytical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmaniasis; Polymerase chain reaction; Leishmania; DNA primers.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300004

Comparison of dot-ELISA and standard ELISA for detection of Neisseria meningitidis outer membrane complex-specific antibodies
Provedor de dados: 55
Autores: Belo,Elza FT; Farhat,Calil K; Gaspari,Elizabeth N De.
Dot-ELISA using the outer membrane complex antigens of Neisseria meningitidis as a target was standardized for rapid detection of meningococcal-specific antibodies in human serum. We investigated the level of meningococcal-specific IgG, IgA, and IgM in serum using dot-ELISA with outer membrane antigens prepared from Neisseria meningitidis serotype B:4.19:P1.15,3,7,9 (a strain isolated from a Brazilian epidemic). The dot-ELISA is based on the same principles as the standard ELISA and is useful for detection of anti-N. meningitidis B antibodies in serum of patients with meningococcal infections. For the assay, outer membrane complexes (OMCs) were absorbed by nitrocellulose membrane and blocked with a 5% skim milk solution. Serum samples were drawn upon...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Dot-ELISA; ELISA; Antibodies; Outer membrane complex.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100008

Comparison of entecavir and adefovir for the treatment of chronic hepatitis B
Provedor de dados: 55
Autores: Zhao,Si-Hai; Liu,En-Qi; Cheng,Da-Xin; Li,Ya-Feng; Wang,Yan-Li; Chen,Yu-Long; Sun,Wen-Tao; Yan,Xi-Cai; Dang,Shuang-Suo.
The results of several new clinical trials that compared the effectiveness of entecavir (ETV) treatment with that of adefovir (ADV) treatment in patients with chronic hepatitis B (CHB) were published in recent years. However, the numbers of patients included in these clinical trials were too small to draw a clear conclusion as to whether ETV is more effective than ADV. Therefore, a new meta-analysis was needed to compare ETV with ADV for the treatment of CHB. A search of the Cochrane Central Register of Controlled Trials (CCTR), MEDLINE, the Science Citation Index, Embase, the China National Knowledge Infrastructure (CNKI), and the Wanfang Database for relevant studies published between 1966 and 2010 was performed. Trials comparing the use of ETV and ADV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Entecavir; Adefovir; Hepatitis B.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400010

Comparison of four extraction methods to detect hepatitis A virus RNA in serum and stool samples
Provedor de dados: 55
Autores: Paula,Vanessa Salete de; Villar,Livia Melo; Gaspar,Ana Maria Coimbra.
The efficiency of extraction methods for hepatitis A virus (HAV) RNA in clinical samples is of great importance for molecular diagnosis, especially in regions endemic for HAV, such as Brazil. We compared the efficiency of four different extraction techniques in serum and stool samples for the detection of hepatitis A virus by reverse transcription PCR (RT-PCR). We used PCR to analyse serum and stool samples of 12 patients who were referred to the Brazilian Reference Center for Viral Hepatitis (BRCVH) in Rio de Janeiro. The methods tested were Proteinase K, Silica, TRIzol and Guanidine isothiocyanate. Proteinase K extraction was the best method for serum samples; it detected the HAV-RNA in 11 of the 12 samples. The guanidine isothiocyanate method was the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HAV; Extraction methods; Serum and stool; RT-PCR.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200007

Comparison of immunoperoxidase and immunofluorescence assays for pp65 cytomegalovirus antigen in immunocompromised patients
Provedor de dados: 55
Autores: Debur,Maria do Carmo; Vidal,Luine R. Rosele; Nogueira,Meri Bordignon; Pereira,Luciane Aparecida; Takahashi,Gislene R.A.; Rotta,Indianara; Almeida,Sérgio Monteiro de; Raboni,Sonia Mara.
We compared the pp65 antigen detection by an in house method (immunoperoxidase assay) and by a commercial kit (immunofluorescence assay) available for cytomegalovirus infection diagnosis in immunocompromised patients. Sixty-four blood samples were analyzed in duplicate for both techniques. Eight-six percent of the samples had concordant qualitative results. The discordant results occurred more frequently in samples with low quantity of positive cells. There were no significant differences with qualitative and quantitative results of the methods.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Immunoperoxidase; Immunofluorescence; Cytomegalovirus; Immunocompromised patients; Bone marrow transplantation; Solid organ transplant.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200014

Comparison of multiplex PCR with serogrouping and PCR-RFLP of fliC gene for the detection of enteropathogenic Escherichia coli (EPEC)
Provedor de dados: 55
Autores: Bouzari,Saeid; Aslani,Mohammad M; Oloomi,Mana; Jafari,Anis; Dashti,Amir.
Enteropathogenic Escherichia coli (EPEC) comprise one of the six categories of diarrhoeagenic E. coli (DEC). EPEC is subgrouped into typical (tEPEC) and atypical (aEPEC). The identification of DEC cannot be based only on cultural and biochemical criteria, since they are indistinguishable from the non-pathogenic E. coli commonly found in human feces. Several PCR methods, with both single and multiple target genes, have been reported for detecting the different DEC pathotypes. In the present study five hundred E. coli isolates from children with diarrhea were subjected into multiplex PCR. Furthermore the strains were typed serologically with O antisera and their fliC gene was characterized by PCR-RFLP. The results obtained revealed that overall 41 (8.2%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Enteropathogenic Escherichia coli; Polymerase chain reaction.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400011

Comparison of multiplex-PCR and antigen detection for differential diagnosis of Entamoeba histolytica
Provedor de dados: 55
Autores: Santos,Helena Lúcia Carneiro; Peralta,Regina Helena Saramago; Macedo,Heloisa Werneck de; Barreto,Magali Gonçalves Muniz; Peralta,José Mauro.
Amebiasis is an infection caused by Entamoeba histolytica. However, differentiation between E. histolytica and Entamoeba dispar, which are morphologically identical species, is essential for treatment decision, precaution of the invasive disease and public health. The purpose of the present study was to evaluate a Multiplex -PCR for detection and differentiation of E. histolytica from E. dispar from fresh stool samples in comparison with the coproantigen commercial ELISA. Microscopic examination of stools using the Coprotest method, detection of stool antigen by enzyme-linked immunosorbent assay kit and a home made Multiplex-PCR, were used for the diagnosis of amoebiasis infection. Analysis of the 127 stools samples by microscopy examination demonstrated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multiplex-PCR; Entamoeba histolytica; Amebiasis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300013

Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples
Provedor de dados: 55
Autores: de Filippis,Ivano; Andrade,Claudia Ferreira de; Caldeira,Nathalia; Azevedo,Aline Carvalho de; Almeida,Antonio Eugenio de.
Abstract  Background Several in-house PCR-based assays have been described for the detection of bacterial meningitis caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae from clinical samples. PCR-based methods targeting different bacterial genes are frequently used by different laboratories worldwide, but no standard method has ever been established. The aim of our study was to compare different in-house and a commercial PCR-based tests for the detection of bacterial pathogens causing meningitis and invasive disease in humans.  Methods A total of 110 isolates and 134 clinical samples (99 cerebrospinal fluid and 35 blood samples) collected from suspected cases of invasive disease were analyzed. Specific sets of primers...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diagnostic; Neisseria meningitidis; Streptococcus pneumoniae; Haemophilus influenzae.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400335

Comparison of PCR-based molecular markers for the characterization of Proteus mirabilis clinical isolates
Provedor de dados: 55
Autores: Michelim,Lessandra; Muller,Gabriela; Zacaria,Jucimar; Delamare,Ana Paula Longaray; Costa,Sérgio Olavo Pinto da; Echeverrigaray,Sergio.
Proteus mirabilis is one of the most important pathogens associated with complicated urinary tract infections (acute pyelonephritis, bladder infections, kidney stones) and bacteremia, affecting patients with anatomical abnormalities, immunodeficiency, and long-term urinary catheterization. For epidemiological purposes, various molecular typing methods, such as pulse-field gel electrophoresis (PFGE) or ribotyping, have been developed for this pathogen. However, these methods are labor intensive and time-consuming. We evaluated the discriminatory power of several PCR-based fingerprinting methods (RAPD, ISSR, ERIC-PCR, BOX-PCR and rep-PCR) for P. mirabilis clinical isolates. Typing patterns and clustering analysis indicated that RAPD, BOX-PCR and ERIC-PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Proteus mirabilis; Molecular markers; Fingerprinting; PCR.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500014

Comparison of serological and parasitological methods for cutaneous leishmaniasis diagnosis in the state of Paraná, Brazil
Provedor de dados: 55
Autores: Szargiki,Regiane; Castro,Edilene Alcântara de; Luz,Ennio; Kowalthuk,Wolodymir; Machado,Ângela Maria; Thomaz-Soccol,Vanete.
We evaluated the effectiveness of serological and parasitological methods for cutaneous leishmaniasis (CL) diagnosis in patients from the central region of Paraná state, southern Brazil. Five groups were compared: clinical diagnosis, parasitological diagnosis, communicants, inhabitants of a non-endemic area and carriers of other etiologies. Two antigens were prepared from promastigotes of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis for indirect immunofluorescence assay, ELISA and immunoblotting. The parasitological approaches detected 79.3% of the patients with a clinical diagnosis; the parasites were identified by PCR as L. (V.) braziliensis. Serological methods showed 95% sensitivity for homologous antigens. Immunoblotting...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cutaneous leishmaniasis; Immunodiagnosis; Antigen; Western blotting.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100011

Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Dias,Fernanda Rezende; Bressan,Flavia Feres; Santos,Carolina Rocio Oliveira.
ABSTRACT The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0.845; p &lt; 0.000). Only 26.1% were classified as cardiovascular high risk by Framingham compared to 46% by ACC/AHA score (Kappa = 0.745; p &lt; 0.039). Only one out of eight...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; HIV; Co-morbidities; Non-AIDS events.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600577

Complete substitution of the Brazilian endemic clone by other methicillin-resistant Staphylococcus aureus lineages in two public hospitals in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Chamon,Raiane Cardoso; Ribeiro,Sthefanie da Silva; Costa,Thaina Miranda da; Nouér,Simone Aranha; Santos,Katia Regina Netto dos.
Abstract Staphylococcus aureus is an important cause of bloodstream infections. Therefore, the main purpose of this work was to characterize a collection of 139 S. aureus isolates from bloodstream infections in two public hospitals in relation to their antimicrobial susceptibility profile, staphylococcal cassette chromosome mec types, and clonal relationship. Methicillin resistance and resistance to other 12 agents were accessed by the disk diffusion test. Minimum inhibitory concentration to mupirocin was also determined. The SCCmec types were accessed by multiplex PCR, and the clonal relationship was determined by pulsed field gel electrophoresis method and restriction modification system characterization. Besides, multilocus sequence typing was performed...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Staphylococcus aureus; Bloodstream infections; USA100; Mupirocin resistance.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200185

Compliance to antiretroviral medication as reported by AIDS patients assisted at the University Hospital of the Federal University of Mato Grosso do Sul
Provedor de dados: 55
Autores: Monreal,Maria Tereza Ferreira Duenhas; Cunha,Rivaldo Venâncio da; Trinca,Luzia Aparecida.
Compliance to antiretroviral medication is a problem for AIDS patients. Compliance can be influenced by the characteristics of the therapeutic program, by the health guidance professionals, by the patient, and by society in general. A group of 139 Brazilian AIDS patients from the Infectious-Parasitic Diseases day clinic at the University Hospital of the Federal University of Mato Grosso do Sul were interviewed from September 27, 1999 to January 21, 2000. We identified and evaluated the frequency of noncompliance to antiretroviral medication, as well as the associated motives. Those who ingested 80%, or more, of prescribed dosages during the week previous to the interview were considered compliant. Among the patients interviewed, 70% mentioned loss or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Compliance; Antiretroviral.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100002

Compliance with handwashing at two intensive care units in São Paulo
Provedor de dados: 55
Autores: Furtado,Guilherme H.C.; Santana,Solange L.; Coutinho,Ana Paula; Perdiz,Luciana B.; Wey,Sérgio B.; Medeiros,Eduardo A.S.
Handwashing compliance was compared at two medical- surgical intensive care units (ICUs) of a teaching and a non-teaching hospital. The mean compliance was 22.2% and 42.6%, respectively. Respiratory therapists at the non-teaching hospital had the best handwashing compliance (52.6%). Nursing assistants at the teaching hospital had the worst compliance (11.5%). Nursing assistant was the only health-care worker category with a significant difference between the two ICUs (odds ratio = 6.0; 95% confidence interval = 3.83-9.43; p&lt; 0.001).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Compliance; Handwashing; Healthcare workers; Intensive care.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100007

Compositional changes of PBL population in patients with chronic hepatitis B virus infection
Provedor de dados: 55
Autores: Alireza,Khabiri; Mohsen,Abolhassani; Sudabeh,Aslani; Hiedeh,Darabi; Farideh,Bagheri; Mohammad-Hossein,Alimohammadian.
In this report we have analysed the peripheral blood lymphocyte of several patients with chronic hepatitis B virus infection with flow cytometry. Based on the presence and absence of the HBeAb, patients were divided into two groups. In both, all the patients were HBsAg positive with normal range of serum alanine aminotranferase (23.9 ± 17.8). We have found that the immunophenotypic profiles of patients were different from healthy donors with significant decrease in CD3+ T cells, specially CD8+ T cells and a siginificant increase in the CD19+ B cells. The differences were seen in other subset of T cells (CD4+) or NK cells (CD56+/CD16+ ) and HLA-DR markers were not significant. When the phenotypic profiles of both groups were compared with each other, such...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Chronic HBV infection; HBsAg; HBeAg; HBeAb; Lymphocyte subset; Flow cytometry.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600009

Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis
Provedor de dados: 55
Autores: Uchoa,Breno Kristoffer Beleza; Albério,Carlos Augusto Abreu; Pinto,Ana Carla Godinho; Lucena,Stefania de Medeiros Araujo; Vieira,José Luiz Fernandes.
ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 µg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) µg/mL, 0.55 (0.5) µg/mL and 0.46 (0.4) µg/mL. There was a high variation of rifampicin levels...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Infectious disease; Tuberculosis; Rifampicin.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200130

Concomitant prostatic schistosomiasis and sdenocarcinoma: case report and review
Provedor de dados: 55
Autores: Basílio-de-Oliveira,Carlos Alberto; Aquino,Armando; Simon,Eliane Francine; Eyer-Silva,Walter A.
The term schistosomiasis encompasses a group of infectious disorders caused by five species of the genus Schistosoma, a blood trematode of outstanding importance in tropical areas. Some of these disorders have long been associated with malignant neoplasia, the most striking association being between disease caused by Schistosoma haematobium, the predominant etiological agent of urinary schistosomiasis, and squamous cell carcinoma of the bladder, a relatively uncommon vesical cancer in non-endemic areas. Four cases of simultaneous adenocarcinoma and schistosomiasis of the prostate have been previously reported (S. haematobium in three and S. mansoni in one). We report a fifth case of concomitant adenocarcinoma and schistosomiasis of the prostate in a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adenocarcinoma; Prostate; Schistosomiasis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100007

Conference: Abstract
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100015

Congenital toxoplasmosis in a reference center of Paraná, Southern Brazil
Provedor de dados: 55
Autores: Capobiango,Jaqueline Dario; Breganó,Regina Mitsuka; Navarro,Italmar Teodorico; Rezende Neto,Claudio Pereira; Casella,Antônio Marcelo Barbante; Mori,Fabiana Maria Ruiz Lopes; Pagliari,Sthefany; Inoue,Inácio Teruo; Reiche,Edna Maria Vissoci.
This study describes the characteristics of 31 children with congenital toxoplasmosis children admitted to the University Hospital of Londrina, Southern Brazil, from 2000 to 2010. In total, 23 (85.2%) of the mothers received prenatal care but only four (13.0%) were treated for toxoplasmosis. Birth weight was &lt;2500 g in 37.9% of the infants. During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or splenomegaly (62.1%), jaundice (13.8%), and microcephaly (6.9%). During ophthalmic examination, 74.2% of the children exhibited injuries, 58.1% chorioretinitis, 32.3% strabismus, 19.4% microphthalmia, and 16.2% vitreitis. Anti-Toxoplasma gondii IgM...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasma gondii; Congenital toxoplasmosis; Chorioretinitis; Diagnosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400364

Congenital toxoplasmosis infection in an infant born to an HIV-1-infected mother
Provedor de dados: 55
Autores: Cruz,Maria Letícia Santos; Cardoso,Claudete Araújo; Saavedra,Mariza C.; Santos,Eliane dos; Melino,Tatiana.
We report the occurrence of congenital toxoplasmosis in an infant born to an HIV infected mother who had high anti-toxoplasma IgG and negative IgM at nine weeks of gestation. We briefly review available literature and discuss the possible mechanisms of transmission of congenital toxoplasmosis among HIV infected pregnant women.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital toxoplasmosis; HIV-1 exposed infants; Avidity test.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600017

Congenital toxoplasmosis: public health policy concerns
Provedor de dados: 55
Autores: Vanni,Tazio; Ribeiro,Rodrigo A.; Varella,Ivana S.; Polanczyk,Carisi A.; Fonseca,Benedito A. L.; Kuchenbecker,Ricardo.
Tipo: Info:eu-repo/semantics/other
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200002

Congenital toxoplasmosis transmitted by human immunodeficiency-virus infected women
Provedor de dados: 55
Autores: Azevedo,Kátia Martins Lopes de; Setúbal,Sérgio; Lopes,Vania Gloria Silami; Camacho,Luiz Antônio Bastos; Oliveira,Solange Artimos de.
We report the occurrence of congenital toxoplasmosis in three infants born to HIV infected women who had high anti-toxoplasma IgG and negative IgM during pregnancy. We briefly reviewed available literature and discussed the possible transmission mechanisms of congenital toxoplasmosis among HIV infected pregnant women. Serum samples were tested for Toxoplasma gondii IgM and IgG antibodies using commercial enzyme immunoassay and IgG-avidity tests. In the first case, fetal death occurred at 28th week of gestation. In the second case, congenital toxoplasmosis was diagnosis at 6th month of life; and in the third case, an HIV-infected newborn, congenital toxoplasmosis was asymptomatic. These cases point out to the possibility of enhanced maternal-fetal...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Congenital toxoplasmosis; Human immunodeficiency-virus; Prevention; AIDS.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200014

Congenital tuberculosis: a case report
Provedor de dados: 55
Autores: Vilarinho,Liana Consuelo Santana.
Congenital tubercolosis is an unusual and severe clinical pattern of tuberculosis presentation of Mycobacterium tuberculosis infection. Furthermore, it usually has a difficult treatment. We report a two-month-old male infant who presented with fever, dyspnea and a diffuse micronodular pattern at x-ray; mother with severe tuberculosis. Treatment with the triple drug regimen was initiated, but the child developed jaundice and an increase in liver enzymes on various occasions during treatment. A regimen specifically developed for cases of intolerance was initiated but there was no improvement in hyperthermia. Finally, the dose of INH and RMP was increased, the fever receded and the child was cured. This case remarks difficulties on diagnosis and therapeutic...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; Congenital; Antituberculosis medication; Mycobacterium.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500014

Congenitally transmitted visceral leishmaniasis: report of two brazilian human cases
Provedor de dados: 55
Autores: Mescouto-Borges,Myrlena Regina Machado; Maués,Érika; Costa,Dorcas Lamounier; Pranchevicius,Maria Cristina da Silva; Romero,Gustavo Adolfo Sierra.
Visceral leishmaniasis is a relevant public health problem worldwide. Most of the reported cases in Latin America are from Brazil. Herein we report two human cases of congenitally transmitted visceral leishmaniasis in two patients who developed symptoms during pregnancy. The diagnosis was made by visual examination of Leishmania parasites in bone marrow aspirates of the mothers and by detecting parasite kDNA in bone marrow samples of the newborn children using polymerase chain reaction.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Congenital transmission; Visceral leishmaniasis; Leishmania infantum; Pregnancy.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200024

Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma
Provedor de dados: 55
Autores: Arruda,Érico; Jacome,Alexandre Andrade dos Anjos; Toscano,Ana Luiza de Castro Conde; Silvestrini,Anderson Arantes; Rêgo,André Santa Bárbara; Wiermann,Evanius Garcia; Cunha Jr.,Geraldo Felicio da; Melo,Heloisa Ramos Lacerda de; Morejón,Mirna Loro; Goldani,Luciano Zubaran; Pereira Jr.,Luiz Carlos; Silva,Mariliza Henrique; Treistman,Mauro Sergio; Pereira,Mônica Cristina Toledo; Romero,Patricia Maria Bezerra Xavier; Schmerling,Rafael Aron; Guedes,Rodrigo Antonio Vieira; Camargo,Veridiana Pires de.
Kaposi's sarcoma is a multifocal vascular lesion of low-grade potential that is most often present in mucocutaneous sites and usually also affects lymph nodes and visceral organs. The condition may manifest through purplish lesions, flat or raised with an irregular shape, gastrointestinal bleeding due to lesions located in the digestive system, and dyspnea and hemoptysis associated with pulmonary lesions. In the early 1980s, the appearance of several cases of Kaposi's sarcoma in homosexual men was the first alarm about a newly identified epidemic, acquired immunodeficiency syndrome. In 1994, it was finally demonstrated that the presence of a herpes virus associated with Kaposi's sarcoma called HHV-8 or Kaposi's sarcoma herpes virus and its genetic sequence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kaposi's sarcoma; AIDS; Consensus; Cutaneous.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300315

Consensus of the Brazilian Society of Infectious Diseases on the management and treatment of hepatitis C
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de; Mendonça,João Silva; Barone,Antonio Alci; Gonçales Junior,Fernando Lopes; Ferreira,Marcelo Simão; Focaccia,Roberto; Pawlotsky,Jean-Michel.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500001

Consensus of the Brazilian Society of Infectious Diseases on the management and treatment of hepatitis C
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de; Mendonça,João Silva; Barone,Antonio Alci; Gonçales Junior,Fernando Lopes; Ferreira,Marcelo Simão; Focaccia,Roberto; Pawlotsky,Jean-Michel.
Tipo: Info:eu-repo/semantics/article
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700001

Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica
Provedor de dados: 55
Autores: Rushdy,Abeer Ahmed; Mabrouk,Mona Ibrahim; Abu-Sef,Ferialla Abdel-Hamid; Kheiralla,Zeinab Hassan; Abdel -All,Said Mohamed; Saleh,Neveen Mohamed.
OBJECTIVES: To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree of synergistic activity of efflux pump inhibitors when combined with ciprofloxacin against resistant isolates. METHODS: Antimicrobial resistance patterns of fifty-eight Salmonella isolates were tested. Five isolates were selected to study the mechanism of resistance associated with quinolone group, including mutation in topoisomerase-encoding gene, altered cell permeability, and expression of an active efflux system. In addition, the combination between antibiotics and efflux pump inhibitors to overcome the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella; Fluoroquinolone resistance; Efflux pump; Outer membrane protein; Chromosomal mutations.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400008

Control of multi-resistant bacteria and ventilator-associated pneumonia: is it possible with changes in antibiotics?
Provedor de dados: 55
Autores: Jukemura,Elisa M.; Burattini,Marcelo N.; Pereira,Carlos A.P.; Braga,Alfésio L.F.; Medeiros,Eduardo A.S.
Potent antimicrobial agents have been developed as a response to the development of antibiotic-resistant bacteria, which especially affect patients with prolonged hospitalization in Intensive Care Units (ICU) and who had been previously treated with antimicrobials, especially third-generation cephalosporins.This study was to determine how changes in the empirical treatment of infections in ICU patients affect the incidence of Gram-negative bacteria species and their susceptibility to antimicrobials, and examine the impact of these changes on nosocomial infections. A prospective interventional study was performed in a university hospital during two periods: 1) First period (September 1999 to February 2000); and 2) Second period (August 2000 to December...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator associated pneumonia; Multi-resistant bacteria; Infection control.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400010

Control of spread of microorganisms in the hospital - back to the basics of hand washing and glove use
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100008

Conventional serological performance in diagnosis of Chagas' disease in southern Brazil
Provedor de dados: 55
Autores: Araújo,Anelise Bergmann; Berne,Maria Elisabeth Aires.
Results of Chagas' disease diagnosis show disagreement. The aim of this study was to compare commercial tests for Chagas' disease serodiagnosis in southern Brazil. A total of 161 samples were evaluated. Three enzyme-linked immunosorbent assays, one indirect hemagglutination and one indirect immunofluorescence were assessed. Trypomastigote excreted-secreted antigen-blot was a confirmatory method. From 161 samples, 65.84% were positive in all tests, while 34.16% presents mismatch result in at least one of the tests. All techniques tested presented false-positive and/or false-negative results as follows: Enzyme-linked immunosorbent assay 1 had more false-positive results (lower specificity), indirect immunofluorescence had the highest rate of false-negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Chagas' disease; Serodiagnosis; Immunoassays.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200010

Coronaviruses in children with febrile neutropenia
Provedor de dados: 55
Autores: Alvares,Paula A.; Berezin,Eitan N.; Botelho,Andrea C.; Tiemi,Denise; Spinardi,Julia R.; Maruyama,Claudia; Bruniera,Paula; Passos,Saulo D.; Mimica,Marcelo J.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100098

Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil
Provedor de dados: 55
Autores: Módena,José Luiz Proença; Acrani,Gustavo Olszanski; Micas,André Fernando Ditondo; Castro,Marly de; Silveira,Wanderley Dias da; Módena,José Luiz Pimenta; Oliveira,Ricardo Brandt de; Brocchi,Marcelo.
Helicobacter pylori is considered a significant agent in the development of various gastric diseases. However, the diseases caused by this bacterium are known as being multi-factorial, with the genotype, immune system and life habits of the host playing important roles in the establishment of the clinical outcome. Also, H. pylori exhibit a high degree of genetic variability, contributing to the complexity of the host-pathogen relationship. These observations, considered together with the widely-varying origins and social habits of the Brazilian population, lead us to speculate about the influence of these life habits on H. pylori infection and the clinical outcome. Therefore, in this study we evaluated the relationship between H. pylori infection and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Duodenal ulcer; Gastric ulcer; Gastritis; Life habits.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100020

Correlation between Plasmodium vivax variants in Belém, Pará State, Brazil and symptoms and clearance of parasitaemia
Provedor de dados: 55
Autores: Machado,Ricardo Luiz Dantas; Figueiredo Filho,Alberto Ferreira de; Calvosa,Vanja Sueli Pachiano; Figueredo,Maria Cristina; Nascimento,José Maria; Póvoa,Marinete Marins.
The aim of this study was to determine how different types of P. vivax affect clinical symptoms and parasitaemia clearance. Blood was collected from individuals from Pará State, Brazil. The patients were treated as chloroquine plus primaquine. P. vivax were typed daily till D7 and again on D30. Now we can confirm a previously reported correlation between P. vivax genotype and response to chloroquine. Clinical symptoms do not allow for objective identification of different P. vivax types in the Brazilian Amazon, since the VK247 and P. vivax-like have only been detected in mixed infections.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Plasmodium vivax variants; Symptoms; Chloroquine and primaquine treatment; Clearence of parasitaemia.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300002

Correlation between serum tumor necrosis factor alpha levels and clinical severity of tuberculosis
Provedor de dados: 55
Autores: Andrade Júnior,Dahir Ramos de; Santos,Sânia Alves dos; Castro,Isac de; Andrade,Dahir Ramos de.
This study verified the correlation between the serum levels of TNF alpha and different clinical forms of tuberculosis. We described a group of 24 patients presenting several clinical forms of tuberculosis and a control group of 13 healthy individuals. The levels of TNF alpha were measured by bioassay method. The levels of TNF-alpha had significant differences between the tuberculosis and control groups. The patients with abnormal chest X-Ray findings had higher TNF alpha levels (15328.48 ± 4602.19 pg/mL) when compared to patients with normal X-Rays (3353.18 ± 1495.29 pg/mL) (p&lt;0.05). Patients that lost weight had higher TNF alpha levels (15468.54 ± 4580.54 pg/mL) than those that didn't loose weight (2904.98 ± 1367.89) (p&lt;0.05). The levels of TNF...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: TNF alpha; Tuberculosis; Cytokines; Clinical severity.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300013

Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India
Provedor de dados: 55
Autores: Kumaria,Rajni.
The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and elucidate the prognostic markers among four dengue serotypes, this study was conducted on 320 inpatients having acute febrile illness clinically suspected as DI, over a period of five years. Dengue serotypes were confirmed by multiplex reverse transcriptase (RT)-PCR. Eighty patients were positive for DI with presence of Den-1, Den-2, Den-3, and Den-4 in 8, 35, 27 and 10 patients, respectively. The severe clinical manifestations, abdominal pain and hepatomegaly,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue fever; Dengue infection; Serotype; Clinical spectra; Liver transaminase.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200005

Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population
Provedor de dados: 55
Autores: Wang,Changyuan; Wei,Li; Chu,Weilin; Yu,Haiyang; Yu,Xinjuan; Li,Chunxia.
ABSTRACT Host immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexual contact (NSC). In addition, 360 healthy volunteers were enrolled as controls. SNPs at positions −607C/A and −137G/C in IL-18 promoter were analyzed. Comparing CA patients to healthy controls, no dominant relevance was found between the IL-18 promoter −607 C/A or −137G/C polymorphisms and the CA disease either...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Condyloma acuminatum; Human papillomavirus; Cytokine; Single nucleotide polymorphism; IL-18.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388

Corrigendum in "Virus C genotype predisposes to primary hypothyroidism during interferon-α treatment for chronic hepatitis C"
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100027

Cost effectiveness of peginterferon alfa-2B combined with ribavirin for the treatment of chronic hepatitis C in Brazil
Provedor de dados: 55
Autores: Fonseca,Marcelo Cunio Machado; Araújo,Gabriela Tannus Branco de; Araújo,Denizar Vianna.
The treatment of chronic hepatitis C (CHC) with peginterferon alpha-2b/ribavirin (PegIFN + Rib) produced larger sustained viral response (SVR) compared to the conventional (non-pegylated) interferon/ribavirin (IFN + Rib), but its cost-effectiveness was not assessed in Brazil. We developed a Markov model to mirror the natural disease history and cohorts of patients with hepatitis C virus (HCV), that received PegIFN + Rib or IFN + Rib treatment for 48 or 24 weeks, according to viral genotype and liver histology. The SVRs for the treatments PegIFN + Rib and IFN + Rib were respectively 48% and 34% (genotype 1), and 88% and 80% (genotype non-1). Three Delphi panels were conducted with hepatologists and intensivists, and another one with oncologists. The costs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Cost-benefit analysis; Effectiveness; Interferons.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300007

Cost-effectiveness of entecavir versus lamivudine for the suppression of viral replication in chronic hepatitis B Patients in Brazil
Provedor de dados: 55
Autores: Costa,Anna Maria N.; L.'Italien,Gilbert; Nita,Marcelo Eidi; Araujo,Evaldo Stanislau A.
Hepatitis B virus infection is an important public-health issue. Chronic patients have a higher risk of death due to complications, which increases health-care expenses in. Cost-effectiveness analysis of entecavir (ETV) versus lamivudine (LVD) for treatment of chronic hepatitis B, in e antigen (AgHBe)-positive and negative patients, based on two phase 3, controlled and randomized studies. A decision analysis model was developed, using the following endpoints: cost per patient with undetectable viral load and cost per quality life year (QALY) gained. Risks for complications (compensated or decompensated cirrhosis and hepatocellular carcinoma) were based on the cohort study REVEAL, published in 2006. The REVEAL parameters were applied to the results of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Cost; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500005

Cost-effectiveness of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant staphylococcus aureus
Provedor de dados: 55
Autores: Machado,Adão R. L.; Arns,Clovis da Cunha; Follador,Wilson; Guerra,Aline.
Linezolid, an oxazolidinone-class antimicrobial agent, is a new drug; its use has frequently been questioned due to its high price. However, recent trials have demonstrated that the use of linezolid in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (VAP-MRSA) may be justified due to its improved efficacy compared to vancomycin. Price and cost have different magnitudes, and clinical efficacy should always be considered in the decision-making process. Our objective was to determine whether linezolid treatment was more cost-effective than vancomycin for treating VAP-MRSA. METHODOLOGY: Elaboration of an economic model from a metanalysis of previous clinical trials comparing both drugs, through a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Linezolid; Vancomycin; Staphylococcus aureus; Pneumonia; Ventilator; Cost; Pharmacoeconomic.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300001

Cost-effectiveness of telbivudine versus lamivudine for chronic hepatitis B
Provedor de dados: 55
Autores: Wiens,Astrid; Venson,Rafael; Correr,Cassyano Januário; Pontarolo,Roberto.
BACKGROUND AND AIM: Chronic hepatitis B is a highly prevalent disease worldwide, leading to serious consequences if not properly treated. Six treatment options for chronic hepatitis B are currently provided by the Brazilian public health system. Telbivudine is a nucleoside analogue that is neither included in the Brazilian clinical protocol nor in the therapeutic guidelines for chronic hepatitis B. OBJECTIVE: The aim of this study was to evaluate the cost-effectiveness of telbivudine for the viewpoint of the Brazilian public system, comparing it to lamivudine. METHODS: A Markov model was used to project lifetime complications and costs of treatment with lamivudine or telbivudine for chronic hepatitis B in both HBeAg-positive and HBeAg-negative patients. To...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lamivudine; Cost-effectiveness evaluation; Hepatitis B; Chronic.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300008

Cost-utility of quadrivalent versus trivalent influenza vaccine in Brazil – comparison of outcomes from different static model types
Provedor de dados: 55
Autores: Van Bellinghen,Laure-Anne; Marijam,Alen; de Araujo,Gabriela Tannus Branco; Gomez,Jorge; Van Vlaenderen,Ilse.
ABSTRACT  Background: Influenza burden in Brazil is considerable with 4.2–6.4 million cases in 2008 and influenza-like-illness responsible for 16.9% of hospitalizations. Cost-effectiveness of influenza vaccination may be assessed by different types of models, with limitations due to data availability, assumptions, and modelling approach.  Objective: To understand the impact of model complexity, the cost-utility of quadrivalent versus trivalent influenza vaccines in Brazil was estimated using three distinct models: a 1-year decision tree population model with three age groups (FLOU); a more detailed 1-year population model with five age groups (FLORA); and a more complex lifetime multi-cohort Markov model with nine age groups (FLORENCE).  Methods: Analysis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza; Brazil; Cost-effectiveness; Vaccination; QIV; TIV.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100001

Co-transmission of Rahnella aquatilis between hospitalized patients
Provedor de dados: 55
Autores: Martins,Willames; Carvalhaes,Cecília Godoy; Cayô,Rodrigo; Gales,Ana Cristina; Pignatari,Antonio Carlos.
ABSTRACT Rahnella aquatilis is an environmental Gram-negative bacillus that is rarely reported as human pathogen, being mainly associated with infections in immunocompromised patients. Herein we describe two cases ofR. aquatilis isolates recovered from endotracheal aspirate cultures of different patients in a tertiary hospital located in the city of São Paulo, Brazil. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rDNA gene sequencing were performed to confirm bacterial identification after the isolates being erroneously identified as Pantoea spp. by automated system. Both isolates showed the same PFGE pattern and presented the ß-lactamase encoding geneblaRAHN-1, responsible for resistance to cephalothin. The isolates...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Rahnella spp.; Bacteria identification; MALDI-TOF MS; Environmental bacteria.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600648

Cough and fear of sleep: early clinical signs of Bordetella pertussis in an adult
Provedor de dados: 55
Autores: Jones,Thomas C.; Gasser,Markus; Erb,Peter; Oechslin,Hanspeter.
Pertussis is increasing in frequency among adults, but early diagnosis requires special attention to details in the medical history. We describe a 64 year-old male with classic signs and symptoms of pertussis and documented Bordetella pertussis infection that were overlooked because he presented with a chief complaint of cough and fear of falling asleep. Coughing paroxysms and a feeling of suffocation (30-60 seconds) only occurred at night after short periods of deep sleep (30-45 minutes). The physicians did not observe these episodes during daytime examinations, and the basis of the patient's fear of sleep was not explored. We recommend reassessment of how adults describe symptoms of pertussis, including fear of sleep, and we suggest the use of PCR...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pertussis; Cough; Whooping cough; PCR technology.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400009

C-reactive protein in the diagnosis of community-acquired pneumonia
Provedor de dados: 55
Autores: Requejo,Henry I. Z.; Cocoza,Ana Maria.
Qualitative determination of C-reactive protein (CRP) was evaluated as a diagnostic method for community-acquired pneumonia. Paired serum and pleural fluid samples from child patients were examined with a CRP test, compared to bacterial cultures, counterimmunoelectrophoresis and immunoassay. The CRP test gave excellent parameters of sensitivity, specificity and predictive values for the diagnosis of bacterial pneumonia.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: C-reactive protein; Community-acquired pneumonia; Children.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400003

C-reactive protein-guided approach may shorten length of antimicrobial treatment of culture-proven late-onset sepsis: an intervention study
Provedor de dados: 55
Autores: Couto,Renato C.; Barbosa,José A. A.; Pedrosa,Tânia M.G.; Biscione,Fernando M.
Late-onset sepsis (LOS) (i.e., sepsis in a neonate after 72 hours of life) is associated with high mortality and significantly prolonged antibiotic exposure and hospital stay in neonates admitted to intensive care units (ICU). In this study, we assessed the reliability of serum C-reactive protein (CRP) as a determinant of antimicrobial treatment duration of LOS. From January 1996 to December 2002, all consecutive infants aged &lt;28 days admitted to a single medical-surgical ICU and diagnosed with primary LOS were enrolled in a prospective, intervention trial with historical controls. Only blood culture-positive LOSs were included. Exclusion criteria were: age &gt;28 days at diagnosis of LOS, development of site-specific infection, and central venous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: C-reactive protein; Newborn; Neonatal intensive care units; Sepsis; Antibiotics.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200015

Crusted scabies in a patient with lepromatous leprosy
Provedor de dados: 55
Autores: Pedra e Cal,Alexandra Peres Paim; Ferreira,Cassio Porto; da Costa Nery,José Augusto.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400399

Cryosurgery as adjuvant therapy in cutaneous sporotrichosis
Provedor de dados: 55
Autores: Ferreira,Cassio Porto; Galhardo,Maria Clara Gutierrez; Valle,Antônio Carlos Francescone do.
Tipo: Info:eu-repo/semantics/article
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200018

Cryptococcal meningitis in HIV-negative patient with liver cirrhosis due to hepatitis C
Provedor de dados: 55
Autores: Miranda,Érique José Peixoto de; Gonçalves,Luiz Guilherme; França,Francisco Oscar de Siqueira.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400019

Cryptococcus laurentii fungaemia in a cervical cancer patient
Provedor de dados: 55
Autores: Neves,Rejane Pereira; Lima Neto,Reginaldo Gonçalves de; Leite,Melyna Chaves; Silva,Vanessa Karina Alves da; Santos,Franz de Assis Graciano dos; Macêdo,Danielle Patrícia Cerqueira.
ABSTRACT Infections caused by emerging Cryptococcus non-neoformans species are being reported with increasingly frequency. Here, we present a case of fungaemia byCryptococcus laurentii in a woman receiving aggressive immunosuppressive therapy for cervical neoplasia. Three venous blood samples were aseptically collected on consecutive days and C. laurentiiwas isolated and identified through phenotypic and molecular methods. After central venous catheter removal and appropriate antifungal therapy, the patient showed significant improvement and blood culture became negative. Thus, patients following immunosuppressive therapies and using invasive medical devices are at risk of C. laurentii blood infections.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcus laurentii; Fungaemia; Cancer.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600660

CTX-M-producing Escherichia coli and Klebsiella pneumoniae isolated from community-acquired urinary tract infections in Valledupar, Colombia
Provedor de dados: 55
Autores: Martinez,Pedro; Garzón,Denisse; Mattar,Salim.
OBJECTIVE: Describe the presence of CTX-M-1 phylogenetic subgroup extended-spectrum i-lactamases (ESBL), associated with TEM and SHV genes, and the gene encoding cephalosporinase, CMY-2 in Escherichia coli and Klebsiella pneumoniae isolates from community-acquired urinary tract infections. METHODS: 102 E. coli and 21 K. pneumoniae were collected from patients with culture-proven urinary tract infection (UTI), during February and March, 2011. Antimicrobial susceptibility test was performed by disk diffusion according to the standards of the Clinical Laboratory Standard Institute. Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for blaTEM, blaSHV, blaCTX-M-1,-2,-8,-9, blaPER-2 and blaCMY-2 genes. Statistical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL; CTX-M; E. coli; K. pneumonia; Community-acquired UTIs; Colombia.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500003

Curb antimicrobial resistance: use the right antibiotic first!
Provedor de dados: 55
Autores: Pandey,Latika.
Tipo: Info:eu-repo/semantics/other
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500011

Current aspects of antibiotic prophylaxis for upper gastrointestinal bleeding in cirrhosis patients
Provedor de dados: 55
Autores: Almeida,Delvone; Paraná,Raymundo.
Bacterial infection is a common complication in cirrhotic patients. The portal hypertension as well as the immune depression observed in these patients can explain this high incidence of bacterial infection. Because of the high probability of cirrhotic patients to develop infections, antibiotic prophylaxis is warranted in some conditions, such as upper gastrointestinal bleeding or after spontaneous bacterial peritonitis. Nevertheless, antibiotic prophylaxis is not widely recommended for cirrhotic patients.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Antibiotic prophylaxis; Cirrhotics; Bacterial infections.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500009

Current status and recommendations on methicillin-resistant Staphylococcus aureus infection in Latin America
Provedor de dados: 55
Autores: Gotuzzo,Eduardo.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800002

Cut and puncture accidents involving health care workers exposed to biological materials
Provedor de dados: 55
Autores: Marino,Cristiane Grande Gimenez; El-Far,Fabiane; Wey,Sergio Barsanti; Medeiros,Eduardo A. Servolo.
The first report of occupational acquisition of HIV appeared in 1984, and, by June, 1997, the Centers for Disease Control and Prevention (CDC) had reported 52 documented cases of sero-conversion following occupational exposure to HIV-1 by health care workers of those cases. 47 (90.3%) were exposed to blood. The most frequent type of accident reported was percutaneous needlestick injury. Prospective studies have estimated that the risk of HIV transmission following percutaneous exposure to infected blood is 0.3% (Confidence Interval 95% = 0.2% to 0.5%). Following a mucous membrane exposure, the risk is 0.09% (CI 95% = 0.006% to 0.5%). The risk of hepatitis B acquisition ranges from 6% to 30%, and hepatitis C acquisition, 3% to 10%. Since 1992, the São Paulo...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV chemoprophylaxis; Occupational injuries; Needlestick injuries; Health care workers; Injuri prevention.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500001

Cutaneous cytomegalovirus infection in a child with hyper IgE and specific defects in antibody response to protein vaccines
Provedor de dados: 55
Autores: Fallah,Shahrzad; Tabatabaei,Ahmad; Pournasir,Zahra; Chavoshzadeh,Zahra; Rezaei,Nima.
Cytomegalovirus (CMV) infection is a common opportunistic systemic infection in immunocompromised patients, but skin involvement is rare. Herein, we report a 10 year-old girl from consanguineous parents who was referred to our center because of disseminated maculopapular rash. She had history of upper and lower respiratory tract infections. In immunological studies, increased serum IgE level and decreased responses to tetanus and diphtheria were detected. Polymerase chain reaction (PCR) examination of bronchoalveolar lavage and serum sample revealed the presence of CMV. Early diagnosis of cutaneous CMV and appropriate treatment are the key actions in management of patients with underlying immunodeficiencies to avoid further complications.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cytomegalovirus infections; Antibody formation; Common variable immunodeficiency.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500013

Cutaneous loxoscelism: extensive nonulcerated livedoid plaque
Provedor de dados: 55
Autores: Torres,Natalie; Rueda,Monica.
Tipo: Info:eu-repo/semantics/report
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300353

Cutaneous mucormycosis in advanced HIV disease
Provedor de dados: 55
Autores: Moreira,José; Ridolfi,Felipe; Almeida-Paes,Rodrigo; Varon,Andrea; Lamas,Cristiane C.
ABSTRACT Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy. The fungus was diagnosed on the basis of histopathology and culture. Our case emphasizes the need to consider mucormycosis in the differential diagnosis of necrotic cutaneous lesions in patients with late-stage HIV disease.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Mucormycosis; Rhizopus; AIDS.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600637

Cutaneous periumbilical purpura in disseminated strongyloidiasis in cancer patients: a pathognomonic feature of potentially lethal disease?
Provedor de dados: 55
Autores: Salluh,Jorge I. F.; Bozza,Fernando A.; Pinto,Tatiana S.; Toscano,Luisa; Weller,Peter F.; Soares,Marcio.
Cutaneous manifestations in disseminated strongyloidiasis are infrequent but should raise the suspicion for its diagnosis. We retrospectively evaluated the charts of six patients with cancer and a proven diagnosis of disseminated strongyloidiasis. All patients had received prophylaxis with albendazole before starting antineoplastic therapy, which included high-dose steroids. They presented with septic shock, acute respiratory failure and characteristic purpuric periumbilical skin lesions. Strongyloides larvae were identified in tracheal aspirates (n=5), gastric aspirates (n=4), lung (n=2) and skin biopsies (n=2). All patients died despite antihelminthic therapy and intensive care support.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Purpura; Cancer; Disseminated strongyloidiasis; Corticosteroids.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500010

Cytomegalovirus (CMV)-related cutaneous necrotizing vasculitis: case report and literature review
Provedor de dados: 55
Autores: Arslan,Ferhat; Batirel,Ayse; Mert,Ali; Ozer,Serdar.
Cytomegalovirus (CMV) infection is usually asymptomatic in immunocompetent patients. A mononucleosis-like syndrome may develop in some patients. Various organ involvements (eg: encephalitis, meningitis, retinitis, myocarditis, pneumonia, hepatitis, enterocolitis, neuritis), which rarely occur in immunocompetent patients, have also been reported. Cutaneous necrotizing vasculitis caused by CMV infection has been reported very rarely in the literature. Here, a case with a very rare clinical form of CMV infection, presenting with persistent fever and livedo reticularis on the extremities and cutaneous necrotizing vasculitis of the toes, is described, and the relevant literature is reviewed. This case report aims to highlight the possibility of CMV infection to...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cytomegalovirus; Vasculitis; Cutaneous.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500015

Cytotoxic factor secreted by Escherichia coli associated with sepsis facilitates transcytosis through human umbilical vein endothelial cell monolayers
Provedor de dados: 55
Autores: Tibo,Luiz Henrique Soares; Bertol,Jéssica Wildgrube; Bernedo-Navarro,Robert Alvin; Yano,Tomomasa.
Abstract Culture supernatant of sepsis-associated Escherichia coli (SEPEC) isolated from patients with sepsis caused loss of intercellular junctions and elongation of human umbilical vein endothelial cells (HUVEC). The cytotoxic factor was purified from culture supernatant of SEPEC 15 (serogroup O153) by liquid chromatography process. PAGE (polyacrylamide gel electrophoresis) showed that the purified SEPEC cytotoxic factor had a molecular mass of ∼150 kDa and consisted of at least two subunits. At the concentration of 1 CD50 (40 μg/mL) did facilitate transcytosis through the HUVEC cells monolayer of SEPEC 15 as much as E. coli K12 within 30 min without affecting cell viability. These results suggest that this cytotoxic factor, named as SPF (SEPEC's...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cytotoxin (SPF); Sepsis; Transcytosis; Transendothelial electrical resistance.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300014

Danger in the streets: exposures to bloodborne pathogens after community sharp injuries in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Costa,Marcellus Dias; Rapparini,Cristiane; Schmaltz,Carolina Arana Stanis; Tuyama,Mari; Lauria,Lilian de Mello; Saraceni,Valeria; Barroso,Paulo Feijó.
ABSTRACT  Objective: Exposures to sharps injuries occurring in the community are relatively frequent. We describe characteristics of community sharp exposures reported in the city of Rio de Janeiro from 1997 to 2010.  Methods: A cross-sectional analysis of exposure reports to sharps in the community reported to a surveillance system, designed for health care workers, of the Municipal Health Department of Rio de Janeiro. The characteristics of exposed individuals analyzed included types of exposure, the circumstances of the accident, and the prophylaxis offered.  Results: 582 exposures were studied. Median age was 30 years and 83 (14%) involved children with less than 10 years of age. Two hundred and seventeen (37%) occurred with sharps found in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Needlestick; Bloodborne; HIV; Hepatitis; Medical waste; Sharp injuries; Postexposure prophylaxis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300306

Dapsone syndrome with acute renal failure during leprosy treatment: case report
Provedor de dados: 55
Autores: Alves-Rodrigues,Edson Nogueira; Ribeiro,Luciano Correa; Silva,Margareth Dióz; Takiuchi,Arley; Fontes,Cor Jesus Fernandes.
Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Leprosy; Dapsone syndrome; Acute renal failure.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100014

Daptomycin and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus clonal lineages from bloodstream infection in a Brazilian teaching hospital
Provedor de dados: 55
Autores: Damasco,Andreia Paredes; Costa,Thaina Miranda da; Morgado,Priscylla Guimarães Migueres; Guimarães,Lorrayne Cardoso; Cavalcante,Fernanda Sampaio; Nouér,Simone Aranha; Santos,Kátia Regina Netto dos.
ABSTRACT  Introduction: This study aimed to characterize Staphylococcus aureus isolates from bloodstream infections in patients attending a teaching hospital, between 2011 and 2015.  Methods: The minimum inhibitory concentration for daptomycin, linezolid, oxacillin, teicoplanin, vancomycin, and trimethoprim/sulfamethoxazole was accessed by broth microdilution. SCCmec type and clonal profile were determined by molecular tests. Vancomycin heteroresistance was evaluated using screening tests and by population analysis profile/area under the curve.  Results: Among 200 S. aureus isolates, 55 (27.5%) were MRSA, carrying SCCmec II (45.5%) or IV (54.5%). The most frequent MRSA lineages were USA100 (ST5-II) (45.5%) and USA800 (ST5-IV) (30.9%). Six isolates were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bloodstream infection; S. aureus; Vancomycin; Daptomycin.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200139

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review
Provedor de dados: 55
Autores: Telles,João Paulo; Cieslinski,Juliette; Tuon,Felipe Francisco.
ABSTRACT  Backgroud: Daptomycin has been used in bone and joint infections (BJI) and prosthesis joint infections (PJI) considering spectrum of activity and biofilm penetration. However, the current experience is based on case reports, case series, cohorts, and international surveys. The aim of this systematic review was to evaluate studies about daptomycin treatment efficacy in BJI/PJI compared to other antibiotic regimens.  Methods: PubMed, LILACS, Scielo and Web of Science databases were searched for articles about daptomycin and treatment of BJI and PJI from inception to March 2018. Inclusion criteria were any published researches that included patients with BJI treated with daptomycin. Diagnosis of BJI was based on clinical, laboratory and radiological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Daptomycin; Staphylococcus aureus; Osteomyelitis; Joint infection; Arthritis.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300191

Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis: case report and literature review
Provedor de dados: 55
Autores: Rosa,Daniela Dornelles; Pasqualotto,Alessandro C.; Quadros,Maurício de; Prezzi,Sérgio Henrique.
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Meningococcal disease; Neisseria meningitidis; Complement deficiency.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400010

Definition of a diagnostic routine in individuals with inconclusive serology for chagas disease
Provedor de dados: 55
Autores: Picka,Mariele Cristina Modolo; Meira,Domingos Alves; Carvalho,Thaís Batista de; Peresi,Eliana; Marcondes-Machado,Jussara.
Despite the existence of highly sensitive tests, inconclusive serological results are frequent in chronic chagasic infection. This study aimed to define a diagnostic conduct for 30 individuals with inconclusive serology (G3) for chagasic infection assisted at the Outpatient Unit for Infectious and Parasitic Diseases of the Botucatu School of Medicine. Twenty-one individuals with negative serology (G1) and 33 with positive serology (G2) were also studied. Serological methods ELISA, HAI, IFI and immunoblotting TESA-cruzi were used for G1, G2 and G3, and parasitological methods xenodiagnosis, hemoculture and PCR-LIT were used for G2 and G3 individuals. ELISA, HAI and IFI were performed in 5 different blood samples in G2 and G3. TESA-cruzi was carried out only...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic chagasic infection; Trypanosoma cruzi; Inconclusive serology; Immunoblotting.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200012

Delayed diagnosis of multibacillary leprosy: a report of eight cases
Provedor de dados: 55
Autores: Trindade,Maria Angela Bianconcini; Varella,Tatiana Cristina Nogueira; Cisneros,Claudia Gertrudis Cardoza; Bottini,Vanessa; Moura,Ana Karina Alves.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200017

Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
Provedor de dados: 55
Autores: Focaccia,R.; Baraldo,D.C.M.; Ferraz,M.L.G.; Martinelli,A.L.C.; Carrilho,F.J.; Gonçales Jr.,F.L.; Pedroso,M.L.A.; Coelho,H.S.M.; Lacerda,M.A.; Brandão,C.E.; Mattos,A.A.; Lira,L.G.C.; Zamin Jr.,I.; Pinheiro,J.O.P.; Tovo,C.V.; Both,C.T.; Soares,J.A.S.; Dittrich,S.
Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Chronic hepatitis C; Genotype; Body weight; Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500003

Dengue: a review of the laboratory tests a clinician must know to achieve a correct diagnosis
Provedor de dados: 55
Autores: De Paula,Sérgio Oliveira; Fonseca,Benedito Antônio Lopes da.
Dengue is the most important disease caused by an arbovirus (1, 2, 3 and 4 serotypes) worldwide, especially in the tropical and sub-tropical regions. Its clinical manifestations range from asymptomatic infections to a severe disease characterized by hemorrhage and shock. The incidence of dengue virus activity in the Americas has substantially increased from 1980 to 1994. In Brazil, the increase in the incidence of dengue is especially linked to the dissemination of Aedes aegypti. Thus, a rapid and accurate dengue diagnosis is of paramount importance for effective control of dengue outbreaks [8]. Five serological tests have been used for the diagnosis of dengue infection: hemagglutination-inhibition (HI), complement fixation (CF), neutralization test (NT),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Diagnosis; Serology; PCR.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600002

Dengue and laboratory tests a clinician should know for a correct diagnosis
Provedor de dados: 55
Autores: Arya,Subhash C.; Agarwal,Nirmala.
Tipo: Info:eu-repo/semantics/other
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600001

Dengue hemorrhagic fever and acute hepatitis: a case report
Provedor de dados: 55
Autores: Mourão,Maria Paula Gomes; Lacerda,Marcus Vinícius Guimarães de; Bastos,Michele de Souza; Albuquerque,Bernardino Cláudio de; Alecrim,Wilson Duarte.
Dengue fever is the world's most important viral hemorrhagic fever disease, the most geographically wide-spread of the arthropod-born viruses, and it causes a wide clinical spectrum of disease. We report a case of dengue hemorrhagic fever complicated by acute hepatitis. The initial picture of classical dengue fever was followed by painful liver enlargement, vomiting, hematemesis, epistaxis and diarrhea. Severe liver injury was detected by laboratory investigation, according to a syndromic surveillance protocol, expressed in a self-limiting pattern and the patient had a complete recovery. The serological tests for hepatitis and yellow fever viruses were negative. MAC-ELISA for dengue was positive.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue; Dengue hemorrhagic fever; Hepatitis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600011

Dengue hemorrhagic fever complicated by pancreatitis
Provedor de dados: 55
Autores: Fontal,Guido Ricardo Gonzalez; Henao-Martinez,Andres Felipe.
Acute pancreatitis is an atypical complication of dengue fever and is rarely described. We are reporting a case of dengue hemorrhagic fever complicated by acute pancreatitis in a patient with history of diabetes mellitus type 1 and end stage renal disease on hemodialysis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue hemorrhagic fever; Pancreatitis; Diabetes mellitus type 1.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500015

Description of a widespread outbreak of aseptic meningitis due to echovirus 30 in Rio de Janeiro state, Brazil
Provedor de dados: 55
Autores: Pinto Junior,Vitor Laerte; Rebelo,Maria Cristina; Costa,Eliane Veiga da; Silva,Edson Elias da; Bóia,Márcio Neves.
Echovirus 30 belongs to the genus Enterovirus and is widely associated with aseptic meningitis (AM) outbreaks. In Brazil epidemics due to this serotype were reported in several states but in Rio de Janeiro, before this study, it was only involved in sporadic episodes. We retrospectively collected data from AM notifications charts and enterovirus isolation database from Rio de Janeiro State Health Department (RJSHD) and Enterovirus Reference Laboratory in the year of 2005. An outbreak of AM was detected during March, April and May associated with a high cell culture isolation rate for echovirus 30 (17.4%). Male children with ages varying from 1 to 9 years were more affected. Of the 22 patients with confirmed echovirus 30 disease, clinical information was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aseptic meningitis; Enterovirus; Echoviruses; Cerebrospinal fluid.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500011

Description of an HIV-1 BC recombinant virus identified in a pediatric patient in the city of São Paulo
Provedor de dados: 55
Autores: Souza,Ana Carolina Mamana Fernandes de; Oliveira,Cristina Mendes de; Marques,Heloisa H.S.; Levi,José Eduardo.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100014

Design and evaluation of an AFLP molecular marker for the detection of Coccidioides spp. in biological samples
Provedor de dados: 55
Autores: Reyes-Montes,María del Rocío; Frías-De-León,María Guadalupe; Victoriano-Pastelín,Isai; Acosta-Altamirano,Gustavo; Duarte-Escalante,Esperanza.
ABSTRACT At present, there is no standardized marker that is routinely used in clinical laboratories to diagnose coccidioidomycosis. Thus, the goals of this study were to obtain a sequence characterized amplified region (SCAR) marker for the identification of Coccidioides spp., evaluate its specificity and sensitivity in fungal DNA-spiked blood and sputum samples, and compare it with previously described molecular markers. Specific amplified fragment length polymorphism (AFLP) amplicons for Coccidioides immitis and Coccidioides posadasii were cloned into the vector pGEM® -T Easy vector and sequenced to develop a SCAR marker. Oligonucleotides were designed to identify Coccidioides spp. by polymerase chain reaction (PCR), and the specificity and sensitivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular markers; SCAR; Coccidioidomycosis; Coccidioides spp.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500322

Desmodus rotundus and Artibeus spp. bats might present distinct rabies virus lineages
Provedor de dados: 55
Autores: Fahl,Willian Oliveira; Carnieli Jr,Pedro; Castilho,Juliana Galera; Carrieri,Maria Luiza; Kotait,Ivanete; Iamamoto,Keila; Oliveira,Rafael Novaes; Brandão,Paulo Eduardo.
In Brazil, bats have been assigned an increasing importance in public health as they are important rabies reservoirs. Phylogenetic studies have shown that rabies virus (RABV) strains from frugivorous bats Artibeus spp. are closely associated to those from the vampire bat Desmodus rotundus, but little is known about the molecular diversity of RABV in Artibeus spp. The N and G genes of RABV isolated from Artibeus spp. and cattle infected by D. rotundus were sequenced, and phylogenetic trees were constructed. The N gene nucleotides tree showed three clusters: one for D. rotundus and two for Artibeus spp. Regarding putative N amino acid-trees, two clusters were formed, one for D. rotundus and another for Artibeus spp. RABV G gene phylogeny supported the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies Bat Artibeus spp.; Desmodus rotundus; Phylogeny; Molecular epidemiology.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600008

Detection and characterization of human rotavirus in hospitalized patients in the cities of Ponta Grossa, Londrina and Assai - PR, Brazil
Provedor de dados: 55
Autores: Nozawa,Carlos M; Kerntopf,Gustavo Franthesco; Czernisz,Érika da Silva; Albuquerque,Daniele; Romanin,Priscila; Freitas,José Felipe Eliseu; Santos,Norma; Benati,Fabrício José; Pietruchinski,Eduardo; Linhares,Rosa Elisa Carvalho.
Acute diarrheal disease is still one of the major public health problems worldwide. Rotaviruses (RV) are the most important viral etiologic agents and children under five years of age are the target population. OBJECTIVE: To investigate the rate of RV infection in hospitalized patients due to acute diarrhea in the cities of Ponta Grossa, Londrina and Assai - Paraná. METHODS: Latex agglutination (LA); immunochromatography (ICG); polyacrylamide gel electrophoresis (PAGE) and negative staining electron microscopy (ME) tests were used to detect the virus. For the genotyping, RT-PCR and RT-PCR-ELISA were used, respectively, for NSP4 and VP4/VP7. RESULT: Out of 124 samples there were 69 positive stool samples for RV, for at least one of the used tests, 67 of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; Determination; Hospitalized patients; Genotyping.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600002

Detection and molecular characterization of β-lactamase genes in clinical isolates of Gram-negative bacteria in Southern Ecuador
Provedor de dados: 55
Autores: Delgado,Diana Yessenia Calva; Barrigas,Zorayda Patricia Toledo; Astutillo,Sofía Genoveva Ochoa; Jaramillo,Ana Paulina Arévalo; Ausili,Alessio.
ABSTRACT This work performed a phenotypic and genotypic characterization of 79 clinical isolates of Enterobacteriaceae and Pseudomonadaceae collected in hospitals of Southern Ecuadorin 2013. Our results showed a high incidence of β-lactamases and ESBLs with blaTEM and blaCTX-M as the prevalent genes, respectively. By direct sequencing of PCR amplicons, the different β-lactamases and variants of the genes were also distinguished. Our results revealed a predominance of TEM-1 β-lactamase and the presence of different CTX-M variants with a prevalence of CTX-M-15. Two infrequent CTX-M variants in South America were also identified. To the best of our knowledge, this is one of the first studies describing the genetic characteristics of β-lactamases in Ecuador.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Β-Lactam resistance; Β-Lactamase; ESBL; Genotypic characterization.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600627

Detection of blaOXA-23 in Acinetobacter spp. isolated from patients of a university hospital
Provedor de dados: 55
Autores: Corrêa,Laís Lisboa; Botelho,Larissa Alvarenga Batista; Barbosa,Lívia Carvalho; Mattos,Claudio Simões; Carballido,Jupira Miron; Castro,Carmem Lúcia Teixeira de; Mondino,Pedro Juan Jose; Paula,Geraldo Renato de; Mondino,Silvia Susana Bona de; Mendonça-Souza,Claudia Rezende Vieira de.
INTRODUCTION: Acinetobacter spp. have emerged as notorious pathogens involved in healthcareassociated infections. Carbapenems are important antimicrobial agents for treating infections due to multidrug resistant Acinetobacter spp. Different mechanisms may confer resistance to these drugs in the genus, particularly production of class D carbapenemases. OXA-23-like family has been pointed out as one of the predominant carbapenamases among Acinetobacter. The present work aimed to investigate the occurrence of OXA-23-like carbapenemases among Acinetobacter isolates recovered from patients of a university hospital in Niterói, RJ, Brazil. METHODS: Antimicrobial susceptibility profiles were determined by disk-diffusion. Imipenem resistant isolates were submitted...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter spp; OXA-23; Carbapenem resistance.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600004

Detection of Chlamydia trachomatis in endocervical smears of sexually active women in Manaus-AM, Brazil, by PCR
Provedor de dados: 55
Autores: Santos,Cristina; Teixeira,Fabiane; Vicente,Ana; Astolfi-Filho,Spartaco.
Chlamydia trachomatis is now one of the most prevalent bacteria found in classic sexually transmissible diseases (STD), and as such, constitutes a serious public health problem. We examined the prevalence of Chlamydia trachomatis, by polymerase chain reaction (PCR), in 121 sexually active women who sought treatment for STD in the Alfredo da Matta Institute of Dermatology and Venerology and the Institute of Tropical Medicine of Amazonas in Manaus, Brazil. These women were examined by a specific PCR for the chlamydial plasmid, and the nature of the amplicon was determined by restriction analysis and DNA sequencing. The PCR diagnosis revealed a prevalence of 20.7% infected women.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; PCR; DST.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200001

Detection of E. coli O157:H7 and Shigella dysenteriae toxins in clinical samples by PCR-ELISA
Provedor de dados: 55
Autores: Amani,Jafar; Ahmadpour,Askary; Fooladi,Abbas Ali Imani; Nazarian,Shahram.
Shiga toxin producing bacteria are potential causes of serious human disease such as hemorrhagic colitis, severe inflammations of ileocolonic regions of gastrointestinal tract, thrombocytopenia, septicemia, malignant disorders in urinary ducts, hemolytic uremic syndrome (HUS) Shiga toxin 1 (stx1), shiga toxin 2 (stx2), or a combination of both are responsible for most clinical symptoms of these diseases. A lot of methods have been developed so far to detect shiga toxins such as cell culture, ELISA, and RFPLA, but due to high costs and labor time in addition to low sensitivity, they have not received much attention. In this study, PCR-ELISA method was used to detect genes encoding shiga toxins 1 and 2 (stx1 and stx2). To detect stx1 and stx2 genes, two...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Shigella dysenteriae; E.coliO157:H7; PCR-ELISA Diagnostic methods.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300278

Detection of GB virus C/hepatitis G markers in Chinese voluntary blood donors
Provedor de dados: 55
Autores: Xiao,Wei; Lin,Fangzhao; Sun,Pan; Ma,Li; Li,Changqing.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300352

Detection of genomic mutations in katG, inhA and rpoB genes of Mycobacterium tuberculosis isolates using polymerase chain reaction and multiplex allele-specific polymerase chain reaction
Provedor de dados: 55
Autores: Khosravi,Azar Dokht; Goodarzi,Hamed; Alavi,Seyed Mohammad.
OBJECTIVE: Isoniazid (INH) and rifampin (RIF) are the most effective first line antibiotics against Mycobacterium tuberculosis. Mutations in several genes determine resistance of M. tuberculosis to INH, with the most common gene target of katG, and resistance to RIF is due to mutation in rpoB gene. The aim of present study was to assess the mutations in the regions related to RIF and INH resistance. METHODS: We characterized 80 clinical isolates of confirmed M. tuberculosis to analyze the most commonly observed INH and RIF mutations. PCR analysis and sequencing were used to detect mutations related to RIF and INH resistance. The multiplex allele-specific-PCR (MAS-PCR) was performed as a comparative assay and for evaluation of this method. RESULTS: The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drug resistance Genes; MDR Mutation Polymerase chain reaction.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100010

Detection of group A beta-hemolytic Streptococcus employing three different detection methods: culture, rapid antigen detecting test, and molecular assay
Provedor de dados: 55
Autores: Santos,Odimara; Weckx,Luc Louis Maurice; Pignatari,Antonio Carlos Campos; Pignatari,Shirley Shizue Nagata.
In order to study the prevalence of Group A beta-hemolytic Streptococcus (GABHS) pharyngotonsillitis in our pediatric population and to compare different sampling methods of GABHS detection, oropharyngeal swabs from 50 children with acute pharyngotonsillitis, between 1 and 12 years old, were used simultaneously for culture, molecular assay and rapid GABHS antigen detection tests. All children were clinically examined at the Division of Pediatric Otorhinolaryngology of the Federal University of São Paulo. Diagnostic criteria were based on signs and symptoms, including sore throat, fever and oropharyngeal purulent secretion. Children that had been treated with antibiotics were excluded. Overall, combining the three methods, the prevalence of GABHS was 34%....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute pharyngotonsillitis; GABHS; Laboratory detection.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500003

Detection of HCV by PCR in serum and PBMC of patients with hepatitis C after treatment
Provedor de dados: 55
Autores: Cavalheiro,Norma de Paula; Filgueiras,Thelma Cristina; Melo,Carlos Eduardo; Morimitsu,Suzana Rie; Araújo,Evaldo Stanislau Affonso de; Tengan,Fátima Mitiko; Barone,Antonio Alci.
Although hepatitis C is mainly hepatotropic, some studies suggest that hepatitis C virus (HCV) infects peripheral blood mononuclear cells (PBMC), using them as a reservoir, which might contribute to the development of resistance to treatment. Fifty-four hepatitis-C patients, who had been submitted to treatment, were selected. Blood samples were collected on the same day for the detection of HCV RNA in serum and PBMC by PCR, using the Amplicor HCV 2.0 assay (Roche Diagnostics). HCV genotyping was performed using the INNO-LiPA HCV kit (Versant, Bayer Diagnostics). HCV RNA was detected in both serum and PBMC in 35 (64%) patients and no RNA in 16 (29.6%). Disagreement between the serum and PBMC results was observed for three patients (5.6%), with HCV RNA being...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: PCR; Hepatitis C; PBMC; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500006

Detection of hepatitis B virus A1762T/G1764A mutant by amplification refractory mutation system
Provedor de dados: 55
Autores: Wang,Yong-Zhong; Zhu,Zhen; Zhang,Hong-Yu; Zhu,Min-Zhi; Xu,Xin; Chen,Chun-Hua; Liu,Long-Gen.
OBJECTIVE: To study the role of hepatitis B virus with A1762T/G1764A double mutation in liver cirrhosis and hepatocellular carcinoma, and create a sensitive, fast, accurate assay for detection of A1762T/G1764A double mutation.METHODS: We developed an accurate and fast real-time amplification refractory mutation system to detect A1762T/G1764A double mutation. Cloned hepatitis B virus genome was used as a control. Assay sensitivity was determined by serial dilution and mixed template experiments. Specificity was determined by cross experiments with wild and mutant hepatitis B virus. Fifty clinical samples were tested by the real-time amplification refractory mutation system and the results were compared with sequencing.RESULTS: The real-time amplification...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Basal core promoter mutations; Amplification refractory mutation system; PCR.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300261

Detection of hepatitis C virus RNA in saliva samples from patients with seric anti-HCV antibodies
Provedor de dados: 55
Autores: Gonçalves,Patrícia L.; Cunha,Carla B.; Busek,Solange C. U.; Oliveira,Guilherme C.; Ribeiro-Rodrigues,Rodrigo; Pereira,Fausto EL.
We examined the frequency of HCV-RNA in saliva samples from anti-HCV positive patients. Both plasma and saliva samples from 39 HCV patients (13 with normal liver enzymes, 19 with abnormal liver enzymes and 13 with cirrhosis) were investigated. Stimulated saliva and fresh plasma were centrifuged (900 x g,10 min) and stored at -70ºC, after the addition of guanidine isothiocyanate RNA extraction buffer. HCV-RNA was detected by RT- nested-PCR (amplification of HCV-cDNA for two rounds, using HCV primers 939/209 and 940/211). HCV genotyping was carried out by RFLP (using Mva I and Hinf 1 or Hae III and Rsa I restriction enzymes). Thirty-two out of 39 (82%; 95% CI=70-94%) anti-HCV-positive patients had HCV-RNA in plasma samples. Eight out of 39 (20.5%; 95%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV-RNA in saliva; Hepatitis C; Saliva.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100006

Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay
Provedor de dados: 55
Autores: Torres,Laura Mendoza; Páez,Malvina; Insaurralde,Ariel; Rodriguez,María Isabel; Castro,Amalia; Kasamatsu,Elena.
Cervical cancer is the most frequent malignant tumour of women in Latin America being human papillomavirus (HPV) the main cause. The aim of this study was to increase the knowledge about the cervical infections with oncogenic HPV types (HR-HPV) in Asuncion, Paraguay. Two hundred and seventy-two cervical samples were analyzed using hybrid capture II assay (HCA II) for HR-HPV. The frequency of HR-HPV in the study group was 44%. HR-HPV was detected in 25% of the women negative for squamous intraepithelial lesions (NSIL), 72% with atypical squamous cells of undetermined significance (ASCUS), 68% with low SIL and 78% with high SIL. A moderate concordance was observed between HCA II assay and cytology (kappa: 0.43 IC95% 0.3 - 0.5). It was detected a high...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: High risk human papillomavirus; Hybrid capture II assay; Cytology.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300009

Detection of human papilloma virus in the tonsils of children undergoing tonsillectomy
Provedor de dados: 55
Autores: Ribeiro,Kátia Moreira Xavier; Alvez,Janaína Maria; Pignatari,Shirley S.N.; Weckx,Luc Louis Maurice.
Human papilloma virus (HPV) is related to respiratory mucosal diseases, such as recurrent respiratory papillomatosis, as well as to upper-respiratory-tract malignancies. There are few reports concerning the prevalence of HPV in the upper respiratory tract of non-affected individuals. We examined the prevalence of HPV in the tonsils of children of the general population scheduled for tonsillectomy. Samples were taken from the tonsils of 100 children undergoing tonsillectomy and were then tested for HPV with the polymerase chain reaction (PCR) technique, utilizing the generic primers MY09 and MY 11. The study excluded children known to have HPV and HIV-related diseases. Parents and legal guardians completed a standardized socio-demographic questionnaire. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Tonsils; Children.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300002

Detection of human papillomavirus DNA by the hybrid capture assay
Provedor de dados: 55
Autores: Carvalho,Maria Odete O.; Almeida,Ricardo W.; Leite,Fátima M. S.; Fellows,Ilza B.; Teixeira,Mariza H.; Oliveira,Ledy H. S.; Cavalcanti,Silvia M. B.
Human Papillomavirus (HPV) infection is the main cause of cervical cancers and cervical intraepithelial neoplasias (CIN) worldwide. Consequently, it would be useful to evaluate HPV testing to screen for cervical cancer. Recently developed, the second-generation Hybrid Capture (HCA II) test is a non-radioactive, relatively rapid, liquid hybridization assay designed to detect 18 HPV types, divided into high and low-risk groups. We evaluated 1055 women for HPV infection with the HCA II test. Five hundred and ten (48.3%) of these women had HPV infection; 60 (11.8%) had low cancer-risk HPV DNA; 269 (52.7%) had high-risk HPV types and 181 (35.5%) had both groups. Hence, 450 women (88.2%) in this HPV-infected group had at least one high risk HPV type, and were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; SIL; Cancer; Hybrid capture.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200004

Detection of methicillin resistance in Staphylococcus aureus isolated from pediatric patients: is the cefoxitin disk diffusion test accurate enough?
Provedor de dados: 55
Autores: Mimica,M.J.; Berezin,E.N.; Carvalho,R.L.B.; Mimica,I.M.; Mimica,L.M.J.; Sáfadi,M.A.P.; Schneider,E.; Caiaffa-Filho,H.H.
We evaluated the performance of several methods for the detection of methicillin resistance in Staphylococcus aureus using 101 clinical S. aureus isolates from pediatric patients in a tertiary hospital in Brazil; 50 isolates were mecA-positive and 51 were mecA-negative. The Etest and oxacillin agar screening plates were 100% sensitive and specific for mecA presence. Oxacillin and cefoxitin disks gave sensitivities of 96 and 92%, respectively, and 98% specificity. Alterations of CLSI cefoxitin breakpoints increased sensitivity to 98%, without decreasing specificity. Our results highlight the importance of a continuing evaluation of the recommended microbiological methods by different laboratories and in different settings. If necessary, laboratories should...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Disc diffusion; Cefoxitin; MecA.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400009

Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes
Provedor de dados: 55
Autores: Café Oliveira,Luita Nice; Muniz-Sobrinho,Jairo da Silva; Viana-Magno,Luiz Alexandre; Oliveira Melo,Sônia Cristina; Macho,Antonio; Rios-Santos,Fabrício.
Abstract Multidrug-resistant tuberculosis (MDRTB) is a serious world health problem that limits public actions to control tuberculosis, because the most used anti-tuberculosis first-line drugs fail to stop mycobacterium spread. Consequently, a quick detection through molecular diagnosis is essential to reduce morbidity and medical costs. Despite the availability of several molecular-based commercial-kits to diagnose multidrug-resistant tuberculosis, their diagnostic value might diverge worldwide since Mycobacterium tuberculosis genetic variability differs according to geographic location. Here, we studied the predictive value of four common mycobacterial mutations in strains isolated from endemic areas of Brazil. Mutations were found at the frequency of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biomarkers; Diagnosis; Multidrug-resistance; Mycobacterium tuberculosis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200166

Detection of mycobacteria in the bloodstream of patients with Acquired Immunodeficiency Syndrome in a University Hospital in Brazil
Provedor de dados: 55
Autores: Oplustil,Carmen Paz; Leite,Olavo H.M.; Oliveira,Marilia S.; Sinto,Sumiko I.; Uip,David E.; Boulos,Marcos; Mendes,Caio F.
This study was done to determine the occurrence of mycobacteria in the bloodstreams of patients with fever and advanced AIDS in a Brazilian hospital. We also verified the capability of an automated method for recovering these bacteria. During a period of 19 months, 254 patients with AIDS were evaluated. Blood cultures were generally submitted in pairs and drawn separately. Blood cultures were processed by the BACTEC 460TB System (Becton Dickinson Microbiology Systems, Sparks, MD), using the Bactec 13A media (Becton Dickinson Microbiology Systems, Sparks, MD). Of the 530 vials submitted, 77 (14.5%) from 41 (16%) patients were positive. Mycobacterium avium complex was recovered from 45 (58.4%) of the 77 positive vials, corresponding to 22 (53.6%) patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterial infection; HIV; Automated diagnosis; AIDS.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500003

Detection of SPM and IMP metallo-β-lactamases in clinical specimens of Pseudomonas aeruginosa from a Brazilian public tertiary hospital
Provedor de dados: 55
Autores: Camargo,Carlos Henrique; Bruder-Nascimento,Ariane; Mondelli,Alessandro Lia; Montelli,Augusto Cezar; Sadatsune,Terue.
Phenotypic and genotypic SPM and IMP metallo-β-lactamases (MBL) detection and also the determination of minimal inhibitory concentrations (MIC) to imipenem, meropenem and ceftazidime were evaluated in 47 multidrug-resistant Pseudomonas aeruginosa isolates from clinical specimens. Polymerase chain reaction detected 14 positive samples to either blaSPM or blaIMP genes, while the best phenotypic assay (ceftazidime substrate and mercaptopropionic acid inhibitor) detected 13 of these samples. Imipenem, meropenem and ceftazidime MICs were higher for MBL positive compared to MBL negative isolates. We describe here the SPM and IMP MBL findings in clinical specimens of P. aeruginosa from the University Hospital of Botucatu Medical School, São Paulo, Brazil, that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa drug resistance; Bacterial carbapenems metalloproteins poly merase chain reaction.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500011

Detection of the mecA gene and identification of Staphylococcus directly from blood culture bottles by multiplex polymerase chain reaction
Provedor de dados: 55
Autores: Rocchetti,Taisa Trevizani; Martins,Katheryne Benini; Martins,Patricia Yoshida Faccioli; Oliveira,Rogério Antonio de; Mondelli,Alessandro Lia; Fortaleza,Carlos Magno Castelo Branco; Cunha,Maria de Lourdes Ribeiro de Souza da.
ABSTRACT  Introduction: Staphylococcus spp. – both S. aureus, including methicillin-resistant strains (MRSA) and coagulase negative staphylococci (CoNS) – are relevant agents of healthcare-associated infections. Therefore, the rapid recognition of MRSA and methicillin-resistant CoNS from blood stream infections is critically important for patient management. It is worth noting that inappropriate empiric therapy has been associated with higher in-hospital mortality.  Material and methods: In this study we evaluated a multiplex polymerase chain reaction (multiplex PCR) standardized to detect Staphylococcus spp., S. aureus, and mecA gene-encoded oxacillin resistance directly from blood culture bottles. A total of 371 blood cultures with Gram-positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus spp.; Staphylococcus aureus; MRSA; MecA gene; Blood cultures; Multiplex PCR.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200099

Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460
Provedor de dados: 55
Autores: Jhamb,Sarbjit Singh; Goyal,Amit; Singh,Prati Pal.
BACTEC 460 has now been phased out, so the search for an alternative is imperative. We have determined the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro, by using BACTEC 460 and MGIT 960 methods. The minimum inhibitory concentrations of isoniazid, rifampicin, ethambutol and streptomycin against intracellular M. tuberculosis H37Rv were found to be 0.2, 0.8, 8.0, and 5.0 µg/mL, respectively, by both methods. These results show a significant (p &lt; 0.001) concordance between minimum inhibitory concentrations obtained by these two different methods. MGIT 960 system uses a robust florescence quenching-based oxygen sensor, requires no radioisotope, is safe, and relatively easy to operate. Apparently,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: BACTEC 460; Macrophages; MGIT 960; Mycobacterium tuberculosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300336

Determination of urine tumor necrosis factor, IL-6, IL-8, and serum IL-6 in patients with hemorrhagic fever with renal syndrome
Provedor de dados: 55
Autores: Fan,Wanhu; Liu,Xiaojing; Yue,Jinsheng.
OBJECTIVE: The aim of this study was to explore the role of cytokines in the pathogenesis of hemorrhagic fever with renal syndrome (HFRS). METHODS: Double-antibody sandwich ELISA was used to determine serum interleukin (IL)-6, urine tumor necrosis factor (TNF), IL-6, and IL-8 levels in 56 patients with HFRS. RESULTS: Serum IL-6, urine TNF, IL-6, and IL-8 concentrations in HFRS patients were significantly higher than those in the control group (p &lt; 0.001). the concentrations increased at fever stage, then continued to increase during the hypotension stage and peaked at the oliguria stage. the concentrations of serum IL-6, urine TNF, IL-6, and IL-8 increased according to the severity of the disease, and differed greatly among different types of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemorrhagic fever with renal; Syndrome; Interleukins; Tumor necrosis factor.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600005

Development and validation of a simple and rapid way to generate low volume of plasma to be used in point-of-care HIV virus load technologies
Provedor de dados: 55
Autores: Vasconcellos,Isabelle; Mariani,Diana; Azevedo,Marcelo C.V.M. de; Ferreira Jr.,Orlando C.; Tanuri,Amilcar.
ABSTRACT A new point-of-care HIV viral load, mPIMA HIV-1/2 VL, Abbott, USA, has been recently developed. This point-of-care viral load requires no skilled person to run and uses a small plasma volume (50 µL). However, obtaining 50 µL of plasma can be a challenge in limited resource settings. We validated a simple and easy method to obtain enough amount of plasma to run a point-of-care viral load. The study utilized 149 specimens from patients failing antiretroviral therapy. At least 250 µL of whole blood was collected in a microtube/EDTA from fingerstick (fs-plasma) and immediately centrifuged. Parallel collection of venous blood to obtain plasma (vp-plasma) was used to compare performance in a point-of-care viral load assay and in methodology used in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: POC VL; HIV viral load; HIV; Point-of-care; Fingerstick-plasma; MPIMA.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100030

Development of a clinical scoring system for the diagnosis of smear-negative pulmonary tuberculosis
Provedor de dados: 55
Autores: Soto,Alonso; Solari,Lely; Agapito,Juan; Acuna-Villaorduna,Carlos; Lambert,Marie-Laurence; Gotuzzo,Eduardo; Stuyft,Patrick Van der.
This study developed a clinical score based on clinical and radiographic data for the diagnosis of smear-negative pulmonary tuberculosis (SNPT). SNPT was defined as a positive culture in Ogawa in a patient with two negative sputum smears. Data from patients admitted to the emergency ward with respiratory symptoms and negative acid-fast bacilli (AFB) smears was analyzed by means of logistic regression to develop the predictive score.Two hundred and sixty two patients were included. Twenty patients had SNPT. The variables included in the final model were hemoptysis, weight loss, age &gt; 45 years old, productive cough, upper-lobe infiltrate, and miliary infiltrate. With those, a score was constructed. The score values ranged from -2 to 6. The area under the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Pulmonary; Regression analysis; Scoring methods.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200006

Development of a prototype immunochromatographic test for rapid diagnosis of respiratory adenovirus infection
Provedor de dados: 55
Autores: Paulini,Inarei; Siqueira-Silva,Joselma; Thomaz,Luciana; Rocha,Leticia; Harsi,Charlotte; Bellei,Nancy; Granato,Celso.
Abstract Human adenoviruses comprise an important group of etiologic agents that are responsible for various diseases in adults and children, such as respiratory, ocular, gastroenteric, and urinary infections. In immunocompromised and organ-transplanted individuals, these agents can cause generalized infections. Rapid diagnostic methods for detecting these infectious agents are not widely available.The aim of this work was to produce monoclonal and polyclonal anti-adenovirus antibodies to be used in a rapid diagnostic test for respiratory infections.Adenovirus hexons were satisfactorily purified by ultracentrifugation and chromatography. After virus purification, anti-hexon monoclonal antibodies were produced and characterized, following classical methods....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adenovirus; Monoclonal antibodies; Immunochromatographic test.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500500

Development of sandwich-form biosensor to detect Mycobacterium tuberculosis complex in clinical sputum specimens
Provedor de dados: 55
Autores: Shojaei,Taha Roodbar; Salleh,Mohamad Amran Mohd; Tabatabaei,Meisam; Ekrami,Alireza; Motallebi,Roya; Rahmani-Cherati,Tavoos; Hajalilou,Abdollah; Jorfi,Raheleh.
Mycobacterium tuberculosis, the causing agent of tuberculosis, comes second only after HIV on the list of infectious agents slaughtering many worldwide. Due to the limitations behind the conventional detection methods, it is therefore critical to develop new sensitive sensing systems capable of quick detection of the infectious agent. In the present study, the surface modified cadmium-telluride quantum dots and gold nanoparticles conjunct with two specific oligonucleotides against early secretory antigenic target 6 were used to develop a sandwich-form fluorescence resonance energy transfer-based biosensor to detect M. tuberculosis complex and differentiate M. tuberculosis and M. bovis Bacille Calmette–Guerin simultaneously. The sensitivity and specificity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis complex (MTBC); Cadmium-telluride quantum dots (CdTe-QDs); Gold nanoparticles (AuNPs); Fluorescence resonance energy transfer (FRET); Sandwich-form FRET-based biosensor.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600600

Diagnosis and quantitative detection of HSV DNA in samples from patients with suspected herpes simplex encephalitis
Provedor de dados: 55
Autores: Ziyaeyan,Mazyar; Alborzi,Abdolvahab; Haghighi,Afshin Borhani; Jamalidoust,Marziyeh; Moeini,Mahsa; Pourabbas,Bahman.
Diagnosis of herpes simplex encephalitis (HSE) is based on the detection of herpes simplex virus (HSV) DNA in patients' CSF samples. HSV DNA quantitation has the potential for estimating the effects of antiviral therapy. The aim of this study was to diagnose HSV DNA in HSE suspected patients and the quantitative analysis of its genome using real-time PCR to assess the value of the viral load in the course of antiviral treatment. The CSF samples were collected from 236 consecutive HSE suspected patients from November 2004 to May 2008. Upon DNA extraction, the samples were analyzed by Real-Time PCR assay. A set of primers amplified a common sequence of HSV glycoprotein B gene. The copy numbers of unknown samples were expressed via a standard curve drawn with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Encephalitis; Herpes simplex; Viral load; Acyclovir; Quantitative analysis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300005

Diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus in Latin America
Provedor de dados: 55
Autores: Zurita,Jeannete; Mejía,Carlos; Guzmán-Blanco,Manuel.
Strategies to monitor and control the spread of methicillin-resistant Staphylococcus aureus (MRSA) infections are dependent on accurate and timely diagnosis of MRSA in both hospital and community settings. In Latin America, significant diversity in diagnostic and susceptibility testing procedures exists at the regional, national and local levels. Various tests for S. aureus and MRSA are available in clinical settings, but the application of these techniques differs between and within countries, and quality control measures are not uniformly applied to verify diagnoses. To optimize the diagnosis of MRSA infections across Latin America, a more consistent approach is required. This may include: adoption and appropriate adaption of specific guidelines for MRSA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Diagnosis; Susceptibility testing; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800005

Diagnosis, antiretroviral therapy, and emergence of resistance to antiretroviral agents in HIV-2 infection: a review
Provedor de dados: 55
Autores: Hightower,Maia; Kallas,Esper Georges.
Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are the causative agents of AIDS. HIV-2 is prevalent at moderate to high rates in West African countries, such as Senegal, Guinea, Gambia, and Cape Verde. Diagnosis of HIV-2 is made with a positive HIV-1/HIV-2 ELISA or simple/rapid assay, followed by one or two confirmatory tests specific for HIV-2. Following CD4+ T cell counts, HIV-2 viral burden and clinical signs and symptoms of immunodeficiency are beneficial in monitoring HIV-2 disease progression. Although non-nucleoside reverse transcriptase inhibitors are ineffective in treating HIV-2, nucleoside reverse transcriptase inhibitors and protease inhibitors can be effective in dual and triple antiretroviral regimens. Their use can decrease...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-2; Antiretroviral treatment; Review.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100002

Diagnosis of American cutaneous leishmaniasis by enzyme immunoassay in patients from Northern Paraná State, Brazil
Provedor de dados: 55
Autores: Yoneyama,Kelly Aparecida Geraldo; Peder,Leyde Daiane de; Lonardoni,Maria Valdrinez Campana; Silveira,Thaís Gomes Verzignassi.
American cutaneous leishmaniasis (ACL) is an endemic disease caused by Leishmania parasites. The ACL diagnosis is commonly accomplished by parasitological and immunological methods. The objective of this work was to evaluate the enzyme immunoassay (EIA) for ACL laboratorial diagnosis. IgG antibodies against Leishmania (Viannia) braziliensis promastigotes were researched. For the method standardization 240 sera were used: 72 from patients with positive parasitological diagnosis, 38 from normal individuals and 113 from individuals with other pathologies. The sensibility was 93% and the specificity was 70%. Regarding diagnosis, EIA showed 97% positivity in patients with ACL and 97% negativity in patients with other cutaneous lesions. The EIA presented a good...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cutaneous leishmaniasis; Diagnosis; Antibodies; Immunoenzyme; Leishmania braziliensis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300012

Diagnosis of human papillomatosis by polymerase chain reaction in cases of divergence between results of hybrid capture and papanicolaou cytology
Provedor de dados: 55
Autores: Novaes,Luiz Carlos Garcez; Novaes,Maria Rita Carvalho Garbi; Simões-Barbosa,Augusto.
As various types of human papillomavirus (HPV) are involved in the pathogenesis of cervical cancer, correct diagnosis is of fundamental importance for screening programs. We evaluated the divergence of results between Papanicolaou cytology and hybrid capture by PCR detection of HPV DNA . A transversal study was conducted on 70 women attending private gynecological clinics in Brasilia, Brazil. PCRs were conducted with specific primers for general and high-risk HPV DNA. Based on the PCR results, hybrid capture was a superior diagnostic technique. When Papanicolaou was compared with the molecular biology methods, it was found that a positive Papanicolaou result does not necessarily indicate the presence of HPV. The agreement between PCR and hybrid capture...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Diagnosis; Hybrid capture; PCR.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300003

Diagnosis of human rabies cases by polymerase chain reaction of neck-skin samples
Provedor de dados: 55
Autores: Macedo,Carla Isabel; Carnieli Jr,Pedro; Brandão,Paulo Eduardo; Rosa,Elizabeth S. Travassos da; Oliveira,Rafael de Novaes; Castilho,Juliana Galera; Medeiros,Rita; Machado,Rosangela Rocha; Oliveira,Rosely Cerqueira de; Carrieri,Maria Luiza; Kotait,Ivanete.
Rapid diagnosis of rabies in suspected human cases influences post-exposure prophylaxis for potential contacts of the patient and ensures appropriate patient management. Apart from the central nervous system (CNS), rabies virus (RABV) is usually present in small sensory nerves adjacent to hair follicles of infected humans. We used an RT-PCR, with primers targeted to the 3' terminal portion of the nucleoprotein gene (N), to test neck-skin samples of nine patients who had rabies in order to validate a diagnostic method that could serve as an additional tool for rabies diagnosis, particularly in antemortem samples. Six of eight postmortem samples were found to be positive for rabies by RT-PCR, and one of two samples collected antemortem was positive with this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human rabies; Neck-skin; Diagnosis; RT-PCR; DNA sequencing.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500008

Diagnosis of pulmonary tuberculosis by score system in children and adolescents: a trial in a reference center in Bahia, Brazil
Provedor de dados: 55
Autores: Sant'Anna,Clemax Couto; Santos,Marilene Augusta R. C.; Franco,Rosana.
Since 2002, the Brazilian Ministry of Health has recommended a score system for tuberculosis diagnosis of children and adolescents that does not need bacteriological positivity, because most cases in this age group have few bacteria. An observational, transversal study was carried out at the outpatient health care service of the reference medical service in Salvador, Bahia, including 164 patients with pulmonary tuberculosis, with ages ranging between 1 and 15 years of age, who were treated from 1990 to 2001. The gold standard used to establish the diagnosis was clinical, radiological, epidemiological and based on follow-up data. The score system for diagnosis purposes was tested retrospectively. The median age and the average age of the 164 patients were 6...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary tuberculosis; Diagnosis; Child; Adolescents.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400006

Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS
Provedor de dados: 55
Autores: Pereira,Araiz Cajueiro Carneiro; Lacerda,Heloísa Ramos de; Barros,Romualda Castro do Rêgo.
Abnormalities found with anuscopy under colposcopic vision, anal cytology and anal biopsy were evaluated in 21 men with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at the Federal University of Pernambuco Hospital in Brazil. Mean age was 38.4 ± 6.0 years, and mean time of HIV infection was 8.3 ± 5.1 years; 95.2% of the patients had been on highly active antiretroviral therapy (HAART) for an average of 6.6 ± 4.5 years. Mean CD4+ cell count was 482.2 ± 173.75 cells/mm³, and 80.9% presented a HIV viral load of &lt; 5,000 copies/mL. Reported sexual preference was 52.4% homosexuals, 28.6% bisexuals, and 19.0%heterosexuals; 81% reported having had receptive anal intercourse and 61.9% reported more than 10 sexual partners of the same...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; HPV; Anuscopy; Anal cytology; Anal biopsy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400007

Diagnostic parameters and reliability of four rapid immunochromatographic tests for dengue 4
Provedor de dados: 55
Autores: Mata,Veronica Elizabeth; Passos,Sonia Regina Lambert; Santos,Maria Angelica Borges dos; Buonora,Sibelle Nogueira; de Andrade,Carlos Augusto Ferreira; Lima,Monique da Rocha Queiroz; Costa,Betina Moreira; Hökerberg,Yara Hahr Marques.
ABSTRACT  Background: Although performance of rapid immunochromatographic tests (RITs) for dengue virus (DENV) serotypes 1, 2 and 3 is relatively settled, evidence on accuracy of RITs for DENV-4 are based on studies with small sample sizes and with discrepant results.  Objectives: To assess accuracy and inter-observer agreement of RITs targeting dengue nonstructural protein-1 (NS1) antigen - Dengue NS1-Bioeasy™, Dengue NS1 Ag Strip-Bio-Rad™, IVB Dengue Ag NS1-Orangelife™ and Dengue NS1-K130-Bioclin™ in DENV-4 samples.  Methods: Study sample (n = 324) included adults presenting at an emergency unit in Rio de Janeiro, Brazil, with fever of ≤72 h and two or more dengue symptoms. A serum sample from each patient was tested by each RIT. A positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Immunochromatographic tests; Sensitivity and specificity; Reproducibility of tests; Diagnosis.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100058

Diagnostic-driven antifungal therapy in neutropenic patients using the D-index and serial serum galactomannan testing
Provedor de dados: 55
Autores: Garnica,Marcia; Sinhorelo,Aline; Madeira,Laura; Portugal,Rodrigo; Nucci,Marcio.
Abstract  Introduction Invasive mold disease is an important complication of patients with hematologic malignancies, and is associated with high mortality. A diagnostic-driven approach has been an alternative to the classical empiric antifungal therapy. In the present study we tested an algorithm that incorporated risk stratification using the D-index, serial serum galactomannan and computed tomographic-scan to guide the decision to start antifungal therapy in neutropenic patients.  Patients and methods Between May 2010 and August 2012, patients with acute leukemia in induction remission were prospectively monitored from day 1 of chemotherapy until discharge or death with the D-index and galactomannan. Patients were stratified in low, intermediate and high...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fungal disease; Leukemia; Risk stratification; Neutropenia.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400354

Differences in the replicative capacities of clinical isolates of dengue virus in C6/36 cells and in urban populations of Aedes aegypti from Colombia, South America
Provedor de dados: 55
Autores: Quintero-Gil,Diana Carolina; Uribe-Yepes,Alexander; Ospina,Marta; Díaz,Francisco Javier; Martinez-Gutierrez,Marlen.
ABSTRACT Dengue, the most prevalent arboviral disease worldwide, is caused by any of the four dengue virus (DENV) serotypes that co-circulate constantly in hyperendemic areas such as Medellin (Colombia), and these serotypes are transmitted by mosquitoes of the genus Aedes. In this study, we evaluated the replicative capacity of strains isolated in Medellin between 2003 and 2007 in C6/36 cells and in colonies of Aedes aegypti collected during 2010-2011 from high or low-incidence areas within the same city. The phylogenetic analysis grouped isolates according to the predominant genotypes found in the Americas, and the in vitro characterization showed differences in the morphological changes induced by the isolates of each of the isolated serotypes compared...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Viral replication; Vector competence; Aedes aegypti; C6/36 cells; Colombia.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400257

Differential expression on mitochondrial tryparedoxin peroxidase (mTcTXNPx) in Trypanosoma cruzi after ferrocenyl diamine hydrochlorides treatments
Provedor de dados: 55
Autores: Kohatsu,Andréa A.N.; Silva,Flávia A.J.; Francisco,Acácio I.; Rimoldi,Aline; Silva,Marco T.A.; Vargas,Maria D.; Rosa,João A. da; Cicarelli,Regina M.B.
Abstract Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed with ferrocenyl diamine hydrochlorides in six different strains of T. cruzi epimastigote forms (Y, Bolivia, SI1, SI8, QMII, and SIGR3). The last four strains have been recently isolated from triatominae and mammalian host (domestic cat). The expression of mitochondrial tryparedoxin peroxidase was analyzed by the Western blotting technique using polyclonal antibody anti mitochondrial tryparedoxin peroxidase obtained from a rabbit immunized with the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Ferrocenyl diamine hydrochlorides; Mitochondrial tryparedoxin peroxidase (mTcTXNPx); Oxidative stress mechanisms.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200125

Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells
Provedor de dados: 55
Autores: Shi,Weifeng; Hou,Xueling; Li,Xiang; Peng,Hongjun; Shi,Mei; Jiang,Qingbo; Liu,Xiping; Ji,Yun; Yao,Yuhua; He,Caizhen; Lei,Xiangdong.
BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in response to viral infection. The aim of this study was to explore the function and mechanism of MAPK signaling pathway in enterovirus 71 (EV71) infection of human rhabdomyosarcoma (RD) cells. METHODS: Apoptosis of RD cells was observed using annexin V-FITC/PI binding assay under a fluorescence microscope. Cellular RNA was extracted and transcribed to cDNA. The expressions of 56 genes of MAPK signaling pathway in EV71-infected RD cells at 8 h and 20 h after infection were analyzed by PCR array. The levels of IL-2, IL-4, IL-10, and TNF-α in the supernatant of RD cells infected with EV71 at different time points were measured by ELISA. RESULTS: The viability of RD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterovirus 71; Rhabdomyosarcoma cells; MAPK; PCR array.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400005

Differential replicative fitness of the four dengue virus serotypes circulating in Colombia in human liver Huh7 cells
Provedor de dados: 55
Autores: Gutiérrez-Barbosa,Hernando; Castañeda,Nadia Y.; Castellanos,Jaime E.
ABSTRACT Dengue has been a significant public health problem in Colombia since the simultaneous circulation of the four dengue virus serotypes. The replicative fitness of dengue is a biological feature important for virus evolution and contributes to elucidating the behavior of virus populations and viral pathogenesis. However, it has not yet been studied in Colombian isolates. This study aimed to compare the replicative fitness of the four dengue virus serotypes and understand the association between the serotypes, their in vitro infection ability, and their replication in target cells. We used three isolates of each DENV serotype to infect Huh-7 cells at an MOI of 0.5. The percentage of infected cells was evaluated by flow cytometry, cell viability was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue virus; Dengue serotypes; Replicative fitness; Dengue strains.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100013

Differentiation of wild-type varicella-zoster strains from India and the Oka vaccine strain using a VZV open reading frame - 62 based PCR-RFLP technique
Provedor de dados: 55
Autores: Kaushik,Karishma S.; Lahiri,Kunal K.; Kapila,Ketoki; Kumar,Satish; Gupta,Rajiv M.; Karade,Santosh.
Since the introduction of varicella vaccination in India, surveillance of circulating VZV strains has gained significance. Differentiating wild-type VZV strains from the Oka vaccine strain can be achieved only by molecular genotyping methods. The development of PCR methods for VZV strain differentiation has been hampered by the fact that the VZV genome is highly conserved. We used VZV ORF 62 PCR-RFLP analysis to identify and differentiate wild-type VZV strains in India from the Oka vaccine strain. Digestion of VZV ORF 62 amplicons with SmaI, enabled accurate strain differentiation; the Oka strain was positive for three SmaI sites, compared to two SmaI sites in the wild-type VZV strains that we tested.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Varicella-zoster virus; ORF 62; OKA strain.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400011

Difficulties with interferon treatment in former intravenous drug users
Provedor de dados: 55
Autores: Gazdag,Gábor; Horváth,Gergely; Szabó,Olga; Ungvari,Gabor S.
OBJECTIVES: Intravenous drug use accounts for most of the new hepatitis C infections worldwide. Although there is an urgent need for antiviral treatment of infected intravenous drug users (IDUs), several factors compromise their treatment including lack of treatment adherence and high dropout rate. The aim of this study was to compare antiviral treatment-related problems among former IDUs to HCV-infected patients without a history of IDU. METHODS: This was a retrospective chart review of HCV-infected IDUs who received combined antiviral therapy at the Hepatology Outpatient Clinic of Szent László Hospital between 1 January 2006 and 31 December 2008. A control group of interferon treated patients with no history of IDU matched for age and sex was selected....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Psychiatry; Hepatitis C; Substance-related disorders.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200013

Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review
Provedor de dados: 55
Autores: Zhao,Wenxue; Ji,Fanpu; Yu,Shanshan; Li,Zongfang; Deng,Hong.
Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pegylated interferon; Adverse drug reaction; Cardiotoxicity; Thyroid dysfunction.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100110

Direct detection of blaOXA-23 gene from endotracheal aspirates by real time PCR
Provedor de dados: 55
Autores: Brust,Flávia R.; Massi,Lisandra; Cantarelli,Vlademir V.; Zavascki,Alexandre P.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400018

Direct identification from positive blood broth culture by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)
Provedor de dados: 55
Autores: Barberino,Maria Goreth; Silva,Marcio de Oliveira; Arraes,Ana Carolina Palmeiras; Correia,Luís Cláudio; Mendes,Ana Verena.
ABSTRACT Bloodstream infections (BSIs) are among the most concerning bacterial infections. They are one of the leading causes of morbidity and mortality, and occur in 30-70% of critical care patients. The prompt identification of the causative microorganism can help choosing the appropriate antimicrobial therapy that will lead to better clinical outcomes. Blood culture is one of the most relevant tests for microbiological diagnosis of bacterial infections. The introduction of the MALDI-TOF microbiological diagnosis significantly decreased the time of identifying microorganisms. However, it depends on the growth on solid culture medium. In this study, 538 bottles of positive blood cultures were evaluated to test the accuracy of an in house modified...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: MALDI-TOF; Blood culture; Bacterial identification.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300339

Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry and real-time PCR in a combined protocol for diagnosis of bloodstream infections: a turnaround time approach
Provedor de dados: 55
Autores: Quiles,Milene Gonçalves; Boettger,Bruno Cruz; Inoue,Fernanda Matsiko; Monteiro,Jussimara; Santos,Daniel Wagner; Ponzio,Vinicius; Carlesse,Fabianne; Cappellano,Paola; Carvalhaes,Cecilia Godoy; Pignatari,Antonio Carlos Campos.
ABSTRACT Bloodstream infections (BSIs) are serious infections associated with high rates of morbidity and mortality. Every hour delay in initiation of an effective antibiotic increases mortality due to sepsis by 7%. Turnaround time (TAT) for conventional blood cultures takes 48 h, forcing physicians to streamline therapy by exposing patients to broad-spectrum antimicrobials. Our objective was (1) to evaluate the accuracy and TAT of an optimized workflow combining direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and in-house real-time polymerase chain reaction (PCR) for bacterial identification and antimicrobial resistance profiling directly from positive blood bottles for diagnosing bloodstream infections...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bloodstream infections; Molecular diagnosis; Molecular panels; PCR; Mass spectrometry.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300164

Disease burden of chronic hepatitis C in Brazil
Provedor de dados: 55
Autores: Ferreira,Paulo Roberto Abrão; Brandão-Mello,Carlos Eduardo; Estes,Chris; Gonçales Júnior,Fernando Lopes; Coelho,Henrique Sérgio Moraes; Razavi,Homie; Cheinquer,Hugo; Wolff,Fernando Herz; Ferraz,Maria Lúcia Gomes; Pessoa,Mário Guimarães; Mendes-Correa,Maria Cássia.
Background: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantiﬁed. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).Results: The number of infected...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Disease burden; Epidemiology; Incidence; Brazil.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363

Disseminated Bacille Calmette-Guérin disease in immunocompetent adult patients
Provedor de dados: 55
Autores: Nascimento,Luísa; Linhas,Ana; Duarte,Raquel.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400408

Disseminated cutaneous leishmaniasis: a patient with 749 lesions
Provedor de dados: 55
Autores: Sousa,Anastácio Q.; Pompeu,Margarida M.L.; Sólon,F.R.Neves; Frutuoso,Mércia S.; Teixeira,M. Jania; Silva,Terezinha M.J.
Tipo: Info:eu-repo/semantics/article
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300013

Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions
Provedor de dados: 55
Autores: Sgarbi,Isabela Martins; Santos,Flávia da Silva Domingos; Monteiro,Veridiana Elisa; Fonseca,Silvia Nunes Szente; Bernardes Filho,Fred.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200201

Disseminated cysticercosis with asymptomatic involvement of the heart
Provedor de dados: 55
Autores: Sousa,Anastácio de Queiroz; Solon,F. Roberto Neves; Costa Filho,J. Eloy da; Lima,F. Heli Cavalcante.
Tipo: Info:eu-repo/semantics/report
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100014

Disseminated fusariosis presenting with pulmonary nodules following a line infection
Provedor de dados: 55
Autores: Madariaga,Miguel G; Kohl,Shane.
Tipo: Info:eu-repo/semantics/other
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600014

Disseminated Fusarium infection in autologous stem cell transplant recipient
Provedor de dados: 55
Autores: Avelino-Silva,Vivian Iida; Ramos,Jessica Fernandes; Leal,Fabio Eudes; Testagrossa,Leonardo; Novis,Yana Sarkis.
Disseminated infection by Fusariumis a rare, frequently lethal condition in severely immunocompromised patients, including bone marrow transplant recipients. However, autologous bone marrow transplant recipients are not expected to be at high risk to develop fusariosis. We report a rare case of lethal disseminated Fusariuminfection in an autologous bone marrow transplant recipient during pre-engraftment phase.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Stem cell transplant; Autologous; Fusarium.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100090

Disseminated histoplasmosis in HIV positive patients in Espírito Santo state, Brazil: a clinical-laboratory study of 12 cases (1999-2001)
Provedor de dados: 55
Autores: Casotti,Janaina Aparecida Schineider; Motta,Tânia Queiroz Reuter; Ferreira Júnior,Carlos Urbano Gonçalves; Cerutti Junior,Crispim.
Twelve cases of histoplasmosis in HIV-infected patients were found in a retrospective analysis at the Hospital Universitário Cassiano Antônio de Moraes of the Universidade Federal do Espírito Santo (HUCAM), Vitória (ES), from June 1999 to May 2001. The frequency of histoplasmosis among HIV-positive patients was 2.1% in the infectious diseases division of the hospital during this period. Histoplasmosis compromised mainly males (11/12), 27 to 44 years old, and residents of the metropolitan urban area (10/12). Alcohol abuse and tobacco smoking were described in 10 of the 12 patients. For all patients, this was the first opportunistic infection. Two of the 12 patients died; 10 patients had disseminated disease, one patient had an intestinal presentation and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histoplasmosis; AIDS; Diagnosis; Case series.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500005

Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess
Provedor de dados: 55
Autores: Metta,Humberto; Corti,Marcelo; Brunzini,Ricardo.
Mycobacteria other than tuberculosis (MOTT) have a low incidence as pathogens in human pathology. The most frequent clinical expression is the disseminated disease in subjects with compromised cellular immunity. Bacteriological characteristics in culture can generate confusion with other pathogens, which delays the appropriate diagnosis and treatment. We present a case of a disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess in a man with a medical background of cellular immunity deficit induced by therapeutic drugs. The antibiotic scheme of twenty-one weeks, during the follow-up period, controlled the infection, however, the optimum duration of treatment has not been established.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: M. chelonae; Scleritis; Spondylodiscitis; Spinal epidural abscess.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300019

Disseminated tuberculosis and human immunodeficiency virus infection
Provedor de dados: 55
Autores: Zaki,Syed Ahmed.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500019

Disseminated tuberculosis presenting as mesenteric and cerebral abscess in HIV infection: case report
Provedor de dados: 55
Autores: Pandit,Vinay; Valsalan,Rohith; Seshadri,Shubha; Bahuleyan,Shibu.
Disseminated tuberculosis in HIV infection involves multiple organs. Pulmonary and lymph node involvement are the commonest form of tuberculosis in HIV infection [1, 2]. Other forms of tuberculosis in the absence of lung and lymph node involvement are rare. Various forms of abdominal [3, 4] and neurological [5, 6] tubercular involvement in HIV infection have been reported. But tuberculosis presenting simultaneously with mesenteric and brain abscess has not been reported yet. We report a case of disseminated tuberculosis presenting as mesenteric and cerebral abscess in a HIV case without involving lung and lymph nodes. Bone marrow smears and fine needle aspiration cytology (FNAC) from mesenteric lesion were positive for acid fast bacilli (AFB) and the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Tuberculosis; Abscess.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500014

Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates
Provedor de dados: 55
Autores: Coutinho,Vivian de Lima Spode; Paiva,Rodrigo Minuto; Reiter,Keli Cristine; de-Paris,Fernanda; Barth,Afonso Luis; Machado,Alice Beatriz Mombach Pinheiro.
INTRODUCTION: Resistance to macrolides, lincosamides and streptogramins B (MLS B antibiotics) in staphylococci may be due to modification in ribosomal target methylase encoded by erm genes. The expression of MLS B resistance lead to three phenotypes, namely constitutive resistance (cMLS B), inducible resistance (iMLS B), and resistance only to macrolides and streptogramins B (MS B). The iMLS B resistance is the most difficult to detect in the clinical laboratory. OBJECTIVE: This study investigated the expression of MLS B resistance and the prevalence of the erm genes among 152 clinical isolates of Staphylococcus aureus and coagulase-negative Staphylococcus (CNS) from Hospital de Clínicas de Porto Alegre. METHODS: Primary MLS B resistance was detected by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus; Resistance; Erm genes; Macrolides.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600004

Distribution of filamentous fungi causing invasive fungal disease at the haematological unit, Hospital de Clínicas de Porto Alegre, Brazil
Provedor de dados: 55
Autores: Aquino,Valério Rodrigues; Verçosa,Emanuelle Bergonsi; Falhauber,Gustavo; Lunardi,Luciano Werle; Silla,Lucia; Pasqualotto,Alessandro Comarú.
Very limited data are available in the literature to elucidate the aetiology of invasive mould infections in Latin America. Here we report that Aspergillus species caused only half of such cases in a cohort study conducted over 21 months in a university hospital in Porto Alegre, Southern Brazil. Fusarium spp. were the second most prevalent moulds (20.7%), followed by Zygomycetes (13.8%). The importance of obtaining local epidemiological data for adequately guiding empirical antifungal therapy is reinforced.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aspergillus; Fusarium; Mold infections; Epidemiology; Zygomycosis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300013

Distribution of HBV subgenotypes in Ribeirão Preto, Southeastern Brazil: a region with history of intense Italian immigration
Provedor de dados: 55
Autores: Chachá,Silvana Gama Florencio; Gomes-Gouvêa,Michele Soares; Malta,Fernanda de Mello; Ferreira,Sandro da Costa; Villanova,Márcia Guimarães; Souza,Fernanda Fernandes; Teixeira,Andreza Correa; Passos,Afonso Dinis da Costa; Pinho,João Renato Rebello; Martinelli,Ana de Lourdes Candolo.
Abstract Hepatitis B virus (HBV) is distributed worldwide, with geographical variations regarding prevalence of the different genotypes. The aim of this study was to determine the HBV genotypes and subgenotypes circulating in Southeast Brazil and compare the genetic sequences found with HBV sequences previously described in the world. Sequences from 166 chronic HBV carriers were analyzed using the fragment constituted by 1306 base pairs comprising surface and polymerase regions of the HBV genome. The sequences obtained were submitted to phylogenetic analysis. HBV subgenotypes A1, A2, D1-D4, F2a, and F4 were found. HBV genotype D was the most frequent, found in 99 patients (58.4%). Within this group, subgenotype D3 was the most prevalent, in 73 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Genotype; Phylogenetics; Intra-familial transmission.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400424

Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis
Provedor de dados: 55
Autores: Rodrigues,Denise do Socorro S.; Cunha,Rosangela M. de C.; Kallas,Esper Georges; Salomao,Reinaldo.
CD4+ and CD8+ T lymphocyte counts, naive and memory/effector CD4+ T subpopulations, and the expression of CD38 on CD8+ T lymphocytes were evaluated in four groups: AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20) and healthy controls (CTL, n=17). TB and HIV had fewer CD4+ T cells than CTL, with the lowest values observed in TB/HIV (p&lt;0.001). No difference between groups was observed in the percentage of naive and memory/effector subpopulations in CD4+ T lymphocytes. TB (355 cells/mL) and HIV (517 cells/mL) had diverging effects on CD8+ T cell counts, with a marked depletion observed in HIV/TB (196 cells/mL). TB and HIV up-regulated CD38 expression on CD8+ T cells, a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; AIDS; CD38; CD4+; CD8+ T lymphocytes.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200010

Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil
Provedor de dados: 55
Autores: Grimaldi,Rogerio; Acosta,AX; Machado,TMB; Bomfim,TF; Galvão-Castro,B.
A mutation described as a G-to-A transition has been reported in SDF-1 gene (SDF1-3'A), being prevalent in all ethnic groups, except in Africans. This mutation is associated with the onset of AIDS progression. Our aim was to identify the frequency of this allele in different groups from Brazil: Tiriyó and Waiampi Amerindian tribes (Asian ancestry); selected blood donors from Joinville (German descendents); and from Salvador (predominance of African and Portuguese mixture). SDF1-3'A was screened by PCR/RFLP with MspI enzyme. Our results showed a high allelic frequency in Tiriyó tribe (0.24) and Joinville population (0.21), and a frequency of 0.17 and 0.05 in the Salvador population and in the Waiampi tribe, respectively. There was no statistical difference...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: SDF1-3'A polymorphism; Brazilian population; HIV-1 co-receptor.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200017

Distribution of serotypes and evaluation of antimicrobial susceptibility among human and bovine Streptococcus agalactiae strains isolated in Brazil between 1980 and 2006
Provedor de dados: 55
Autores: Pinto,Tatiana Castro Abreu; Costa,Natália Silva; Souza,Aline Rosa Vianna; Silva,Ligia Guedes da; Corrêa,Ana Beatriz de Almeida; Fernandes,Flavio Gimenis; Oliveira,Ivi Cristina Menezes; Mattos,Marcos Corrêa de; Rosado,Alexandre Soares; Benchetrit,Leslie Claude.
Streptococcus agalactiae is a common agent of clinical and subclinical bovine mastitis and an important cause of human infections, mainly among pregnant women, neonates and nonpregnant adults with underlying diseases. The present study describes the genetic and phenotypic diversity among 392 S. agalactiae human and bovine strains isolated between 1980 and 2006 in Brazil. The most prevalent serotypes were Ia, II, III and V and all the strains were susceptible to penicillin, vancomycin and levofloxacin. Resistance to clindamycin, chloramphenicol, erythromycin, rifampicin and tetracycline was observed. Among the erythromycin resistant strains, mefA/E, ermA and, mainly, ermB gene were detected, and a shift of prevalence from the macrolide resistance phenotype...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus agalactiae; Pulsed field gel electrophoresis; Epidemiology; Serotyping; Resistance profile.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200003

Diversity of genotypes in CTX-M-producing Klebsiella pneumoniae isolated in different hospitals in Brazil
Provedor de dados: 55
Autores: Chagas,Thiago Pavoni Gomes; Alves,Ronaldo Mendes; Vallim,Deyse Christina; Seki,Liliane Miyuki; Campos,Leila Carvalho; Asensi,Marise Dutra.
OBJECTIVE: The present study was undertaken to characterize CTX-M ESBL-producing Klebsiella pneumoniae collected from hospitals in different cities of Brazil. MATERIAL AND METHODS: Eighty-five K. pneumoniae strains isolated from hospitalized patients in six different hospitals of three cities of Brazil were analyzed. ESBL production was confirmed by the standard double-disk synergy test and the Etest®. The MIC50 and MIC90 for ESBL-producing isolates were determined by the Etest® method. The antimicrobial susceptibilities of bacterial isolates were determined using the agar diffusion method according to the CLSI. Screening for blaTEM, blaSHV, blaCTX-M genes and class 1 integron was performed by PCR amplification. To determine the genomic diversity of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Klebsiella pneumoniae; Β-lactamases; Genotype.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500002

DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian region - Brazil
Provedor de dados: 55
Autores: Aleixo,Rodrigo Queiroz; Scherma,Alexandre Prado; Guimarães,Gustav; Cortelli,José Roberto; Cortelli,Sheila Cavalca.
We evaluated the DMFT (decayed, missing and filled teeth) index and the prevalence of candidiasis, linear gingival erythema, oral hairy leukoplakia, herpes simplex, aphthous ulcers, Kaposi's sarcoma and lymphoma, as well as the association with TCD4 count, viral load (VL) and antiretroviral therapy (ART) in 140 HIV-infected adult individuals. A standardized examination to determine the DMFT index and the presence of oral lesions was conducted. Demographic data, TCD4 count and use of ART were obtained from medical records. A high number of decayed teeth detected among patients undergoing ART resulted in a mean DMFT of 16.9 teeth. It was observed that 24.2% of the individuals had at least one oral lesion. Candidiasis was the most frequent lesion and was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oral mucosal lesions; DMFT index; Tooth decay; HIV infection.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500005

Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients?: A mini-review
Provedor de dados: 55
Autores: Song,Alice Tung Wan; Abdala,Edson; Bonazzi,Patrícia Rodrigues; Bacchella,Telésforo; Machado,Marcel Cerqueira César.
Mycophenolate mofetil (MMF) is currently used for prophylaxis of acute rejection in solid organ transplantation. There have been diverging reports regarding an association between MMF and the risk of cytomegalovirus (CMV) infection. We reviewed the main published studies in an attempt to clarify the association between the use of MMF and the risk, frequency and severity of CMV infections. In a search of the Medline database with the terms "mycophenolate" and "cytomegalovir*", 42 articles were found to be relevant; among these, 29 articles were thoroughly analyzed. The first studies on MMF in renal transplantation already showed a tendency towards an association between this drug and the occurrence of CMV disease. Further studies were designed specifically...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycophenolate mofetil; Cytomegalovirus; Transplant.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200011

Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study
Provedor de dados: 55
Autores: Rosa,Regis Goulart; Moraes,Rafael Barberena; Lisboa,Thiago Costa; Schunemann,Daniel Pretto; Teixeira,Cassiano.
ABSTRACT We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points). From January 2008 to December 2014, 1487 patients were admitted to the ICU due to suspected infection. SOFA ≥2...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sepsis; Intensive care unit; Organ dysfunction; Outcomes.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600665

Does the change on gastrointestinal tract microbiome affects host?
Provedor de dados: 55
Autores: Beirão,Elisa M.; Padovan,Ana Carolina B.; Furtado,Juvêncio J.D.; Colombo,Arnaldo L.; Medeiros,Eduardo A.S.
During the past decade, studies on the composition of human microbiota and its relation to the host became one of the most explored subjects of the medical literature. The development of high-throughput molecular technologies allowed a deeper characterization of human microbiota and a better understanding of its relationship with health and disease. Changes in human habits including wide use of antimicrobials can result in dysregulation of host–microbiome homeostasis, with multiple consequences. The purpose of this review is to highlight the most important evidence in the literature of host–microbiome interactions and illustrate how these intriguing relations may lead to new treatment and prevention strategies.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gastrintestinal microbiome; Human.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600660

Donovanosis
Provedor de dados: 55
Autores: Velho,Paulo Eduardo Neves Ferreira; Souza,Elemir Macedo de; Belda Junior,Walter.
Donovanosis is a chronic bacterial illness frequently associated with sexually transmitted infections (STI) and is under diagnosed both in endemic areas as well as in countries in which doctors have little experience with tropical diseases. The utilization of syndromic diagnosis and treatment of STIs in various parts of the world and the previous use of antibiotics make it difficult to find Donovan bodies in the cytodiagnostic and hystopathological exams, requiring the utilization of technology that is neither routine nor often accessible to confirm the hypothesized diagnosis. Therefore, it is necessary to bring medical professionals up to date about this infectious disease.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Granuloma inguinale; Review; Sexually transmitted diseases.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600015

Donovanosis treated with thiamphenicol
Provedor de dados: 55
Autores: Belda Junior,Walter; Velho,Paulo Eduardo Neves Ferreira; Arnone,Marcelo; Romitti,Ricardo.
Ten patients with donovanosis were treated with thiamphenicol for two weeks. In eight of them, included two HIV infected patients, lesions healed. The safety profile of thiamphenicol makes it a useful and cost-effective agent in the management of donovanosis. Randomized controlled trials should be conducted with these treatment options.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Azithromycin; Granuloma Inguinale; Sexually transmitted disease; Therapy; Thiamphenicol.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400002

Double-dose hepatitis B vaccination in cirrhotic patients on a liver transplant waiting list
Provedor de dados: 55
Autores: Bonazzi,Patricia R.; Bacchella,Telesforo; Freitas,Angela C.; Osaki,Karina T.; Lopes,Marta H.; Freire,Maristela P.; Machado,Marcel C.C.; Abdala,Edson.
Development of immunity to hepatitis B virus in cirrhotic patients waiting for liver transplantation is highly desirable. Though a double-dose regimen is available, little is know about its effectiveness. We examined the efficacy of double-dose hepatitis B virus vaccination in cirrhotic patients waiting for liver transplantation. We studied 43 patients who were waiting for liver transplantation. They were vaccinated with three doses of 40 mg hepatitis B vaccine at 0, 1 and 6 months; the normal dose is 20 mg. Efficacy was measured based on seroconversion of anti-HBs. Global response to the primary vaccination scheme was 67.5% (29 patients). Forty-one per cent of responders had anti-HBs titers above 1,000 IU/mL. No factors were associated with response,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaccine; Cirrhotic; Hepatitis B; Liver transplant.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400009

Double-stranded RNA viral infection in Cuban Trichomonas vaginalis isolates
Provedor de dados: 55
Autores: Fraga,Jorge; Rojas,Lázara; Sariego,Idalia; Fernández-Calienes,Aymé.
Trichomonas vaginalis can be infected with double-stranded RNA (dsRNA) viruses designated T. vaginalis virus (TVV), which may have important implications for trichomonal virulence and disease pathogenesis. We tested for TVV in 40 fresh T. vaginalis isolates from Cuban patients by total extraction of nucleic acids (DNA and RNA). TVV was detected in 22 (55%) of the 40 T. vaginalis isolates. This gives an estimate of the infection rate of Cuban T. vaginalis isolates by the dsRNA virus. Future research should focus on the association between trichomonosis symptoms and the presence of TVV.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trichomonas vaginalis; Trichomonas vaginalis virus; DsRNA virus.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600012

Dried blood spot testing for the antenatal screening of HTLV, HIV, syphilis, toxoplasmosis and hepatitis B and C: prevalence, accuracy and operational aspects
Provedor de dados: 55
Autores: Boa-Sorte,Ney; Purificação,Antônio; Amorim,Tatiana; Assunção,Lorena; Reis,Alan; Galvão-Castro,Bernardo.
Introduction:Screening for vertically transmitted infection is mandatory and must be conducted at the first prenatal consultation. The most vulnerable women's groups are those at the lowest socio-economic level. Dried blood spot testing on filter paper could represent a secure way to screen pregnant women in the prenatal period.Methods:A cross-sectional study was conducted between November 2009 and March 2010, in the Metropolitan Region of Salvador, Bahia, Brazil, to compare the accuracy of the dried blood spot in filter paper and venipuncture serological as screening methods for HIV, HTLV, VHB, VHC, Treponema pallidum, and Toxoplasma gondii during prenatal period. Results of the venous blood sample collected in tubes were considered the gold...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prenatal care; Infectious diseases; Seroprevalence; Dried blood spot testinga.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600618

Drug repositioning, a new alternative in infectious diseases
Provedor de dados: 55
Autores: Serafin,Marissa Bolson; Hörner,Rosmari.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300252

Drug resistance profile of staphylococci isolated from asymptomatic adults
Provedor de dados: 55
Autores: Medeiros,Claudia Christianne Barros de Melo; Araujo,Magna Suely Freitas de; Coutinho,Henrique Douglas Melo; Siqueira Júnior,José Pinto de; Barreto,Humberto Medeiros.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300016

Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections
Provedor de dados: 55
Autores: Otting,Kristin A.; Stover,Kayla R.; Cleary,John D.
Several studies have demonstrated that piperacillin/tazobactam produces a false-positive result for the galactomannan antigen test. However, the most recent literature has demonstrated that this interaction is no longer a concern. There is little information regarding the drug–laboratory interaction with the generics of piperacillin/tazobactam or other broad-spectrum beta-lactams, such as ceftaroline, doripenem, imipenem/cilastatin, and meropenem. The purpose of this study was to determine if a drug–laboratory interaction exists with these antibiotics. Tests showed that one lot of imipenem/cilastatin by Hospira Healthcare India Private Limited produced a false-positive result for the galactomannan antigen test. All other medications tested, including...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Piperacillin–tazobactam; Galactomannan; Beta-lactams; Drug interactiona.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500544

Duplex realtime PCR method for Epstein-Barr virus and human DNA quantification: its application for post-transplant lymphoproliferative disorders detection
Provedor de dados: 55
Autores: Fellner,María Dolores; Durand,Karina; Rodriguez,Marcelo; Irazu,Lucía; Alonio,Virginia; Picconi,María Alejandra.
INTRODUCTION: The quantification of circulating Epstein-Barr virus (EBV) DNA is used to monitor transplant patients as an early marker of Post-Transplant Lymphoproliferative Disorders (PTLD). So far no standardized methodology exists for such determination.OBJECTIVE: Our purpose was to develop and validate a real-time PCR assay to quantify EBV DNA in clinical samples from transplant recipients.METHODS: A duplex real-time PCR method was developed to amplify DNA from EBV and from a human gene. The EBV load was determined in peripheral blood mononuclear cells (PBMC), plasma and oropharyngeal tissue from 64 non-transplanted patients with lymphoid-hypertrophy (Non-Tx), 47 transplant recipients without PTLD (Tx), 54 recipients with PTLD (Tx-PTLD), and 66 blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: EBV; Real-time PCR; Viral load; PTLD.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300271

Durability of the first combined antiretroviral regimen in patients with AIDS at a reference center in Belo Horizonte, Brazil, from 1996 to 2005
Provedor de dados: 55
Autores: Ribeiro,Flávia Andrade; Tupinambás,Unaí; Fonseca,Marise Oliveira; Greco,Dirceu Bartolomeu.
Finding a better first antiretroviral regimen is one of the strategies used to improve span and quality of life of HIV/AIDS patients. 891 patients were followed during 24 months or until interruption/abandonment of treatment, changing regimen or death. At the end of 6 months, 69% of the patients were still being treated with the first regimen, 54% at 12 months, 48% at 18 months and 39% at 24 months. AZT-3TC-EFV was the most prescribed regimen and with the lesser discontinuation. NNRTI regimens showed high effectiveness and durability compared to PI regimens. Irregular medication dispensation was the only risk factor for failure/interruption of treatment in multivariate analyses. Intolerance/adverse effects were mainly responsible for first regimen...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; HAART; Durability; Efficacy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100005

Dyslipidaemia associated with the highly active antiretroviral therapy in aids patient: reversion after switching (stavudine to tenofovir and lopinavir/ritonavir to atazanavir/ritonavir)
Provedor de dados: 55
Autores: Domingos,Hamilton; Cunha,Rivaldo Venâncio da; Paniago,Anamaria Mello Miranda.
Antiretroviral therapy has been associated with hyperlipidemia in AIDS patients. This case illustrates the classic metabolic effects associated to the HAART including protease inhibitors and/or stavudine. It was showed that the management of the HAART-associated dyslipidaemia with conventional antihyperlipidemic therapy may fail, being the switching strategy the best option.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Dyslipidaemia; Switching strategy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200025

Dyslipidemia and fasting glucose impairment among HIV patients three years after the first antiretroviral regimen in a Brazilian AIDS outpatient clinic
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Neves,Mariza Barros das; Ribeiro-Rodrigues,Rodrigo; Page,Kimberly; Miranda,Angelica Espinosa.
OBJECTIVE: To evaluate the cumulative incidence of dyslipidemia and fasting glucose impairment three years after initiating the first antiretroviral (ART) regimen and the association with the type of ART regimen in an AIDS outpatient clinic in Brazil. METHODS: Retrospective cohort of HIV-1 infected patients attending an outpatient HIV clinic in Vitoria, Brazil, between January/2010 and May/2011. Data, including blood pressure, dyslipidemia (high total cholesterol and low HDL-C), fasting glucose, and cardiovascular risk by Framingham Risk Score were abstracted from medical records from clinic visits six months prior and three years after starting ART. We assessed independent associated factors for dyslipidemia using multiple logistic regression. RESULTS:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dyslipidemia; Fasting glucose; AIDS; ART; Co-morbidity.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400009

Dyslipidemia in AIDS patients on highly active antiretroviral therapy
Provedor de dados: 55
Autores: Nery,Max Weyler; Martelli,Celina Maria Turchi; Turchi,Marília Dalva.
Highly active antiretroviral therapy (HAART) reduces AIDS-related morbidity and mortality, however it has been associated with metabolic abnormalities. This study estimated the prevalence of lipid abnormalities and related factors among patients on HAART. A cross-sectional study was conducted on adult patients, in central Brazil. Patients were interviewed, and blood obtained for lipids measurement. Dyslipidemia was defined as total cholesterol (TC) &amp;gt; 240 mg/dL, low-density lipoprotein (LDL) &amp;gt; 160 mg/dL, triglycerides (TG) &amp;gt; 200 and/or high-density lipoprotein (HDL) &lt; 40 mg/dL. Multiple logistic regression analyses were performed (SPSS 13.0). One hundred and thirteen patients were recruited. Mean age was 39.3 years; 68.1% were males;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prevalence; Dyslipidemia; HIV; AIDS; HAART.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200010

Dyslipidemia in HIV-infected individuals
Provedor de dados: 55
Autores: Sprinz,Eduardo; Lazzaretti,Rosmeri Kuhmmer; Kuhmmer,Regina; Ribeiro,Jorge Pinto.
Metabolic complications continue to play a major role in the management of HIV infection. Dyslipidemia associated with HIV infection and with the use of combined antiretroviral therapy includes elevations in triglycerides, reduced high-density cholesterol, and variable increases in low-density and total cholesterol. The association between dyslipidemia and specific antiretroviral agents has been underscored. Multiple pathogenic mechanisms by which HIV and antiretroviral agents lead to dyslipidemia have been hypothesized, but they are still controversial. The potential clinical and pathological consequences of HIV-associated hyperlipidemia are not completely known, but several studies reported an increased risk of coronary artery disease in HIV-positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Dyslipidemia; Combined antiretroviral therapy; Nutrition; Public Health.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600006

Early conversion of tuberculin skin test in medical students who begin hospital practices
Provedor de dados: 55
Autores: Soto,Alonso; Huablocho,Pahola; Ulloque,Johan.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300015

Early diagnosis and management of tracheomalacia with invasive bronchopulmonary aspergillosis in an adult
Provedor de dados: 55
Autores: Jiang,Aigui; Lu,Huiyu.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200023

Early dissemination of OXA-72-producing Acinetobacter baumannii strain in Colombia: a case report
Provedor de dados: 55
Autores: Saavedra,Sandra Yamile; Cayô,Rodrigo; Gales,Ana Cristina; Leal,Aura Lucia; Saavedra,Carlos Humberto.
Nosocomial infections caused by carbapenem-resistant Acinetobacter baumannii isolates have reached epidemic levels in past decades. Currently this microorganism is responsible for outbreaks of difficult eradication and with high mortality rates worldwide. We herein report a rare case of an OXA-72-producing A. baumannii isolate colonizing a 47-year-old male patient with peritonitis due to abdominal stab wound, four years earlier than the first report of this carbapenemase in Acinetobacter pittii in Colombia. Although OXA-72 presents a low prevalence compared with OXA-23, our study demonstrated that A. baumannii isolates carrying the blaOXA-72 gene were present in the hospital environment in Colombia and could act as a reservoir for further spread to other...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acinetobacter baumannii; Carbapenem-resistance; Oxacillinase; Colombia.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600678

Early HHV-6 replication is associated with morbidity non-related to CMV infection after kidney transplantation
Provedor de dados: 55
Autores: Schroeder,Regina Barbosa; Michelon,Tatiana Ferreira; Garbin,Gabriela; Garcia,Valter; Silveira,Janaina Gomes da; Santos,Luciano; Neumann,Jorge; Keitel,Elizete.
Human herpesvirus type 6-(HHV-6) has been associated with morbidity after liver transplantation. OBJECTIVE: The aim of this study was to determine the HHV-6 seroprevalence among donor-recipient pairs, analyze the incidence of early active infection, its clinical manifestation, interaction with CMV, and the related morbidity in the first year after kidney transplantation. METHODS: 46 donor-recipient pairs had IgG evaluated by ELISA before transplantation: HHV-6(Pambio - USA) and CMV-(Roche - USA). A frozen whole blood sample collected weekly (from the 1st to the 6th week) was retrospectively tested for HHV-6 viral load (VL) determination by real time quantitative PCR (qPCR, Nanogen - Italy). Patients were preemptively surveyed for CMV by pp65 antigenemia...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus infections; Herpesvirus 6/human; DNA virus infections; Clinical diagnosis; Polymerase chain reaction.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200007

Early predictive efﬁcacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients
Provedor de dados: 55
Autores: Feng,Bo; Yang,Rui-Feng; Zhang,Hai-Ying; Luo,Bi-Fen; Kong,Fan-Yun; Rao,Hui-Ying; Jin,Qian; Cong,Xu; Wei,Lai.
Response-guided therapy is of limited use in developing countries because hepatitis C virus RNA detection by sensitive molecular methods is time- and labor-consuming and expen- sive. We evaluated early predictive efﬁcacy of serum hepatitis C virus core antigen kinetics on sustained virologic response in patients with genotype 1 hepatitis C virus during pegylated interferon plus ribavirin treatment. For 478 patients recruited, hepatitis C virus RNAs were detected at baseline, and at weeks 4, 12, 24, 48, and 72 using Cobas TaqMan. Architect hepatitis C virus core antigen was performed at baseline, and weeks 4 and 12. Predictive values of hepatitis C virus core antigen on sustained virologic response were compared to hepatitis C virus RNA. In the ﬁrst 12...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Genotype 1; HCV core antigen; HCV treatment.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400390

Early switch/early discharge opportunities for hospitalized patients with methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections in Brazil
Provedor de dados: 55
Autores: Furtado,Guilherme H.; Rocha,Jaime; Hayden,Ricardo; Solem,Caitlyn; Macahilig,Cynthia; Tang,Wing Yu; Chambers,Richard; Figueiredo,Maria Lavínea Novis de; Johnson,Courtney; Stephens,Jennifer; Haider,Seema.
ABSTRACT  Background: Early antibiotic switch and early discharge protocols have not been widely studied in Latin America. Our objective was to describe real-world treatment patterns, resource use, and estimate opportunities for early switch from intravenous to oral antibiotics and early discharge for patients hospitalized with methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections.  Materials/methods: This retrospective medical chart review recruited 72 physicians from Brazil to collect data from patients hospitalized with documented methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections between May 2013 and May 2015, and discharged alive by June 2015. Data collected included clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: IV-to-PO switch; Length of stay; Clinical criteria; Antibiotic therapy; Economics.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200086

Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
Provedor de dados: 55
Autores: Liang,Qiqiang; Huang,Man; Xu,Zhijiang.
ABSTRACT Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed. We collected 40 cases of CRKP bloodstream infections (BSIs) treated with combinations based on polymyxin B over 30 months. The primary outcome, 30-day mortality rate, was 52.5% (21/40). Early administration of polymyxin B is meant to administer the drug within 48 h of diagnosing bacteremia. Delayed administration was considered when polymyxin B was administered after 48 h of bacteremia onset. Polymyxin B duration and total dosages were similar in the two groups (11.57 days versus 11.76 days, p = 0.919; 1306.52 mg versus 1247.06 mg, p = 0.711)....
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Carbapenem-resistant Klebsiella pneumoniae bloodstream infection; Polymyxin B-based combination therapy; Drug use timing.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100060

Early-onset neonatal sepsis and the implementation of group B streptococcus prophylaxis in a Brazilian maternity hospital: a descriptive study
Provedor de dados: 55
Autores: Freitas,Felipe Teixeira de Mello; Romero,Gustavo Adolfo Sierra.
Abstract  Objectives: To describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil.  Methods: We defined EOS as a positive blood culture result obtained from infants aged ≤72 hours of life plus treatment with antibiotic therapy for ≥5 days. Incidence was calculated based on the number of cases and total live births (LB). This is a descriptive study comparing the period of 2012–2013 with the period of 2014–September 2015, before and after implementation of antibiotic prophylaxis during labor for group B streptococcus (GBS) prevention, respectively.  Results: Overall, 36 infants developed EOS among 21,219 LB (1.7 cases per 1000 LB) and 16 died (case fatality rate of 44%). From 2014, 305 vaginal-rectal swabs...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Neonatal sepsis; Group B streptococcal disease; Escherichia coli infection; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100092

Early-onset neonatal sepsis by Group B Streptococcus in a Brazilian public hospital
Provedor de dados: 55
Autores: Barbosa,Nayara Gonçalves; Reis,Heloísio dos; Mantese,Orlando Cesar; Mussi-Pinhata,Marisa Márcia; Abdallah,Vânia Olivetti Steffen; Gontijo Filho,Paulo Pinto.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600647

Ebola hemorrhagic fever outbreaks: strategies for effective epidemic management, containment and control
Provedor de dados: 55
Autores: Matua,Gerald Amandu; Wal,Dirk Mostert Van der; Locsin,Rozzano C.
Ebola hemorrhagic fever, caused by the highly virulent RNA virus of the filoviridaefamily, has become one of the world's most feared pathogens. The virus induces acute fever and death, often associated with hemorrhagic symptoms in up to 90% of infected patients. The known sub-types of the virus are Zaire, Sudan, Taï Forest, Bundibugyoand RestonEbola viruses. In the past, outbreaks were limited to the East and Central African tropical belt with the exception of Ebola Reston outbreaks that occurred in animal facilities in the Philippines, USA and Italy. The on-going outbreak in West Africa that is causing numerous deaths and severe socio-economic challenges has resulted in widespread anxiety globally. This panic may be attributed to the intense media...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ebola virus Filoviridaeinfections; Ebola hemorrhagic fever; Ebola epidemics.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300308

EBV-associated lymphoma in Bahia, Brazil
Provedor de dados: 55
Autores: Araujo,Iguaracyra; Bittencourt,Achiléa; Barbosa,Helenemarie S.; Portugal,Tatiana Gil; Freitas,Daniel; Almeida,Daniela; Mendonça,Núbia; Hummel,Michael; Foss,Hans-Dieter.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500028

Ecology of blood stream infection and antibiotic resistance in intensive care unit at a tertiary care hospital in North India
Provedor de dados: 55
Autores: Wattal,Chand; Raveendran,Reena; Goel,Neeraj; Oberoi,Jaswinder Kaur; Rao,Brijendra Kumar.
OBJECTIVE: To analyse the prevalent microorganisms and their antimicrobial resistance among intensive care unit patients in a tertiary care centre in New Delhi.METHODS: A retrospective study of all consecutive blood cultures from various intensive care unit patients in the hospital during four years (January 2008 to December 2011). Antibiotic consumption data in the intensive care units were also analysed during the same period.RESULTS: Out of the total 22,491 blood cultures processed, 2846 samples were positive and 3771 microorganisms were isolated. The blood culture positivity was estimated as 12.7% of which 67.5% were monomicrobial and 32.5% polymicrobial infections. Gram negative bacilli, Gram positive cocci, and fungi were isolated in 49%, 33%, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infection in ICU; Multi-drug resistance; Antibiotic consumption; Drug resistant Candida species.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300245

Economic evaluation of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus
Provedor de dados: 55
Autores: Vanni,Tazio.
Tipo: Info:eu-repo/semantics/other
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400001

Economic evaluation of treatments for chronic hepatitis B
Provedor de dados: 55
Autores: Wiens,Astrid; Lenzi,Luana; Venson,Rafael; Pedroso,Maria Lúcia Alves; Correr,Cassyano Januário; Pontarolo,Roberto.
The aim of this study was to conduct a cost-utility study of adefovir, entecavir, interferon alpha, pegylated interferon alpha, lamivudine and tenofovir for chronic hepatitis B in the context of Brazilian Public Health Care System. A systematic review was carried out for efficacy and safety. Another review was performed to collect utility data and transition probabilities between health states. A Markov model was developed in a time horizon of 40 years with annual cycles for three groups of: HBeAg positive, HBeAg negative, and all patients. These strategies were compared to a fourth group that received no treatment. Discount rates of 5% were applied and sensitivity analyses were performed. Tenofovir offered the best cost-utility ratio for the three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Economic evaluation; Treatments.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400006

Economic impact of treatment for surgical site infections in cases of total knee arthroplasty in a tertiary public hospital in Brazil
Provedor de dados: 55
Autores: Dal-Paz,Karine; Oliveira,Priscila RD; Paula,Adriana P de; Emerick,Maria Cristina da S; Pécora,José Ricardo; Lima,Ana Lucia LM.
The aim of this study was to estimate the additional cost of treatment of a group of nosocomial infections in a tertiary public hospital. A retrospective observational cohort study was conducted by means of analyzing the medical records of 34 patients with infection after total knee arthroplasty, diagnosed in 2006 and 2007, who met the criteria for nosocomial infection according to the Centers for Disease Control and Prevention. To estimate the direct costs of treatment for these patients, the following data were gathered: length of hospital stay, laboratory tests, imaging examinations, and surgical procedures performed. Their costs were estimated from the minimum values according to the Brazilian Medical Association. The estimated cost of the antibiotics...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hospital acquired infection; Surgery; Costs.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400008

Effect of citrinin and in association with aflatoxin B1 on the infectivity and proliferation of Toxoplasma gondii in vitro
Provedor de dados: 55
Autores: Herzog-Soares,Joanna D'Arc A; Freire,Ronald Bastos.
Macrophages exposed to 10 mug/mL citrinin (CTR) or 0.01 mug CTR mixed with 0.04 mug aflatoxin B1 (AFB1) for a period of 2 h at 37ºC, were infected with 10(6) Toxoplasma gondii tachyzoites/muL. The parasites were treated with mycotoxins (2 h at 37ºC) before being added to the macrophage culture. The number of tachyzoites was quantified 2, 24, 48, 72 and 96 h after infection. During the first 2 hours, 59% infectivity was observed in the control. After exposure to CTR or the mixture of toxins (CTR-AFB1), macrophages were infected with 77.5% and 75% of the inoculated tachyzoites, respectively. Similarly, 72.3% of the cells were infected when cultured together with previously treated parasites. The treatment with CTR-AFB1 gave rise to 2.9 times more tachyzoites...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aflatoxins; Imunossuspression; Macrophages; Citrinin; Toxoplasma gondii.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100007

Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
Provedor de dados: 55
Autores: Costa,Luciano Bello; Ferraz,Maria Lucia Gomes; Perez,Renata M.; Ferreira,Adalgisa S.; Matos,Carla Adriana L.; Lanzoni,Valéria P.; Silva,Antônio Eduardo.
There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C virus; Liver fibrosis; Patients.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500002

Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment
Provedor de dados: 55
Autores: Treitinger,Aricio; Spada,Celso; Masokawa,Ivete Yoshico; Verdi,Júlio César Vidal; Silveira,Mariette Van Der  Sander; Luis,Magali Chaves; Reis,Marcellus; Ferreira,Silvia Inês Alejandra Cordova de Pires; Abdalla,Dulcinéia Saes Parra.
N-acetyl-L-cysteine (NAC) has been proposed as an additional therapeutic agent for AIDS patients because it reduces human immunodeficiency virus type 1 (HIV-1) replication in stimulated CD4+ lymphocytes, and it ameliorates immunological reactivity. In a randomized, 180-day, double-blind, placebo-controlled trial performed with HIV-infected patients classified as A2 and A3 according to the criteria of the Center for Disease Control and Prevention, we investigated the effects of oral administration of NAC on HIV-infected patients undergoing their first anti-retroviral therapy; viral load, CD4+ lymphocyte, lymphocyte viability and apoptosis, and TNF-alpha and IL-8 levels were determined. Sixteen patients who received anti-retroviral therapy plus a placebo...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: N-acetylcysteine; Apoptosis; Viability; HIV; Glutathione; TNF-alpha; IL-8.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500005

Effect of pathogenic yeasts on human platelet aggregation
Provedor de dados: 55
Autores: Neiva,Teresinha de Jesus Carvalho; Santos,Jairo Ivo dos.
We investigated the effects of Candida albicans, Cryptococcus neoformans and the respective culture supernatants on human platelet aggregation (PA). Both yeasts were unable to aggregate the platelets directly. On the other hand, cells of these yeasts significantly (P &lt; 0.01) inhibited PA at concentrations equal to or higher than 1 x 10(6) cells/mL for C. albicans and equal to or higher than 1 x 10(5) cells/mL for C. neoformans. When the supernatants of one-week broth cultures were added to the activated platelets no inhibition in aggregation was observed. Apparently somatic components of these yeasts, but not their metabolic products, exert an antagonistic effect on the aggregation of human platelets, possibly aiding the fungi in their evasion of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida albicans; Cryptococcus neoformans; Platelet aggregation.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600003

Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis
Provedor de dados: 55
Autores: Abboud,Cely Saad; Rao,Gauri G.; Souza,Ercilia E.; Zavascki,Alexandre P.; Kiffer,Carlos.
ABSTRACT A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3–14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6–42) days in the polymyxin with other antimicrobial combinations group (p = 0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: AKI; CRE; Polymyxins; Aminoglicosides.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100051

Effect of pulmonary hypertension on outcome of pulmonary tuberculosis
Provedor de dados: 55
Autores: Marjani,Majid; Baghaei,Parvaneh; Malekmohammad,Majid; Tabarsi,Payam; Sharif-Kashani,Babak; Behzadnia,Neda; Mansouri,Davood; Masjedi,Mohammad Reza; Velayati,Ali Akbar.
Background:This study performed at the National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran, aimed to evaluate the effect of concomitant pulmonary hypertension on the outcome of pulmonary tuberculosis.Methods:New cases of pulmonary tuberculosis were recruited for the study. Pulmonary hypertension was defined as systolic pulmonary arterial pressure ≥35 mm Hg estimated by transthoracic Doppler echocardiography. We assessed the relationship between pulmonary hypertension and mortality during the six-month treatment of tuberculosis.Results:Of 777 new cases of pulmonary tuberculosis, 74 (9.5%) had systolic pulmonary arterial pressure ≥35 mm Hg. Ten of them (13.5%) died during treatment compared to 5% of cases with pulmonary arterial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Pulmonary hypertension; Echocardiography; Survival.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500487

Effect of sustained virologic response on the incidence of hepatocellular carcinoma in patients with HCV cirrhosis
Provedor de dados: 55
Autores: Cheinquer,Nelson; Cheinquer,Hugo; Wolff,Fernando H; Coelho-Borges,Silvia.
BACKGROUND AND OBJECTIVES: Evidence suggests that sustained virologic response to interferon treatment decreases incidence of hepatocellular carcinoma in patients with hepatitis C virus cirrhosis. This study was designed to compare the incidence of hepatocellular carcinoma among cirrhotic patients exposed to interferon based treatment with or without achieving a sustained virological response, in order to evaluate the role of interferon itself in the prevention hepatocellular carcinoma. METHODS: A cohort of 85 patients with compensated hepatitis C cirrhosis was followed after treatment with interferon and ribavirin. Sustained virological response was defined as negative polymerase chain reaction assay 24 weeks after the end of treatment. Patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatocellular carcinoma; HCV interferon; Sustained virologic response; Cirrhosis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500006

Effectiveness and tolerability of direct-acting antivirals for chronic hepatitis C patients in a Southern state of Brazil
Provedor de dados: 55
Autores: Ferreira,Vinicius Lins; Borba,Helena Hiemisch Lobo; Wiens,Astrid; Pedroso,Maria Lucia Alves; Radunz,Vanessa Ferreira de Camargo; Ivantes,Cláudia Alexandra Pontes; Kuniyoshi,Aline Satie Oba; Pontarolo,Roberto.
ABSTRACT  Background This study aimed to evaluate the clinical effectiveness in terms of sustained virological response and tolerability of available second generation direct-acting antivirals in Brazilian patients.  Methods This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus, regardless of virus genotype, fibrosis stage, or prior treatment. Statistical analysis was performed to compare the effectiveness among the treatments, and also to uncover the factors influencing the achievement of sustained virological response.  Results A total of 296 patients were included in the study, with the majority receiving sofosbuvir with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; Direct-acting antivirals; Hepatitis C; Observational study.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300186

Effectiveness of a mass immunization campaign against serogroup C meningococci in children in the Federal State of Santa Catarina, Brazil
Provedor de dados: 55
Autores: Kupek,Emil; Puricelli,Rubens C. B.; Westrupp,Maria Helena B.
In addition to vaccine efficacy studies, there is a pressing need to evaluate vaccine effectiveness in a way that takes into account the limitations of health care systems in certain settings. An attempt to reach this objective was exemplified by a vaccination campaign against serogroup C meningococci in the federal state of Santa Catarina, in Brazil. A polysaccharide vaccine against serogroup C meningococci was administered to all individuals between 6 months and 14 years of age in March, 1996, in the municipalities that had the highest incidence of meningococcal disease in the previous year. All cases of the disease due to this serogroup observed in Santa Catarina during a 1-year period before and after the vaccination were included in the analysis. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaccine; Effectiveness; Meningitis; Meningococcal disease; Serogroup C; Brazil.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600006

Effectiveness of chronic hepatitis C treatment with direct-acting antivirals in the Public Health System in Brazil
Provedor de dados: 55
Autores: Holzmann,Iandra; Tovo,Cristiane V.; Minmé,Roseline; Leal,Mônica P.; Kliemann,Michele P.; Ubirajara,Camila; Aquino,Amanda A.; Araujo,Bruna; Almeida,Paulo R.L.
ABSTRACT  Introduction Chronic hepatitis C virus infection is one of the major causes of cirrhosis, hepatocellular carcinoma and liver transplantation. Treatment using direct-acting antivirals has revolutionized the treatment of hepatitis C virus, increasing long-term prognosis after cure. The goal of the present study was to evaluate the effectiveness of direct-acting antivirals in a Public Health System in southern Brazil.  Methods A retrospective study evaluated all patients with chronic hepatitis C virus infection who underwent treatment at one center of the Public Health Department of the State of Rio Grande do Sul - Brazil, according to the Brazilian Clinical Protocol and Therapeutic Guidelines. The effectiveness was assessed in terms sustained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sofosbuvir; Daclatasvir; Simeprevir; DAA; Sustained virological response.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400317

Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS
Provedor de dados: 55
Autores: Sant'Anna,Flávia Marinho; Velasque,Luciane; Costa,Marli Jane; Schmaltz,Carolina Arana; Morgado,Mariza Gonçalves; Lourenço,Maria Cristina; Grinsztejn,Beatriz; Rolla,Valéria Cavalcanti.
This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naïve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL &lt;80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naïve and 76 (53%) previously exposed. Odds ratio (OR) in naïve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; AIDS; HAART; Rifampicin; Effectiveness.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500010

Effectiveness of the actions of antimicrobial's control in the intensive care unit
Provedor de dados: 55
Autores: Santos,Edilson Floriano dos; Silva,Antonio Emanuel; Pinhati,Henrique M. Sampaio; Maia,Marcelo de O.
There are various strategies to improve the effectiveness of antibiotics in hospitals. In general, the implementation of guidelines for appropriate antibiotic therapy and the participation of infectious disease (ID) physicians deserve considerable attention. This study was a prospective ecological time-series study that evaluates the effectiveness of the ID physician's opinion to rationalize and control the use of antibiotics in medical-surgical intensive care units (ICU), and the impact of their intervention on treatment expenditures. There was significant change in the pattern of use of antimicrobials, this pattern approximating that of a medical-surgical ICU that participates in the ICARE (Intensive Care Antimicrobial Resistance Epidemiology) Project....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Cost control; Infection control; Drug resistance; Microbial.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500002

Effectiveness of the BDProbeTec ET system for detection of Mycobacterium tuberculosis complex in sputum and bronchoalveolar lavage specimens
Provedor de dados: 55
Autores: Hung,Hung-Chang; Chan,Chi-Ho; Tsao,Shih-Ming; Chen,Shiuan-Chih; Wu,Tzu-Chin; Lu,Min-Chi; Wu,Der-Jinn; Huang,Shu-Ju; Lee,Yuan-Ti.
OBJECTIVE: The diagnostic efficacy of the BDProbeTEC ET Mycobacterium tuberculosis (MTB) complex direct detection assay (DTB) performed on bronchoalveolar lavage (BAL) specimens and sputum smears was compared with acid-fast bacilli (AFB) smear microscopy. METHOD: AFB smear microscopy, DTB and culture results of 286 patients with pulmonary tuberculosis were retrospectively reviewed. A total of 120 patients provided expectorated sputum samples, and 166 patients provided BAL specimens. Culture results and clinical diagnosis were used as gold standards. RESULTS: The sensitivity and specificity of the DTB assay in detecting MTB in sputum specimens was significantly higher compared to AFB smear microscopy (83.7% and 82.4%, vs. 75.6%, and 41.2%, respectively)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bronchoalveolar lavage; Mycobacterium tuberculosis; Acid-fast bacilli staining; Molecular diagnosis; BDProbeTEC ET system.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300005

Effectiveness of the prevention of mother-to-child HIV transmission in Bahia, Brazil
Provedor de dados: 55
Autores: Patricio,Fátima Rejane Lemos; Rutherford,George Williams; Barreto,José Henrique Silva; Rodamilans,Cynthia; Badaró,Roberto.
ABSTRACTINTRODUCTION: Antiretroviral therapy and prophylaxis during the antepartum, intrapartum and postpartum periods, cesarean delivery and avoidance of breast milk significantly reduce vertical transmission of HIV.OBJECTIVE:To evaluate the effectiveness prevention of mother-to-child transmission of HIV and determine the rate of vertical transmission in a public sexually transmitted infection and HIV referral center in Salvador, Bahia, in the period immediately prior to the initiation of universal antiretroviral therapy in pregnant women.METHODS:Cross-sectional study using data collected from medical records of children born to HIV infected mothers in Bahia from 2005 to 2008 who were referred to the Reference Center for Diagnosis and Research of Sexually...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Vertical transmission; Effectiveness; Brazil.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500538

Effectiveness, safety and tolerability of gatifloxacin, a new 8-methoxyfluoroquinolone, in the treatment of outpatients with community-acquired pneumonia: a Brazilian study
Provedor de dados: 55
Autores: Franca,Suelene Aires; Carvalho,Carlos Roberto Ribeiro.
OBJECTIVES: Evaluation of the effectiveness, safety and tolerability of gatifloxacin in the treatment of outpatients with community-acquired pneumonia (CAP). STUDY DESIGN: A prospective, multicenter, non-comparative clinical study carried out in Brazil. Voluntary, unpaid physician participation contributed to an unbiased study design. PATIENTS: Adult outpatients with clinical diagnosis of CAP. REGIMEN: Gatifloxacin, 400 mg PO once daily for 7 to 14 days. STUDY PROCEDURES: Initial clinical assessment, at the first day of gatifloxacin therapy; final evaluation after 7 to 14 days of treatment. RESULTS: According to the physicians' assessments 97.3% of patients were cured or improved after gatifloxacin treatment. The incidence of adverse events was low and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gatifloxacin; Community-acquired pneunonia; Brazilian study.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400002

Effects of a bundled Antimicrobial Stewardship Program on mortality: a cohort study
Provedor de dados: 55
Autores: Okumura,Lucas Miyake; Silva,Monica Maria Gomes da; Veroneze,Izelandia.
Objectives: To assess a bundled Antimicrobial Stewardship Program and its effect on mortality. Data:Eight months of clinical electronic medical records and Antimicrobial Stewardship Program registries were used as source of data.Method: This is a historical cohort study conducted in a Brazilian University Hospital. Eligible patients were admitted to general wards or intensive care units and had an antimicrobial therapy prescribed and assessed by different strategies: Bundled Antimicrobial Stewardship Program (bundled intervention consisted of clinical pharmacist chart review, discussion with microbiologist and infectious disease physicians, local education and continuous follow-up) or Conventional Antimicrobial Stewardship Program (clinical pharmacist...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial Stewardship; Antimicrobial Defined Daily; Dose Cohort.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300246

Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants
Provedor de dados: 55
Autores: El Beitune,Patrícia; Duarte,Geraldo; Campbell,Oona; Quintana,Silvana Maria; Rodrigues,Laura C.
This study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to mothers taking zidovudine + lamivudine + nelfinavir (TT group, n = 22) and infants born to normal women (control group, n = 12). Umbilical cord blood from the newborn infant was used to determine liver transaminases and amylase. Data were analyzed statistically by nonparametric tests, with the level of significance set at p&lt;0.05. The median levels for TT group newborns were 33.3 U/L for oxaloacetic transaminase, 21.5 U/L for pyruvic transaminase, 1.9 mg/dL for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Combination antiretroviral therapy; Hypothesis generation; Infant toxicity; Umbilical cord blood.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300003

Effects of Epstein-Barr virus on the development of dendritic cells derived from cord blood monocytes: an essential role for apoptosis
Provedor de dados: 55
Autores: Wang,Juan-Juan; Li,Yu-Feng; Jin,Ying-Ying; Wang,Xi; Chen,Tong-Xin.
OBJECTIVE: Epstein-Barr virus (EBV) is a ubiquitous human γ-herpes virus, which can adapt and evade host immune defense. Dendritic cells (DCs) play a pivotal role in the initiation and maintenance of immune responses. This study investigated the effects of EBV on cord blood monocytes derived DCs (CBDC). METHODS: Monocytes were isolated from cord blood and cultured in medium containing recombinant IL-4 and GM-CSF to induce DCs development. B95-8 supernatant was added in monocytes culture medium for EBV infection at day 0. Phenotypic characterization of DCs, apoptotic cells, and mitochondrial membrane potential (MMP) were detected by flow cytometry. The morphology was observed by Hoechst 33258 staining and TUNEL staining, the expression of X-linked inhibitor...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dendritic cells; Apoptosis; Epstein-Barr virus infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100004

Effects of hydrogen peroxide mouthwash on preventing ventilator-associated pneumonia in patients admitted to the intensive care unit
Provedor de dados: 55
Autores: Nobahar,Monir; Razavi,Mohammad Reza; Malek,Farhad; Ghorbani,Raheb.
Abstract  Aims The aim of the study was to determine the effect of hydrogen peroxide (HP) mouthwash on the incidence of ventilator associated pneumonia (VAP) in patients admitted to the intensive care unit (ICU).  Methods This was a randomized clinical trial conducted on 68 patients. The intervention group used 3% HP as mouthwash and the control group used mouthwashes with 0.9% normal saline (NS) twice a day. Data were collected using a questionnaire and the Modified Clinical Pulmonary Infection Score (MCPIS). MCPIS includes five items, body temperature: white blood cell count, pulmonary secretions, the ratio of pressure of arterial oxygen (PaO2) to fraction of inspired oxygen (FiO2), and the chest X-ray. Each of these items scored 0–2. Scores ≥6 were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infection; Ventilator associated pneumonia; Hydrogen peroxide; Intensive care unit.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500444

Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China
Provedor de dados: 55
Autores: Gui,Qifeng; Yang,Yunmei; Zhang,Jiajia.
ABSTRACT This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups: a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for &lt;1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mortality; Organ dysfunction; Older adults; Sepsis; Statins.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300255

Effects of sub-minimum inhibitory concentrations of ciprofloxacin on biofilm formation and virulence factors of Escherichia coli
Provedor de dados: 55
Autores: Dong,Guofeng; Li,Jiahui; Chen,Lijiang; Bi,Wenzi; Zhang,Xiaoxiao; Liu,Haiyang; Zhi,Xiaoyang; Zhou,Tieli; Cao,Jianming.
ABSTRACT  Objective: To evaluate the influence of sub-minimum inhibitory concentrations (MICs) of ciprofloxacin (CIP) on biofilm formation and virulence factors of Escherichia coli clinical isolates.  Methods: Sub-MICs of CIP were determined using growth curve experiments. The biofilm-forming capacity of E. coli clinical isolates and E. coli ATCC 25922 treated or untreated with sub-MICs of CIP was assessed using a crystal violet staining assay. The biofilm structure of E. coli isolate was assessed with scanning electron microscopy (SEM). The expression levels of the virulence genes fim, usp, and iron and the biofilm formation genes of the pgaABCD locus were measured using quantification RT-PCR (qRT-PCR) in E. coli isolates and E. coli ATCC 25922.  Results:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biofilm formation; Ciprofloxacin; Escherichia coli; Sub-minimum inhibitory concentration; Virulence.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100015

Efficacy and safety of Efavirenz in HIV patients on Rifampin for tuberculosis
Provedor de dados: 55
Autores: Pedral-Sampaio,Diana B.; Alves,Carmosina R.; Netto,Eduardo M.; Brites,Carlos; Oliveira,Adriano S.; Badaro,Roberto.
Forty-nine AIDS patients, most of who were antiretroviral therapy (ARV) naïve, with active tuberculosis, were treated with Rifampin 600mg, Isoniazid 400mg and Pirazinamide 2g daily. They also received ARV, consisting of Efavirenz (600mg/day) plus 2 NRTIs. All patients were prospectively followed for at least 24 months. Baselines were: male/female ratio 2:1, mean age 34.7 ± 9.4 yrs; weight 51 ± 9.0 kg, viral load 5.6 ± 0.6 logs, CD4 cell count 101 ± 128 cells/ mm³. Follow up mean values of data logs of VL and CD4+ cell /mm³ counts were: VL 1.7 and CD4+ 265; VL 1.3 and CD4+ 251; VL 1.4 and CD4+ 326 at 6, 12 and 24 months, respectively. Weight gain changes were: 5 ± 9.9 ± 12 and 21 ± 16 kg respectively at 6, 12 and 24 months. A non-concomitant ARV regimen was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; HIV/AIDS; Drug interaction; Rifampin; Efavirenz; Antiretroviral therapy.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300004

Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
Provedor de dados: 55
Autores: Moreira,Marina; Freitas,Marise R.; Martins,Sinaida T.; Castelo,Adauto; Medeiros,Eduardo Alexandrino Servolo.
Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Methicillin-resistant Staphylococcus aureus; Intensive care unit infections.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100015

Efficacy of amphotericin B in a fat emulsion for the treatment of cryptococcal meningitis in AIDS patients
Provedor de dados: 55
Autores: Rubio,Fernando Góngora; Zanon,Jeferson Rodrigo; Almeida,Margarete Teresa Gottardo de; Góngora,Delzi Vinha Nunes de.
Several formulae have been developed in an attempt to reduce the toxicity of amphotericin B (AmB), but their high costs preclude widespread use. The aim of this study was to evaluate the efficacy of amphotericin B in a fat emulsion, i.e. Intralipid (AmB-IL), in 37 AIDS patients with cryptococcal meningitis (CM). We retrospectively reviewed data collected in a non-comparative open study between January 1999 and December 2001. The therapeutic cure was defined as complete resolution or improvement of the clinical symptoms or complete absence or improvement of the mycological alterations of the CSF. The outcomes were evaluated at 2 weeks, induction phase (IP), and at the end of treatment or consolidation phase (CP) with the last available CSF. Prior to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphotericin B; Fat emulsion; Cryptococcal meningitis; AIDS patients.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200006

Efficacy of cytology for the diagnosis of Chlamydia trachomatis in pregnant women
Provedor de dados: 55
Autores: Cornetta,Maria da Conceição de Mesquita; Gonçalves,Ana Katherine da Silveira; Bertini,Anna Maria.
This study evaluated the effectiveness of Papanicolaou staining for the initial diagnosis of Chlamydial infection in pregnant women. A hundred thirteen patients were examined with a Papanicolaou test, independent of gestational age, parity or maternal age. Three endocervical samples were collected; the first two were collected with a brush (Cytobrush plus, Mediscand, Sweden) and the third with Ayre's spatula. The first specimen was used for McCoy cell culture and the other two were examined cytologically. Chlamydial infection was detected in 9 (7.9%) patients. Only one (0.8%) was diagnosed by cytological exam. The sensitivity and specificity of the cytological examination were 10 and 98%, respectively. The estimated positive predictive value was 33.3% and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Pregnancy; Infection; And cervical cytology.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500007

Efficacy of Entecavir therapy in elderly patients with chronic hepatitis B infection
Provedor de dados: 55
Autores: Tan,You-wen; Ge,Guo-hong; Sun,Li; Zhou,Xing-bei; Peng,Pen-li; Chen,Li.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600691

Efficacy of tigecycline, polymyxin, gentamicin, meropenem and associations in experimental Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae non-lethal sepsis
Provedor de dados: 55
Autores: Toledo,Paula Virginia Michelon; Tuon,Felipe Francisco; Arend,Lavinia; Aranha Junior,Ayrton Alves.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500574

Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections
Provedor de dados: 55
Autores: Ortiz-Covarrubias,Alejandro; Fang,Edward; Prokocimer,Philippe G.; Flanagan,Shawn D.; Zhu,Xu; Cabré-Márquez,Jose Francisco; Tanaka,Toshiaki; Passarell,Julie; Fiedler-Kelly,Jill; Nannini,Esteban C.
Abstract Acute bacterial skin and skin structure infections are caused mainly by Gram-positive bacteria which are often treated with intravenous vancomycin, daptomycin, or linezolid, with potential step down to oral linezolid for outpatients. Tedizolid phosphate 200 mg once daily treatment for six days demonstrated non-inferior efficacy, with a favourable safety profile, compared with linezolid 600 mg twice daily treatment for 10 days in the Phase 3 ESTABLISH-1 and -2 trials. The objective of the current post-hoc analysis of the integrated dataset of ESTABLISH-1 and -2 was to evaluate the efficacy and safety of tedizolid (N = 182) vs linezolid (N = 171) in patients of Latino origin enrolled into these trials. The baseline demographic characteristics of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ABSSSI; Latino ethnicity; Oxazolidinone; Tedizolid.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200184

Efﬁcacy of polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infections: a systematic review and meta-analysis
Provedor de dados: 55
Autores: Ni,Wentao; Cai,Xuejiu; Wei,Chuanqi; Di,Xiuzhen; Cui,Junchang; Wang,Rui; Liu,Youning.
In recent years, carbapenem-resistant Enterobacteriaceae has become endemic in many countries. Because of limited treatment options, the abandoned "old antibiotics", polymyxins, have been reintroduced to the clinic. To evaluate the clinical efﬁcacy of polymyxins in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae , we systemically searched the PubMed, Embase, and Cochrane Library databases and analyzed the available evidence. The Preferred Reporting Items for Systematic reviews and Meta-Analysis statement were followed, and the I 2 method was used for heterogeneity. Nineteen controlled and six single-arm cohort studies comprising 1086 patients met the inclusion criteria. For controlled studies, no signiﬁcant difference was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polymyxin; Enterobacteriaceae; Carbapenem-resistant; Carbapenemase-producing.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200170

Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease
Provedor de dados: 55
Autores: Hong,Ji Young; Jang,Sun Hee; Kim,Song Yee; Chung,Kyung Soo; Song,Joo Han; Park,Moo Suk; Kim,Young Sam; Kim,Se Kyu; Chang,Joon; Kang,Young Ae.
Abstract Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p &lt; 0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p = 0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbohydrate antigen 19-9; Nontuberculous mycobacteria; Tuberculosis; Biological marker.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100026

Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years
Provedor de dados: 55
Autores: Rossi,Flávia; Girardello,Raquel; Cury,Ana Paula; Di Gioia,Thais Sabato Romano; Almeida Jr,João Nóbrega de; Duarte,Alberto José da Silva.
Abstract Colistin resistance involving Gram-negative bacilli infections is a challenge for health institutions around of the world. Carbapenem-resistance among these isolates makes colistin the last therapeutic option for this treatment. Colistin resistance among Enterobacteriaceae, Acinetobacter spp., and Pseudomonas spp. was evaluated between 2010 and 2014 years, at Hospital das Clínicas, São Paulo, Brazil. Over five years 1346 (4.0%) colistin resistant Gram-negative bacilli were evaluated. Enterobacteriaceae was the most frequent (86.1%) pathogen isolated, followed by Acinetobacter spp. (7.6%), and Pseudomonas spp. (6.3%). By temporal analysis there was a trend for an increase of colistin resistance among Enterobacteriaceae, but not among...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Colistin-resistant; Polymyxin B-resistant; Enterobacteriaceae; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100098

Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
Provedor de dados: 55
Autores: Fehlberg,Lorena C.C.; Carvalho,Albalucia M.C.; Campana,Eloiza H.; Gontijo-Filho,Paulo P.; Gales,Ana C.
The emergence of KPC-2 producing K. pneumoniae in hospitalized patients at the intensive care unit (ICU) of a teaching hospital located in the city of João Pessoa, Paraíba, Brazil, is reported. Seven carbapenem-resistant K. pneumoniae recovered from different body sites of infection were analyzed. Most isolates showed a multidrug-resistance phenotype. Genotypic analysis demonstrated the presence of two genotypes, with the predominance of genotype A, which belongs to ST 437. These isolates also carry the encoding genes of five other betalactamases.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Beta-lactam resistance; Modified Hodge test; Carbapenem resistance; Enterobacteriaceae.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600013

Emergence of resistant Candida in neutropenic patients
Provedor de dados: 55
Autores: Nucci,Marcio; Colombo,Arnaldo L.
Problems with resistance to antifungal drugs have emerged due to an increase in the incidence of systemic fungal infections and widespread use of antifungal agents. Accordingly, efforts have been made to develop adequate fungal susceptibility tests. The ideal test should have high intra and inter-laboratory reproducibility, good correlation with the clinical outcome, and should be easy to perform. While no such test has yet been developed, advances have been made. Over the past decade, many reports of fungal resistance have been published, most of them in AIDS patients. Though the frequency of resistant strains is still low in neutropenic cancer patients, and is mostly limited to Candida glabrata and Candida krusei, resistance to Candida albicans has also...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Resistance; Neutropenic.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300004

Emergence of VanB phenotype-vanAgenotype Enterococcus faecium clinical isolate in Bulgaria
Provedor de dados: 55
Autores: Strateva,Tanya; Atanasova,Daniela; Mitov,Ivan; Sirakov,Ivo; Katrandjieva,Antonina.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600693

Emergent diseases in emergent countries: we must study viral ecology to prevent new epidemics
Provedor de dados: 55
Autores: Ellwanger,Joel Henrique; Chies,José Artur Bogo.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400403

Emerging acute Chagas Disease in Amazonian Brazil: case reports with serious cardiac involvement
Provedor de dados: 55
Autores: Pinto,Ana Yecê das Neves; Valente,Sebastião Aldo da Silva; Valente,Vera da Costa.
Four cases of serious cardiac attacks by autochthonous Trypanosoma cruzi infection from the Brazilian Amazon are reported; three of them occurred in micro-epidemic episodes. The manifestations included sudden fever, myalgia, dyspnea and signs of heart failure. Diagnosis was confirmed by specific exams, especially QBC (Quantitative Buffy Coat) and natural xenodiagnosis. Despite treatment with benznidazol, three patients died with serious myocarditis, renal failure and cardiac tamponade. The authors call attention to the emergence of this disease and reveal a previously unknown pathogenicity of T. cruzi strains in this area, added to a non-usual transmission form.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Chagas disease; Trypanosomiasis; Cardiovascular; Brazilian Amazon; Myocarditis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600010

Emerging and reemerging diseases in Brazil: data of a recent history of risks and uncertainties
Provedor de dados: 55
Autores: Cardoso,Telma Abdalla de Oliveira; Navarro,Marli B.M. de Albuquerque.
This article discusses the emergence and reemergence of infectious diseases on the basis of a review of the literature. It shows the critical situations faced worldwide and in special Brazil's susceptible position due to its complexity, mostly represented by the mega-biodiversity of the country and its socio-economic problems directly affecting public health. It approaches the discussions around the issue with emphasis to the recommended investments in the health sector, directed to surveillance and to strengthening the epidemiological, laboratorial and clinical bases and centered on preventive and control measures in the affected areas including Biosafety.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Emerging and reemerging infectious diseases; Epidemiology; Public health; Biosafety.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400013

Emerging carbapenem-resistant Aeromonas spp. infections in Cali, Colombia
Provedor de dados: 55
Autores: Rosso,Fernando; Cedano,Jorge Andrés; Parra-Lara,Luis Gabriel; Sanz,Ana María; Toala,Alejandra; Velez,Jolian Fernando; Hormaza,María Paula; Moncada,Pablo Andrés; Correa,Adriana.
ABSTRACT  Introduction: Aeromonas species are renowned enteric pathogens with virulence determinants linked to human diseases, such as gastroenteritis, skin, soft-tissue and muscle infections, and septicemia. A recent concern of resistance in this organism has emerged, especially the presence carbapenemases. Herein we describe a case series of emerging carbapenem-resistant Aeromonas species infection in our hospital in Cali, Colombia.  Materials and methods: Cases from 2012 to 2018 are reported. Clinical data was abstracted from the clinical charts and laboratory information. Phenotypic detection of resistance was identified using the VITEK®2 system (BioMérieux) and broth microdilution MicroScan WalkAway plus System (Beckman Coulter). CARBA NP-test and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aeromonas; Aeromonas hydrophila; Carbapenems; CphA protein; Real-time polymerase chain.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500336

Emphysematous and xanthogranulomatous pyelonephritis: rare diagnosis
Provedor de dados: 55
Autores: Ramos,Lya Duarte; Lima,Marinus de Moraes; Carvalho,Maurício de; Silva Júnior,Geraldo Bezerra da; Daher,Elizabeth De Francesco.
Pyelonephritis is a pyogenic infection of renal parenchyma that involves the renal pelvis. It is generally of easy diagnosis. The present case report aims to describe two different manifestations of this infection: xanthogranulomatous pyelonephritis and emphysematous pyelonephritis, which have poor prognosis and require a more effective treatment. The two cases were women in the fiftieth and sixtieth decade of life, with diabetes mellitus and history of weight loss. The diagnosis of the renal infection was established through computed tomography and the treatment was based in surgical procedure, with favorable outcome.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Xanthogranulomatous pyelonephritis; Emphysematous pyelonephritis; Urinary tract infection; Nephrostomy; Nephrectomy; Surgery.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400011

Emphysematous cystitis: a case report
Provedor de dados: 55
Autores: Meira,Carla; Ana,Jerónimo; Oliveira,Carlos; Amaro,Augusta; Granja,Cristina.
Emphysematous Cystitis is a primary infection of the bladder with production of gas by bacteria. The infection is uncommon, still has obvious clinical importance due to its morbidity and mortality potential, as the following case enlightens. We report a clinical case of a patient admitted with acute myocardial infarction who developed an acute emphysematous cystitis, a further complication in his long and complex period of hospitalization.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Emphysematous cystitis; Urinary tract infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600025

Endocarditis by Kocuria rosea in an immunocompetent child
Provedor de dados: 55
Autores: Moreira,Jorge Salomão; Riccetto,Adriana Gut Lopes; Silva,Marcos Tadeu Nolasco da; Vilela,Maria Marluce dos Santos.
Kocuria roseabelongs to genus Kocuria(Micrococcaceaefamily, suborder Micrococcineae, order Actinomycetales) that includes about 11 species of bacteria. Usually, Kocuria spare commensal organisms that colonize oropharynx, skin and mucous membrane; Kocuria spinfections have been described in the last decade commonly affecting immunocompromised patients, using intravenous catheter or peritoneal dialysis. These patients had mainly bacteremia/recurrent sepsis. We hereby describe the case of a 10-year-old girl, immunocompetent, who had endocarditis/sepsis by K. roseawhich was identiﬁed in ﬁve different blood cultures by Vitek2 ID-GPC card (BioMérieux, France). Negative HIV serology, blood count within normal range of leukocytes/neutrophils and lymphocytes,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Infectious endocarditis; Kocuria roseaImmune system Children.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100082

Endocrine and metabolic disorders in HTLV-1 infected patients
Provedor de dados: 55
Autores: Alves,Cresio; Dourado,Luciano.
Human T-cell leukemia virus type 1 (HTLV-1) infection is endemic in Japan and several countries in South America, Caribbean and Africa. Endocrine and metabolic disorders have been variably reported to be associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Therefore, the aim of this article was to critically evaluate the current knowledge of the endocrine and metabolic disorders associated with HTLV-1 infection. The literature search used PubMed, Web of Science, and LILACS databases in the past 10 years, utilizing, in various combinations, the following keywords: HTLV-1, adult T-cell leukemia, diabetes mellitus, GLUT-1, osteoporosis, hypercalcemia, autoimmune thyroid disorders, diabetes insipidus, inappropriate antidiuretic hormone...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; Adult T-cell leukemia; Endocrine disorders; Metabolic disorders.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600011

Endothelial function and cardiovascular diseases in HIV infected patient
Provedor de dados: 55
Autores: Andrade,Ana Cristina O.; Cotter,Bruno R.
The HIV epidemic has dramatically changed the paradigm for the development of drug therapy in the last 15 years. The goal is now not only to provide an effective reduction of plasma viremia , but also to reconstitute the immune deficiency due to the progression of the disease. Significant problems with the metabolism of sugars and lipids lead to the appearance of well-documented disorders such as insulin resistance, abnormalities in lipid metabolism and lipodystrophy in those patients on prolonged therapy with antiretrovirals. The question of whether or not HAART-associated lipid disorders contribute to the premature development of coronary artery disease is of major importance for the HIV community. Endothelial injury is associated with disease-related...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human immunodeficiency virus; Endothelial dysfunction; Endothelial adhesion molecules; Antiretroviral therapy; Cardiovascular risk factors; Atherosclerosis; Coronary heart disease.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200012

End-stage renal disease due to delayed diagnosis of renal tuberculosis: a fatal case report
Provedor de dados: 55
Autores: Daher,Elizabeth De Francesco; Silva Júnior,Geraldo Bezerra da; Damasceno,Renata Trindade; Santos,Gustavo Martins dos; Corsino,Germana Alves; Silva,Sônia Leite da; Gutiérrez-Adrianzén,Oswaldo Augusto.
Renal TB is difficult to diagnose, because many patients present themselves with lower urinary symptoms which are typical of bacterial cystitis. We report a case of a young woman with renal TB and ESRD. She was admitted with complaints of adynamia, anorexia, fever, weight loss, dysuria and generalized edema for 10 months. At physical examination she was febrile (39ºC), and her abdomen had increased volume and was painful at palpation. Laboratorial tests showed serum urea=220mg/dL, creatinine=6.6mg/dL, hemoglobin=7.9g/dL, hematocrit=24.3%, leukocytes=33,600/mm³ and platelets=664,000/mm³. Urinalysis showed an acid urine (pH=5.0), leukocyturia (2+/4+) and mild proteinuria (1+/4+). She was also oliguric (urinary volume &lt;400mL/day). Abdominal echography...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; Renal tuberculosis; Extrapulmonary tuberculosis; End-stage renal disease; Chronic renal failure.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100036

Enrichment methodology to increase the positivity of cultures from body fluids
Provedor de dados: 55
Autores: Daur,Alessandra Valle; Klimak Jr.,Francisco; Cogo,Laura Lúcia; Botão,Gislene Diógenes; Monteiro,Cristina Leise Bastos; Dalla Costa,Libera Maria.
Isolation and identification of etiological agents found in body fluids can be of critical importance for the recovery of patients suffering from potentially-severe infections, which are often followed by serious sequels. Eighty-two samples of different body fluids were analyzed using two different methods: (1) the conventional culture method (agar plating) and (2) the enrichment culture technique, using the Bact/Alert® blood culture bottle. The number of positive cultures increased on average from 9.7% to 23.1% with the enrichment culture technique. Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were the most frequently isolated bacteria. The enrichment method could provide a more accurate means the identifying etiological agents.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Body fluids; Etiological agents; Enrichment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600002

Enteric parasitic infections in HIV/AIDS patients before and after the highly active antiretroviral therapy
Provedor de dados: 55
Autores: Bachur,Tatiana Paschoalette Rodrigues; Vale,Josias Martins; Coêlho,Ivo Castelo Branco; Queiroz,Telma Régia Bezerra Sales de; Chaves,Cristina de Souza.
Enteroparasites are related to gastrointestinal alterations among patients with HIV/AIDS, some causing severe manifestations in the period before the institution of the highly active antiretroviral therapy (HAART). The prevalence of enteroparasitoses in patients with HIV/AIDS seen at two hospitals in Ceará , Brazil, was compared in the pre-HAART (Group 1; n = 482) and HAART (Group 2; n = 100) eras. Fecal parasitologic examinations (FPE) were performed using the direct, Lutz, Baermann-Moraes and modified Ziehl-Neelsen methods. The following parasites were detected in Groups 1 and 2, respectively: Strongyloides stercoralis - 30.1% and 11% (p&lt;0.0001), Ascaris lumbricoides - 15.6% and 2% (p&lt;0.0001), hookworms - 13.7% and 2% (p&lt;0.0001), Trichuris...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enteric parasitic infections; HIV; AIDS; Antiretroviral therapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200004

Enterobacteriaceae resistant to third generation cephalosporins upon hospital admission: risk factors and clinical outcomes
Provedor de dados: 55
Autores: Oliveira,Mirian Cristina; Oliveira,Clara Rodrigues Alves; Gonçalves,Karine Valéria; Santos,Marciléa Silva; Tardelli,Amanda Cristina Silva; Nobre Jr.,Vandack Alencar.
Objectives: Evaluate risk factors and clinical outcomes of infections caused by Enterobacteriaceae resistant to third-generation cephalosporins present in samples collected upon hospital admission.Methods: Risk factors were evaluated using a 1:2 ratio case-control study. Influence of resistance on the appropriateness of antibiotic therapy, length of stay, and hospital mortality were prospectively evaluated. Characteristics independently associated with the presence of resistant enterobacteria were assessed by logistic regression.Results: Enterobacteria resistant to third-generation cephalosporins were quite common (26.0%). Male gender (OR: 2.66; 95% CI, 1.17-5.06; p= 0.019), invasive prosthesis (OR: 3.79; 95% CI, 1.29-11.08; p= 0.015), previous use of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterobacteriaceae; Third generation cephalosporins; Risk factors; Antibiotic resistance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300239

Enterococcal urinary tract infections in a university hospital: clinical studies
Provedor de dados: 55
Autores: Barros,Milton; Martinelli,Reinaldo; Rocha,Heonir.
Although urinary tract infections (UTI) represent the most common infection caused by enterococci, some aspects remain to be fully clarified. The aim of this study was to determine the clinical characteristics present in UTI caused by Enterococcus spp. in patients followed up at the Prof. Edgard Santos Teaching Hospital of the Federal University of Bahia. All patients consecutively examined between 1997 and 2005, who received a diagnosis of UTI caused by Enterococcus spp. were included in the study. UTI was defined as the presence of 10(5) colony-forming units per mL of urine. Standard microbiological techniques were used. During the study period, 6.2% of the urine cultures were positive for Enterococcus spp. The mean age of the patients was 48.9 years and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococcal infections; Urinary tract; Teaching hospital; Bahia; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400011

Enterococcus faecalis resistant to vancomycin and teicoplanin (VanA phenotype) isolated from a bone marrow transplanted patient in Brazil
Provedor de dados: 55
Autores: Cereda,Rosangela F.; Sader,Helio S.; Jones,Ronald N.; Sejas,Lilian; Machado,Antônia M.; Zanatta,Yara P.; Rego,Sinaida T. M. S.; Medeiros,Eduardo A. S.
We report for the first time in Brazil, a patient from whom an Enterococcus faecalis VanA phenotype was isolated. Glycopeptide resistance is not commonly observed in Enterococcus faecalis, so this finding is of great concern since this species is responsible for 90% of enterococcal infections in Brazil. The isolate was recovered from a surveillance rectal swab culture from a patient with acute lymphocytic leukemia (ALL). Identification to the species level was performed by conventional biochemical tests and Vitek GPI cards. Antimicrobial susceptibility testing was evaluated by use of broth microdilution and Etest (AB BIODISK, Solna, Sweden) methods. The isolate was identified as E. faecalis and was considered resistant to both vancomycin (MIC, &gt; 256...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Enterococcus faecalis; Glycopeptide resistance; VanA; Initial case report; Transplant.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100007

Enteroparasitosis prevalence and parasitism influence in clinical outcomes of tuberculosis patients with or without HIV co-infection in a reference hospital in Rio de Janeiro (2000-2006)
Provedor de dados: 55
Autores: Neto,Luanda M.S.; Oliveira,Raquel de Vasconcellos Carvalhaes de; Totino,Paulo Renato; Sant'Anna,Flavia Marinho; Coelho,Viviane de Oliveira; Rolla,Valeria Cavalcanti; Zanini,Graziela M.
Tuberculosis and intestinal parasites affect primarily low social and economic level populations, living clustered in precarious habitational settings. One of the interesting aspects of this interaction is the parasitism influence in cellular response to tuberculosis. In the present study, we evaluated the prevalence of enteroparasitosis in tuberculosis patients, HIV-infected and non HIV infected, and we observed the influence of helminth presence in the response to tuberculin skin test (TST) and tuberculosis clinical outcomes. From 607 clinical records reviewed, 327 individuals met the study inclusion criteria and did not present any exclusion criteria. The prevalence of enteroparasites observed was 19.6%. There was no significant association among TST...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Intestinal parasites; Tuberculin skin test; Survival.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600008

Enterotoxins, colonization factors, serotypes and antimicrobial resistance of enterotoxigenic Escherichia coli (ETEC) strains isolated from hospitalized children with diarrhea in Bolivia
Provedor de dados: 55
Autores: Rodas,Claudia; Mamani,Rosalía; Blanco,Jorge; Blanco,Jesus Eulogio; Wiklund,Gudrun; Svennerholm,Ann-Mari; Sjöling,Åsa; Iniguez,Volga.
Enterotoxigenic Escherichia coli (ETEC) is recognized as the main cause of bacterial diarrhoea among children in Asia, Africa and Latin America but less investigated in Bolivia. OBJECTIVE: To determine the relation between enterotoxins, CFs and serotypes as well as the antimicrobial resistance patterns in a set of ETEC isolates collected from hospitalized children with acute diarrhea. In the present study we characterized 43 ETEC strains isolated from 2002 to 2006 from hospitalized children (0-5 years) with acute diarrhea in Bolivia. The strains were analyzed for heat-labile (LT) and heat-stable (ST) enterotoxins and colonization factor (CF) profiles, as well as for serogroups and antimicrobial resistance using phenotypic (ELISA, dot blot, slide...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterotoxigenic Escherichia coli; Enterotoxins; Drug resistance; Bolivia.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200007

Epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in a region of Southern Brazil where the subtype C of HIV-1 infection predominates
Provedor de dados: 55
Autores: Manenti,Sandra Aparecida; Galato Júnior,João; Silveira,Elizângela da Silva; Oenning,Roberto Teixeira; Simões,Priscyla Waleska Targino de Azevedo; Moreira,Jeverson; Fochesato,Celine Maria; Brígido,Luís Fernando de Macedo; Rodrigues,Rosângela; Romão,Pedro Roosevelt Torres.
Southern Brazil has the highest prevalence rate of AIDS in the country and is the only region in the Americas where HIV-1 subtype C prevails. OBJECTIVE: We evaluated the epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in the South region of Santa Catarina, Brazil. METHODS: All pregnant women with HIV infection attending the obstetric outpatient clinic of Criciúma, State of Santa Catarina, in 2007 (n = 46) were invited to participate. Data of 36 eligible participants were obtained through a standardized questionnaire. RESULTS: The great majority were young, with a steady partner, low family income, low education level and referring early first sexual intercourse. Many reported use of illicit non-injecting drugs (55.5%) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Serodiagnosis; HIV infections; Pregnancy; HIV-1 subtype C; Southern Brazil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400008

Epidemiologic profile of Streptococcus agalactiae colonization in pregnant women attending prenatal care in a city of southern of Brazil
Provedor de dados: 55
Autores: Kruk,Cássia Rejane; Feuerschuette,Otto Henry May; Silveira,Sheila Koetker da; Cordazo,Mayara; Trapani Júnior,Alberto.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600020

Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women
Provedor de dados: 55
Autores: Marques,Luiz Paulo José; Flores,Juliana Timóteo; Barros Junior,Onofre de Oliveira; Rodrigues,Giovana Breda; Mourão,Carla de Medeiros; Moreira,Rosa Maria Portella.
BACKGROUND: Urinary tract infections (UTIs) in elderly patients can be a complex problem in terms of approach to diagnosis, treatment, and prevention, because the patients often present nonspecific symptoms. The epidemiological and clinical characteristics of UTI in elderly women were studied, in order to make early diagnosis and prevent serious clinical complications secondary to UTI. METHODS: This was a prospective population-based study, with elderly women, during their first medical office visit. Medical records were obtained by clinical history and physical examination in order to detect signs and symptoms of UTI and the presence of comorbidities. Clean-catch midstream urine specimens for urinary dipstick test, sediment, and culture were collected;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Elderly women; Urinary tract infection; Asymptomatic bacteriuria; Risk factors; Therapy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500006

Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil
Provedor de dados: 55
Autores: Curti,Maura Cristiani de Moura; Silveira,Thaís Gomes Verzignassi; Arraes,Sandra Mara Alessi Aristides; Bertolini,Dennis Armando; Zanzarini,Paulo Donizeti; Venazzi,Eneide Aparecida Sabaini; Fernandes,Andrea Cláudia Silva; Teixeira,Jorge Juarez Vieira; Lonardoni,Maria Valdrinez Campana.
OBJECTIVE: To evaluate clinical, epidemiological and laboratorial aspects for the understanding of the disease characteristics and its relationship with diagnostic tests. METHODS: A retrospective, descriptive and analytical study involving 2,660 American cutaneous leishmaniasis (ACL) suspected patients from southern Brazil was undertaken between April 1986 and December 2005. Data on population characteristics and laboratory tests were obtained. Diagnostic laboratory tests used were direct search for Leishmania spp. (DS), Montenegro skin test (MST) and indirect immunofluorescent assay (IFA). RESULTS: 62.3% of patients were positive for at least one laboratory test. DS test was positive in 65.1%; MST in 92.3% and IFA in 70.0%. Although Cohen's Kappa test did...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clinical laboratory techniques; Disease transmission; Infectious; Cutaneous leishmaniasis; Epidemiology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100003

Epidemiological and microbiological analysis of ventilator-associated pneumonia patients in a public teaching hospital
Provedor de dados: 55
Autores: Silva Júnior,João Manoel da; Rezende,Ederlon; Guimarães,Thaís; Campos,Edvaldo V. dos; Magno,Luiz André; Consorti,Lívia; Pereira,Renata Andréa Pietro; Nascimento,Maria de Lourdes; Mendonça,João Silva de.
Ventilator-associated pneumonia (VAP) is the most commonly-acquired infection in patients in intensive care units. We analyzed epidemiological and microbiological characteristics and the outcome, in a cohort of critically-ill patients with confirmed diagnosis of VAP. All patients who had been on mechanical ventilation (MV) for more than 48 hours were included in our study; material collection for microbiological analysis was done within the first 24 hours after beginning treatment or after changing antibiotics. There were 55/265 (20.7%) VAP cases diagnosed, at a rate of 21.6 episodes per 1,000 days of mechanical ventilation. Mean age of the patients was 66 years, with a mean APACHE II score of 26.7 + 7.0; male patients were more prevalent. The mortality...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator-associated pneumonia; Epidemiology; Microbiology.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500009

Epidemiological and microbiological aspects of acute bacterial diarrhea in children from Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Diniz-Santos,Daniel R.; Santana,José S.; Barretto,Junaura R.; Andrade,Maria Goreth M.; Silva,Luciana R.
In the few cases of acute childhood diarrhea that require antimicrobial therapy, the correct choice of the drug depends on detailed previous knowledge of local strains. In order to establish such parameters in our city, we reviewed the results of all 260 positive stool cultures of children between 0 and 15 years of age during two years at a pediatric tertiary care facility in Salvador, Brazil. Bacterial strains had been presumptively identified by culturing in selective media and by biochemical testing, and their antimicrobial susceptibility patterns were automatically detected by the MicroScan Walkaway System. Data about patients' sex and age, monthly distribution of the cases, pathogens isolated and their antimicrobial resistance patterns were recorded....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Antimicrobial; Resistance; Children; Epidemiology.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100013

Epidemiological and molecular characterization of community and hospital acquired Staphylococcus aureus strains prevailing in Shenyang, Northeastern China
Provedor de dados: 55
Autores: Sun,Dan Dan; Ma,Xiao Xue; Hu,Jian; Tian,Yuan; Pang,Long; Shang,Hong; Cui,Long Zhu.
In order to obtain adequate information for the treatment of methicillin resistant Staphylococcus aureus (MRSA) infections, it is crucial to identify trends in epidemiological and antimicrobial resistance patterns of local S. aureus strains. Community and hospital acquired S. aureus isolates (n = 202) were characterized using staphylococcal cassette chromosome mec (SCCmec) typing, pulse field gel electrophoresis (PFGE) analysis, spa typing and minimal inhibitory concentration (MIC) determination. The prevalence of the Panton-Valentine leukocidine (pvl) and several antibiotic resistance genes among the isolates were also detected by PCR. All of the S. aureus isolates were susceptible to vancomycin, daptomycin and linezolid. Three hospital isolates were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CA-and HA-MRSA; SCCmec; PFGE; Spa; Pvl gene.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600010

Epidemiological aspects of acquired immunodeficiency syndrome in older Brazilians: a comparative approach
Provedor de dados: 55
Autores: Carvalho,Luiz Max Fagundes de; Câmara,Fernando Portela.
OBJECTIVES: To compare epidemiological aspects of young (15 to 49 years old) and older (more than 50 years old) AIDS patients. METHODS: We analyzed 511,633 AIDS cases notified to the Brazilian Ministry of Health in the period of 1980-2008 looking at sex, age ranges, educational level and exposure category. Patients were divided into three age groups: under 15, from 15 to 49 and over 50 years old. Using a comparative approach, we analyzed data with regard to category of exposure, education (expressed in years of schooling), and sex ratio among younger (15-49) and older adults (over 50 years old). Time series data were log-transformed and normalized, and the temporal trend was evaluated. RESULTS: AIDS incidence is increasing among people over 50 years old in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency; Syndrome; Health of the elderly; Statistical analysis; Epidemiology; Risk factors.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100006

Epidemiological aspects of an infection by Brucella abortus in risk occupational groups in the microregion of Araguaína, Tocantins
Provedor de dados: 55
Autores: Ramos,Taciana Rabelo Ramalho; Pinheiro Junior,José Wilton; Moura Sobrinho,Pedro Alves de; Santana,Vânia Lúcia de Assis; Guerra,Neurisvan Ramos; Melo,Lúcio Esmeraldo Honório de; Mota,Rinaldo Aparecido.
The aim of this paper was to study some epidemiological aspects of the infection by Brucella abortus in risk occupational groups in the microregion of Araguaína, Tocantins. For antibody research, 645 serum samples were analyzed by the complement fixation test (CF). A 4.0% frequency was found (26/645) in patients' serum and among those 4.1% (23/551) were slaughterhouses employees and 8.1% (3/37) rural workers. Of the total positive samples, three (2.0%) were women and 23 (4.7%) men; ten (2.9%) were between the ages of 18 and 30, six (3.4%) between 31 and 40, and nine (8.0%) were above 41 years of age. Risk factors for brucellosis in the study groups were age, background (OR = 2.45; CI 95% = 0.98 to 6.10) and previous work conducted with production animals...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brucellosis; Epidemiology; Humans; Risk factors.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200007

Epidemiological aspects of hepatitis C in Brazil
Provedor de dados: 55
Autores: Diament,Decio.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700002

Epidemiological aspects of rotavirus infections in Minas Gerais, Brazil
Provedor de dados: 55
Autores: Silva,Maria Luzia da Rosa e; Naveca,Felipe Gomes; Carvalho,Iná Pires de.
In order to develop good polices regarding public health measures and vaccine use to prevent rotavirus induced gastroenteritis, the epidemiology of the illness in various regions of Brazil is necessary. Accordingly, this study was to detect the frequency and types of rotavirus in one city in a tropical part of Brazil. This is an epidemiological survey of pediatric gastroenteritis caused by rotavirus conducted in Juiz de Fora, Minas Gerais State, Brazil. We analyzed 656 in-patient (190) and out-patient (466) stool samples from children ages 0 to 5 years during 1998. Rotavirus detection was performed using polyacrylamide gel electrophoresis (PAGE). Rotavirus was isolated from 62/190 stool samples (32.6%) from hospitalized children and 16/466 (3.4%) from...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; Gastroenteritis; Epidemiological survey; Seasonality; Electrophoretic patterns.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400007

Epidemiological aspects of the first human autochthonous visceral leishmaniosis cases in Porto Alegre, Brazil
Provedor de dados: 55
Autores: Mahmud,Ibrahim Clós; Piassini,Letícia de Araujo Saraiva; Motta,Fabrizio; Behar,Paulo Renato Petersen; Souza,Getúlio Dornelles.
ABSTRACT Human visceral leishmaniasis is a growing anthropozoonosis in Brazil, and particularly in the southern region of the country. It is an infectious disease transmitted to humans, dogs and other animals in urban and rural areas of the Americas, mainly due to the bite of Lutzomya longipalpis infected with Leishmania infantum. This article aims to portray the current epidemiological situation of the human visceral leishmaniasis arrival in Porto Alegre city, located in the southern region of Brazil. It is a descriptive study, a case series and a critical review. Six human cases with human visceral leishmaniasis were notified by the date of conclusion of the study, all human visceral leishmaniasis cases were diagnosed at late stage, leading to four deaths.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Visceral leishmaniasis; Fever caused by sandflies; Communicable diseases; Leishmania infantum.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200124

Epidemiological characteristics of seven respiratory viruses among pediatric patients with acute respiratory tract infections from 2011 to 2015 in Dongguan, Southern China
Provedor de dados: 55
Autores: Xie,Mingyu; Ma,Qiang; Chen,Xiuying; Lu,Xiaomei; Zhong,Baimao.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400486

Epidemiological evolution of vertical HIV transmission in Rondônia, Brazil
Provedor de dados: 55
Autores: Vieira,Gabriel de Deus; Alves,Thaianne da Cunha; Sousa,Camila Maciel de.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500017

Epidemiological profile of leishmaniasis at a reference service in the state of Alagoas, Brazil, from january 2000 to september 2008
Provedor de dados: 55
Autores: Nunes,Willian da Silva; Araújo,Sócrates Rios; Calheiros,Cláudia Maria Lins.
Leishmaniasis is a parasitic disease found in the continents of Europe, Asia, Africa and the Americas. In Brazil, the disease is an important public health problem, occurring in most states, but mainly in the Northeast region of the country, with the state of Alagoas having a significant number of confirmed cases. The present study establishes and discusses the epidemiological profile of cases of leishmaniases treated at the Reference Center of Alagoas, Hospital Escola Hélvio de Farias Auto, between January 2000 and October 2008. During thisperiod, records of 2,104 patients notified to the hospital Epidemiological Surveillance Center were reviewed. The epidemiology of leishmaniasis, both visceral and tegumentary, has shown a profile that has changed over...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: American tegumentary leishmaniasis; Visceral leishmaniasis; Epidemiology.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400005

Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil
Provedor de dados: 55
Autores: Antoniolli,Luciana; Rodrigues,Camila; Borges,Rafael; Goldani,Luciano Z.
ABSTRACT  Background: There is little information on herpes zoster from hospital registries in South America. The aim of this study was to describe the epidemiological and clinical aspects of herpes zoster (HZ) in hospitalized patients.'  Methods: We searched for hospital-based records during the period from March 2000 to January 2017 in a 700-bed tertiary-care hospital located in southern Brazil. The medical records of all eligible patients were reviewed, and data regarding demographics, medical history, clinical and laboratory characteristics, treatment regimens, and clinical outcomes were collected. Patients were also evaluated for mortality.  Results: There were 801 records of herpes zoster according to the proposed criteria. Most patients with HZ...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Herpes zoster; Clinical manifestations; Epidemiology; Treatment.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200143

Epidemiology and surveillance of methicillin-resistant staphylococcus aureus in Latin America
Provedor de dados: 55
Autores: Mejía,Carlos; Zurita,Jeannete; Guzmán-Blanco,Manuel.
Surveillance systems monitoring the spread and divergence of methicillin-resistant Staphylococcus aureus (MRSA) strains are critical if preventive and therapeutic measures targeting MRSA infection are to be employed optimally. Surveillance provides information on the spread of MRSA, on the emergence of new strains within hospitals and communities, on the antibiotic resistance profile and virulence of strains, and on the risk factors associated with infection. These data help clinicians to provide appropriate empiric treatment of infections circulating in their region, leading to improved patient outcomes. While information on MRSA epidemiology in Latin America is growing, significant gaps exist in the available data, especially in local areas where fewer...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Epidemiology surveillance Latin America resistance.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800003

Epidemiology of AIDS-related malignancies in Bahia
Provedor de dados: 55
Autores: Netto,Eduardo M; Luz,Estela; Brites,Carlos.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500015

Epidemiology of Clostridium difﬁcile: a hospital-based descriptive study in Argentina and Mexico
Provedor de dados: 55
Autores: Lopardo,Gustavo; Morﬁn-Otero,Rayo; Moran-Vazquez,Iliana Isabel; Noriega,Fernando; Zambrano,Betzana; Luxemburger,Christine; Foglia,Ginamarie; Rivas,Enrique Eduardo.
A prospective study was conducted in four tertiary hospitals in Argentina and Mexico in order to describe the occurrence of Clostridium difﬁcileinfection (CDI) in these settings. The objective was to evaluate the incidence of CDI in at-risk populations in Argentina (one center) and Mexico (three centers) and to further explore potential study sites for vaccine development in this region. A prospective, descriptive, CDI surveillance study was conducted among hospitalized patients aged ≥40 years who had received ≥48 h of antibiotic treatment. Stool samples were collected from those with diarrhea within 30 days after starting antibiotics and analyzed for toxins A and B by ELISA, and positive samples were further tested by toxinogenic culture and restriction...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium infections; Epidemiology; Latin America; Incidence.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100008

Epidemiology of healthcare-associated infections among patients from a hemodialysis unit in southeastern Brazil
Provedor de dados: 55
Autores: Albuquerque,Silvia Eduara Kennerly de; Cavalcante,Ricardo de Souza; Ponce,Daniela; Fortaleza,Carlos Magno Castelo Branco.
Patients submitted to hemodialysis are at a high risk for healthcare-associated infections (HAI). Presently there are scarce data to allow benchmarking of HAI rates in developing countries. Also, most studies focus only on bloodstream infections (BSI) or local access infections (LAI). Our study aimed to provide a wide overview of HAI epidemiology in a hemodialysis unit in southeastern Brazil. We present data from prospective surveillance carried out from March 2010 through May 2012. Rates were compared (mid-p exact test) and temporally analyzed in Shewhart control charts for Poisson distributions. The overall incidence of BSI was 1.12 per 1000 access-days. The rate was higher for patients performing dialysis through central venous catheters (CVC), either...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Infection control; Hemodialysis; Bloodstream infections; Catheter-related infections.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300327

Epidemiology of HIV/HCV coinfection in patients cared for at the Tropical Medicine Foundation of Amazonas
Provedor de dados: 55
Autores: Victoria,Marilú Barbieri; Victoria,Flamir da Silva; Torres,Kátia Luz; Kashima,Simone; Covas,Dimas Tadeu; Malheiro,Adriana.
The association of HIV infection and hepatitis C virus (HCV) infection often occurs because both viruses share the same transmission routes, increasing the possibility of HIV/HCV coinfection. World prevalence greater than 30% of coinfected cases is estimated, and it can reach 90% depending on the transmission route. With the aim of determining the frequency and profile of HIV/HCV coinfected patients, a descriptive analysis was carried out with patients with HIV/AIDS whose serology was positive for hepatitis C virus (HCV), cared for at the Fundação de Medicina Tropical do Amazonas from 2000 to 2007. In the present study, of the 2,653 AIDS cases notified in SINAN, 1,582 patients underwent serology test for hepatitis C, and a frequency of 4.42% (n = 70) of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coinfection; Hepatitis C; HIV; Epidemiology; Transmission.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200004

Epidemiology of pathogens causing urinary tract infections in an urban community in southern Brazil
Provedor de dados: 55
Autores: Reu,Carlos E.; Volanski,Waldemar; Prediger,Karoline C.; Picheth,Geraldo; Fadel-Picheth,Cyntia M.T.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600505

Epidemiology of septic arthritis of the knee at Hospital das Clínicas, Universidade de São Paulo
Provedor de dados: 55
Autores: Helito,Camilo Partezani; Noffs,Guilherme Guelfi; Pecora,Jose Ricardo; Gobbi,Riccardo Gomes; Tirico,Luis Eduardo Passarelli; Lima,Ana Lucia Munhoz; de Oliveira,Priscila Rosalba; Camanho,Gilberto Luis.
Background:Septic arthritis is an infrequent disease although very important due to the possibility of disastrous outcomes if treatment is not adequately established. Adequate information concerning the epidemiology of septic arthritis is still lacking due to the uncommon nature of the disease as well as the struggle to establish a correct case-definition.Objective:To epidemiologically characterize the population seen at Hospital das Clínicas, University of São Paulo with a diagnosis of septic arthritis between 2006 and 2011.Methods:Sixty-one patients diagnosed with septic arthritis of the knee between 2006 and 2011 were retrospectively evaluated. The patients' clinical and epidemiological characteristics, the microorganisms that caused the infection and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Knee; Infection; Septic arthritis; Epidemiology.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100028

Epidemiology of Staphylococcus aureus infections and nasal carriage at the Ibn Rochd University Hospital Center, Casablanca, Morocco
Provedor de dados: 55
Autores: Zriouil,Sanaâ Bouhali; Bekkali,Mohammed; Zerouali,Khalid.
Infections caused by Staphylococcus aureus are a major problem in hospitals. The multidrug resistance and the nasal carriage of S. aureus play a key role in the epidemic of these infections. In this prospective study, 160 S. aureus strains were isolated from pathological samples of patients (79 cases) and nasal swabs (81) of cases and controls from January to July 2007. The susceptibility to 16 antibiotics, including cefoxitin, was determined by the agar diffusion method, and methicillin resistance was confirmed by amplifying the mecA gene by polymerase chain reaction (PCR). The prevalence of methicilin-resistant S. aureus (MRSA) was high in the burns (57.7%) and dermatology (39.4%) wards, and the MRSA strains isolated were extremely multi-resistant, but...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Drug resistance; Methicillin-resistant; Staphylococcus aureus; Nasal cavity; Staphylococcal infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300011

Epidemiology of virus-associated cancers in Brazil
Provedor de dados: 55
Autores: Hassan,Rocío.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500014

Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
Provedor de dados: 55
Autores: Sánchez-Burgos,Gilma; Herrera-Nájera,Carla; Cedillo-Rivera,Roberto; Dumonteil,Eric.
ABSTRACT The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. This finding suggests that the low antibody response against P5 epitope could be a risk factor for higher susceptibility to dengue virus infection with warning signs, and that P5 could be a potential antigen for vaccine development.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Dengue virus; Epitopes; Peptides; Antibodies.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100085

Epstein-Barr virus DNA load and its association with Helicobacter pylori infection in gastroduodenal diseases
Provedor de dados: 55
Autores: Shukla,Sanket Kumar; Prasad,K.N; Tripathi,Aparna; Singh,Avinash; Saxena,Ashish; Ghoshal,Uday Chand; Krishnani,Narendra; Husain,Nuzhat.
Helicobacter pylori and Epstein-Barr virus (EBV) infections are common worldwide. Although H. pylori infection is a major factor in gastroduodenal diseases, its role in association with EBV infection is unknown. Objective: To study the association of H. pylori infection and EBV DNA load in patients with gastroduodenal diseases. Methods: Biopsy samples were collected from 200 adult patients [non-ulcer dyspepsia (NUD) 100, peptic ulcer disease (PUD) 50, gastric carcinoma (GC) 50] undergoing upper gastrointestinal endoscopy. H. pylori infection was diagnosed by rapid urease test, culture, histopathology, PCR and Q-PCR. EBV DNA was detected by non-polymorphic Epstein-Barr nuclear antigen-1 (EBNA-1) gene based Q-PCR. Results: In patients with GC and PUD, EBV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epstein-Barr virus infections; Stomach neoplasms; Helicobacter pylori.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600014

Epstein-Barr virus nuclear antigen-2 detection and typing in immunocompromised children correlated with lymphoproliferative disorder biopsy findings
Provedor de dados: 55
Autores: Mendes,Thiago Marques; Oliveira,Léa Campos de; Yamamoto,Lídia; Del Negro,Gilda Maria Barbaro; Okay,Thelma Suely.
Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, plays a significant role as a cofactor in the process of tumorigenesis, and has consistently been associated with a variety of malignancies especially in immunocompromised patients. Forty-four children and adolescents (21 liver transplant patients, 7 heart transplant, 5 AIDS, 3 autoimmune hepatitis, 2 nephritic syndromes, 2 medullar aplasia, 2 primary immunodeficiency disorder patients, 1 thrombocytopenic purpura and 1 systemic lupus erythematosus) presenting with chronic active EBV infection (VCA-IgM persistently positive; VCA-IgG &gt; 20 AU/mL and positive IgG _ EBNA) had peripheral blood samples obtained during clinically characterized EBV reactivation episodes. DNA samples were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: EBVA; EBNA-2; Infectious mononucleosis; Lymphoproliferative disorder; EBV genotyping; EBV-PCR.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300005

ERRATA
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/article
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500017

Erratum
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600651

Erratum
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500524

Erratum - BJID 15(5)
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/article
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100025

Erratum in «High rate of virologic supression with darunavir/ritonavir plus optimazed background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil»
Provedor de dados: 55
Autores: Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300017

Erratum on "Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma" [Braz. J. Infect. Dis. 18 (3) (2014) 315-326]
Provedor de dados: 55
Autores: Arruda,Érico; Jacome,Alexandre Andrade dos Anjos; Toscano,Ana Luiza de Castro Conde; Silvestrini,Anderson Arantes; Rêgo,André Santa Bárbara; Wiermann,Evanius Garcia; Cunha Jr.,Geraldo Felicio da; Melo,Heloisa Ramos Lacerda de; Morejón,Karen Mirna Loro; Goldani,Luciano Zubaran; Pereira Jr.,Luiz Carlos; Silva,Mariliza Henrique; Treistman,Mauro Sergio; Pereira,Mônica Cristina Toledo; Romero,Patricia Maria Bezerra Xavier; Schmerling,Rafael Aron; Guedes,Rodrigo Antonio Vieira; Camargo,Veridiana Pires de.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400468

Erratum to “Barriers to treatment of hepatitis C in HIV/HCV coinfected adults in Brazil” [Braz. J. Infect. Dis. 14 (3) (2010) 237–241]
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200226

Erratum to “Molecular epidemiology of measles virus infection in Shanghai in 2000–2012: the first appearance of genotype D8” [Braz. J. Infect. Dis. 18 (6) (2014) 581–590]
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100111

Eschar: a cutaneous clue to scrub typhus
Provedor de dados: 55
Autores: Aggarwal,Sourabh; Sharma,Alka; Sharma,Vishal.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400023

Esophageal ulcers caused by reactivation of ganglionary tuberculosis: a case report
Provedor de dados: 55
Autores: Hadlich,Everton; Galperim,Bruno; Rizzon,Carlos Fernando.
The involvement of the esophagus in tuberculosis (TB) is extremely rare. This is a case report of an immunocompetent male patient, who presented ganglionary TB reactivation, with the development of extensive esophageal ulcers. The endoscopic approach made the diagnosis possible and there was a total resolution of the symptoms after the treatment.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Esophagus; Endoscopy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200026

Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil
Provedor de dados: 55
Autores: Kallas,Esper Georges; Bassichetto,Katia Cristina; Oliveira,Solange Maria; Goldenberg,Ieda; Bortoloto,Reginaldo; Moreno,Diva Maria Faleiros C.; Kanashiro,Cecilia; Chaves,Mariana Mellilo Sauer; Sucupira,Maria Cecilia A.; Diniz,Aparecido; Mesquita,Fabio C.
Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Recent infection; Network; São Paulo.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600003

Estimated prevalence of immunity to poliomyelitis in the city of São Paulo, Brazil: a population-based survey
Provedor de dados: 55
Autores: Kiffer,Carlos Roberto Veiga; Conceição,Orlando Jorge; Santos,Edgar Bortholi; Sabino,Ester; Focaccia,Roberto.
OBJECTIVES: Estimate the prevalence of immunity to poliomyelitis (anti-polio antibodies) in the city of São Paulo/Brazil through a population-based survey. METHODS: A quantitative and inductive method was used to draw a representative sample of the population. Randomization and stratification (based on sex, age and residence region) was done, and 1,059 individuals were studied on a home-visit basis (structured questionnaires and blood samples). A microneutralization test was performed to detect anti-polio antibodies against serotypes 1, 2 and 3. RESULTS: The estimated prevalence of immunity to poliomyelitis was high, with 94.6% prevalence of anti-polio 1 antibodies, 98.8% anti-polio 2 and 91.9% anti-polio 3. Despite this high prevalence, there were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Immunity prevalence; Poliomyelitis; Poliviruses; Seroepidemiologic studies; Antibodies; Viral blood.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500004

Estimating HIV-1 incidence using the serologic testing algorithm for recent HIV infections at HIV counseling and testing centers in the city of São Paulo, Brazil
Provedor de dados: 55
Autores: Bassichetto,Katia Cristina; Bergamaschi,Denise Pimentel; Veras,Maria Amelia; Sucupira,Maria Cecilia Araripe; Mesquita,Fabio; Diaz,Ricardo Sobhie.
The network of HIV counseling and testing centers in São Paulo, Brazil is a major source of data used to build epidemiological profiles of the client population. We examined HIV-1 incidence from November 2000 to April 2001, comparing epidemiological and socio-behavioral data of recently-infected individuals with those with long-standing infection. A less sensitive ELISA was employed to identify recent infection. The overall incidence of HIV-1 infection was 0.53/100/year (95% CI: 0.31-0.85/100/year): 0.77/100/year for males (95% CI: 0.42-1.27/100/year) and 0.22/100/ year (95% CI: 0.05-0.59/100/year) for females. Overall HIV-1 prevalence was 3.2% (95% CI: 2.8-3.7%), being 4.0% among males (95% CI: 3.3-4.7%) and 2.1% among females (95% CI: 1.6-2.8%). Recent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1/immunology; HIV infections/epidemiology; HIV seroprevalence; Seroepidemiologic studies.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100004

Estimating risk factors for acinetobacter bacteremia in pediatric settings
Provedor de dados: 55
Autores: Ekinci,Faruk; Bayram,Nuri; Devrim,Ilker; Apa,Hurşit; Gülfidan,Gamze; Günay,Ilker.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400023

Estimating the length of the first antiretroviral therapy regiment durability in São Paulo, Brazil
Provedor de dados: 55
Autores: Medeiros,Roseane; Diaz,Ricardo S.; Castelo Filho,Adauto.
Brazil was the first country to provide unrestricted, cost-free access to antiretroviral (ARV) medicine for AIDS treatment. However, there is little data about the benefits of such a policy for these patients. We evaluated the duration of benefit obtained with the introduction of ARVs, defined as the durability of the first ARV regiment. We reviewed the medical charts of patients attended from 1996-2000, at the outpatient clinics of the Federal University of São Paulo, Brazil. A total of 120 drug-naive HIV-1 infected patients were eligible to participate in the study. About half of the individuals (53%) presented with disease symptoms; 59% of them had CD4 count below 200 cells/mm³. Mean estimated duration of the benefit of therapy was 14.1 months. The most...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Zidovudine; Antiretroviral therapy; São Paulo; Brazil.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600005

Estimation of the residual risk for the transmission of HIV in blood donors from the mountain region of Santa Catarina
Provedor de dados: 55
Autores: Spada,Celso; Souza,Marli Adelina; Treitinger,Arício.
The HIV, in hemotheraphy, may be transmitted by erythrocyte, platelets, crioprecipitated, frozen fresh plasma and possibly, by other blood components. Appropriate legislations for this new reality were elaborated normatizing the hemotheraphy practices in Brazil, creating a set of procedures and actions aiming at guaranteeing the quality of the blood, during, during the whole process. However, the residual risk remains, and it can be calculated as a product of the incidence and period of the immunological window. The objetive of the present study was to determine the rate of residual risk of the HIV blood transmission, in the blood donors from the Mountain Region of Santa Catarina. In order to calculate the residual risk of the HIV markers, 4,857 donors of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Blood donors; Residual risk; Transfusion security; Immunological window.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600006

Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases
Provedor de dados: 55
Autores: Zou,Xiao-ni; Zhang,Xiao-zhuang; Wang,Bo; Qiu,Yi-teng.
OBJECTIVES: This study aimed to review etiological and epidemiological data for hand, foot, and mouth disease (HFMD) cases that occurred between 2008 and 2010 in Guangzhou City, to help develop and implement precautionary measures applicable for future outbreaks. METHODS: The characteristics of 4,753 HFMD episodes were retrospectively reviewed in 4,636 patients reported between 2008 and 2010 by the Guangdong Women and Children's Hospital, which is the national enterovirus monitoring agent and the designated hospital in China for treating severe HFMD. RESULTS: Out of 4,753 incident episodes reviewed, 525 patients were hospitalized; 60% were males. Most patients (93.8%) were children under 5 years old, with a median age at onset of 2.4 years. HFMD incidence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemic Hand; Foot and mouth disease Coxsackie virus A16 Human enterovirus 71.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500010

Etiology and pathogenesis of bloodstream infections associated with the use of long-term central vascular catheter (CVC) in patients who undergone gastrointestinal surgery
Provedor de dados: 55
Autores: Brito,Cristiane Silveira; Gondim,Bruna Amâncio; Diogo Filho,Augusto; Gontijo Filho,Paulo P.
CVC is the main factor of risk of bloodstream infections. This study purpose was determining both etiology and pathogenesis of these infections in 80 patients who undergone gastrointestinal surgery and who worn long lasting CVC, in the institution HC-UFU. Cultures were made in nostril, skin of the insertion site, tip and catheter hub, in addition to hemoculture in those suspects of sepsis. The colonization incidence rate of the catheter tip was 12.5/ 1,000 catheter days and the CVC associate infection rate was 3.1/1,000 catheter days. Frequencies of skin, hub and catheter tip colonization were 13.8%, 8.9% and 13.3%, respectively. Coagulase-negative Staphylococci were the most found microorganisms in nostril (74%), skin (45.4%) and hub (75%) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infection; Central vascular catheter; Bloodstream infections.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100021

Etiology of bronchopulmonary infections in Bulgarian cystic fibrosis patients
Provedor de dados: 55
Autores: Strateva,Tanya; Petrova,Guergana; Stratev,Alexander; Perenovska,Penka; Mitov,Ivan.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500019

Etiology of childhood community acquired pneumonia and its implications for vaccination
Provedor de dados: 55
Autores: Nascimento-Carvalho,Cristiana M.C.
Pneumonia is an important cause of morbidity and mortality among children throughout the world. Vaccines are available for some organisms, but they are underutilized and/or still in development. To evaluate the potential impact of vaccines, we review studies in which the etiology of childhood community-acquired pneumonia was recorded. In North America and Europe (9 studies), the etiology of pneumonia was established in 62% of studied children (range 43%-88%) by use of noninvasive specific methods for microbiologic diagnosis. The most often identified agents were S. pneumoniae (22%), respiratory syncytial virus (RSV) (20%), Haemophilus influenzae (7%), and Mycoplasma pneumoniae (15%). In Africa and South America (8 studies), bacteria were recovered from 56%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-acquired pneumonia; Children; Etiology; Vaccine; S. pneumoniae; Respiratory syncytial virus.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200007

Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
Provedor de dados: 55
Autores: Angelo,Ana Luiza Dias; Angelo,Camila Dias; Torres,Alex José Leite; Ramos,André Maurício Costa; Lima,Márcia; Netto,Eduardo Martins; Brites,Carlos.
This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 &lt; 200 cells/mm³) and patients with CD4 &lt; 350 cells/mm³ (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm³ (range: 4 to 2,531 cells/mm³). Mean TLC was 1,900 cells/mm³ (range: 300 to 6,200 cells/mm³). Using a threshold value of 1,000 cells/mm³ for TLC, the positive predictive value (PPV) was 77% for CD4 &lt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lymphocyte counts; CD4 counts; AIDS.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500005

Evaluation of AIDS-related disability in a general hospital in southern, Brazil
Provedor de dados: 55
Autores: Zonta,Marise Bueno; Almeida,Sérgio Monteiro de; Carvalho,Mirian T Matsuno de; Werneck,Lineu César.
The increase in survival rates of patients affected by AIDS is associated with physical disabilities that can compromise their functional independence. We examined the degree and types of disabilities in hospitalized AIDS patients , as well the clinical and immunological parameters associated with disability. The lowered functional status was associated with increased time since AIDS had been diagnosed, with complaints of weakness, and with the involvement of more than one set of systems in the definition of AIDS. The inability to perform daily living activities was associated with higher viral loads (log) c/mL, lower CD4+/mL and CD4+/CD8+ ratios, and with involvement of the central nervous system, in the cause of hospitalization. Both the inability to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; Disability; Functional status; Functional assessment; Functional independence measure.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600005

Evaluation of an enzyme-linked immunospot assay for the immunodiagnosis of atypical spinal tuberculosis (atypical clinical presentation/atypical radiographic presentation) in China
Provedor de dados: 55
Autores: Yuan,Kai; Zhong,Zhao-ming; Zhang,Qiang; Xu,Shu-chai; Chen,Jian-ting.
BACKGROUND: Atypical spinal tuberculosis (TB) usually presents in a slowly indolent manner with nonspecific clinical presentations making the diagnosis a great challenge for physicians. New technologies for the detection of atypical spinal TB are urgently needed. The aim of this study was to assess the diagnostic value of an enzyme-linked immunospot (ELISPOT) assay in clinically suspected cases of atypical spinal TB in China. METHODS: From March 2011 to September 2012, a total of 65 patients with suspected atypical spinal TB were enrolled. In addition to conventional tests for TB, we used ELISPOT assays to measure the IFN-I response to ESAT-γ and CFP-10 in T-cells in samples of peripheral blood mononuclear cells. Patients with suspected atypical spinal TB...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Atypical spinal tuberculosis; Enzyme-linked immunospot assay; T-SPOT.TB kit; Diagnosis.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500004

Evaluation of annexin V and Calcein-AM as markers of mononuclear cell apoptosis during human immunodeficiency virus infection
Provedor de dados: 55
Autores: Palma,Priscila F.R.; Baggio,Giovana L.; Spada,Celso; Silva,Renata da; Ferreira,Silvia Inês A.C.P.; Treitinger,Aricio.
Evaluation of apoptosis by flow cytometry is generally accomplished by methods that use annexin V-FITC as vital dye, which access phosphatidylserine exposed on the external membrane at the beginning of this process. In addition, the concomitant use of propidium iodide makes possible to verify the characteristic nuclear alterations in the late stages of apoptosis, as a consequence of the increase in membrane permeability. On the other hand, the use of calcein-AM in association with ethidium homodimer (EthD-1) allows the evaluation of cell apoptosis through detection of esterase activity and cellular membrane physical and chemical alterations. The aim of this study was to compare the sensibility of calcein-AM and EthD-1 with annexin V-FITC and propidium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apoptosis; Flow cytometry; Annexin V; Propidium iodide; Calcein-AM; Ethidium homodimer.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200003

Evaluation of blood stream infections by Candida in three tertiary hospitals in Salvador, Brazil: a case-control study
Provedor de dados: 55
Autores: Barberino,Maria Goreth; Silva,Nanci; Rebouças,Carla; Barreiro,Katarine; Alcântara,Ana Paula; Netto,Eduardo M.; Albuquerque,Lígia; Brites,Carlos.
Invasive infections caused by Candida spp. are an important problem in immunocompromised patients. There is scarce data on the epidemiology of blood stream candidiasis in Salvador, Brazil. This study evaluates the risk factors associated with candidemia, among patients admitted to three tertiary, private hospitals, in Salvador, Brazil. We conducted a case-control, retrospective study to compare patients with diagnosis of candidemia in three different tertiary hospitals in Salvador, Brazil. Patients were matched for nosocomial, acquired infections, according to the causal agent: cases were defined by positive blood cultures for Candida species. Controls were those patients who had a diagnosis of systemic bacterial infection, with a positive blood culture to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Invasive candidiasis; Risk factors; Bacteremia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100008

Evaluation of central supply units in public dental medicine colleges in Brazil
Provedor de dados: 55
Autores: Sasamoto,Sandra Aragão de Almeida; Tipple,Anaclara Ferreira Veiga; Souza,Adenícia Custódia Silva e; Paiva,Enilza Maria M. de; Souza,Carlos de Paula e; Pimenta,Fabiana Cristina.
A guarantee of quality of all steps involved in processing dental materials is essential to achieve security. A descriptive study was made of how Public Dental Medicine Colleges in Brazil process critical materials and determine the patterns of physical, chemical and biological control in their use of hot air ovens and autoclaves to sterilize these materials. The data were obtained with a questionnaire, sent by mail and analyzed with the software EPI-INFO 6.04. Among the 40 Brazilian public Dental Medicine Colleges, only 16 returned the questionnaire. In eight of these, the individuals responsible for the materials and sterilization center had a college degree in a human health field. In 14 institutions, the students were responsible for the cleaning of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Central supply unit; Odontology; Quality control.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600009

Evaluation of different detection methods of biofilm formation in the clinical isolates
Provedor de dados: 55
Autores: Hassan,Afreenish; Usman,Javaid; Kaleem,Fatima; Omair,Maria; Khalid,Ali; Iqbal,Muhammad.
BACKGROUND: Microorganisms growing in a biofilm are associated with chronic and recurrent human infections and are highly resistant to antimicrobial agents. There are various methods to detect biofilm production like Tissue Culture Plate (TCP), Tube method (TM), Congo Red Agar method (CRA), bioluminescent assay, piezoelectric sensors, and fluorescent microscopic examination. OBJECTIVE: This study was conducted to compare three methods for the detection of biofilms. METHOD: The study was carried out at the Department of Microbiology, Army Medical College, National University of Sciences and Technology, Pakistan, from January 2010 to June 2010. A total of 110 clinical isolates were subjected to biofilm detection methods. Isolates were identified by standard...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biofilms; Bacteria; Anti-bacterial agents.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400002

Evaluation of disease patterns, treatment and prognosis of tuberculosis in AIDS patient
Provedor de dados: 55
Autores: Atomiya,Angela Naomi; Uip,David Emerson; Leite,Olavo Henrique Munhoz.
Patterns of disease, diagnosis, treatment and prognosis of tuberculosis in 100 patients co-infected with AIDS at Casa da AIDS clinic was studied. Demographic characteristics were as follows: 76 male patients, 24 female patients, 67 caucasian, average 35.8 years-old (SD ± 8.5). Sexual transmission of HIV was reported in 68 patients. Pulmonary tuberculosis was seen in 40 patients, extrapulmonary in 11, and combined in 49 patients. In 63 patients, TCD4+ counts were below 200/mm³ when tuberculosis was diagnosed. Fifty-five patients had their diagnoses confirmed by bacteriological identification of Mycobacterium; either through direct observation and/or culture. Tuberculosis was treated with rifampin, isoniazid and pyrazinamide in 60 patients, reinforced...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Tuberculosis; Rifampin; Isoniazid; Pyrazinamide.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100005

Evaluation of efficacy and safety of itraconazole oral solution for the treatment of oropharyngeal candidiasis in AIDS patients
Provedor de dados: 55
Autores: Queiroz-Telles,Flávio; Silva,Nanci; Carvalho,Miriam M.; Alcântara,Ana Paula; Matta,Daniel da; Barberino,Maria G.; Bartczak,Sergio; Colombo,Arnaldo Lopes.
This study was a non-comparative multicenter clinical trial to evaluate the efficacy and tolerability of itraconazole oral solution 200 mg/day (100 mg twice a day in the fasting state) for the treatment of oropharyngeal candidiasis in AIDS patients. We included 50 patients who were treated and followed for up to 3 weeks after ending therapy in the analysis. Mycological cures at the end of therapy occurred in 20/50 patients (40%), but colonization by Candida sp. was recorded in 42/50 (84%) by the end of follow-up. A high rate of clinical response was observed in 46/50 (92%), and the response was sustained for up to 21 days after stopping therapy in 24/46 patients (52%). Clinical relapses were documented among 22 patients, but all causative fungal organisms...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Candidiasis; Itraconazole.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200003

Evaluation of emerging infectious disease and the importance of SINAN for epidemiological surveillance of Venezuelans immigrants in Brazil
Provedor de dados: 55
Autores: Lima Junior,Mário Maciel de; Rodrigues,Gabbrielle Almeida; Lima,Maysa Ruiz de.
ABSTRACT  Background: Following socio-economic turmoil in Venezuela, millions of the Venezuelan people are migrating to the neighboring Latin American countries including Brazil. Besides the social and economic burden of these migrants, Brazil must manage the health-related issues arising as consequence of these Venezuelan migrants.Poor health services in Venezuela along with unhygienic travelling conditions, lack of food (malnutrition) and potable water, unhealthy and overcrowded refugee camps or shelters, poor availability of medical services have made the migrant Venezuelan population susceptible to various diseases, especially infectious diseases.SINAN system is a health-related system in Brazil that keeps track of different health occurrences in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Venezuela; Brazil; SINAN; Epidemiological surveillance.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500307

Evaluation of HIV/AIDS patients' knowledge on antiretroviral drugs
Provedor de dados: 55
Autores: Almeida,Regina Flávia de Castro; Vieira,Anya Pimentel Gomes Fernandes.
Lack of information on antiretroviral drugs or the misunderstanding of available information can facilitate incorrect use of such drugs. This can result in non-adherence to the prescribed regimen, leading to a great possibility of a therapeutic failure. The aim of this study was to know which information HIV/AIDS patients, who receive their medicines at the pharmacy of a reference hospital in the northeast Brazil, have on the drugs they use, the source of this information and whether there is a need for additional information. A total of 195 HIV/AIDS patients, who were using either zidovudina + lamivudina 300+150mg (AZT+3TC), efavirenz 600mg (EFZ) or lopinavir/ritonavir 133.33/33mg (LPV/r), were interviewed. The mean age was 41 years (SD = 9.55) and 70.8%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Drug information; Antiretroviral; Adherence; Non-adherence.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300006

Evaluation of in-house mpt64 real-time PCR for rapid detection of Mycobacterium tuberculosis in pulmonary and extra-pulmonary specimens
Provedor de dados: 55
Autores: Sethi,Sunil; Yadav,Rakesh; Mewara,Abhishek; Dhatwalia,Sunil Kumar; Sharma,Meera; Gupta,Dheeraj.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500019

Evaluation of late presentation for HIV treatment in a reference center in Belo Horizonte, Southeastern Brazil, from 2008 to 2010
Provedor de dados: 55
Autores: Valentini,Melissa Bianchetti; Toledo,Maria Luíza Guerra de; Fonseca,Marise Oliveira; Thiersch,Laura Maria Silva; Toledo,Ingrid Silva Bremer de; Machado,Flávia Cristina Jácome; Tupinambás,Unaí.
Introduction: Since 1996 Brazil has provided universal access to free antiretroviral therapy, and as a consequence, HIV/AIDS patients' survival rate has improved dramatically. However, according to scientific reports, a significant number of patients are still late presenting for HIV treatment, which leads to consequences both for the individual and society. Clinical and immunological characteristics of HIV patients newly diagnosed were accessed and factors associated with late presentation for treatment were evaluated.Methods: A cross-sectional study was carried out in an HIV/AIDS reference center in Belo Horizonte, Minas Gerais, in Southeastern Brazil from 2008 to 2010. Operationally, patients with late presentation (LP) for treatment were those whose...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Late presentation; HIV infection; CD4 cell count.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300253

Evaluation of oxidative status in patients with brucellosis
Provedor de dados: 55
Autores: Serefhanoglu,Kivanc; Taskin,Abdullah; Turan,Hale; Timurkaynak,Funda Ergin; Arslan,Hande; Erel,Ozcan.
Oxidative stress can be defined as an increase in oxidants and/or a decrease in antioxidant capacity. We aimed to determine total antioxidant capacity (TAC), total peroxide, malondialdehyde and catalase levels in plasma samples, and calculation of oxidative stress index (OSI) in patients with brucellosis to evaluate their oxidative status using a novel automated method. Sixty-nine patients with brucellosis and 69 healthy control subjects were included in the present study. Plasma levels of total peroxide and malondialdehyde were significantly increased in patients as compared with healthy controls (p&lt;0.001 and p&lt;0.001, respectively). In contrast, TAC level was significantly lower in patients as compared with controls (p&lt;0.001). There was no...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Brucellosis; Oxidants; Antioxidants; Oxidative stress.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400001

Evaluation of phenotypic tests to detect carbapenem-resistant Enterobacteriaceae in colonized patients hospitalized in intensive care units
Provedor de dados: 55
Autores: Perez,Leandro Reus Rodrigues; Rodrigues,Diógenes; Dias,Cícero Gomes.
In this study, we aimed to evaluate the performance of different phenotypic tests to detect carbapenem-resistant Enterobacteriaceae. Three different phenotypic methods were evaluated: (1) combined-disk test of meropenem plus phenylboronic acid or EDTA reading after 24 h and 48 h; (2) selective/chromogenic read after 24 h and after 48 h; and (3) overnight selective enrichment broth containing 10 µg ertapenem disk followed by culture on MacConkey agar. A positive result in at least one of the methods was submitted to PCR for blaNDM-1, blaOXA-48, blaKPC, blaSPM-1, blaIMP, and blaGES detection. Carbapenem-resistant Enterobacteriaceae was detected in 31 (30.4%) of 102 rectal swabs evaluated. All isolates showed to be KPC-2-producing organisms. Results showed...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Carbapenems; Enterobacteriaceae; KPC; Surveillance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400436

Evaluation of procalcitonin and neopterin level in serum of patients with acute bacterial infection
Provedor de dados: 55
Autores: Pourakbari,Babak; Mamishi,Setareh; Zafari,Javid; Khairkhah,Hanieh; Ashtiani,Mohammad H; Abedini,Masomeh; Afsharpaiman,Shahla; Rad,Soroush Seifi.
BACKGROUND: Fever as a common presenting complaint in pediatric patients can be due to various causes. Differentiating bacterial infection from other causes is important because the prompt use of antibiotics is critical in bacterial infection. Traditional markers of infection such as BT and WBC count may be unspecific and culture may be late or absent. CRP and Procalcitonin (PCT) have been considered to evaluate the evolution of infections and sepsis in patients presenting with SIRS. Neopterin has also been proposed to aid in the diagnosis of bacterial infection. In this study, we compared the value of the serum PCT, neopterin level, and WBC count for predicting bacterial infection and outcome in children with fever. METHODS: 158 pediatric...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Procalcitonin; Neopterin; SIRS.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300009

Evaluation of rapid tests for human immunodeficiency virus as a tool to detect recent seroconversion
Provedor de dados: 55
Autores: Girardi,Samira Barboza; Barreto,Angela Maria Egydio de Carvalho; Barreto,Claudia Cortese; Proietti,Anna Barbara; Carvalho,Silvia Maia Farias de; Loureiro,Paula; Sabino,Ester Cerdeira.
The identification of recent HIV infection is important for epidemiological studies and to monitor the epidemic. The objective of this study was to evaluate two rapid tests that are easily available to the Brazilian scientific community for using as markers of recent HIV infection. The Rapid Test - HIV-1/2 Bio-Manguinhos (Bio-Manguinhos/Fiocruz, Brazil) and the Rapid Check HIV 1&amp;2 (NDI-UFES, Center for Infectious Diseases, Universidade Federal do Espírito Santo) were tested, using 489 samples with HIV positive serology, from blood donors, previously classified as recent or long-term infection by serological testing algorithm for recent HIV seroconversion (STARHS) or LS-HIV Vitros assay methods. The samples were diluted prior to testing (1:50 and 1:100...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1 incidence; Detuned assay; Surveillance; Rapid test.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500009

Evaluation of reactive Epstein-Barr virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)
Provedor de dados: 55
Autores: Ramroodi,Nourollah; Niazi,Abbas Ali; Sanadgol,Nima; Ganjali,Zohre; Sarabandi,Vida.
OBJECTIVES: Epstein-Barr virus has been recently associated with the onset of multiple sclerosis, yet understanding how it elicits autoimmunity remains elusive. We investigated the relation between Epstein-Barr virus reactivation and disease development in different subtypes of multiple sclerosis. METHODS: In the present research, we have determined the Epstein-Barr virus-DNA load by quantitative real-time polymerase chain reaction and Epstein-Barr virus antibody levels by EIA technique in both multiple sclerosis patients (n = 78) and healthy controls (n = 123). RESULTS: Our results demonstrated increased titer of both anti-Epstein-Barr virus-IgG and IgM antibodies in patients (91.02% vs 82.11% in controls, p &lt; 0.001 and 14.1% vs 4.06% in controls, p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: EBV; MS; Reactivation; QPCR; ELISA.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200007

Evaluation of reagent strips for ascitic fluid leukocyte determination: is it a possible alternative for spontaneous bacterial peritonitis rapid diagnosis?
Provedor de dados: 55
Autores: Ribeiro,Tarsila C.R.; Kondo,Mario; Amaral,Ana Cristina C.; Parise,Edson Roberto; Bragagnolo Júnior,Maurício A.; Souza,Aécio Flávio Meirelles de.
In order to evaluate the accuracy of a urine reagent dipstick (Multistix 10SG®) to determine ascitic fluid leukocyte count, we prospectively studied 106 cirrhotic patients from April 2003 to December 2004, in two different centers (Federal University of São Paulo - UNIFESP-EPM and Federal University of Juiz de Fora - HU-UFJF) for the rapid bedside diagnosis of spontaneous bacterial peritonitis. The mean age 54 ± 12 years, there was a predominance of males (eighty-two patients, 77%), and alcohol was the most frequent etiology (43%). Forty-four percent of patients were classified as Child B and fifty-one as Child C (51%). Abdominal paracentesis was performed both in outpatient and inpatient settings and the Multistix 10SG® was tested. Eleven cases of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ascitic fluid; Rapid diagnosis; Dipstick; Bacterial peritonitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100017

Evaluation of resistance acquisition during tuberculosis treatment using whole genome sequencing
Provedor de dados: 55
Autores: Silva Feliciano,Cinara; Rodrigues Plaça,Jessica; Peronni,Kamila; Araújo Silva Jr,Wilson; Roberto Bollela,Valdes.
Abstract Tuberculosis (TB) is still considered a major global public health problem in the world and there is a concern about the worldwide increase of drug-resistance (DR). This paper describes the analysis of three Mycobacterium tuberculosis isolates from a single patient collected over a long treatment period of time. DR was initially investigated through phenotypic testing, followed by line probe assays (LPAs) and whole genome sequencing (WGS). It presents an intriguing situation where a multidrug-resistant (MDR-) TB case was diagnosed and treated based only on late phenotypic drug susceptibility testing of isolate 1. During the treatment, another two isolates were cultivated: isolate 2, nine months after starting MDR-TB treatment; and isolate 3,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Tuberculosis; Drug resistant tuberculosis; Drug susceptibility tests; Whole genome sequencing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300012

Evaluation of short-interfering RNAs treatment in experimental rabies due to wild-type virus
Provedor de dados: 55
Autores: Appolinario,Camila Michele; Allendorf,Susan Dora; Peres,Marina Gea; Fonseca,Clovis Reynaldo; Vicente,Acacia Ferreira; Antunes,João Marcelo Azevedo de Paula; Pantoja,José Carlos Figueiredo; Megid,Jane.
ABSTRACTWe have evaluated the efficacy of short-interfering RNAs targeting the nucleoprotein gene and also the brain immune response in treated and non-treated infected mice. Mice were inoculated with wild-type virus, classified as dog (hv2) or vampire bat (hv3) variants and both groups were treated or leaved as controls. No difference was observed in the lethality rate between treated and non-treated groups, although clinical evaluation of hv2 infected mice showed differences in the severity of clinical disease (p = 0.0006). Evaluation of brain immune response 5 days post-inoculation in treated hv2 group showed no difference among the analyzed genes, whereas after 10 days post-inoculation there was increased expression of 2',5'-oligoadenylate synthetase...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Dog virus; Bat virus; SiRNA.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500453

Evaluation of techniques for the diagnosis of Strongyloides stercoralis in human immunodeficiency virus (HIV) positive and HIV negative individuals in the city of Itajaí, Brazil
Provedor de dados: 55
Autores: Blatt,Jucelene Marchi; Cantos,Geny Aparecida.
Human immunodeficiency virus (HIV) and intestinal parasites are common in Brazil. Previous studies have shown that infection with Strongyloides stercoralis is frequently associated with HIV infection. Strongyloidiasis is difficult to diagnosis and stool examination with conventional techniques fails to detect the helminth larvae. We made a prospective study, to test the efficacy of the agar plate technique to detect S. stercoralis in 211 HIV-positive patients and 213 HIV-negative patients in the city of Itajaí, Brazil, between September 2001 and June 2002. The feces samples of these patients were processed and analyzed according to the following methods: Lutz, formalin ethyl acetate, Baermann, Harada-Mori and agar plate culture. HIV-positive patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Agar plate culture; HIV; Strongyloides stercoralis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600008

Evaluation of the accuracy of various phenotypic tests to detect oxacillin resistance in coagulase-negative staphylococci
Provedor de dados: 55
Autores: Perez,Leandro Reus Rodrigues; d'Azevedo,Pedro Alves.
In this study, we determined the accuracy of phenotypic tests (cefoxitin agar dilution, 30µg-cefoxitin and 1µg-oxacillin disks) to detect the oxacillin resistance/mecA gene among coagulase-negative staphylococci (CoNS) isolates. The presence of the mecA gene was detected by PCR technique (gold standard). A total of 176 CoNS isolates from blood of hospitalized patients were evaluated. Of these, 138 (78.4%) harbored the mecA gene. Using 30µg-cefoxitin and 1µg-oxacillin disks we obtained 100 and 98.3% accuracy, respectively. In addition, when cefoxitin was used as marker in an agar dilution method, the higher accuracy (99.4%) was established with 8mg cefoxitin per mL breakpoint. Thus, despite of the agar dilution method using cefoxitin as a marker not being...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oxacillin; Cefoxitin; CoNS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300009

Evaluation of the automated system Vitek2 for identification and antimicrobial susceptibility testing of Brazilian Gram-positive cocci strains
Provedor de dados: 55
Autores: d'Azevedo,Pedro Alves; Siquiera,Itacy; Gugel,Juliana; Antunes,Ana Lúcia Souza; Secchi,Carina; Pasternak,Jacyr; Martino,Marinês Dalla Vale.
Automated instruments offer many advantages for clinical laboratories. Nevertheless, they can have problems identifying and determining susceptibilities of some pathogens. Vitek® 2 (bioMérieux) is an automated system that was recently introduced to Brazil. We evaluated the performance of this equipment for Brazilian isolates that had been characterized using reference identification and antimicrobial susceptibility testing methods. Ninety-nine strains of Gram-positive cocci from a local reference center collection were analyzed, consisting of 50 coagulasenegative Staphylococcus (CoNS) and 49 Enterococcus and related species. Vitek® 2 correctly identified 79.8% (79/99) of the isolates. Oxacillin resistance was detected in 76% (19/25) of resistant S....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Automated system; Vitek2; Gram-positive cocci; Identification; Antimicrobial susceptibility testing.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200007

Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women
Provedor de dados: 55
Autores: Firmino,Alisson de Aquino; Martins,Adenilda Lima Lopes; Gois,Luana Leandro; Paixão,Taiane Silva; Batista,Everton da Silva; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios.
ABSTRACT  Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women.  Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendimento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected women reported any HTLV-1-associated diseases. All volunteers underwent gynecological examination to collect cervicovaginal fluid. Cytokine quantification was performed using the Cytometric Bead Array (CBA) Human Th1/Th2/Th17 kit....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; Inflammatory cytokines; Proviral load; Cervicovaginal cytopathology.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100027

Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
Provedor de dados: 55
Autores: Bahia,Fabianna; Pedroso,Célia; Netto,Eduardo Martins; Figueiredo,Ricardo; Pinto Neto,Lauro; Brites,Carlos.
We analyzed the first 96 patients tested for HIV resistance to antiretroviral therapy in three Brazilian states. The HIV-1 reverse transcriptase (RT) and protease (PR) were sequenced by using the ABI ViroSeq system. The drugs previously used for each patient were recorded and correlated with the mutations found in the samples. Viral load (VL) and CD4 count were also recorded. Only one patient had the wild type sequence. The most prevalent mutations were: 184V (59%), 41L (47.9%), 63P (53%), 215Y (50%), 36I (46%), 10I (35%), 67N (42%), 77I (37%), 90M (36%) and 210W (33%). A positive correlation between the number of previously used ARVs and the number of mutations was observed (p&lt;0.05). Associations between mutations and ARV drugs were identified at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Mutations; Resistance; Antiretrovirals.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400003

Evaluation of the incidence of occult bacteremia among children with fever of unknown origin
Provedor de dados: 55
Autores: Berezin,Eitan Naaman; Iazzetti,Marco Antonio.
We reviewed the incidence of occult bacteremia, to identify the most frequent etiological agents of bacteremias in otherwise healthy children from one month to 10 years old, who had fever of unknown origin attended at the emergency ward of an urban, university-affiliated pediatric referral center. This was a retrospective medical record review, evaluating children with fever. Data were collected from the initial visit, when blood cultures, hematological properties and hemosedimentation rates were examined. Fever was considered as the highest temperature assessed in the hospital or reported by the responsible adult. Occult bacteremia was discovered in 1.4% of the 1,051 children evaluated, and the most common etiologic agent was Streptococcus pneumoniae....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fever; Streptococcus pneumoniae; Occult bacteremia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600007

Evaluation of the prescription and use of antibiotics in Brazilian children
Provedor de dados: 55
Autores: Del Fiol,Fernando de Sá; Lopes,Luciane Cruz; Barberato-Filho,Silvio; Motta,Cristiane de Cássia Bergamaschi.
INTRODUCTION: Inappropriate use of antibiotics leads to increased levels of bacterial resistance making it difficult to treat upper respiratory tract infections. The appropriate use of these drugs has a fundamental role in controlling resistance and in success of treatment of childhood infections. Therefore, the aim of this study was to assess the prescription and use of antibiotics for Brazilian children. METHODS: The use of antibiotics in 160 children was monitored in two Primary Health Centers by questionnaires administered to parents and caregivers that assessed the social, demographic and clinical conditions of the children. Furthermore, the antibiotic use pattern was ascertained in these children and compared to the recommendations of the Brazilian...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotic Pediatrics Prescription.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300005

Evaluation of the presence of microorganisms in solid-organ preservation solution
Provedor de dados: 55
Autores: Mattana,André Marcelo Colvara; Marra,Alexandre Rodrigues; Machado,Antônia Maria de Oliveira; Lopes Filho,Gaspar de Jesus; Salzedas Netto,Alcides Augusto; Gonzalez,Adriano Miziara.
OBJECTIVE: To assess the presence of microorganism contamination in the preservation solution for transplant organs (kidney/pancreas). Method: Between August 2007 and March 2008, 136 samples of preservation solution were studied prior to graft implantation. Variables related to the donor and to the presence of microorganisms in the preservation solution of organs were evaluated, after which the contamination was evaluated in relation to the "recipient culture" variable. Univariate and multivariate statistical analyses were performed. RESULTS: The contamination rate of the preservation solution was 27.9%. Coagulase-negative Staphylococcus was the most frequently isolated microorganism. However, highly virulent agents, such as fungi and enterobacteria, were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Organ transplantation disease transmission; Infectious organ preservation solutions microbial viability.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600005

Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax
Provedor de dados: 55
Autores: Tarazona,Alonso Soto; Zerpa,Lely Solari; Mendoza Requena,Daniel; Llanos-Cuentas,Alejandro; Magill,Allan.
OBJECTIVE: To determine the sensitivity and specificity of the rapid diagnostic test OptiMAL® for diagnosis of Plasmodium vivax malaria. MATERIAL AND METHODS: We included all the patients who sought medical attention in the San Martin Pangoa Hospital, Junin, an area endemic for vivax malaria in Peru, between October and December 1998, who had fever during the previous 72 hours and who were older than 12 months. The gold standard for diagnosis was thick blood film microscopy. We determined the parasitemia rate for each of the positive slides. We calculated sensitivity, specificity, positive predictive value and negative predictive value of the test. RESULTS: We included 72 patients; 39 of them were positive for P. vivax by microscopic examination. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: OptiMAL; Malaria; Plasmodium vivax; Diagnosis; Dipstick.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200005

Evaluation of the role of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer of epithelial cells
Provedor de dados: 55
Autores: Ramsugit,Saiyur; Pillay,Balakrishna; Pillay,Manormoney.
Abstract This study was undertaken in order to assess the involvement of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer in the M. tuberculosis-epithelial cell interaction. A MTP-deficient strain of M. tuberculosis demonstrated a significant reduction of 69.39% (p = 0.047) and 56.20% (p = 0.033) in its ability to adhere to and invade A549 pulmonary epithelial cells, respectively, in comparison with the wild-type strain. Complementation of the MTP-deficient mutant restored its adhesion and invasion capacity back to the wild-type levels. Overall, it was found that similar concentrations of IL-1β, IL-4, IL-6, IL-8, G-CSF, IFN-γ, MCP-1, and TNF-α were induced in A549 cells infected with the MTP-proficient and MTP-deficient...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Curli pili; Adhesin; Invasin.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200160

Evaluation of the secretory immunoglobulin A levels in the colostrum and milk of mothers of term and pre-trerm newborns
Provedor de dados: 55
Autores: Araújo,Edílson D.; Gonçalves,Ana Katherine; Cornetta,Maria da Conceição; Cunha,Heleana; Cardoso,Maria L.; Morais,Sirlei Siani; Giraldo,Paulo C.
OBJECTIVE: To determine and to compare the levels of secretory immunoglobulin A in samples of colostrum and milk of mothers of term and preterm neonates. MATERIAL AND METHODS: The levels of secretory immunoglobulin A of 10 mothers of term neonates and 10 mothers of preterm neonates were determined from 5mL of colostrum or milk collected on the 1st, 4th, 10th and 15th days of the puerperal period, using the radial immunodifusion technique. We employed anamnesis, as well as physical and gynecological exams in women in the puerperal period. All the patients were attended at the Januário Cicco Maternity College. RESULTS: The secretory immunoglobulin A levels were significantly higher in the colostrum and milk of mothers of preterm neonates when compared with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Secretory immunoglobulin A; Milk; Neonates.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500002

Evaluation of the Susceptibility profiles, genetic similarity and presence of qnr gene in Escherichia coli resistant to ciprofloxacin isolated in Brazilian hospitals
Provedor de dados: 55
Autores: Pereira,Andrea S.; Andrade,Soraya S.; Monteiro,Jussimara; Sader,Helio S.; Pignatari,Antonio C.C.; Gales,Ana C.
Increasing quinolone resistance has been reported worldwide, mainly among clinical isolates of Escherichia coli. The objectives of this study were to determine the susceptibility profile, the genetic relatedness, and the prevalence of the qnr gene among ciprofloxacin-resistant Escherichia coli isolated from distinct Brazilian hospitals. A total of 144 ciprofloxacin-resistant Escherichia coli were isolated from 17 Brazilian hospitals between January/2002 and June/2003. The antimicrobial susceptibility testing was performed by microdilution according to NCCLS. The presence of the qnr gene was initially screened by colony blotting, and then confirmed by PCR followed by DNA sequencing. Ninety-five urinary ciprofloxacin-resistant Escherichia coli were further...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quinolone resistance; Escherichia coli; PFGE; Qnr.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100011

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma
Provedor de dados: 55
Autores: Petrilli,Antonio Sérgio; Cypriano,Monica; Dantas,Lenice Silva; Lee,Lúcia Martino; Luisi,Maria Flávio Augusto Vercillo; Silva,Katia Veronica Torres B.; Pereira,Carlos Alberto Pires.
BACKGROUND: The empirical use of antibiotic treatments is widely accepted as a means to treat cancer patients in chemotherapy who have fever and neutropenia. Intravenous monotherapy, with broad spectrum antibiotics, of patients with a high risk of complications is a possible alternative. METHODS: We conducted a prospective open-label, randomized study of patients with lymphoma or leukemia who had fever and neutropenia during chemotherapy. Patients received either monotherapy with ticarcillin/clavulanic acid (T) or ceftriaxone plus amikacin (C+A). RESULTS: Seventy patients who presented 136 episodes were evaluated, 68 in each arm of the study. The mean neutrophil counts at admission were 217cells/mm³ (T) and 201cells/mm³ (C+A). The mean duration of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fever; Neutropenia; Leukemia; Lymphoma; Ticarcillin; Ceftriaxone.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200003

Evaluation of urinalysis parameters to predict urinary-tract infection
Provedor de dados: 55
Autores: Santos,Juliana Conrad dos; Weber,Liliana Portal; Perez,Leandro Reus Rodrigues.
We evaluated the performance of automated-flow cytometry, urinalysis dipsticks and microscopic urine sediment analysis as predictors of urinary tract infection. Urine cultures were used as a reference method for comparison. Six-hundred-seventy-five urine samples from hospitalized and not hospitalized patients attended at Hospital Mãe de Deus, Porto Alegre, in south Brazil, were included in the study. Among the individual measures analyzed, intense bacteriuria in the microscopic analysis of urinary sediment gave an accuracy of 92.9%. A combination between intense bacteriuria (microscopic analysis) and &gt;20 leukocytes per µL of urine (flow cytometry) gave a higher accuracy (97.3%). We conclude that though it is laborious, microscopic urinalysis is a good...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urinary tract infection; Urinalysis; Flow cytometry.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500008

Evaluation of viral resistance to Reverse Transcriptase Inhibitors (RTI) in HIV-1-infected patients before and after 6 months of single or double antiretroviral therapy
Provedor de dados: 55
Autores: Brites,Carlos; Bahia,Fabianna; Gilbert,Mark; Pedroso,Célia; Badaró,Roberto.
We evaluated samples of peripheral blood mononuclear (PBMC) cells from 46 AIDS patients, before starting therapy with HIV-1 reverse transcriptase inhibitors (RTI), and after 6 months of drug use. PBMC were stored and tested by a Line Probe Assay (LiPA), in order to assess the frequency of RT mutations in this population. Six patients were taking AZT before initial blood collection (1 to 16 weeks of drug use) and 40 patients had no prior therapy. After baseline evaluation, 19 patients received AZT, 23 AZT plus DDI, 3 started AZT only with DDI added after 3 months, and 3 received a combination of AZT plus 3TC. Detection of at least one mutation was found in 33% (15/46) of patients at baseline, and 83% (38/46) had at least 1 mutation after 6 months of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Viral resistance; Brazil.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400003

Evaluation of Wondfo influenza A&amp;B fast test based on immunochromatography assay for rapid diagnosis of influenza A H1N1
Provedor de dados: 55
Autores: Peng,Yunping; Wu,Junlin; Liu,Xiaoyun; Wang,Jihua; Li,Wenmei.
Influenza viruses cause significant morbidity and mortality in both children and adults during local outbreaks or epidemics. Therefore, a rapid test for influenza A&amp;B would be useful. This study was conducted to evaluate the clinical performance of the Wondfo influenza A&amp;B test for rapid diagnosis of influenza A H1N1 Infection. The rapid testing assay could distinguish infection of influenza A and B virus. The reference viral strains were cultured in MDCK cells while TCID50 if the viruses were determined. The analytical sensitivity of the Wondfo kit was 100 TCID50/ml. The Wondfo kit did not show cross reactivity with other common viruses. 1928 suspected cases of influenza A (H1N1) virus infection were analyzed in the Wondfo influenza A&amp;B test...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Influenza A (H1N1); Influenza B; Fast test strip.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200019

Evolution of HTLV-1 proviral load in patients from Salvador, Brazil
Provedor de dados: 55
Autores: Olavarria,Viviana Nilla; Gomes,Alline do Nascimento; Kruschewsky,Ramon de Almeida; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios.
INTRODUCTION: Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. Objective: To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. METHODS: A group of 104 HTLV-1 infected patients, followed at the HTLV reference center in Salvador, Brazil, were included in the study (70 asymptomatic and 34 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients). HTLV-1 PVL was measured using real-time polymerase chain reaction (PCR) at baseline and again at another point, either &lt; 12 months, between 12-24 months, or &amp;gt; 24 months. RESULTS: HAM/TSP...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Asymptomatic; Evolution; HTLV-1; Proviral load; HAM/TSP.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400008

Expansion of gd T cells in patients infected with cutaneous leishmaniasis with and without glucantime therapy
Provedor de dados: 55
Autores: Darabi,Haideh; Abolhassani,Mohsen; Kariminia,Amina; Alimohammadian,Mohammad H.
The expansion of &lt;FONT FACE=Symbol&gt;gd &lt;/font&gt;T cells in patients with active cutaneous leishmaniasis, with or without glucantime therapy, was investigated. Twenty patients with local cutaneous leishmaniasis including glucantime-treated (n=10) and untreated (n=10) patients were selected. The controls were healthy individuals (n=10) living in endemic areas. Whole blood was obtained and the T cell subpopulations were analyzed by flow cytometry. Significantly more &lt;FONT FACE=Symbol&gt;gd&lt;/FONT&gt; CD3+ T cells were observed in untreated patients (15.9% ± 5.9), when compared with glucantime-treated patients (4.6% ± 1.4) and controls (5.3% ± 2.3). On the other hand, when the percentages of ab CD3+ T-cells were analyzed different results were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cutaneous leishmaniasis; Gamma-delta T cells; Glucatime therapy.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500007

Experimental infections with Paracoccidioides brasiliensis obtained from armadillos: comparison to clinical isolates
Provedor de dados: 55
Autores: Nishikaku,Angela Satie; Peraçoli,Maria Terezinha S.; Bagagli,Eduardo; Sugizaki,Maria Fátima; Sartori,Alexandrina.
Paracoccidioides brasiliensis causes paracoccidioidomycosis (PCM) that is one of the most prevalent systemic human mycoses in Latin America. Armadillos show a high incidence of PCM infection and could, therefore, be a natural reservoir for this fungus. In this study were compared the virulence profiles of isolates obtained from nine-banded armadillos (Dasypus novemcinctus) (PbT1 and PbT4) and isolates from PCM patients (Pb265 and Bt83). Pathogenicity was evaluated by fungal load and analysis of colony morphology. Immunity against the fungus was tested by delayed type hypersensitivity test (DTH) and antibody quantification by ELISA. The higher virulence of PbT1 and PbT4 was suggested by higher fungal load in spleen and lungs. Armadillo isolates and Bt83...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paracoccidioides brasiliensis; Armadillos; Infection; BALB/c mice.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100013

Experimental ventilator-associated pneumonia: distribution of lung infection and consequences for lung aeration
Provedor de dados: 55
Autores: Vieira,Silvia Regina Rios; Goldstein,Ivan; Lenaour,Gilles; Marquette,Charles-Hugo; Rouby,Jean-Jacques.
Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator associated pneumonia.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300007

Expression of class 5 antigens by meningococcal strains obtained from patients in Brazil and evaluation of two new monoclonal antibodies
Provedor de dados: 55
Autores: De Gaspari,Elizabeth N.; Zollinger,Wendell D.
Determining the profile of antigen expression among meningococci is important for epidemiologic surveillance and vaccine development. To this end, two new mouse monoclonal antibodies (MAbs) have been derived against Neisseria meningitidis proteins (class 5). The MAbs were reactive against outer membrane antigens and were bactericidal. Selected anti-class 5 MAbs [(5.1)-3E6-2; (5.3)-3BH4-C7; (5.4)-1BG11-C7; (5.5)-3DH-F5G9 also 5F1F4-T3(5.c)], and the two new monoclonal antibodies C14F10Br2 (5.8) and 7F11B5Br3 (5.9), were then tested against different meningococcal strains, (63 strains of serogroup A, 60 strains of serogroup C (from 1972 to 1974); and 136 strains of serogroup B (from 1992) meningococci). Our results demonstrated that the expression of class 5...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Monoclonal antibodies; Outer membrane protein; Flow cytometry.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300007

Expression of Hepatitis B virus surface antigen (HBsAg) from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection
Provedor de dados: 55
Autores: Araujo,Natalia M.; Vianna,Carlos O. A.; Moraes,Marcia T. B.; Gomes,Selma A.
The impact of hepatitis B virus (HBV) genotypes on the sensitivity of surface antigen (HBsAg) detection assays has been poorly investigated. Here, plasmids carrying consensus or variant coding sequences for HBV surface proteins from genotypes A, D and F, were constructed. HBsAg levels were evaluated in medium and extracts of transfected CHO cells by a commercial polyclonal-based assay. We show that HBsAg detection values of consensus forms from genotypes D and F were, respectively, 37% and 30% lower than those obtained by genotype A. However, the presence of two single variations, T143M in genotype A, and T125M in genotype D, produced a decrease of 44% and an increase of 34%, respectively, on HBsAg mean values in comparison with their consensus forms. In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Surface antigen; Amino acid variations; Transfection.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400005

Expression of immunohistochemical markers in patients with AIDS-related lymphoma
Provedor de dados: 55
Autores: Barreto,Luciana; Azambuja,Denize; Morais,José Carlos de.
AIDS-related lymphomas (ARL) present high biological heterogeneity. For better characterization of this type of lymphoma, the objectives of the present study were to evaluate the expression of immunohistochemical markers of cell differentiation (CD10, Bcl-6, MUM-1) and determine cell origin profile according to Hans' classification of diffuse large B-cell lymphoma in AIDS patients. This study included 72 consecutive patients with ARL diagnosed at the University Hospital, Universidade Federal do Rio de Janeiro (UFRJ) and at the Brazilian Instituto Nacional de Câncer (INCA) from 2000 to 2006. The morphologic distribution of the lymphomas was the following: 61% were diffuse large B-cell lymphomas (DLBCLs), 15% were Burkitt's lymphomas, 13% were plasmablastic...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: AIDS related-lymphoma; AIDS.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100013

Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella entérica strains with and without quinolone resistance-determining regions gyrA gene mutations
Provedor de dados: 55
Autores: Ferrari,Rafaela Gomes; Galiana,Antonio; Cremades,Rosa; Rodríguez,Juan Carlos; Magnani,Marciane; Tognim,Maria Cristina Bronharo; Oliveira,Tereza C.R.M.; Royo,Gloria.
Several studies have been conducted in recent years to elucidate the structure, function and significance of AcrB, MarA, SoxS and RamA in Salmonella enterica. In this study, the relative quantification of acrB, soxS, marA and ramA genes expression was evaluated in 14 strains of S. enterica, with or without accompanying mutations in the quinolone resistance-determining regions of the gyrA gene, that were exposed to ciprofloxacin during the exponential growth phase. The presence of ciprofloxacin during the log phase of bacterial growth activated the genes marA, soxS, ramA and acrB in all S. enterica strains analyzed in this study. The highest expression levels for acrB were observed in strains with gyrA mutation, and marA showed the highest expression in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella sp.; Fluoroquinolone; Efflux pump; Antibiotic resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200002

Extended spectrum β-lactamase producers among nosocomial Enterobacteriaceae in Latin America
Provedor de dados: 55
Autores: Guzmán-Blanco,Manuel; Labarca,Jaime A.; Villegas,Maria Virginia; Gotuzzo,Eduardo.
To review the epidemiology of nosocomial extended spectrum β-lactamase-producing Enterobacteriaceae in Latin America, a systematic search of the biomedical literature (PubMed) was performed for articles published since 2005. Rates of nosocomial infections caused by extended spectrum β-lactamase-producing Enterobacteriaceae in Latin America have increased since 2005. Up to 32% of Escherichia coli and up to 58% of Klebsiella pneumoniae isolates are extended spectrum β-lactamase-positive, rates that are higher than in other world regions. From a region-wide perspective, 11-25% of E. coli isolates and 45-53% of K. pneumoniae isolates were nonsusceptible to third-generation cephalosporins. At the country level, there was a wide range in Enterobacteriaceae...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Escherichia coli; Klebsiella; Latin America; Bacterial resistance.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400421

Extended treatment with interferon and ribavirin in a hemodialysis patient with chronic hepatitis C
Provedor de dados: 55
Autores: Vigani,Aline Gonzalez; Pavan,Maria HP; Tozzo,Raquel; Gonçales,Eduardo SL; Lazarini,Maria SK; Oliveira,Alexandre Macedo de; Gonçales Jr,Fernando L.
Hemodialysis patient with chronic HCV infection,who was started on monotherapy with interferon.Qualitative HCV RNA remained positive at 12 weeks of treatment; ribavirin was associated. HCV RNA was negative at week 24 and treatment was extended to 72 weeks. HCV RNA negative six months after treatment.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hepatitis C virus; Hemodialysis; Treatment; Interferon; Ribavirin.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200016

Extensive variation in drug-resistance mutational profile of Brazilian patients failing antiretroviral therapy in five large Brazilian cities
Provedor de dados: 55
Autores: Brites,Carlos; Pinto-Neto,Lauro; Medeiros,Melissa; Nunes,Estevão; Sprinz,Eduardo; Carvalho,Mariana.
Abstract  Background Development of drug-resistance mutations is the main cause of failure in antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients failing antiretroviral therapy.  Objectives To define the HIV mutational profile associated with drug resistance in Brazilian patients from 5 large cities, after first, second or further failures to antiretroviral therapy.  Methods We reviewed genotyping results of 1520 patients failing therapy in five Brazilian cities. Frequency of mutations, mean number of active drugs, viral susceptibility to each antiretrovirals drug, and regional differences were assessed.  Results Mean time of antiretrovirals use was 22.7 ± 41.1 months. Mean pre-genotyping viral load was 4.2 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Resistance; Brazil; Mutations.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400323

Extensively drug-resistant tuberculosis: a case report and literature review
Provedor de dados: 55
Autores: Araújo-Filho,João Alves de; Vasconcelos-Jr,Arioldo Carvalho; Sousa,Eduardo Martins de; Silveira,Colombina da; Ribeiro,Elisangela; Kipnis,André; Junqueira-Kipnis,Ana Paula.
Extensively drug-resistant tuberculosis (XDR-TB) is an emerging health problem that threatens tuberculosis (TB) control worldwide, since suitable treatment for this disease has not yet been found. We report a case of secondary pulmonary XDR-TB in a 54-year-old, HIV-negative male from Goiânia, Brazil. The patient had long-standing pulmonary tuberculosis (nine years) with extensive bilateral lung damage and had been treated with multiple antituberculosis drugs (self-administered) before XDR-TB diagnosis. The strain of Mycobacterium tuberculosis was resistant to R- rifampicin, H-isoniazid, E-ethambutol, Eto-ethionamide, Ofx-ofloxacin, and Am-amikacin. This patient died with multiple organ failure due to sepsis secondary to bacterial pneumonia.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extensively drug-resistant tuberculosis; XDR-TB; Tuberculosis; Mycobacterium tuberculosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500019

Extrahepatic manifestations of chronic hepatitis C infection: a consecutive study in Brazilian patients
Provedor de dados: 55
Autores: Tengan,Fátima M.; Levy-Neto,Mauricio; Miziara,Ivan D.; Dantas,Bianca P.; Maragno,Luciana.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200203

Extra-pulmonary Pneumocystis jiroveciinfection: a case report
Provedor de dados: 55
Autores: Karam,Mehrdad Bakhshayesh; Mosadegh,Leila.
In physical examination abdominal tenderness, gate disturbance and penile herpetic lesions were detected. Decreased disc height at T11-T12 level was detected in chest X-ray. Abdominal sonography and CT scan revealed hypo dense lesions in Lt left Lobe of liver and multiple hypo dense splenic and pancreatic lesions, ascitis, Lt left sided pleural effusion, thickening of jejuneal mucosa and edema of bowel wall. Vertebral body lesion and paravertebral abscess, bony calvarial involvement and adjacent extra axial brain lesion were observed in imaging were other findings. RNA analysis for HIV was positive. Vertebral lesion biopsy and aspiration of splenic lesion were performed and pathology revealed Pneumocystis jirovecii suggestive of extra pulmonary...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Extrapulmonary; HIV; Pneumocystis Jirovecia.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600681

Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS
Provedor de dados: 55
Autores: Azevedo,Larissa Negromonte; Ximenes,Ricardo Arraes de Alencar; Monteiro,Polyana; Montarroyos,Ulisses Ramos; Miranda-Filho,Demócrito de Barros.
ABSTRACT Antiretroviral therapy (ART) has modified the outcome of patients with HIV infection, providing virological control and reducing mortality. However, there are several reasons as to why patients may discontinue their antiretroviral therapy, with adverse events being one of the main reasons reported in the literature. This is a case-control nested in a cohort of people living with HIV/AIDS, conducted to identify the incidence of ART modification due to adverse events and the associated factors, in two referral services in Recife, Brazil, between 2011 and 2014. Of the modifications occurred in the first year of ART, 25.7% were driven by adverse events. The median time elapsed between initiating ART and the first modification due to adverse events was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Zidovudine; Tenofovir; Efavirenz; Adverse events.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100065

Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir
Provedor de dados: 55
Autores: Machado,Daisy Maria; Gouvêa,Aída de Fátima Barbosa; Cardoso,Maria Regina; Beltrão,Suênia Vasconcelos; Cunegundes,Kelly Simone; Bononi,Fabiana; Almeida,Fernanda; Cavalheiro,Kaline; Angelis,Daniela Souza Araújo de; Succi,Regina Célia de Menezes.
This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to &gt; 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Children; HAART; Lopinavir/ritonavir.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100006

Factors associated with epidemic multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions
Provedor de dados: 55
Autores: Gomes,Marisa Zenaide Ribeiro; Oliveira,Raquel Vasconcellos C. de; Machado,Carolina Romero; Conceição,Magda de Souza da; Souza,Cristina Vieira de; Lourenço,Maria Cristina da Silva; Asensi,Marise Dutra.
INTRODUCTION: Infections caused by multiresistant Pseudomonas aeruginosa (MR-PA) have been associated with persistent infections and high mortality in acquired immunodeficiency syndrome (AIDS) patients. Therefore, understanding the predisposing factors for infection/colonization by this agent is critical for controlling outbreaks caused by MR-PA in settings with AIDS patients. OBJECTIVEAND METHODS: To analyze the presence of factors associated with the acquisition of an epidemic MR-PA strain in a hospital with AIDS-predominant admission. A case-control study was carried out in which cases and controls were gathered from a prospective cohort of all hospitalized patients in an infectious disease hospital during a five-year study period. RESULTS: Multivariate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Risk factors; Disease outbreaks; Molecular epidemiology; Acquired immunodeficiency syndrome.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300001

Factors associated with inspiratory muscle weakness in patients with HIV-1
Provedor de dados: 55
Autores: Jerônimo,Fabiana S.; Alves,Giovanni N.; Cipriano Jr.,Gerson; Vieira,Paulo J.C.; Chiappa,Adriana M. Güntzel; Chiappa,Gaspar R.
Background:the impact of human immunodeﬁciency virus type 1 (HIV-1) on lung function is well known and associated with a reduction in pulmonary ventilation. Moreover, the use of highly active antiretroviral therapy has been associated with mitochondrial dysfunction and decreased muscle strength. However, there is scarce information about the factors associated with inspiratory muscle weakness in these patients.Objective:the purpose of the present study was to investigate the factors associated with inspiratory muscle weakness in patients with HIV-1.Methods:two-hundred ﬁfty seven patients with HIV-1 were screened and categorized into two groups: (1) IMW+ (n= 142) and (2) IMW-(n= 115). Lung function (FEV1, FVC and FEV1 /FVC), maximum inspiratory pressure,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diaphragm muscle Inﬂammatory response Lung function; Exercise tolerance; Highly active antiretroviral therapy Inspiratory muscle.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100001

Factors associated with mortality in HIV patients failing antiretroviral therapy, in Salvador, Brazil
Provedor de dados: 55
Autores: Haguihara,Tatiana; Silva,Márcio da Oliveira; Rebouças,Monaliza Cardozo; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT Highly active antiretroviral therapy (HAART) has significantly improved survival of people living with HIV/Aids (PLWHA). However, poor treatment adherence to HAART and other problems, still cause therapy failure and contribute to increased morbidity and mortality of PLWHA. In this retrospective cohort study (2013-2015), we sought to evaluate the factors associated with mortality of PLWHA failing HAART in 2013, who were receiving care at a reference center for sexually transmitted diseases (STD) and HIV/AIDS. A total of 165 individuals over 18 years of age who were failing antiretroviral therapy were evaluated. In two-year follow-up, 19 (11.5%) deaths were documented. There were a significant association between mortality and report of illicit drug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Virologic failure; Mortality; HIV.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300160

Factors associated with pain in individuals infected by human T-cell lymphotropic virus type 1 (HTLV-1)
Provedor de dados: 55
Autores: Santos,Dislene N. dos; Santos,Kionna O.B.; Paixão,Alaí B.; Andrade,Rosana Cristina P. de; Costa,Davi T.; S-Martin,Daniel L.; Sá,Katia N.; Baptista,Abrahão F.
Abstract  Introduction Despite the high prevalence of chronic pain in individuals infected with HTLV-1, predictive and protective factors for its development are still unclear.  Objective To identify factors associated with chronic pain in individuals with HTLV-1.  Methods This cross-sectional study was conducted in a reference center for treatment of patients infected with HTLV-1 in Salvador, Bahia, Brazil. The study included individuals infected with HTLV-1, over 18 years, and excluded those with difficulty to respond the pain protocol. Data on sociodemographic, health behavior, and clinical characteristics were collected in a standardized way. The prevalence ratio (PR) of pain is described, as well as the factors independently associated with the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human T-cell lymphotropic virus type I (HTLV-1); Tropical spastic paraparesis; Retroviridae infections; Chronic pain.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200133

Factors associated with vaccination against hepatitis B in adolescents and young adults from an urban settlement
Provedor de dados: 55
Autores: Guimarães,Rafael Alves; Matos,Marcos André DE.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300332

Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection
Provedor de dados: 55
Autores: Prata-Rocha,Mariana Lima; Gontijo-Filho,Paulo Pinto; Melo,Geraldo Batista de.
Multidrug-resistant (MDR) Acinetobacter baumannii (Acb) is a rapidly emerging pathogen in healthcare settings. The aim of this study was to evaluate the predictors of poor outcome in patients with MDR Acb. This is the first report documenting factors influencing survival in patients with MDR Acb in this tertiary hospital. This study is a prospective of the hospital epidemiology database. A total of 73 patients with 84 Acb isolates were obtained between August 2009 and October 2010 in this hospital. In the present study, the 30-day mortality rate was 39.7%. Of 84 Acb isolates, 50 (59%) were MDR, nine (11%) were pan-resistant, and 25 (30%) were non-MDR. The non-MDR isolates were used as the control group. The factors significantly associated with multidrug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multidrug-resistant; Acinetobacter baumannii; Gram-negative bacteria.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300004

Factors influencing the early mortality in haematological malignancy patients with nosocomial Gram negative bacilli bacteraemia: a retrospective analysis of 154 cases
Provedor de dados: 55
Autores: Metan,Gökhan; Demiraslan,Hayati; Kaynar,Leyla Gül; Zararsız,Gökmen; Alp,Emine; Eser,Bülent.
BACKGROUND: The aim of this study is to assess the factors influencing the early mortality (7- day after index blood culture) in haematological malignancy patients with Gram negative bacilli (GNB) bacteraemia. METHODS: Infection control committee records were reviewed to identify the cases between March 2006 and June 2011. Only one bacteraemic episode per patient was included in the study. RESULTS: A total of 154 patients with GNB bacteraemia were identified. The early mortality rate was 19.5% (30 out of 154). Blood cultures revealed Enterobacteriacea in 120 patients (Escherichia coli; 86, Klebsiella spp.; 28, Enterobacter cloacea; 6) and glucose non-fermenting GNB in 34 patients (Pseudomonas aeruginosa; 15, Acinetobacter baumannii; 11, Stenotrophomonas...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haematological malignancy; Bacteraemia; Gram negative bacilli; Mortality; Extended-spectrum beta-lactamase; Intensive care unit; Multidrug resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200005

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital
Provedor de dados: 55
Autores: Carvalho,Bráulio Matias de; Monteiro,André Jalles; Pires Neto,Roberto da Justa; Grangeiro,Thalles Barbosa; Frota,Cristiane Cunha.
Infection with both Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis is currently the world's leading cause of death due to infectious agents. We evaluated factors related to the development of tuberculosis (TB) in HIV-infected patients who were being treated at an infectious diseases hospital in Fortaleza, Ceará, Brazil. From January 2004 to December 2005, we made an epidemiological study through the analysis of the medical records of 171 patients, who were diagnosed as having both HIV and tuberculosis. Among these co-infected patients, most (81%, p=0.0006) were male. Co-infection was more frequent (87.8%) among patients over 40 years of age and those with lower educational levels (less than eight years of schooling). Forty-one percent of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Mycobacterium tuberculosis; HIV/TB co-infection; Risk factors; AIDS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400005

False-positive results in screening for metallo-β-lactamase are observed in isolates of Acinetobacter baumannii due to production of oxacilinases
Provedor de dados: 55
Autores: Martins,Andreza F.; Borges,Aline; Pagano,Mariana; Dalla-Costa,Libera Maria; Barth,Afonso L.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400021

Fatal adenoviral necrotizing bronchiolitis case in a post-cardiac surgery intensive care unit
Provedor de dados: 55
Autores: Castelli,Jussara Bianchi; Siciliano,Rinaldo F; Vieira,Ricardo D; Aiello,Vera D; Strabelli,Tânia MV.
We report a case of a 67 year-old-male patient admitted to the intensive care unit in the post-coronary bypass surgery period who presented cardiogenic shock, acute renal failure and three episodes of sepsis, the latter with pulmonary distress at the 30th post-operative day. The patient expired within five days in spite of treatment with vancomycin, imipenem, colistimethate and amphotericin B. At autopsy severe adenovirus pneumonia was found. Viral pulmonary infections following cardiovascular surgery are uncommon. We highlight the importance of etiological diagnosis to a correct treatment approach.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adenovirus infections; Human; Intensive care units; Bronchiolitis; Viral; Thoracic surgery.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300018

Fatal bacteremia due to Anaerobiospirillum succiniciproducens: first description in Brazil
Provedor de dados: 55
Autores: Secchi,Carina; Cantarelli,Vlademir Vicente; Pereira,Fabiana de Souza; Wolf,Hilda Helena Chaer; Brodt,Teresa Cristina Zenobini; Amaro,Maria Cristina O.; Inamine,Éverton.
Anaerobiospirillum succiniciproducens is an anaerobic, Gram-negative, spiral shaped bacteria, which is motile by means of bipolar tuffs of flagella. This organism appears to be a rare cause of bacteremia in humans, and it usually affects patients submitted to immunosuppressive therapy. Anaerobiospirillum succiniciproducens resembles Campylobacter spp. in Gram-stained preparations, however, it is considered resistant to most antimicrobial drugs that are used to treat Campylobacter infections. We observed Gram-negative, spiral shaped bacteria in Gram-stained preparations from blood culture flasks. Growth occurred only under anaerobic incubation, and identification to the species level was achieved by PCR amplification of the 16S rRNA gene, followed by direct...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Bacteremia; Anaerobiospirillum spp.; Anaerobiospirillum succiniciproducens.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200008

Fatal case of bacteremia caused by an atypical strain of Corynebacterium mucifaciens
Provedor de dados: 55
Autores: Cantarelli,Vlademir Vicente; Brodt,Teresa Cristina. Z.; Secchi,Carina; Inamine,Everton; Pereira,Fabiana de Souza; Pilger,Diogo Andre.
Corynebacterium species have often been considered normal skin flora or contaminants; however, in recent years they have been increasingly implicated in serious infections. Moreover, many new species have been discovered and old species renamed, especially after molecular biology techniques were introduced. Corynebacterium mucifaciens is mainly isolated from blood and from other normally-sterile body fluids; it forms slightly yellow, mucoid colonies on blood agar. We report a fatal case of bacteremia due to an atypical strain of C. mucifaciens. This strain had atypical colony morphology; analysis of the 16S rRNA gene was used to define the species.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Bacteremia; Blood infection; Corynebacterium; Corynebacterium mucifaciens.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600013

Fatal case of donor-derived colistin-resistant carbapenemase-producing Klebsiella pneumoniae transmission in cardiac transplantation
Provedor de dados: 55
Autores: Galvão,Lisia Miglioli; Oliveira,Anna Paula Romero de; Ibanês,Aline Santos; Monteiro,Jussimara; Inoue,Fernanda; Dantas,Daniel Chagas; Sanchez,Flavio; Santos,Daniel Wagner; Abboud,Cely Saad.
ABSTRACT Herein we report a fatal case of donor-derived transmission of XDR-resistant carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) in cardiac transplantation. A 59-year-old male patient with non-obstructive hypertrophic cardiomyopathy underwent heart transplantation. On day 5 post-operation, blood cultures from the donor were positive for colistin-resistant carbapenemase-producing K. pneumoniae (ColR KPC-Kp) susceptible only to amikacin. Recipient blood cultures were also positive for ColR KPC-Kp with the same sensitivity profile as the donor isolate with an identical PFGE pattern. The patient was treated with double-carbapenems and amikacin. The patient evolved to pericarditis, osteomyelitis, and pulmonary necrosis, all fragment cultures...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cardiac transplantation; Klebsiella pneumoniae; Donor-derived infection; Carbapenem-resistant.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300235

Fatal disseminated mucormycosis in a patient with mantle cell non-hodgkin's lymphoma: an autopsy case
Provedor de dados: 55
Autores: Alacacioglu,Inci; Kargi,Aydanur; Ozcan,Mehmet Ali; Piskin,Ozden; Solak,Cilem; Secil,Mustafa; Unlu,Mehtat; Demirkan,Fatih; Ozsan,Guner Hayri; Undar,Bulent.
A patient with mantle cell non-Hodgkin's lymphoma presented herself with fever, nausea, right upper quadrant pain on the 7th day of R-CHOP chemotherapy. After hospitalization with the suspicion of acute cholecystitis, she received antibiotherapy with G-CSF because of emerging neutropenia at the 10th day of chemotherapy. Abdominal computed tomography revealed small infarcts in the spleen and kidneys. The echymotic lesion which developed on her right lateral malleolus, became bullous in the following days and treated as ecthyma gangrenosum. Altough the patient was afebrile with a normal neutrophil count on the third day of antibiotherapy, she developed acute renal failure and deteriorated rapidly. The patient underwent hemodialysis but expired on the 10th...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mucormycosis; Lymphoma; Autopsy.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300017

Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60)
Provedor de dados: 55
Autores: Andrade,Claudia Ferreira de; Cunha,Denise Cotrim da; Cavalcanti,Veronica; Filippis,Ivano de.
Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries. This is the first report of a fatal meningitis case caused by a cc60 clonal complex meningococcus in Brazil. Despite the immune-compromised state of the patient, the fatal outcome here described shows the potential pathogenic behavior of strains belonging to this clonal complex and how compromised hosts can be susceptible to meningococcal infections even if the strain is not particularly invasive.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meningitis; Meningococcal meningococcal infections Neisseria meningitidis serogroup C.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200017

Fatal Strongyloides stercoralis hyper-infection in a patient with multiple myeloma
Provedor de dados: 55
Autores: Yassin,Mohamed A; El Omri,Halima; Al-Hijji,Ibrahim; Taha,Ruba; Hassan,Reham; Aboudi,Kamal Al; El-Ayoubi,Hanadi.
Strongyloides stercoralis (S.S.) is a human intestinal parasite, which may lead to complicated strongyloidiasis. We report a case of disseminated strongyloidiasis following the treatment of myeloma. The patient developed skin lesions, respiratory distress, aseptic meningitis and bacterial and fungal sepsis. The diagnosis of strongyloidiasis was established through endotracheal tube secretions. Despite the treatment with Ivermectin and Albendazole, the outcome was fatal. The value of screening for strongyloidiasis is unclear but may be of benefit in patients with hematological malignancies from high endemic areas
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acute respiratory failure; Disseminated strongyloidiasis; Myeloma; Steroids.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500019

Fecal leukocyte in the diagnosis of ulcerative colitis
Provedor de dados: 55
Autores: Saraya,Takeshi; Suzuki,Tomokazu; Goto,Hajime.
Tipo: Info:eu-repo/semantics/report
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200225

Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance
Provedor de dados: 55
Autores: Soares,Killarney Ataide; Urdapilleta,Ada Amália Ayala; Santos,Gilcilene Maria dos; Carneiro,Andréa Lisboa; Gomes,Ciro Martins; Roselino,Ana Maria; Sampaio,Raimunda Nonata Ribeiro.
Background: Several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmaniaparasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is similar to that in which they cause infections in hosts.Objective: We attempted to validate a Leishmania mexicanaELISA exo-Ag for ATL diagnosis in Midwestern Brazil.Methods: A total of 281 patients were included in the study. We analysed pre-treatment blood from 98 ATL patients; out of those, 85.7% and 14.3% had cutaneous and mucosal forms,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diagnostics; Disease control; Infectious disease; Leishmaniasis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300302

FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis
Provedor de dados: 55
Autores: Domingues,Renan Barros; Santos,Márcio Vega dos; Leite,Fernando Brunale Vilela de Moura; Senne,Carlos.
ABSTRACT The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Therefore, other methods for rapid and accurate diagnosis of central nervous system infections are required. FilmArray meningitis/encephalitis (ME) panel is a PCR multiplex for simultaneous and rapid identification of 14 pathogens, including 6 bacteria, 7 viruses, and Cryptococcus. We evaluated 436 CSF samples submitted to FilmArray ME Panel. Among them, 25 cases were positive for bacteria, being Streptococcus pneumonia the most frequent (48 %). Among positive cases for bacteria, 60 % were positive only...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Meningitis; FilmArray Meningitis/Encephalitis; Cerebrospinal fluid; Polymerase chain reaction.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600468

First case of Furuncular Myiasis due to Cordylobia anthropophaga in a Latin American resident returning from Central African Republic
Provedor de dados: 55
Autores: Suárez,Jóse A.; Ying,Argentina; Orillac,Luis A.; Cedeño,Israel; Sosa,Néstor.
ABSTRACT Myiasis is a temporary infection of the skin or other organs with fly larvae.1 The larvae develop into boil-like lesions. Creeping sensations and pain are usually described by patients. Following the maturation of the larvae, spontaneous exiting and healing is experienced. Herein we present a case of a traveler returning from Central African Republic. She does not recall insect bites. She never took off her clothing for recreational bathing, nor did she visit any rural areas. The lesions appeared on unexposed skin. The specific diagnosis was performed by morphologic characterization of the larvae, resulting in Cordylobia anthropophaga, the dominant form of myiasis in Africa. To our knowledge, this is the first reported case of C. anthropophaga in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cordylobia anthropophaga; Furuncular myiasis; Tumbu-fly.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100070

First case of infection by metallo-β-lactamase-producing Pseudomonas aeruginosa in Mato Grosso do Sul, Brazil
Provedor de dados: 55
Autores: Ferreira,Kalinca Miranda; Rodrigues,Ana Claudia de Souza; Watanabe,Ana Carolina; Ferreira,Yanara Miranda; Chang,Marilene Rodrigues.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300359

First case of Nocardia nova spinal abscess in an immunocompetent patient
Provedor de dados: 55
Autores: Hong,Seung Bok; Han,Kyudong; Son,Bo Ra; Shin,Kyeong Seob; Rim,Byeong Cheol.
Nocardia are a group of aerobic actinomycetes that are filamentous gram-positive, weakly acid-fast, and cause opportunistic infection in immunocompromised patients. Primary Nocardia infection mostly involves lung, skin and less commonly, the central nervous system (CNS). Among Nocardia CNS infections, spinal infection is extremely rare. We describe the first case of a spinal abscess caused by Nocardia nova in an immunocompetent patient who experienced a penetrating facial injury six months earlier. Nocardia species were isolated from intradural spinal abscesses and identified by 16S rRNA, hsp65 and secA1 sequence analyses. Surgical excision and treatment with amikacin, cefotaxime, and oral erythromycin was successful.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nocardia Abscess Spine RNA; Ribosomal; 16S.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200017

First characterization of a Providencia stuartii clinical isolate from a Tunisian intensive care unit coproducing VEB-1-a, OXA-2, qnrA6 and aac(6')-Ib-cr determinants
Provedor de dados: 55
Autores: Mahrouki,Sihem; Chihi,Hela; Bourouis,Amel; Moussa,Mohamed Ben; Belhadj,Omrane.
A clinical Providencia stuartii isolate SM662 was recovered from a patient hospitalized in the intensive care unit at the Military hospital, Tunisia. This isolate was resistant to penicillins, cephalosporins, aminoglycosides and fluoroquinolones. A marked in vitro synergy between ceftazidime or cefotaxime and amoxicillin-clavulanic acid on Mueller-Hinton agar plates suggested the presence of an extended-spectrum-β-lactamase. In addition, an unusual synergy was found between cefepime or aztreonam, and cefoxitin or imipenem on a double disk synergy test suggesting a VEB-type extended-spectrum-β-lactamase. The characterization of β-lactamases and associated resistance genes was performed by isoelectric focusing, polymerase chain reaction and nucleotide...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: ESBL Providencia stuartii; QnrA6; Aac(6')-Ib-cr.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200211

First diagnostic cases of human babesiosis in Montenegro
Provedor de dados: 55
Autores: Andrić,Bogdanka; Golubović,Mileta; Terzic,Dragica; Dupanovic,Brankica; Icevic,Milos.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500022

First isolation of enterovirus 71 (EV-71) from Northern Brazil
Provedor de dados: 55
Autores: Lamarão,Leticia Martins; Maciel,Ana Maria T. R.; Gomes,Maria de Lourdes Contente.
Enterovirus 71 (EV-71) has been associated to cases of neurological disease in many countries including Brazil. This virus has now been reported from three of the five Brazilian regions. Our study relates the findings concerning to the first isolate of this virus in Northern region of Brazil. A 15-month old female patient, from the rural zone of the municipality of Santana do Araguaia in southern Pará state was admitted at the hospital with acute, flaccid, asymmetric and ascending motor deficiency, located in the right lower limb. Stools samples from this child were inoculated in RD cells and was isolated an EV-71. We plan to sequence our strain and compare it to other isolates in Brazil. Differences at the molecular level can explain why EV-71 strains...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Enterovirus-71; Neurological disease.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400009

First report of a NDM-producing Providencia rettgeri strain in the state of São Paulo
Provedor de dados: 55
Autores: Carmo Junior,Nelson Vieira do; Ferreira Filho,Heli; Costa,Durval Alex Gomes e; Calvalcante,Adilson Joaquim Westheimer; Garcia,Doroti de Oliveira; Furtado,Juvencio José Duailib.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600675

First report of submandibular and parotid abscess due to Nocardia asteroides
Provedor de dados: 55
Autores: Chawla,Kiran; Mukhopadhayay,Chiranjay; Shetty,Prashanth V.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500021

First reported case of infective endocarditis caused by community-acquired methicillin-resistant Staphylococcus aureus not associated with healthcare contact in Brazil
Provedor de dados: 55
Autores: Fortes,Claudio Querido; Espanha,Claudia Adelino; Bustorff,Flavio Pedreira; Zappa,Bruno Cordeiro; Ferreira,Adriana Lucia Pires; Moreira,Regina Barbosa; Pereira,Nelson Gonçalves; Fowler Jr.,Vance G.; Deshmukh,Hitesh.
We report here the first case of endocarditis due to CA-MRSA not associated with healthcare contact in Brazil in Brazil. A previously healthy patient presented with history of endocarditis following a traumatic wound infection. Patient had multiple positive blood cultures within 72 h of admission and met modified Duke's criterion for infective endocarditis. The isolate was typed as Staphylococcal cassette chromosome (SCC) mec type IV and was positive for presence of Panton-Valentine leukocidin (PVL). Increased incidence of CA-MRSA endocarditis is a challenge for the internist to choose the best empirical therapy. Several authors have suggested an empirical therapy with both a beta-lactam and an anti-MRSA agent for serious S. aureus infections. Our patient...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infective endocarditis; CA-MRSA; Brazil; PVL.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600020

First reported case of pneumonia caused by Cedecea lapagei in America
Provedor de dados: 55
Autores: Lopez,Luis Antonio Sanchez; Ibarra,Bárbara Saenz; Garza,Jess Alberto Cárdenas de la; Rada,Felipe de Jesus Martin Perez; Nuñez,Ana Isabel Sepúlveda; López,María Guadalupe Rodríguez.
Cedecea represents a genus in the Enterobacteriaceae family that has been rarely associated with human infection. The clinical relevance of Cedecea lapagei has yet to be elucidated. This is the first reported case of pneumonia due to C. lapagei in a patient with acute promyelocytic leukemia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pneumonia; Cedecea lapagei; Acute promyelocytic leukemia.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500023

First serological evidence of hantavirus infection in humans from the Orinoquia region of Colombia☆
Provedor de dados: 55
Autores: Sánchez,Liliana; Mattar,Salim; Rodriguez,Derly; Tique,Vaneza; Rodríguez,Islay.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500507

First survey for detecting the presence of human herpesvirus 8 infection (HHV-8) in Maputo, Mozambique
Provedor de dados: 55
Autores: Caterino-de-Araujo,Adele; Manuel,Rolanda Carmen Rafael; Bianco,Rosana Del; Santos-Fortuna,Elizabeth; Magri,Mariana Cavalheiro; Silva,Joyce Matie Kinoshita; Bastos,Rui.
Human herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma (KS), is endemic in parts of the sub-Saharan, and KS has increased concomitantly with the HIV/AIDS epidemic. In Mozambique (MZ), no data concerning HHV-8 infection was available, thus the main of this work was to investigate, for the first time, the presence of HHV-8 infection in Maputo, MZ. Latent and lytic HHV-8-specific antibodies were assessed in blood samples from 189 individuals from the Central Hospital of Maputo, MZ, using "in-house" immunofluorescence assays conducted in São Paulo, Brazil. The results obtained were analyzed according to socio-demographic and clinical variables using the Chi-square test and logistic regression. An HHV-8 seropositivity of 1.8% and 9.7% was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human herpesvirus 8 (HHV-8); Serology; Mozambique; Frequency; Kaposi's sarcoma.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300008

Five years of a special approach to medical communication: The Brazilian Journal of Infectious Diseases
Provedor de dados: 55
Autores: Badaró,Roberto; Jones,Thomas C.
Tipo: Info:eu-repo/semantics/other
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600012

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections
Provedor de dados: 55
Autores: Schiave,Letícia Aparecida; Nascimento,Erika; Vilar,Fernando Crivelenti; de Haes,Tissiana Marques; Takayanagui,Osvaldo Massaiti; Gaitani,Cristiane Masetto de; Martinez,Roberto.
ABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection criterion was treatment with fluconazole, which was performed with a generic or similar form of the drug. Fluconazole level was determined by high performance liquid chromatography and the susceptibility profile of Cryptococcus spp. isolated from the patients was assessed by broth microdilution. Blood and cerebrospinal fluid fluconazole levels were found to be related to the fluconazole daily dose, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fluconazole; Cryptococcosis; Cerebrospinal fluid.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100011

Fluconazole prophylaxis in preterm infants: a systematic review
Provedor de dados: 55
Autores: Rios,Juliana Ferreira da Silva; Camargos,Paulo Augusto Moreira; Corrêa,Luísa Petri; Romanelli,Roberta Maia de Castro.
ABSTRACT  Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis.  Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants".  Results: Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal; Candida; Fluconazole prophylaxis; Preterm infants.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300333

Fluconazole susceptibility of Brazilian Candida isolates assessed by a disk diffusion method
Provedor de dados: 55
Autores: Colombo,Arnaldo L.; Matta,Daniel da; Almeida,Leila Paula de; Rosas,Robert.
The increasing magnitude of antifungal resistance as well as the advent of new antifungal drugs has generated a renewed interest in fungal susceptibility testing. We used a previously described disk diffusion method to evaluate the susceptibility profile of a large collection of recent clinical Candida spp. isolates against fluconazole. A total of 1,784 yeast isolates were tested, including the following species: Candida albicans (1,036), C. tropicalis (279), C. parapsilosis (202), C. glabrata (119), C. guilliermondii (90), C. krusei (32), C. lusitaniae (7), Candida spp. (14) and other yeasts (5). Susceptibility ranking to fluconazole obtained with all yeasts tested was: C. parapsilosis &lt;FONT FACE=Symbol&gt;@&lt;/FONT&gt; C. tropicalis &lt;FONT...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Fluconazole; Antifungal resistance; Disk diffusion method.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300003

Fluorescent antibody test, quantitative polymerase chain reaction pattern and clinical aspects of rabies virus strains isolated from main reservoirs in Brazil
Provedor de dados: 55
Autores: Appolinário,Camila; Allendorf,Susan Dora; Vicente,Acácia Ferreira; Ribeiro,Bruna Devidé; Fonseca,Clóvis Reinaldo da; Antunes,João Marcelo; Peres,Marina Gea; Kotait,Ivanete; Carrieri,Maria Luiza; Megid,Jane.
ABSTRACTRabies virus (RABV) isolated from different mammals seems to have unique characteristics that influence the outcome of infection. RABV circulates in nature and is maintained by reservoirs that are responsible for the persistence of the disease for almost 4000 years. Considering the different pattern of pathogenicity of RABV strains in naturally and experimentally infected animals, the aim of this study was to analyze the characteristics of RABV variants isolated from the main Brazilian reservoirs, being related to a dog (variant 2),Desmodus rotundus (variant 3), crab eating fox, marmoset, and Myotis spp. Viral replication in brain tissue of experimentally infected mouse was evaluated by two laboratory techniques and the results were compared to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pathogenesis; QRT-PCR; FAT; Rabies; Variants.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500479

Follow-up after infants younger than 2 months of age with urinary tract infection in Southern Israel: epidemiologic, microbiologic and disease recurrence characteristics
Provedor de dados: 55
Autores: Gurevich,Evgenia; Tchernin,Dov; Schreyber,Ruth; Muller,Robert; Leibovitz,Eugene.
Abstract  Background The timing of most recurrences after neonatal urinary tract infection is during the first year of life, with peak incidence 2–6 months after the initial infection. Information on the microbiologic characteristics of recurrent urinary tract infection episodes in relation to the microbiology of the initial episodes is limited.  Objectives To analyze the epidemiologic/microbiological characteristics of 1st and recurrent urinary tract infection in infants &lt;2 months of age.  Methods A retrospective study including all infants &lt;2 months of age with urinary tract infection admitted during 2005–2009 and followed till the age of 1 year.  Results 151 neonates were enrolled (2.7% of all 5617 febrile infants &lt;2 months of age admitted)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; E. coli; Urinary tract infection; Recurrence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100019

Fosfomycin in vitro resistance of Escherichia coli from the community
Provedor de dados: 55
Autores: Biondo,Caroline M; Rocha,Jaime L; Tuon,Felipe Francisco.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100021

Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006
Provedor de dados: 55
Autores: Pourakbari,Babak; Mamishi,Setareh; Mashoori,Negar; Mahboobi,Nastaran; Ashtiani,Mohammad H; Afsharpaiman,Shahla; Abedini,Masomeh.
Appropriate antimicrobial treatment of shigellosis depends on identifying its changing resistance pattern over time. We evaluated 15,255 stool culture submitted from July 2001 to June 2006 to the Laboratory of Children Medical Center Hospital. Specimen culture, bacterial identification, and disk diffusion susceptibility testing were performed according to National Committee for Clinical Laboratory Standards guidelines. From 15,255 stool samples, 682 (4.5%) were positive for Shigella species. The most common species of Shigella were S. flexneri (48%) and S. sonnei (45%); other results were S. dysenteriae (5%) and S. boydii (2%). The rate of Sensitivity to ceftriaxone (95%), ceftizoxime (94%), and nalidixic acid (84%) were among our isolates. Resistance to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Shigella; Antimicrobial susceptibility; Dysentery.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200007

Frequency of adverse events associated to antiretroviral drugs in patients starting therapy in Salvador, Brazil
Provedor de dados: 55
Autores: Vendruscolo,Ornela; Majdalani,Mateus; Mota,Rafael; Luz,Estela; Brites,Carlos.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100108

Frequency of CCR5 genotypes in HIV-infected patients in Roraima, Brazil
Provedor de dados: 55
Autores: Corado,André de Lima Guerra; da Silva,George Allan Villarouco; Leão,Renato Augusto Carvalho; Granja,Fabiana; Naveca,Felipe Gomes.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300019

Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil
Provedor de dados: 55
Autores: Carvalho,André Gordilho Joaquim de; Galvão-Phileto,Ana Verena; Lima,Nana Santos; Jesus,Rogério Santos de; Galvão-Castro,Bernardo; Lima,Manuela Garcia.
Viral infections and chronic diseases have been associated with psychiatric disorders. Among these, increased depression has been reported in HTLV-1 patients. However, no studies on the prevalence of other mental disturbances have been carried out in these patients. Salvador is the city with the highest rate of infection with HTLV-1 in Brazil and it is estimated that approximately 40,000 inhabitants are infected. In our cross sectional study, we examined the frequency of mental disturbances in 50 HTLV-1 seropositive patients followed at the Centro Integrativo e Multidisciplinar de HTLV e Hepatites Virais (CHTLV) of the Escola Bahiana de Medicina e Saude Pública (EBMSP) in Salvador from January to November 2007. We used a questionnaire to collect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV; Mental disturbances.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100003

Frequency of microorganisms isolated in patients with bacteremia in intensive care units in Colombia and their resistance profiles
Provedor de dados: 55
Autores: Cortes,Jorge Alberto; Leal,Aura Lucía; Montañez,Anita María; Buitrago,Giancarlo; Castillo,Juan Sebastián; Guzman,Lucy.
OBJECTIVE: The aim of this study was to describe the most frequently found bacterial microorganisms in bloodstream isolates taken from patients in intensive care units in Colombia and their resistance profiles. METHODS: This was a multicentre descriptive observational study that was carried out between January 2001 and June 2008 with laboratory data from 33 participating hospitals in a surveillance network. RESULTS: The most frequently found microorganisms were coagulase-negative Staphylococci 39.6%, Staphylococcus aureus 12.3%, Klebsiella pneumoniae 8.2%, Escherichia coli 5.7%, Acinetobacter baumannii, 4.0% and Pseudomonas aeruginosa 3.8%. Coagulase-negative Staphylococci registered greater than 70% oxacillin resistance rate. S. aureus presented a change...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteremia; Intensive care unit; Drug resistance; Anti-bacterial agents; Colombia/epidemiology; Epidemiologic surveillance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300007

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
Provedor de dados: 55
Autores: Munerato,Patrícia; Azevedo,Maria Lúcia; Sucupira,Maria Cecília Araripe; Pardini,Regina; Pinto,Gedson Humberto Novaes; Catroxo,Márcia; Souza,Inara Espinelli; Diaz,Ricardo Sobhie.
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CCR5; CCR2B; HIV-1 infection; Polymorphisms.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400002

Frequency of viral etiology in symptomatic adult upper respiratory tract infections
Provedor de dados: 55
Autores: Silva,Raquel Cirlene da; Mendes,Gabriella da Silva; Rojas,Miguel Angel; Amorim,Ariane Ribeiro; Couceiro,José Nelson; Lupi,Omar; Elabras,José; Pires,Gisele; Valle,Solange; Santos,Norma.
Aims: To determine the frequency of viral pathogens causing upper respiratory tract infections in non-hospitalized, symptomatic adults in the city of Rio de Janeiro.Methods:Respiratory samples (nasal/throat swabs) were collected between August 2010 and November 2012 and real time PCR was used to detect different viral pathogens.Results:Viruses were detected in 32.1% (43/134) of samples from 101 patients. Speciﬁcally, 9% (12/134) were positive for HBoV, 8.2% (11/134) were positive for HAdV, 5.2% (7/134) were positive for HRV, and 1.5% (2/134) were positive for FLUBV or HMPV, as single infections. HRSV-A, HPIV-3, and HCoV-HKU1 were detected in one (0.75%) sample each. Co-infections were detected in 4.8% (6/134) of the samples. Peaks of viral infections were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Respiratory infection; Viral infection; Viral diagnosis; Epidemiology.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100030

Fulminant citrobacter meningitis with multiple periventricular abscesses in a three-month-old infant
Provedor de dados: 55
Autores: Anoop,P.; Anjay,M. A.; Vincent,Johny; Girija,B.
Citrobacter, a Gram-negative enteric bacillus, is a rare cause of septicemia and meningitis, seldom reported beyond the neonatal period. It is characterized by a fulminant clinical course and a high incidence of complications, including brain abscesses. We studied a three-month-old infant with Citrobacter meningitis, who developed acute communicating hydrocephalus and multiple periventricular brain abscesses while on treatment. The patient died, despite intensive antibiotic treatment directed towards the causative organism, C. diversus.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Citrobacter; Meningitis; Brain abscess.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600013

Fulminant hepatitis failure in adults and children from a Public Hospital in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Santos,Damião Carlos Moraes dos; Martinho,José Manoel da Silva Gomes; Pacheco-Moreira,Lucio Filgueiras; Araújo,Cristina Carvalho Viana de; Oliveira,Barbara Cristina Euzebio Pereira Dias de; Lago,Barbara Vieira; Pinto,Marcelo Alves; Paula,Vanessa Salete de.
Fulminant hepatic failure (FHF) is characterized by massive hepatocellular injury, whose physiopathology is still unclear. Hepatitis B (HBV) is probably the most common viral cause of FHF, while hepatitis A (HAV) virus seem occurs less frequently. However, the host and viral factors that determine the outcome of these infections are poorly understood. In the present study, viral load and genotyping determining regions of HAV and HBV genomes were sequenced. Eight FHF patients and one patient with severe acute hepatitis (SAH) were included. Liver and blood samples were collected during liver transplantation or necropsy procedures. HAV-RNA and HBV-DNA were extracted from serum, biopsy and paraffin liver. Nucleotide sequencing of HAV-RNA was performed from...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Fulminant hepatitis failure; Hepatitis A virus (HAV); Hepatitis B virus (HBV) and genotype and viral load.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500002

Fulminant pancytopenia due to cytomegalovirus infection in an immunocompetent adult
Provedor de dados: 55
Autores: Koukoulaki,Maria; Ifanti,Georgia; Grispou,Eirini; Papastamopoulos,Vassilios; Chroni,Georgia; Diamantopoulos,Emmanouil; Skoutelis,Athanasios.
A case of severe and irreversible pancytopenia secondary to acute primary cytomegalovirus infection in an immunocompetent woman is described. The patient presented with thrombocytopenia, lymphopenia, anemia, and abnormal liver function tests. Treatment with corticosteroids and intravenous immunoglobulin was ineffective in reconstituting hemopoiesis. The patient developed severe sepsis and eventually expired.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cytomegalovirus; Pancytopenia; Immunocompetent; Fulminant; Irreversible.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200012

Functional assesment of patients with AIDS disease
Provedor de dados: 55
Autores: Zonta,Marise Bueno; Almeida,Sérgio Monteiro de; Carvalho,Mirian T. M. de; Werneck,Lineu César.
We documented the types and degree of functional disability in 74 patients with AIDS at the Hospital de Clínicas of the Federal University of Paraná, Brazil. Few of these patients are referred for rehabilitation services and there is only a limited team approach in their care. We found that 91% of the patients had some degree of functional impairment; in 81% the complaint was weakness and in 47% it was neurological involvement. According to the Barthel Index, 79% were considered functionally independent, 14% partially dependent and 7% dependent. For most of them, independence requires effort and their quality of life is reduced. Severe disability was rather unusual, while mild or moderate disability levels were not. The functional physical disability found...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Rehabilitation; Functional disability; Health status; Neurological manifestation.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500004

Furuncular myiasis due to Cordylobia anthropophaga in a Latin American resident
Provedor de dados: 55
Autores: Joob,Beuy; Wiwanitkit,Viroj.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200157

Fusarium solani keratitis: role of antifungal susceptibility testing and identification to the species level for proper management
Provedor de dados: 55
Autores: Rosa,Priscila Dallé; Sheid,Karla; Locatelli,Claudete; Marinho,Diane; Goldani,Luciano.
ABSTRACT We report a patient with fungal keratitis caused by a multiresistant Fusarium solani in a tertiary care hospital located in southern Brazil. A 55-year-old man with a history of ocular trauma presented with keratitis in left eye. The patient has a complicated clinical course and failed to respond to local and systemic antifungal treatment, and required eye enucleation. Despite multiple topical, intraocular and systemic antifungal treatments, hyphal infiltration persisted in the corneal transplant causing continuous recurrences. The cultures of corneal biopsy scrapings were positive for Fusarium spp. The organism was identified to species level by multi-locus sequencing for translation elongation factor 1 alpha (EF-1α), and RNA polymerase II subunit...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Keratitis; Corneal ulcer; Fusarium solani; Antifungal agents resistance.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300197

Fusarium spp infections in a pediatric burn unit: nine years of experience
Provedor de dados: 55
Autores: Rosanova,María Teresa; Brizuela,Martín; Villasboas,Mabel; Guarracino,Fabian; Alvarez,Veronica; Santos,Patricia; Finquelievich,Jorge.
Abstract  Introduction Fusarium spp are ubiquitous fungi recognized as opportunistic agents of human infections, and can produce severe infections in burn patients. The literature on Fusarium spp infections in pediatric burn patients is scarce.  Objectives To describe the clinical and epidemiological features as well as outcome of Fusarium spp infections in pediatric burn patients.  Patients and methods Retrospective, descriptive study of Fusarium spp infections in a specialized intensive care burn unit.  Results In 15 patients Fusarium spp infections were diagnosed. Median age was 48 months. Direct fire injury was observed in ten patients. The median affected burn surface area was 45%. Twelve patients had a full thickness burn. Fourteen patients had a...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Burn; Fusarium spp; Fungal infections.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400389

Galactomannan detection from piperacillin-tazobactam brands available in the Brazilian market
Provedor de dados: 55
Autores: Xavier,Melissa Orzechowski; Pasqualotto,Alessandro Comarú; Aquino,Valério Rodrigues; Sukiennik,Teresa Cristina Teixeira; Severo,Luiz Carlos.
Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillin-tazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer's instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillin-tazobactam concentrations in the serum. Results were all negative for galactomannan...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Piperacillin-tazobactam; Aspergillosis; Platelia Aspergillus; Galactomannan.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500007

Galactomannan use in clinical practice: providing free testing is not the full answer
Provedor de dados: 55
Autores: dos Santos,Jeniffer S.; Hermes,Djuli M.; Pasqualotto,Alessandro C.
ABSTRACT  Introduction: Invasive aspergillosis is a condition associated with a high mortality rate mostly due to difficulties in performing an early diagnosis. In recent years, galactomannan detection has markedly improved the diagnosis of invasive aspergillosis, but very little is known on how physicians deal with this test in clinical practice.  Methods: This cross-sectional study aimed to analyze the indications for the use of serum galactomannan in a large Brazilian hospital, between 2015 and 2016. No specific protocol was in place for GM request. We reviewed the medical records of adult (&gt;18 years-old) patients who were tested for galactomannan due to one the following indications: screening, diagnosis, or treatment follow-up. Additional variables...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aspergillus; Aspergillosis; Opportunistic infections; Diagnosis; Tomography; Neutropenia; Immunosuppressed.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100037

Gardnerella vaginalis-associated bacterial vaginosis in Bulgarian women
Provedor de dados: 55
Autores: Gergova,Raina T.; Strateva,Tanya V.; Mitov,Ivan G.
ABSTRACT BACKGROUND: Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of reproductive age. The purpose of this study was to determine the frequency of BV in Bulgarian pregnant and nonpregnant women from several age ranges and to compare three different laboratory methods for Gardnerella vaginalis detection in patents suffering from BV. METHODS: Between September 2011 and June 2012, 809 women of 16-40 years of age separated in two major groups: nonpregnant - 469 (355 with and 114 without symptoms) and pregnant - 340 (213 and 127 respectively) were enrolled for the study. The women underwent three different laboratory tests simultaneously: scoring of Gram staining of vaginal smear, culture, and polymerase chain reaction (PCR)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial vaginosis; Gardnerella vaginalis; Bulgarian women.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300002

Gastrointestinal mucormycosis post lung transplantation
Provedor de dados: 55
Autores: Reis,Flavio Pola dos; Campos,Silvia Vidal; Aiello,Vera Demarchi; Duarte,Maria Irma Seixas; Samano,Marcos Naoyuki; Pego-Fernandes,Paulo Manoel.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500368

Gatifloxacin in the treatment of community-acquired pneumonias: a comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
Provedor de dados: 55
Autores: Mendonça,J.S.; Yamaguti,A.; Corrêa,J.C.; Badaró,R.
Community-acquired pneumonia is very common, but some of the cases do require hospitalization for treatment, particularly when older patients and/or co-morbidities are involved; both "typical" and "atypical" respiratory pathogens take part etiologically, and there is increasing concern about the emergence of resistance. There is interest in therapeutic options that can: a) comprehend such a spectrum of bacteria and resistance; b) allow parenteral to oral sequential treatment. We made a multicenter, prospective and randomized trial to compare the "standard" treatment of ceftriaxone IV alone or in combination with erythromycin IV, followed by clarithromycin PO (ceftriaxone treatment arm), with gatifloxacin IV, followed by oral administration (gatifloxacin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftriaxone; Gatifloxacin; Pneumonias.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100006

GBV-C/HGV and HIV-1 coinfection
Provedor de dados: 55
Autores: Maidana,Maria Teresa; Sabino,Ester Cerdeira; Kallas,Esper Georges.
An interesting interaction pattern has been found between HIV-1 and GBV-C/HGV, resulting in protection against progression to AIDS. The mechanisms involved in this interaction remain to be clarified. We examined the current knowledge concerning this coinfection and developed hypotheses to explain its effects. A better understanding of this interaction could result in new concepts, which may lead to new strategies to control HIV-1 replication and progression to AIDS.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HGV; GBV-C; Pathogenesis; Review.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200001

Genetic analysis of the first mcr-1 positive Escherichia coli isolate collected from an outpatient in Chile
Provedor de dados: 55
Autores: Gutiérrez,Camila; Zenis,Javier; Legarraga,Paulette; Cabrera-Pardo,Jaime R.; García,Patricia; Bello-Toledo,Helia; Opazo-Capurro,Andrés; González-Rocha,Gerardo.
ABSTRACT Global dissemination of mcr-like genes represents a serious threat to public health since it jeopardizes the effectiveness of colistin, an antibiotic used as a last-resort treatment against highly antibiotic-resistant bacteria. In 2017, a mcr-1-positive isolate of Escherichia coli was found in Chile for the first time. Herein we report the genetic features of this strain (UCO-457) by whole-genome sequencing (WGS) and conjugation experiments. The UCO-457 strain belonged to ST4204 and carried a 285 kb IncI2-type plasmid containing the mcr-1 gene. Moreover, this plasmid was transferred by conjugation to an E. coli J53 strain at high frequency. The isolate harbored the cma, iroN, and iss virulence genes and did carry resistance genes to...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Colistin-resistance; Mcr-1; Escherichia coli; Chile.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300203

Genetic characterization and evolutionary inference of TNF-α through computational analysis
Provedor de dados: 55
Autores: Awasthi,Gauri; Singh,Suchita; Dash,A.P.; Das,Aparup.
TNF-α is an important human cytokine that imparts dualism in malaria pathogenicity. At high dosages, TNF-α is believed to provoke pathogenicity in cerebral malaria; while at lower dosages TNF-α is protective against severe human malaria. In order to understand the human TNF-α gene and to ascertain evolutionary aspects of its dualistic nature for malaria pathogenicity, we characterized this gene in detail in six different mammalian taxa. The avian taxon, Gallus gallus was included in our study, as TNF-α is not present in birds; therefore, a tandemly placed duplicate of TNF-α (LT-α or TNF-β) was included. A comparative study was made of nucleotide length variations, intron and exon sizes and number variations, differential compositions of coding to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; TNF-α; TNF-β; Evolution; Computational analyses.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500006

Genetic diversity of human immunodeficiency virus-1 isolates in Paraná, Brazil
Provedor de dados: 55
Autores: Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Rossi,Silvia Gomes de; Brindeiro,Rodrigo; Queiroz-Telles,Flávio de.
OBJECTIVE: Because epidemiological data on circulating HIV subtypes among HIV-positive patients in the state of Paraná were not known until now, the aims of this study were to describe the genetic diversity profile of HIV-1 in treated patients in Paraná, Brazil, and report the differences in protease (PR) and reverse transcriptase (RT) mutations in HIV-1 subtypes. PATIENTS AND METHODS: A cross-sectional study was conducted from 2003 to 2006. Plasma viral RNA of 389 patients was extracted and PR and RT genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined for antiretroviral resistance mutations. Data on gender of patient harboring the viruses and past history of antiretroviral treatment were also collected....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1 subtypes; Genotype; Antiretroviral; Drug experienced patients.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300006

Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Kohat District, Pakistan
Provedor de dados: 55
Autores: Khatoon,Lubna; Khan,Inam Ullah; Shah,Shahid Ali; Jan,Muhammad Ishtiaq; Ullah,Farhat; Malik,Salman Akbar.
Malaria is one of the serious diseases threatening human health in Pakistan and contributes to a large proportion of the total malaria deaths in South Asia. However, little is known about the nature and extent of genetic diversity of the malarial parasites circulating in Pakistan. This study was designed to assess the infection status of Plasmodium and the genetic diversity of Plasmodium vivax and Plasmodium falciparum by analyzing msp-3α, msp-3β and msp-1, msp-2 genes respectively using allele specific nested PCR and RFLP assays. For this purpose, 130 field isolates were collected from the individuals who exhibited clinical symptoms associated with malaria in the Kohat region of Khyber Pakhtoonkhwa (KPK), Pakistan. Among 130 blood samples collected, P....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Plasmodium vivax; Plasmodium falciparum; Genetic variation; Pakistan.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200014

Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
Provedor de dados: 55
Autores: Longhi,Renata Maronna Praça; Zembrzuski,Verônica Marques; Basta,Paulo Cesar; Croda,Julio.
We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Immune response; Indigenous populations; Polymorphism.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300009

Genetic similarity of Burkholderia cenocepacia from cystic fibrosis patients
Provedor de dados: 55
Autores: Pretto,Luana; de-Paris,Fernanda; Machado,Alice Beatriz Mombach Pinheiro; Martins,Andreza Francisco; Barth,Afonso Luís.
Burkholderia cenocepacia may cause serious infections in patients with cystic fibrosis, and this microorganism can be highly transmissible. Pulsed-field gel electrophoresis is widely used to study the dynamics of strain spread in cystic fibrosis patients. The aim of this work was to perform pulsed-field gel electrophoresis-based molecular typing of B. cenocepacia isolates to evaluate the epidemiology of this species at our hospital. A total of 28 isolates from 23 cystic fibrosis patients were analyzed. Initially, we compared isolates obtained from the same patient at different periods of time. We then compared the pulsed-field gel electrophoresis profiles of 15 IIIA isolates, and in a third analysis, evaluated the genetic profile of 8 IIIB isolates from...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Burkholderia cenocepacia; Cystic fibrosis; PFGE; Genetic similarity.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100014

Genital schistosomiasis mansoni concomitant to genital tumor in areas of low endemicity: challenging diagnosis
Provedor de dados: 55
Autores: Cavalcanti,Marta G; Gonçalves,Margareth MI; Barreto,Magali M; Silva,Aline Helen da; Madi,Kalil; Peralta,José Mauro; Igreja,Ricardo P.
Genital infection by Schistosoma mansoni is usually misdiagnosed in individuals who reside in, or travel to endemic areas. We describe two cases of genital tumor associated with S. mansoni infection manifested by methrorragy. Surgical specimens revealed leiomyomas in both cases associated with S. mansoni. In one of them, granulomas were found in the ovary and in the other they were found in the uterine tube. Although none presented intestinal/hepatic disease, fecal egg excretion was detected in one. Both had elevated pretreatment antibody reactivity to S. mansoni antigen, but follow-up showed different outcomes. Schistosomiasis should be considered as a diagnosis in individuals with methrorragy residing in or having traveled to endemic areas. Since...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: S. mansoni; Female genital infection; Serology; Low endemic area.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200016

Genital ulcers in women: clinical, microbiologic and histopathologic characteristics
Provedor de dados: 55
Autores: Gomes,Christiane Maria Moreira; Giraldo,Paulo César; Gomes,Francis de Assis Moraes; Amaral,Rose; Passos,Mauro Romero Leal; Gonçalves,Ana Katherine da Silveira.
Female genital ulcer is a disease that affects a large number of women, and its etiologic diagnosis can be difficult. The disease may increase the risk of acquiring HIV. Genital ulcer may be present in sexually transmitted diseases (STD) - syphilis, chancroid, genital herpes, donovanosis, lymphogranuloma venereum and other non-STD disorders (NSTD) - Behçet's syndrome, pemphigus, Crohn's disease, erosive lichen planus and others. This study evaluated the clinical-histopathologic-microbiologic characteristics of female genital ulcers. A cross-sectional descriptive prospective study was conducted during a six-month period to investigate the first 53 women without a definitive diagnosis, seeking medical care for genital ulcers at a genital infections...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Female genital ulcer; STD; Herpes virus; Behçet's syndrome; Syndromic ulcer management; Vulvar disease; Vulvar vasculitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200018

Genomic features of a clinical ESBL-producing and colistin-resistant hypermucoviscous K. quasipneumoniae subsp. similipneumoniae from Brazil
Provedor de dados: 55
Autores: Ferreira,Melina Lorraine; Araújo,Bruna Fuga; Cerdeira,Louise Teixeira; Toshio,César; Ribas,Rosineide Marques.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300207

Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast Brazil
Provedor de dados: 55
Autores: Medeiros,Melissa Soares; Arruda,Érico Antônio Gomes; Guerrant,Richard Littleton; Brown,Christopher; Hammarskjold,Marie-Louise; Rekosh,David; Lima,Aldo Ângelo Moreira.
Genotype testing for HIV-1 drug resistance is useful for selecting antiretroviral drug regimens for patients experiencing therapeutic failure, but the optimal means for interpreting the test results is unknown because many HIV-1 protease and reverse transcriptase (RT) mutations contribute to drug resistance. This study identified common combinations of resistance mutations related to antiretroviral resistance profiles. From April 2002 to March 2004, 101 protease and RT sequences were determined for HIV-1 isolates from patients who were failing antiretroviral therapy. The resistance profile was evaluated using the Stanford Database program. Male patients predominated (76.2%), the median age was 38 years, the average CD4 count was 279.21 cells/mm³ and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genotype test mutation HIV-1 protease reverse transcriptase antiretrovirals; Resistance.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400003

Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective
Provedor de dados: 55
Autores: Riccetto,Adriana Gut Lopes; Silva,Luciana Helena Antoniassi da; Spilki,Fernando Rosado; Morcillo,André Moreno; Arns,Clarice Weis; Baracat,Emílio Carlos Elias.
The aim of this study was to determine if there was a correlation between respiratory syncytial virus (RSV) and metapneumovirus (MPV) genotypes and clinical data of Brazilian infants hospitalized for acute lower respiratory infection. The viruses in the patients' nasopharyngeal secretions were studied using the polymerase chain reaction and phylogenetic analysis. The study assessed 144 infants; 31.9% were RSV positive and 5.6% were MPV positive. Statistical analysis was performed using the chi-squared test, Fisher's test, Odds ratio, univariate logistic regression, non-conditional multivariate logistic regression and the forward - stepwise method. Multivariate analysis confirmed a significant relationship between a positive PCR test for RSV and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Respiratory syncytial virus; Metapneumovirus; Genotypes; Infants; Clinical.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100008

Genotypic study documents divergence in the pathogenesis of bloodstream infection related central venous catheters in neonates
Provedor de dados: 55
Autores: Brito,Cristiane Silveira; Ribas,Rosineide Marques; Resende,Daiane Silva; Brito,Denise Von Dolinger de; Abdallah,Vânia Olivetti Steffen; Santos,Kátia Regina Netto dos; Cavalcante,Fernanda Sampaio; Matos,Pricilla Dias Moura de; Gontijo Filho,Paulo P.
OBJECTIVE: To investigate the pathogenesis of bloodstream infection by Staphylococcus epidermidis, using the molecular epidemiology, in high-risk neonates. METHODS: We conducted a prospective study of a cohort of neonates with bloodstream infection using central venous catheters for more than 24 h. "National Healthcare Safety Network" surveillance was conducted. Genotyping was performed by DNA fingerprinting and mecA genes and icaAD were detected by multiplex-PCR. RESULTS: From April 2006 to April 2008, the incidence of bloodstream infection and central venous catheter-associated bloodstream infection was 15.1 and 13.0/1000 catheter days, respectively, with S. epidermidis accounting for 42.9% of episodes. Molecular analysis was used to document the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neonates; Central venous catheter; Pathogenesis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400387

Genotyping and drug resistance patterns of Mycobacterium tuberculosis strains observed in a tuberculosis high-burden municipality in Northeast, Brazil
Provedor de dados: 55
Autores: Luiz,Roberta dos Santos Silva; Suffys,Phillip; Barroso,Elizabeth Clara; Kerr,Ligia Regina Franco Sansigolo; Duarte,Cynthia Romariz; Freitas,Max Victor Carioca; Mota,Rosa Maria Salani; Frota,Cristiane Cunha.
OBJECTIVES: This study has used a combination of clinical information, spoligotyping, and georeferencing system to elucidate the genetic diversity of the Mycobacterium tuberculosis isolates circulating in a TB-prevalent municipality of Northeast Brazil. METHODS: A total of 115 M. tuberculosis strains were isolated from pulmonary tuberculosis patients from January 2007 to March 2008 in Fortaleza. Drug susceptibility and spoligotyping assays were performed and place of residence of the patients were georeferenced. RESULTS: Of the M. tuberculosis strains studied, 51 (44.3%) isolates were resistant to at least one drug (R-TB) and 64 (55.7%) were sensitive to all the drugs tested (S-TB). A high frequency of resistance was found in previously treated cases (84%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Drug-resistant tuberculosis; Georeferencing; Spoligotyping.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300006

Geolocalization of HIV-1 subtypes and resistance mutations of patients failing antiretroviral therapy in Salvador - Brazil
Provedor de dados: 55
Autores: Oliveira Filho,Antonio Walter de; Brites,Carlos.
ABSTRACT  Background: Geographical distribution of HIV variants is an important way to understand the circulation and spread of such viral strains.  Objectives: To evaluate the spatial distribution of HIV-1 variants in patients failing antiretroviral therapy, in Salvador, Brazil.  Methods: We performed a cross-sectional evaluation of HIV resistance test reports of patients who underwent genotyping tests in a referral center in Salvador, Brazil, for the years 2008-2014. The laboratory database contains around 2500 resistance reports of patients failing antiretroviral therapy. Genotypic tests were performed by sequencing of HIV-1 POL region (TrueGene, Siemens). We assessed HIV-1 resistance mutations and subtype, as well as residential address, age, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Resistance mutations; Brazil; Geolocalization.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300234

Georeferencing of deaths from sepsis in the city of São Paulo
Provedor de dados: 55
Autores: Diament,Décio; Colombari,Fernando; Cypriano,Adriana Serra; Lisboa,Luis Fernando; dos Santos,Bento Fortunato Cardoso; Cendoroglo Neto,Miguel; Serpa Neto,Ary; Silva,Eliezer.
Abstract  Objective The aim of the present study was to obtain information about deaths due to sepsis in São Paulo from 2004 to 2009 and their relationship with geographical distribution.  Methods Causes of death, both main and secondary, were defined according to the codes of the International Classification of Disease version 10 (ICD-10) contained in the database. Sepsis, septic shock, multiple organ failure, pneumonia, urinary tract infection, peritonitis and other intraabdominal infections, skin and soft tissue infections (including surgical wound infection) and meningitis were considered as immediate cause of death or as the condition leading to the immediate cause of death related or associated to sepsis.  Results In the analyzed period, there was a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Mortality; Infection; Georeferencing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200149

Gestational toxoplasmosis in Paraná State, Brazil: prevalence of IgG antibodies and associated risk factors
Provedor de dados: 55
Autores: Lopes-Mori,Fabiana Maria Ruiz; Mitsuka-Breganó,Regina; Bittencourt,Laura Helena França de Barros; Dias,Renata Cristina Ferreira; Gonçalves,Daniela Dib; Capobiango,Jaqueline Dario; Reiche,Edna Maria Vissoci; Morimoto,Helena Kaminami; Freire,Roberta Lemos; Navarro,Italmar Teodorico.
The aim of the present study was to verify the association between seropositivity for IgG anti-Toxoplasma gondii antibodies and social, economic and environmental variables of pregnant women attending the public health centers of Paraná, Brazil. From January 2007 to July 2010, 2226 pregnant women were interviewed and detection of anti-T. gondii specific IgG and IgM antibodies was performed by chemiluminescence test. Seropositivity for anti-T. gondii IgG was observed in 1151 (51.7%) pregnant women, 29 of which (1.3%) presented IgM reagent with IgG of high avidity. The variables associated with the presence of IgG were residency in the rural area, more than one pregnancy, less than or equal to eight years schooling, low per capita income, age group, raw or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Seroepidemiology; Prevalence; Toxoplasmosis; Pregnancy.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400004

Ghost tablets mimicking intestinal parasite
Provedor de dados: 55
Autores: Porte,Lorena; Weitzel,Thomas.
Tipo: Info:eu-repo/semantics/report
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600462

Giant squamous cell carcinoma in HIV-positive patient
Provedor de dados: 55
Autores: Ferreira,Cassio Porto; Valle,Heliomar de Azevedo; Ferreira,José Alvimar; Lima,Ricardo Barbosa; Martins,Carlos José.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200020

Giardiasis as zoonosis: between proof of principle and paradigm in the Northwestern region of São Paulo State, Brazil
Provedor de dados: 55
Autores: Volotão,Aline Cardoso Caseca; Ramos,Nathália Motta Delvaux; Fantinatti,Maria; Moraes,Marcus Vinícius Proença de; Atique Netto,Halim; Storti-Melo,Luciane Moreno; Godoy,Elenir Alves Macedo de; Rossit,Andréa Regina Baptista; Fernandes,Octávio; Machado,Ricardo Luiz Dantas.
OBJECTIVE: In order to evaluate the potential zoonotic transmission of Giardia duodenalis, isolates from humans and dogs in the Northwestern region of the São Paulo State, Brazil were characterized based on the β-giardin gene. METHODS: The samples were analyzed by sequencing of the Nested-PCR products. RESULTS: The A1 and A2 subgenotypes were detected in human and dogs. Cysts of assemblage B, C and D have not been found in any isolates studied. CONCLUSIONS: These results are consistent with the view that giardiasis in the largest endemic region of the Brazil should not be seen as a single entity.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Giardia duodenalis; Beta giardin gene; Genotypes; Zoonosis; Brazil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400014

Grading and staging chronic hepatitis C and its relation to genotypes and epidemiological factors in brazilian blood donors
Provedor de dados: 55
Autores: Silva,Giovanni Faria; Nishimura,Nancy F.; Coelho,Kunie Iabuki Rabello; Soares,Elza Cotrim.
Progression of chronic hepatitis C is known to be associated with some factors, but influence of HCV genotypes is still controversial. Association between HCV genotypes and other risk factors was examined to determine which factors are associated with progression of infection. One hundred consecutive anti-HCV positive volunteer blood donors were evaluated for several risk factors, examined for HCV genotypes, and submitted to hepatic biopsy and biochemical exams.HCV genotyping were carried out in 89 patients and hepatic biopsy in 78. Transmission routes were found to be illicit intravenous drug use (26%), Gluconergan® use in a non-safe manner (48%) and blood transfusion (15%). HCV genotype was 1 in 45%, 3 in 40%, and it was not associated with the stage of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Fibrosis; Risk factors.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200004

Gram-negative osteomyelitis: clinical and microbiological profile
Provedor de dados: 55
Autores: Carvalho,Vladimir Cordeiro de; Oliveira,Priscila Rosalba Domingos de; Dal-Paz,Karine; Paula,Adriana Pereira de; Félix,Cássia da Silva; Lima,Ana Lúcia Lei Munhoz.
INTRODUCTION: Despite the growing interest in the study of Gram-negative bacilli (GNB) infections, very little information on osteomyelitis caused by GNB is available in the medical literature. OBJECTIVES AND METHODS: To assess clinical and microbiological features of 101 cases of osteomyelitis caused by GNB alone, between January 2007 and January 2009, in a reference center for the treatment of high complexity traumas in the city of São Paulo. RESULTS: Most patients were men (63%), with median age of 42 years, affected by chronic osteomyelitis (43%) or acute osteomyelitis associated to open fractures (32%), the majority on the lower limbs (71%). The patients were treated with antibiotics as inpatients for 40 days (median) and for 99 days (median) in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteomyelitis Fractures; Open Gram-negative bacterial infections Accidents; Traffic.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100011

Group B Streptococcus detection: comparison of PCR assay and culture as a screening method for pregnant women
Provedor de dados: 55
Autores: de-Paris,Fernanda; Machado,Alice Beatriz Mombach Pinheiro; Gheno,Tailise Conte; Ascoli,Bruna Maria; Oliveira,Kátia Ruschel Pilger de; Barth,Afonso Luis.
Streptococcus agalactiae or group B Streptococcus (GBS) is one of the most important causal agents of serious neonatal infections. Numerous assays have been evaluated for GBS screening in order to validate a fast and efficient method. The aim of this study was to compare the culture technique (established as the gold standard) with the molecular method of polymerase chain reaction (PCR) with specific primers (atr gene). Two hundred and sixty-three samples were analyzed. Vaginal samples were collected, according to the Centers for Disease Control and Prevention (CDC) recommendations, from women over 35 weeks of pregnancy at Hospital de Clínicas de Porto Alegre (HCPA). Two different extraction methods were tested in all samples collected. PCR technique...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus agalactiae; Polymerase chain reaction; Culture; Pregnancy.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400004

Group B streptococcus neonatal infection in an intensive care unit in Brazil: high fatality and missed opportunities for antibiotic prophylaxis
Provedor de dados: 55
Autores: Evangelista,Marilia Lopes Bahia; Freitas,Felipe Teixeira de Mello.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100098

H5N1 avian influenza virus: an overview
Provedor de dados: 55
Autores: Proença-Módena,José Luiz; Macedo,Izolete Santos; Arruda,Eurico.
Avian influenza virus (H5N1) emerged in Hong Kong in 1997, causing severe human disease. In recent years, several outbreaks have been reported in different parts of Asia, Europe and Africa, raising concerns of dissemination of a new and highly lethal influenza pandemic. Although H5N1 has not been capable of sustaining human-to-human transmission, the ability of the virus to undergo variation due to mutations and reassortment, clearly poses the possibility of viral adaptation to the human species. For this reason the World Health Organization has established that we are now in a phase of pandemic alert. Preparing for an influenza pandemic involves a great deal of awareness necessary to stop initial outbreaks, through the use of case recognition, sensitive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: H5N1 avian influenza virus; Pandemic influenza; Oseltamivir.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100027

HAM/TSP and major depression: the role of age
Provedor de dados: 55
Autores: Boa-Sorte,Ney; Galvão-Castro,Ana Verena; Borba,Danilo; Lima,Renan Barbalho Nunes de Castro; Galvão-Castro,Bernardo.
Objective: To investigate the role of demographic variables in the relationship between the presence of HAM/TSP and current major depression.Methods: It is a cross-sectional study of 108 HTLV-1 infected patients (47 with TSP/HAM) resident of Salvador, Brazil. The Mini International Neuropsychiatric Interview, Brazilian Version 5 was used to evaluate the presence of depression. Prevalence ratios were used to describe relationship between HAM/TSP and depression. The HAM/TSP classification was carried out according to the criteria proposed by Castro-Costa et al.Results: Prevalence of depression was 37.96%. No association was observed between presence of HAM/TSP and diagnosis of current major depression in the global analysis of patients (PR: 0.94; CI 95%:...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Depression; Human T-lymphotropic virus 1; Age factors; HTLV-1 associated myelopathies.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300314

Hand, foot, and mouth disease in an adult
Provedor de dados: 55
Autores: Akkoyunlu,Yasemin; Ceylan,Bahadır; Aslan,Turan.
Tipo: Info:eu-repo/semantics/article
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200227

Hantavirus infection in HIV positive individuals in Rio de Janeiro, Brazil: a seroprevalence study
Provedor de dados: 55
Autores: Lamas,Cristiane da Cruz; Oliveira,Renata de; Silva,Raphael Gomes da; Vicente,Luciana Helena Bassan; Almeida,Endiá Barros de; Lemos,Elba Regina Sampaio de; Bóia,Márcio Neves.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100026

Hantavirus pulmonary syndrome: when should you consider this diagnosis?
Provedor de dados: 55
Autores: Carneiro,Marcelo; Koch,Bruna Elisa; Krummenauer,Eliane C; Machado,Janete Aparecida.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300022

HBV epidemiology and genetic diversity in an area of high prevalence of hepatitis B in southern Brazil
Provedor de dados: 55
Autores: Paoli,Juliana de; Wortmann,André Castagna; Klein,Mirelli Gabardo; Pereira,Vagner Reinaldo Zingalli Bueno; Cirolini,Adriana Maria; Godoy,Bibiane Armiliato de; Fagundes,Nelson Jurandi Rosa; Wolf,Jonas Michel; Lunge,Vagner Ricardo; Simon,Daniel.
ABSTRACT  Background Hepatitis B virus (HBV) infection is a major public health problem in Brazil. HBV endemicity is usually moderate to low according to geographic regions, and high prevalence of this virus has been reported in people of some specific Brazilian counties, including those with a strong influence of Italian colonization in southern Brazil. Analysis of HBV diversity and identification of the main risk factors to HBV infection are necessary to understand hepatitis B epidemiology in these high prevalence regions in southern Brazil.  Objective To investigate epidemiological characteristics and HBV genotypes and subgenotypes circulating in a specific city with high HBV prevalence.  Methods A cross-sectional study was performed with 102 HBV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV infection; Epidemiology; HBV genotypes; Risk factor; Transmission; Cross-sectional studies.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400294

HBV, HCV and HIV seroprevalence among blood donors in Istanbul, Turkey: how effective are the changes in the national blood transfusion policies?
Provedor de dados: 55
Autores: Acar,Ali; Kemahli,Sabri; Altunay,Husnu; Kosan,Erdogan; Oncul,Oral; Gorenek,Levent; Cavuslu,Saban.
The national blood transfusion policies have been changed significantly in recent years in Turkey. The purpose of this study was to determine the prevalence of HBV, HCV, and HIV in blood donors at the Red Crescent Center in Istanbul and to evaluate the effect of changes in the national blood transfusion policies on the prevalence of these infections. The screening results of 72695 blood donations at the Red Crescent Center in Istanbul between January and December 2007 were evaluated retrospectively. HBsAg, anti-HCV, and anti-HIV-1/2 were screened by microparticle enzyme immunoassay (MEIA) method. Samples found to be positive for anti-HIV 1/2 and anti-HCV were confirmed by Inno-Lia HCV Ab III and Inno-Lia HIV I/II Score, respectively. The seropositivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HCV; HIV; Seroprevalence; Blood donors; Turkey.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100009

HCV genotype 4 circulating in the city of Franca, São Paulo state, Brazil
Provedor de dados: 55
Autores: Grotto,Rejane Maria Tommasini; Corvino,Silvia Maria; Padovani,Juliana Lara; Siqueira,Sônia Maria de Coppio; Pardini,Maria Inês de Moura Campos.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300023

HCV virological response during treatment of chronic hepatitis C is associated with liver histological Improvement in patients with HCV/HIV co-infection
Provedor de dados: 55
Autores: Castro,Gleusa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sérgio; Martinelli,Ana de Lourdes Candolo; Figueiredo,José Fernando de Castro.
Liver histological improvement after treatment for chronic hepatitis C in patients co-infected with human immunodeficiency virus-1 (HIV-1) has been described. Paired liver biopsies in twenty six HCV/HIV co-infected patients were compared to determine factors possibly associated with histological improvement. The patients were submitted to a liver biopsy before treatment for hepatitis C and 25 months after the end of treatment. Fragments of the liver biopsy obtained before and after treatment were compared regarding the following parameters: histological activity index (HAI) and degree of fibrosis (Knodell); intensity of collagen deposits (Sirius Red staining) and degree of stellate cell activation (alpha-smooth muscle actin labeling). The ratios of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Hepatic stellate cell; Histological response; Human immunodeficiency virus; Paired liver biopsies.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300004

Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis
Provedor de dados: 55
Autores: Reis,Michelle Cristina Guerreiro dos; Rabahi,Marcelo Fouad; Kipnis,André; Junqueira-Kipnis,Ana Paula.
Tuberculosis (TB) is one of the oldest human infectious diseases and one third of the world's population is latently infected. Brazil is an endemic area for TB. One of the most important challenges in TB control is the identification of latently infected individuals. Health Care Workers (HCW) are at high risk of being infected with Mycobacterium tuberculosis and even to become TB latently infected. The aim of this study was to increase knowledge about humoral immune response in TB latently infected individuals. HCW were classified according to their tuberculin skin test (TST), as positive or negative. The antibody response to GLcB, MPT51 and HSPX from Mycobacterium tuberculosis was evaluated. TST negative HCW constituted the majority of those who showed a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Latent tuberculosis; Infection; Antibodies.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600006

Health care-related infections in solid organ transplants
Provedor de dados: 55
Autores: Sola,A.F.; Bittencourt,A.R.C.; Guerra,C.M.; Godoy,H.L.; Medeiros,E.A.S.
The health care-related infections are well-known in a critical care setting, but reports of those infections in solid organ transplanted patients are scarce. We developed a study of retrospective cohort in a tertiary teaching hospital for 14 months. Eighty-one patients underwent solid organ transplants. The global incidence of health care-related infection was 42.0%. Fifteen percent of the cases were occurrences of surgical site infections, 14.0% pneumonias, 9.0% primary blood stream infections, 4.0% urinary tract infections and 2.0% skin infection. The most prevalent etiologic agents were K. pneumoniae (8.6%), P. aeruginosa (7.4%); A. baumannii (5.0%) and S. aureus (2.5%). Mortality was 18.0%, none of then related to health care infections. The high rate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Transplantation; Health care-related infections; Immunocompromised patients; Infection control.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600008

Health related quality of life among patients with chronic hepatitis C: a cross-sectional study of sociodemographic, psychopathological and psychiatric determinants
Provedor de dados: 55
Autores: Fábregas,Bruno Cópio; Ávila,Renata Eliane de; Faria,Marjore Novaes; Moura,Alexandre Sampaio; Carmo,Ricardo Andrade; Teixeira,Antonio Lúcio.
INTRODUCTION: Chronic hepatitis C virus infection patients have higher rates of psychiatric disorders than the general population. Chronic hepatitis C virus infection is known to be associated with impaired health related quality of life. To our knowledge, there is no previous research of health related quality of life in chronic hepatitis C patients that combined structured psychiatric interview and careful psychopathological evaluation, including depression, anxiety and fatigue instruments. The aim of this study was to evaluate health related quality of life of chronic hepatitis C patients and to investigate the association with sociodemographic, psychopathological and psychiatric factors. MATERIALS AND METHODS: Eighty-one individuals with chronic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quality of life; WHOQOL-BREF; Hepatitis C; Depression; Fatigue.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600002

Health surveillance, biosafety and emergence and re-emergence of infectious diseases in Brazil
Provedor de dados: 55
Autores: Cardoso,Telma Abdalla de Oliveira; Navarro,Marli BM de Albuquerque; Costa Neto,Cristina; Moreira,Josino Costa.
The present paper presents compulsory notification data for infectious diseases and epidemiologic ones recorded at the Center for Strategic Information and Health Surveillance (CIEVS) for the period of March 2006 to April 2007. Data is presented in accordance with geographic distribution, time and risk classification of the etiologic agents found, according to Ministry of Health regulations. The importance of this epidemiologic surveillance system is presented, debating the main topics required for quality improvement and information analysis. It is concluded, from the analysis of epidemiologic events and their relation to risk management, that the compulsory notification system in Brazil is incomplete, irregular, delayed and, in a large percentage of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Biosafety; Epidemiologic surveillance; Infectious diseases; Public health.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500018

Healthcare-associated Staphylococcus aureus bloodstream infection: length of stay, attributable mortality, and additional direct costs
Provedor de dados: 55
Autores: Primo,Mariusa Gomes Borges; Guilarde,Adriana Oliveira; Martelli,Celina M. Turchi; Batista,Lindon Johnson de Abreu; Turchi,Marília Dalva.
This study aimed to determine the excess length of stay, extra expenditures, and attributable mortality to healthcare-associated S. aureus bloodstream infection (BSI) at a teaching hospital in central Brazil. The study design was a matched (1:1) case-control. Cases were defined as patients &amp;gt; 13 years old, with a healthcare-associated S. aureus BSI. Controls included patients without an S. aureus BSI, who were matched to cases by gender, age (± 7 years), morbidity, and underlying disease. Data were collected from medical records and from the Brazilian National Hospital Information System (Sistema de Informações Hospitalares do Sistema Único de Saúde - SIH/SUS). A Wilcoxon rank sum test was performed to compare length of stay and costs between cases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Bloodstream infection; Attributable mortality; Length of stay; Extra costs.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600001

Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
Provedor de dados: 55
Autores: Rech,Tássia Flores; Mazzoleni,Luiz Edmundo; Mazzoleni,Felipe; Francesconi,Carlos Fernando de Magalhães; Sander,Guilherme Becker; Michita,Rafael Tomoya; Nabinger,Débora Dreher; Milbradt,Tobias Cancian; Torresini,Ronaldo João Spinato; Simon,Daniel.
ABSTRACT  Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia.  Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism.  Results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Dyspepsia; Interleukin-1beta; Polymorphism; Inflammation.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400311

Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors
Provedor de dados: 55
Autores: Rodrigues,Maria N.; Queiroz,Dulciene M. M.; Rodrigues,Rodrigo T.; Rocha,Andreia M.C.; Braga Neto,Manuel B.; Braga,Lucia L.B.C.
We investigated the prevalence and the risk factors for infection with Helicobacter pylori in a randomly-selected population of adults from a low-income community in Northeastern Brazil. Helicobacter pylori infection was determined by ELISA. Risk factors were assessed using a structured interview. Two hundred and four individuals were included in the study, including 49 males and 155 females, ranging from 18 to 80 years old. Overall, 165 of 204 participants (80%) were H. pylori positive, without significant gender differences (p= 0.49). The infection rate was of 84.7% in subjects 18 to 30 years of age, increasing to 92% in subjects 46-60 years old. Above 60 years old, the prevalence decreased slightly. As a whole, the prevalence of infection did not...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Prevalence; Risk factors; Northeastern Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500008

Hematological particularities and co-infections in injected drug users with AIDS
Provedor de dados: 55
Autores: Brunetta,Denise Menezes; De Santis,Gil Cunha; Vilar,Fernando Crivelenti; Brandão,Renata Amorim; Muniz,Renata Zomer de Albernaz; Lima,Geovana Momo Nogueira de; Amorelli-Chacel,Manuela Emiliana; Covas,Dimas Tadeu; Machado,Alcyone Artioli.
HIV patients infected through injected drug use have poorer prognosis than other groups. We evaluated the hematological alterations and rates of co-infections in injected drug use patients with AIDS. Injected drug use patients were younger, predominantly of male gender, and presented lower CD4, total lymphocyte, and platelet counts, but not neutrophil count, than control group. Injected drug use patients had a higher rate of hepatitis C and mycobacteria infection. Furthermore, all injected drug use patients with hemoglobin &lt;10.0 g dL-1 and lymphocyte &lt;1000 µL-1 had CD4 count lower than 100 µL-1. In conclusion, HIV-infected injected drug use patients constitute a special group of patients, and hemoglobin concentration and lymphocyte count can be used...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Injected drug use; Anemia; HCV; Mycobacteria.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600005

Hemophagocytic syndrome associated with cytomegalovirus infection in a severely immunocompromised AIDS patient: case report
Provedor de dados: 55
Autores: Nogueira,Marcus V.F.; Vidal,Laira; Terra,Bruno; Pagot,Thiago; Salluh,Jorge I.F.; Soares,Márcio.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100016

Hemorrhagic encephalopathy in dengue shock syndrome: a case report
Provedor de dados: 55
Autores: Souza,Luiz José de; Martins,André Luiz de Oliveira; Paravidini,Paulo César Leitão; Nogueira,Rita Maria Ribeiro; Gicovate Neto,Carlos; Bastos,Diogo Assed; Siqueira,Edno Wallace da Silva; Carneiro,Rodrigo da Costa.
Dengue fever is the most important arboviral infection in the world, with an estimated 100 million cases per year and 2.5 billion people at risk. Encephalopathy is a rare complication of dengue virus infection and may occur as a consequence of intracranial hemorrhage, cerebral edema, hyponatremia, cerebral anoxia, fulminant hepatic failure with portosystemic encephalopathy, microcapillary hemorrhage or release of toxic products. We report a rare case of hemorrhagic encephalopathy in dengue shock syndrome caused by type 3 dengue virus.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue fever; Encephalopathy; Cerebral hemorrhage.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300009

Hepatic amebiasis
Provedor de dados: 55
Autores: Salles,José Maria; Moraes,Luis Alberto; Salles,Mauro Costa.
Amebiasis can be considered the most aggressive disease of the human intestine, responsible in its invasive form for clinical syndromes, ranging from the classic dysentery of acute colitis to extra-intestinal disease, with emphasis on hepatic amebiasis, unsuitably named amebic liver abscess. Found worldwide, with a high incidence in India, tropical regions of Africa, Mexico and other areas of Central America, it has been frequently reported in Amazonia. The trophozoite reaches the liver through the portal system, provoking enzymatic focal necrosis of hepatocytes and multiple micro-abscesses that coalesce to develop a single lesion whose central cavity contains a homogeneous thick liquid, with typically reddish brown and yellow color similar to "anchovy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Entamoeba histolytica; Hepatic ameabiasis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200002

Hepatitis A: the costs and benefits of the disease prevention by vaccine, Paraná, Brazil
Provedor de dados: 55
Autores: Zahdi,Mariana Ribas; Maluf Junior,Ivan; Maluf,Eliane Mara Cesário Pereira.
This study evaluated the epidemiological behavior of the hepatitis A in Paraná state and compared the costs of the disease and the vaccination. This is an epidemiological descriptive study including a pharmacoeconomy analysis. We collected information in the national database reported cases (SINAN), in the mortality information system (SIM) and in the hospital information system (AIH) among 2000/2003 (Paraná State Public Health Department). We estimated the probability of one cohort of children to acquire hepatitis A during their lifetime and the costs with their treatment. We compared those costs with the cost of vaccinating the children. 14,682 hepatitis A cases were registered during the period studied, and 12,102 (82.4%) occurred in the 0-15 years-old...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis A; Vaccine; Epidemiology; Cost-benefit.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400003

Hepatitis B in healthcare workers: prevalence, vaccination and relation to occupational factors
Provedor de dados: 55
Autores: Ciorlia,Luiz A.S.; Zanetta,Dirce M.T.
The prevalence of hepatitis B virus (HBV) in healthcare workers (HCW) in Brazilian university hospitals is high. However, vaccination of these workers and relations with occupational factors are not well documented. A prospective study was made of 1,433 HCW and 872 administrative employees of the Hospital de Base (HB), São José do Rio Preto, SP, Brazil, and 2,583 blood donor candidates from the Hospital Blood Bank. HCW were observed from January 1994 to December 1999. Data were obtained from exams made when a worker entered hospital service, periodically and after work-related injuries. Serological reactions were analyzed in HCW who received HBV vaccine. Occupational and non-occupational information was obtained through a questionnaire. The prevalence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Healthcare workers; Prevalence; Vaccination; Occupational injuries.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500005

Hepatitis B viremia in HIV-coinfected individuals under antiretroviral therapy
Provedor de dados: 55
Autores: Weissmann,Leonardo; Picone,Camila de Melo; Gouvêa,Michele Soares Gomes; Ferreira,Paulo Roberto Abrão; Viana,Mônica Salum Valverde Borsoi; Pinho,João Renato Rebello; Cassenote,Alex Jones Flores; Segurado,Aluísio Cotrim.
ABSTRACT  Background: Antiretroviral therapy (ART) has decreased AIDS incidence and mortality, rendering comorbidities, such as hepatitis B more relevant for people living with human immunodeficiency virus (HIV). Since antiretroviral drugs may also inhibit hepatitis B virus (HBV) replication, analyzing the impact of ART on management of hepatitis B in this population is important.  Objective: To assess HBV viremia among HIV/HBV coinfected individuals on ART and its associated factors.  Method: For this cross-sectional study, HIV/HBV-coinfected individuals, aged over 18 years, who were on ART for over six months and receiving care at an outpatient clinic in São Paulo were recruited. Sociodemographic characteristics, information about viral exposure,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV infections Hepatitis B Coinfection Antiretroviral agents Viremia DNA; Viral.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600441

Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels
Provedor de dados: 55
Autores: Shi,Ming; Zhang,Yong; Zhang,Jing; Liu,Wei; Xing,Lu.
Hepatitis B virus (HBV) genotype and precore and basal core promoter (BCP) mutants in the patients with persistently normal alanine aminotransferase (ALT) and low serum HBV-DNA levels are unclear. The aim of this study was to determine HBV genotypes, precore and BCP mutations, and their association with chronic hepatitis and liver fibrosis in HBV-infected patients with persistently normal ALT, and low serum HBV-DNA levels in northeast China. Patients (n = 89) with normal ALT and serum HBV-DNA levels below 20000 IU/mL but detectable with real-time PCR were included in this study. HBV genotypes were determined by real-time PCR. The precore and BCP mutations were detected by sequencing. All the patients had biopsy results. Of the 89 patients, 11 (12.4%) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Genotype; Mutation; Alanine transaminase.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100009

Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia
Provedor de dados: 55
Autores: Asaad,Ahmed Morad; Al-Ayed,Mohamed Saeed Zayed; Aleraky,Mohamed; Qureshi,Mohamed Ansar.
ABSTRACTThe distribution of hepatitis B virus genotypes in Saudi Arabia is largely unknown. To the best of our knowledge there are no data available about HBV genotypes in southwestern region of the country. This study aimed to determine the epidemiologic distribution of hepatitis B virus genotypes in chronic hepatitis B patients in southwestern region, and to verify possible correlations between these genotypes and the clinical symptoms. A total of 160 patients with chronic hepatitis B infection were enrolled in this study. Sera were tested for liver function tests, hepatitis B virus markers and DNA load by standard procedures. HBV genotyping was performed by 2-tube nested PCR for determination of six genotypes (A-F). Genotype D was the most common, found...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis B; HBV genotypes; Genotype D; Najran.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500525

Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions
Provedor de dados: 55
Autores: Eloy,Alba Maria Xavier; Moreira,Regina Célia; Lemos,Marcílio Figueiredo; Silva,Jéfferson Luis de Almeida; Coêlho,Maria Rosângela Cunha Duarte.
The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients. Eighty-three asymptomatic individuals, three with acute hepatitis B and 33 with chronic hepatitis B referred to viral hepatitis centers in the State of Alagoas, Brazil were analyzed according to their viral load, HBeAg/anti-HBe profile and alanine aminotransferase serum level. The genotypes identified were: A (92.5%), C (5%), D (1.25%) and F (1.25%). The precore mutation was detected in 3.8% of sequences and basal core promoter mutation in 52.4%. These were identified in 45.45% of the asymptomatic individuals and 54.55% of the patients with chronic...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Genotypes; HBV mutation; Alagoas; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600013

Hepatitis B virus infection among institutionalized mentally ill patients in Brazil
Provedor de dados: 55
Autores: Moraes,Tatiane Cinquini; Fiaccadori,Fabíola Souza; Souza,Menira; Almeida,Tâmera Nunes Vieira; Cunha,Marielton dos Passos; Castro,Ítalo de Araújo; Cardoso,Divina das Dôres de Paula.
ABSTRACT  OBJECTIVES:  The main objective was to evaluate HBV infection and occult HBV infection (OBI) cases in mentally ill patients based on serological and molecular profiles.  MATERIAL AND METHODS:  Serum samples of 333 long-stay mentally ill patients were tested for the prevalence of HBV markers by serological (ELISA) and molecular (PCR) assays. The PCR products were sequenced to determine viral genotypes.  RESULTS:  It was observed a global prevalence of 12.9% (43/333) for HBV infection markers, considering HBsAg and/or anti-HBc positivity. Fourteen samples tested positive for anti-HBs alone. All samples positive (n= 57) for any HBV serological markers were tested for HBV-DNA and six were positive: HBsAg/anti-HBc (n = 1), anti-HBc/anti-HBs (n = 1),...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis B virus; Occult infection; Prevalence; Mental illness.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600643

Hepatitis B virus reactivation after treatment for hepatitis C in hemodialysis patients with HBV/HCV coinfection
Provedor de dados: 55
Autores: Wahle,Raul Carlos; Perez,Renata Mello; Pereira,Patrícia Fucuta; Oliveira,Elze Maria Gomes; Emori,Christini Takemi; Uehara,Silvia Naomi de Oliveira; Silva,Ivonete Sandra de Souza; Silva,Antônio Eduardo Benedito; Ferraz,Maria Lucia Gomes.
ABSTRACTIn coinfected HBV/HCV patients, HBV replication is usually suppressed by HCV over the time. No study to date has evaluated the HBV viremia in long-term follow-up after HCV treatment in hemodialysis patients with HBV/HCV coinfection. This study aimed to assess the evolution of HBV viremia after HCV treatment in this special population. Ten hemodialysis patients with HBV/HCV coinfection with dominant HCV infection (HBV lower than 2000 IU/mL) and significant fibrosis were treated with interferon-alpha 3 MU 3×/week for 12 months and could be followed for at least 36 months after HCV treatment. Six cases of HBV reactivation (60%) during follow-up were observed and 5/6 had been successfully treated for HCV. Patients with HBV reactivation received...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Coinfection HBV/HCV; Reactivation HBV; Hemodialysis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500533

Hepatitis C: a critical analysis of therapeutic response predictors
Provedor de dados: 55
Autores: Focaccia,R.; Siciliano,R.F.; Santos,E.D.B.; Boccardo,E.; Conceição,O.J.G.; Barbosa,U.O.; Galante,V.C.
Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, including serum alanine aminotransferase (ALT) normalization, viral load reduction and improvement of hepatic histology.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ALT normalization; Hepatitis C; Viral load reduction.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200003

Hepatitis C and hemodialysis: a review
Provedor de dados: 55
Autores: Moreira,Regina Célia; Lemos,Marcilio Figueiredo; Longui,Carlos Alberto; Granato,Celso.
Hepatitis C is a serious public health problem throughout the world; chronic renal patients are highly exposed to this infection. This could be due to a failure to identify carriers of this disease or because of a lack of truly effective biosafety measures implemented in the dialysis units. Molecular biology techniques have allowed for the understanding of this virus in detail, including its replication mechanisms. Epidemiological studies have been made throughout the world, with the goal of determining the dissemination dynamics of this agent, in addition to examining the predominance of the different genotypes, and the possible mutants that are involved. Many questions must still be answered concerning infection by Hepatitis C virus (HCV); this is...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C (HCV); Hemodialysis.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400001

Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil
Provedor de dados: 55
Autores: Costa,Luce Marina Freires Corrêa da; Mussi,Aparecida Duarte Hg; Brianeze,Marylina Rodrigues; Souto,Francisco José Dutra.
In order to assess the importance of HCV infection as a possible risk factor for type 2 diabetes mellitus, a case-control study was conducted, comparing the prevalence of HCV infection among diabetic and non-diabetic patients. Diabetic outpatients attending to a University Hospital in Central-West Brazil were evaluated between April and October 2005. A control group composed by patients from the same institution was matched by gender and age. Candidates to control group were included only if fasting glucose measures were under 100 mg/dL. Diabetics and controls had blood samples taken in order to test for antibodies against HCV (anti-HCV) by enzyme-immunoassay. Polymerase chain reaction and immunoblot were performed to confirm the anti-HCV status. Each...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Type 2 diabetes mellitus; Case control study; Risk factors; Hepatitis C virus; Epidemiology.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100007

Hepatitis C disease burden and strategies for elimination by 2030 in Brazil. A mathematical modeling approach
Provedor de dados: 55
Autores: Benzaken,Adele Schwartz; Girade,Renato; Catapan,Elisa; Pereira,Gerson Fernando Mendes; Almeida,Elton Carlos de; Vivaldini,Simone; Fernandes,Neide; Razavi,Homie; Schmelzer,Jonathan; Ferraz,Maria Lucia; Ferreira,Paulo Roberto Abrão; Pessoa,Mario Guimarães; Martinelli,Ana; Souto,Francisco José Dutra; Walsh,Nick; Mendes-Correa,Maria Cassia.
ABSTRACT  Introduction and aim: Hepatitis C is a key challenge to public health in Brazil. The objective of this paper was to describe the Brazilian strategy for hepatitis C to meet the 2030 elimination goal proposed by World Health Organization (WHO).  Methods: A mathematical modeling approach was used to estimate the current HCV-infected Brazilian population, and to evaluate the relative costs of two different scenarios to address HCV disease burden in Brazil: (1) if no further changes are made to the HCV treatment program in Brazil; (2) where the WHO targets for 2030 elimination are met through diagnosis and treatment efforts peaking before 2024.  Results: An anti-HCV prevalence of 0.53% was calculated for the total population. It was estimated that the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Hepatitis C elimination; Hepatitis C disease burden; Brazil.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300182

Hepatitis C: genotyping
Provedor de dados: 55
Autores: Cavalheiro,Norma de Paula.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700009

Hepatitis C in hemodialysis: the contribution of injection drug use
Provedor de dados: 55
Autores: Galperim,Bruno; Mattos,Angelo A; Stein,Airton T; Schneider,Nuttiane C; Buriol,André; Fonseca,André; Lunge,Vagner; Ikuta,Nilo.
BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV),...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C virus; Hemodialysis; Injection drug use; Risk factors.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020

Hepatitis C prevalence among men who have sex with men in Central Brazil
Provedor de dados: 55
Autores: Andrade,Andreia Alves de; Silva,Ágabo Macêdo da Costa e; Carneiro,Megmar Aparecida dos Santos; Teles,Sheila Araújo; Martins,Regina Maria Bringel.
Abstract To assess the prevalence of hepatitis C virus infection among men who have sex with men (MSM) in Central Brazil, a cross-sectional study was conducted in the City of Goiânia, Central Brazil, using Respondent-Driven Sampling (RDS). All serum samples were tested for anti-HCV and also for alanine aminotransferase (ALT). Anti-HCV positive samples and/or those with elevated ALT were tested for HCV RNA and genotyped. Of the 522 participants, four were found to be anti-HCV positive, and one was also HCV RNA positive (active HCV infection). Elevated ALT was found in 14 individuals. Of these, one showed evidence of acute HCV infection (HCV RNA positive and anti-HCV negative). Therefore, five MSM were positive for either anti-HCV and/or HCV RNA, giving a...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C virus; Men who have sex with men; Prevalence; Brazil.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400271

Hepatitis C risk factor for patients submitted to dialysis
Provedor de dados: 55
Autores: Baldessar,Maria Zélia; Bettiol,Jane; Foppa,Fabrício; Oliveira,Lúcia Helena das Chagas.
This article reports the results of the research which has evaluated the prevalence and factors associated to the presence of Hepatitis C in patients submitted to dialysis at the Clinica de Doenças Renais (Clinic of Renal Diseases) in Tubarao city (CRDT), Santa Catarina State, Brazil, in the period between January 1st, 2004 to December 31st in the same year. The prevalence of 16.8% of Hepatitis C in the studied population and the time-length of dialysis as significative risk factor have become evident. The non-correlation of seropositivity of the followings factors is also indicated: age, gender, base diseases, infrastructures, the type of clinic machines, the type of dialyser, used membranes, the machine sterilisation and substances for this process as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dialysis; Hepatitis C; Nosocomial infection.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100005

Hepatitis C therapy in 2011: is less more, is more less?
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600002

Hepatitis C treatment before and after liver transplant
Provedor de dados: 55
Autores: Abdala,Edson; Gotardo,Daniela Rosa Magalhães; Bonazzi,Patrícia Rodrigues; Bacchella,Telésforo.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700019

Hepatitis C treatment: shorter and better?
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de; Courtouké,Cláudia; Barone,Antonio Alci.
Herein, we present a synthesis of two publications that evaluate an abbreviated therapeutic approach to treating chronic hepatitis C virus (HCV) infection. Based on those publications, we discuss the use of the early virologic response (EVR) as a tool for the optimized management of patients under treatment, as well as reviewing concepts of HCV viral kinetics. The fourth-week EVR, characterized by HCV RNA dropping to undetectable levels, allows individuals infected with HCV genotype 1 and presenting low baseline viral loads to be treated with the combination of pegylated interferon and ribavirin for 24 weeks, whereas individuals infected with HCV genotypes 2 or 3 can be treated for only 12 weeks. Therefore, by adopting abbreviated treatment regimens...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Interferon; Viral kinetics.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100026

Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil
Provedor de dados: 55
Autores: Alves,Fabiana Aparecida; Campos,Karoline Rodrigues; Lemos,Marcílio Figueiredo; Moreira,Regina Célia; Caterino-de-Araujo,Adele.
ABSTRACT Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from São Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected (n = 548), HCV/HIV-1- (n = 41), HCV/HTLV-1- (n = 16), HCV/HTLV-2- (n = 8), HCV/HIV/HTLV-1- (n = 4), and HCV/HIV/HTLV-2-co-infected (n = 5) patients, and results were compared among the groups and according to sex. The median HCV load in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; HIV-1; HTLV-1: HTLV-2; Co-infection; Viral load.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200123

Hepatitis C: virological aspects and practical implications
Provedor de dados: 55
Autores: Barone,Antonio Alci.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700005

Hepatitis C virus core antigen assay: can we think beyond convention in resource limited settings?
Provedor de dados: 55
Autores: Chakravarti,Anita; Chauhan,Mayank S.; Dogra,Gaurav; Banerjee,Sayantan.
ABSTRACT Hepatitis C virus infects over 15 million patients from India and 2.86 million from Brazil. Detection of anti-hepatitis C virus antibodies has limited sensitivity during acute phase: the pre-seroconversion window period. Hepatitis C virus-RNA detection techniques are used to overcome this shortfall, but are costly and unavailable widely in developing countries. Estimation of hepatitis C virus core-antigen, a protein with highly conserved sequence, by enzyme-immunoassays is an economic and simpler alternative to RNA detection. This study was conducted in Delhi, involving 300 acute and chronic liver disease patients, tested for anti-hepatitis C virus 3rd-generation ELISA, hepatitis C virus core-antigen-ELISA and hepatitis C virus-RNA reverse...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C; Diagnosis; Core antigen; HCVcAg.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300010

Hepatitis C virus detection in the semen of infected patients
Provedor de dados: 55
Autores: Cavalheiro,Norma de Paula; Santos,Ana Carolina de Oliveira; Melo,Carlos Eduardo; Morimitsu,Suzana Rie; Barone,Antonio Alci.
Though HCV infection is a serious public health problem, some aspects of its biology are still not well understood, such as its transmission through seminal fluid and sexual transmission. We looked for HCV in the semen of infected patients. Thirteen patients were included. Semen fractions (seminal plasma, leukocytes and spermatozoa) were separated with 45% and 90% Percoll gradients. The HCV-RNA in blood and semen fractions was extracted using the same protocol (AMPLICOR Roche) and was detected using the qualitative Roche Amplicor test and by agarose gel electrophoresis, with ethidium bromide staining. The mean age of the patients was 40.7 years. Risk factors for the acquisition of HCV included injectable and inhaled drug use in six (42.8%), blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; PCR; Sexual transmission; Semen.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500003

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Marchand,Chloe Le; Bahia,Fabianna; Page,Kimberly; Brites,Carlos.
ABSTRACTBACKGROUND: While 20-40% of patients with hepatitis C virus (HCV) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. HCV, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus 1 and 2 (HTLV-1/2) coinfection occurs due to shared routes of transmission and is prevalent in Brazil.OBJECTIVES:To compare the proportion of patients who have spontaneously cleared HCV in patients with HCV monoinfection to patients coinfected by HCV/HIV, or HCV/HIV/HTLV-1.METHODS:Using medical records from two clinics in Salvador, Brazil, including demographic data and serological markers of HCV, HIV and HTLV-I/II, cross-sectional data was obtained from 197 patients. Patients who were anti-HCV positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; HIV; Hepatitis C; Brazil; Spontaneous HCV clearance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500486

Hepatitis C virus: molecular and epidemiological evidence of male-to-female transmission
Provedor de dados: 55
Autores: Cavalheiro,Norma de Paula; de La Rosa,Abel; Elagin,Slava; Tengan,Fatima Mitiko; Barone,Antonio Alci.
INTRODUCTION: There is general consensus that hepatitis C virus is efficiently transmitted by the parenteral route, whereas data on viral transmission by sexual or non-sexual intrafamilial contact are conflicting. OBJECTIVE AND METHOD: The aim of this study was to investigate the transmission of hepatitis C virus in nine heterosexual couples. RESULT: The mean age of the couples was 43.7 years. When interviewed, all of the women denied the presence of risk factors for acquisition of the infection, whereas the cause of infection in the nine husbands could be attributed to blood transfusions in two of them (22.2%), use of intravenous and inhaled drugs in six (66.7%), acupuncture in one (11.1%), and tattooing in one (11.1%). All men and none of the women...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually transmitted diseases; Phylogeny; Hepatitis C.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500001

Hepatitis C virus perinatal transmission
Provedor de dados: 55
Autores: Oliveira,Umbeliana Barbosa de.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700004

Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia
Provedor de dados: 55
Autores: Abdelmawla,Doaa; Moemen,Dalia; Darwish,Ahmad; Mowafy,Wafaa.
ABSTRACT Hepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. thalassemic patients with increased risk of morbidity and mortality. In addition there is possibility of HEV transmission through blood transfusion. Therefore, the present study aimed to investigate the seroprevalence and risk factors of HEV infection in β-thalassemic children.  Methods: This cross-sectional study was conducted on 140 Egyptian children suffering from β-thalassemia, attending the hematology outpatient clinic from April to October 2016. Serum samples from patients were collected and anti-HEV antibodies; Immunoglobulin G (IgG) and Immunoglobulin M (IgM)were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus (HEV); Prevalence; Thalassemia; Transfusion.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100040

Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil
Provedor de dados: 55
Autores: Passos-Castilho,Ana Maria; de Sena,Anne; Domingues,Ana Lucia Coutinho; Lopes-Neto,Edmundo Pessoa; Medeiros,Tibério Batista; Granato,Celso Francisco Hernandez; Ferraz,Maria Lúcia.
Abstract  Background Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wantai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; Epidemiology; Hepatitis E virus; Schistosomiasis; Seroprevalence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300007

Hepatitis in Dengue Shock Syndrome
Provedor de dados: 55
Autores: Souza,Luiz José de; Carneiro,Helder Gonçalves; Souto Filho,João Tadeu Damian; Souza,Thiago Ferreira de; Côrtes,Vitor Azevedo; Gicovate Neto,Carlos; Bastos,Diogo Assed; Siqueira,Edno Wallace da Silva.
Dengue fever is the most frequent arbovirus disease in the world and the most important one in terms of morbidity and mortality. Atypical manifestations of dengue have become commonplace during the last few years, including hepatic damage, which manifests mainly by pain in the right hypochondrium and an increase in the levels of aminotransferases. We describe a case of acute hepatitis in a patient with Dengue Shock Syndrome Grade III. We analyzed the clinical and laboratory aspects of this atypical complication of dengue as well as the differential diagnoses.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acute hepatitis; Dengue; Dengue hemorrhagic fever.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600010

Hepatocellular carcinoma in patients with B and C virus hepatitis without cirrhosis
Provedor de dados: 55
Autores: Carvalho,Kellyane Santana Dias; Cotrim,Helma Pinchemel; Fonseca Junior,Luciano Espinheira; Moreira,Valéria; Sirqueira,Érika.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300367

Hepato-pulmonary amebiasis: a case report
Provedor de dados: 55
Autores: Shenoy,Vishnu Prasad; Vishwanath,Shashidhar; Indira,Bairy; Rodrigues,G.
Infections with Entamoeba histolytica are seen worldwide and are more prevalent in the tropics. About 90% of infections are asymptomatic, and the remaining 10% produce a spectrum of clinical syndromes, ranging from dysentery to abscesses of the liver or other organs. Extra-intestinal infection by E. histolytica most often involves liver. Pleuro-pulmonary involvement, seen as the second most common extra-intestinal pattern of infection, is frequently associated with amebic liver abscess. Pulmonary amebiasis occurs in about 2-3% of patients with invasive amebiasis. We report herein the case of a 45-year-old male presenting with hepato-pulmonary amebiasis. The diagnosis was established from direct examination of sputum, in which trophozoites of E. histolytica...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Entamoeba histolytica; Liver abscess; Microscopy; Pulmonary involvement.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400010

Hepatotropic viruses in the Brazilian Amazon: a health threat
Provedor de dados: 55
Autores: Paraná,Raymundo; Vitvitski,Ludmila; Pereira,Joao Eduardo.
Viral Hepatitis B, C and D are a serious public health problem in Brazil and other South American countries, mainly in the Amazonian region. Despite the paucity of clinical and epidemiological studies, a high prevalence of Hepatitis viruses has often been described in this area. Genotype F of Hepatitis B and Genotype III of Hepatitis D have been found to be quite prevalent in this area and preliminary studies have implicated both genotypes in carcinogenesis and peculiar pathogenic liver mechanisms. Initial epidemiological studies have further demonstrated a high prevalence of Hepatitis C in the western Brazilian Amazon. The geographic, cultural, ethnic and environmental aspects of this region may favor hepatotropic virus dissemination, as well as rendering...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; Amazonian; Hepatitis viruses; South America.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300017

Herpes simplex type 2 pneumonia
Provedor de dados: 55
Autores: Calore,Edenilson Eduardo.
Extensive reviews of pulmonary infections in AIDS have reported few herpetic infections. Generally these infections are due to Herpes simplex type 1. Pneumonia due to herpes type 2 is extremely rare. We describe a 40 year-old HIV positive woman who complained of fever, cough and dyspnea for seven years. She had signs of heart failure and the appearance of her genital vesicles was highly suggestive of genital herpes. Echocardiography showed marked pulmonary hypertension, right ventricular hypertrophy and tricuspid insufficiency. After a few days of hospitalization she was treated with Aciclovir and later with Ganciclovir. An open pulmonary biopsy revealed an interstitial inflammation, localized in the alveolar walls. Some pulmonary arteries had widened...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Herpes pneumonia; AIDS; Opportunistic infections; Pulmonary hypertension; Herpes simplex.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600006

Herpes simplex virus ophthalmic disease induced using two different methods of mice inoculation
Provedor de dados: 55
Autores: Pereira,Sílvia Regina Ferreira Gonçalves; Guimarães,Maria Angélica A. M.; V. Neto,Leonardo; Segenreich,Daniel; Varella,Rafael Brandão; Chagas,Vera Lucia Antunes; Câmara,Fernando Portela.
Two different procedures for inoculation of HSV on corneas of BALB/c mice were evaluated. The first was by the use of HSV suspensions directly on the corneas and the other was after corneal scarification. Animals by this later method presented greater morbidity and mortality than those of first group, suggesting that inoculation of HSV without scarification of the cornea should be the method of choice for the study of HSV ophthalmic infection. This model showed also be an efficient experimental system to testing antiviral drugs.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Herpes simplex virus; Ophthalmic disease; Non-traumatic and traumatic inoculation; Murine model.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400004

Heterogeneous distribution of HCV genotypes and growing menace of mixed HCV infection in blood recipients in Khyber Pakhtunkhwa
Provedor de dados: 55
Autores: Attaullah,Sobia; Khan,Sanaullah; Zahid,Muhammad.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400489

Heterogeneous resistance to vancomycin and teicoplanin among Staphylococcus spp. isolated from bacteremia
Provedor de dados: 55
Autores: Nunes,Ana Paula Ferreira; Schuenck,Ricardo Pinto; Bastos,Carla Callegário Reis; Magnanini,Mônica Maria F.; Long,Jacinta B.; Iorio,Natália Lopes Pontes; Santos,Kátia Regina Netto dos.
This study evaluated the BHIA screening method with 4 or 6 mug/mL of vancomycin to detect glycopeptides heteroresistant staphylococci strains isolated from bacteremia. A total of 213 staphylococci strains were isolated from 106 patients between October/2001 and November/2002 in a tertiary hospital in Rio de Janeiro city. Fifty-seven (53.8%) patients presented Staphylococcus aureus, while coagulase-negative staphylococci (CNS) were isolated from 49 (46.2%). Resistance rates for oxacillin of 26.3% and 81.6% were found for the staphylococci isolates, respectively. Thirteen CNS isolated from nine (8.5%) patients grew on agar screening with 4 mug/mL of vancomycin and showed heterogeneous profiles of resistance for vancomycin and teicoplanin by the population...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococci; Vancomycin and teicoplanin heteroresistance; Population analysis profile; Vancomycin agar screen.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300009

High degree of concordance between ﬂow cytometry and geno2pheno methods for HIV-1 tropism determination in proviral DNA
Provedor de dados: 55
Autores: Torres,Alex José Leite; Brígido,Luis Fernando de Macedo; Abrahão,Marcos Herculano Nunes; Angelo,Ana Luiza Dias; Ferreira,Gilcivaldo de Jesus; Coelho,Luana Portes; Ferreira,João Leandro; Jorge,Célia Regina Mayoral Pedroso; Martins Netto,Eduardo; Brites,Carlos.
Use of CCR5 antagonists requires previous viral tropism determination. The available methods have high cost, are time-consuming, or require highly trained personnel, and sophisticated equipment. We compared a ﬂow cytometry-based tropism assay with geno2pheno method to determine HIV-1 tropism in AIDS patients, in Bahia, Brazil. We tested peripheral blood mononuclear cells of 102 AIDS patients under antiretroviral therapy by using a cytometry-based tropism assay and geno2pheno assay. Cellular membrane receptors were identiﬁed by using CXCR4, CCR5 and CD4 monoclonal antibodies, while detection of cytoplasmic mRNAs for gag and pol HIV regions was achieved by using a labeled probe. Genotypic identiﬁcation of X4 and R5 tropic viruses was attempted by geno2pheno...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Tropism; Flow cytometry; Geno2pheno.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200163

High frequency of colonization and absence of identifiable risk factors for methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units in Brazil
Provedor de dados: 55
Autores: Korn,Gustavo P.; Martino,Marinês D. V.; Mimica,Igor M.; Mimica,Lycia J.; Chiavone,Paulo A.; Musolino,Luiz R. de S.
Colonization of hospitalized patients with methicillin-resistant Staphylococcus aureus (MRSA) is of increasing concern. To evaluate this problem in Intensive Care Units (ICUs) in Brazil, we studied 100 patients admitted to two ICUs from April to June, 1997. Of the 100 patients, 70 were male, 53 were age 60 years or older, 55 were previously hospitalized, 78 were transferred to the ICU from other hospital units, 49 had received antibiotic therapy, and 66 had undergone recent surgery. Nasal and axillary swab cultures were obtained on admission and every 48 hours thereafter until discharge. MRSA were identified by plating any cultured S. aureus on Mueller-Hinton agar containing 6mug/ml of oxacillin. At the time of admission, 46 (46%) of the patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Methicillin resistance; Hospital infections.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100001

High frequency of human papillomavirus type 53 in oral cavity of asymptomatic HIV-infected people
Provedor de dados: 55
Autores: Silva,Carolina Oliveira; Santos,Larissa Silva; Pereira,Olga Maria Diniz; Azevedo,Kátia Martins Lopes; Oliveira,Ledy Horto Santos.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100111

High HIV infection prevalence in a group of men who have sex with men
Provedor de dados: 55
Autores: Torres,Raquel Maria Cardoso; Cruz,Marly Marques da; Périssé,André Reynaldo Santos; Pires,Denise Ribeiro Franqueira.
ABSTRACT Brazil is characterized by a concentrated AIDS epidemic, it has a prevalence of less than 1% in the general population. However, there are higher rates in specific populations, especially in men who have sex with men. The study's aim was to analyze the association between sociodemographic characteristics, sexual practices, sexual behaviors and the HIV infection in a group of men who have sex with men. Secondary data was collected between June 2014 and September 2015 in a research of cross-sectional design in the city of Rio de Janeiro, Brazil. Volunteers answered an online computerized questionnaire and took HIV test. Chi-squared distribution and multiple logistic regression was used. There were 341 participants. Most of them were racially mixed,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired Immunodeficiency Syndrome; Male homosexuality; Bisexuality; Sexual behavior; HIV serosorting.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600596

High HPV prevalence and need for ancillary care
Provedor de dados: 55
Autores: Brown,Brandon.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100110

High incidence of tuberculosis in patients treated for hepatitis C chronic infection
Provedor de dados: 55
Autores: de Oliveira Uehara,Silvia Naomi; Emori,Christini Takemi; Perez,Renata Mello; Mendes-Correa,Maria Cassia Jacintho; de Souza Paiva Ferreira,Adalgisa; de Castro Amaral Feldner,Ana Cristina; Silva,Antonio Eduardo Benedito; Filho,Roberto José Carvalho; de Souza e Silva,Ivonete Sandra; Ferraz,Maria Lucia Cardoso Gomes.
Abstract Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during α-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C α-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C; Tuberculosis; Alpha-interferon; Latent tuberculosis infection.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200205

High mortality outbreak of carbapenem-resistant Pseudomonas aeruginosa infection in a Brazilian pediatric oncology hospital
Provedor de dados: 55
Autores: Quiles,Milene Gonçalves; Carlesse,Fabianne; Silva,Maria Aparecida Aguiar da; Mingrone,Roberta Cabral; Fonseca,Juliane Melo; Silva,Dafne Cardoso; Pignatari,Antonio Carlos Campos.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200205

High prevalence and incidence of HIV-1 in a counseling and testing center in the city of Itajaí, Brazil
Provedor de dados: 55
Autores: Grinberg,Gorki; Giron,Leila Bertoni; Knoll,Rosalie Kupka; Galinskas,Juliana; Camargo,Michelle; Arif,Muhammad Shoaib; Samer,Sadia; Janini,Luiz Mario Ramos; Sucupira,Maria Cecilia Araripe; Diaz,Ricardo Sobhie.
ABSTRACT Itajaí is a port city in southern Brazil with one of the highest incidence and mortality rates from AIDS in the country. The prevalence and incidence of HIV infection were investigated in 1085 of 3196 new HIV-1 infection cases evaluated in the counseling and testing center of Itajaí from January 2002 to August 2008. Recent infections were assessed using the BED(tm), and polregion sequencing was performed in 76 samples. The prevalence ranged from 3.08% to 6.17% among women and from 10.26% to 17.36% among men. A total of 17% of infections were classified as recent, with annual incidence varying from 1.6% to 4.8 per 100 patient/year among women and from 2.05% to 8.5 per 100 patient/year among men. Pol sequences were obtained from 38 randomly recent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Recent HIV infection; HIV subtype; Brazil; Transmitted drug resistance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600631

High prevalence of CTX-M-1 group in ESBL-producing enterobacteriaceae infection in intensive care units in southern Chile
Provedor de dados: 55
Autores: Pavez,Mónica; Troncoso,Claudia; Osses,Irma; Salazar,Rodrigo; Illesca,Vijna; Reydet,Patricia; Rodríguez,Claudio; Chahin,Carolina; Concha,Carla; Barrientos,Leticia.
ABSTRACT Enterobacteria-producing extended-spectrum β-lactamases (ESBL) play an important role in healthcare infections, increasing hospitalization time, morbidity and mortality rates. Among several ESBLs that emerge from these pathogens, CTX-M-type enzymes had the most successful global spread in different epidemiological settings. Latin America presents high prevalence of CTX-M-2 in ESBL-producing enterobacterial infections with local emergence of the CTX-M-1 group. However, this high prevalence of the CTX-M-1 group has not yet been reported in Chile. The aim of this study was to identify ESBLs among enterobacteria isolated from clinical samples of critically ill patients from southern Chile. One-hundred thirty seven ESBL-producing bacteria were isolated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL-producing enterobacteria; Intensive care units; CTX-M-1 group.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200102

High prevalence of giardiasis and strongyloidiasis among HIV-infected patients in Bahia, Brazil
Provedor de dados: 55
Autores: Feitosa,Giovana; Bandeira,Antônio C.; Sampaio,Diana P.; Badaró,Roberto; Brites,Carlos.
Diarrhea due to intestinal microbial infections is a frequent manifestation among HIV-infected patients. It has been postulated that HIV-infected patients may have special types of intestinal infections, and that immune activation from such parasites may affect the progression of HIV disease. To evaluate these associations, the frequency of infections was examined in HIV-infected patients in Bahia, Brazil. To determine the potential impact of the presence of intestinal parasitic infections on HIV disease progression, a retrospective study approach was used. The medical charts of 365 HIV-infected patients who had been treated at the AIDS Clinic of the Federal University of Bahia Hospital were reviewed, and the prevalence of parasites was compared with 5,243...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-infected patients; Strongyloidiasis; Giardiasis.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600008

High prevalence of hepatitis C associated with familial history of hepatitis in a small town of south Brazil: efficiency of the rapid test for epidemiological survey
Provedor de dados: 55
Autores: Ivantes,Cláudia Alexandra Pontes; Silva,Danilo; Messias-Reason,Iara.
This report describes a cross-sectional survey on the prevalence of hepatitis C antibodies (anti-HCV) in Tamboara, a small community in the northwest area from Paraná State, south of Brazil with a high rate of accumulated detection for HCV. Eight hundred and sixteen residents (17.87% from all the population), independently of the age and time living in Tamboara were included in this study by an epidemiologic questionnaire and by testing for anti-HCV. The rapid immuno-chromatographic test was applied for detection of HCV antibodies. The anti-HCV prevalence by rapid test was 4.28%. The median age for positive and negative test was 60.49 ± 14.14 and 41.67 ± 20.25, respectively (p &lt; 0.001). By multivariate analysis, only familial history of hepatitis (p =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Epidemiology; Brazil.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500010

High prevalence of hepatitis C infection in a Brazilian prison: identification of risk factors for infection
Provedor de dados: 55
Autores: Guimarães,Thaís; Granato,Celso F. H.; Varella,Drauzio; Ferraz,Maria Lúcia G.; Castelo,Adauto; Kallás,Esper Georges.
Hepatitis C virus (HCV) causes infectious hepatitis worldwide. It is transmitted mainly by blood products and sharing of intravenous paraphernalia during illicit drug use. High prevalence rates have been described among specific groups considered to be at higher risk for HCV infection, including prison inmates. The objectives of this study were: to determine the HCV seroprevalence among inmates of Casa de Detenção de São Paulo; to identify risk factors for HCV infection; and to compare the seroprevalence of HCV to other blood borne or sexually transmitted diseases. From December, 1993, to January, 1994, a total of 779 inmates were interviewed to collect information on sociodemographic status, sexual behavior, and past experience with illicit drugs. Blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Seroprevalence; Prison; Risk factor.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300002

High prevalence of hepatitis E virus antibodies in Sao Paulo, Southeastern Brazil: analysis of a group of blood donors representative of the general population
Provedor de dados: 55
Autores: Passos-Castilho,Ana Maria; Reinaldo,Mônica Renata; Sena,Anne de; Granato,Celso F.H.
Abstract Brazil is a non-endemic country for hepatitis E virus (HEV) infection with seroprevalence from 1% to 4% in blood donors and the general population. However, data on seroprevalence of HEV in the country are still limited. This study evaluated the prevalence of past or present HEV infection in a group of blood donors representative of the general population of the city of Sao Paulo, Southeastern Brazil. Serum samples from 500 blood donors were tested from July to September 2014 by serological and molecular methods. Anti-HEV IgG antibodies were detected in 49 (9.8%) subjects and categorized age groups revealed an age-dependent increase of HEV seroprevalence. Among the anti-HEV IgG positive subjects, only 1 had anti-HEV IgM while none tested positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus; Blood donors; Seroprevalence; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500535

High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007 - 2009
Provedor de dados: 55
Autores: Ghietto,Lucía María; Cámara,Alicia; Zhou,Yumei; Pedranti,Mauro; Ferreyra,Silvia; Frey,Teryl; Cámara,Jorge; Adamo,Maria Pilar.
Human bocavirus (HBoV) is a parvovirus whose association with respiratory disease is currently under investigation. OBJECTIVE: To determine HBoV prevalence in children with lower acute respiratory infection. METHODS: We investigated HBoV in 433 nasopharyngeal aspirates collected in 2007-2009 from children 0 to 5 years old hospitalized with bronchiolitis or pneumonia in Córdoba, Argentina. RESULTS: The general prevalence of HBoV was 21.5% and the positive cases (HBoV+) were more frequent during winter and spring. The mean age of HBoV+ patients was 6.9 months, with 87.1% of the detections corresponding to infants less than 1 year old (among which the prevalence of HBoV was 26.3% in patients &lt; 3 months of age, 22.1% in 3 to 6 months, 25.3% in 6 to 9...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human bocavirus 1; Infant; Bronchiolitis; Pneumonia.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100007

High rate of virologic suppression with darunavir/ritonavir plus optimized background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil
Provedor de dados: 55
Autores: Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir.
OBJECTIVES: To assess the virologic and immunological response of darunavir/ritonavir plus optimized background therapy in highly antiretroviral-experienced HIV-infected patients in Brazil. METHODS: Prospective cohort study carried out in a tertiary center in Sao Paulo, Brazil. Three-class antiretroviral-experienced patients with confirmed virologic failure began darunavir/ritonavir plus optimized background therapy (nucleoside/tide reverse transcriptase inhibitors ± raltegravir ± enfuvirtide ± maraviroc) after performing a genotypic resistance assay. Clinical evaluation and laboratory tests were collected at baseline and at weeks 12, 24, and 48. Multivariate analysis was performed to identify predictors of virologic response at 48 weeks. RESULTS:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Highly active antiretroviral therapy; Darunavir; Acquired immunodeficiency syndrome; Developing countries.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100007

High vertical HIV transmission rate in the Midwest region of Brazil
Provedor de dados: 55
Autores: Matos,Vanessa Terezinha Gubert de; Batista,Fabiani de Morais; Versage,Naiara Valera; Pinto,Clarice Souza; Oliveira,Vanessa Marcon de; Vasconcelos-Pereira,Érica Freire de; Matos,Roberta Barbeta dos Rios de; Fabbro,Márcia Maria Ferrairo Janini Dal; Oliveira,Ana Lúcia Lyrio de.
ABSTRACT  Objectives To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission.  Methods A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants.  Results A total of 218 births of 176 HIV-infected pregnant women were identified during the study period, of which 187 infants were exposed and uninfected, 19 seroconverted, and 12 were still inconclusive in July 2015. Therefore, the overall vertical HIV transmission rate in the period was 8.7%. Most (71.6%) of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vertical transmission; HIV; Disease prevention; Antiretroviral therapy; Prenatal follow-up; Health services; Social environment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300177

High-risk human papillomavirus and cervical lesions among women living with HIV/AIDS in Brazilian Amazon, Brazil
Provedor de dados: 55
Autores: Silva,Leila da; Miranda,Angélica; Batalha,Rosieny; Ferreira,Luiz; Santos,Mayara; Talhari,Sinésio.
ABSTRACT  OBJECTIVE:  The goal of this study was to determine the prevalence of human papillomavirus infection infection and cervical lesions and its associated factors among HIV infected women attending an AIDS clinic in Amazonas state, Brazil.  METHODS:  Cross-sectional study. Women attending an AIDS clinic in the city of Manaus between March and December 2011 for gynecological examination were invited to participate. Enrolled patients answered a standardized interview including demographical, behavioral, and clinical data. Additionally, patients underwent a gynecological evaluation with collection of cervical samples for cytological analysis and high-risk human papillomavirus infection hybrid capture. A blood sample was also obtained to determine CD4...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; HIV; Cervical cancer; Brazilian Amazon.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600557

Histological response study of chronic viral hepatitis C patients treated with interferon alone or combined with ribavirin
Provedor de dados: 55
Autores: Prado,Kleber; Patzina,Rosely; Bergamaschi,Denise; Focaccia,Roberto.
Chronic hepatitis C is often a progressive, fibrotic disease that can lead to cirrhosis and other complications. The recommended therapy is a combination of interferon and ribavirin. Besides its antiviral action, interferon is considered to have antifibrotic activity. We examined the outcome of hepatic fibrosis and inflammation in chronic hepatitis C patients who were non-responders to interferon. We made a case series, retrospective study, based on revision of medical records and reassessment of liver biopsies. For inclusion, patients should have been treated with interferon alone or combined with ribavirin, with no virological response (non responders and relapsers) and had a liver biopsy before and after treatment. Histological evaluation included:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Fibrosis; Interferon-alfa; Ribavirin; Treatment result.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500004

Histoplasmosis diagnosed after arthroscopy of the knee: case report
Provedor de dados: 55
Autores: Falster,Lorenzo; Marin,Maurício B.; Gomes,João Luiz Ellera.
ABSTRACTFungal arthritis is a rare complication of arthroscopic surgeries, but its possibility should always be considered due its deleterious effects on any joint. Infection caused by the fungus Histoplasma capsulatum is the most common cause of respiratory tract infections by fungi, meanwhile histoplasmosis arthritis is more rare than all other fungal infections. However, their atypical forms of arthritis and the importance of early diagnosis and treatment cannot be over-emphasized. Herein we report a case of knee monoarthritis in an immunocompetent patient with histoplasmosis arthritis following an arthroscopic meniscetomy, diagnosed by synovial biopsy and culture performed during a second arthroscopic procedure. The joint was debrided in this second...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Histoplasmosis; Knee; Arthritis; Fungal.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500546

HIV associated lymphomas: problems with the histopathologic classification
Provedor de dados: 55
Autores: Barbosa,Helenemarie Schaer.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500021

HIV frequency among female sex workers in Imbituba, Santa Catarina, Brazil
Provedor de dados: 55
Autores: Trevisol,Fabiana Schuelter; Silva,Marcos Vinicius da.
We examined HIV frequency and probable risk factors among female sex workers in the port city of Imbituba, Southern Brazil. From December 2003 through February 2004, 90 female sex workers were interviewed in order to investigate demographic, socioeconomic and behavioral variables related to HIV infection. A blood sample of each woman was also collected to test for HIV antibodies. Six (6.7%) of the sex workers were HIV-positive; the significantly-correlated risk factors were the daily number of clients (p = 0.008), the use of inhaled illicit drugs by the sex workers (P = 0.053) and by their clients (p = 0.005), and the lack of condom use in sexual relations (p = 0.015). The HIV infection rate in these sex workers was higher than that in the general...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Prostitution; Risk behavior.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600008

HIV prevalence among blood donors in a blood bank in Curitiba (Brazil)
Provedor de dados: 55
Autores: Andrade Neto,José Luiz; Pintarelli,Vitor Last; Felchner,Paulo Cesar Zimmermann; Morais,Rodrigo Leite de; Nishimoto,Fabíola Lie.
There still is no cure for the acquired immunodeficiency syndrome (AIDS). Its etiologic agent is the human immunodeficiency virus (HIV), and transmission occurs through sexual relationships, contacts with blood, and vertically (mother to child). In this study, we sought to determine the prevalence of HIV among blood donors at a blood bank in Curitiba. We studied 213,666 blood donations made from March 1, 1992, to April 25, 1999. Each potential blood donor first answered a questionnaire, submitted to a clinical examination, and filled out a self-exclusion card. Blood was collected and analyzed only from the candidates approved by the first two criteria. Two tests were used to detect HIV: ELISA for screening, and Western-Blot for confirmation. The results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Blood donor; HIV.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100003

HIV subtype, epidemiological and mutational correlations in patients from Paraná, Brazil
Provedor de dados: 55
Autores: Silva,Monica Maria Gomes da; Telles,Flavio Queiroz; Cunha,Clovis Arns da; Rhame,Frank S.
OBJECTIVE: Analyze patients with HIV infection from Curitiba, Paraná, their epidemiological characteristics and HIV RAM. METHODS: Patients regularly followed in an ID Clinic had their medical data evaluated and cases of virological failure were analyzed with genotypic report. RESULTS: Patients with complete medical charts were selected (n = 191). Demographic and clinical characteristics were compared. One hundred thirty two patients presented with subtype B infection (69.1%), 41 subtype C (21.5%), 10 subtype F (5.2%), 7 BF (3.7%) and 1 CF (0.5%). Patients with subtype B infection had been diagnosed earlier than patients with subtype non-B. Also, subtype B infection was more frequent in men who have sex with men, while non-B subtypes occurred more...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Aids; Subtypes; Subtype B; Subtype non-B; Genetic diversity; Antiretroviral; Brazil.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500012

HIV testing and HIV knowledge among men who have sex with men in Natal, Northeast Brazil
Provedor de dados: 55
Autores: Bay,Monica Baumgardt; Freitas,Marise Reis de; Lucas,Marcia Cavalcante Vinhas; Souza,Elizabeth Cristina Fagundes de; Roncalli,Angelo Giuseppe.
ABSTRACT  Background: Men who have sex with men (MSM) account for the highest prevalence of HIV in Brazil. HIV testing allows to implement preventive measures, reduces transmission, morbidity, and mortality.  Methods: We conducted a cross-sectional study to evaluate HIV testing during lifetime, factors associated with the decision to test, knowledge about HIV transmission, and use of condoms between MSM from the city of Natal, northeast Brazil.  Results: Out of 99 participants, 62.6% had been tested for HIV during lifetime, 46.2% in the last year. The most frequent reported reason to be tested for HIV infection was curiosity (35.5%). Correct knowledge about HIV was observed in only 9.2% of participants. In multivariate analysis, age (PR 0.95; 95%CI,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV testing; Men who have sex with men (MSM); HIV knowledge.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100002

HIV testing during pregnancy: use of secondary data to estimate 2006 test coverage and prevalence in Brazil
Provedor de dados: 55
Autores: Szwarcwald,Célia Landmann; Barbosa Júnior,Aristides; Souza-Júnior,Paulo Roberto Borges de; Lemos,Kátia Regina Valente de; Frias,Paulo Germano de; Luhm,Karin Regina; Holcman,Marcia Moreira; Esteves,Maria Angela Pires.
This paper describes a methodological proposal based on secondary data and the main results of the HIV-Sentinel Study among childbearing women, carried out in Brazil during 2006. A probabilistic sample of childbearing women was selected in two stages. In the first stage, 150 health establishments were selected, stratified by municipality size (&lt;50,000; 50,000-399,999; 400,000+). In the second stage, 100-120 women were selected systematically. Data collection was based on HIV-test results registered in pre-natal cards and in hospital records. The analysis focused on coverage of HIV-testing during pregnancy and HIV prevalence rate. Logistic regression models were used to test inequalities in HIV-testing coverage during pregnancy by macro-region of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV testing; Pregnancy; Pre-natal care; Secondary data; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300002

HIV-1 drug resistance genotypic profiles in children with undetectable plasma viremia during antiretroviral therapy
Provedor de dados: 55
Autores: Angelis,Daniela Souza Araújo de; Tateno,Adriana Fumie; Diaz,Ricardo Sobhie; Succi,Regina Célia de Menezes; Pannuti,Claudio Sergio; Gouvea,Aida de Fátima Barbosa; Machado,Daisy Maria.
Treatment of HIV-1 infection with highly active antiretroviral therapy has led to sustained viral suppression in the plasma in a large number of children. However, studies have suggested that the integrated provirus in resting CD4+ T lymphocytes could be a source of reactivatable virus and maintain drug-resistant virus. We evaluated the resistance-related mutations in children receiving antiretroviral therapy with prolonged viral suppression. Thirty-two peripheral blood mononuclear cell samples from 16 children with viral loads that had been below detection limits for at least 12 months were obtained at two different time points and the DNAs sequenced. The median CD4 cell count was 1,016 cells/mm³ (347-2,588) and 938 cells/mm³ (440-3,038) at the first and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; HIV-1; Prolonged viral suppression; Antiretroviral therapy; Antiretroviral resistance.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100011

HIV-1 genotypes related to failure of nelfinavir as the first protease inhibitor treatment
Provedor de dados: 55
Autores: Tupinambás,Unaí; Aleixo,Agdemir; Greco,Dirceu.
Combined antiretroviral therapy results in sustained viral suppression and a decrease in mortality and morbidity due to HIV infection. Intrinsic strength, durability and absence of cross-resistance are key factors in the selection of antiretrovirals. Failure with nelfinavir has been associated with two protease gene mutations, D30N and L90M. The D30N mutation does not result in cross-resistance with other protease inhibitors, and it decreases viral fitness. In order to check for this mutation after failure with nelfinavir, the 246 HIV-1 genotyping test was performed on virus samples from 55 patients with failure of nelfinavir as the first protease inhibitor. Most (84%) of the viral strains were of subtype B. Nucleosides associated with mutations (NAM) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Protease inhibitors; Nelfinavir.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400009

HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil
Provedor de dados: 55
Autores: Toledo,Paula Virginia Michelon; Carvalho,Denise Siqueira de; Romagnoli,Luiza; Marcinko,Gustavo; Cunha,Clovis Arns da; Souza,Margely Nunes de; Brindeiro,Rodrigo; Queiroz-Telles,Flávio de.
Antiretroviral therapy (ART) has reduced morbidity and mortality related to human immunodeficiency virus (HIV) infection, but in spite of this advance, HIV mutations decrease antiretroviral susceptibility, thus contributing to treatment failure in patients. Genotyping HIV-1 allows the selection of new drugs after initial drug failure. This study evaluated the genotypic profile of HIV-1 isolates from treated (drug-experienced) patients in Paraná, Brazil. The prevalence of mutations in reverse transcriptase (RT) and protease (PR) genes were assessed. We analyzed 467 genotypes of patients with HIV-1 viral loads above 1,000 copies/mL. Mutations at HIV-1 RT and PR genes and previously used ART regimens were recorded. The most prevalent RT mutations were: 184V...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Genotype; Antiretrovirals; Drug-experienced patients.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400009

HIV-1 mother-to-child transmission in Brazil (1994-2016): a time series modeling
Provedor de dados: 55
Autores: Coelho,Antonio Victor Campos; Coelho,Hemílio Fernandes Campos; Arraes,Luiz Cláudio; Crovella,Sergio.
Abstract HIV-1 mother-to-child transmission (HIV-1 MTCT), is an important cause of children mortality worldwide. Brazil has been traditionally praised by its HIV/Aids program, which provides free-of-charge care for people living with HIV-1. Using public epidemiology and demographic databases, we aimed at modeling HIV-1 MTCT prevalence in Brazil through the years (1994-2016) and elaborate a statistical model for forecasting, contributing to HIV-1 epidemiologic surveillance and healthcare decision-making. We downloaded sets of live births and mothers' data alongside HIV-1 cases notification in children one year old or less. Through time series modeling, we estimated prevalence along the years in Brazil, and observed a remarkable decrease of HIV-1 MTCT...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Vertical transmission; Perinatal transmission; Biostatistics; Epidemiology; Forecasting.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400218

HIV-1 resistance testing influences treatment decision-making
Provedor de dados: 55
Autores: Diaz,Ricardo Sobhie; Sucupira,Maria Cecilia A; Vergara,Tania RC; Brites,Carlos; Bianco,Rosana Del; Bonasser Filho,Francisco; Colares,Geova Keny B; Portela,Estevão; Cherman,Lia Adler; Barcelos,Nemora Tregnago; Tupinambas,Unai; Turcato Jr,Gilberto; Allamasey,Lisa; Bacheler,Lee; Tuohy,Martin.
OBJECTIVE: To investigates how the use of HIV-1 resistance tests influences physician decision-making. METHODS: Ten experienced reference physicians from the Brazilian Network for Drug Resistance each received ten patients' case histories. The selected patients had experienced at least two virological failures. First, reference physicians were asked to empirically select a new regimen for each patient. Second, after genotype report (ViroSeq 2.6) was provided, and physicians were again asked to select a new regimen considering this additional information. Finally, they were asked to select a regimen after receiving a virtual phenotype result (vircoTYPE 3.9.00). RESULTS: In 79% of the cases, physicians changed their empirical choice of regimen after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genotype; Virtual phenotype; Antiretroviral resistance; Brazil.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500011

HIV-1 viremia during the first 28 weeks of pregnancy is not associated with mother-to-child transmission
Provedor de dados: 55
Autores: Senise,J.F.; Palacios,R.; Tanno,Z.N.; Lunardi,L.; Waghabi,G.R.; Vaz,M.J.R.; Diaz,RS.; Castelo,A.
It is currently recommended that antiretroviral prophylaxis to prevent mother-to-child transmission (MTCT) of HIV be initiated at 14 weeks of gestation. However, the relevance of early-gestation HIV viral load level for intrauterine MTCT is unknown. The objective of this study was to determine the relationship between prenatal maternal viral load and intrauterine MTCT. Records of HIV-infected pregnant women in two centers in Brazil, from 1999 to 2004 were analyzed. Three pregnancy periods were considered: earlier than 14 weeks, 14 to 27 6/7 weeks, and 28 weeks of gestation or more. Peripartum HIV exposure was also computed. Maximum viral load in each period was the measure of HIV exposure. Four hundred fifty-seven HIV-infected pregnant women were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Disease transmission; Vertical transmission; Antiretroviral therapy; Highly active; Brazil; Viral load.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400009

HIV/AIDS treatment and physicochemical quality control of medicines: evaluation of non-generic lamivudine + zidovudine tablets manufactured in Brazil
Provedor de dados: 55
Autores: Beck,Ruy Carlos Ruver; Athayde,Margareth Linde; Cardoso,Simone Gonçalves.
In this work it was evaluated the physicochemical quality of lamivudine + zidovudine tablets, whose association belongs to the list of drugs distributed by the Brazil's National Program on Sexually Transmitted Diseases and AIDS. Four non-generic products (lamivudine + zidovudine tablets) were analyzed. They were obtained from different Brazilian manufacturers, besides a reference product. The quality was evaluated by physicochemical tests described in the official codes. A validated reversed-phase high performance liquid chromatography (HPLC) method was used for the assay of the active substances. All samples were in accordance to the requisites in relation to their physicochemical characteristics. Dissolution studies showed similar drug percentual...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Quality control; Lamivudine; Public health; Tablets; Zidovudine.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600003

HIV-HCV coinfection and liver cancer
Provedor de dados: 55
Autores: Segurado,Aluisio.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500017

HIV-infected youths transitioning from pediatric to adult outpatient care in a teaching tertiary care hospital in São Paulo city, Brazil
Provedor de dados: 55
Autores: Freitas,Angela Carvalho; Avelino-Silva,Vivian Iida; Gutierrez,Eliana Battaggia; Marques,Heloisa Helena de Souza; Durigon,Giuliana Stravinskas; Segurado,Aluisio Cotrim.
ABSTRACT  Background: HIV-infected children surviving until adulthood have been transitioning to adult outpatient health care service in Brazil since the late 2000's. Deterioration of clinical condition is expected during this period, as reported among youths with non-communicable chronic diseases. Despite their young age, they are long-term hosts of the virus, have prolonged exposure to antiretroviral therapy and have suffered from the social determinants and stigma of HIV infection since early childhood.  Objectives: This study aimed to 1) describe demographic and clinical characteristics at the first appointment at adult care service following pediatric care of a cohort of Brazilian youths living with HIV since childhood; and 2) retrospectively address...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adolescent; Young adult; Pediatric HIV; Transition-to-care; Adult care.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500291

HLA profile in patients with AIDS and tuberculosis
Provedor de dados: 55
Autores: Figueiredo,José Fernando de Castro; Rodrigues,Maria de Lourdes Veronese; Deghaide,Neifi Hassam Saloum; Donadi,Eduardo Antonio.
Studies carried out in various populations have reported an association between some HLA specificities and susceptibility to tuberculosis. We investigated the class I and class II HLA profile in Brazilian patients of various ethnic backgrounds who had AIDS and tuberculosis. Twenty-two adult patients with AIDS and tuberculosis (Group I), 103 patients with AIDS without tuberculosis (Group II) and 423 healthy individuals not infected with HIV (Group III) were evaluated. Diagnosis of HIV infection was made by ELISA, confirmed by a gelatin particle agglutination test. Diagnosis of tuberculosis was made based on clinical/radiological presentation and direct bacilloscopy or clinical specimen cultures. Class I antigens were typed by microlymphotoxicity. Class II...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Tuberculosis; Host genetic factors; HLA.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400004

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
Provedor de dados: 55
Autores: Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,Carlos.
ABSTRACT  Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation.  Objective: The aim of this study was to evaluate which variants of HLA-B are associated with the risk of HIV vertical transmission in infected pregnant women and in their offspring, in a referral center in Salvador Bahia.  Methods: We performed HLA-B genotyping in 52 HIV-infected mothers and their children exposed to HIV-1 during pregnancy (N = 65) in Salvador, Brazil. We compared the HLA-B alleles frequency in mothers,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mother to child transmission; HIV; HLA-B.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200071

HLA-B*5701 frequency in Chilean HIV-infected patients and in general population
Provedor de dados: 55
Autores: Poggi,Helena; Vera,Alejandra; Lagos,Marcela; Solari,Sandra; Rodríguez P,Luis; Pérez,Carlos M.
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to abacavir in HIV-infected patients. Since B*5701 prevalence varies among different populations, it is important to determine the carrier frequency prior to its use for the screening of HIV-infected patients.The aim of this study was to determine HLA-B*5701 carrier frequency in Chilean general population and HIV-infected patients referred for B*5701 typing. For that purpose 300 blood bank donors and 492 abacavir-naïve HIV-infected patients from Chile were screened for B*5701 by a sequence specific primer PCR.We detected 14/300 (4.7%) B*57-positive individuals in the Chilean general population, 11 (3.7%) were B*5701 positive, and 3 (1%) had another subtype.All...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HLA-B*5701; HIV; Abacavir; Chile; Pharmacogenetics.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500015

HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Provedor de dados: 55
Autores: Silva,Edinete Melo da; Acosta,Angelina Xavier; Santos,Eduardo José Melo; Netto,Eduardo Martins; Lemaire,Denise Carneiro; Oliveira,Adriano Silva; Barbosa,Carolina Matos; Bendicho,Maria Teresita; Galvão-Castro,Bernardo; Brites,Carlos.
Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher's exact and ANOVA tests for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; MHC; HLA; Polymorphism.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500008

Hospital gowns as a vehicle for bacterial dissemination in an intensive care unit
Provedor de dados: 55
Autores: Pilonetto,Marcelo; Rosa,Edvaldo Antonio Ribeiro; Brofman,Paulo Roberto Slud; Baggio,Daniela; Calvário,Francine; Schelp,Cristiane; Nascimento,Aguinaldo; Messias-Reason,Iara.
The microbiota from the uniforms of 31 professionals from the general intensive care unit was analyzed. The samples were collected in duplicate at the beginning and at the end of the work period. Total viable counts of microorganisms were determined; there was a significant increase in the counts at the end of the period, when compared with those obtained at the beginning. No significant difference was observed between the first and second counts obtained from the cuffs. However, differences were observed for the samples from the abdominal region. Among the isolated pathogens 11/18 were Staphylococcus aureus, 2/18 were Acinetobacter baumannii, 2/18 were Klebsiela pneumoniae and 1/18 were Serratia rubidae. Some of these isolates were multi-resistant to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gown; Bacteria; Hospital infection; Cross contamination.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300003

Hospital-associated funguria: analysis of risk factors, clinical presentation and outcome
Provedor de dados: 55
Autores: Carvalho,Mauricio; Guimarães,César Maistro; Mayer Júnior,José Ronaldo; Bordignon,Gisele P. Fernandes; Queiroz-Telles,Flávio.
Fungal urinary tract infections are an increasing problem in hospitalized patients. Funguria may be a result of contamination of the urine specimen, colonization of the urinary tract, or may be indicative of true invasive infection. In this study, we report the risk factors, clinical features, treatments and outcome in a group of 68 hospitalized patients (adults and children) with fungal isolates recovered from 103 urinary samples. Underlying medical conditions were present in most patients. In the pediatric group, urinary tract abnormalities (86%) and prematurity (19%) accounted for the majority of the cases. Diabetes mellitus (28%), nephrolithiasis, and benign prostatic hyperplasia were the most common diseases in adults. Indwelling urethral catheters...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Funguria; Candiduria; Fungal infections.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600004

Hospitalization rates, length of stay and in-hospital mortality in a cohort of HIV infected patients from Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Coelho,Lara E.; Ribeiro,Sayonara R.; Veloso,Valdilea G.; Grinsztejn,Beatriz; Luz,Paula M.
Abstract In this study, we evaluated trends in hospitalization rates, length of stay and in-hospital mortality in a cohort of HIV-infected patients in Rio de Janeiro, Brazil, from 2007 through 2013. Among the 3991 included patients, 1861 hospitalizations occurred (hospitalization rate of 10.44/100 person-years, 95% confidence interval 9.98–10.93/100 person-years). Hospitalization rates decreased annually (per year incidence rate ratio 0.92, 95% confidence interval 0.89–0.95) as well as length of stay (median of 15 days in 2007 vs. 11 days in 2013, p-value for trend &lt; 0.001), and in-hospital mortality (13.4% in 2007 to 8.1% in 2013, p-value for trend = 0.053). Our results show that, in a middle-income setting, hospitalization rates are decreasing over...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Hospitalization; Length of stay; In-hospital mortality.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200190

How are HCV-infected patients being identified in Brazil: a multicenter study
Provedor de dados: 55
Autores: Portari-Filho,Luiz H.; Álvares-da-Silva,Mario R.; Gonzalez,Aline; Ferreira,Adalgisa P.; Nogueira,Cristiane V.; Mendes-Correa,Maria C.; Lima,José M.; Lopes,Edmundo P.; Brandão,Carlos E.; Ivantes,Cláudia; Lyra,André; Lindenberg,Andreia; Ferraz,Maria L.
ABSTRACT  Background: Hepatitis C is an important health problem. In Brazil, 1-2 million people are infected. Despite this expressive number, and the availability of very successful treatment, many patients remained undiagnosed mainly because of the asymptomatic nature of the infection.  Objectives: To describe epidemiological characteristics of HCV-infected patients seen at referral centers in Brazil, the source of referral, and the time spanned to reach a reference center, in order to improve the identification of undiagnosed patients.  Methods: Multicenter observational, cross-sectional study carried out in 15 centers of Brazil, between January/2016 and June/2017. Data of patients with a confirmed diagnosis (anti-HCV and HCV-RNA) were collected by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Hepatitis C; HCV; Brazil.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100034

How to detect new viral outbreaks or epidemics? We need to survey the circulation of viruses in humans and other animals using fast, sensible, cheap, and broad-spectrum methodologies
Provedor de dados: 55
Autores: Ellwanger,Joel Henrique; Kaminski,Valéria de Lima; Chies,José Artur Bogo.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200211

How we can utilize the Xpert MTB/RIF assay to decide on airborne infection isolation of inpatients with tuberculosis suspicion in Brazil: a brief review of the current data
Provedor de dados: 55
Autores: Resende,Mariângela Ribeiro.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100105

HPV infection and intraepithelial lesions from the anal region: how to diagnose?
Provedor de dados: 55
Autores: Carvalho,Newton Sérgio de; Ferreira,Aliana Meneses; Bueno,Camila Caroline Tremel.
In the last years, the prevalence of HPV infection in the anal region has increased, especially in some groups like homosexual and HIV-positive people. Since this infection can be associated with the development of squamous anal cancer due to its progression from HPV infection to anal intraepithelial neoplasia (AIN) and finally to cancer, the screening and evaluation of these conditions are important. Anal cytology and high resolution anoscopy are good methods that are available and can be used. Although useful, these methods should be performed correctly and not indiscriminately in all patients. Patients for whom anal cytology screening is recommended are: HIV-infected patients, homosexuals, women who present with high-grade vulvar squamous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anal canal; Papillomavirus infections; Cell biology; Carcinoma in situ.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500010

HPV infection, risk factors and viral load among Mexican male college students
Provedor de dados: 55
Autores: Vera-Uehara,Carmina; Sánchez-Alemán,Miguel Angel; Uribe-Salas,Felipe Javier; Ramos-Castañeda,José; Olamendi-Portugal,Ma. Leónidez; Conde-Glez,Carlos Jesús.
Objectives:To determine the prevalence of HPV and the risky sexual behaviors associated to it in a sample of male college students, taking into account genotype and viral load.Methods:From 2002 to 2003, male students from the Autonomous University of Morelos State completed a questionnaire and provided self-collected genital samples to detect and quantify HPV. We performed a bivariate and a multivariate logistic regression analysis to identify correlates associated with the infection and to assess the viral load as a function of the viral infecting type. The fragments of β-globin gene and L1 of HPV, were amplified, purified and cloned, to evaluate viral load.Results:Among 253 subjects, HPV prevalence was 19.4%, and HPV16 was the most common subtype....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Viral load; Contraceptive pills; Risky sexual behaviors; Male; Students.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100071

HPV-related external genital lesions among men residing in Brazil
Provedor de dados: 55
Autores: Silva,Roberto Jose Carvalho da; Sudenga,Staci Lynn; Sichero,Laura; Baggio,Maria Luiza; Galan,Lenice; Cintra,Ricardo; Torres,Benji Nelson; Stoler,Mark; Giuliano,Anna Regina; Villa,Luisa Lina.
Abstract The aims of this study were to determine the incidence of external genital lesions (EGLs), specifically histologically confirmed condyloma (genital warts) and Penile Intraepithelial Neoplasia (PeIN), and genital HPV infection progression to EGLs among healthy men aged 18-73 residing in Brazil. Subjects included 1118 men enrolled in the HPV Infection in Men (HIM) study between July 2005 and June 2009. At each visit, EGLs were biopsied and subjected to pathological evaluation. HPV status in genital swabs and biopsies was determined by Linear Array and INNO-LiPA, respectively. Age-specific EGLs incidence and the proportion and median time to EGL development were estimated. Kaplan-Meier cumulative incidence rates at 6, 12, and 24 months were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Men; Genital lesions; PeIN; Condyloma; HPV.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400376

HTLV-1 p12I and p30II proteins in viral persistence and pathogenesis
Provedor de dados: 55
Autores: Franchini,Genoveffa; Fukumoto,Risaku; Dundr,Mirek; Valeri,Valerio William.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500031

Human ehrlichioses in Brazil: first suspect cases
Provedor de dados: 55
Autores: Calic,Simone B.; Galvão,Márcio A.M.; Bacellar,Fátima; Rocha,Christiane M. B. M.; Mafra,Cláudio L.; Leite,Romário C.; Walker,David H.
Brazilian spotted fever (BSF) rickettsiosis is the most common and recognized of the human rickettsioses in Brazil. It is difficult to establish the diagnosis of human rickettsiosis infection by routine microbiologic methods, creating a false idea that Rickettsia and Ehrlichia infections are rare and without importance. New tick-borne diseases, like Human Granulocytic Anaplasmosis (HGA) and Human Monocytic Ehrlichiosis (HME), have been described in many countries. These diseases can present symptoms similar to rickettsioses of the spotted fever group, and they are transmitted by ixodid ticks. The first two suspected cases of human ehrlichiosis in Brazil were first considered to be cases of BSF. The differential diagnosis was made at the Minas Gerais...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rickettsioses; Human ehrlichioses; Brazilian spotted fever; Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300011

Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis
Provedor de dados: 55
Autores: Seyyedi,Noorossadat; Dehbidi,Gholamreza Rafiei; Karimi,Mozhgan; Asgari,Amir; Esmaeili,Babak; Zare,Farahnaz; Farhadi,Ali; Dabbaghmanesh,Mohammad Hossein; Saki,Forough; Behzad-Behbahani,Abbas.
ABSTRACT  Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Human herpesvirus-6 (HHV-6) is recognized for its contribution to some autoimmune diseases.  Objective: In the current study, the prevalence of HHV-6 active infection in patients with HT and with non-autoimmune thyroid disorders were compared with patients with euthyroidism. In addition, a correlation between presence of HHV-6 infections and HT was investigated.  Methods:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human herpesvirus 6; Prevalence; Hashimoto disease; Autoimmune diseases.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600435

Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection
Provedor de dados: 55
Autores: Guardia,Ana Carolina; Stucchi,Raquel Silveira Bello; Milan,Arlete; Costa,Sandra Cecília Botelho; Boin,Ilka de Fátima Santana Ferreira.
Herpesvirus reactivation is common after liver transplantation.OBJECTIVE:Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection.METHODS:Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied.RESULTS:Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Liver transplantation; Human herpesvirus 6; Cytomegalovirus; Liver donor biopsies.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200220

Human herpesvirus-8 (HHV-8) antibodies in women from São Paulo, Brazil: association with behavioral factors and Kaposi's sarcoma
Provedor de dados: 55
Autores: Caterino-de-Araujo,Adele; Santos-Fortuna,Elizabeth de los; Carbone,Paulo Henrique Lage; Cibella,Sandra Elisa Lopes; Moreira,Abdiel Aparecido.
BACKGROUND: With the spread of AIDS, many HIV-infected women have been diagnosed with Kaposi's sarcoma (KS), especially in Africa. Since the discovery of a novel herpesvirus as the causative agent of KS (human herpesvirus 8 - HHV-8) several seroepidemiological studies have been conducted to identify groups at risk for KS. The risk for women in Brazil has not been studied. MATERIALS AND METHODS: We searched for HHV-8 antibodies in sera obtained from a bank made up of samples from 3 groups of individuals: Group I: 163 HIV-1-infected women attended at an ambulatory clinic in 1994; Group II: 108 children born to HIV-1-infected mothers from 1990 to 1992, their antibodies reflected maternal infection, and Group III: 630 HIV-1-seronegative, healthy women....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human herpesvirus - 8 (HHV-8) anti-lytic and anti-latent antibodies; HHV-8 infection in women; HHV-8 in HIV-1 infected women; HHV-8 seroprevalence; HHV-8 infection; Kaposi's sarcoma (KS).
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600007

Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation
Provedor de dados: 55
Autores: Raboni,Sonia Mara; Tuon,Felipe Francisco; Beloto,Nayara Carvalho Polido; Demeneck,Henrique; Oliveira,Andre; Largura,Denis; Sagrado,Andressa Gervasoni; Lima,Bárbara Perdonsini; Franzoni,João Paulo; Pedroso,Maria Lucia.
Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Parana, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Human immunodeficiency virus; Hepatitis B; Hepatitis C; Co-infection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600664

Human immunodeficiency virus and the central nervous system
Provedor de dados: 55
Autores: Almeida,Sergio Monteiro de; Letendre,Scott; Ellis,Ron.
The pandemic of HIV/AIDS continues to grow daily. Incident cases among women, intravenous drug users and ethnic minorities comprise the fastest growing segment of the HIV-infected population, and the number of HIV-infected individuals over the age of 50 is growing rapidly. Today, the central nervous system and the immune system are seen as main targets of HIV infection. Significant progress in the knowledge and treatment of AIDS has been obtained in recent years. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; HIV dementia; Central nervous system; Cerebrospinal fluid; Viral load; Chemokines.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100009

Human immunodeficiency virus infection and its association with sarcopenia
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Sales,Marina Cerqueira; Scaramussa,Eduarda Sobral; da Paz,Clara Junia Calazans; Morelato,Renato Lirio.
Abstract Presarcopenia and sarcopenia were evaluated in HIV-infected individuals and in healthy elderly controls according to the consensus definitions of the European Working Group on Sarcopenia in Older People. Bioelectrical impedance, a hydraulic hand dynamometer, and gait speed were used to evaluate muscle mass, muscle strength, and physical performance, respectively. Adjusted and unadjusted binary logistic regression predicted the risk of sarcopenia. Predictor contribution was assessed by the Wald test. Significance was established at p ≤ 0.05. The HIV-infected group consisted of 33 patients on treatment (42.4% women; mean age 59 ± 7 years; mean BMI 25 ± 6 kg/m2; viral load undetectable in 30 cases). The HIV-uninfected group consisted of 60...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sarcopenia; HIV; Frailty.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100099

Human papillomavirus detection and typing using a nested-PCR-RFLP assay
Provedor de dados: 55
Autores: Coser,Janaina; Boeira,Thaís da Rocha; Fonseca,André Salvador Kazantzi; Ikuta,Nilo; Lunge,Vagner Ricardo.
BACKGROUND: It is clinically important to detect and type human papillomavirus (HPV) in a sensitive and specific manner. OBJECTIVES: Development of a nested-polymerase chain reaction-restriction fragment length polymorphism (nested-PCR-RFLP) assay to detect and type HPV based on the analysis of L1 gene. METHODS: Analysis of published DNA sequence of mucosal HPV types to select sequences of new primers. Design of an original nested-PCR assay using the new primers pair selected and classical MY09/11 primers. HPV detection and typing in cervical samples using the nested-PCR-RFLP assay. RESULTS: The nested-PCR-RFLP assay detected and typed HPV in cervical samples. Of the total of 128 clinical samples submitted to simple PCR and nested-PCR for detection of HPV,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DNA probes; HPV polymerase chain reaction polymorphism; Restriction fragment length.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500009

Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study
Provedor de dados: 55
Autores: Carvalho,M.O.O; Carestiato,F.N; Perdigão,P.H; Xavier,M.P.P.T; Silva,KC; Botelho,M.O; Oliveira,L.H.S.; Cavalcanti,S.M.B.
There is considerable data to support a central role for human papillomavirus (HPV) in the etiology of cervical cancer. More than a 100 HPV types have been described, and 40 have been isolated from benign and malignant genital lesions. Consequently, there is strong motivation to evaluate HPV testing for cervical cancer screening. Few studies concerning the natural history of HPV infection have been conducted in the state of Rio de Janeiro. We determined the prevalence of HPV types in female genital lesions by using Hybrid Capture Assay (HCA) and we retrospectively analyzed the course of HPV infection. Our sample included 788 women attended at Laboratórios Sérgio Franco. The average age of the participants was 29.6 years. HPV prevalence and cytological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Cervical cancer; Rio de Janeiro; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500007

Human Papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women
Provedor de dados: 55
Autores: Levi,José E.; Fink,Maria C.S.; Canto,Cynthia L.M.; Carretiero,Nadily; Matsubara,Regina; Linhares,Iara; Dores,Gérson B. das; Castelo,Adauto; Segurado,Aluísio; Uip,David E.; Eluf Neto,José.
HIV-infected women from São Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD4+ cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD4/µL &lt;100) were at the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human Papillomavirus; Cervical intraepithelial neoplasia; HIV-infected women; Viral load; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300005

Human parechovirus: sepsis-like illness with pulmonary infection
Provedor de dados: 55
Autores: Vidal,Luíne Rosele Renaud; Cavalli,Bárbara; Almeida,Sérgio Monteiro de; Raboni,Sônia Mara; Nogueira,Meri Bordignon.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600675

Human T cell lymphotropic virus type 1 infection among men who have sex with men in Central Brazil
Provedor de dados: 55
Autores: Castro,Lisie Souza; Rezende,Grazielli Rocha de; Fernandes,Fernanda Rodas Pires; Bandeira,Larissa Melo; Puga,Marco Antonio Moreira; Tanaka,Tayana Serpa Ortiz; Weis-Torres,Sabrina Moreira dos Santos; Vicente,Ana Carolina Paulo; Otsuki,Koko; Motta-Castro,Ana Rita Coimbra.
ABSTRACT Human T cell lymphotropic virus type 1 (HTLV-1) was the first retrovirus discovered in humans and is endemic in several parts of the world. Because of risk behaviors, mainly sexual, men who have sex with men (MSM) are at high risk of acquiring HTLV-1 infection. A cross-sectional study was performed to estimate the prevalence of HTLV-1 infection, to characterize genetically HTLV-1 sequences and to identify risk behaviors associated with this infection among MSM in Central Brazil. A total of 430 MSM were enrolled in this study and three were shown to be HTLV-1 infected, prevalence of 0.7% (95% confidence interval: 0.4-0.9). Phylogenetic analysis showed that all HTLV-1 positive samples belonged to Cosmopolitan subtype Transcontinental subgroup A....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; Men who have sex with men; Sexual risk behavior; Molecular epidemiology; Brazil.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600472

Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations
Provedor de dados: 55
Autores: Leal,Elida A.; Moreira,Josimar D.; Nunes,Fernanda F.; Souza,Larissa R.; Martins,Janaina M.; Toledo,Vicente P.C.; Almeida,Alzira M.P.; Guimarães,Tania M.P.
ABSTRACT  Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response.  Methods: The immunogenicity of antigenic preparations based on the Y. pestis (YP) total extract and the Y. pestis fraction 1 capsular antigen protein (F1) was determined in Swiss-Webster mice immunized with 40 µg or 20 µg for each...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Yersinia pestis; Antigens; Mice; Immune response; Vaccines.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600620

Humoral immune response to measles and varicella vaccination in former very low birth weight preterm infants
Provedor de dados: 55
Autores: Ferreira,Carolina Schlindwein Mariano; Perin,Maria Cristina Abrão Aued; Moraes-Pinto,Maria Isabel de; Simão-Gurge,Raquel Maria; Goulart,Ana Lucia; Weckx,Lily Yin; dos Santos,Amélia Miyashiro Nunes.
ABSTRACT  Introduction: Immune response to vaccination in infants born prematurely may be lower than in infants born at full-term. Some clinical factors might be associated with humoral immune response.  Objectives: The objectives of this study were to compare the immune response to measles and varicella vaccination in infants born prematurely with those born at full-term and to analyze factors associated with measles and varicella antibody levels.  Methods: Prospective study including two groups of infants aged 12 months. One group of infants born prematurely with birth-weight &lt;1500 g and who were in follow-up at the outpatient clinic for preterm infants at the institution and other group of infants born at full-term. Infants with malformations,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Premature; Vaccination; Humoral immunity; Measles; Varicella.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100041

Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis
Provedor de dados: 55
Autores: Ávila,Renata Eliane de; Carmo,Ricardo Andrade; Farah,Kátia de Paula; Teixeira,Antônio Lúcio; Coimbra,Lucas Viana; Antunes,Carlos MaurÃ­cio de Figueiredo; Lambertucci,José Roberto.
BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR &gt; F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver fibrosis; Hyaluronic acid; End-stage renal disease; Haemodialysis; Hepatitis C.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004

Hybrid capture as a tool for cervical lesions screening in HIV-infected women: insights from a Brazilian cohort
Provedor de dados: 55
Autores: Jalil,Emilia Moreira; Luz,Paula M.; Quintana,Marcel; Friedman,Ruth Khalili; Madeira,Rosa M. Domingues S.; Andrade,Angela Cristina; Chicarino,Janice; Moreira,Ronaldo Ismerio; Derrico,Monica; Levi,José Eduardo; Russomano,Fabio; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.
ABSTRACT  Introduction: Cervical cancer remains an important burden for HIV-infected women in the era of combination antiretroviral therapy. Recommendations for cervical screening in these women diverge and may include high-risk HPV (HRHPV) testing. We aimed to evaluate the clinical usefulness of a single HRHPV testing for cervical screening of HIV-infected women.  Methods: 723 HIV-infected women from a Brazilian prospective cohort were included between 1996 and 2012. Inclusion criteria were: normal cervical cytology at baseline and having a HRHPV-test at baseline. We calculated incidence rates of any squamous intraepithelial lesion (SIL) and high grade SIL+ (HSIL+) and negative predictive values (NPV) within 12 and 36 months. Hazard Ratios were obtained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; HIV; Women; Cohort; Incidence.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100016

Hyperlipidaemia - a risk factor for femoral head osteonecrosis (Legg-Calvè-Perthes-Like disease) in children with AIDS: case report
Provedor de dados: 55
Autores: Aragão,Paula Aguiar de; Lemos,Renata B. P.; Aquino,Maria Zilda; Marques,Heloísa Helena Souza.
Although treatment of children infected with HIV with protease inhibitors has improved the survival of these patients, various adverse side effects have been reported, including metabolic abnormalities, such as hyperlipidaemia. We describe a case of hip osteonecrosis in an adolescent with AIDS who was being treated with protease inhibitors. There is a possible relation with hyperlipidemia. F.M.G., white, 11 years old, AIDS A2, started to receive AZT and DDI when he was 7 years old. In April 1999, the patient had a significant increase in viral load and so the antiretroviral therapy was switched to d4T, 3TC and Ritonavir. Triglyceride plasma levels reached 460mg/dl after this switch and were always above the reference value. In December 1999, the patient...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyperlipidaemia; Femoral head osteonecrosis; Children; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300008

Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate
Provedor de dados: 55
Autores: Caramelli,Bruno; Bernoche,Claudia Y.S.M. de; Sartori,Ana M. C.; Sposito,Andrei C.; Santos,Raul D.; Monachini,Maristela C.; Strabelli,Tania; Uip,Davi.
Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p&lt;0.0006 and p&lt;0.0001) were observed....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cholesterol; Lipids; HIV infection; Triglycerides.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007

Hyperreactive malarious splenomegaly and aids: a case report
Provedor de dados: 55
Autores: Tano,Zuleica Naomi; Filho,Chafic Esper Kallas; Breganó,Regina Mitsuka; Pavanelli,Wander Rogério; Ruzon,Uheyna Gancedo.
Malaria is endemic in the North of Brazil. However, Hyperreactive Malarious Splenomegaly (HMS) has been rarely described. Splenomegaly in HIV/Aids infection has a large differential diagnosis, but malaria is a cause of gross splenomegaly, regardless of the HIV status. In this paper, we report the case of a 50-year-old man, HIV positive, with massive splenomegaly and multiple malaria infections in the past. He fulfilled the criteria for HMS, received a short course of anti-malarial treatment and weekly quimioprofilatic Chloroquine. In 9 months, he had great clinical and laboratorial improvement confirming the HMS, a rare diagnosis in Brazil.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hyperreactivemalarious; Splenomegaly; Aids.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500565

Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis
Provedor de dados: 55
Autores: Libório,Alexandre B.; Silva Jr,Geraldo B.; Silva,Carolina G.C.H.; Lima Filho,Francisco J.C.; Studart Neto,Adalberto; Okoba,Willy; Bruin,Veralice M.S. de; Araújo,Sônia M.H.A.; Daher,Elizabeth F.
BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE). METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted. RESULTS: A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Encephalitis; Hyponatremia; Acute kidney injury; HIV; Mortality.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600010

I Consensus for the Management and Treatment of Hepatitis B Carried Out by the Brazilian Society of Infectious Diseases
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100002

Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil
Provedor de dados: 55
Autores: Queiroz,Artur Trancoso Lopo de; Santos,Luciane Amorim; Moreau,Domingos Ramon; Oliveira,Tulio de; Watkins,David I.; Galvão-Castro,Bernardo; Alcantara,Luiz Carlos Junior.
Genetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Env; Vaccine; Epitope.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100008

Identification and detection of methicillin resistance in Non-Epidermidis coagulase-negative staphylococci
Provedor de dados: 55
Autores: Secchi,Carina; Antunes,Ana Lúcia Souza; Perez,Leandro Reus Rodrigues; Cantarelli,Vlademir Vicente; d'Azevedo,Pedro Alves.
The NCCLS (2004) presented a new methodology to detect, by disk-diffusion agar, oxacillin-resistance using a cefoxitin disk. We identified coagulase-negative staphylococci (SCoN) to the species level and compared the use of cefoxitin disks (30 µg) with oxacillin disks (1 µg), agar dilution (minimum inhibitory concentration of oxacillin) and mecA gene detection in isolates of coagulase-negative bacteria other than Staphylococcus epidermidis (SCoNne). A total of 238 SCoNne was evaluated; oxacillin-resistance (the mecA gene) was detected in 71% of the isolates. All methods gave 100% sensitivity, based on presence of the mecA gene. The specificity of the cefoxitin disk was 100%, while the oxacillin disk gave a specificity of 91% and agar dilution oxacillin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coagulase-negative Staphylococcus; Cefoxitin; Oxacillin; MecA gene; Susceptibility diagnostic.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400012

Identification of hepatitis B virus A1762T/G1764A double mutant strain in patients in Southern Brazil
Provedor de dados: 55
Autores: Silva Souza,Adaliany Cecília da; Souza Marasca,Giórgia de; Kretzmann-Filho,Nélson Alexandre; Dall-Bello,Aline; Kliemann,Dimas Alexandre; Tovo,Cristiane Valle; Veiga,Ana Beatriz Gorini da.
Abstract Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing cirrhosis and/or hepatocellular carcinoma. This study analyzed the presence of the HBV A1762T/G1764A double mutant in patients with chronic HBV and its association with clinical parameters such as viral load, aminotransferases, and HBV antigens. A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; HBV; A1762T/G1764A mutation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500525

Identification of Human Bocavirus type 4 in a child asymptomatic for respiratory tract infection and acute gastroenteritis - Goiânia, Goiás, Brazil
Provedor de dados: 55
Autores: Sousa,Teresinha Teixeira de; Almeida,Tâmera Nunes Vieira; Fiaccadori,Fabíola Souza; Souza,Menira; Badr,Kareem Rady; Cardoso,Divina das Dôres de Paula.
Abstract Human Bocavirus (HBoV) has been identified from feces and respiratory samples from cases of both acute gastroenteritis and respiratory illness as well as in asymptomatic individuals. The aim of this study was to detect and characterize HBoV from fecal samples collected from hospitalized children aged less than five years old with no symptoms of respiratory tract infection (RTI) or acute gastroenteritis (AGE). The study involved 119 children and one fecal sample was collected from each participant between 2014 and 2015. HBoV was detected using Nested-PCR, and the viral type identified by genomic sequencing. HBoV-4 was identified from one sample obtained from a hospitalized child with soft tissue tumor of the submandibular region. This is the first...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HBoV-4; Asymptomatic children; Tumor of the submandibular region.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400472

Identification of Leishmania (Leishmania) chagasi isolated from healthy skin of symptomatic and asymptomatic dogs seropositive for leishmaniasis in the Municipality of Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Madeira,Maria de Fátima; Schubach,Armando de Oliveira; Schubach,Tânia Maria Pacheco; Leal,Cristianni Antunes; Marzochi,Mauro Célio de Almeida.
Euthanasia of seropositive dogs has been one of the principal measures adopted by the Program for the Control of Leishmaniasis in Brazil for many years. However, its efficacy is currently being questioned. We obtained intact skin samples from 20 Leishmania-reactive dogs from the municipality of Rio de Janeiro that had been referred for euthanasia. The promastigote forms of Leishmania were isolated in culture from 18 of these animals. Fourteen of these isolates were identified as Leishmania (Leishmania) chagasi by isoenzyme electrophoresis; seven of these were from asymptomatic dogs and seven were from symptomatic animals with visceral leishmaniasis. In conclusion, cutaneous parasitism is found in the intact skin of dogs naturally infected with L. (L.)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania (Leishmania) chagasi; Isoenzymes; Dog; Intact skin; Clinical signs.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600008

Identification of putative new Escherichia coli flagellar antigens from human origin using serology, PCR-RFlP and DNA sequencing methods
Provedor de dados: 55
Autores: Tiba,Monique Ribeiro; Moura,Claúdia de; Carazzolle,Marcelo Falsarella; Leite,Domingos da Silva.
Escherichia coli has been isolated frequently, showing flagellar antigens that are not recognized by any of the 53 antisera, provided by the most important reference center of E. coli, The International Escherichia and Klebsiella Center (WHO) of the Statens Serum Institute, Copenhagen, Denmark. The objective of this study was to characterize flagellar antigens of E. coli that express non-typeable H antigens. The methods used were serology, PCR-RFLP and DNA sequencing. This characterization was performed by gene amplification of the fliC (flagellin protein) by polymerase chain reaction in all 53 standards E.coli strains for the H antigens and 20 E. coli strains for which the H antigen was untypeable. The amplicons were digested by restriction enzymes, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Escherichia coli; Antigens; Bacterial; Polymerase chain reaction; Polymorphism; Restriction fragment length.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200009

Identifying and controlling a multiresistant pseudomonas aeruginosa outbreak in a latin-american cancer centre and its associated risk factors
Provedor de dados: 55
Autores: Cortes,Jorge Alberto; Cuervo,Sonia Isabel; Urdaneta,Ana María; Potdevin,Guillermo; Arroyo,Patricia; Bermúdez,Diana; Correa,Adriana; Villegas,María Virginia.
Pseudomonas aeruginosa is an important and frightening microorganism for patients suffering from cancer. Multiresistant P. aeruginosa (MRPA) may appear as a consequence of exposure to multiple antibiotics or from a breakdown in infection control practices. This article reports an MRPA outbreak in a cancer treatment centre and the consequent case control study. Mechanical ventilation was identified as being the main risk factor for developing MRPA colonisation or infection; molecular analysis confirmed the outbreak. A multifaceted strategy was adopted, involving reinforcing hand-washing practices, contact isolation, antibiotic restriction and suction devices for mechanically-ventilated patients. MRPA was controlled and the outbreak ended. Such strategy may...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Epidemiology; Multiple drug resistance; Bacteria; Risk factor.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200005

Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy
Provedor de dados: 55
Autores: He,Bo; Zheng,Yuhuang; Liu,Meng; Zhou,Guoqiang; Chen,Xia; Mamadou,Diallo; He,Yan; Zhou,Huaying; Chen,Zi.
Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients. In this study, we monitored immune reconstitution inflammation syndrome occurrence in 238 AIDS patients treated with highly active anti-retroviral therapy. Among them, immune reconstitution inflammation syndrome occurred in 47 cases (19.7%). Immune reconstitution inflammation syndrome patients had significantly higher rate of opportunistic infection (p &lt; 0.001) and persistently lower CD4+ cell count (p &lt; 0.001) compared to the non-immune reconstitution inflammation syndrome patients. In contrast, no significant differences in HIV RNA loads were observed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: IRIS; AIDS; HIV; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200009

IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage
Provedor de dados: 55
Autores: Jee,Babban; Sharma,Pawan; Katoch,Kiran; Joshi,Beenu; Awasthi,Sudhir Kumar.
Abstract Mycobacterium tuberculosis (MTB) adopts a special survival strategy to overcome the killing mechanism(s) of host immune system. Amongst the many known factors, small heat shock protein 16.3 (sHSP16.3) of MTB encoded by gene hspX has been reported to be critical for the survival of MTB. In the present study, the effect of recombinant murine interferon-gamma (rmIFN-γ) and recombinant murine interleukin-10 (rmIL-10) on the expression of gene hspX of MTB in murine macrophage RAW264.7 has been investigated. By real-time RT-PCR, it was observed that three increasing concentrations (5, 25 and 50 ng/ml) of rmIFN-γ significantly up-regulated the expression of hspX whereas similar concentrations of rmIL-10 (5, 25 and 50 ng/ml) significantly down-regulated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; HspX; RmIFN-γ; RmIL-10; Murine macrophage.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400386

IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis
Provedor de dados: 55
Autores: Pinto Junior,Vitor Laerte Laerte; Rebelo,Maria Cristina; Gomes,Rachel Novaes; Assis,Edson Fernandes de; Castro-Faria-Neto,Hugo C; Bóia,Marcio Neves.
Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p &lt; 0.05). CSF IL-8 levels were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CSF; Inflammation meningitis; Aseptic meningitis; Bacteria; IL-6; IL-8.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200011

Imbalance of Th17 and Treg in peripheral blood mononuclear cells of active tuberculosis patients
Provedor de dados: 55
Autores: Luo,Jie; Zhang,Mingxu; Yan,Baosong; Zhang,Kejun; Chen,Ming; Deng,Shaoli.
Abstract  Objective: Maintaining a right balance between Th17 and Treg might be critical to the immunopathogenesis of active tuberculosis (TB). This study aimed to assess whether the Th17/Treg balance is altered in active TB patients.  Methods: 250 study subjects (90 active TB patients, 80 latent TB subjects, and 80 healthy controls) were recruited for the study. The expression of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) in the 250 subjects was investigated by flow cytometry. Plasma levels of cytokines IL-17 and IL-10, which are related to Th17 and Treg, respectively, were determined by ELISA.  Results: The percentages of Th17 and Treg in PBMCs from active TB patients were significantly higher than those from latent TB or control groups...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Active tuberculosis; Th17; Treg; IL-17; IL-10.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200155

Immediate start of antiretroviral, why not?
Provedor de dados: 55
Autores: Matsuda,Elaine Monteiro; Coelho,Luana Portes Ozório; Ahagon,Cintia Mayumi; Campos,Ivana Barros; Brígido,Luís Fernando de Macedo.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300250

Immune cellular response to HPV: current concepts
Provedor de dados: 55
Autores: Gonçalves,Maria Alice Guimarães; Donadi,Eduardo Antonio.
Although cellular immunity is essential for the elimination of human papillomavirus (HPV), the mechanisms involved are still poorly understood. We summarize the main mechanisms involved in cellular immune response to infections caused by HPV. Immunotherapies for HPV-related cancers require the disruption of T-cell response control mechanisms, associated with the stimulation of the Th1 cytokine response.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human papillomavirus (HPV); Cervical intraepithelial neoplasia (CIN); Uterine cervical cancer; Cellular immune response; Cytokines.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100001

Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection
Provedor de dados: 55
Autores: Nahrevanian,Hossein.
Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting reports concerning the clinical significance of NO in malaria. Some researchers have proposed that NO contributes to the development of severe and complicated malaria, while others have argued that NO has a protective role. Infection with parasites resistant to the microbicidal action of NO may result in high levels of NO being generated, which could then damage the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: INOS; Malaria; Nitric oxide; NO; RNI.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400014

Immune reconstitution inflammatory syndrome associated with pulmonary sarcoidosis in an HIV-infected patient: an immunohistochemical study
Provedor de dados: 55
Autores: Miranda,Érique José Peixoto de; Leite,Olavo Henrique Munhoz; Duarte,Maria Irma Seixas.
Sarcoidosis has been rarely described in literature as a cause of interstitial pulmonary disease associated with AIDS. This study reports a case of immune reconstitution inflammatory syndrome associated with pulmonary sarcoidosis in a patient with a history of previous pulmonary tuberculosis concomitant with HIV infection. Results of the immunohistochemical study of samples from the resected right lower lobe are described. Pathological findings suggest a role of Th1, Th2 and Th17 response in IRIS associated sarcoidosis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Acquired immunodeficiency syndrome sarcoidosis; Pulmonary immune reconstitution inflammatory syndrome immunohistochemistry.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600018

Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro
Provedor de dados: 55
Autores: Serra,Fabiana C.; Hadad,David; Orofino,Renata L.; Marinho,Flavia; Lourenço,Cristina; Morgado,Mariza; Rolla,Valeria.
We made a retrospective longitudinal study from January 2000 to January 2003 to examine cases of immune reconstitution syndrome (IRS) and its incidence rate in tuberculosis (TB)-human immunodeficiency virus (HIV) co-infected patients. The incidence rate (IR) was calculated using a Poisson regression. The confidence interval (CI) that was stipulated was 95%. IRS occurred in 10/84 HIV and TB-positive patients; nine of them were on highly active anti-retroviral therapy (HAART) during a mean of 61.7 (±59) days following the introduction of antiretrovirals. Lymph-node enlargement was the sole clinical manifestation. CD4 counts were &lt;100 cells/mm³in 50% of the patients, at the time of TB diagnosis. All but two patients were treated with prednisone, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Immune reconstitution syndrome; Tuberculosis; HAART; Lymph node enlargement; Paradoxical reaction.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500004

Immune responses to Leptospira infection: roles as biomarkers for disease severity
Provedor de dados: 55
Autores: Chirathaworn,Chintana; Kongpan,Sutthikarn.
Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Severity; Biomarker; Immune response.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077

Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
Provedor de dados: 55
Autores: Antonello,Vicente Sperb; Appel-da-Silva,Marcelo Campos; Kliemann,Dimas Alexandre; Santos,Breno Riegel; Tovo,Cristiane Valle.
OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis C; Coinfection; HAART; CD4; Immunological response.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500007

Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex
Provedor de dados: 55
Autores: Alves,Crésio; Souza,Thaisa; Meyer,Isadora; Toralles,Maria Betânia P.; Brites,Carlos.
Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surface-specific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HLA; Infectious diseases; Major histocompatibility complex.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200010

Immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine: a Phase III, open-label study of adults in Brazil
Provedor de dados: 55
Autores: Zerbini,Cristiano A.F.; Ribeiro dos Santos,Rodrigo; Jose Nunes,Maria; Soni,Jyoti; Li,Ping; Jain,Varsha K.; Ofori-Anyinam,Opokua.
Abstract The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines.In this Phase III, open-label study, we assessed the immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine (Fluarix™ Tetra) in Brazilian adults (NCT02369341). The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quadrivalent; Influenza; Vaccine; Immunogenicity; Safety; Brazil; Adults.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100063

Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine in elderly residents of a long-term care facility
Provedor de dados: 55
Autores: Valenzuela B.,M. Teresa; Altuzarra H.,Rogelio; Trucco A.,Olivia; Villegas R.,Rodrigo; Inostroza S.,Jaime; Granata S.,Paulo; Fleiderman V.,José; Maggi C.,Leonardo.
S. pneumoniae is a significant cause of community-acquired pneumonia in the elderly, and accounts for the majority of the pneumonia deaths among the elderly. We conducted this randomized double-blind study to evaluate the immune response to a 23-valent pneumococcal polysaccharide vaccine and the persistence of antibodies two years after the vaccination in an elderly population in Santiago, Chile. A total of 118 elderly nursing home residents received either the pneumococcal or a tetanus control vaccine. Serum samples were taken at enrolment, at two months, and at two years post-vaccination. Pre-vaccination anti-pneumococcal antibody geometric mean concentrations (GMC) were similar in both study groups, with increased levels of antibodies found only against...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Vaccine; Elderly; Immunogenicity; Antibodies.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300005

Immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type B conjugate vaccine (PRP-T) for primary and booster vaccinations
Provedor de dados: 55
Autores: Bracco Neto,Humberto; Colucci,Anete; Puccini,Rosana F.; Farhat,Calil K.
OBJECTIVE: To evaluate the immunogenicity of a combined DTPa-HB vaccine co-administered with Haemophilus influenzae type b conjugate vaccine (PRP-T) in Brazilian infants. MATERIAL AND METHODS: A prospective and open clinical study, in which 110 infants were immunized with a three-dose primary vaccination regime at two, four and six months of age and with a single booster vaccination. Blood samples were drawn immediately before the first dose, one month after the third dose, at the time of the booster dose and one month after the booster to assess seropositivity and antibody geometric mean titers (GMTs) of antibodies for diphtheria, tetanus, hepatitis B, Haemophilus influenzae type b and for the three pertussis antigens: Pertussis Toxin (PT), Filamentous...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaccines/immunology; Vaccines; Combined; Diphtheria-tetanus-acellular pertussis vaccines; Hepatitis B vaccines; Haemophilus vaccines.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500003

Immunoglobulin levels, cytology and microbiologic investigations of broncho-alveolar lavage in children with cystic fibrosis
Provedor de dados: 55
Autores: Petrova,Guergana; Strateva,Tanya; Ulevinov,Nikolay; Perenovska,Penka.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200027

Immunological synapses in infectious diseases
Provedor de dados: 55
Autores: Siqueira-Batista,Rodrigo; Geller,Mauro; Gomes,Andréia Patrícia.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100001

Immunomodulation: an idea from the past looks more promising than ever
Provedor de dados: 55
Autores: Jones,Thomas C.
Tipo: Info:eu-repo/semantics/article
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400009

Immunomodulatory properties of cell wall extract from Enterococcus faecalis CECT7121
Provedor de dados: 55
Autores: Sparo,Mónica; Delpech,Gastón; Batisttelli,Susana; Basualdo,Juan Ángel.
The aim of this study was to investigate the immunomodulatory properties of cell wall extract from Enterococcus faecalis CECT7121, measuring the induction of cytokines TNF-α, IL-6, IL-10 and IL-12 from human peripheral blood mononuclear cells (PBMCs). Cell wall extract was prepared from their growth in brain heart infusion broth (18 h, 35 °C). Subsequently, toxicity of the obtained cell wall extract was tested in Balb-C mice. PBMCs were isolated from buffy coats at the Blood Transfusion Service of Hospital Ramón Santamarina (Tandil, Argentina). PBMCs were purified using standard Ficoll-Paque gradient centrifugation. Aliquots of purified leukocytes were incubated at 37 °C for 24 h with heat-killed E. faecalis CECT7121 and cell wall extract. Concentrations...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: E. faecalis CECT7121; Cell wall; Immunomodulationa.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500551

Impact of A/H1N1 influenza in children at a Brazilian University Hospital
Provedor de dados: 55
Autores: Biondo,Gabriela Fontanella; Santana,João Carlos; Lago,Patrícia M.; Piva,Jefferson; Souza,Paulo Ricardo A.; Gaulke,Joana Genz; Sebben,Juliana M.
ABSTRACT  Background A/H1N1 influenza is a viral disease that affects a significant part of the population mainly in winter, leading to increased number of medical consultations, hospitalizations and consequently care spending in emergency.  Methods This is a case-series retrospective study, involving patients admitted to a tertiary hospital in southern Brazil in 2016 with a clinical diagnosis of acute respiratory infection of the influenza type and laboratory confirmation of influenza A/H1N1.  Results 64 patients were included, mostly male, median age of 48.3 months. Chronic underlying diseases were found in 73% of the patients, and these patients evolved to the most unfavorable outcome. About vaccination, of the 57 patients with an age range for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: H1N1 influenza; Emergency; Critical care; Children.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300219

Impact of human immunodeﬁciency virus infection on the clinical presentation and outcome of community-acquired pneumonia in hospitalized Nigerian adults: a multicenter case-control study
Provedor de dados: 55
Autores: Iroezindu,Michael Onyebuchi; Mbata,Godwin Chukwuemeka; Onyedum,Cajetan Chigozie; Chima,Emmanuel Iheke; Isiguzo,Godsent Chichebem.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100105

Impact of human schistosomiasis in sub-Saharan Africa
Provedor de dados: 55
Autores: Adenowo,Abiola Fatimah; Oyinloye,Babatunji Emmanuel; Ogunyinka,Bolajoko Idiat; Kappo,Abidemi Paul.
Schistosomiasis, a neglected tropical disease of poverty ranks second among the most widespread parasitic disease in various nations in sub-Saharan Africa. Neglected tropical diseases are causes of about 534,000 deaths annually in sub-Saharan Africa and an estimated 57 million disability-adjusted life-years are lost annually due to the neglected tropical diseases. The neglected tropical diseases exert great health, social and ﬁnancial burden on economies of households and governments. Schistosomiasis has profound negative effects on child development, outcome of pregnancy, and agricultural productivity, thus a key reason why the "bottom 500 million" inhabitants of sub-Saharan Africa continue to live in poverty. In 2008, 17.5 million people were treated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neglected tropical diseases Praziquantel Schistosomiasis; Sub-Saharan Africa.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200196

Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital
Provedor de dados: 55
Autores: Mello,Claudia Figueiredo; Negra,Marinella Della.
BACKGROUND: Bacterial pneumonia is one of the main causes of morbidity and mortality in patients infected by the human immunodeficiency virus (HIV). The main objective of this study was to evaluate the effect of macrolide therapy in combination with a beta-lactam based empiric regimen for inpatients with community-acquired pneumonia and HIV. METHODS: This is a retrospective cohort study of hospitalized patients. Adult patients who had received treatment with ceftriaxone or ceftriaxone plus clarithromycin were included. RESULTS: 76 patients met the inclusion criteria. Among baseline characteristics analyzed, only respiratory rate showed significant difference: patients who had received clarithromycin were more likely to have a respiratory rate &gt; 30/min...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Pneumonia; Macrolides; Mortality.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300014

Impact of piperacillin-tazobactam shortage on meropenem use: implications for antimicrobial stewardship programs
Provedor de dados: 55
Autores: Barber,Katie E.; Bell,Allison M.; King,S. Travis; Parham,Jason J.; Stover,Kayla R.
ABSTRACT Drug shortages pose a clear detriment to antimicrobial stewardship (AS) efforts. Our objective was to evaluate the effect of a piperacillin-tazobactam shortage on meropenem use, related costs, and associated changes in AS activity. A quasi-experimental quality improvement review compared adult patients receiving meropenem ≥72 h three months pre-shortage and three months during the shortage. 320 patients were included (pre-shortage: 103; shortage: 217). Baseline characteristics were similar, but the length of stay was slightly longer in pre-shortage [19 (11-32) days] versus shortage [16 (11-32) days] (p = 0.094). In pre-shortage and shortage, median days of therapy and estimated meropenem cost were 7 (5-11) and 7 (5-10) and $309.93...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Piperacillin; Meropenem; Pharmaceutical; Antimicrobial stewardship program.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600631

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients
Provedor de dados: 55
Autores: Batista-Neves,Susana; Quarantini,Lucas C.; Galvão-de Almeida,Amanda; Cardeal,Maurício; Lacerda,Acioly L.; Paraná,Raymundo; Reis de-Oliveira,Irismar; Bressan,Rodrigo A.; Miranda-Scippa,Angela.
The aim of our study was to determine the impact of psychiatric comorbidities on the health-related quality of life of HCV-infected patients. Assessment of clinical, socio-demographic and quality of life data of the patients followed up at a Hepatology unit was performed by using a standard questionnaire and the SF-36 instrument. Psychiatric diagnoses were confirmed by using the Mini International Neuropsychiatric Interview, Brazilian version 5.0.0 (MINI Plus). Evaluation using the MINI plus demonstrated that 46 (51%) patients did not have any psychiatric diagnosis, while 44 (49%) had at least one psychiatric diagnosis. Among patients with a psychiatric comorbidity, 26 (59.1%) had a current mental disorder, out of which 22 (84.6%) had not been previously...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mental disorders; Quality of life; HCV.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100009

Impact of respiratory infections by influenza viruses A and B in pediatrics patients from Federal University of Paraná, Brazil
Provedor de dados: 55
Autores: Coelho,M.C.; Tsuchiya,L.R.R.V.; Nogueira,M.B.; Pereira,L.A.; Takahashi,G.A.; Cruz,C.R.; Raboni,S.M.
The objective of the present study was to determine the impact of influenza virus on pediatric hospitalized patients. We retrospectively reviewed records of children with laboratory diagnoses, by cell culture and/or indirect immunofluorescence assay, of influenza virus seen in a period of 6 years. A total of 1,033 samples were analyzed, 45 (4.3%) of them being reactive to influenza virus. Thirty-one samples were positive to influenza A virus and 14 to influenza B. The frequency of hospitalization in intensive care and medical emergency was found to be high. Three (8.6%) patients died, two of them due to respiratory failure. Low frequency of influenza virus infection was observed in the study. The data suggest the need of more efficient epidemiological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Respiratory infection; Influenza virus; Indirect immunofluorescence; Children.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200010

Impact of the number of failed therapeutic regimes on the development of resistance mutations to HIV-1 in northeast Brazil
Provedor de dados: 55
Autores: Medeiros,Melissa Soares; Arruda,Érico Antônio Gomes; Guerrant,Richard Littleton; Brown,Christopher Cooley; Lima,Aldo Ângelo Moreira.
Highly-potent antiretroviral therapy is necessary to avoid viral replication in HIV patients; however, it can favor the appearance of resistance mutations. The mutations 41L, 67N, 70R, 210W, 215Y/F, 219E/Q, 44D and 118I are defined as nucleoside analogous mutations (NAMs), because they affect the efficacy of all nucleoside reverse transcriptase inhibitors (NRTI). The mutation most frequently associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) is 103N. 33W/F, 82A/F/L/T, 84V and 90M are called protease inhibitor resistance-associated mutations (PRAM), because they are associated with resistance to several protease inhibitors (PI). This study evaluated the development of resistance mutations and examine the susceptibility of HIV with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mutation; HIV-1; Failure therapy; Antiretrovirals; Resistance.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500002

Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
Provedor de dados: 55
Autores: Palchetti,Cecília Zanin; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Patin,Rose Vega; Teixeira,Patrícia Fonseca; Machado,Daisy Maria; Oliveira,Fernanda Luisa Ceragioli.
ABSTRACT  OBJECTIVE:  To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass.  METHODS:  A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal.  RESULTS:  Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Child; Body composition; Bone mineral density.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623

Implications of bacterial biofilms in chronic rhinosinusitis
Provedor de dados: 55
Autores: Tamashiro,Edwin; Antunes,Marcelo B.; Palmer,James N.; Cohen,Noam A.; Anselmo-Lima,Wilma T.
The recognition of sessile form of bacteria with particular features, known as biofilm, has given new insights to the understanding of pathogenesis of several chronic diseases, including Chronic Rhinosinusitis (CRS). In this article we review the main characteristics of biofilms, describe the current methods used to demonstrate biofilms in chronic rhinosinusitis and discuss the future directions of research in the field.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic rhinosinusitis; Biofilm; Planktonic bacteria.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300015

Importance of high IgG anti-Toxoplasma gondii titers and PCR detection of T. gondii DNA in peripheral blood samples for the diagnosis of AIDS-related cerebral toxoplasmosis: a case-control study
Provedor de dados: 55
Autores: Vidal,José E; Diaz,Adrián Vladimir Hernández; Oliveira,Augusto César Penalva de; Dauar,Rafi Felicio; Colombo,Fabio Antonio; Chioccola,Vera Lucia Pereira.
BACKGROUND: Cerebral toxoplasmosis (CT) continues to cause significant morbidity and mortality in human immunodeficiency virus (HIV)-infected patients in Brazil. In clinical practice, the initial diagnosis is usually presumptive and alternative diagnosis tools are necessary. Our objective was to evaluate whether the detection of high titers of IgG anti-Toxoplasma gondii and T. gondii DNA in blood samples are associated with the diagnosis of CT. METHODS: In this case-control study we included 192 patients with HIV-1 infection: 64 patients with presumptive CT (cases) and 128 patients with other diseases (controls). Blood samples to perform indirect immunofluorescense reaction (IFI) to detect anti-T. gondii IgG antibodies and polymerase chain reaction (PCR)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Cerebral toxoplasmosis; Polymerase chain reaction; Diagnosis; Acquired immunodeficiency syndrome; Brazil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400009

Improving hand hygiene compliance among healthcare workers: an intervention study in a Hospital in Guizhou Province, China
Provedor de dados: 55
Autores: Mu,Xia; Xu,Yan; Yang,Tingxiu; Zhang,Ji; Wang,Chong; Liu,Wei; Chen,Jing; Tang,Luyu; Yang,Huai.
Abstract  Objective Hand hygiene (HH) is a critical component for controlling hospital-acquired infection (HAI). The present study was designed to develop an intervention approach to improve compliance with HH among healthcare workers in a hospital setting.  Methods The HH intervention study was conducted in Guizhou Provincial People's Hospital, Guiyang, China and organized by its Department of HAI Management. It was an observational, prospective, quasiexperimental (before-after intervention) study. The study was divided into two phases: the baseline phase and the intervention phase. The investigative team included clinical monitoring staff and infection control practitioners who received a series of instructions on HH compliance, monitoring skills, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hand hygiene; Compliance; Hospital-acquired infection.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500413

Improving survival among Brazilian children with perinatally-acquired AIDS
Provedor de dados: 55
Autores: Matida,Luiza Harunari; Marcopito,Luiz Francisco; Succi,Regina Celia de Menezes; Marques,Heloisa Helena de Souza; Della Negra,Marinella; Grangeiro,Alexandre; Hearst,Norman.
Brazil was the first developing country to provide free, universal access to antiretroviral treatment for AIDS patients. The Brazilian experience thus provides the first evidence regarding the impact of such treatment on the survival of perinatally acquired AIDS cases in the developing world. MATERIAL AND METHODS: This retrospective cohort study used medical record reviews to examine characteristics and trends in the survival of a representative sample of 914 perinatally acquired AIDS cases in 10 Brazilian cities diagnosed between 1983 and 1998. RESULTS: Survival time increased steadily and substantially. Whereas half of the children died within 20 months of diagnosis at the beginning of the epidemic, 75% of children diagnosed in 1997 and 1998 were still...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency syndrome; Brazil; Human immunodeficiency virus; Pediatric; Perinatal transmission; Survival.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600005

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis
Provedor de dados: 55
Autores: Scheid,Liliane Alves; Mario,Débora Alves Nunes; Kubiça,Thaís Felli; Santurio,Janio Morais; Alves,Sydney Hartz.
In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to fluconazole. Our findings confirmed the ability of C. dubliniensis isolates to become resistant to fluconazole and indicated that this resistance was crossed with ketoconazole, itraconazole, ravuconazole and terbinafine. We also tested combinations of terbinafine, amphotericin B, itraconazole and voriconazole against both groups of isolates in a checkerboard assay. Surprisingly, most combinations evidenced indifferent interactions, and the best synergism...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Candida Antifungal agents Fluconazole Drug resistance; Fungal.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100014

In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae
Provedor de dados: 55
Autores: Nicodemo,A.C.; Mendes,C.M.F.; Oplustil,C.P.; Sinto,S.
In recent years, the level of resistance of S. pneumoniae to beta-lactam and/or macrolides has increased around the world including some countries in South America. Because of this resistance, it is necessary to test the therapeutic alternatives for treating this pathogen, including the newer quinolones. This study was carried out in order to compare the in vitro activity of fluoroquinolones gatifloxacin, levofloxacin and trovafloxacin, to penicillin G, amoxicillin, amoxicillin-clavulanate, cufuroxime sodium, ceftriaxone, azithromycin and clarithromycin, against 300 strains of S. pneumoniae. Of the 300 samples tested, 18.6% were not susceptible to penicillin (56 strains) and 7% (21 strains) were resistant to the second generation cephalosporin. Among the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: S. pneumoniae antimicrobial resistance; Susceptibility testing in vitro; Respiratory tract infections; Pneumococci.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200001

In vitro activity of non-bactericidal concentrations of polymyxin B in combination with other antimicrobials against OXA-23-producing carbapenem-resistant Acinetobacter baumannii
Provedor de dados: 55
Autores: Netto,Bárbara; Vieira,Bruno J.; Hermes,Djuli M.; Ribeiro,Vanessa B.; Zavascki,Alexandre P.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400022

In vitro activity of tigecycline, a new glycylcycline, tested against 1,326 clinical bacterial strains isolated from Latin America
Provedor de dados: 55
Autores: Gales,Ana C.; Jones,Ronald N.; Andrade,Soraya S.; Pereira,Andrea S.; Sader,Hélio S.
The in vitro activity of tigecycline (former GAR-936), a new semisynthetic tetracycline, was evaluated in comparison with tetracycline and other antimicrobial agents. MATERIAL AND METHODS: A total of 1,326 contemporary clinical isolates collected from the Latin American region were collected in 2000-2002 period and tested with microdilution broth according to the CLSI guidelines. The bacterial pathogens evaluated included Staphylococcus aureus (505), Streptococcus pneumoniae (269), coagulase-negative staphylococci (CoNS; 227), Haemophilus influenzae (129), Enterococcus spp. (80), Moraxella catarrhalis (54), beta-haemolytic streptococci (28), viridans group streptococci (26), and Neisseria meningitidis (8) RESULTS:Tigecycline demonstrated excellent activity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial susceptibility; Tigecycline; Latin America and SENTRY.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500001

In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil
Provedor de dados: 55
Autores: Denardi,Laura Bedin; Hoch Dalla-Lana,Bianca; Pantella Kunz de Jesus,Francielli; Bittencourt Severo,Cecília; Santurio,Janio Morais; Zanette,Régis Adriel; Alves,Sydney Hartz.
ABSTRACT The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC &gt; 2.0 mg/L). Voriconazole showed good activity against A. fumigatus and A. flavus strains, except for one clinical strain of A. fumigatus whose MIC was 4.0 mg/L. Posaconazole (≤0.25 mg/L) also showed appreciable activity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aspergillus flavus; Aspergillus fumigatus; Echinocandins; Azoles; Environmental; Susceptibility.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100030

In vitro antimicrobial activity of linezolid tested against vancomycin-resistant enterococci isolated in Brazilian hospitals
Provedor de dados: 55
Autores: Reis,Adriana O.; Cordeiro,Julio C. R.; Machado,Antonia M.O.; Sader,Helio S.
The emergence of vancomycin-resistant enterococci (VRE) has been described recently in Brazil. This is in contrast to the USA and Europe, where the VRE appeared in the late 1980s. The progressive increase in VRE isolation poses important problems in the antimicrobial therapy of nosocomial infections. Treatment options and effective antimicrobial agents for VRE are often limited and the possibility of transfer of vancomycin genes to other Gram-positive microorganisms continues. In the search for antimicrobial agents for multiresistant Gram-positive cocci, compounds such as linezolid and quinupristin/dalfopristin have been evaluated. The present study was conducted to evaluate the in vitro activity of the oxazolidinone linezolid and 10 other antimicrobial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Linezolid; Vancomycin-resistant enterococci; Quinupristin/dalfopristin-resistant Enterococcus faecium; Clonal dissemination; Nosocomial infection.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500002

In vitro antimicrobial activity of the aminoglycoside arbekacin tested against oxacillin-resistant Staphylococcus aureus isolated in Brazilian hospitals
Provedor de dados: 55
Autores: Cordeiro,Julio C. R.; Reis,Adriana O.; Miranda,Eliete A.; Sader,Helio S.
Arbekacin is an aminoglycoside used in Japan for treating infections caused by gentamicin and oxacillin-resistant S. aureus (ORSA). The objective of this study was to determine the in vitro antimicrobial activity of arbekacin against 454 clinical isolates of ORSA. The isolates were consecutively collected between January and July, 2000, from patients hospitalized in 8 Brazilian medical centers. The antimicrobial susceptibility testing was performed by disk diffusion method according to NCCLS recommendations. The vast majority of the isolates, 453 strains (99.8%), were considered susceptible to arbekacin based on the criteria proposed by the Requirements for Antibiotic Products of Japan. Only 1 isolate (0.2%) was classified as resistant. On the other hand,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Arbekacin; Oxacillin-resistant; ORSA; Antimicrobial resistance; Nosocomial Infections.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300005

In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1
Provedor de dados: 55
Autores: Assone,Tatiane; Kanashiro,Tatiana M.; Baldassin,Maira P.M.; Paiva,Arthur; Haziot,Michel E.; Smid,Jerusa; Oliveira,Augusto Penalva de; Fonseca,Luiz Augusto M.; Norris,Philip J.; Casseb,Jorge.
ABSTRACT  Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood.  Objective: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1.  Material and methods: From 610 Human T cell Leukemia Virus-infected patients of the Human T cell Leukemia Virus outpatient clinic from Institute of Infectious Diseases “Emilio Ribas” in São Paulo,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; HTLV-1; HIV-1; T-cell proliferation.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200106

In vitro fosfomycin activity in vancomycin-resistant Enterococcus faecalis
Provedor de dados: 55
Autores: Superti,Silvana; Dias,Cícero Armídio Gomes; d'Azevedo,Pedro Alves.
Enterococci are part of the endogenous flora of human beings, are naturally resistant to several classes of antimicrobials, and are able to acquire resistance with relative ease. Currently the vancomycin-resistant enterococci are spread all over the world and treatment options for infections caused by it are often extremely limited. We assessed 193 vancomycin-resistant Enterococcus faecalis isolates collected from four different hospitals in Porto Alegre for their susceptibility to fosfomycin using the E-test and agar diffusion. Fosfomycin proved to be active in vitro against the great majority of isolates, indicating that it is a valid option in the treatment of these infections.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococcus faecalis; Vancomycin-resistance; VRE; Fosfomycin.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200010

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13
Provedor de dados: 55
Autores: Coêlho,Zirlane Castelo B; Teixeira,Maria Jania; Mota,Erika Freitas; Frutuoso,Mércia Sindeaux; Silva,João Santana da; Barral,Aldina; Barral-Netto,Manoel; Pompeu,Margarida Maria L.
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production. We have expanded such observations evaluating the profile and kinetics of cytokines (IFN-γ, IL-12p70, IL-10, IL-13), chemokines (CCL5, CCL3, CCL4, CXCL10), and chemokine receptors (CCR1,CCR5, CXCR3, CCR4) in vitro L. amazonensis-stimulated of HV's PBMCs. HVs were divided in groups of high (HR) or low (LR) IFN-γ responders. In both groups, HR and LR, after L. amazonensis infection there was a predominance of IL-10 and IL-13 over IFN-γ production, while IL-12 was produced in similar amount. Regarding chemokines, a more striking...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania amazonensis; Interleukin-10; Interleukin-13.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500009

In vitro study of the effect of a probiotic bacterium Lactobacillus rhamnosus against herpes simplex virus type 1
Provedor de dados: 55
Autores: Khani,Soghra; Motamedifar,Mohammad; Golmoghaddam,Hossein; Hosseini,Hamideh Mahmoodzadeh; Hashemizadeh,Zahra.
BACKGROUND: Due to the emergence of drug resistance in herpes simplex virus type 1 (HSV-1), researchers are trying to find other methods for treating herpes simplex virus type 1 infections. Probiotic bacteria are effective in macrophage activation and may have antiviral activities. OBJECTIVE: This study aimed at verifying the direct effect of Lactobacillus rhamnosus, a probiotic bacterium, in comparison with Escherichia coli, a non-probiotic one, on HSV-1 infection, and determining its effect on macrophage activation for in vitro elimination of HSV-1 infection. METHODS: The above bacteria were introduced into HSV-1 infected Vero cells, and their effects were examined using both MTT and plaque assay. To determine macrophage activation against in vitro HSV-1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Probiotic; Lactobacillus rhamnosus; Herpes simplex virus type 1.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200004

In Vitro susceptibility of Gram-positive cocci isolated from skin and respiratory tract to azithromycin and twelve other antimicrobial agents
Provedor de dados: 55
Autores: Mendes,Caio M. F.; Sinto,Sumiko I.; Oplustil,Carmen Paz.
This study was conducted to evaluate the activity of azithromycin in comparison to 12 other antibacterial agents against recent isolates obtained consecutively from patients with respiratory tract or skin infections, from January to July, 2000. A total of 717 Gram-positive cocci were analyzed in this study and the following species were studied: Staphylococcus aureus (n=576), beta-hemolytic streptococci ( n=115), and Streptococcus pneumoniae (n=26). Susceptibility testing was carried out by the disk diffusion method and interpreted according to NCCLS breakpoints. The activity of azithromycin was compared to erythromycin, clindamycin, chloramphenicol, ciprofloxacin, ofloxacin, oxacillin, penicillin, ceftriaxone, tetracycline, trimethoprim/sulfamethoxazole,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gram-positive cocci; Azithromycin; Respiratory tract infection; Skin infection; Macrolide.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500005

In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid
Provedor de dados: 55
Autores: Múnera,Johanna Marcela Vanegas; Ríos,Ana María Ocampo; Urrego,Daniela Montoya; Jiménez Quiceno,Judy Natalia.
Abstract  Introduction Treatment of multidrug-resistant Gram-positive infections caused by Staphylococcus aureus remains as a clinical challenge due to emergence of new resistance mechanisms. Tedizolid is a next-generation oxazolidinone, recently approved for skin and soft tissues infections. We conducted a study to determine in vitro susceptibility to vancomycin, daptomycin, linezolid and tedizolid in MRSA clinical isolates from adult patients with skin and soft tissue infections.  Material and methods Methicillin-resistant S. aureus isolates were collected in three tertiary-care hospitals of Medellin, Colombia, from February 2008 to June 2010 as part of a previous study. Clinical characteristics were assessed by medical records and MIC values were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Skin and soft tissues infections; Tedizolid; Linezolid; Vancomycin; Daptomycin.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500493

Inability to work due to Chikungunya virus infection: impact on public service during the first epidemic in the State of Ceará, northeastern Brazil
Provedor de dados: 55
Autores: Bastos,Maria Luiza Almeida; Abreu,Francileudo Santos de; Silva Junior,Geraldo Bezerra da.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300248

Inactivation of Escherichia coli O157:H7 by essential oil from Cinnamomum zeylanicum
Provedor de dados: 55
Autores: Senhaji,Ouafae; Faid,Mohamed; Kalalou,Ichraq.
Escherichia coli O157:H7 is a pathogen strain, which causes hemorrhagic colitis, hemolytic uremic syndrome and thrombotic thrombocytopenic purpura in humans. The control of bacterial cells in foods is an important factor to reduce foodborne diseases due to E. coli O157:H7. Assays to inactivate E. coli O157:H7 were carried out by using the cinnamon oil obtained by steam distillation for 6 hours. When E. coli O157:H7 cells were incubated at 37°C for 2 hours in the presence of 0.025% of the essential oil from cinnamon, a dramatic decrease was observed in the viable counts (from 10(7) to 3.10(4) CFU/mL-1). In the presence of 0.05% of the oil, most of cells were killed after 30 min, suggesting that the antimicrobial activity of essential oil is bactericidal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial effect; Bactericidal; Essential oil; Cinnamon; E. coli O157:H7.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200013

Inadequate timing between corticosteroid and antibiotics applications increases mortality due to sepsis
Provedor de dados: 55
Autores: Fadel,Marcus Vinícius Telles; Repka,João Carlos; Cunha,Cláudio Leinig Pereira da; Leão,Maria Terezinha C.
This study tested the hypothesis that the use of corticosteroids prior to antibiotics can lower the mortality rate in severe infections by S. aureus or Gram-negative bacilli, using an animal model. This study was a prospective and controlled study, placed in a university laboratory. Seven hundred and sixty mice distributed into three groups (Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae infected). The interventions in each group were: I) infection control (intra-peritoneal); II) treatment solely with antibiotics (teicoplanin or amikacin); III) antibiotics administered prior to the corticosteroid (methylprednisolone); IV) antibiotics administered after the corticosteroid. Mortality in the E. coli group, subgroup I: 100%; subgroup II: 55%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenal cortex hormones; Antibiotics; Sepsis; Survival; Mice; Animals; Laboratory; Severe infection; Peritonitis; Shock; Endotoxin.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500013

Inadequate use of antibiotics and increase in neonatal sepsis caused by resistant bacteria related to health care assistance: a systematic review
Provedor de dados: 55
Autores: Silva,Ana Carolina Bueno; Anchieta,Leni Marcia; Lopes,Marianna Fischer de Paula; Romanelli,Roberta Maia de Castro.
ABSTRACT  Background Technologies and life support management have enhanced the survival of preterm infants. The immune system of newborns is immature, which contributes to the occurrence of healthcare-associated infections. The overlap of several conditions with neonatal sepsis and the difficulty of diagnosis and laboratory confirmation during this period result in a tendency to over-treat neonatal sepsis. The use of antimicrobial agents is a risk factor for multidrug-resistant bacterial infections. This work aimed to perform a systematic review of the relationship between inadequate use of antimicrobial agents and increase in neonatal sepsis related to healthcare assistance, due to bacterial resistance.  Methods Our population, exposition, comparison,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis Drug resistance; Microbial Infant; Newborn; Anti-infective agents.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400328

Inappropriate surgical chemoprophylaxis and surgical site infection rate at a tertiary care teaching hospital
Provedor de dados: 55
Autores: Rana,Devang Ashwinkumar; Malhotra,Supriya Deepak; Patel,Varsha Jitendra.
OBJECTIVES: This study aimed to analyze the pattern of surgical chemoprophylaxis, surgical site infection rate, and to check rationality of surgical chemoprophylaxis based on Kunin's criteria. MATERIALS AND METHODS: A prospective, observational study was performed on patients undergoing surgery, in a tertiary care teaching hospital. Data were collected in a pro-forma which included the patients' details, prescriptions from date of admission to discharge or any other outcome and operative notes. Surgical site infection as defined by Centre for Disease Control criteria was recorded. Rationality was assessed based on Kunin's criteria. RESULTS: Total 220 patients were enrolled over a period of one year. Mean hospital stay was 8.67 ± 5.17 days. A total of 2294...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kunin's criteria; Rationality; Surgical chemoprophylaxis; Surgical site infection (SSI).
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100008

Incidence and clinical characteristics of the infection by the Respiratory Syncytial Virus in children admitted in Santa Casa de São Paulo Hospital
Provedor de dados: 55
Autores: Pecchini,Rogério; Berezin,Eitan N.; Felício,Maria C. Calahani; Passos,Saulo D.; Souza,Maria Cândido O. de; Lima,Lourdes Rehder de Andrade Vaz de; Ueda,Mirthes; Matsumoto,Tokiko Kyomen; Durigon,Edison L.
The purpose of this study was to identify the rate of infections due to RSV and other viruses in children. In addition we have analyzed demographic data and clinical characteristics of the RSV-positive patients comparing with patients infected by other respiratory viruses. We also described the seasonality of the RSV occurrence in a hospital in São Paulo. Children below 5 years old admitted in Santa Casa de São Paulo Hospital between February 2005 and September 2006 due to acute respiratory infections (ARI) were included. A nasopharyngeal specimens were obtained with sterile No. 5 French feeding catheters as soon as possible (usually within 24 h). Specimens were kept refrigerated at 4ºC and transported to Adolfo Lutz Institute, where the indirect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; Bronchiolitis; RSV; Respiratory infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600006

Incidence and outcome of ventilator-associated pneumonia (our experience)
Provedor de dados: 55
Autores: Gvozdenović,Ljiljana; Kolarović,Jovanka; Šarkanović-Lukić,Mirka; Popović,Mira; Trivić,Svetlana.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600019

Incidence and risk factors of immune reconstitution inflammatory syndrome in HIV-TB coinfected patients
Provedor de dados: 55
Autores: Dibyendu,De; Sarkar,Rathindra Nath; Phaujdar,Sibaji; Bhattacharyya,Kuntal; Pal,Hare Krishna.
Tuberculosis is one of the leading causes of development of Immune reconstitution inflammatory syndrome (IRIS) in HIV patients receiving antiretroviral therapy (ART). OBJECTIVE: To determine the incidence of IRIS in HIV-TB coinfected patients, and to find out the possible risk factors associated with IRIS. MATERIALS AND METHODS: Study commenced with 96 patients adhered to standard antitubercular therapy (ATT) and ART without defaultering, and followed up for six months. RESULT: The mean (± SD) CD4 count and CD4 percentage at baseline was 59.16 (± 24.63) per mm³ and 4.59% (± 1.73) respectively. Only 18.75% developed IRIS after 57.05 (± 14.12) days of initiation of ART. Extrapulmonary tuberculosis was the most significant factor associated with IRIS (83.33%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Tuberculosis; Immune reconstitution inflammatory syndrome; CD4 lymphocyte count.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600009

Incidence and treatment of methicillin-resistant S. aureus infection in cystic fibrosis patients: a cohort study
Provedor de dados: 55
Autores: Bittencourt,Paloma Horejs; Pimentel,Carlos Sidney Silva; Bonfim,Bianca Sampaio; Marostica,Paulo José; Souza,Edna Lúcia.
Abstract In Brazil the knowledge about methicillin-resistant Staphylococcus aureus infection in cystic fibrosis patients is scarce. This study aimed to determine the incidence of respiratory tract colonization and the identification rates after a standardized treatment. A retrospective cohort was performed highlighting the history of respiratory colonizations between January 2008 and June 2015. Patients under the age of 21 years with cystic fibrosis confirmed by sweat test or genetic study receiving care at the outpatient clinics of a Teaching Hospital were included. The treatment consisted of trimethoprim/sulfamethoxazole, rifampicin, nasal mupirocin and chlorhexidine 2%. The mean follow-up period was of 22.2 months and those with ≥3 negative cultures...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Antibiotic therapy; Methicillin-resistant Staphylococcus aureus; Brazil; Pediatrics: therapy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100107

Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Santini-Oliveira,Marilia; Friedman,Ruth Khalili; Veloso,Valdilea Gonçalves; Cunha,Cynthia Braga; Pilotto,José Henrique; Marins,Luana Monteiro Spindola; João,Esaú Custódio; Torres,Thiago Silva; Grinsztejn,Beatriz.
Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Prevention of mother-to-child transmission; Adverse drug reaction; Toxicity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400372

Incidence of congenital toxoplasmosis among infants born to HIV-coinfected mothers: case series and literature review
Provedor de dados: 55
Autores: Campos,Flávia Alves; Andrade,Gláucia Manzan Queiroz de; Lanna,Antônio de Pádua Santos; Lage,Bruno Freitas; Assumpção,Maria Vitória Mourão; Pinto,Jorge A.
Introduction:There is a paucity of data on the occurrence of congenital toxoplasmosis in children born to mothers dually infected with HIV and Toxoplasma gondii.Objective:To evaluate aspects of the mother–infant pairs associated with vertical transmission of toxoplasmosis in women co-infected with HIV in a referral center for perinatally acquired infections in Belo Horizonte, Brazil.Methods:Descriptive study of HIV vertically exposed children, with congenital toxoplasmosis, followed at a referral center (cohort/Belo Horizonte). Prenatal and post-natal variables for the mother–infant pairs were evaluated. A literature review with no filtering for time and language was performed to identify reports of congenital toxoplasmosis in HIV vertically exposed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital toxoplasmosis; HIV; Co-infection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600609

Incidence of diarrhea in children living in urban slums in Salvador, Brazil
Provedor de dados: 55
Autores: Melo,Maria Clotildes N. de; Taddei,José A.A.C.; Diniz-Santos,Daniel R.; Vieira,Camilo; Carneiro,Nadya B.; Melo,Rita Franca; Silva,Luciana R.
Diarrhea remains a major health issue in developing countries, with high morbidity and mortality rates. Determining the incidence of acute diarrhea in children and its associated factors is crucial to the planning of preventive approaches. The objective of this study was to determine the incidence of diarrhea and to assess some relevant associated factors to it in children younger than 40 months living in two slums of Salvador, Brazil. This is the first prospective cohort, community-based study that was performed in two periurban slums of Salvador, Brazil. Eighty-four children younger than 40 months were randomly selected and visited every other day for one year. The chi-square test was used to evaluate the occurrence of diarrhea and its associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Children; Sewerage.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100019

Incidence of diarrhea: poor parental recall ability
Provedor de dados: 55
Autores: Melo,Maria Clotildes N. de; Taddei,José Augusto de A.C.; Diniz-Santos,Daniel R.; May,Daniel Simões; Carneiro,Nadya B.; Silva,Luciana R.
Several methodological issues may have an impact on the incidence rates of childhood acute diarrhea reported by community-based studies. This study was performed to assess the impact of parental recall ability and definition of diarrhea on the estimate of incidence of acute diarrhea. Eighty-four children younger than 40 months were randomly selected and visited every other day for four weeks and the occurrence of diarrhea was registered. On the last day of the study, another visit was performed and the informants were inquired about the occurrence of diarrhea during the previous four weeks. Data gathered during the four weeks were compared to those obtained on the last visit. Additionally, the informants' definition of diarrhea was investigated and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute diarrhea; Diarrhea in children; Diarrhea definition.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600009

Incidence of surgical site infection after craniotomy: comparison between three months and twelve months of epidemiological surveillance
Provedor de dados: 55
Autores: Torres,Silvana; Perdiz,Luciana Baria; Medeiros,Eduardo Alexandrino.
ABSTRACT  Objective: To determine the incidence of surgical site infection in patients undergoing craniotomy and to compare 12-month and 3-month post-discharge surveillance periods in terms of their impact on the incidence of surgical site infection in those patients.  Methods: This was a retrospective cohort study involving 173 adult patients submitted to “clean” craniotomy, with or without implants, during the six-month period, at a university hospital in the city of São Paulo, Brazil. All the patients were evaluated in the pre-, trans- and postoperative periods and were followed for 12 months to analyze the development of surgical site infections.  Results: Of the 173 patients undergoing craniotomy during the study period, 20 developed an surgical site...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Craniotomy; Surgical site infection; Surveillance.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500433

Incidence of Trypanosoma cruzi transmission through breastfeeding during acute experimental Chagas disease
Provedor de dados: 55
Autores: Martins,Luciamare Perinetti Alves; Castanho,Roberto Esteves Pires; Nogueira,Adriano Barbosa; Silva,Otavio Turolo da; Gusmão,Alex Silva de.
OBJECTIVE: To verify the incidence of T. cruzi transmission through breastfeeding during acute experimental Chagas' disease. METHODS: Fifteen female Swiss mice were mated and, after pregnancy confirmation, placed in individual cages. A few hours after birth, the females were inoculated with 0.1 mL of blood containing approximately 3 x 10(5) trypomastigote forms of Y strain of T. cruzi and continued breastfeeding for 25 days. RESULTS: In 142 offspring examined no infection through breast-feeding was observed. CONCLUSIONS: The low number of trypomastigote forms ingested by the newborn mice combined with biological and biochemical characteristics of blood trypomastigotes may explain the lack of transmission in this experiment.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Foods for pregnant and breastfeeding mothers; Chagas disease.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200004

Incidence of virulence determinants in clinical Enterococcus faecalis and Enterococcus faecium isolates collected in Bulgaria
Provedor de dados: 55
Autores: Strateva,Tanya; Atanasova,Daniela; Savov,Encho; Petrova,Guergana; Mitov,Ivan.
Abstract  Objectives To evaluate the prevalence of some virulence genes among 510 clinical Enterococcus spp. isolates and to assess the association of those genes with the species, infection site, and patient group (inpatients/outpatients).  Methods Adhesins genes (aggregation substances agg and asa1 of Enterococcus faecalis and Enterococcus faecium, respectively), enterococcal surface protein (esp), endocarditis-specific antigen A (efaA), collagen-binding proteins (ace/acm)); invasins (hyaluronidase (hyl) and gelatinase (gelE)); cytotoxines (activation of cytolysin (cylA) in E. faecalis); and modulators of the host immunity and inflammation (enhanced expression pheromone (eep) in E. faecalis) were detected by polymerase chain reaction.  Results The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococcus faecalis; Enterococcus faecium; Virulence genes; Prevalence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200127

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane S.; Veloso,Valdilea G.; Grinsztejn,Beatriz.
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately resulting in treatment failure and viral resistance. Elderly patients with HIV/AIDS (≥50 years) may have a different profile in terms of treatment modification due to higher incidence of comorbidities and polypharmacy. The aim of this study was to describe the incidence of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity (TOX-MOD) during the first year of treatment at the IPEC – FIOCRUZ HIV/AIDS cohort, Rio de Janeiro, Brazil, stratified by age. Demographic, clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Toxicity; Aging; Antiretroviral.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100034

Inconclusive HIV-1/2 results: how far should blood centers go?
Provedor de dados: 55
Autores: Bassetti-Soares,Eric; Andrade,Cristiane A.; Lima-Martins,Maria Virgínia C.; Pinho,Alcione M. de; Barezani,Ester; Carneiro-Proietti,Anna Bárbara F.
Tipo: Info:eu-repo/semantics/other
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300010

Inconsistent use of condoms in non-injecting illicit drug users
Provedor de dados: 55
Autores: Guimarães,Rafael Alves; Rodovalho,Aurélio Goulart; Fernandes,Inaina Lara; Lucchese,Roselma; Vera,Ivânia.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200220

Increased levels of IL-10, IL-12, and IFN- in patients with visceral leishmaniasis
Provedor de dados: 55
Autores: Khoshdel,A.; Alborzi,A.; Rosouli,M.; Taheri,E.; Kiany,S.; Javadian,M.H.
Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease. We evaluated plasma levels of IL-10, IL-12 and IFN- in 32 patients with active visceral lieshmaniasis, in 29 siblings of the patients and in 23 normal individuals in an endemic area to look for correlations between the clinical outcome of infection and the plasma cytokine levels. An analysis was made with a skin test and a quantitative sandwich enzyme immunoassay. Data were analyzed with the Mann Whitney test and the Kruskal Wallis test. The cytokine levels were significantly higher in the patients than in the control groups. We concluded that normalization of the plasma level of IFN- can serve as a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; Interleukin; Interferon.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100010

Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis
Provedor de dados: 55
Autores: Bessa,Thais Fontes; Cordeiro,Cynthia Azeredo; Gonçalves,Roberto Martins; Young,Lucy H.; Campos,Wesley R.; Oréfice,Fernando; Teixeira,Antônio L.
This study aimed to investigate the serum levels of the cytokine TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. 37 patients with TR and 30 subjects with positive serology for toxoplasmosis but without history and signs of uveitis were included in this study. Serum concentrations of TNF-α, sTNFR1, and sTNFR2 were determined by ELISA. Serum concentrations of TNF-α and sTNFR1 were similar in controls (mean ± SD median values; 56.57 ± 141.96 and 504.37 ± 163.87, respectively) and TR patients (mean ± SD values, 121.62 ± 217.56 and 511.15 ± 189.30, respectively). Serum concentrations of sTNFR2 were higher in the uveitis group when compared to the control group (respectively, mean ± SD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis Uveitis; TNF-alpha; Soluble TNF receptors.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600007

Increasing pathomorphism of pulmonary tuberculosis: an observational study of slow clinical, microbiological and imaging response of lung tuberculosis to specific treatment. Which role for linezolid?
Provedor de dados: 55
Autores: Manfredi,Roberto; Nanetti,Anna; Monte,Paola Dal; Calza,Leonardo.
During recent years, a progressive emerging of tuberculosis occurred, related to the overall increased age of general population, primary and secondary (iatrogenic) immunodeficiencies, the availability of invasive procedures, surgical interventions and intensive care supports, bone marrow and solid organ transplantation, and especially the recent immigration flows of people often coming from areas endemic for tuberculosis, and living with evident social-economical disadvantages, and with a reduced access to health care facilities. Since January 2006, at our reference centre we followed 81 consecutive cases of pulmonary tuberculosis, with 65 of them which remained evaluable for the absence of extrapulmonary complications, and a continuative and effective...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary tuberculosis; Microbiological assessment; Radiological assessment; Clinical-therapeutic issues; Selected antimicrobial treatments; Controlled observational study; Linezolid.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400012

Increasing prevalence and dissemination of invasive nontyphoidal Salmonella serotype Typhimurium with multidrug resistance in hospitalized patients from southern Brazil
Provedor de dados: 55
Autores: Reis,Rafael Oliveira dos; Souza,Margarida Neves; Cecconi,Maria Cristina Piccoli; Timm,Loeci; Ikuta,Nilo; Simon,Daniel; Wolf,Jonas Michel; Lunge,Vagner Ricardo.
ABSTRACT  Introduction: Nontyphoidal Salmonella serotypes are the main cause of human food-borne infection, including several hospitalization cases in the developing countries.  Aim: To detect the main serotypes and to characterize the antibiotic resistance of human non-enteric and enteric nontyphoidal Salmonella from clinical isolates in Brazil.  Methods: Salmonella serotypes were identified by microbiological and molecular methods. Susceptibility testing to antibiotics was performed by agar disk diffusion. Real-time PCRs were carried out for the detection of the genus Salmonella as well as serotypes Typhimurium and Enteritidis.  Results: A total of 307 nontyphoidal Salmonella were isolated from 289 different patients in a reference laboratory (LACEN-RS)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella; Antibiotic resistance; Typhimurium; Enteritidis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500424

Increasing prevalence of extended-spectrum-betalactamase among Gram-negative bacilli in Latin America: 2008 update from the Study for Monitoring Antimicrobial Resistance Trends (SMART)
Provedor de dados: 55
Autores: Villegas,Maria Virginia; Blanco,Manuel Guzmán; Sifuentes-Osornio,Jose; Rossi,Flávia.
OBJECTIVES: This analysis of the Study for Monitoring Antimicrobial Resistance Trends (SMART) evaluated the susceptibility patterns of Enterobacteriaceae in Latin America in 2008, with emphasis on susceptibility trends of E. coli and K. pneumoniae. METHODS: Clinical isolates were recovered from intra-abdominal infections (IAI) from 23 centers in 10 Latin American countries. Isolates were sent to a central laboratory for confirmation of identification, antimicrobial susceptibility and ESBL testing, following the Clinical Laboratory Standards Institute (CLSI) guidelines. RESULTS: Of 1,003 Gram-negative bacilli collected from intra-abdominal infections, E. coli and K. pneumoniae were the most commonly isolated organisms, and 26.8% of E. coli and 37.7% of K....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenems; Beta-lactamases; Gram-negative bacteria; Drug resistance; ESBL.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100007

Increasing rates of Clostridium difficile infection in Mexican hospitals
Provedor de dados: 55
Autores: Dávila,Laura Palau; Garza-González,Elvira; Rodríguez-Zulueta,Patricia; Morfín-Otero,Rayo; Rodríguez-Noriega,Eduardo; Vilar-Compte,Diana; Rodríguez-Aldama,Juan C.; Camacho-Ortiz,Adrián.
Abstract  Introduction The epidemiology of Clostridium difficile infection (CDI) has changed in the last two decades. There is a lack of information regarding incidence and severity of CDI, especially in the developing world.  Methods This was a retrospective and observational study from four hospitals of three Mexican cities. Patients were diagnosed with CDI when presented with loose stools and had at least one of the following tests positive: toxins assay, real-time PCR, or an endoscopic image compatible with pseudomembranous colitis. CDI was classified according to international guidelines. Demographic and clinical data as well as information regarding total hospital admissions, total length-of-hospital stay, and other variables related to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difficile; Hospital acquired infections; Hospital diarrhea; Infection rates.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500530

Indications of a new antibiotic in clinical practice: results of the tigecycline initial use registry
Provedor de dados: 55
Autores: Curcio,Daniel; Fernández,Francisco; Cané,Alejandro; Barcelona,Laura; Stamboulian,Daniel.
Tigecycline is the first of a new class of antibiotics named glycylcyclines and it was approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections. Notwithstanding this, tigecycline's pharmacological and microbiological profile which includes multidrug-resistant pathogens encourages physicians' use of the drug in other infections. We analyzed, during the first months after its launch, the tigecycline prescriptions for 113 patients in 12 institutions. Twenty-five patients (22%) received tigecycline for approved indications, and 88 (78%) for "off label" indications (56% with scientific support and 22% with limited or without any scientific support). The most frequent "off label" use was ventilator...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tigecycline; Off-label; Ventilator-associated pneumonia.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300007

Indinavir-associated toxicity mimicking urinary tuberculosis in a patient with AIDS
Provedor de dados: 55
Autores: Delfino,Vinicius Daher Alvares; Santiago,Natally Marques; Mocelin,Altair Jacob; Kunii,Luiz Fernando; Bortoliero,André Luiz.
This case reported to a patient with AIDS who presented persistent sterile leukocyturia and hematuria, lower back pain, bladder suffering symptoms, and renal papillary necrosis which were thought to be secondary to urinary tuberculosis but were demonstrated to be indinavir-associated side effects. The intention of this report is to remind medical professionals involved in the care of HIV+ patients of this possible association in order to avoid unnecessary investigation and to stress the need of careful periodical assessment of renal function and urinalysis in patients treated with indinavir.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hematuria; Indinavir; Kidney papillary necrosis; Tuberculosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100021

Induced sputum versus bronchoalveolar lavage in the diagnosis of pneumocystis jiroveci pneumonia in human immunodeficiency virus-positive patients
Provedor de dados: 55
Autores: Silva,Rosemeri Maurici da; Bazzo,Maria Luiza; Borges,Alessandra Abel.
Induced sputum is a useful technique for assessing airway inflammation, but its role in the diagnosis of lung disease in immunosuppressed patients needs further investigation. This study compared the use of induced sputum and BAL in the diagnosis of pneumocystosis, in HIV patients. From January 1, 2001, to December 30, 2002, HIV-positive patients older than 14 were evaluated at a hospital in Florianópolis, Santa Catarina, Brazil. Patients with respiratory symptoms for seven days or longer, with a normal or abnormal chest X-ray, and those without respiratory symptoms but with an abnormal chest X-ray, were included in the study. All patients were submitted to clinical, radiological and laboratory evaluation, after which induced sputum and bronchoscopy with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumocystosis; Induced sputum; Bronchoalveolar lavage.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600005

Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress
Provedor de dados: 55
Autores: Mukherjee,Debarati; Singh,Chingakham Brajakishor; Dey,Somaditya; Mandal,Supratim; Ghosh,Joydip; Mallick,Suvadip; Hussain,Aabid; Swapana,Ningombam; Ross,Samir Anis; Pal,Chiranjib.
Abstract In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmaniainfection. Various ginger spices of the Zingiberaceae family are widely used as spices, flavouring agents, and medicines in Southeast Asia because of their unique flavour as well as due to their medicinal properties. Zerumbone, a natural component of Zingiber zerumbet (L.) Smith, has been studied for its pharmacological potential as antiulcer, antioxidant, anticancer, and antimicrobial. In this study, we have shown that zerumbone could induce ROS mediated apoptosis in Leishmania donovani promastigotes and also found effective...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania donovani; Zingiber zerumbet; Zerumbone; Anti-leishmanial; ROS.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100048

Induction with ribavirin in a relapsing patient with chronic HCV hepatitis
Provedor de dados: 55
Autores: Ucciferri,Claudio; Mancino,Paola; Vignale,Francesca; Vecchiet,Jacopo; Falasca,Katia.
In this case, a new possible strategy for treatment of hepatitis C virus (HCV) relapsing patients is described. The target of anti-HCV therapy is sustained viral response, but strategies for improving sustained viral response in relapsing patients would be useful, and ribavirin is crucial for obtaining viral response. Six weeks of induction therapy with ribavirin were used to improve efficacy of standard combined antiviral therapy in a patient relapsing to standard therapy. In the present case, the patient had undergone a retreatment with the same regimen with the exception of the six-week induction period with ribavirin. Use of induction therapy with ribavirin in this case has allowed for a sustained viral response without prolonging the interferon...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Induction; Re-treatment; Sustained viral response; Hepatitis C virus.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300015

Ineffectiveness for infants of immunization of mothers with pneumococcal capsular polysaccharide vaccine during pregnancy
Provedor de dados: 55
Autores: Lopes,Claudia R.C.; Berezin,Eitan N.; Ching,Ting Hui; Canuto,Jaildo de Souza; Costa,Vanilda Oliveira da; Klering,Érika Monteiro.
Pneumococcal (Pnc) carriage is associated with pneumococcal diseases. Breast feeding and maternal vaccination may be a useful approach to prevent pneumococcal infection in young infants. We examined the risk of Pnc carriage by infants at six months of age after pneumococcal polysaccharide vaccination of pregnant women. We selected 139 pregnant woman. The woman were randomly allocated to receive 23-valent polysaccharide vaccines during pregnancy (Group 1) after pregnancy (Group 2) or not receive any vaccine (Group 3). Nasopharyngeal swabs were collected from the infants at three and six months of age. The infants were evaluated monthly during the first six months. We included 47 mothers in Group 1, 45 mothers in Group 2 and 47 mothers in Group 3....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumococcal diseases; Vaccine in pregnancy; Colonization.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200006

Infection and colonization by Staphylococcus aureus in a high risk nursery of a Brazilian teaching hospital
Provedor de dados: 55
Autores: Silva,Helisângela de Almeida; Abdallah,Vânia O. Steffen; Carneiro,Cláudia Lúcia; Gontijo Filho,Paulo P.
Neonates are susceptible to nosocomial infections due to immunological immaturity, prolonged hospital stay and the use of invasive procedures. We evaluated the incidence of infections and the prevalence of colonization by MRSA (Methicillin-resistant Staphylococcus aureus) and MSSA (Methilin-susceptible Staphylococcus aureus), as well as colonization risk factors. Staphylococcal infections were observed by analyzing medical records in the HICS (Hospital Infection Control Service) and the HRN (High Risk Nursery). Additionally, four inquiries concerning colonization prevalence were made for S. aureus, from January/2000 to December/2002. Clinical specimens from the nostrils, mouth and anus were cultivated in mannitol-salt agar plates and identification was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Neonates; Infection; Colonization and risk factors.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600005

Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias
Provedor de dados: 55
Autores: Vervloet,Letícia Alves; Marguet,Christophe; Camargos,Paulo Augusto Moreira.
This manuscript reviewed the literature on infection by Mycoplasma pneumoniae with emphasis on etiological aspects of childhood community-acquired pneumonias. Bibliographical research was carried out from Pubmed Medline, MDConsult, HighWire, LILACS, and direct research over the past 10 years with the following keywords: Mycoplasma pneumoniae, pneumonia, and childhood. Fifty-four articles were selected. Mycoplasma pneumoniae has a high incidence in childhood. Clinical presentation includes respiratory and extrarespiratory symptoms. Mycoplasma pneumoniae lung infection can be confused with viral or bacterial pneumonia and is unresponsive to beta-lactams. In addition, co-infections have been reported. Mycoplasma pneumoniae infection occurs in all age groups,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycoplasma pneumoniae; Pneumonia; Extrapulmonary findings; Diagnosis; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500012

Infection due to Borrelia burgdorferi most likely does not occur in Cuba
Provedor de dados: 55
Autores: Dessau,Ram B.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400021

Infection of the lymphatic system by Aureobasidium pullulans in a patient with erythema nodosum leprosum
Provedor de dados: 55
Autores: Morais,Orlando Oliveira de; Porto,Cláudia; Coutinho,Anglya Samara Silva Leite; Reis,Carmélia Matos Santiago; Teixeira,Marcus de Melo; Gomes,Ciro Martins.
Aureobasidium pullulans is a causal agent of phaeohyphomycosis, occasionally found in men and animals. As an agent of different opportunistic fungal processes, it may cause fungemia, systemic infections and abscesses in different viscera. This paper aims to report a case of a patient with infection of the lymphatic system by A. pullulans. A 23-year-old patient being treated for erythema nodosum leprosum presented a 60-day complaint of daily fever, hoarseness, odynophagia and weight loss. Laboratory tests showed pancytopenia with severe neutropenia, cervical adenomegaly and solid contrast uptake lesion in the oropharyngeal region. Due to neutropenia and sepsis the patient was initially treated with cefepime and vancomycin, but there was no clinical...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Pneumonia; Macrolides; Mortality.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300019

Infection with the Mycobacterium avium complex in patients without predisposing conditons: a case report and literature review
Provedor de dados: 55
Autores: Martins,Andrea Barral; Matos,Eliana Dias; Lemos,Antonio Carlos M.
Nontuberculous Mycobacteria (NTM), especially Mycobacterium avium-intracellulare complex (MAC), has been considered responsible for human disease, especially in HIV patients. Nevertheless, it has been diagnosed in immunocompetent elderly men, frequently with previous pulmonary disease: chronic obstructive lung disease (COPD), complications of tuberculosis, pulmonary fibrosis and bronchiectasis. We relate the case of a female patient, 51 years old, with continuously acid fast bacilli (AFB) smears and with three previous treatments, which were conducted at the multiresistant tuberculosis (MRTB) service. MAC was identified in the sputum culture, and she received treatment for one year. The posterior sputum exams were negative. The cavity lesions observed in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mycobacterium avium; Pulmonary disease; Bronchiectasis; Immunocompetent.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200009

Infections after shoulder arthroplasty are correlated with higher anesthetic risk score: a case-control study in Brazil
Provedor de dados: 55
Autores: Nagaya,Leonardo Hideto; Salles,Mauro José Costa; Takikawa,Lucas Sadawo Chagas; Fregoneze,Marcelo; Doneux,Pedro; Silva,Luciana Andrade da; Sella,Guilherme do Val; Miyazaki,Alberto Naoki; Checchia,Sergio Luiz.
ABSTRACT  Purposes: Shoulder arthroplasty (SA) has been performed by many years for the treatment of several conditions, including osteoarthritis and proximal humeral fractures following trauma. Surgical site infection (SSI) following Shoulder arthroplasty remains a challenge, contributing to increased morbidity and costs. Identification of risk factors may help implementing adequate strategies to prevent infection. We aimed to identify pre- and intra-operative risk factors associated with deep infections after Shoulder arthroplasty.  Methods: An unmatched case-control study was conducted to describe the prevalence, clinical and microbiological findings, and to evaluate patient and surgical risk factors for prosthetic shoulder infection (PSI), among 158...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Orthopedic infection; Hemiarthroplasty; Total shoulder arthroplasty; American Society of Anesthesiologists score; Risk factor; Pseudomonas aeruginosa.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600613

Infectious endocarditis caused by Nocardia sp.: histological morphology as a guide for the specific diagnosis
Provedor de dados: 55
Autores: Castelli,Jussara Bianchi; Siciliano,Rinaldo Focaccia; Abdala,Edson; Aiello,Vera Demarchi.
Nocardia is a rare opportunistic agent, which may affect immunocompromised individuals causing lung infections and exceptionally infective endocarditis (IE). There are few reports of IE caused by Nocardia sp., usually involving biological prostheses but rarely in natural valves. Its accurate microbiological identification may be hampered by the similarity with Rhodococcus equi and Corynebacterium spp. Here we report a case of native mitral valve IE caused by this agent in which the clinical absence of response to vancomycin and the suggestion of Nocardia sp. by histology pointed to the misdiagnosis of Corynebacterium spp. in blood cultures. The histological morphology can advise on the need for expansion of cultivation time and use of extra microbiological...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mitral valve endocarditis; Bacterial Nocardia infections.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400015

Infectious keratitis secondary to Histoplasma capsulatum: the first case reports in humans
Provedor de dados: 55
Autores: Arcieri,Enyr S.; Rocha,Ademir; Mendonça,Camila N.; Andreo,Eduardo G. V.; Finotti,Ioná G.A.; Furlanetto,Rafael L.; Arcieri,Rafael S.; Rocha,Flávio J.; Rizzo,Luiz V.
The authors report an unusual case of fungal keratitis caused by Histoplasma capsulatum in a male immunocompetent patient. PCR confirmed the presence of the fungus DNA in the material studied. To our knowledge this is the first reported case in humans described all over the world.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human; Keratitis; Histoplasma; Diagnosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600013

Infectious mononucleosis skin rash without previous antibiotic use
Provedor de dados: 55
Autores: Koufakis,Theocharis; Gabranis,Ioannis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500553

Infective endocarditis on a percoutaneous prosthetic aortic valve with associated glomerulopathy due to Granulicatella adjacens
Provedor de dados: 55
Autores: Quiroga,Borja; Arroyo,David; Verde,Eduardo; Eworo,Alia; Luño,Jose.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600020

Infectivity of Simulium damnosum s.l. and therapeutic coverage of ivermectin distribution 10 years post treatment around Owena Dam, Ondo state, Nigeria
Provedor de dados: 55
Autores: Akinsanya,Bamidele; Adewale,Babatunde; Adenusi,Adedotun; Lawal,ADimeji; Rahman,Olalekan.
ABSTRACT  Background: Studies related to infectivity status of insect vectors are seen as necessities in understanding the epidemiology of vector-borne diseases and planning effective control measures. This study assessed the infectivity ofSimulium damnosum s.l. around Owena River as well as evaluated therapeutic coverage of Ivermectin distribution in the area.  Method: Human landing sampling method was used to collect adult flies on human attractants from 07:00 to 18:00 for two consecutive days a month for three months (July 2016 - September 2016). Parity assessment was conducted to determine the age of fly populations. Parous flies were further dissected to detect the presence or absence ofOnchocerca larvae. Biting rates and transmission potentials were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infectivity; Simuliumdistribution; Ivermectin; Owena dam.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600410

Influence of ertapenem administration on the incidence of carbapenem-resistant Pseudomonas aeruginosa
Provedor de dados: 55
Autores: Lima,Ana Lúcia Lei Munhoz; Oliveira,Priscila Rosalba Domingos; Paula,Adriana P.; Zumiotti,Arnaldo Valdir.
Tipo: Info:eu-repo/semantics/other
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200001

Influence of iron deprivation on virulence traits of mycobacteria
Provedor de dados: 55
Autores: Pal,Rahul; Hameed,Saif; Sharma,Sharda; Fatima,Zeeshan.
ABSTRACT Novel strategies to combat the ever increasing burden of drug resistance in Mycobacterium tuberculosis (MTB) causing tuberculosis (TB) remains a global concern. The ability of MTB to sense and adapt to restricted iron conditions in the hostile environment is essential for their survival and confers the basis of their success as dreadful pathogen. The striking and clinically relevant virulence trait of MTB is its ability to form biofilms and adhere to the host cells. The present study elucidated the effect of iron deprivation on biofilm formation and cell adherence of Mycobacterium smegmatis, a non-pathogenic surrogate of MTB. Firstly, we showed that iron deprivation leads to enhanced cell sedimentation rate and altered colony morphology depicting...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Iron; Morphology; Biofilm; Anti-TB drugs.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600585

Influence of microbiome species in hard-to-heal wounds on disease severity and treatment duration
Provedor de dados: 55
Autores: Chudobova,Dagmar; Cihalova,Kristyna; Guran,Roman; Dostalova,Simona; Smerkova,Kristyna; Vesely,Radek; Gumulec,Jaromir; Masarik,Michal; Heger,Zbynek; Adam,Vojtech; Kizek,Rene.
ABSTRACT  BACKGROUND:  Infections, mostly those associated with colonization of wound by different pathogenic microorganisms, are one of the most serious health complications during a medical treatment. Therefore, this study is focused on the isolation, characterization, and identification of microorganisms prevalent in superficial wounds of patients (n = 50) presenting with bacterial infection.  METHODS:  After successful cultivation, bacteria were processed and analyzed. Initially the identification of the strains was performed through matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on comparison of protein profiles (2-30 kDa) with database. Subsequently, bacterial strains from infected wounds were identified by both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial strains; MALDI-TOF; Sequencing; Superficial wounds.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600604

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons
Provedor de dados: 55
Autores: Machado,Clarisse M.; de Souza,Ana Carolina Mamana Fernandes; Romano,Camila Malta; dos Santos Freire,Wilton; Costa,Ângela Aparecida; Figueiredo,Walter Manso; Pannuti,Cláudio S.; Luna,Expedito J.A.
ABSTRACT  Introduction Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than outpatients. Yearly vaccination with trivalent or quadrivalent vaccines is the main strategy to control influenza.  Objectives Determine the clinical and molecular characteristics of influenza A and B infections in children and adolescents with influenza-like illness (ILI).  Methods: A cohort of outpatient children and adolescents with ILI was followed for 20 months. Influenza was diagnosed with commercial multiplex PCR platforms.  Results: 179 patients had 277 episodes of ILI, being 79 episodes of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza; Outpatient; Children; Vaccine; Lineages; Phylogeny; Cohort.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100073

Influenza in Yucatan in 2018: Chronology, characteristics and outcomes of ambulatory and hospitalized patients
Provedor de dados: 55
Autores: Mendez-Dominguez,Nina I.; Bobadilla-Rosado,Luis O.; Fajardo-Ruiz,Lizbeth S.; Camara-Salazar,Andrea; Gomez-Carro,Salvador.
ABSTRACT  Introduction: Influenza season is expected between October and February in the northern hemisphere, including Mexico. Previous studies suggested that transmission peak may occur earlier in Yucatan, a state in southeast Mexico.  Objectives: (a) Describe the seasonality of 2018 influenza cases seen at O´Horan hospital, statewide, and nationwide; (b) analyze the characteristics, clinical manifestations and outcomes of ambulatory and hospitalized patients; (c) analyze fatal outcomes occurrence among vaccinated and unvaccinated individuals.  Methods: Retrospective analytic cohort of all confirmed influenza cases assisted at O´Horan hospital during 2018, along with a chronologic graphic description of the statewide epidemic curve from the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Influenza virus; Infection; Hospitalization; Signs and symptoms.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500358

Initial evaluation of universal immunization with a single dose against hepatitis A virus in Central Brazil
Provedor de dados: 55
Autores: Brito,Wagner Izidoro de; Alves-Junior,Eduardo Rodrigues; Oliveira,Rode Martinho de; Souto,Francisco José Dutra.
ABSTRACT Vaccination against the hepatitis A virus (HAV) administered in two doses has been used effectively in universal child immunization programs in several countries. A single-dose vaccination was adopted in some low-income countries in an attempt to reduce costs without losing effectiveness. In 2014, single-dose universal vaccination was introduced in Brazil for children aged two years. Since such strategy is still not universally accepted, its efficacy should be compared to the two-dose strategy. To assess the humoral response after the single-dose HAV vaccination schedule, a cross-sectional study was conducted in Primavera do Leste, in Mato Grosso state, Central Brazil, including 265 children vaccinated through the National Immunization Program....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis A vaccine; Single-dose schedule; Anti-HAV; Dried blood spot testing; Immunization programs.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300166

Innate immune immunity and viral therapy of cancer
Provedor de dados: 55
Autores: Barber,Glen N.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500025

Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C
Provedor de dados: 55
Autores: Fathy,Amal; Eldin,Mohamed Mohy; Metwally,Lobna; Eida,Mohamed; Abdel-Rehim,Marwa; Esmat,Gamal.
Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors. A minority of the natural killer cells are CD56bright, and function as an important source of immune-regulatory cytokines. Shifts of these subsets have been reported in patients with chronic hepatitis C virus infection. We sought to investigate the shift of natural killer subsets among Egyptian patients with chronic HCV and to analyze the influence of interferon therapy on this shift. We applied a flow cytometric analysis of peripheral blood natural killer subsets for 12 interferon-untreated and 12 interferon-treated patients with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Natural killer cells; Natural killer subsets; Chronic hepatitis C; Innate immunity; Interferon.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400015

Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG + 874 A&amp;gt;T polymorphism
Provedor de dados: 55
Autores: Carneiro,Valdirene Leão; Bendicho,Maria Teresita; Santos,Rosalina Guedes; Casela,Marilda; Netto,Eduardo M.; Mota,Scarlet Torres Moraes; Pina,Iza Cristina Araújo; Nascimento,Roberto Meyer; Freire,Songeli Menezes; Barbosa,Theolis.
ABSTRACT  Introduction Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG + 874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG + 874 A/T polymorphism on interferon-gamma test performance.  Methods Patients diagnosed with pulmonary tuberculosis (75), volunteers with positive tuberculin skin test (70) and healthy volunteers with negative tuberculin skin test and no history of contact with tuberculosis (57) were evaluated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis infection; Genetic variation; Sensitivity.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300202

Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis infection among HIV patients in Brazil
Provedor de dados: 55
Autores: Kussen,Gislene Maria Botão; Dalla-Costa,Libera Maria; Rossoni,Andrea; Raboni,Sonia Mara.
Abstract  Setting Patients HIV+ attending in a reference clinic, Southern Brazil.  Objective To compare the interferon-gamma-release assay (IGRA – QuantiFERON® TB Gold In-Tube) with the tuberculin skin test (TST – PPD-Rt 23) for latent tuberculosis infection (LTBI) in patients with HIV.  Design Cohort study. Patients were simultaneously submitted to the TST and blood collection for the IGRA.  Results A total of 140 subjects were included. Nine (6.4%) were IGRA+/TST+, 12 (8.6%) were IGRA+/TST−, 4 (3%) were IGRA−/TST+, and 115 (82%) IGRA−/TST−. There was poor agreement between tests (kappa = 0.2), and no correlation between these results and CD4+ T lymphocyte counts. During follow-up, one patient with negative results on both tests died from sepsis, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Immunological tests; Immunocompromised patients.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100069

Interleukin-10 gene polymorphism (-1082G/A) and allergy to efavirenz in patients infected with human immunodeficiency virus
Provedor de dados: 55
Autores: Rodrigues,Raphael de Oliveira; Carvalho,Paulo Germano de; Arruda,Érico Antônio Gomes de; Rabenhorst,Silvia Helena Barem; Silva,Silvia Fernandes Ribeiro da; Ribeiro,Ilana Farias; Lima,Denise Girão Limaverde; Nagao-Dias,Aparecida Tiemi.
The aim of the present study was to investigate the association between polymorphism in the interleukin-10 gene promoter at position -1082 in human immunodeficiency virus-infected patients who had presented allergic reaction due to efavirenz. The study included 63 patients treated at the Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil. Twenty-one patients who had presented allergic reaction to efavirenz were compared to 42 patients with no allergic reaction following exposure to this drug. Blood samples were collected for DNA extraction and submitted to the restriction fragment length polymorphism - polymerase chain reaction technique. The -1082AA genotype was significantly more frequent in allergic patients as compared to non-allergic...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Drug allergy; Polymorphism; IL-10.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400445

Interleukin-12 gene adjuvant increases the immunogenicity of virus-like particles of human papillomavirus type 16 regional variant strain
Provedor de dados: 55
Autores: Wei,Lanlan; Chu,Ming; Zhang,Qingmeng; Wang,Yan; Shang,Qinglong; Zhang,Yunyan; Zhang,Guangmei.
Objectives:To analyze the immunogenicity of virus-like particles (VLP) of human papillomavirus type 16 (HPV16) isolated in East China and the adjuvant potential of interleukin-12 (IL-12).Methods:The variant HPV16 L1VLP expressed in sf9 insect cells were purified with cesium chloride gradient centrifugation. BALB/c mice were vaccinated with VLP (L1N), VLP with Freund's adjuvant (L1A) or VLP with IL-12 recombinant plasmid (L1P). HPV16 VLP specific IgG and IFN-γ level in the serum were detected by ELISA, and the percentage of CD4+ and CD8+ in spleen cells was detected with flow cytometry.Results:The titers of serum IgG antibodies in vaccinated groups were higher than in negative control and the serum antibodies mainly recognized conformation-dependent HPV16...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cervical cancer; Human papillomavirus type 16; Virus-like particle; Cellular immunity; IL-12.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100065

Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
Provedor de dados: 55
Autores: Façanha,Mônica C.; Gondim,Argina M.B.; Pinheiro,Valéria G.F.; Barroso,Elizabeth C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A.M.
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p &lt; 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Bioavailability of antimycobacterial drugs; Intestinal barrier function; Rifampin; Isoniazid and pyrazinamide.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011

Intestinal microbiota of patients with bacterial infection of the respiratory tract treated with amoxicillin
Provedor de dados: 55
Autores: Monreal,Maria Tereza Ferreira Duenhas; Pereira,Paulo Câmara Marques; Lopes,Carlos Alberto de Magalhães.
The intestinal tract harbors a huge diversity of metabolically-active aerobic and anaerobic bacteria that interact, forming a complex ecosystem. This microbiota has an important role in human metabolism, nutrition, immunity, and protection against colonization by pathogenic microorganisms. Several factors can influence the intestinal microbiota; these include age, diet, inflammatory and infectious processes, and the use of antimicrobials. We investigated the influence of bacterial infection of the respiratory tract and of amoxicillin therapy on the normal intestinal microbiota of patients. Bacterial infectious processes affecting the respiratory tract were found to influence the intestinal microbiota, significantly decreasing the number of colony-forming...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intestinal microbiota; Bifidobacterium; Bacteroides; Lactobacillus.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400005

Intestinal microsporidiosis in a reference center
Provedor de dados: 55
Autores: Costa,Loredana Nilkenes Gomes da; Marson,Fernando Augusto de Lima; Teixeira,Angela Terezinha Lauand Sampaio; Sales,Célia Regina Mendes; Levy,Carlos Emílio.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600021

Intestinal parasitic infections in renal transplant recipients
Provedor de dados: 55
Autores: Azami,Mehdi; Sharifi,Mehran; Hejazi,Sayed Hossein; Tazhibi,Mehdi.
The impact of intestinal parasitic infection in renal transplant recipients requires careful consideration in the developing world. However, there have been very few studies addressing this issue in Iran. This study was conducted to determine the prevalence of intestinal parasitic infections in renal transplant recipients in Iran. Stool specimens from renal transplant recipients and control groups were obtained between June 2006 and January 2007. The samples screened for intestinal parasitic infections using direct smear, formalin-ether sedimentation, Sheather's flotation and modified Ziehl-Neelsen staining methods. Out of 150 renal transplant recipients, 33.3% (50), and out of 225 control group, 20% (45) were infected with one or more type of intestinal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intestinal parasites; Renal transplant recipients; Prevalence.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100004

Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis
Provedor de dados: 55
Autores: Pinheiro,Valéria G. F.; Ramos,Lysiane M. A.; Monteiro,Helena S. A.; Barroso,Elizabeth C.; Bushen,Oluma Y.; Façanha,Mônica C.; Peloquin,Charles A.; Guerrant,Richard L.; Lima,Aldo A. M.
Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary tuberculosis; Intestinal permeability; Rifampin and isoniazid intestinal malabsorption; M. tuberculosis resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600003

Intrathecal use of amikacin: a case report
Provedor de dados: 55
Autores: Barrou,L.; Charra,B.; Hachimi,A.; Idali,B.; Benslama,A.; Motaouakkil,S.
Meningitis caused by Acinetobacter baumannii is rare and are mostly hospital acquired after neurosurgical procedure. We report a case of a 40-year old man was admitted to the intensive care unit due to subarachnoid haemorrhage. Our patient developed a ventriculitis due to A.baumannii treated successfully with sulbactam IV and intrathecal amikacin.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amikacin; Intrathecal; Nosocomial meningitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600022

Intrauterine fetal death due to congenital cytomegalovirus infection
Provedor de dados: 55
Autores: Licci,Stefano.
Tipo: Info:eu-repo/semantics/report
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500567

Intravenous azithromycin plus ceftriaxone followed by oral azithromycin for the treatment of inpatients with community-acquired pneumonia: an open-label, non-comparative multicenter trial
Provedor de dados: 55
Autores: Rubio,Fernando G.; Cunha,Clóvis A.; Lundgren,Fernando L.C.; Lima,Maria P.J.S.; Teixeira,Paulo J.Z.; Oliveira,Julio C.A.; Golin,Valdir; Mattos,Waldo L.L.D.; Mählmann,Herbert K.; Moreira,Edson D.; Jardim,Jose R.; Silva,Rodney L.F.; Silva,Patricia H.B.
Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome. This is an open-label, non-comparative study with the purpose of evaluating efficacy, safety, and tolerability levels of IV azithromycin (IVA) and IV ceftriaxone (IVC), followed by oral azithromycin (OA) for the treatment of inpatients with mild to severe CAP. Eighty-six patients (mean age 56.6 ± 19.8) were administered IVA (500mg/day) and IVC (1g/day) for 2 to 5 days, followed by AO (500mg/day) to complete a total of 10 days. At the end of treatment (EOT) and after 30 days (End of Study - EOS) the medication was evaluated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community acquired infections; Pneumonia; Anti-bacterial agents; Macrolide ketolides; Azithromycin.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300008

Intraventricular mass in a patient with AIDS
Provedor de dados: 55
Autores: Sousa,Alexandra; Araújo,Vítor; Maciel,Maria Júlia.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100020

Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis
Provedor de dados: 55
Autores: Carvalho-Dias,Viviane Maria Hessel; Sola,Caroline Bonamin Santos; Cunha,Clóvis Arns da; Shimakura,Sílvia Emiko; Pasquini,Ricardo; Queiroz-Telles,Flávio de.
Invasive aspergillosis (IA) currently is an important cause of mortality in subjects undergoing hematopoietic stem cell transplants (HSCT) and is also an important cause of opportunistic respiratory and disseminated infections in other types of immunocompromised patients. We examined the medical records of 24 cases of proven and probable invasive aspergillosis (IA) at the Hospital de Clinicas of the Federal University of Parana, Brazil, from January 1996 to October 2006. During this period occurred a mean of 2.2 cases per year or 3.0 cases per 100 HSTC transplants. There was a significant relationship between structural changes in the bone marrow transplant (BMT) Unit and the occurrence of IA cases (p=0.034, relative risk (RR) = 2.47). Approximately 83% of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Invasive aspergillosis; Transplant recipients; Immunocompromised.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500008

Invasive bacteria isolates from children with cerebral shunt and pattern of antimicrobial drug susceptibility in an Iranian referral pediatrics center
Provedor de dados: 55
Autores: Shayanfar,Nasrin; Mohammadpour,Masoud; Haghi-Ashtiani,Mohammad Taghi; Nejat,Farideh; Farahani,Narges Node; Abedini,Mina; Rezaei,Nima.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400020

Invasive intracranial aspergillosis spread by the pterygopalatine fossa in an immunocompetent patient
Provedor de dados: 55
Autores: Xiao,Anqi; Jiang,Shu; Liu,Yi; Deng,Kaihong; You,Chao.
Aspergillosis of the central nervous system (CNS) is an uncommon infection, mainly found in immunocompromised patients but rarely seen among immunocompetent patients. Herein we describe a 57 year-old immunocompetent man who suffered intracranial aspergillosis spread by the pterygopalatine fossa (PPF) following a tooth extraction. Based on magnetic resonance imaging (MRI) characteristics, in this report we focus on the spreading routes of CNS aspergillosis via communicative structures of the PPF, the relationship between clinical manifestations and the locations of the lesion, and propose a therapeutic strategy to improve the prognosis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Aspergillosis; Pterygopalatine fossa; Magnetic resonance imaging.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200016

Involvement of nitric oxide and its up/down stream molecules in the immunity against parasitic infections
Provedor de dados: 55
Autores: Nahrevanian,Hossein.
Nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions and signaling pathways. The NO synthase (NOS) enzyme family consists of three major isoforms, which convey variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxicity. This family of enzymes are generally classified as neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). Increased levels of NO are induced from iNOS during infection; while eNOS and nNOS may be produced at the baseline in normal conditions. An association of some key cytokines appears to be essential for NOS gene regulation in the immunity of infections. Accumulating evidence indicates that parasitic diseases are commonly associated with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: INOS; Nitric oxide; NO; Immunity; Helminth; Parasite; Protozoa.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600010

Is an HIV vaccine possible?
Provedor de dados: 55
Autores: Wilson,Nancy A.; Watkins,David I.
The road to the discovery of a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty years. Most vaccines are developed by inducing neutralizing antibodies against the target pathogen or by using attenuated strains of the particular pathogen to engender a variety of protective immune responses. Unfortunately, simple methods of generating anti-HIV antibodies have already failed in a phase III clinical trial. While attenuated SIV variants work well against homologous challenges in non-human primates, the potential for reversion to a more pathogenic virus and recombination with challenge viruses will preclude the use of attenuated HIV in the field. It has been exceedingly frustrating to vaccinate for HIV-specific...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Vaccine; Challenges.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400013

Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case-control studies
Provedor de dados: 55
Autores: Majidiani,Hamidreza; Dalvand,Sahar; Daryani,Ahmad; Galvan-Ramirez,Ma de la Luz; Foroutan-Rad,Masoud.
ABSTRACT  Introduction: The global protozoan parasite, Toxoplasma gondii, infects many warm-blooded animals and humans by employing different transmission routes. There have been some recent studies on the probable relevance of infectious agents and diabetes. Therefore, we conducted a systematic review and meta-analysis to identify the possible association between chronic toxoplasmosis and diabetes mellitus.  Methods: This study was conducted following the general methodology recommended for systematic reviews and meta-analysis. Nine English literature databases (Google scholar, PubMed, Scopus, Web of science, Science Direct, Ovid, ProQuest, IngentaConnect, and Wiley Online Library) were searched, up to January 2016. Random effects model was used to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasma gondii; Diabetes mellitus; Systematic review; Meta-analysis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600605

Is community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) an emerging pathogen among children in Brazil?
Provedor de dados: 55
Autores: Paternina-de la Ossa,Rolando; Prado,Seila Israel do; Cervi,Maria Célia; Lima,Denissani Aparecida Ferrari dos Santos; Martinez,Roberto; Bellissimo-Rodrigues,Fernando.
ABSTRACT  Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is spreading worldwide, but little is known about the epidemiology of this pathogen in Brazil.  Objective: To evaluate clinical and microbiological features of children with S. aureus infections admitted to a university hospital.  Methods: This was a cross-sectional study evaluating the potential risk factors for CA-MRSA, and a retrospective cohort evaluating in-hospital clinical outcomes. To include patients with both community and hospital-associated infections, we screened the results of the microbiological laboratory tests from January 1, 2012, to December 31, 2016. According to the phenotype, we classified the isolates in Methicillin-Susceptible S. aureus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; CA-MRSA; Epidemiology; Clinical features; Children; Susceptibility profile.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500371

Is hepatitis C virus a cause of idiopathic dilated cardiomyopathy? A systematic review of literature
Provedor de dados: 55
Autores: Reis,Francisco José Farias Borges dos; Sousa,Tiago Almeida de; Oliveira,Manoela S.; Dantas,Ney; Silveira,Martha; Braghiroly,Maria Ignês Freitas Melro; Paraná,Raymundo.
Recent studies have suggested that some patients with idiopathic dilated cardiomyopathy (IDC) are also afflicted with insidious forms of viral myocarditis. Participation of hepatitis C virus (HCV) in this process has been postulated. The objective of this study was to evaluate a possible association between hepatitis C virus and idiopathic dilated cardiomyopathy. Systematic review of the literature using electronic databases (MEDLINE, EMBASES, LILACS and COCHRANE) for the period from 1995 to 2005, limited to papers published in English, Spanish and Portuguese. Sixty-two papers were found, of which six were in accordance with the proposed methodology. After selection, the articles were classified by quality of data and number of variables studied. Most of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Idiopathic dilated cardiomyopathy; Hepatitis C virus; Systematic review.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300009

Is it acalculous cholecystitis or reactive/viral pericholecystits in acute hepatitis?
Provedor de dados: 55
Autores: Debnath,Jyotindu; Mathur,Ankit.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600021

Is it time for Brazil to prioritize TB preventive therapy for all people living with HIV?
Provedor de dados: 55
Autores: Maciel,Ethel L.; Prado,Thiago N. do; Andrade,Kleydson Bonfim; Golub,Jonathan E.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100074

Is nosocomial Escherichia coli bacteremia a predictive risk factor for mortality?
Provedor de dados: 55
Autores: Tuon,Felipe F.; Rocha,Jaime L.; Guadagnin,Fernanda A.; Alves,Márcia S.
The objective of this study was to determine risk factors associated with mortality in patients with nosocomial Escherichia coli bacteremia from January 2009 to January 2011. In a retrospective study the medical records of 88 patients over 18 years with nosocomial bacteremia caused by E. coli were analyzed. In univariate analysis several risk factors, including chronic renal failure, altered mental status, leukocytosis, and higher Charlson index of comorbidities were associated with mortality. In multivariate analysis only altered mental status remained independently associated with mortality. Mental confusion can be a risk factor for mortality in patients with E. coli bacteremia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nosocomial bacteremia; Escherichia coli; Mortality; Antibiotic therapy.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100092

Is Visceral Leishmaniasis the same in HIV-coinfected adults?
Provedor de dados: 55
Autores: Henn,Guilherme Alves de Lima; Ramos Júnior,Alberto Novaes; Colares,Jeová Keny Baima; Mendes,Lorena Pinho; Silveira,João Gabriel Colares; Lima,Anderson Alberto Façanha; Aires,Bárbara Pontes; Façanha,Mônica Cardoso.
ABSTRACT  Introduction: Visceral Leishmaniasis is the most severe form of disease caused by the Leishmania donovani complex, with significant morbidity and mortality in developing countries. Worse outcomes occur among HIV-positive individuals coinfected with Leishmania. It is unclear, however, if there are significant differences on presentation between Visceral Leishmaniasis patients with or without HIV coinfection.  Methods: We reviewed medical records from adult patients with Visceral Leishmaniasis treated at a reference healthcare center in Fortaleza – Ceará, Brazil, from July 2010 to December 2013. Data from HIV-coinfected patients have been abstracted and compared to non-HIV controls diagnosed with Visceral Leishmaniasis in the same period.  Results:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmaniasis; HIV; Coinfection.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200092

Isolation of blaNDM-producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Barberino,Maria Goreth; Cruvinel,Silvia de Araujo; Faria,Célio; Salvino,Marco Aurélio; Silva,Marcio de Oliveira.
ABSTRACT Carbapenemases have great importance in the global epidemiological scenario since infections with carbapenemase-producing bacteria are associated with high mortality, especially in hospitalized patients in intensive care units. This study describes two microorganisms producers of the New Delhi Metallo-b-lactamase, Klebsiella pneumoniae and Citrobacter freundii, from two patients admitted to a public hospital in Salvador, Bahia. These are the first clinical cases of New Delhi Metallo-b-lactamase described in microorganisms in the north and northeast Brazil. The isolates were characterized by antimicrobial susceptibility test, with resistance to all β-lactams including carbapenems, negative Modified Hodge Test and the synergy test with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: New Delhi Metallo-b-lactamase; Carbapenemase; Antimicrobial resistance.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100047

Isolation of pathogenic yeasts in the air from hospital environments in the city of Fortaleza, northeast Brazil
Provedor de dados: 55
Autores: Cordeiro,Rossana A; Brilhante,Raimunda SN; Pantoja,Lydia DM; Moreira Filho,Renato E; Vieira,Patrícia RN; Rocha,Marcos FG; Monteiro,André J; Sidrim,José JC.
This paper reports the results of environmental surveillance of yeasts in specific areas of two tertiary local hospitals. From March 2007 to February 2008, samples from the air of two public hospitals were collected on a monthly basis. The samples were collected through passive sedimentation method (day and night exposure) of Petri dishes. A total of 240 air samples from 10 hospital environments were analyzed. These environments presented similar contamination levels, from which 80 fungi isolates were isolated: Candida parapsilosis (n = 34), Rhodotorula spp. (19), Trichosporon asahii (11), C. tropicalis (8), C. albicans (4), C. glabrata (1), C. guilliermondii (1), C. krusei (1) and Saccharomyces spp. (1). Regarding the presence of yeasts and climatic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Environmental monitoring; Air contamination; Yeasts; Hospitals.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100007

Isolation of Salmonella enterica serotype Worthington from a splenic abscess in a patient with chronic myeloid leukemia
Provedor de dados: 55
Autores: Ghadage,D.P.; Bal,A.M.
Splenic abscesses are caused by Staphylococcus aureus, Streptococcus and bacteria belonging to the family Enterobacteriaceae. We report a case of splenic abscess caused by an unusual serotype of Salmonella. A 55 year old man was admitted with complaints of fever and abdominal pain. On the basis of clinical findings and laboratory reports, a diagnosis of chronic myeloid leukemia was made. Ultrasonography of the abdomen revealed a single large cystic lesion in the spleen. Percutaneous drainage of the abscess was carried out. Salmonella enterica serotype Worthington was isolated from a pus sample taken from the abscess. The isolate was resistant to ampicillin, gentamicin, cefotaxime, chloramphenicol and tetracycline, and sensitive to amikacin and norfloxacin....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic myeloid leukemia; Splenic abscess; Worthington.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200005

Isolation, pathogenicity and disinfection of Staphylococcus aureus carried by insects in two public hospitals of Vitória da Conquista, Bahia, Brazil
Provedor de dados: 55
Autores: Oliveira,Pollianna S.; Souza,Simone G.; Campos,Guilherme B.; Silva,Danilo C.C. da; Sousa,Daniel S.; Araújo,Suerda P.F.; Ferreira,Laiziane P.; Santos,Verena M.; Amorim,Aline T.; Santos,Angelita M.O.G.; Timenetsky,Jorge; Cruz,Mariluze P.; Yatsuda,Regiane; Marques,Lucas M.
Currently, hospital infection is a serious public health problem, and several factors may influence the occurrence of these infections, including the presence of insects, which are carriers of multidrug-resistant bacterial species. The aim of this study was to isolate staphylococci carried by insects in two public hospitals of Vitoria da Conquista, Bahia and to identify the resistance profile, pathogenicity and efficacy of disinfection of the premises. A total of 91 insects were collected in 21 strategic points of these hospitals, and 32 isolated strains ofStaphylococcus aureus were isolated. Based on antibiogram and Minimum Inhibitory Concentration results, 95% of these strains were susceptible to oxacillin. These strains were also evaluated for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Insects; Staphylococcus aureus; Resistance; Virulence factors; Disinfection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200129

Isoniazid and rifampin drug susceptibility testing: application of 2,3,5-triphenyl tetrazolium chloride assay and microscopic-observation drug-susceptibility assay directly on Ziehl-Neelsen smear positive sputum specimens
Provedor de dados: 55
Autores: Shinu,Pottathil; Singh,Varsha; Nair,Anroop.
Abstract The current study was aimed to evaluate the performance of direct 2,3,5-triphenyl tetrazolium chloride assay and direct microscopic observation drug susceptibility assay with indirect Löwenstein-Jensen proportion method directly on Ziehl-Neelsen smear positive sputum specimens.  Methods Direct acid fast bacilli smear positive sputum specimens (n = 264) were subjected to isoniazid and rifampicin drug susceptibility testing by direct 2,3,5-triphenyl tetrazolium chloride assay, direct microscopic observation drug susceptibility assay, and the performances were compared with indirect Löwenstein-Jensen proportion method.  Results The direct 2,3,5-triphenyl tetrazolium chloride assay demonstrated an overall sensitivity, specificity, positive predictive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Rapid; Evaluation; Löwenstein–Jensen.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100033

Japanese encephalitis: a review of the Indian perspective
Provedor de dados: 55
Autores: Tiwari,Sarika; Singh,Rishi Kumar; Tiwari,Ruchi; Dhole,Tapan N.
Japanese encephalitis virus (JEV) causes Japanese encephalitis, which is a leading form of viral encephalitis in Asia, with around 50,000 cases and 10,000 deaths per year in children below 15 years of age. The JEV has shown a tendency to extend to other geographic regions. Case fatality averages 30% and a high percentage of the survivors are left with permanent neuropsychiatric sequelae. Currently, there is no cure for JEV, and treatment is mainly supportive. Patients are not infectious, but should avoid further mosquito bites. A number of antiviral agents have been investigated; however, none of these have convincingly been shown to improve the outcome of JEV. In this review, the current knowledge of the epidemiology and the pathogenesis of this deadly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Pathogenesis; Vector born diseases; Epidemics.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600011

JC virus: more than 40 years later with new implications
Provedor de dados: 55
Autores: Silva,Mônica Gomes da.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200001

JC virus-associated central nervous system diseases in HIV-infected patients in Brazil: clinical presentations, associated factors with mortality and outcome
Provedor de dados: 55
Autores: Piza,Felipe; Fink,Maria Cristina; Nogueira,Gilberto S.; Pannuti,Claudio S.; Oliveira,Augusto C. Penalva de; Vidal,José Ernesto.
INTRODUCTION: Several presentations of neurologic complications caused by JC virus (JCV) in human immunodeficiency virus (HIV)-infected patients have been described and need to be distinguished from the "classic" form of progressive multifocal leukoencephalopathy (PMl). The objectives of this study were: 1) to describe the spectrum and frequency of presentations of JCV-associated central nervous system (CNS) diseases; 2) identify factors associated with in-hospital mortality of patients with JCV-associated CNS disease; and 3) to estimate the overall mortality of this population. MATERIAL AND METHODS: This was a retrospective study of HIV-infected patients admitted consecutively for JCVassociated CNS diseases in a referral teaching center in São Paulo,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: JC virus leukoencephalopathy; Progressive multifocal Diagnosis Acquired immunodeficiency syndrome Brazil.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200008

JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region
Provedor de dados: 55
Autores: Cayres-Vallinoto,Izaura Maria Vieira; Vallinoto,Antonio Carlos Rosário; Pena,Giselle Priscila dos Anjos; Azevedo,Vânia Nakauth; Machado,Luiz Fernando Almeida; Ishak,Marluísa de Oliveira Guimarães; Ishak,Ricardo.
Abstract JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease. Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215 bp) and IG (610 bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: JCV; HIV-1; Co-infection; Brazilian Amazon region.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400360

José Borges Sales (1911-2006)
Provedor de dados: 55
Autores: Sousa,Anastácio de Queiroz; Menezes,Dalgimar Beserra de.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100041

Juvenile paracoccidioidomycosis in urban area: report of two cases
Provedor de dados: 55
Autores: Carneiro,Rodrigo da Costa; Miranda,Bianca Grassi de; Camilo Neto,Carlos; Tsukumo,Marina K; Fonseca,Cibele LC; Mendonça,João Silva de.
We present two cases of juvenile form of paracoccidioidomycosis (PCM), a systemic mycosis frequently found in rural areas, whose prognosis is poor in children and young adults. They are a 14-year-old boy and a 25-year-old woman, both residents in an urban area in São Paulo - Brazil, without any history of travelling to an endemic area. They have been admitted to the hospital due to fever, weight loss and lymphadenopathy. The diagnosis was confirmed by serologic and histopathologic study. Patients have recovered after therapy with oral itraconazole and were discharged from hospital, maintaining outpatient visits. In this article, the authors discuss the unusual presentation of PCM in an urban area.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Juvenile paracoccidioidomycosis; Lymphadenopathy; Paracoccidioides brasiliensis; Urban area.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100015

Kaposi's sarcoma simulating verrucous syndrome
Provedor de dados: 55
Autores: Ferreira,Cassio Porto; Miranda,Alice; Nery,José Augusto da Costa.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400444

Kidney involvement in leishmaniasis — a review
Provedor de dados: 55
Autores: Silva Junior,Geraldo Bezerra da; Barros,Elvino José Guardão; Daher,Elizabeth De Francesco.
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania transmitted by insects of the genus Lutzomyia sp. or Phlebotomus sp. The main syndromes are cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis (kala-azar) and post-kala-azar dermal leishmaniasis. This article reviews kidney involvement in cutaneous and visceral leishmaniasis, highlighting the aspects of their pathophysiology, clinical manifestations, histopathological findings, outcome and treatment.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; American cutaneous leishmaniasis; Kala-azar; Kidney disease.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400434

Kikuchi-Fujimoto disease: an unusual association with acute renal failure
Provedor de dados: 55
Autores: Silva,Amanda Feliciano da; Focaccia,Roberto; Oliveira,Allan Constantino de; Sementilli,Angelo; Reis,Gelvana Flávio Barreto.
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis of unknown etiopathogenesis, is a self-limited disease which frequently appears as feverish lymphadenomegaly, thus creating the need for differential diagnosis with lymphoma, systemic lupus erythematosus (SLE), infectious mononucleosis, cat-scratch disease, and toxoplasmosis with lymphonodal impairment. However, there are cases in which it may evolve with complications such as aseptic meningitis, cerebellar ataxia, and aseptic myocarditis. We are presenting a case of a 24-year-old man who had an initial picture of arthralgia, evening fever and adenomegaly. Kikuchi disease was diagnosed through lymph node biopsy with immunohistochemistry and evolves with severe systemic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kikuchi-Fujimoto disease; Histiocytic necrotizing lymphadenitis; Acute renal failure.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600012

Klebsiella ESBL bacteremia-mortality and risk factors
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Kruger,Margot; Terreri,Marcos; Penteado-Filho,Sergio R; Gortz,Lucas.
Background: Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital. Methods: A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility. Results: Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Klebsiella pneumoniae; Beta-lactamases; Bacteremia; Carbapenems.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600016

Klebsiella pneumoniae outbreak in a cancer unit of a general hospital: predisposing factors and evaluation of the impact of intervention measures
Provedor de dados: 55
Autores: Silva,Cristiane Pavanello Rodrigues; Amarante,Jorge Manoel Buchdid; Lacerda,Rúbia Aparecida; Biancalana,Maria Lúcia das Neves.
We made a retrospective cohort study of a primary bloodstream infection outbreak in patients of a cancer unit in a general hospital, evaluated the impact of intervention measures and investigated the predisposing factors. The targeted predisposing factors were selected based on the medical literature. The data were treated with univariate analysis to calculate the relative risk, and statistical significance was set at p&lt;0.05. The presence of a long-term totally-implanted central venous catheter appears to be a predisposing factor, while a peripheral venous catheter appears to have offered protection from infection. This is reinforced by fact that intervention measures controlled the outbreak, suggesting cross-contamination from a common source. These...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infection; Hospital-acquired infection.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300005

Klebsiella pneumoniae with multiple antimicrobial resistance
Provedor de dados: 55
Autores: Mendes,Caio; Kiffer,Carlos; Segura,Adília; Ribeiro,Julival; Turner,Philip.
A Klebsiella pneumoniae strain was isolated from the urine of a patient at one of the centers participating in the 2001 edition of the MYSTIC program in Brazil. The initial phenotypic findings of the isolated K. pneumoniae presented an unusual MIC of 8 mug/mL to meropenem, 2 mug/mL to imipenem, elevated MICs to broad spectrum cephalosporins (ceftazidime/cefotaxime/cefepime MIC &gt; 256 mug/mL), aminoglycosides (gentamycin &gt; 256 mug/mL and tobramycin = 48 mug/mL), piperacillin/tazobactam (MIC &gt; 256 mug/mL) and susceptibility to ciprofloxacin (MIC = 0.25 mug/mL). The strain also tested positive for ESBL production with double-disk and E-test methodologies. More detailed investigation revealed that the strain produced a SHV-4 type enzyme and also lacked...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Klebsiella pneumoniae; Drug effects; Drug resistance; Carbapenems.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100008

Knowledge about viral hepatitis among participants of Gay Pride Event in Brazil
Provedor de dados: 55
Autores: Delvaux,Nathália; Paula,Vanessa S. de; Espírito-Santo,Márcia P. do; Silva,Elisangela F. da; Miguel,Juliana C.; Oliveira,Jaqueline C. de; Silva,Alexandre S. da; Vieira,Yasmine R.; Lampe,Elisabeth; Villar,Livia M.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300012

Knowledge, attitudes and practices on HIV/AIDS and prevalence of HIV in the general population of Sucre, Bolivia
Provedor de dados: 55
Autores: Terán Calderón,Carolina; Gorena Urizar,Dorian; González Blázquez,Cristina; Alejos Ferreras,Belén; Rubio,Oriana Ramírez; Bolumar Montrull,Francisco; Ortiz Rivera,Marta; del Amo Valero,Julia.
Background: To analyse knowledge, attitudes and sexual practices on HIV/AIDS, and estimate HIV prevalence among residents of Sucre (Bolivia).Methodology: Population-based survey of residents aged 15-49 randomly selected during 2008/2009. Blood samples were collected on Whatman-ﬁlter paper and tested with enzyme-linked immunosorbent assay. Knowledge on HIV/AIDS, sexual risk practices and discriminatory attitudes against people living with HIV/AIDS (PLWHA) were modelled with multiple logistic regression.Results: Of 1499 subjects, 59% were women. All subjects were HIV-negative. Inadequate knowledge of HIV/AIDS transmission and prevention was observed in 67% and risk factors varied by gender (interaction p-value &lt; 0.05). Discriminatory attitudes were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV prevalence; Knowledge on HIV/AIDS; Attitude towards PLWHA; Sexual practices on HIV.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400369

Knowledge of the patients regarding leprosy and adherence to treatment
Provedor de dados: 55
Autores: Lira,Karlisson Bezerra; Leite,João Jaime Giffoni; Maia,Débora Castelo Branco de Souza Collares; Freitas,Rafael de Mesquita Ferreira; Feijão,Alexsandra Rodrigues.
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It is known for its great disfiguring capacity and is considered an extremely serious disease to public health worldwide. The state of Ceará ranks 13th in number of cases of leprosy in Brazil, and fourth in Northeastern region, with an average of 2,149 new cases diagnosed every year. This study aimed to evaluate the knowledge of leprosy patients regarding treatment, and to assess the level of treatment adherence and its possible barriers. The study was conducted in the reference center for dermatology, from September 2010 to October 2010, in Fortaleza, Ceará. The study data were collected by means of a structured interview, along with the Morisky-Green test, in order to assess...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leprosy; Adherence; Knowledge.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500012

KPC-producing Enterobacter aerogenes infection
Provedor de dados: 55
Autores: Tuon,Felipe F.; Scharf,Camila; Rocha,Jaime L.; Cieslinsk,Juliette; Becker,Guilherme Nardi; Arend,Lavinia N.
Background: Enterobacteris a common nosocomial microorganism and its carbapenem's resistance has increased. The management of these cases is unclear.Objective: We evaluated 16 patients with KPC-producing Enterobacter aerogenesinfections, detailing the site of infection, therapy, clinical and epidemiological data.Methods: A retrospective and descriptive study. Clinical data were revised and KPC-2 detection was by molecular methods. Risk factors associated with mortality were compared using appropriate tests according to variable type with a significance level of 0.05.Results: The 30-day mortality rate was 37.5% with no association with inadequate treatment. Age (p= 0.004) and Charlson score of comorbidities (p= 0.048) were independent risk factors...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: KPC Enterobacter; Carbapenemase; Infection control.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300324

Labial ulcer: oral manifestation of syphilis
Provedor de dados: 55
Autores: Vera-Kellet,Cristian; Harz-Fresno,Isidora; Manriquez,Juan.
Tipo: Info:eu-repo/semantics/report
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500570

Laboratorial diagnosis of lymphocytic meningitis
Provedor de dados: 55
Autores: Almeida,Sérgio Monteiro de; Nogueira,Meri Bordignon; Raboni,Sonia Mara; Vidal,Luine Rosele.
Meningitis is the main infectious central nervous system (CNS) syndrome. Viruses or bacteria can cause acute meningitis of infectious etiology. The term "Aseptic Meningitis" denotes a clinical syndrome with a predominance of lymphocytes in the cerebrospinal fluid (CSF), with no common bacterial agents identified in the CSF. Viral meningitis is considered the main cause of lymphocyte meningitis. There are other etiologies of an infectious nature. CSF examination is essential to establish the diagnosis and to identify the etiological agent of lymphocytic meningitis. We examined CSF characteristics and the differential diagnosis of the main types of meningitis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cerebrospinal fluid; Lymphocytic meningitis; Viral meningitis; Meningitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500010

Laboratory testing for hepatitis C
Provedor de dados: 55
Autores: Gonçales,Neiva Sellan Lopes; Gonçales Junior,Fernando Lopes.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700008

Laboratory tests in the detection of extended spectrum beta-lactamase production: National Committee for Clinical Laboratory Standards (NCCLS) screening test, the E-test, the double disk confirmatory test, and cefoxitin susceptibility testing
Provedor de dados: 55
Autores: d'Azevedo,Pedro A.; Gonçalves,Ana Lúcia S.; Musskopf,Maiara I.; Ramos,Carina G.; Dias,Cícero A. G.
Extended spectrum beta-lactamase (ESBL) production by Klebsiella sp. and E. coli is an emerging problem. In this study, 107 clinical isolates (53 E. coli, 47 K. pneumoniae and 7 K. oxytoca) screened as ESBL producers by the NCCLS disk diffusion procedure were submitted to a double disk confirmatory test (DDT) and to the E-test double strip for confirmation of ESBL production by demonstration of clavulanic acid inhibition effect (CAIE). Only 72/107 (67%) of the isolates were confirmed as ESBL producers by DDT, with diverse results among species. By the E-test, 58/107 (54%) isolates were confirmed as ESBL producers, and 18/107 (17%) were not determinable. Susceptibility to cefoxitin was found in 57/68 (83%) of strains that did not show CAIE. ESBL detection...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL; Double disk confirmatory test; Cefoxitin susceptibility testing; Screening test.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500006

Lack of effect of motivation on the adherence of HIV-positive/AIDS patients to antiretroviral treatment
Provedor de dados: 55
Autores: Garcia,Rosa; Pondé,Milena; Lima,Manuela; Souza,Alba Regina de; Stolze,Silvia Maria de O.; Badaró,Roberto.
As a result of the potent drug combinations of reverse transcriptase inhibitors and protease inhibitors currently available, it is now possible to achieve extreme reductions in the numbers of viral particles in the peripheral blood of HIV-positive patients undergoing treatment, to the point that they are undetectable. Moreover, the immunological recovery resulting from continued and prolonged use of these drugs significantly reduces both mortality and the incidence of opportunistic infections. However, the strict therapeutic regimens required, the number of pills, adverse events and the stigma of a disease that requires the patient to introduce pill-taking into his/her lifestyle brings into question one aspect of mental health, which is motivation to do...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Motivation; Adherence; HIV-Positive/AIDS; Treatment.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600007

Lagochilascariasis in a housecat and the potential risk for human disease
Provedor de dados: 55
Autores: Sudré,Adriana Pittella; Uchôa,Flávia; Brener,Beatriz.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100024

Lamivudine for chronic hepatitis B: a brief review
Provedor de dados: 55
Autores: Palumbo,Emilio.
Until recently, the only generally approved treatment for chronic hepatitis B was alpha-interferon; however, it gives only moderate efficacy in terms of sustained response (biochemical, virological and histological). In fact, only 20% to 40% of treated patients respond to therapy, with lower percentages (~ 10%) among patients infected with precore-mutant strains of HBV (HBeAb HBV-DNA positive). The FDA of the USA approved the use of lamivudine in adult patients affected by chronic hepatitis B in 1998. In this review, we focused on the pharmacokinetic and pharmacodynamic properties and efficacy and tolerability of lamivudine in the treatment of chronic hepatitis B cases that are both HBeAg and anti-HBe-positive.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lamivudine; Hepatitis; HBV.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500002

Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit
Provedor de dados: 55
Autores: Resende,Daiane Silva; Peppe,Anna Laura Gil; Reis,Heloisio dos; Abdallah,Vânia Olivetti Steffen; Ribas,Rosineide Marques; Gontijo Filho,Paulo Pinto.
Aim:We assessed late onset sepsis (LOS) rates of neonates in a neonatal intensive care unit (NICU) before and after implementing an evidence-based bundle to prevent these infections in a country with poor resources.Methods:We evaluate trends of LOS between October 2010 and August 2012 in a large tertiary hospital in Brazil. We designed a protocol based of CDC guidelines for insertion of maintenance of central venous catheter targeted to reduction of bloodstream infections. During this period two major events occurred: a great increase of LOS rates in January months and relocation of the unit to a provisory place. Additionally we evaluated the risk factors and etiology of these infections.Results:A total of 112 (20.3%) cases deﬁned as LOS were found. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Late onset sepsis; Bundle; Neonates.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100052

Latent human herpesvirus - 8 (HHV-8) infection in female commercial sex workers from Imbituba, Santa Catarina, Brazil
Provedor de dados: 55
Autores: Caterino-de-Araujo,Adele; Santos-Fortuna,Elizabeth; Magri,Mariana Cavalheiro; Schuelter-Trevisol,Fabiana; Silva,Marcos Vinicius.
Human herpesvirus 8 (HHV-8) infection was identified in 6 out of 90 (6.7%) female commercial sex workers from Imbituba, Santa Catarina, and was associated to age. Frequencies of 5.6% of anti-latent and 3.3% of anti-lytic antibodies were detected. Considering non-endemic areas from Brazil, the anti-latent antibodies frequency seems elevated and requires further investigation on referent female population.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HHV-8; Serology; Anti-latent antibodies; Female sex workers.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100004

Leishmania donovani infection activates Toll-like receptor 2, 4 expressions and Transforming growth factor-beta mediated apoptosis in renal tissues
Provedor de dados: 55
Autores: Kumar,Vinod; Tiwari,Neeraj; Gedda,Mallikarjuna Rao; Haque,Rizwanul; Singh,Rakesh K.
Abstract The present study was aimed to identify the underlying mechanisms of improper renal function in Leishmania donovani infection that causes VL. Mice (BALB/c) were infected with L. donovani and different parameters for proteinuria were assessed. The levels of superoxide anion (O2 -), hydrogen peroxide (H2O2), lipid peroxidation (MDA), inflammatory cytokines, and toll-like receptor (TLR) 2 and 4 expression were found significantly elevated at 60th day in these animals and declined at 90th day post infection. However, TGF-β and caspase 3 activities were higher at 90th day in comparison to 60th day post infection. These findings suggested that exacerbated inflammatory conditions correlate with abnormal renal functions in L. donovani infection, which is...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leishmaniasis; Renal; TLRs; Apoptosis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500545

Leishmania mexicana infection of the eyelid in a traveler to Belize
Provedor de dados: 55
Autores: Vinetz,Joseph M.; Soong,Lynn.
A 50 year-old man, a United States resident, presented in Texas with a violaceous non-ulcerating lesion, involving the entire lower eyelid. The patient had traveled to a jungle area of Belize several hours drive from the capital city. Leishmania mexicana was isolated. The lesion only partially resolved after an initial course of sodium stibogluconate, requiring retreatment. At two years of follow-up, there was no relapse. The parasite isolated from the patient caused a progressive, non-ulcerating lesion in an experimental mouse footpad infection. This is an unusual case of cutaneous leishmaniasis in a traveler. Travelers must be educated about personal protective measures to prevent exotic infections acquired during travel.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Leishmania mexicana; Traveler; Belize.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100030

Leishmania mexicana infection of the eyelid in a traveler to Belize
Provedor de dados: 55
Autores: Vinetz,Joseph M.; Soong,Lynn.
A 50 year-old man, a United States resident, presented in Texas with a violaceous non-ulcerating lesion, involving the entire lower eyelid. The patient had traveled to a jungle area of Belize several hours drive from the capital city. Leishmania mexicana was isolated. The lesion only partially resolved after an initial course of sodium stibogluconate, requiring retreatment. At two years of follow-up, there was no relapse. The parasite isolated from the patient caused a progressive, non-ulcerating lesion in an experimental mouse footpad infection. This is an unusual case of cutaneous leishmaniasis in a traveler. Travelers must be educated about personal protective measures to prevent exotic infections acquired during travel.
Tipo: Info:eu-repo/semantics/review
Palavras-chave: Leishmania mexicana; Traveler; Belize.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400016

Lemierre syndrome from a neck abscess due to methicillin-resistant Staphylococcus aureus
Provedor de dados: 55
Autores: Abhishek,Agarwal; Sandeep,Singla; Tarun,Pandey.
Lemierre syndrome is characterized by acute septic thrombophlebitis of the internal jugular vein (IJV) that develops after an oropharyngeal infection, and can be complicated by septic emboli to lungs and other organs. The most frequent causative agent is Fusobacterium necrophorum, an anaerobic bacillus found in normal oropharyngeal flora. Staphylococcus aureus has emerged as a cause of Lemierre syndrome in the last decade. We report a case of a 24-year-old man who developed septic IJV thrombosis and necrotizing pneumonia due to S. aureus from an infected hematoma in the right sternocleidomastoid muscle. Antibiotics are the mainstay of therapy with few cases needing anticoagulation. A good outcome is dependent upon an awareness of the condition, a high...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Internal jugular vein thrombosis; Staphylococcus aureus; Pulmonary emboli; Septic emboli.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400024

Length of exposure to the hospital environment is more important than antibiotic exposure in healthcare associated infections by methicillin-resistant Staphylococcus aureus: a comparative study
Provedor de dados: 55
Autores: Baraboutis,Ioannis G; Tsagalou,Eleftheria P; Papakonstantinou,Ilias; Marangos,Markos N; Gogos,Charalambos; Skoutelis,Athanasios T; Bassaris,Haralambos; Johnson,Stuart.
OBJECTIVES: Both total antimicrobial use and specific antimicrobials have been implicated as risk factors for healthcare-associated methicillin-resistant Staphylococcus aureus (HCA-MRSA) infection. The aims of this study were: (I) to explore predictors of a new HCA-MRSA infection in comparison with a new healthcare-associated methicillin-sensitive Staphylococcus aureus (HCA-MSSA); (II) to thoroughly assess the role of recent antibiotic use qualitatively and quantitatively. METHODS: The time-period for our study was from October 1997 through September 2001. Through applying strict criteria, we identified two groups of inpatients, one with a new HCA-MRSA infection and one with a new HCA-MSSA infection. We recorded demographic, clinical and antibiotic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; Antibacterial agents; Fluoroquinolones.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500003

Leprosy and hepatitis B coinfection in southern Brazil
Provedor de dados: 55
Autores: Leitão,Cleverson; Ueda,Denis; de Moraes Braga,Anna Carolina; Boldt,Angelica B.W.; Messias-Reason,Iara J.T.
To investigate the association of leprosy with hepatitis B virus (HBV) infection, as yet unknown for South Brazil, we assessed hepatitis B virus coinfection in 199 South Brazilian leprosy patients (119 lepromatous, 15 tuberculoid, 30 borderline, 12 undetermined and 23 unspecified) and in 681 matched blood donors by screening for the hepatitis B virus markers HBSAg and anti-HBc, using ELISA. Positive samples were retested and anti-HBc+ only samples were tested for the hepatitis B surface antibody (anti-HBs). There was a strong association between leprosy and hepatitis B virus infection (OR = 9.8, 95% CI = 6.4–14.7; p = 0.004·E−30), as well as an association between HBV infection and lepromatous leprosy, compared to other forms (OR = 2.4, 95% CI = 1.2–4.8; p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leprosy; Hepatitis B; Leprosarium; HBV; Mycobacterium leprae.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100008

Leprosy with necrosis in granulomatous reaction
Provedor de dados: 55
Autores: Trindade,Maria Ângela Bianconcini; Brandt,H.; Teixeira,R.; Sotto,M.N.; Fleury,R.N.
Tipo: Info:eu-repo/semantics/report
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500022

Leptospirosis as a cause of acute respiratory failure: clinical features and outcome in 35 critical care patients
Provedor de dados: 55
Autores: Vieira,Silvia R R; Brauner,Janete S.
Leptospirosis may have important complications, such as acute respiratory failure (ARF) associated or not with other organic dysfunction, with a high mortality rate. We report the characteristics and evolution of severe leptospirosis associated with ARF. During 10 years, 35 consecutive adult patients admitted in two general Intensive Care Units with severe leptospirosis and ARF, were followed up. Clinical characteristics, associated organic dysfunction and mortality were analyzed. Survivors were compared with non-survivors. The most frequent clinical manifestations were dyspnea, fever, myalgia, jaundice, hemoptysis and coughing. All patients presented ARF, needing mechanical ventilation, as well as other organic dysfunctions. The mortality rate was 51%....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Acute respiratory failure.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300006

Leptospirosis in elderly patients
Provedor de dados: 55
Autores: Gancheva,Galya Ivanova.
Leptospirosis is a re-emerging zoonosis with broad clinical spectrum and high mortality in severe forms. The aim of this study was to analyze clinical manifestations, laboratory findings, epidemiological data, and management in elderly patients with leptospirosis. Toward that end, we performed a descriptive analysis of 15 leptospirosis elderly cases (age 60-78 years) treated at the Clinic of Infectious Diseases of University Hospital - Pleven (1976-2012). Patients were serologically confirmed by microscopic agglutination test. Twelve cases (80%) presented with the severe form of leptospirosis. Co-morbidity (hypertonic diseases, chronic pulmonary diseases, chronic alcohol abuse, and diabetes) was registered in 13 cases. All cases had fever, oliguria,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Acute renal failure; Age; Leptospirosis; Outcome.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500012

Leptospirosis in India and the rest of the world
Provedor de dados: 55
Autores: Rao,R. Sambasiva; Gupta,Naveen; Bhalla,P.; Agarwal,S.K.
Leptospirosis is an acute anthropo-zoonotic infection of worldwide significance caused by spirochaete Leptospira interrogans which has 23 serogroups and &gt;200 serovars. Various factors influencing the animal activity, suitability of the environment for the survival of the organism and behavorial and occupational habits of human beings can be the determinants of incidence and prevalence of the disease. The disease was considered inconsequential till recently, but it is emerging as an important public health problem during the last decade or so due to sudden upsurge in the number of reported cases and outbreaks. Since isolation rate of the microorganism from clinical specimens is low due to prior indiscriminate use of antibiotics, serological techniques...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: India; Leptospirosis; World.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300003

Leptospirosis mimicking sepsis after orthopedic surgery: a case report
Provedor de dados: 55
Autores: Abboud,C. S.; Vargas,J; Ferraretto,I.
We report a case of leptospirosis that occurred after elective surgery involving tendon transfer and shoulder arthroscopy. The disease mimicked hospital infection after orthopedic surgery and was at first misdiagnosed as post-operative sepsis. The patient was 60 year old female that developed sepsis with hypotension, shock, bleeding, jaundice and renal insufficiency 4 hours after surgery. Shock treatment procedures were performed and broad spectrum antibiotic therapy was used with coverage for bacteria acquired in hospitals. A careful investigation was carried out by the Hospital Infection Control Service in search of the possible source of the infection. After clinical evaluation by a specialist in infectious diseases, the hypothesis of leptospirosis was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Sepsis; Orthopedic surgery.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500006

Leptospirosis presenting as ascending progressive leg weakness and complicating with acute pancreatitis
Provedor de dados: 55
Autores: Silva,Andre Pacheco; Burg,Luciana Bonnassis; Locatelli,João Felipe Schadeck; Manes,Joice; Crispim,Morgana.
Leptospirosis is a spirochetal bacterial infection of great public health importance. It has a broad spectrum of clinical manifestations which goes from subclinical infection and self-limited anicteric febrile illness (80-90% of all cases) to icteric leptospiropirosis known as Weil's disease. This is a severe disease characterized by hemorrhage, acute renal failure and jaundice. It is uncommon for leptospirosis to present itself as a primary neurological disease. Additionally, acute pancreatitis is an unusual gastrointestinal manifestation. We report a case of leptospirosis presenting as ascending progressive leg weakness and complicating with acute pancreatitis in an adult patient treated at Hospital Universitário, Universidade Federal de Santa Catarina....
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Leptospirosis; Pancreatitis; Neurologic manifestations.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500016

Lessons to learn with the methicillin-resistant Staphylococcus aureus control in Norway
Provedor de dados: 55
Autores: Cruz,Elaine Drehmer de Almeida; Pimenta,Fabiana Cristina; Andersen,Bjorg Marit; Gir,Elucir.
The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Norway is low, compared to other European and American countries. The health system includes mandatory case reporting and has written guidelines for prevention and control. This communication describes the national public policies related to MRSA obtained from documents and academic experience gained during a doctoral fellowship in Oslo, Norway. The painstaking procedures used for investigating suspected cases, including health professionals, decolonization and case monitoring, could be important tools to be used by countries with a high prevalence of MRSA.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Staphylococcus aureus; Resistance to methicillin; Hospital infection epidemiological surveillance.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600015

Light emitting diode fluorescence microscopy versus Ziehl–Neelsen smear microscopy for the diagnosis of pulmonary tuberculosis
Provedor de dados: 55
Autores: Upadhyaya,Shambhu Kumar; Pant,Narayan Dutt; Bhandari,Raju; Poudel,Asia; Shrestha,Bhawana.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500522

Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil
Provedor de dados: 55
Autores: Bessa,Márcia; Rodart,Itatiana Ferreira; Menezes,Gisele Barreto Lopes; Carmo,Theomira Mauadi de Azevedo; Athanazio,Daniel A.; Reis,Mitermayer G.
HCV infected patients frequently ask their physician about the risk of transmission to their partners. Although it is easy to answer that the risk does exist, it is difficult to quantify. We studied the transmission of HCV infection in stable heterosexual couples: anti-HCV positive patients in hemodialytic therapy and their partners. Thirty-four couples were tested by third generation ELISA and RIBA. Blood samples of anti-HCV positive patients were evaluated by RT-PCR and detected sequences were genotyped by restriction fragment length polymorphism. Concordance of infection was observed in only one couple in which both subjects were in dialytic therapy. One other partner had two positive ELISA tests and an indeterminate RIBA, with negative RT-PCR, which...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Renal dialysis; Sexual partners; Sexually transmitted diseases.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400004

Linezolid-induced angioedema and urticaria in a patient with renal failure
Provedor de dados: 55
Autores: Yang,Meifang; Xu,Min.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600023

Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
Provedor de dados: 55
Autores: Guimarães,Milena Maria Moreira; Greco,Dirceu Bartolomeu; Moreira,Allyson Nogueira; Guimarães,Nathalia Sernizon; Freire,Cláudia Maria Vilas; Rohlfs,Bruna Guimarães; Machado,Lucas José de Campos.
ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p &lt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hyperlipidemia; Atherosclerosis; Lipid accumulation product index; Cardiovascular risk; Insulin resistance.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171

Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: correlation with CD4+ lymphocytes
Provedor de dados: 55
Autores: Treitinger,Arício; Spada,Celso; Silva,Laura Maria D. da; Hermes,Elizabeth Martins; Amaral,Jorge Antônio; Abdalla,Dulcineia Saes Parra.
Lipid and acute-phase protein alterations have been described in various infection diseases, and they have been recorded during the early stages of HIV infection. Lipid and acute-phase protein profiles also have been correlated with cellular immunological abnormalities. To document these correlations during HIV infection, we studied 75 HIV-infected patients and 26 HIV-negative controls. Patients were classified according to the criteria proposed by the Walter Reed Army Institute: as WR-1 (CD4 lymphocytes, 1154 ± 268/mm³), WR-2 (CD4, 793 ± 348/mm³) and WR3/4 (CD4, 287±75 mm³). Triglycerides, total cholesterol and HDL-cholesterol concentrations were measured by enzymatic methods. Immunoglobulins (IgA and IgG) and acute-phase proteins (haptoglobin, a1-acid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; CD4+; Triglycerides; IgA; A1-acid glycoprotein; Haptoglobin.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400005

Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
Provedor de dados: 55
Autores: Alves,Crésio; Oliveira,Ana Cláudia; Brites,Carlos.
The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohipertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohipertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Highly active antiretroviral treatment; Children and adolescents.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400018

Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review
Provedor de dados: 55
Autores: Pellicelli,Adriano M; D'Ambrosio,Cecilia; Villani,Roberto; Cerasari,Giuseppe; Ialongo,Pasquale; Cortese,Andrea; Grillo,Lucia Rosalba; Soccorsi,Fabrizio.
Only few cases of rhino-orbital mucormycosis in patients with liver cirrhosis are described in the literature and most of these patients showed an associated diabetes mellitus. We describe a case of rhino-orbital mucormycosis in a patient with liver cirrhosis without other risk factors.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Liver cirrhosis; Rhino-orbital mucormycosis; Immunocompromised patients; Mucor; Surgical treatment.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400015

Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
Provedor de dados: 55
Autores: Santana,Nelma Pereira de; Freitas,Luiz A.R. de; Lyra,André Castro; Paraná,Raymundo; Santana,Genoile; Trepo,Christian; Lyra,Luiz G.C.
Patients with chronic hepatitis C can have variable clinical progression. Hepatic histological alterations appear to be milder in asymptomatic subjects who have persistently normal ALT levels. AIMS: To evaluate the severity of histological liver alterations in blood donors with normal and elevated ALT levels. METHODS: We evaluated volunteer blood donors from the main blood bank of the city of Salvador-Brazil. Those who were anti-HCV positive were invited to participate in the study. Serum ALT and AST levels were measured at two time points, two months apart. Donors were divided into two groups: group I, individuals with ALT &gt; 1.5 times the upper limit of normal in at least one time point and group II, individuals with normal or near normal ALT, at both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ALT levels; Liver alterations; HCV; Northeast-Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200003

Local circulating clones of Staphylococcus aureus in Ecuador
Provedor de dados: 55
Autores: Zurita,Jeannete; Barba,Pedro; Ortega-Paredes,David; Mora,Marcelo; Rivadeneira,Sebastián.
ABSTRACT The spread of pandemic Staphylococcus aureus clones, mainly methicillin-resistant S. aureus (MRSA), must be kept under surveillance to assemble an accurate, local epidemiological analysis. In Ecuador, the prevalence of the USA300 Latin American variant clone (USA300-LV) is well known; however, there is little information about other circulating clones. The aim of this work was to identify the sequence types (ST) using a Multiple-Locus Variable number tandem repeat Analysis 14-locus genotyping approach. We analyzed 132 S. aureus strains that were recovered from 2005 to 2013 and isolated in several clinical settings in Quito, Ecuador. MRSA isolates composed 46.97% (62/132) of the study population. Within MRSA, 37 isolates were related to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; MSSA; Epidemic clones; MLVA typing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600525

Localized hepatic tuberculosis presenting as fever of unknown origin
Provedor de dados: 55
Autores: Ferrari,Teresa Cristina Abreu; Couto,Carolina Mundim; Vilaça,Tatiane Silva; Xavier,Marcelo Antônio Pascoal.
Localized hepatic tuberculosis is a rare clinical form of tuberculosis infection; it has signs and symptoms related only to hepatic injury, with minimal or no extrahepatic involvement. It frequently presents as a non-specific syndrome, with systemic manifestations, which can sometimes result in a diagnostic dilemma. A high index of suspicion is required and a definitive diagnosis can be very difficult. We report a case of localized hepatic tuberculosis that presented as fever of unknown origin.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; Fever of unknown origin; Granulomatous hepatitis.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500013

Long term effect of switching to darunavir/ritonavir in HIV infected patients previously on protease inhibitor therapy
Provedor de dados: 55
Autores: Ucciferri,Claudio; Falasca,Katia; Vignale,Francesca; Di Nicola,Marta; Vecchiet,Jacopo.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400401

Long term effect of telmisartan in HIV-positive male patients with high blood pressure
Provedor de dados: 55
Autores: Ucciferri,Claudio; Falasca,Katia; Vignale,Francesca; Nicola,Marta Di; Vecchiet,Jacopo.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600668

Long term neurologic sequelae in a Mexican rocky mountain spotted fever case
Provedor de dados: 55
Autores: Dzul-Rosado,Karla Rossanet; Lugo-Caballero,Cesar; Salcedo-Parra,Alejandra; López-Soto,Raymundo Daniel; Faccini-Martínez,Álvaro A.
ABSTRACT During the second half of the twentieth century, neurologic sequelae associated with central nervous system impairment caused by Rickettsia rickettsii were studied widely and exclusively in the United States. We present the case of a Mexican pediatric patient with neurologic sequelae 10 years after an acute infection by R. rickettsii.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Rocky mountain spotted fever; Rickettsia rickettsii; Neurologic manifestations.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200121

Long-term follow-up of patients with chronic hepatitis C with sustained virologic response to interferon
Provedor de dados: 55
Autores: Ferreira,Sandro da Costa; Carneiro,Marcos de Vasconcelos; Souza,Fernanda Fernandes; Teixeira,Andreza Corrêa; Villanova,Marcia Guimarães; Figueiredo,José Fernando de Castro; Passos,Afonso Dinis Costa; Ramalho,Leandra Naira Zambelli; Zucoloto,Sergio; Martinelli,Ana de Lourdes Candolo.
BACKGROUND AND AIM: The durability of the sustained virologic response (SVR) in patients with chronic hepatitis C after treatment and the ideal follow-up time for these patients remains undefined. The objective of the study was to evaluate the durability of the virologic response in patients with chronic hepatitis C followed up for at least 12 months after SVR at HCFMRP-USP. METHODS: The study was conducted on 174 patients with chronic hepatitis C treated with different antiviral regimens who had achieved SVR. Qualitative serum HCV-RNA was determined by the commercial kit (COBAS AMPLICOR HCV, v2.0). RESULTS: There was predominance of male (73%) with a mean age of 45.6 ± 10 years. Liver cirrhosis was present in 16.1% of the study subjects. Mean follow-up...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Interferon; HCV; Follow-up; Hepatocellular carcinoma.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400003

Long-term treatment of persistent disseminated Nocardia cyriacigeorgica infection
Provedor de dados: 55
Autores: Özgenç,Onur; Avcı,Meltem; Arı,Alpay; Çelebi,İsmail Yunus; Coşkuner,Seher Ayten.
In this paper a disseminated persistent Nocardia cyriacigeorgicainfection in an immunocompetent patient is described. The patient's long-term treatment, as well as its implications for managing similar cases in the future, is emphasized. Presenting with high fever, multiple nodules, and ulcerative cutaneous lesions of body sites, the patient was treated with various antimicrobials. Under combined therapy, empyema and arthritis, leading to disseminated nocardiosis, were seen. The overall treatment course was 28 months. It can be concluded that the choice of the antibiotics and optimal duration of treatment are uncertain; therefore the treatment of nocardiosis requires expertise.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nocardia cyriacigeorgica; Chronic infection; Treatment.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500556

Long-term trends in the epidemiology of human enteropathogens in Malaysia
Provedor de dados: 55
Autores: Shunmugam,Pavithrah; Kanapathy,Swarnaletchumi; Chan,Shiao-Ee; Singh,Kirnpal-Kaur Banga.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600021

Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients
Provedor de dados: 55
Autores: Zhu,Haohui; Yuan,Jianjun; Wang,Yisa; Gao,Fan; Wang,Xiao; Wei,Changhua; Chen,Jiyun; Fan,Xiaohui; Zhang,Mei.
Objective:To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China.Method:Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative artery stiffness, respectively.Results:No statistically significant difference in carotid artery intima-media thickness and stiffness was observed between groups. A...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Artery stiffness; AIDS; Ultrasound; HAART.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500496

Long-term virologic and immunologic responses on darunavir/ritonavir - containing regimens among highly antiretroviral therapy-experienced patients: 7-year follow-up of a prospective cohort study in São Paulo, Brazil
Provedor de dados: 55
Autores: Vidal,José E.; Santos,Ariane M.R. dos; Miranda,Érique J.F. Peixoto de; Segurado,Aluísio C.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600680

Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities
Provedor de dados: 55
Autores: Peixoto,Mario Ferreira; Pilotto,José Henrique; Stoszek,Sonia Karolina; Kreitchmann,Regis; Mussi-Pinhata,Marisa Márcia; Melo,Victor Hugo; João,Esaú Custodio; Ceriotto,Mariana; Souza,Ricardo da Silva de; Read,Jennifer.
OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r) dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009) enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day) (Group 1)] and 70 increased dosing [(&gt; 800/200 mg/day) (Group 2)]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts &gt; 500 cells/mm³. Mean plasma viral load was higher in Group 2. There were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnancy; HIV; HIV protease inhibitors; Drug toxicity.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300013

Low compliance with alcohol gel compared with chlorhexidine for hand hygiene in ICU patients: results of an alcohol gel implementation program
Provedor de dados: 55
Autores: Camargo,Luis Fernando Aranha; Marra,Alexandre Rodrigues; Silva,Cláudia Vallone; Laselva,Cláudia Regina; Moura Junior,Denis Faria; Cal,Ruy Guilherme G.; Yamashita,Maria Aparecida; Knobel,Elias.
Although the introduction of alcohol based products have increased compliance with hand hygiene in intensive care units (ICU), no comparative studies with other products in the same unit and in the same period have been conducted. We performed a two-month-observational prospective study comparing three units in an adult ICU, according to hand hygiene practices (chlorhexidine alone-unit A, both chlorhexidine and alcohol gel-unit B, and alcohol gel alone-unit C, respectively). Opportunities for hand hygiene were considered according to an institutional guideline. Patients were randomly allocated in the 3 units and data on hand hygiene compliance was collected without the knowledge of the health care staff. TISS score (used for measuring patient complexity)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alcohol gel and chlorhexidine; Hand washing; ICU.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500003

Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil
Provedor de dados: 55
Autores: Barreto,Raphael Gusmão; Brites,Carlos.
Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hypersensitivity; Antiretroviral; HIV; Abacavir.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400268

Low incidence of colonization and no cases of disseminated Mycobacterium avium complex infection (DMAC) in Brazilian AIDS patients in the HAART era
Provedor de dados: 55
Autores: Gadelha,Ângela; Accácio,Náurea; Grinzstejn,Beatriz; Veloso,Valdiléa; Silveira,Liane Braga da; Fandinho,Fátima; Saad,Maria Helena; Lourenço,Maria Cristina; Rolla,Valeria.
OBJECTIVE: Evaluate the incidence of mycobacterial disease and the colonization of the respiratory and gastrointestinal tracts by Mycobacterium avium complex (MAC) bacteria in AIDS patients. METHODS: Inclusion criteria: HIV-positive individuals with at least one CD4+ count &lt; 100 cells/mm³. Exclusion criteria: Mycobacterial disease and MAC prophylaxis. Stool, sputum, and blood cultures were prospectively obtained every month from September, 1997, to December, 1999. The incidence was calculated using Poisson regression. Survival was estimated by the Kaplan Meier method and the Cox proportional hazard model. RESULTS: We followed-up 79 patients during a median period of 428 days. Blood cultures (n = 742) were negative for all mycobacteria. Positive cultures...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DMAC; Colonization; AIDS; Mycobacteria.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500006

Low prevalence of hepatitis B and C markers in a Non-Amazonian indigenous population
Provedor de dados: 55
Autores: Aguiar,José Ivan; Souza,Juberty Antonio de; Aguiar,Eliana Setti; Oliveira,Jaqueline M.; Lemos,Elba R. S. de; Yoshida,Clara F. T.
Tipo: Info:eu-repo/semantics/other
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500010

Low prevalence of human immunodeficiency virus and hepatitis C virus co-infection in a medium size city in southern Brazil
Provedor de dados: 55
Autores: Librelotto,Carina Sperotto; Simon,Daniel; Ikuta,Nilo; Lunge,Vagner Ricardo.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600689

Low prevalence of syphilis in Brazilian inmates
Provedor de dados: 55
Autores: Coelho,Harnoldo Colares; Passos,Afonso Dinis Costa.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100020

Low prevalence of vancomycin resistant enterococci colonization in intensive care patients in a Brazilian teaching hospital
Provedor de dados: 55
Autores: Tresoldi,Antonia T.; Cardoso,Luis Gustavo O.; Castilho,Giane V.; Dantas,Sônia R. P. E.; von Nowakonski,Angela; Pereira,Ricardo M.; Trabasso,Plínio.
Vancomycin-resistant enterococci (VRE) are important pathogens involved in nosocomial infections. Colonization precedes infection and the number of colonized individuals is about 10 times higher than the number of infected patients. We examined VRE colonization in two intensive care units from October 2003 to June 2004. Perirectal swab specimens were obtained from all patients, starting on the 5th day after admission, and then weekly. A total of 249 swabs were obtained from 112 patients. Nine patients had VRE-positive swabs, giving a positive rate of 8.0%. The rate of patients colonized by V-R E. faecalis was 1.8% (n=2), 4.5% by V-R E. gallinarun (n=5) and 1.8% by V-R E. casseliflavus (n=2). No V-R E. faeciun was isolated. None of the patients that had...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin-resistant enterococci; VRE; Colonization.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400004

Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China
Provedor de dados: 55
Autores: Huang,Fen; Ma,Tianwu; Li,Li; Zeng,Weikun; Jing,Shenrong.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600017

Low seroprevalence of Zika virus in Cameroonian blood donors
Provedor de dados: 55
Autores: Gake,Bouba; Vernet,Marie A.; Leparc-Goffart,Isabelle; Drexler,Jan Felix; Gould,Ernest A.; Gallian,Pierre; Lamballerie,Xavier de.
Abstract A Zika virus seroepidemiology study was performed in 1084 blood donors collected from August to October 2015 in six sites of Cameroon representing a large panel of eco-environments. Samples were tested using an anti-NS1 IgG ELISA detection kit and positives were further confirmed by seroneutralization. The observed global seroprevalence was low (around 5%, peaking at 10% and 7.7% in Douala and Bertoua, respectively) with risk factors associated with seropositivity pointing to the existence of a local (peri-)sylvatic cycle of transmission. These results call attention to the potential introduction and subsequent spread in African urban areas of Asian genotype Zika virus currently circulating in the Americas and adapted to transmission by...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Zika virus; Seroprevalence; Africa.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400481

Low tetanus-diphtheria-acellular pertussis (Tdap) vaccine coverage among healthcare workers in a quaternary university hospital in São Paulo, Brazil: need for continuous surveillance and implementation of active strategies
Provedor de dados: 55
Autores: Randi,Bruno Azevedo; Miyaji,Karina Takesaki; Lara,Amanda Nazareth; Ibrahim,Karim Yaqub; Infante,Vanessa; Rodrigues,Camila Cristina Martines; Lopes,Marta Heloísa; Sartori,Ana Marli Christovam.
Abstract  Introduction: Vaccination with tetanus-diphtheria-acellular pertussis (Tdap) has been recommended for healthcare workers (HCWs) by Brazilian Ministry of Health since November 2014.  Objective: To describe the strategies implemented to improve Tdap uptake, cumulative vaccine coverage after each intervention, variables associated to Tdap vaccination, and reasons for non-vaccination among HCWs of the main building of a quaternary hospital attached to the Sao Paulo University Medical School.  Methods: A list of HCWs eligible for pertussis vaccination was generated. From April to December 2015, the following interventions were implemented: note on intern journal reminding the importance of pertussis vaccination; email to the head nurses strengthening...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pertussis vaccine; Diphtheria-tetanus-acellular pertussis vaccines; Bordetella pertussis; Whopping cough; Health personnel.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400231

Low variation in initial CD4 cell count in a HIV referral center, in Salvador, Brazil, from 2002 to 2015
Provedor de dados: 55
Autores: Pereira,Marcela Fonseca; Luz,Estela; Martins Netto,Eduardo; Barbosa,Manoel Henrique Fonseca; Brites,Carlos.
ABSTRACT Early initiation of antiretroviral therapy increases the likelihood of effective immune restoration, quality of life, and greater life expectancy for HIV-infected individuals. We evaluated the evolution of mean CD4+ cells count at diagnosis of HIV/AIDS in Salvador, Brazil from 2002 to 2015. We identified HIV/AIDS patients older than 18 years with diagnosis of HIV infection from 2002 to 2015, who had their first laboratory evaluation at Complexo Hospitalar Prof. Edgard Santos, Federal University of Bahia. Initial mean CD4+ cells count and age, over time were evaluated. A total of 1801 patients randomly selected individuals were included in the analysis. Overall mean CD4+ count at diagnosis in the whole period was 279 ± 265, varying from 191 in 2015...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV/AIDS; CD4; Antiretroviral therapy.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300245

Low-dose adrenocorticotropin test in patients with the Acquired Immunodeficiency Syndrome
Provedor de dados: 55
Autores: Wolff,Fernando H.; Nhuch,Claudio; Cadore,Luciana P.; Glitz,Cristina L.; Lhullier,Francisco; Furlanetto,Tania W.
Adrenocortical insufficiency is a serious complication of AIDS. Usually, integrity of the hypothalamo-pituitary-adrenal (HPA) axis in AIDS patients is assessed by measuring basal cortisol levels and cortisol response to 250 mug of ACTH. Recent studies suggest that a lower ACTH dose increases the sensitivity of the procedure. In the present study, we investigated the prevalence of adrenal hypofunction in AIDS patients using a low-dose ACTH test (1 mug), evaluated the clinical characteristics that might suggest this diagnosis, and the diseases and/or drugs that could be associated with it. We prospectively evaluated 63 very ill AIDS patients and 16 normal controls. A standard examination assessed the presence of signs and symptoms of adrenal insufficiency....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Adrenal insufficiency; ACTH; Cortisol.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200002

Lupus vulgaris in a pediatric patient: a clinicohistopathological diagnosis
Provedor de dados: 55
Autores: Afsar,F. Sule; Afsar,Ilhan; Diniz,Gulden; Asilsoy,Suna; Sorguc,Yelda.
Lupus vulgaris is the most common form of cutaneous tuberculosis which usually occurs in patients previously sensitized to Mycobacterium tuberculosis. We present a case of a 10-year-old boy who was diagnosed as lupus vulgaris clinically and histopathologically. He had well demarcated, irregularly bordered, pink, infiltrated plaques on his left cheek showing apple-jelly appearance on diascopy. The histopathological examination showed tuberculoid granulomas with Langhans type giant cells. The Mantoux reactivity was in normal limits, and no acid-fast bacilli was found in the lesion, either by direct stained smears or by culture. The lesions showed marked improvement on anti-tuberculosis treatment. We want to emphasize that histopathological examination has...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lupus vulgaris; Histopathology; Clinical appearance; Culture.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200011

Lyme disease in the state of Tocantins, Brazil: report of the first cases
Provedor de dados: 55
Autores: Carranza-Tamayo,César Omar; Costa,José Nilton Gomes da; Bastos,Whisllay Maciel.
Lyme disease is an underdiagnosed zoonosis in Brazil. There are no cases registered in the state of Tocantins, the newest Brazilian state. The cases of three patients in contact with rural areas in three Tocantins' districts are herein described, and the Brazilian literature is reviewed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Lyme disease; Tocantins; Brazil.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600015

Lymphocytic myocarditis at autopsy in patients with dengue fever
Provedor de dados: 55
Autores: Torres,Alba Fabiola; Braga,Deborah Nunes; Muniz,Felipe; Mendonça,Cindy; Oliveira,Denise Nunes; Souza,Emilia Tome de; Burke,Allen; Tavora,Fabio.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500020

Magnetic bead technology for viral RNA extraction from serum in blood bank screening
Provedor de dados: 55
Autores: Albertoni,Guilherme Ambrozio; Arnoni,Carine Prisco; Araujo,Patricia Regina Barboza; Andrade,Sheila Siqueira; Carvalho,Fabrício Oliveira; Girão,Manoel João Batista Castello; Schor,Nestor; Barreto,José Augusto.
Nucleic acid amplification testing (NAT) was recently recommended by Brazilian legislation and has been implemented at some blood banks in the city of São Paulo, Brazil, in an attempt to reduce blood-born transmission of human immunodeficiency virus (HIV) and hepatitis C virus. OBJECTIVE: Manual magnetic particle-based extraction methods for HIV and HCV viral nucleic acids were evaluated in combination with detection by reverse transcriptase - polymerase chain reaction (RT-PCR) one-step. METHODS: Blood donor samples were collected from January 2010 to September 2010, and minipools of them were submitted to testing. ELISA was used for the analysis of anti-HCV/HIV antibodies. Detection and amplification of viral RNA was performed using real-time PCR....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; HIV; Infection; Reverse transcriptase polymerase chain reaction; Blood banks.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600008

Maintenance treatment for the modulation of liver fibrosis
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de; Barone,Antonio Alci.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700017

Malaria diagnosis: still a challenge in non-endemic countries
Provedor de dados: 55
Autores: Voulgaridi,Ioanna; Koufakis,Theocharis; Ntava,Evdokia; Zisis,Nikolaos; Tsiakalou,Maria.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400410

Malaria in Southern Brazil: a potential threat for a non-endemic region
Provedor de dados: 55
Autores: Moreira,Daisson L.; Cardoso,Jader C.; Deboni,Sandra C.; Falci,Diego R.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600678

Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes
Provedor de dados: 55
Autores: Baltadzhiev,Ivan; Popivanova,Nedialka; Zaprianov,Zaprian.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500511

Management of acute viral encephalitis in Brazil
Provedor de dados: 55
Autores: Domingues,Renan Barros; Teixeira,Antônio Lúcio.
The appropriate management of acute viral encephalitis is a challenge. Clinical picture includes general symptoms and a wide range of neurological signs. Etiological diagnosis cannot be performed only by clinical means and depends on neuroimaging studies and cerebrospinal fluid molecular analyses. It is recommended since some of these viruses are treatable and that the prognoses of these infections depend on the prompt administration of antiviral and/or immunomodulatory drugs. The management of acute viral encephalitis in Brazil has some peculiarities. First, the etiological distribution of the viral encephalitis may differ from what is found in other countries. Some viruses, such as dengue virus, are more common in Brazil than in developed countries while...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute viral encephalitis; Cerebrospinal fluid; Neuroimaging; Clinical management.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600009

Mask-wearing and respiratory infection in healthcare workers in Beijing, China
Provedor de dados: 55
Autores: Yang,Peng; Seale,Holly; MacIntyre,C Raina; Zhang,Haiyan; Zhang,Zhen; Zhang,Yi; Wang,Xiaoli; Li,Xinyu; Pang,Xinghuo; Wang,Quanyi.
OBJECTIVES: The aim of the study was to determine rates of mask-wearing, of respiratory infection and the factors associated with mask-wearing and of respiratory infection in healthcare workers (HCWs) in Beijing during the winter of 2007/2008. METHODS: We conducted a survey of 400 HCWs working in eight hospitals in Beijing by face to face interview using a standardized questionnaire. RESULTS: We found that 280/400 (70.0%) of HCWs were compliant with mask-wearing while in contact with patients. Respiratory infection occurred in 238/400 (59.5%) subjects from November, 2007 through February, 2008. Respiratory infection was higher among females (odds ratio [OR], 2.00 [95% confidence interval {CI}, 1.16-3.49]) and staff working in larger hospitals (OR, 1.72...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Masks; Respiratory tract infections; Health personnel.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200002

Measles in children with HIV infection: report of five cases
Provedor de dados: 55
Autores: Carvalho,Vânia de; Marinoni,Leide Parolin; Martins,Luzilma Flenick; Taniguchi,Kerstin; Cruz,Cristina Rodrigues da; Bertogna,Jeanine; Fillus Neto,José.
Patients with AIDS have a high incidence of skin problems due to the immunosuppression and malnourishment that are inherent to the progression of this disease. Clinical manifestation of these skin lesions and their severity are different in AIDS patients. We made a prospective study of five cases of measles in children with HIV infection during a community outbreak, and there were typical as well as atypical forms of the disease, including one case with negative serology. There were pulmonary complications, but none of the patients died. The anti-retroviral treatment may have contributed to the decrease in measles morbidity in these pediatric AIDS patients.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; Measles; Children.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500010

Measles outbreak in Brazil, 2018
Provedor de dados: 55
Autores: Goldani,Luciano Z.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500359

Measles, rubella, mumps and Toxoplasma gondii antibodies in saliva of vaccinated students of schools and universities in São Paulo City, Brazil
Provedor de dados: 55
Autores: Sampaio,Barbara Carvalho Fialho; Rodrigues,Jaqueline Polizeli; Meireles,Luciana Regina; Andrade Junior,Heitor Franco de.
ABSTRACT  Introduction: Vaccines are well-established public health interventions with major impacton the prevalence of infectious diseases, but outbreaks are occurring frequently due to pri-mary and secondary failures, despite high coverage. Surveillance of efficacy and duration ofinduced immunity is a difficult task as it requires invasive blood sampling in children andteenagers. Saliva can be an acceptable alternative source of IgG to assess vaccine efficacyand toxoplasmosis incidence. We investigated IgG response for measles, mumps, rubella,and T. gondii in saliva samples of vaccinated young people.  Methods: Saliva was collected from 249 public schools students from São Paulo, Brazil, aged7 to 13 years old, during an interactive exhibition on hygiene....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaccine; Prevalence; Non-invasive; Saliva; IgG; Toxoplasmosis.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100051

Measurement of peripheral blood mononuclear cells producing IFN-Gamma in patients with tuberculosis
Provedor de dados: 55
Autores: Andrade Júnior,Dahir Ramos de; Santos,Sânia Alves dos; Andrade,Dahir Ramos de.
The type of immune response induced by tuberculosis (Th1 or Th2) and its correlation with the clinical outcome is unclear. We studied 13 patients with active tuberculosis (TBC). The peripheral blood mononuclear cells producing IFN-gamma (PBMC-IG) were measured by enzyme-linked immunospot (ELISPOT) technique. The control group had ten healthy individuals vaccinated against tuberculosis. We collected blood samples of each patient in two moments: a) in the hospital admission without treatment (TBC1); b) after seven to 20 days of treatment (TBC2). The comparison of the spots forming units of PBMC-IG between TBC group and controls showed that there was a significant difference between TBC1 and control group (p &lt; 0.001) and between TBC2 and control group (p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Th1 immune response; ELISPOT.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200005

Medical dental prophylaxis of endocarditis
Provedor de dados: 55
Autores: Basilio,Regina C.; Loducca,Francisco E.; Haddad,Paulo C.
Antibiotics have long been the main reason for the increase in man's longevity. Since their discovery, man has tried to reduce the level of infection by treating with antibiotics. At the same time, prophylactic use has been suggested, although this is controversial. Their routine use is not recommended, and empirical treatments at non-therapeutic doses, and indiscriminately, should be avoided, because they may become dangerous and harmful, causing among other things, the prevalence of resistant microorganisms and the eventual potentiation of an increase in morbid states. Infectious endocarditis is a systemic pathology that can start with a bacteremia, which comes either from dental procedures or/and chronic processes that already existed. Its etiopathogeny...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Endocarditis; Prophylaxis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500002

Membranous glomerulonephritis secondary to syphilis
Provedor de dados: 55
Autores: Araújo,Stanley de Almeida; Giordano,Luiz Flávio; Rosa,Ariel Augusto de Britto; Carmo,Paula Alves Santos do; Honorato-Sampaio,Kinulpe.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400442

Memory: tribute to a master
Provedor de dados: 55
Autores: Focaccia,Roberto.
Tipo: Info:eu-repo/semantics/report
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600013

Meningitis caused by Alcaligenes xylosoxidans in a patient with HIV/AIDS
Provedor de dados: 55
Autores: Espinoza-Gómez,F.; Newton-Sánchez,O.A.; Melnikov,V.; Virgen-González,O.; Unrau,J.
The purpose of the present work was to inform about the first case of meningitis associated to the bacteria Alcaligenes xylosoxidans in a patient with HIV/AIDS. The patient was a 46-year-old male, with the antecedent of have been diagnosed for HIV/ AIDS, who attended in the Hospital Universitario de Colima, Mexico, with fever, shock and meningismus. The study of the cerebrospinal fluid showed pleocytosis, elevated protein levels and hypoglycorrhachia. The culture yielded the presence of Alcaligenes xylosoxidans with sensitivity to ciprofloxacin. After 14 days of treatment with this antibiotic, the patient showed neurologic improvement and was able to continue with his outpatient antiretroviral treatment. The present case shows the importance of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meningitis; Alcaligenes xylosoxidans; HIV/AIDS.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600015

Meningitis due to Enterobacter aerogenes subsequent to resection of an acoustic neuroma and abdominal fat graft to the mastoid
Provedor de dados: 55
Autores: Khan,Fida A.
Meningitis is an uncommon complication of neurosurgical procedures, with an incidence of 1.1% to 2.5%. Although unusual, the frequency of nosocomial Gram-negative meningitis appears to be increasing. Gram-negative meningitis has been documented following disruption of the dura-arachnoid barrier secondary to trauma or surgery. The association of Gram-negative bacillary meningitis with neurosurgical procedures was first reported in the 1940's. Wolff et al. described the association between Enterobacter species and post-neurosurgical infection. More recently, risk factors for nosocomial Enterobacter meningitis have been characterized by Parodi et al. Adipose graft, as an independent risk factor has not yet been reported. A patient with acoustic neuroma...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Enterobacter; Meningitis; Neuroma and translabyrinthine resection.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500009

Meningococcal disease before and after the introduction of meningococcal serogroup C conjugate vaccine. Federal District, Brazil
Provedor de dados: 55
Autores: Tauil,Márcia de Cantuária; Carvalho,Cleidiane Santos Rodrigues de; Vieira,Ataiza César; Waldman,Eliseu Alves.
OBJECTIVES: To analyze the behavior of meningococcal disease in the Federal District, Brazil, from 2005 to 2011, and to assess the direct impact of the meningococcal serogroup C conjugate vaccine. METHODS: A descriptive study of cases of meningococcal disease among residents of the Federal District. We included in the study confirmed cases of meningococcal disease reported to the local surveillance. To reduce underreporting we compared data to the Brazilian Mortality Database and the Public Health Laboratory Database. We studied sociodemographic, clinical, and pathogen-related variables. For the assessment of the impact of meningococcal serogroup C conjugate vaccine, which was introduced in 2010 for children under two years of age, we compared the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meningococcal disease; Epidemiology; Control.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400379

Meningoencephalitis and new onset of seizures in a patient with normal brain CT and multiple lesions on MRI
Provedor de dados: 55
Autores: Vidal,José E.; Spichler,Anne; Oliveira,Augusto C. P. de; Lomar,André Villela.
Toxoplasmic encephalitis is the most common cerebral mass lesion in patients with AIDS. The definitive diagnosis requires direct demonstration of the tachyzoite form of Toxoplasma gondii in cerebral tissue. The presumptive diagnosis is based on serology, clinical and radiological features, and on response to anti-Toxoplasma therapy. Typically, patients have a subacute presentation of focal neurological signs, with multiple lesions in computed tomography (CT) or magnetic resonance imaging (MRI). However, the neurological and CT scan spectrum is broad. We report a case of toxoplasmic encephalitis in a heterosexual man without prior history of HIV infection. He was admitted with four days of headache, confusion, and new onset of seizures. His brain CT...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Toxoplasmic encephalitis; Computadorized tomography; Magnetic resonance imaging; Acquired immunodeficiency syndrome.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100010

Meropenem-induced low valproate levels in a cerebral palsy child
Provedor de dados: 55
Autores: Okumura,Lucas Miyake; Andreolio,Cinara; Giorgio,Carla Di; Carvalho,Paulo Roberto Antonacci; Piva,Jefferson Pedro.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400491

Metabolic effects associated to the highly active antiretroviral therapy (HAART) in AIDS patients
Provedor de dados: 55
Autores: Domingos,Hamilton; Cunha,Rivaldo Venâncio da; Paniago,Anamaria Mello Miranda; Martins,Diego Mira; Elkhoury,Eduardo Brandão; Souza,Albert Schiaveto de.
The aim of this study was to evaluate the metabolic abnormalities (dyslipidaemia and insulin resistance) associated with highly active antiretroviral therapy (HAART) in AIDS patients, treated in Campo Grande, Mato Grosso do Sul, Brazil. The patients were distributed in five different groups: Group 1, HIV-infected without antiretroviral therapy; Group 2, with Zidovudine, Lamivudine and Efavirenz or Nevirapine; Group 3, with Zidovudine, Lamivudine and Protease Inhibitor; Group 4, with Stavudine, Lamivudine and Efavirenz or Nevirapine; and Group 5, with Stavudine, Lamivudine and Protease Inhibitor. The lipid and glucose profile were determined and statistics comparison was made. The findings of this study showed significant statistics elevations of total...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HAART; Metabolic effects; Dyslipidaemia; Insulin resistance.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200012

Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART
Provedor de dados: 55
Autores: Cahn,P; Leite,O; Rosales,A; Cabello,R; Alvarez,CA; Seas,C; Carcamo,C; Cure-Bolt,N; L'Italien,Gp; Mantilla,P; Deibis,L; Zala,C; Suffert,T.
OBJECTIVE: Determine the prevalence of metabolic abnormalities (MA) and estimate the 10-year risk for cardiovascular disease (CVD) among Latin American HIV-infected patients receiving highly active anti-retroviral therapy (HAART). METHODS: A cohort study to evaluate MA and treatment practices to reduce CVD has been conducted in seven Latin American countries. Adult HIV-infected patients with at least one month of HAART were enrolled. Baseline data are presented in this analysis. RESULTS: A total of 4,010 patients were enrolled. Mean age (SD) was 41.9 (10) years; median duration of HAART was 35 (IQR: 10-51) months, 44% received protease inhibitors. The prevalence of dyslipidemia and metabolic syndrome was 80.2% and 20.2%, respectively. The overall 10-year...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HAART; HIV; Metabolic parameters; Cardiovascular risk factors; Metabolic syndrome; Dyslipidemia.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200008

Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors
Provedor de dados: 55
Autores: Akl,Lívia D.; Valadares,Ana L.R.; Moraes,Monica Jacques de; Pinto-Neto,Aarão M.; Lagrutta,Bianca; Costa-Paiva,Lúcia.
ABSTRACT  Objectives: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women.  Methods: Cross-sectional study including 273 HIV-infected climacteric women of 40-60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters.  Results: Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was &gt;500 cells/mm3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic syndrome; Menopause; HIV; Protease inhibitors.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300263

Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America
Provedor de dados: 55
Autores: Alvarez,C; Salazar,R; Galindez,J; Rangel,F; CastaÃ±eda,ML; Lopardo,G; Cuhna,CA; Roldan,Y; Sussman,O; Gutierrez,G; Cure-Bolt,N; Seas,C; Carcamo,C; Castrillo,M.
OBJECTIVE: To evaluate the prevalence of and the associated factors for metabolic syndrome (MS) among Latin American HIV-infected patients receiving antiretroviral therapy (ART) using baseline data from the RAPID II study. METHODS: A longitudinal study to evaluate the metabolic profile, cardiovascular disease (CVD) risk and associated treatment practices to reduce this risk has been conducted in seven Latin American countries (the RAPID II study). Adult HIV patients with at least six months of RT were enrolled. MS was defined following ATP-III criteria. Demographic and anthropometric data, serum biochemical and clinical parameters were compared in patients with and without MS using bivariate and multivariate analysis. RESULTS: A total of 4,010 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic syndrome (MS); HIV; ART; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300010

Metallo-β-lactamase and genetic diversity of Pseudomonas aeruginosa in intensive care units in Campo Grande, MS, Brazil
Provedor de dados: 55
Autores: Rodrigues,Ana Claudia Souza; Chang,Marilene Rodrigues; Nóbrega,Gabriela Dorn; Rodrigues,Mayara Souza; Carvalho,Nadia Cristina Pereira; Gomes,Beatriz Garcia; Almeida,Dênio Lopes de; Carvalho,Karyne Rangel; Asensi,Marise Dutra.
Infection by Pseudomonas aeruginosa has spread worldwide, with limited options for treatment. The purpose of this study was to investigate metallo-β-lactamase-producing P. aeruginosa strains and compare their genetic profile using samples collected from patients in intensive care units. Forty P. aeruginosa strains were isolated from two public hospitals in Campo Grande, Mato Grosso do Sul State, from January 1st, 2007 to June 31st, 2008. Profiles of antimicrobial susceptibility were determined using the agar diffusion method. Metallo-β-lactamase was investigated using the double-disk diffusion test and PCR. Molecular typing was performed by pulsed-field gel electrophoresis (PFGE). Respiratory and urinary tracts were the most common isolation sites. Of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa drug resistance; Multiple beta-lactamases electrophoresis gel pulsed-field.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300002

Metallo-β-lactamase-producing Pseudomonas aeruginosa in two hospitals from southern Brazil
Provedor de dados: 55
Autores: Wirth,Fernanda W.; Picoli,Simone U.; Cantarelli,Vlademir V.; Gonçalves,Ana L.S.; Brust,Flávia R.; Santos,Liege M.O.; Barreto,Michelle F.
This study determined the prevalence of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in two hospitals located in the Southern part of Brazil and compare the performance of two different phenotypic tests. Thirty-one non-repetitive Pseudomonas aeruginosa isolates from various clinical samples from patients admitted to two hospitals located in Rio Grande do Sul, Brazil (twenty-three from a hospital in Porto Alegre City and eight isolates from a hospital in Vale dos Sinos Region). All strains suggestive of possessing MBLs by phenotypic methods were included in this study. Phenotypic detection of MBLs was carried out simultaneously by using both the MBL Etest® and disk approximation test using 2-mercaptopropionic acid close to a ceftazidime disk....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metallo-beta-lactamase; Pseudomonas aeruginosa; Multiresistance.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300003

Methemoglobinemia and dapsone levels in patients with leprosy
Provedor de dados: 55
Autores: Vieira,Jose Luiz Fernandes; Riveira,Juan Gonzalo Bardarez; Martins,Ana de Nazaré Silva; Silva,Jorge Pereira da; Salgado,Claudio Guedes.
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191%, and in female was 2.84 ± 1.67%. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Methahemoglobinemia; Dapsone; Leprosy.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300022

Methicillin/Oxacillin-resistant Staphylococcus aureus as a hospital and public health threat in Brazil
Provedor de dados: 55
Autores: Carvalho,Karinne Spirandelli; Mamizuka,Elsa Masae; Gontijo Filho,Paulo P.
Methicillin-resistant Staphylococcus aureus is an established nosocomial pathogen (HA-MRSA, hospital acquired MRSA), but has recently begun to appear in the community (CA-MRSA, community acquired MRSA). The cause of resistance to methicillin and all other β-lactam antibiotics is the mecA gene, which is situated on a mobile genetic element, the Staphylococcal Cassette Chromosome mec (SCCmec). Seven major variants of SCCmec, type I to VII are distinguished. HA-MRSA disseminated worldwide and causes the majority of S. aureus nosocomial infections with a limited number of clones disseminated including the Brazilian Epidemic Clone (BEC, ST239-MRSA-III). CA-MRSA isolates are susceptible to non-β-lactam antibiotics, usually isolated from healthy individuals which...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Methicillin-resistant Staphylococcus aureus; Community acquired methicillin-resistant Staphylococcus aureus; Nosocomial infections and community infections.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100014

Methicillin-resistant and methicillin-susceptible community-acquired Staphylococcus aureus infection among children
Provedor de dados: 55
Autores: Gomes,Renata Tavares; Lyra,Ticiana Goyanna; Alves,Noraney Nunes; Caldas,Renilza Menezes; Barberino,Maria-Goreth; Nascimento-Carvalho,Cristiana Maria.
Methicillin-resistant Staphylococcus aureus has emerged as a pathogen associated with community-acquired infections worldwide. We report the spectrum of community-acquired S. aureus infections and compare the patients infected with methicillin-susceptible or methicillin-resistant strains among patients aged &lt;20 years. Overall, 90 cases of community acquired S. aureus were detected in an 11-year period. Clinical and microbiological data were registered. Fifty-nine (66%) patients were male and the median age was two years. The majority (87%) of the patients were hospitalized and chronic underlying illnesses were detected in 27 (30%) cases. Overall, 34 (37.8%) patients had skin/soft tissue infections and 56 (62.2%) patients had deep-seated infection. Four...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial agents; Community-acquired infection; Methicillin resistance; Staphylococcal infections; Staphylococcus aureus antimicrobial; Resistance.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500010

Methicillin-resistant Staphylococcus aureus isolated from an intensive care unit in Minas Gerais, Brazil, over a six-year period
Provedor de dados: 55
Autores: Nascimento,Thiago C.; Diniz,Cláudio G.; Silva,Vânia L.; Ferreira-Machado,Alessandra B.; Fajardo,Marina O.; de Oliveira,Tamara Lopes R.; Ferreira,Dennis de C.; Cavalcante,Fernanda S.; Santos,Kátia R. Netto dos.
ABSTRACT To characterize methicillin-resistant Staphylococcus aureus isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 isolates were recovered from patients admitted to the intensive care unit in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97.7%), rifampin (88.8%), and gentamycin (86.6%). The SCCmec typing revealed that the isolates harbored the types III (66.7%), II (17.8%), IV (4.4%), and I (2.2%). Four (8.9%) isolates carried non-typeable cassettes. Most (66.7%) of the isolates were related to the Brazilian endemic clone from CC8/SCCmec III, which was prevalent (89.3%) between 2005 and 2007,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Clonal complex; MRSA; PFGE lineages; SCCmec.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100055

Methicillin-resistant Staphylococcus aureus nasal carriage in neonates and children attending a pediatric outpatient clinics in Brazil
Provedor de dados: 55
Autores: Vieira,Maria Aparecida; Minamisava,Ruth; Pessoa-Júnior,Vicente; Lamaro-Cardoso,Juliana; Ternes,Yves Mauro; Andre,Maria Cláudia Porfirio; Sgambatti,Sabrina; Kipnis,André; Andrade,Ana Lúcia.
Background:In Latin America, few studies have been carried out on methicillin-resistant Staphylococcus aureus carriage in the pediatric population. We conducted a survey of nasal S. aureus carriage in neonates and in children attending the pediatric outpatient clinics in a large Brazilian city with high antimicrobial consumption.Methods:Pernasal swabs of neonates were collected upon admission and at discharge in four neonatal intensive care units and of children less than five years of age during outpatient visits. Methicillin-resistant S. aureus isolates were characterized for antibiotic susceptibility, mec gene presence, pulsed-field gel electrophoresis, spatype, SCCmec-type, multilocus sequence type, and presence of Panton-Valentine leukocidin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus carriage; Methicillin-resistant Staphylococcus; Aureus; Neonates; Children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100042

Methicillin-resistant Staphylococcus lugdunensis carrying SCCmec type V misidentified as MRSA
Provedor de dados: 55
Autores: Pereira,Eliezer Menezes; Schuenck,Ricardo Pinto; Nouér,Simone Aranha; Santos,Kátia Regina Netto dos.
Staphylococcus lugdunensis is a rare cause of severe infections and clinical manifestations are similar to those related to S. aureus infection. We describe a hospital-acquired bacteremia due to methicillin-resistant Staphylococcus lugdunensis, misidentified as methicillin-resistant S. aureus. The oxacillin MIC was 16 µg/mL and the mecA gene and SCCmec type V were determined by PCR. Although treatment had been appropriated, the patient died after rapid progressive respiratory failure and another nosocomial sepsis. It is important not only to identify S. lugdunensis in view of its clinical course, but also to determine its susceptibility to oxacillin by detecting the mecA gene or its product.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Staphylococcus; Methicillin resistance; Bacteremia.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300020

Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection
Provedor de dados: 55
Autores: Hua,Wenhao; Zhang,Guanbin; Guo,Shujun; Weijie,Li; Sun,Lanhua; Xiang,Guangxin.
Background: Research has shown that hepatitis B virus (HBV) genotypes are closely linked to the clinical manifestations, treatment, and prognosis of the disease.Objective: To study the association between genotype and drug-resistant HBV mutations in 620 Chinese patients with chronic HBV infection.Methods: HBV DNA levels were determined using real-time quantitative PCR in plasma samples. Microarrays were performed for the simultaneous detection of HBV genotypes (HBV/B, C, and D) and drug-resistance-related hotspot mutations. A portion of the samples analyzed using microarrays was selected randomly and the data were confirmed using direct DNA sequencing.Results: Most samples were genotype C (471/620; 76.0%), followed by genotype B (149/620; 24.0%). Among the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic HBV; Microarray; Genotyping; Drug-resistance mutations.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300291

Microbial contamination of single-and multiple-dose vials after opening in a pulmonary teaching hospital
Provedor de dados: 55
Autores: Baniasadi,Shadi; Dorudinia,Atosa; Mobarhan,Mandana; Gamishan,Masoumeh Karimi; Fahimi,Fanak.
OBJECTIVES: Intravenous therapy is a complex procedure usually requiring the preparation of the medication in the clinical area before administration to the patient. Breaches in aseptic technique may result in microbial contaminations of vials which is a potential cause of different avoidable infections. We aimed to investigate the prevalence and pattern of microbial contamination of single- and multiple-dose vials in the largest pulmonary teaching hospital in Iran. METHODS: In a period of 2 months, opened single- and multiple-dose vials from different wards were sampled by a pharmacist. The name of the medication, ward, labeling of the vials, the date of opening, and storing temperature were recorded for each vial. Remained contents of each vial were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hospital; Infection control; Injection; Intravenous.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100011

Microbial investigation of biofilms recovered from endotracheal tubes using sonication in intensive care unit pediatric patients
Provedor de dados: 55
Autores: Ferreira,Thiago de Oliveira; Koto,Rafael Yoshio; Leite,Gabriel Fialkovitz da Costa; Klautau,Giselle Burlamaqui; Nigro,Stanley; Silva,Cely Barreto da; Souza,Ana Paula Idalgo da Fonseca; Mimica,Marcelo Jenne; Cesar,Regina Grigolli; Salles,Mauro José Costa.
Abstract  Objectives To compare cultured microorganisms identified on endotracheal tubes biofilms through sonication technique with traditional tracheal aspirate collected at extubation of pediatric intensive care unit patients.  Methods Demographic and epidemiological data were analyzed to identify factors possibly related with the microbiological profile of the two collection methods. Associations between categorical and continuous variables were analyzed using the chi-square or Fisher's exact test, or Student's t test. p-Value &lt;0.05 were considered significant.  Results Thirty endotracheal tubes and tracheal aspirates samples from 27 subjects were analyzed. Only one patient presented the clinical diagnosis of ventilator-associated pneumonia. Overall,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sonication; Endotracheal tube; Biofilm; Tracheal aspirate.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500468

Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Barroso,David Eduardo; Carvalho,DM; Casagrande,ST; Rebelo,MC; Soares,V; Zahner,V; Solari,CA; Nogueira,SA.
The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Meningococcal disease; Epidemic; Meningitis; Sepsis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300008

Microbiology and clinical characteristics of viridans group streptococci in patients with cancer
Provedor de dados: 55
Autores: Guerrero-Del-Cueto,Fuensanta; Ibanes-Gutiérrez,Cyntia; Velázquez-Acosta,Consuelo; Cornejo-Juárez,Patricia; Vilar-Compte,Diana.
ABSTRACT This study assessed the microbiology, clinical syndromes, and outcomes of oncologic patients with viridans group streptococci isolated from blood cultures between January 1st, 2013 and December 31st, 2016 in a referral hospital in Mexico using the Bruker MALDI Biotyper. Antimicrobial sensitivity was determined using BD Phoenix 100 according to CLSI M100 standards. Clinical information was obtained from medical records and descriptive analysis was performed.Forty-three patients were included, 22 females and 21 males, aged 42 ± 17 years. Twenty (46.5%) patients had hematological cancer and 23 (53.5%) a solid malignancy. The viridans group streptococci isolated were Streptococcus mitis, 20 (46.5%); Streptococcus anginosus, 14 (32.6%); Streptococcus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Viridans group streptococci; Bacteremia; Bloodstream infection; Cancer; Mucosal damage.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400323

Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia - Brazil
Provedor de dados: 55
Autores: Tunes,Alessandro; Reis,Joice Neves; Terse,Regina; Santana,Maria Angélica; Diniz,Ana Lúcia; Barros,Tânia Fraga; Leal,Ana Karina Souza; Paixão,Vilma; Grassi,Maria Fernanda Rios.
Lower airway infection is a major cause of morbidity and mortality in patients with cystic fibrosis. It is currently unknown if the infection of the upper airway can cause exacerbation of lower respiratory tract infection. This study aimed to determine the microbiological profile of the anterior paranasal sinuses outflow tract (middle meatus) of cystic fibrosis outpatients. The microbiological profile was defined using endoscopically directed middle meatal cultures. Paired middle meatal and sputum specimens were collected from 56 outpatients for aerobic cultures. A semi-quantitative leukocyte count of the middle meatal samples was performed. The median age of patients was nine years (3-20 years). Staphylococcus aureus (37%),...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cystic fibrosis; Middle meatus; Infection; Endoscopy.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200215

Microflora of bile aspirates in patients with acute cholecystitis With or without cholelithiasis: a tropical experience
Provedor de dados: 55
Autores: Capoor,Malini R.; Nair,Deepthi; Rajni,; Khanna,Geetika; Krishna,S.V.; Chintamani,M.S.; Aggarwal,Pushpa.
The current study determined the spectrum of biliary microflora with special emphasis on enteric fever organisms in patients with acute cholangitis with and without cholelithiasis or other biliary diseases. The patients were divided into three groups: Group A consisted of patients with acute cholecystitis with cholelithiasis; Group B consisted of patients with acute cholecystitis with gastrointestinal ailments requiring biliary drainage and group C consisted of patients with gallbladder carcinoma. Gallbladder, bile and gallstones were subjected to complete microbiological and histopathological examination. Antimicrobial susceptibility of the isolates was performed as per CLSI guidelines. Bacteria were recovered from 17 samples (32%) in Group A, 17 (51.4%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bile; Acute cholecystitis; Salmonella enretica serovar Typhi.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300012

Microsporum spp. onychomycosis: disease presentation, risk factors and treatment responses in an urban population
Provedor de dados: 55
Autores: Martínez,Erick; Ameen,Mahreen; Tejada,Diana; Arenas,Roberto.
BACKGROUND:Dermatophytes are the main causative agent of all onychomycosis, but genus Microsporum is infrequent and the risk of acquiring the infection is often associated with exposure to risk factors.OBJECTIVES:To describe clinical characteristics of onychomycosis due to Microsporum onychomycosis in an urban population.METHODS:This was a retrospective analysis of the epidemiological and clinical features of 18Microsporum onychomycosis cases of a total of 4220 of onychomycosis cases diagnosed between May 2008 and September 2011 at the tertiary referral center for mycology in Guatemala.RESULTS:Eighteen cases of Microsporum onychomycosis (M. canis, n=10; M. gypseum, n=7; M. nanum, n=1) were identified (prevalence=0.43%). Infection was limited to nails only...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Onychomycosis; Dermatophytes; Microsporum.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200181

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum
Provedor de dados: 55
Autores: Khademvatan,Shahram; Gharavi,Mohammad Javad; Saki,Jasem.
OBJECTIVES: Apoptosis is the process of programmed cell death (PCD) that occurs in both animal and plant cells. Protozoan parasites possess metacaspase and these caspase-related proteases could be involved in the PCD pathways in these organisms. Therefore we analyzed the activities of metacaspase and PARP genes in Leishmania infantum (MCAN/IR/96/LON49) treated with miltefosine. MATERIALS AND METHODS: Anti-leishmania activity of miltefosine was studied by treatment of cultured promastigotes with various concentration of miltefosine. MTT assay and Annexin-V FLUOS staining by using FACS flow cytometry methods were used. Cytotoxic potential of HePC on the amastigots of L.infantum was evaluated in J774 cell line. In addition, metacaspase and PARP genes...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania infantum; Apoptosis; Gene expression.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500005

Mimotopes selected by biopanning with high-titer HIV-neutralizing antibodies in plasma from Chinese slow progressors
Provedor de dados: 55
Autores: Zhang,Xiaoli; Han,Xiaoxu; Dai,Di; Mingjia,Bao; Zhang,Zining; Zhang,Min; Bice,Tristan; Zhao,Min; Cao,Yaming; Shang,Hong.
OBJECTIVE: One approach to identifying HIV-1 vaccine candidates is to dissect the natural antiviral immune response in treatment-naïve individuals infected for over ten years, considered slow progressor patients (SPs). It is suspected that SP plasma has strongly neutralizing antibodies (NAb) targeting specific HIV viral epitopes. METHODS: NAbs levels of 11 HIV-1-infected SPs were detected by PBMC-based neutralization assays. To investigate SP NAb epitope, this study used a biopanning approach to obtain mimotopes of HIV-1 that were recognized by SP plasma NAbs. IgG was purified from hightiter NAb SP plasma, and used as the ligand for three rounds of biopanning to select HIV-specific mimotopes from a phage-displayed random peptide library. Double-antibody...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1 vaccine; Slow progressor; Neutralizing antibodies.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600002

Misidentiﬁcation of pan drug-resistant Klebsiella pneumoniae clinical isolates as a metallo-β-lactamase producers by the EDTA/DDST test
Provedor de dados: 55
Autores: Cassu-Corsi,Dandara; Martins,Willames M.B.S.; Scheffer,Mara Cristina; Cayô,Rodrigo; Gales,Ana Cristina.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100102

Missed opportunities for prevention of perinatal HIV infection
Provedor de dados: 55
Autores: Matos,Vanessa Terezinha Gubert De; Oliveira,Ana Lúcia Lyrio De; Santos,Edinéia Ribeiro Dos; Alencar,Susã Kelly da Rocha; Fabbro,Márcia Maria Ferrairo Janini Dal.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500554

Mobile health application to assist doctors in antibiotic prescription - an approach for antibiotic stewardship
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Gasparetto,Juliano; Wollmann,Luciana Cristina; Moraes,Thyago Proença de.
ABSTRACT  Background: Technologies applied to mobile devices can be an important strategy in antibiotic stewardship programs.  Objective: The aim of this study was to determine the impact of a decision-making application on antibiotic prescription.  Methods: This was an observational, analytical and longitudinal study on the implementation of an antimicrobial guide for mobile application. This study analyzed the period of 12 months before and 12 months after the app implementation at a university hospital based on local epidemiology, avoiding high cost drugs and reducing the potential for drug resistance including carbapenem. Antimicrobials consumption was evaluated in Daily Defined Dose/1000 patients-day and direct expenses converted into USD.  Results:...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mobile health applications; Stewardship; Antibiotic; Infection control.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600660

Modulation of cerebral malaria by curcumin as an adjunctive therapy
Provedor de dados: 55
Autores: Jain,Kunal; Sood,Sumeet; Gowthamarajan,K.
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cerebral malaria; Curcumin; Adjunctive; Cognitive deficit.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500011

Modulation of drug resistance and biofilm formation of Staphylococcus aureus isolated from the oral cavity of Tunisian children
Provedor de dados: 55
Autores: Zmantar,Tarek; Ben Slama,Rihab; Fdhila,Kais; Kouidhi,Bochra; Bakhrouf,Amina; Chaieb,Kamel.
Abstract  Objectives: This study aims to investigate the antimicrobial and the anti-biofilm activities of Lactobacillus plantarum extract (LPE) against a panel of oral Staphylococcus aureus (n = 9) and S. aureus ATCC 25923. The in vitro ability of LPE to modulate bacterial resistance to tetracycline, benzalchonium chloride, and chlorhexidine were tested also.  Methods: The minimum inhibitory concentrations (MICs) and the minimal bactericidal concentrations of Lactobacillus plantarum extract, tetracycline, benzalchonium chloride and clohrhexidine were determined in absence and in presence of a sub-MIC doses of LPE (1/2 MIC). In addition, the LPE potential to inhibit biofilm formation was assessed by microtiter plate and atomic force microscopy assays....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial; Staphylococcus aureus; Biofilm; Antibiotics; Synergetic; Lactobacillus.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100027

Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature
Provedor de dados: 55
Autores: Slavov,Svetoslav Nanev; Kashima,Simone; Silva-Pinto,Ana Cristina; Amarilla,Alberto Anastacio; Aquino,Victor Hugo; Covas,Dimas Tadeu.
Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infection outcome.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Human parvovirus B19; Viral load; Aplastic crisis; Subgenotypes.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100017

Molecular characteristics and virulence gene profiles of Staphylococcus aureus causing bloodstream infection
Provedor de dados: 55
Autores: Li,Xuehan; Fang,Fang; Zhao,Jin; Lou,Ning; Li,Chenglin; Huang,Tao; Li,Yirong.
ABSTRACT  Background: The rate of methicillin-resistant Staphylococcus aureus (MRSA) among the total of S. aureus isolates decreased to 35.3% in 2017 in China. It is unclear whether the molecular characteristics of S. aureus isolates have changed as the rate decreased.  Objective: This study aimed to investigate the molecular characteristics and virulence genes profile of S. aureus isolates causing bloodstream infection and analyze the correlation between the prevalence rates of the common sequence types and MRSA.  Methods: A total of 112 S. aureus strains from eight hospitals of four cities, including 32 MRSA isolates, were identified and evaluated through multilocus sequence typing, spa typing, and determination of virulence genes.  Results: Twenty-five...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Methicillin-resistant Staphylococcus aureus (MRSA); Bloodstream infection; Virulence encoding gene; Multilocus sequence typing; Spa typing.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600487

Molecular characteristics of methicillin-resistant Staphylococcus aureus isolates from hospital and community environments in northeastern Brazil
Provedor de dados: 55
Autores: Carvalho,Suzi P. de; Almeida,Jéssica B. de; Andrade,Yasmin M.F.S.; Silva,Lucas S.C. da; Chamon,Raiane C.; Santos,Kátia R.N. dos; Marques,Lucas M.
ABSTRACT This study characterized 30 MRSA isolates from intensive care unit (ICU) environment and equipment surfaces and healthy children. The SCCmec types I, IVa and V were detected in HA-MRSA isolates while CA-MRSA showed the SCCmec type IVa and V. Most isolates were classified as agr group II. All isolates presented the sei gene, and only HA-MRSA were positive for etb e tst genes. Three genotypes were related to Pediatric (ST5/SCCmecIV) and Berlin (ST45/SCCmecIV) clones. The present study showed molecular similarity between CA- and HA-MRSA isolates in hospital and community settings in a Brazilian region.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Methicillin-resistant Staphylococcus aureus; CA-MRSA; HA-MRSA; Molecular typing.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200134

Molecular characterization and epidemiology of cefoxitin resistance among Enterobacteriaceae lacking inducible chromosomal ampC genes from hospitalized and non-hospitalized patients in Algeria: description of new sequence type in Klebsiella pneumoniae isolates
Provedor de dados: 55
Autores: Gharout-Sait,Alima; Touati,Abdelaziz; Guillard,Thomas; Brasme,Lucien; Champs,Christophe de.
In this study, 922 consecutive non-duplicate clinical isolates of Enterobacteriaceae obtained from hospitalized and non-hospitalized patients at Bejaia, Algeria were analyzed for AmpC-type β-lactamases production. The ampC genes and their genetic environment were characterized using polymerase chain reaction (PCR) and sequencing. Plasmid incompatibility groups were determined by using PCR-based replicon typing. Phylogenetic grouping and multilocus sequence typing were determined for molecular typing of the plasmid-mediated AmpC (pAmpC) isolates.Of the isolates, 15 (1.6%) were identified as AmpC producers including 14 CMY-4- producing isolates and one DHA-1-producing Klebsiella pneumoniae . All AmpC-producing isolates co-expressed the broad-spectrum TEM-1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterobacteriaceae; AmpC β-lactamases; Genotyping; Algeria.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200187

Molecular characterization of group A rotavirus isolates obtained from hospitalized children in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Serravalle,Karina; Santos,Norma; Sardi,Silvia Inês; Silva,Sarah Peregrino Santos; Ribeiro Junior,Hugo da Costa; Mattos,Ângela Peixoto de; Campos,Gúbio Soares.
Rotavirus is a major cause of infectious diarrhea in infants and young children. The objective of this study was to characterize the genotypes of Human Rotavirus found in children hospitalized with acute diarrhea in the Pediatric Hospital Prof. Hosannah de Oliveira of the UFBA in Salvador, Bahia, Brazil, during the years of 1999, 2000 and 2002. Fecal samples were analyzed (n=358) by methods EIARA and SDS-PAGE for detection of Rotavirus. Positive samples of one or two of these methods (n=168) were submitted to RT-PCR and Multiplex-Nested PCR to determine genotypes G and P. A hundred sixty-eight (46.9%) samples were positive and 190 (53.1%) negative. Only 17 (4.7%) samples had divergent results. The distribution of genotypes G during the first year, showed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; PCR; Genotype; Children.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100010

Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from a Brazilian university hospital
Provedor de dados: 55
Autores: Martins,André; Riboli,Danilo Flávio Moraes; Pereira,Valéria Cataneli; Cunha,Maria de Lourdes Ribeiro de Souza da.
The aim of this study was to perform SCCmec typing in Staphylococcus aureus isolates and to characterize the clonal profile of these isolates. Forty-six mecA gene-positive strains isolated between 2002 and 2006 were submitted to antimicrobial resistance testing by the E-test, SCCmec typing by multiplex PCR, and clonal profile analysis by pulsed-field gel electrophoresis. Forty-one (89.1%) isolates were typed as SCCmec III and five (10.9%) as SCCmec IV. Four circulating clones were detected, one of them comprising isolates related to the Brazilian epidemic clone. This clone was detected throughout the study period. The SCCmec III isolates were associated with a high rate of multidrug resistance and clonal dissemination of methicillin-resistant S. aureus in...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Staphylococcus aureus; MRSA; SCCmec; BEC.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300331

Molecular characterization of microbial contaminants isolated from Umbilical Cord Blood Units for transplant
Provedor de dados: 55
Autores: Bello-López,Juan Manuel; Noguerón-Silva,Jorge; Castañeda-Sánchez,Jorge Ismael; Rojo-Medina,Julieta.
ABSTRACT Disposal of Umbilical Cord Blood Units due to microbial contamination is a major problem in Cord Blood Banks worldwide as it reduces the number of units available for transplantation. Additionally, economic losses are generated as result of resources and infrastructure used to obtain such units. Umbilical Cord Blood Units that showed initial microbial contamination were subject to strains isolation, identification, and characterization by sequencing the 16S rRNA gene and Enterobacterial Repetitive Intergenic Consensus (ERIC-PCR). Moreover, tests of antimicrobial resistance/sensitivity and phenotypic activities that may play an important role in microbial infection were performed. Microbial contamination was detected in 120 Umbilical Cord Blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Umbilical Cord Blood Units; Microbial contamination; Molecular characterization.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600571

Molecular characterization of the first fluoroquinolone resistant strains of Streptococcus agalactiae isolated in Brazil
Provedor de dados: 55
Autores: Barros,Rosana Rocha; Kegele,Fabíola Cristina Oliveira; Paula,Geraldo Renato de; Brito,Monique Araújo de; Duarte,Rafael Silva.
Three isolates of Streptococcus agalactiae, recovered from residents of the metropolitan area of Rio de Janeiro with significant bacteriuria, were found to be resistant to levofloxacin. Determination of the minimal inhibitory concentration (MIC) confirmed one isolate as intermediate and two as resistant to levofloxacin. No reduction in levofloxacin MIC was observed with reserpine, indicating that resistance was not caused by an efflux mechanism. Typical point mutations were observed in the quinolone resistance determinant region of gyrA and parC. Other point mutations in parC generated novel altered codons: Ser80→Pro in the intermediate resistance isolate, and Gly128→Asp in a resistant isolate. Through molecular modeling, it was possible to observe that...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Fluoroquinolone resistance; Bacteriuria; Genetic diversity; Streptococcus agalactiae.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500013

Molecular characterization of van genes found in vancomycin-resistant Enterococcus spp. isolated from Hospital das Clínicas, FMUSP, São Paulo, Brazil
Provedor de dados: 55
Autores: Caiaffa Filho,H.H.; Almeida,G.D.; Oliveira,G.A.; Sarahyba,L.; Mamizuka,E.M.; Burattini,M.N.
Vancomycin-resistant enterococci strains (VRE) is an important pathogen related with hospital infections in many countries, presenting limited or no therapeutic options for treating serious infections. VRE has presented some different genotypes been VanA and VanB considered to be the most important in hospital environments. In the present study the authors investigated the prevalence of van genes (A, B an C) among clinical isolates of VRE in a five month period at a large tertiary hospital in Sao Paulo, Brazil. The results showed the presence of vanA, but not vanB or vanC in all 43 strains of E. faecalis and five E. faecium studied. The results bring an important issue, due to the possibility of resistance spread of vanA genes, to be monitored and solved...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Enterococci; Vancomycin resistance; Hospital infections.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300001

Molecular characterization of viruses associated with gastrointestinal infection in HIV-positive patients
Provedor de dados: 55
Autores: Silva,Raquel C; Benati,Fabrício J; Pena,Giselle PA; Santos,Norma.
BACKGROUND: Diarrhea is a major cause of morbidity and mortality among HIV-infected patients worldwide. OBJECTIVE: We sought to determine the frequency of viral gastrointestinal infections among Brazilian HIV-infected patients with diarrhea. METHODS: A collection of 90 fecal specimens from HIV-infected individuals with diarrhea, previously tested for the presence of bacteria and parasite was analyzed by polymerase chain reaction and sequence analysis for the presence of enteric viruses such as astrovirus, norovirus, rotavirus groups A, B and C, adenovirus, herpes simplex virus, Epstein-Barr virus, cytomegalovirus, and human bocavirus. RESULTS: Twenty patients (22.2%; n = 90) were infected with parasites (11 single infections and nine coinfected with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV infection; Gastrointestinal disorders; Cytomegalovirus; Human bocavirus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600001

Molecular detection of Bartonella clarridgeiae in domestic cats from Midwest Brazil
Provedor de dados: 55
Autores: Braga,Ísis Assis; Dias,Ingrid Savino de Oliveira; Chitarra,Cristiane Silva; Amude,Alexandre Mendes; Aguiar,Daniel Moura.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400451

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants
Provedor de dados: 55
Autores: Dinc,Bedia; Bozdayi,Gulendam; Biri,Aydan; Kalkanci,Ayse; Dogan,Bora; Bozkurt,Nuray; Rota,Seyyal.
OBJECTIVE: Human cytomegalovirus (CMV) is the most common cause of viral intrauterine infections in the world. Herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. HPV infection has been linked to the majority of the anogenital malignancies. The aim of this study was to detect the existence of CMV, HSV-2 and HPV type 16-18 in Turkish pregnants by using sensitive molecular assays. METHODS: One hundred thirty-four women (18-41 years old; mean age ± SD: 27 ± 8) applied to outpatient clinic of Obstetrics and Gynecology, in between 18th - 22nd weeks of their pregnancy and a control group of 99 healthy women (15-39 years old; mean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnancy; Infection; Polymerase chain reaction.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600005

Molecular detection of Feline Leukemia Virus in free-ranging jaguars (Panthera onca) in the Pantanal region of Mato Grosso, Brazil
Provedor de dados: 55
Autores: Silva,Carla Patricia Amarante e; Onuma,Selma Samiko Miyazaki; de Aguiar,Daniel Moura; Dutra,Valéria; Nakazato,Luciano.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300020

Molecular detection of Mycobacterium leprae by Polymerase Chain Reaction in captive and free-ranging wild animals
Provedor de dados: 55
Autores: Maruyama,Fernanda H.; Morgado,Thais O.; Pacheco,Richard C.; Nakazato,Luciano; Dutra,Valeria.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500445

Molecular diagnosis and genotyping of Neisseria gonorrhoeae in urine samples from women at low-income communities in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Regua-Mangia,Adriana Hamond; Brito,Célia Maria Marques de; Rosa,Rosana Silva; Correa,Mariane Alves; Santos-Périssé,Andre Reynaldo.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100021

Molecular diagnosis of cerebral toxoplasmosis: comparing markers that determine Toxoplasma gondii by PCR in peripheral blood from HIV-infected patients
Provedor de dados: 55
Autores: Mesquita,Rafael Tonini; Vidal,José Ernesto; Pereira-Chioccola,Vera Lucia.
As cerebral toxoplasmosis is the most common cerebral focal lesion in AIDS patients, this study evaluated three PCR markers for diagnosis, since some limitations remain present, such as low parasite levels in some clinical samples. The molecular markers were B22-B23 and Tg1-Tg2 (based on the B1 gene) and Tox4-Tox5 (non-coding fragment, repeated 200-300-fold). DNA samples from 102 AIDS patients with previously known diagnosis were analyzed. The cerebral toxoplasmosis group was constituted of DNA extracted from the blood of 66 AIDS patients, which was collected before or until the third day of the therapy for toxoplasmosis. DNA from the blood of 36 AIDS patients with other neurologic opportunistic infections was used as control group. Sensitivities of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Cerebral toxoplasmosis; Molecular diagnosis; PCR markers.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400006

Molecular diagnosis of cryptococcal meningitis in cerebrospinal ﬂuid: comparison of primer sets for Cryptococcus neoformans and Cryptococcus gattii species complex
Provedor de dados: 55
Autores: Martins,Marilena dos Anjos; Brighente,Kate Bastos Santos; Matos,Terezinha Aparecida de; Vidal,Jose Ernesto; Hipólito,Daise Damaris Carnietto de; Pereira-Chioccola,Vera Lucia.
Aim:This study evaluated the use of polymerase chain reaction for cryptococcal meningitis diagnosis in clinical samples.Materials and methods:The sensitivity and speciﬁcity of the methodology were evaluated using eight Cryptococcus neoformans/C. gattiispecies complex reference strains and 165 cere- brospinal ﬂuid samples from patients with neurological diseases divided into two groups: 96 patients with cryptococcal meningitis and AIDS; and 69 patients with other neurological opportunistic diseases (CRL/AIDS). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a speciﬁc product for C. neoformansand another for C. gattii).Results:CN4-CN5 primer set was positive in all Cryptococcusstandard strains and in 94.8% in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcal meningitis; Acquired immunodeﬁciency syndrome; Polymerase chain reaction; Cerebrospinal ﬂuid.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100062

Molecular diagnosis of symptomatic toxoplasmosis: a 9-year retrospective and prospective study in a referral laboratory in São Paulo, Brazil
Provedor de dados: 55
Autores: Camilo,Lilian Muniz; Pereira-Chioccola,Vera Lucia; Gava,Ricardo; Meira-Strejevitch,Cristina da Silva; Vidal,Jose Ernesto; Mattos,Cinara Cássia Brandão de; Frederico,Fábio Batista; De Mattos,Luiz Carlos; Spegiorin,Lígia Cosentino Junqueira Franco; Murata,Fernando Henrique Antunes; Ferreira,Marina Neves; Barbosa,Deusenia Machado Ulisses; Gonçalves,Fausto da Silva; Dias,Cristiane Moraes; Catelan,Marcia Wakai; Siqueira,Rubens Camargo; Previato,Mariana; Barbosa,Amanda Pires; Cavallini,Danilo.
ABSTRACT Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10-20% of the infected people. Aiming to improve the molecular diagnosis of symptomatic toxoplasmosis in Brazilian patients, this study evaluated the performance of real time PCR testing two primer sets (B1 and REP-529) in detecting Toxoplasma gondii DNA. The methodology was assayed in 807 clinical samples with known clinical diagnosis, ELISA, and conventional PCR results in a 9-year period. All samples were from patients with clinical suspicion of several features of toxoplasmosis. According to the minimum detection limit curve (in CT), REP-529 had greater sensitivity to detect T. gondii DNA than B1. Both primer sets were retrospectively evaluated using 515...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasma gondii; Symptomatic toxoplasmosis; Diagnosis; Real-time polymerase chain reaction.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600638

Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil
Provedor de dados: 55
Autores: Garcia,Rita de Cássia Nasser Cubel; Pereira,Renata Freire Alves; Azevedo,Kátia Martins Lopes de; Castro,Tatiana Xavier de; Mello,Francisco C.A.; Setubal,Sérgio; Siqueira,Marilda M.; Brown,David; Oliveira,Solange Artimos de.
Abstract This study was conducted to provide information on the genetic diversity of human parvovirus B19 (B19V) circulating in the municipality of Niterói, Rio de Janeiro, Southeast Brazil during 1996–2006, a period with two distinct outbreaks of B19V infection: 1999–2000 and 2004–2005. A total of 27 sera from patients with erythema infectiosum and five sera from HIV-infected patients that tested positive for B19V DNA during the study period were analyzed. To genotype B19V strains, a semi-nested PCR for partial amplification of the capsid gene was performed and sequence analysis revealed that 31 sequences belonged to subgenotype 1a (G1a) of the main genotype 1 and one sequence was characterized as subgenotype 3b (G3b). The phylogenetic tree supported the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: B19V genotypes; Outbreak; Erythema infectiosum; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100102

Molecular epidemiology and antimicrobial susceptibility of Enterococci recovered from Brazilian intensive care units
Provedor de dados: 55
Autores: Titze-de-Almeida,Ricardo; Rollo Filho,Maurício; Nogueira,Celeste A.; Rodrigues,Isabela P.; Eudes Filho,João; Nascimento,Rejane S. do; Ferreira II,Renato F.; Moraes,Lídia M. P.; Boelens,Hélène; Van Belkum,Alex; Felipe,Maria Sueli Soares.
We studied the antimicrobial resistance and the molecular epidemiology of 99 enterococcal surveillance isolates from two hospitals of Brasília, Brazil. Conventional biochemical tests were used to identify the enterococcal species and the disk diffusion method was used to determine their resistance profiles. Enterococcus faecalis (76%) and E. faecium (9%) were the most prevalent species. No enterococci showed the vanA or vanB vancomycin resistance phenotypes or genotypes. Only the intrinsically resistant species E. gallinarum (n=2) and E. casseliflavus (n=3) harbored the vancomycin-resistance genes vanC1 and vanC2/3, respectively. We found E. faecalis isolates with high-level resistance to gentamicin (22%) and streptomycin (8%) and both E. faecalis and E....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococci; Antimicrobial resistance; Genotyping.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300002

Molecular epidemiology of Acinetobacter baumannii in central intensive care unit in Kosova teaching hospital
Provedor de dados: 55
Autores: Raka,Lul; Kalenc,Smilja; Bošnjak,Zrinka; Budimir,Ana; Katić,Stjepan; Šijak,Dubravko; Mulliqi-Osmani,Gjyle; Zoutman,Dick; Jaka,Arbëresha.
Infections caused by bacteria of genus Acinetobacter pose a significant health care challenge worldwide. Information on molecular epidemiological investigation of outbreaks caused by Acinetobacter species in Kosova is lacking. The present investigation was carried out to enlight molecular epidemiology of Acinetobacterbaumannii in the Central Intensive Care Unit (CICU) of a University hospital in Kosova using pulse field gel electrophoresis (PFGE). During March - July 2006, A. baumannii was isolated from 30 patients, of whom 22 were infected and 8 were colonised. Twenty patients had ventilator-associated pneumonia, one patient had meningitis, and two had coinfection with bloodstream infection and surgical site infection. The most common diagnoses upon...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genotyping; Acinetobacter baumannii; Kosova; Intensive care unit.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600004

Molecular epidemiology of coagulase-negative bloodstream isolates: detection of Staphylococcus epidermidis ST2, ST7 and linezolid-resistant ST23
Provedor de dados: 55
Autores: Martínez-Meléndez,Adrián; Morfín-Otero,Rayo; Villarreal-Treviño,Licet; Camacho-Ortíz,Adrián; González-González,Gloria; Llaca-Díaz,Jorge; Rodríguez-Noriega,Eduardo; Garza-González,Elvira.
Abstract The mechanisms contributing to persistence of coagulase-negative staphylococci are diverse; to better understanding of their dynamics, the characterization of nosocomial isolates is needed. Our aim was to characterize phenotypic and molecular characteristics of Staphylococcus epidermidis and Staphylococcus haemolyticus human blood isolates from two tertiary care hospitals in Mexico, the Hospital Universitario in Monterrey and the Hospital Civil in Guadalajara. Antimicrobial susceptibility was determined. Biofilm formation was assessed by crystal violet staining. Detection of the ica operon and Staphylococcal Cassette Chromosome mec typing were performed by PCR. Clonal relatedness was determined by Pulsed-fiel gel electrophoresis and Multi locus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Linezolid resistance; Staphylococcal Cassette; Chromosome mec; Coagulase-negative staphylococci; Multilocus Sequence Typing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500419

Molecular epidemiology of CTX-M producing Enterobacteriaceae isolated from bloodstream infections in Rio de Janeiro, Brazil: emergence of CTX-M-15
Provedor de dados: 55
Autores: Seki,Liliane Miyuki; Pereira,Polyana Silva; Conceição,Magda de Souza; Souza,Maria José; Marques,Elizabeth Andrade; Carballido,Jupira Miron; Carvalho,Maria Elisabeth Serqueira de; Assef,Ana Paula D'Alincourt Carvalho; Asensi,Marise Dutra.
OBJECTIVE: The present studywas designed to evaluate the molecular epidemiology of CTX-M producing Klebsiella pneumoniae, Enterobacter cloacae and Escherichia coli isolated from bloodstream infections at tertiary care hospitals in the State of Rio de Janeiro, Brazil. MATERIAL AND METHODS: A total of 231 nonduplicate Enterobacteriaceae were isolated from five Brazilian hospitals between September 2007 and September 2008. The antimicrobial susceptibility testing was performed by disk diffusion method according to the Clinical Laboratory Standard Institute. Isolates showing resistance to third-generation cephalosporins were screened for ESBL activity by the double-disk synergy test. The presence of blaCTX-M , blaCTX-M-15 and blaKPC genes was determined by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bloodstream infections; Enterobacteriaceae; CTX-M-15; PFGE; KPC; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600003

Molecular epidemiology of heteroresistant vancomycin-intermediate Staphylococcus aureus in Brazil
Provedor de dados: 55
Autores: Silveira,Alessandro Conrado de Oliveira; Cunha,Gabriela Rosa da; Caierão,Juliana; Cordova,Caio Mauricio Mendes de; d'Azevedo,Pedro Alves.
ABSTRACTTo determine the epidemiological and molecular characteristics of 12 Staphylococcus aureus isolates presenting heteroresistance to vancomycin in laboratories of two cities in Santa Catarina, southern Brazil. Epidemiological data, including the city of isolation, health institution, and date of isolation were considered, as well as the associated clinical specimen. For molecular characterization, we analyzed the staphylococcal cassette chromosome types, the erm gene presence, and the genomic diversity of isolates using pulsed-field gel electrophoresis. The 12 isolates of S. aureus were previously confirmed as heteroresistance to vancomycin using the population analysis profile-area under curve. Regarding genetic variability, two clones were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Small colony variants; Antimicrobial resistance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500466

Molecular epidemiology of measles virus infection in Shanghai in 2000–2012: the first appearance of genotype D8
Provedor de dados: 55
Autores: Li,Shuhua; Qian,Xiaohua; Yuan,Zhengan; Sun,Xiaodong; Li,Chongshan; Tang,Xian; Yang,Yanji; Gong,Xiangzhen; Cao,Guangwen.
Purpose:The purpose of this study was to identify measles virus in Shanghai in 2012 and study the genotype trend of measles virus epidemic strains during 2000–2012.Methods:Nose and throat swab specimens were collected from 34 suspected measles cases in Shanghai. Measles virus was isolated using Vero-SLAM cells (African green monkey kidney cells/lymphoid signal activating factor-transfected African green monkey kidney cells). The 450 bp of C terminus of the N gene and the entire hemagglutinin gene sequence was amplified using RT-PCR. Phylogenetic analysis was performed by comparing the seven measles strains in Shanghai with the reference strains for H1a, H1b and D8 genotypes, as well as the Chinese measles virus vaccine strain.Results:Seven measles viruses...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: D8 genotype; Importation; Measles virus; Molecular epidemiologya.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600581

Molecular epidemiology of Pseudomonas aeruginosa clinical isolates
Provedor de dados: 55
Autores: Berber,Ismet; Avsar,Cumhur; Yegin,Zeynep; Tekerci,Melike; Civek,Seyhan.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200224

Molecular genotyping and epidemiology of Mycobacterium tuberculosis isolates obtained from inmates of correctional institutions of Campinas, Southeast Brazil
Provedor de dados: 55
Autores: Moreira-Oliveira,M.S.; Oliveira,H.B.; Pace,F.; Stehling,E.G.; Rocha,M.M.M.; Aily,D.C.G.; Brocchi,M.; Silveira,W.D.
The objective of this study was to investigate the possible transmission of tuberculosis among 39 inmates with positive Mycobacterium tuberculosis smears in four correctional institutions located in Campinas City, SP, Brazil over a 19-month period. Fifty-one M. tuberculosis isolates from these inmates were characterized according to the number of IS6110 insertion elements present in their genomic DNA. The number of insertion elements in M. tuberculosis isolates varied from two to twelve. The dendrogram of similarity resulted in the grouping the isolates in six main clusters. These results, associated to epidemiological data, suggested the transmission of tuberculosis among inmates of the same and different institutions inmates. Univariate analysis of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Transmission; Molecular genotyping; Campinas; SP; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600009

Molecular identification and antimicrobial susceptibility of Staphylococcus aureus nasal isolates from medical students in Cartagena, Colombia
Provedor de dados: 55
Autores: Bettin,Alfonso; Causil,Ceyla; Reyes,Niradiz.
Staphylococcus aureus (SA) remains a major cause of nosocomial and community-acquired infections worldwide. Nasal carriage of this bacterium among hospital personnel constitutes an important source for nosocomial infections. A cross-sectional study enrolling the whole medical student population (n = 387) of the School of Medicine at the Universidad de Cartagena, Colombia, was conducted to evaluate the carriage rates of both methicillin sensitive-and methicillin resistant-SA, the frequency of Panton-Valentine leukocidin genes in the isolates, and risk factors associated with carriage in this selected population. After signing an informed consent, participants completed a survey related to possible risk factors for colonization, and nasal swabs were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carrier state; Staphylococcus aureus; Methicillin resistance; Panton-Valentine leukocidin.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400003

Molecular identification and typing of Mycobacterium massiliense isolated from postsurgical infections in Brazil
Provedor de dados: 55
Autores: Monego,Fernanda; Duarte,Rafael Silva; Nakatani,Sueli Massumi; Araújo,Wildo Navegantes; Riediger,Irina Nastassja; Brockelt,Sonia; Souza,Verena; Cataldo,Jamyra Iglesias; Dias,Rubens Clayton da Silva; Biondo,Alexander Welker.
OBJECTIVE: One hundred thirty-one cases of postsurgical infections were reported in Southern Region of Brazil between August 2007 and January 2008. Thirty-nine (29.8%) cases were studied; this report describes epidemiological findings, species identification, antimicrobial susceptibility and clonal diversity of rapidly growing mycobacteria isolated in this outbreak. METHODS: All 39 isolates were analyzed by Ziehl-Nielsen stained smear, bacterial culture and submitted to rpoB partial gene sequencing for identification. The isolates were also evaluated for their susceptibility to amikacin, cefoxitin, clarithromycin, ciprofloxacin, doxycycline, tobramycin and sulfamethoxazole. RESULTS: Thirty-six isolates out of the confirmed cases were identified as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacteria; Atypical mycobacterium infections microbiological analysis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500004

Molecular identification of viral agents associated with acute conjunctivitis: a prospective controlled study
Provedor de dados: 55
Autores: Akçay,Emine; Çarhan,Ahmet; Hondur,Gözde; Tufan,Zeliha Koçak; Duru,Necati; Kılıç,Selçuk; Ensari,Ezgi Naz; Uğurlu,Nagihan; Çağıl,Nurullah.
Abstract  Background: Viral conjunctivitis are the most frequent infections in ophthalmology clinics. The diagnosis is usually relying on clinical findings and medical history. However, topical antibiotics are often used unnecessarily addition to symptomatic treatment because of unsure agents. We aimed to detect the Adenovirus, Coxsackievirus and Enterovirus from conjunctiva and pharyngeal samples of patients.  Methods: The conjunctiva and pharyngeal samples of the patients with conjunctivitis were taken by Virocult transport media and kept at -80 ºC up to study day. Adenovirus spp, Enterovirus 70 and Enterovirus 71, Coxsackie A24 and Coxsackie A16 were detected by real-time PCR. Samples from healthy health care workers of ophthalmology clinic were used...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adenovirus; Conjunctivitis; Viral; PCR.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400391

Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
Provedor de dados: 55
Autores: Dizbay,Murat; Kalkanci,Ayse; Sezer,Busra Ergut; Aktas,Firdevs; Aydogan,Sibel; Fidan,Isil; Kustimur,Semra; Sugita,Takashi.
We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidemia; Candida parapsilosis; Nosocomial outbreak; Intensive care unit; RAPD; DNA sequencing.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500010

Molecular techniques for MRSA typing: current issues and perspectives
Provedor de dados: 55
Autores: Trindade,P. A.; McCulloch,J. A.; Oliveira,G. A.; Mamizuka,E. M.
Staphylococcus aureus has long been recognised as an important pathogen in human disease. Serious staphylococcal infections can frequently occur in inpatients and may lead to dire consequences, especially as to therapy with antimicrobial agents. The increase in the frequency of Methicillin-Resistant Staphylococcus aureus (MRSA) as the causal agent of nosocomial infection and the possibility of emergence of resistance to vancomycin demands a quick and trustworthy characterization of isolates and identification of clonal spread within hospitals. Enough information must be generated to permit the implementation of appropriate measures for control of infection, so that outbreaks can be contained. Molecular typing techniques reviewed in this manuscript include:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Molecular epidemiology; Genotyping; Methicillin resistance.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100005

Molecular types of Cryptococcus species isolated from patients with cryptococcal meningitis in a Brazilian tertiary care hospital
Provedor de dados: 55
Autores: Wirth,Fernanda; Azevedo,Maria Isabel; Goldani,Luciano Z.
ABSTRACT There are limited data on the molecular epidemiology of cryptococcosis in Brazil. Here, we report on the identification of the molecular pattern of the Cryptococcus species that caused meningitis in patients admitted in a Brazilian reference tertiary care hospital, and review the published studies addressing the molecular epidemiology of Cryptococcus in Brazil. Our study has shown the predominance of molecular type VNII in HIV-infected patients with cryptococcal meningoencephalitis. Molecular types VNII and VGII were occasionally detected in HIV-infected and non-infected patients with meningoencephalitis. In contrast, previous studies have shown that several regions exhibited a high prevalence of the VNI molecular type and sporadic cases of the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cryptococcus; Genotypes; Molecular types; Epidemiology; Brazil.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600495

Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil
Provedor de dados: 55
Autores: Stehling,Eliana Guedes; Leite,Domingos S; Silveira,Wanderley D.
The present study had as objective to evaluate the genotypic diversity and biological characteristics, such as hemolysin, protease, elastase of 56 clinical strains of Pseudomonas aeruginosa isolated from 13 cystic fibrosis (CF) patients attending at the School Hospital of Campinas State University (UNICAMP), Brazil. Genotypic diversity has been determined by Ribotyping (RT) and the pattern of the enterobacterial repetitive intergenic consensus PCR (ERIC-PCR) of each strain. The production of elastase was significantly different only among mucoid and nonmucoid isolates. Joint results obtained by (RT) and ERIC-PCR methods were able to discriminate all strains isolated from both the same and different patients. Additionally, we observed four strain clusters...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cystic fibrosis; Pseudomonas aeruginosa; Clonal analysis; Biological characteristics.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500007

Molecular typing of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in two metropolitan areas of São Paulo State, southeast Brazil
Provedor de dados: 55
Autores: Cury,Gisele Gentile; Mobilon,Cristiane; Stehling,Eliana Guedes; Lancellotti,Marcelo; Ramos,Marcelo de Carvalho; Martinez,Roberto; Brocchi,Marcelo; Silveira,Wanderley Dias da.
One hundred and fifty-one methicillin-resistant z (MRSA) strains have been isolated from patients admitted in tertiary care hospitals in two metropolitan areas (Campinas City and Ribeirão Preto City) in the southeast region of Brazil and analyzed through PCR-based techniques [(PCR amplification of spa, coa, and housekeeping genes (arcC, aroE, gmk, pta, tpi, yqiL)] and further restriction fragment typing of coa and of housekeeping genes. The heterogeneity of spa gene was determined directly by agarose gel electrophoresis migration. The results obtained indicate the existence of three (A, B, C) main clusters. Since the strain distribution in these three clusters is much characteristic, it denotes the existence of three main clones. All strains isolated in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Nosocomial; Molecular characterization; PCR.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300002

Monetary costs and hospital burden associated with the management of invasive fungal infections in Mexico: a multicenter study
Provedor de dados: 55
Autores: Corzo-León,Dora Edith; Perales-Martínez,Diana; Martin-Onraet,Alexandra; Rivera-Martínez,Norma; Camacho-Ortiz,Adrian; Villanueva-Lozano,Hiram.
ABSTRACT  Background: Invasive fungal infections (IFIs) affect &gt;1.5 million people per year. Nevertheless, IFIs are usually neglected and underdiagnosed. IFIs should be considered as a public-health problem and major actions should be taken to tackle them and their associated costs. Aim To report the incidence of IFIs in four Mexican hospitals, to describe the economic cost associated with IFIs therapy and the impact of adverse events such as acute kidney injury (AKI), liver damage (LD), and ICU stay.  Methods: This was a retrospective, transversal study carried-out in four Mexican hospitals. All IFIs occurring during 2016 were included. Incidence rates and estimation of antifungal therapy's expenditure for one year were calculated. Adjustments for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fungal infections; Antifungal therapy; Cost; Acute kidney injury; Incidence rate; Mexico.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500360

Monitoring the emergence of HBV resistance mutations by HBV-RNA pyrosequencing
Provedor de dados: 55
Autores: Bottecchia,Marcelle; Barcaiu,Halime Silva; Lewis-Ximenez,Lia Laura; da Silva e Mouta Junior,Sergio; de Moraes,Marcia Terezinha Baroni.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200216

Monoclonal gammopathy associated with visceral leishmaniasis
Provedor de dados: 55
Autores: Sharma,Vishal; Agarwal,Mukul P; Giri,Subhash.
Monoclonal gammopathy can accompany diverse conditions and is usually benign. It should be distinguished from monoclonal gammopathy of undetermined significance (MGUS) which can rarely turn malignant. Visceral leishmaniasis has only rarely been associated with monoclonal gammopathy. We describe the case of a 55-year-old male who had monoclonal gammopathy associated with visceral leishmanisais, which reversed with stibogluconate therapy.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Visceral leishmaniasis; Monoclonal gammopathy.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300018

Monocular blindness in a non-ketotic patient
Provedor de dados: 55
Autores: Bhatt,Archit; Bhavsar,Bhavini; Farooq,Muhammad U.; Dahdouh,Michelle.
Tipo: Info:eu-repo/semantics/article
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200014

Morbimortality study of infection in patients undergoing different types of dialysis in a renal replacement therapy center
Provedor de dados: 55
Autores: Curty,Natália Fabiane Ridão; Martins,Lucilene Fagundes da Silva; Ito,Carmen Antônia Sanches; Schafranski,Marcelo; Brites,Dorelayne Aparecida; Busato,César Roberto.
INTRODUCTION: Renal replacement therapy is the treatment of end-stage chronic kidney disease and can be performed through dialysis catheters, arteriovenous fistulas/grafts, and peritoneal dialysis. Patients are usually immunocompromised and exposed to invasive procedures, leading to high rates of infection and increased mortality.OBJECTIVES: To compare the prevalence of infection and related deaths, as well as the sensitivity profile of the putative bacteria in patients treated with peritoneal dialysis, arteriovenous fistula hemodialysis and catheter hemodialysis.METHODS: This is case-control study. Six hundred forty-four patients undergoing renal replacement therapy were selected. Patients were divided into three groups according to the modality of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hospital infection; Morbimortality; Renal replacement therapy center; Hemodialysis; Bacteria; Sensitivity profiles.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300281

More about human monocytotropic ehrlichiosis in Brazil: serological evidence of nine new cases
Provedor de dados: 55
Autores: Costa,Paulo Sérgio Gonçalves da; Valle,Lena Márcia de Carvalho; Brigatte,Marco Emilio; Greco,Dirceu Bartolomeu.
Human Ehrlichia chaffeensis infections have been reported in North America, Asia and Europe, but only recently have human cases been reported in Brazil. Nine new human cases of E. chaffeensis infection diagnosed on a clinical and serological basis are reported. Serological tests were performed with indoor slides prepared with CDC stock DH-82 cells infected with E. chaffeensis (Arkansas strain). All but two patients were adults. Seven patients were male and two female. The fever duration varied from 4 to 120 days with a median of 6 days. All patients recalled previous tick attack. IgM was detected in four cases. Influenza like syndrome was the most frequent clinical form affecting five patients. Two patients had fever of unknown origin (FUO), one patient...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Monocytotropic ehrlichiosis; Brazil; Humans.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100002

Mortality of children following a diagnosis of HIV infection in northeastern Brazil
Provedor de dados: 55
Autores: de Lemos,Lígia Mara Dolce; Anglemyer,Andrew; Lippi,Joseph David; Rutherford,George Willams; Santos,Victor Santana; Rocha,Thaisa Fonseca Siqueira; da Conceição,Marcus Vinícius; Gurgel,Ricardo Queiroz.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100104

Mortality rate in patients with nosocomial Acinetobacter meningitis from a Brazilian hospital
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Penteado-Filho,Sergio R; Amarante,Diogo; Andrade,Marcio A; Borba,Luis A.
BACKGROUND: The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. OBJECTIVE: The aim of this study was to evaluate the factors that have influence over the outcomes in ANM patients. METHODS: A retrospective analysis of 22 cases of ANM was conducted in a hospital with high incidence of multidrug resistance. RESULTS: The mean age of patients was 43 years (21 to 91) and 54.5% were male. All ANM cases occurred within 60 days of admission and the mean duration of illness was of 18.2 days. All cases were associated with previous neurosurgical procedures: elective surgery (27.2%), external shunt (54.4%) and emergency surgery due to trauma (18.1%). Imipenem resistance was observed in 40.9% of cases, but ampicillin/sulbactam...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter; Meningitis; Acinetobacter baumannii; Neurosurgery; Imipenem; Ampicillin/sulbactam.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500003

MRSA from Santa Catarina State, Southern Brazil: intriguing epidemiological differences compared to other Brazilian regions
Provedor de dados: 55
Autores: Silveira,Alessandro C.O.; Cunha,Gabriela R.; Caierão,Juliana; Cordova,Caio M. de; d'Azevedo,Pedro A.
Methicillin-resistant Staphylococcus aureus(MRSA) is one of the most frequently isolated agents in both nosocomial and community settings. It is a constant challenge for antibacterial therapy. Therefore, it becomes essential to understand the epidemiology of MRSA isolates in the institution and/or region to guide empirical therapy. The objective of this study was to evaluate the epidemiological characteristics of MRSA isolates in the state of Santa Catarina, Brazil, and determine if there is a clonal spread. We evaluated 124 clinical isolates of MRSA obtained from various anatomical sites from patients in the state of Santa Catarina in Southern Brazil. The antimicrobial susceptibility proﬁle was evaluated by disk diffusion and minimum inhibitory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimicrobial resistance; Vancomycin; Oxacillin.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400384

MRSA outbreak at a transplantation unit
Provedor de dados: 55
Autores: Romanelli,RMC; Clemente,WT; Lima,SSS; Rezende,EM; Martinho,GH; Paiva,LFR; Neves,FAC; Madeira,JGC; Amâncio,GCS; Lima,AS; Faria,LC; Coutinho,RL.
Methicillin-resistant Staphylococcus aureus (MRSA) infections frequently complicate the post-operative course of transplant recipients, and despite nasal carriage and endemic colonization, MRSA outbreaks are not commonly described. This study reports a case of MRSA outbreak and discusses infection control measures and recommendations for this situation.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Outbreak; Surgical site infection; Liver transplantation; RAPD.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100011

Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox® Antimicrobial Potency Study in Latin America (LA-ZAPS)
Provedor de dados: 55
Autores: Ballow,Charles H.; Biedenbach,Douglas J.; Rossi,Flavia; Jones,Ronald N.
Linezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to other antimicrobial classes. We conducted a multicenter surveillance (Zyvox Antimicrobial Potency Study; ZAPS) trial of qualifying Gram-positive isolates from 24 medical centers in eight countries in Latin America. The activity and spectrum of linezolid was compared to numerous agents including glycopeptides, quinupristin/dalfopristin, b-lactams and fluoroquinolones when testing 2,640 strains by the standardized disk diffusion method or Etest (AB BIODISK, Solna, Sweden). The linezolid spectrum was complete...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Linezolid; Oxazolidinones; Antimicrobial surveillance; Resistant Gram-positive cocci; ZAPS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300001

Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program
Provedor de dados: 55
Autores: Oplustil,Carmen Paz; Nunes,Rogério; Mendes,Caio.
Surveillance programs are essential to detect the increase of antimicrobial resistance, and several different programs are being conducted in many countries. The RESISTNET is a surveillance program for bacterial resistance against several antimicrobial agents initiated in 1998 among Latin American countries. In Brazil, several centers were invited to join this surveillance and a total of 11 centers (6 from São Paulo and 5 from other states) participated in the study. All results were analyzed using the WHONET program. A total of 894 Escherichia coli, 386 Klebsiella pneumoniae, 70 Shigella spp and 57 Salmonella spp strains were analyzed in this study from April, 1998, to April, 1999. Susceptibility testing was performed by the disk diffusion method using...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterobacteria; Antimicrobial resistance; Surveillance programs; WHONET.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100002

Multidrug resistant Salmonella typhi and antimicrobial agent quality and bioavailability
Provedor de dados: 55
Autores: Arya,Subhash C.; Agarwa,Nirmala.
Tipo: Info:eu-repo/semantics/other
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600001

Multidrug resistant tuberculosis versus non-tuberculous mycobacterial infections: a CT-scan challenge
Provedor de dados: 55
Autores: Kahkouee,Shahram; Esmi,Elham; Moghadam,Azadeh; Karam,Mehrdad Bakhshayesh; Mosadegh,Leila; Salek,Solmaz; Tabarsi,Payam.
INTRODUCTION: Clinical, laboratory and imaging findings in patients with multidrug resistanttuberculosis (MDR-TB) and non-tuberculosis mycobacterium (NTM) are similar, and the majority of these patients present with positive smear for Acid Fast Bacilli (ADB) and no response to first line anti-TB treatment, so sputum culture and PCR are necessary, especially in NTM. OBJECTIVE: In this study we evaluate more details of imaging findings to help earlier diagnosis of pathogens. MATERIALS AND METHODS: 66 patients with positive smear for AFB and no response to first line anti-TB drugs were divided into two groups by PCR and culture: MDR-TB (43 patients) and NTM (23 patients). Age, sex, history of anti-TB treatment, smoking and CT-scan findings (parenchymal,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MDR-TB; NTM; Tuberculosis.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200004

Multidrug-resistant Acinetobacter baumannii clones persist on hospital inanimate surfaces
Provedor de dados: 55
Autores: Rocha,Igor Vasconcelos; Xavier,Danilo Elias; Almeida,Karoline Rissele Henrique de; Oliveira,Sibele Ribeiro de; Leal,Nilma Cintra.
ABSTRACT Acinetobacter baumannii is one of the most frequent Gram-negative opportunistic pathogens associated with hospital-acquired infection worldwide. We briefly describe A. baumannii isolates that were recovered from surrounding ICU bed surfaces, exhibiting multidrug resistance phenotype and belonging to some widely spread clonal complexes of clinical A. baumannii isolates.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Acinetobacter baumannii; Hospital environment; ICU surface.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500438

Multidrug-resistant bacteria isolated from intensive-care-unit patient samples
Provedor de dados: 55
Autores: Japoni,Aziz; Vazin,Afsaneh; Hamedi,Mahdi; Davarpanah,Mohammad Ali; Alborzi,Abdolvahab; Rafaatpour,Noraladin.
We examined epidemiological aspects and bacterial resistance patterns of bacteria isolated from intensive care unit (ICU) patient samples. During a 10 month period (from June 2006 to March 2007), 812 samples of blood, urine and cerebral spinal fluid (CSF) from 553 hospitalized patients, in ICU wards, including pediatric surgical, neonatal, adult surgical I, adult surgical II, general pediatrics, neurosurgical I, neurosurgical II, and internal medical, were collected. Minimum inhibitory concentration (MIC) of antibiotics for bacteria isolates was determined by the E-test method. The internal medicine ICU with 28.7% admissions gave the largest contribution. Coagulase negative staphylococci at frequencies of 66.7 % and 36.5 % and E. coli at 20.9% were the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intensive care unit; Minimum inhibitory concentration; Multidrug-resistant bacteria.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200009

Multidrug-resistant tuberculosis
Provedor de dados: 55
Autores: Lemos,Antônio Carlos Moreira; Matos,Eliana Dias.
Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although in 2008 only 7% of these (29,423 cases) were notified. The laboratory tests for diagnosing resistance may be phenotypic (based on culture growth in the presence of drugs) or genotypic (i.e. identification of the presence of mutations that confer resistance). The urgent need for a rapid means of detecting resistance to anti-TB drugs has resulted in the development of many genotypic methods over recent years. The treatment of MDR-TB is expensive, complex, prolonged (18-24 months) and associated with a higher...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multidrug-resistant tuberculosis; Review; Diagnosis; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200018

Multidrug-resistant tuberculosis: case reports study in a central state of Brazil
Provedor de dados: 55
Autores: Araújo-Filho,João Alves de; Vasconcelos-Jr,Arioldo Carvalho; Sousa,Eduardo Martins de; Silveira,Colombina da; Sousa,Patrícia Tavares Pereira de; Severo,Klaus Andrade; Vieira,Ludmila Ferreira; Kipnis,André; Junqueira-Kipnis,Ana Paula.
Multidrug-resistant tuberculosis (MDR-TB) is an emerging and worrisome health problem that threatens tuberculosis (TB) control worldwide. The clinical management of MDR-TB is a complex issue associated with the use of multiple drugs for a long period, usually accompanied by side effects and high costs. The objective of this work was to relate cases of MDR-TB occurring in Goiás, a central state of Brazil. We related five cases of MDR-TB, three women and two men. All were pulmonary cases. Three were in their second treatment and two in their first treatment. Surgical pulmonary resection was performed in one case. One death occurred. Lack of adherence, gastric intolerance to anti-TB drugs and poor clinical management were the main aspects related to the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; Multidrug-resistant tuberculosis; MDR-TB; Mycobacterium tuberculosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100020

Multidrug-resistant urinary tract isolates of escherichia coli from Ribeirão Preto, São Paulo, Brazil
Provedor de dados: 55
Autores: Santo,Edilene; Salvador,Miriam Mendonça; Marin,José Moacir.
Multiple resistances to antimicrobial drugs arising in Escherichia coli isolates may complicate therapeutic management of urinary tract infection (UTI) by this organism. In order to assess the multidrug resistance (MDR) among urinary E. coli isolates, we have tested 11 antimicrobial drugs against 67 isolates from outpatients attended in a tertiary-care teaching hospital and of 78 isolates from a municipal health unit, respectively in Ribeirão Preto, State of São Paulo, Brazil. Seventy-six percent and 22% of the isolates from the tertiary-care hospital and the municipal unit, respectively, were resistant to three or more different classes of agents, and were considered to present MDR. Among the isolates from the hospital patients, 73.0%, 65.0%, 58.0%, 58.0%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urinary tract infections; Escherichia coli; Antimicrobial susceptibility; Multidrug-resistance.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600010

Multiorgan involvement due to cytomegalovirus infection in AIDS
Provedor de dados: 55
Autores: Majumder,Shounak; Mandal,Sanjay K.; Bandyopadhyay,Dipanjan; Chowdhury,Subhasis Roy; Chakraborty,Partha P.; K.,Mitra.
Cytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower limb weakness and symptomatic pallor. He was already on antiretroviral drugs for a month prior to presentation. Detailed clinical examination and laboratory investigations revealed cytomegalovirus polyradiculoneuropathy associated with bone marrow dysplasia. Dysplasia of haematopoeitic cell lines occurs in 30% to 70% of HIV infected patients, and is often indistinguishable from myelodysplastic syndrome. However, in our case, the bone marrow picture reverted back to...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; Cytomegalovirus; Multiorgan involvement.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100039

Multiple cutaneous swellings in an immunocompetent host: cryptococcosis overlooked
Provedor de dados: 55
Autores: Kosaraju,Kranthi; Mukhopadhyay,Chiranjoy; KE,Vandana; Yagain,Kiran; NR,Rao.
Recently, there has been an increase in the incidence of cryptococcosis even among immunocompetent patients. We present a case of multiple subcutaneous swellings later developing into a non-healing ulcer caused by Cryptococcus in a 60 year-old immunocompetent male along with a brief review of clinical presentations of cutaneous cryptococcosis in immunocompetent and immunocompromised individuals. A high index of suspicion is desired in view of possible dissemination and variable non-specific clinical presentations.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcosis; Cryptococcus neoformans; Skin ulcer.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400017

Multiple organ failure in septic patients
Provedor de dados: 55
Autores: Bilevicius,Elizabeth; Dragosavac,Desanka; Dragosavac,Sanja; Araújo,Sebastião; Falcão,Antonio L.E.; Terzi,Renato G.G.
Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. It is strongly related to number of systems with failure, type of system involved, risk factors such as age, previous chronic diseases, delayed or inadequate resuscitation, persistent infection, immune suppression, and others. The prognoses is worse for patients rather than in elective or emergency surgical patients. The objective of this article is to provide data from our university teaching hospital ICU related to the incidence of septic patients, the distribution of MOF, and distribution of failure among each of the organs. The mortality rate, relationship between mortality and age, and mortality and types of organs affected were evaluated. The main...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: APACHE II; Sepsis; Multiple organ failure.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300001

Multiple types of human papillomavirus in cervical samples in women in Campo Grande, MS, Brazil
Provedor de dados: 55
Autores: Tozetti,Inês Aparecida; Scapulatempo,Ilzia Doraci Lins; Kawski,Vicky Liege; Ferreira,Antonio Walter; Levi,José Eduardo.
We analyzed 87 cervical samples from Campo Grande, Mato Grosso do Sul, with a PGMY/GP+ nested PCR system. Positive samples were typed using E7 type-specific primer pairs for HPV 6/11, 16, 18, 45 and 66. Eighteen samples (22%) were infected with HPV6/11, 18 samples (22%) with HPV66, 13 samples (15.9%) with HPV45, 8 samples (9.8%) with HPV18 and 7 samples (8.5%) with HPV16. Seventeen samples (20.7%) were infected by two HPV types, and five samples (6.1%) by three HPV types. We conclude that infection with multiple types is present at a high frequency in our population and that there is a relation between some types and cytological finds.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human papillomavirus; Multiple types; Nested PCR; TS-PCR.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500001

Multivariate analysis of the factors associated with the risk of pneumonia in intensive care units
Provedor de dados: 55
Autores: Carrilho,Cláudia Maria Dantas de Maio; Grion,Cintia Magalhães Carvalho; Bonametti,Ana Maria; Medeiros,Eduardo Alexandrino Servolo; Matsuo,Tiemi.
Pneumonia is the most frequent hospital infection in patients admitted to intensive care units (ICU) and is also responsible for the highest lethality rates, as well as an increase in both the duration and costs of hospitalization. The objective of this study was to identify predisposing factors for pneumonia. A prospective cohort study was carried out between June 1996 and June 1997, and included 540 patients admitted consecutively for periods greater than 24 hours to the adult ICU of the Londrina State University's Teaching Hospital. Of these, 83 (15.4%) developed pneumonia. All patients were analyzed with respect to various risk factors for hospital-acquired pneumonia. Univariate analysis identified the following factors: decreased level of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Epidemiology; Risk factors.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300008

Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Provedor de dados: 55
Autores: Ding,Feng; Miao,Xi-Li; Li,Yan-Xia; Dai,Jin-Fen; Yu,Hong-Gang.
Abstract  Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown.  Aims This research aimed to determine the clinical and virological features of the rare pattern.  Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included: 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences.  Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Coexistence of HBsAg and anti-HBs; S gene; Reverse transcriptase.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100001

Mycobacterial spindle cell pseudotumor of the appendix vermiformis in a patient with AIDS
Provedor de dados: 55
Autores: Basílio-de-Oliveira,Carlos Alberto; Eyer-Silva,Walter A.; Valle,Heliomar de Azevedo; Rodrigues,Ana Lúcia; Pimentel,Ana Luisa Pinheiro; Morais-de-Sá,Carlos Alberto.
Mycobacterial pseudotumor (MP) is a rare pathologic presentation of both Mycobacterium tuberculosis and non-tuberculous mycobacterial disease, hitherto reported to occur only in immunosuppressed patients with or without human immunodeficiency virus infection. This lesion shares close pathologic resemblance to certain mesenchymal neoplasms, particularly Kaposi's sarcoma (KS), from which it must be properly differentiated due to distinct prognosis and therapy. We report a case of MP obliterating the lumen of the appendix vermiformis in a 34-year-old patient who died of complications of AIDS at our hospital in Rio de Janeiro. A total of 24 cases of MP (including our patient) have been described in the literature. MP has been found especially in lymph nodes,...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV infection; Kaposi's sarcoma; Mycobacterium; Pseudotumor; Spindle cell.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200008

Mycobacterium aurum keratitis: an unusual etiology of a sight-threatening infection
Provedor de dados: 55
Autores: Honarvar,Behnam; Movahedan,Hossein; Mahmoodi,Mojtaba; Sheikholeslami,Fatemeh Maryam; Farnia,Parisa.
Atypical fast-growing Mycobacterium species are usually identified after laser-assisted in situ keratomileusis, cosmetic surgeries, and catheter-related, pulmonary or soft tissue infections. We herein present the case of a 56-year-old man with purulent discharge, redness, and foreign body sensation in his left eye. He underwent two surgeries that partially controlled the infection but were not curative. Corneal transplantation was performed, and a biopsy of the excised cornea indicated Mycobacterium aurum infection, which was confirmed by polymerase chain reaction-restriction fragment length polymorphism analysis. This appears to be the first documented case of keratitis attributable to the non-tuberculous mycobateria M. aurum. The intractable extra-ocular...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mycobacteria; Atypical Keratitis Corneal transplantation.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200019

Mycobacterium avium-intracellulare and the unpredictable course of hypercalcemia in an AIDS patient
Provedor de dados: 55
Autores: Ayoubieh,Houriya; Alkhalili,Eyas.
Abstract A 37-year-old man with AIDS presented with altered mental status four weeks after stopping his medications for Mycobacterium avium-intracellulare (MAI). He had low CD4 cell count and severe hypercalcemia. Bone marrow biopsy revealed bone marrow infiltration by granulomas positive for acid-fast bacilli and cultures grew MAI. His hypercalcemia continued to worsen with the initiation of MAI therapy but we were able to treat it successfully with pamidronate and calcitonin.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hypercalcemia; AIDS; Mycobacterium infection.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100116

Mycobacterium neoaurum causing prosthetic valve endocarditis: a case report and review of the literature
Provedor de dados: 55
Autores: Kumar,Anupam; Pazhayattil,George S.; Das,Aparna; Conte,Harry A.
Mycobacterium neoaurum is a rare cause of bacteremia, and infection usually occurs in an immunocompromised host in the setting of an indwelling catheter. Prosthetic valve endocarditis due to non-tuberculous mycobacteria typically carries a dismal prognosis; we report a case ofM. neoaurum prosthetic valve endocarditis with favorable response to antimicrobial therapy without surgical intervention.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mycobacterium neoaurum; Prosthetic valve; Endocarditis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200235

Mycobacterium simiae infection in a patient with Acquired Immunodeficiency Syndrome
Provedor de dados: 55
Autores: Sampaio,J.L.M.; Artiles,N.; Pereira,R.M.G.; Souza,J.R.; Leite,J.P.G.
Mycobacterium simiae is usually an environmental contaminant rarely associated with human disease. We report a fatal case of M.simiae infection in a 37 year old, HIV positive, male from whom the organism was isolated from blood culture. The identification of M.simiae was performed using DNA amplification followed by analysis on 3% agarose gel of the amplicon fragments after digestion by restriction endonucleases. The precise identification of mycobacterial isolates to the species level is important, with both epidemiological and therapeutic implications.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium simiae; AIDS; RFLP.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600010

Mycobacterium tuberculosis bacteremia diagnosed in an HIV-negative patient in Brazil: a rare or an under-reported event?
Provedor de dados: 55
Autores: Hadad,D. J.; Pignatari,A.C.C.; Machado,M.A.O.; Telles,M.A.S.
A case of Mycobacterium tuberculosis bacteremia in an HIV negative immunodepressed patient was described using the BACTEC 460 TB system. This bacterium should be investigated in the blood of immunodepressed non-HIV infected patients with prolonged fever.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mycobacterium tuberculosis; Mycobacteremia; Immunodeficiency.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200010

Mycobacterium tuberculosis complex bacteremia among HIV and non-HIV patients in a Mexican tertiary care center
Provedor de dados: 55
Autores: Tamez-Torres,Karla Maria; Torres-Gonzalez,Pedro; Cervera-Hernandez,Miguel E.; Chavez-Mazari,Barbara; Barrientos-Flores,Corazon de Jesus; Bobadilla-del-Valle,Miriam; Ponce-de-Leon,Alfredo; Sifuentes-Osornio,Jose.
ABSTRACT  Objectives: To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture.  Methods: Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015.  Results: We reviewed medical records of 533 patients with culture-proven tuberculosis, of whom 27.2% (145/533) had blood culture available. Patients with mycobacteremia presented more frequently with abdominal tuberculosis, body mass index &lt;18 kg/m2, and had lower hemoglobin and albumin levels. No differences were observed regarding HIV status.  Conclusions: Few studies have reported on the characteristics associated with Mycobacterium tuberculosis complex bacteremia, especially among Human Immunodeficiency Virus-negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; Human immunodeficiency virus; Bloodstream infection; Mycobacteremia; Case-control study.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500387

Mycobacterium tuberculosis meningitis as the first presentation of chronic granulomatous disease
Provedor de dados: 55
Autores: Khotaei,Ghamartaj; Hirbod-Mobarakeh,Armin; Amirkashani,Davood; Manafi,Farzad; Rezaei,Nima.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500018

Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review
Provedor de dados: 55
Autores: Khan,Fahmi Yousef; A.yassin,Mohamed.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100018

Mycoplasmateceae species are not found in Fallopian tubes of women with tubo-peritoneal infertility
Provedor de dados: 55
Autores: Costoya,Alberto; Morales,Francisco; Borda,Paula; Vargas,Renato; Fuhrer,Juan; Salgado,Nicole; Cárdenas,Hugo; Velasquez,Luis.
BACKGROUND: The role of mycoplasmas on the development and sequelae of pelvic inflammatory disease remains controversial. The objective of the present study is to correlate directly the presence of Mycoplasmateceae through polimerase chain reaction (PCR) determinations in cervix and Fallopian tubes of infertile patients with tubo-peritoneal factor diagnosed through laparoscopy. METHODS: Thirty patients with tubo-peritoneal infertility and 30 normal fertile patients were included in the study; cervical samples and tubal flushings were obtained during laparoscopy. PCR determinations for the detection of genetic material of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealiticum, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycoplasma; Mycoplasmateceae; Fallopian tubes; Tuboperitoneal infertility; Infections transmitted sexually.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300010

Mycotic thoracoabdominal aortic aneurysm caused by Salmonella cholerasuis
Provedor de dados: 55
Autores: Jalali,Ziba; Madariaga,Miguel; Khoynezhad,Ali.
Tipo: Info:eu-repo/semantics/report
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400018

Myroides odoratimimus soft tissue infection in an immunocompetent child following a pig bite: case report and literature review
Provedor de dados: 55
Autores: Maraki,Sofia; Sarchianaki,Emmanouela; Barbagadakis,Sophia.
Members of the genus Myroides are aerobic Gram-negative bacteria that are common in environmental sources, but are not components of the normal human microflora. Myroides organisms behave as low-grade opportunistic pathogens, causing infections in severely immunocompromised patients and rarely, in immunocompetent hosts. A case of Myroides odoratimimus cellulitis following a pig bite in an immunocompetent child is presented, and the medical literature on Myroides spp. soft tissue infections is reviewed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Myroides species; Soft tissue infection; Child; Immunocompetent.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400015

Nasal carriage of methicillin-resistant Staphylococcus aureus among students at a Louisiana medical university
Provedor de dados: 55
Autores: Bellows,Charles; Smith,Alison; Wheeler,Jean; Morici,Lisa.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100025

Nasal carriage of methicillin-resistant Staphylococcus aureus in university students
Provedor de dados: 55
Autores: Prates,Karina Aparecida; Torres,Ana Maria; Garcia,Lourdes Botelho; Ogatta,Sueli Fumie Yamada; Cardoso,Celso Luiz; Tognim,Maria Cristina Bronharo.
In a study of university students, the percentage nasal carriage of Staphylococcus aureus was 40.8% (102/250). Of the isolates, MIC50 of methicillin was 0.5 µg/mL and MIC90 was 1 µg/mL. Six (5.8%) isolates were methicillin-resistant and carried the mecA gene. These results suggest that community-associated methicillin-resistant S. aureus may be spreading in Brazil.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Nasal carriage; CA-MRSA; S. aureus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300021

Nasopharyngeal colonization and penicillin resistance among pneumococcal strains: a Worldwide 2004 update
Provedor de dados: 55
Autores: Cardozo,Déa M.; Nascimento-Carvalho,Cristiana M. C.; Souza,Fabiane R.; Silva,Nívea M. S.
Surveillance of nasopharyngeal pneumococcus has proven to be a valuable tool for the monitoring of antibiotic resistance. We reviewed the latest information on colonization rate and penicillin resistance by making a MEDLINE search, using the terms "nasopharyngeal carriage" and "Streptococcus pneumoniae". Out of 225 articles found, data from 109 recent publications (89% from 1996-2003) were analyzed. Data were reported from 41 countries of six continents. Individuals under the age of five (64.3%) or 10 years (85.7%) were enrolled, including children attending day-care centers (32.1%) or orphanages (3.6%), and healthy individuals (78.6%) or sick patients (43.6%); biological samples were collected mainly by nasopharyngeal swabs (89.3%). The highest...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Nasopharyngeal carriage; Penicillin resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400015

National Cancer Institute initiatives for international and AIDS-related cancer research
Provedor de dados: 55
Autores: Black,Jodi B.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500032

National estimates of severe sepsis (our experience in Novi Sad, Serbia)
Provedor de dados: 55
Autores: Gvozdenović,Ljiljana; Knežević,Violeta; Knežević,Aleksandar; Gvozdenović,Nemanja; Gojković,Zoran.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300014

Native valve endocarditis and femoral embolism due to Granulicatella adiacens: a rare case report
Provedor de dados: 55
Autores: Vandana,KE; Mukhopadhyay,C; Rau,NR; Ajith,V; Rajath,P.
The fastidious Gram-positive cocci Granulicatella adiacens, previously known as nutritionally variant streptococci (NVS) are unusual but significant cause of endocarditis due to increased mortality and morbidity. Difficulties in reaching correct bacteriological identification, increased resistance to beta-lactam antibiotics and macrolides and complicated clinical course have contributed to problems in management of cases of infective endocarditis caused by this bacterium. We present the first Indian case of endocarditis with arterial embolus by G. adiacens in an elderly male with no preexisting cardiac abnormality
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Endocarditis; Granulicatella adiacens; Femoral embolism.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600015

Natural killer cells in hepatitis B virus infection
Provedor de dados: 55
Autores: Wu,Shao-fei; Wang,Wen-jing; Gao,Yue-qiu.
Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection. Since hepatitis B virus is not cytopathic, the subsequent antiviral immune responses of the host are responsible for sustaining the liver injury, which may result in cirrhosis and even hepatocellular carcinoma. Many studies have conﬁrmed that natural killer cells participate in anti-hepatitis B virus responses both in the early phase after infection and in the chronic phase viacytolysis, degranulation, and cytokine secretion. However, natural killer cells play dichotomic roles: they exert antiviral and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: NK cells; HBV; Review.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400417

Natural YMDD motif mutations in treatment naïve patients with chronic hepatitis B in Huzhou of eastern China
Provedor de dados: 55
Autores: Qian,Fuchu; Qin,Jiqu; Li,Dongli; Zhang,Hairong; Tong,Zhaowei; Wang,Weihong.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600645

Necrotizing fasciitis: eight-year experience and literature review
Provedor de dados: 55
Autores: Wang,Jinn-Ming; Lim,Hwee-Kheng.
OBJECTIVES:To describe clinical, laboratory, microbiological features, and outcomes of necrotizing fasciitis.METHODS:From January 1, 2004 to December 31, 2011, 115 patients (79 males, 36 females) diagnosed with necrotizing fasciitis were admitted to Mackay Memorial Hospital in Taitung. Demographic data, clinical features, location of infection, type of comorbidities, microbiology and laboratory results, and outcomes of patients were retrospectively analyzed.RESULTS:Among 115 cases, 91 survived (79.1%) and 24 died (20.9%). There were 67 males (73.6%) and 24 females (26.4%) with a median age of 54 years (inter-quartile ranges, 44.0-68.0 years) in the survival group; and 12 males (50%) and 12 females (50%) with a median age of 61 years (inter-quartile ranges,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Necrotizing fasciitis; Comorbidity; Debridement; Antibiotics.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200137

Neisseria meningitidis: a neglected cause of infectious haemorrhagic fever in the amazon rainforest
Provedor de dados: 55
Autores: Barroso,David E.; Silva,Luciete A.
Neisseria meningitidis has not been seen as a significant cause of infectious haemorrhagic fever in the Amazon inlands; most reported cases are from the city of Manaus, the capital of the State of Amazonas. This picture is sustained by the lack of reliable microbiology laboratories, the perception of the health care workers, and the difficult to reach medical assistance; thus the number of confirmed cases is even lower with no reference of the strains phenotype. We report here the investigation of a case of suspected meningococcemia and his close contacts in a rural community in the Coari Lake, up the Amazon River.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Meningococcal disease; Haemorrhagic fever; Amazon forest.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600014

Neisseria meningitidis presenting as acute abdomen and recurrent reactive pericarditis
Provedor de dados: 55
Autores: Akinosoglou,Karolina; Alexopoulos,Angelos; Koutsogiannis,Nikolaos; Gogos,Charalampos; Lekkou,Aleksandra.
ABSTRACT Meningococcal meningitis is a well established potential fatal infection characterized by fever, headache, petechial rash, and vomiting in the majority of cases. However, protean manifestations including abdominal pain, sore throat, diarrhea and cough, even though rare, should not be overlooked. Similarly, although disseminated infection could potentially involve various organ-targets, secondary immune related complications including joints or pericardium should be dealt with caution, since they remain unresponsive to appropriate antibiotic regimens. We hereby report the rare case of an otherwise healthy adult female, presenting with acute abdominal pain masking Neisseria meningitidis serotype B meningitis, later complicated with recurrent...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Reactive pericarditis; Neisseria meningitidis; Meningococcal meningitis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600641

Neonatal factors associated with HIV long term non-progressors in a cohort of vertically infected children in Rio de Janeiro, Brazil ("Peixe" Project)
Provedor de dados: 55
Autores: Hofer,Cristina B.; Oliveira,Ricardo Hugo; Machado,Elizabeth S.; Pala,Alessandra; Evangelista,Lúcia; Fernandes,Iraina; Abreu,Thalita F.
There are only scarce data on HIV progression in vertically infected children in developing countries. The aim of this study is to describe factors from neonatal period associated with long term non-progression (LTNP), in a Brazilian cohort. A cohort study, with data systematically collected from the "Peixe" Cohort (cohort study of children conducted at the main HIV Pediatric Center in Rio de Janeiro, from 1996 to 2005). The study included children who were vertically infected and started follow up at 5 years of age or younger. LTNP, defined as not reaching category C or severe immunosuppression before 5 years of age. Neonatal and demographic factors were studied. Variables with p-value&lt;0.15 were included in a logistic regression model. 213 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Long term non-progressors; Children; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400007

Nephrin gene expression in chronic kidney disease of dogs with Leishmania (Leishmania) infantum chagasi
Provedor de dados: 55
Autores: Torres,Mariana de Medeiros; Chitarra,Cristiane Silva; Nakazato,Luciano; Almeida,Arleana Bom Parto Ferreira de; Sousa,Valéria Régia Franco.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500516

Nephrotoxicity during tenofovir treatment: a three-year follow-up study in a Brazilian reference clinic
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Bassetti,Bil Randerson; Fraga,Igor Hernandes Valvassoura; Oliveira Santos,Carolina Rocio; Ximenes,Paula Daher; Miranda,Angélica Espinosa.
Abstract In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine levels and estimated clearance at 0, 6, 12, 24 and 36 months, adjusting for the co-variables sex, skin color, age &gt;50 years, arterial hypertension, diabetes and the use of the ritonavir-boosted protease inhibitors (PI/r) lopinavir/r or atazanavir/r. The software package STATISTICA 10® was used for statistical analysis. The patients’ mean age was 43.2 ± 10.7 years. Systemic arterial hypertension (SAH) and diabetes were found in 20.4% and 8.7% of the patients, respectively. Overall, 96.7% were on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tenofovir; Nephrotoxicity; Impaired renal function; HIV.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100014

Neurobrucellosis: a rare cause for spastic paraparesis
Provedor de dados: 55
Autores: Ahmed,Rishad; Patil,Basanagouda S.
A 41 year old man presented to the outpatient department with a three month history of difficulty in walking. He also had a history of positive sensory symptoms in the form of pins and needle sensation mostly below the waist. His symptoms had been progressive and there was no significant family history. He demonstrated a spastic gait and could only walk with assistance and support. DTR were hypertonic and sensory deficit was observed below twelfth dorsal vertebra. Sphincter abnormalities were present. Plantars were extensor bilaterally. Cerebral and spinal MRI with contrast was unremarkable. Brucella antigen titers were significantly high. CSF report was consistent with neurobrucellosis. After detailed analysis of his history, clinical picture and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Spastic paraparesis; Paraplegia; Brucellosis; Neurobrucella.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300019

Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region
Provedor de dados: 55
Autores: Ceran,Nurgul; Turkoglu,Recai; Erdem,Ilknur; Inan,Asuman; Engin,Derya; Tireli,Hulya; Goktas,Pasa.
Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinical manifestations consist of pseudotumor cerebri in one case, white matter lesions and demyelinating syndrome in three cases, intracranial granuloma in one case, transverse myelitis in two cases, sagittal sinus thrombosis in one case, spinal arachnoiditis in one case, intracranial vasculitis in one case, in addition to meningitis in all cases. Eleven patients were male and seven were female. The most prevalent symptoms were headache (83%) and fever (44%). All...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neurobrucellosis; Serology; Diagnosis; Neuroimaging.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100010

Neurologic complications of HIV in the HAART era: where are we?
Provedor de dados: 55
Autores: Silva,Monica M. Gomes da.
Human immunodeficiency virus (HIV)-associated neurological complications continue to occur despite the development in antiretroviral treatment. New forms of old opportunistic infections and increased prevalence of neurocognitive disorders are the challenges that infectious diseases specialists face in daily clinic. How to screen and treat these disorders are subject of debate and new studies are underway to answer these questions. This review focuses on a brief discussion about opportunistic infections still present in late diagnosed HIV-infected patients and describes new forms of HIV-related neurological complications.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Neurological complication; HAND; Cognitive impairment.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400011

Neurological opportunistic diseases in HIV infected patients in a western hospital of Venezuela, 2007 -2009
Provedor de dados: 55
Autores: Herrera-Martínez,Aura D; Herrera-Martínez,Yiraldine; Pineda,Antonio Maria.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600019

Neurological profile and neurodevelopment of 88 children infected with HIV and 84 seroreverter children followed from 1995 to 2002
Provedor de dados: 55
Autores: Tahan,Tony Tannous; Bruck,Isac; Burger,Marion; Cruz,Cristina Rodrigues.
This study evaluated the degree of neurological compromise in HIV-infected children accompanied by the outpatient clinic of infectious diseases and pediatric neurology of the Clinical Hospital of the Federal University of Paraná (UFPR) starting in 1995. Long-term progressive prospective and cross sectional study of 88 children infected by HIV and 84 seroreverter children, using data from general neurological examinations, neuroimaging procedures (brain CT scan) and neurodevelopmental tests (CAT/CLAMS and DENVER I and II). Neurological and neurodevelopmental alterations were found in 82% of the HIV-infected patients and in 36% of the HIV-seroreverter group (P &lt;0.01). In the CAT/CLAMS test, the development quotient (DQ) of the HIV-infected group was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-infected children; HIV-seroverter children; CAT/CLAMS; DENVER I; DENVER II; Neurodevelopment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500004

Neurotoxoplasmosis diagnosis for HIV-1 patients by real-time PCR of cerebrospinal fluid
Provedor de dados: 55
Autores: Nogui,Fábio Luís Nascimento; Mattas,Sandro; Turcato Júnior,Gilberto; Lewi,David Salomão.
Encephalitis caused by Toxoplasma gondii is the most common cause of central nervous system damage in patients with acquired immunodeficiency syndrome (AIDS). Toxoplasma may infect any of the brain cells, thus leading to non-specific neurotoxoplasmosis clinical manifestations including focused or non-focused signs and symptoms of central nervous system malfunction. Clinical development ranges from insidious display during weeks to experiencing acute general confusion or ultimately fatal onset. Cerebral toxoplasmosis occurs in advanced stages of immunodeficiency, and the absence of anti-toxoplasmosis antibodies by the immunofluorescence method does not allow us to rule out its diagnosis. As specific therapy begins, diagnosis confirmation is sought through...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Cerebral toxoplasmosis; Real time polymerase chain reaction.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100006

Nevirapine-induced side effects in pregnant women: experience of a brazilian university hospital
Provedor de dados: 55
Autores: Kondo,William; Carraro,Elaine Aparecida; Prandel,Elaine; Dias,Josiane Mourão; Perini,Juliane; Macedo,Rodolfo Lara de; Cornelsen,Taynah Cristina; Sbalquiero,Renato; Sasaki,Maria das Graças.
Nevirapine-based therapy is associated with increased frequency of adverse events among HIV-infected pregnant women. The aim of this article was to evaluate the incidence of adverse effects in HIV-infected women who started nevirapine during pregnancy. A retrospective study was performed in our center between January 2003 and December 2006 analyzing all women prescribed nevirapine during pregnancy. Women presenting any risk factor for hepatotoxicity were excluded from the analysis. Patients were divided into two groups according to the presence or absence of adverse effects, and a correlation to CD4 counts was performed. Liver function abnormality was graded according to the Division of AIDS toxicity guidelines. A total of 170 women initiated nevirapine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatotoxicity; HIV-1; Nevirapine; Pregnancy; Toxicity.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600004

New Challenges and rising expectations for the Brazilian Journal of Infectious Diseases, 2019
Provedor de dados: 55
Autores: Goldani,Luciano Z.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100001

New patterns of HCV subtypes distribution in the Khyber Pakhtunkhwa province of Pakistan
Provedor de dados: 55
Autores: Gul,Amina; Ahmed,Jawad; Zahir,Fazli; Ali Khan,Imtiaz; Ali,Ijaz.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100107

New therapeutic approaches for HIV and EBV related lymphomas
Provedor de dados: 55
Autores: Harrington, Jr.,William J.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500019

New therapy of pleural empyema by deoxyribonuclease
Provedor de dados: 55
Autores: Kacprzak,Grzegorz; Majewski,Andrzej; Kolodziej,Jerzy; Rzechonek,Adam; Gürlich,Robert; Bobek,Vladimir.
Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Empyema; Lung; Viscosity; Deoxyribonuclease.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100015

Newborn with rash due to Klebsiella infection
Provedor de dados: 55
Autores: Martínez-Bucio,Víctor; López-Valdés,Julio César.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200199

Next-generation sequencing virulome analysis of a Yersinia enterocolitica subsp. palearctica bioserotype 4/O:3 ST18 isolated from human blood in Brazil
Provedor de dados: 55
Autores: Rusak,Leonardo Alves; Junqueira,Ricardo Magrani; Hofer,Ernesto; Vallim,Deyse Christina; Asensi,Marise Dutra.
Abstract Yersinia enterocolitica is a widespread Gram-negative bacterium that causes gastrointestinal disease and other clinical manifestations in humans. Potentially pathogenic Y. enterocolitica has been isolated in Brazil, from human, environmental, food, and animal sources. Herein we report a genome sequence of Y. enterocolitica subsp. palearctica strain YE 19, serotype O:3, biotype 4, sequence type 18, with virulence determinants isolated from human blood in Rio de Janeiro in 2005. The results corroborate other findings that this strain harbors a set of virulence determinants that could play a role in host pathoadaptation and may also justify the successful dissemination of bioserotype 4/O:3 in Brazil. The presence of strains harboring all of these...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Yersinia enterocolitica; Virulence; Brazil; Next-generation sequencing.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500550

No blood culture examinations during off-hours?
Provedor de dados: 55
Autores: Hagiya,Hideharu.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300330

Nocardia veterana: disseminated infection with urinary tract infection
Provedor de dados: 55
Autores: Poisnel,Elodie; Roseau,Jean-Baptiste; Landais,Cécile; Rodriguez-Nava,Veronica; Bussy,Emmanuel; Gaillard,Tiphaine.
Nocardia spp. are a group of aerobic actinomycetes widely distributed in soil, and associated with severe opportunistic infections, essentially pulmonary infections. We report the ﬁrst case of disseminated infection associated with urinary tract infection caused by Nocardia veterana . The diagnosis was difﬁcult; despite the presence of pulmonary nodules, the lung biopsies remained negative while only one aerobic blood culture and the urine culture were positive for N. veterana , identiﬁed after a 16S rDNA gene sequence analysis. Few cases of clinical importance due to N. veterana have been published since its characterization. The bacteriological diagnosis of nocardiosis can be difﬁcult to establish because of the delayed growth and the speciﬁc techniques...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nocardia veterana; Urinary tract infection; MALDI-TOF MS system; 16S rDNA gene sequencing.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200216

Non Hodgkin's lymphoma with cutaneous involvement in AIDS patients: report of five cases and review of the literature
Provedor de dados: 55
Autores: Corti,Marcelo; Carolis,Luis De; Solari,Rubén; Villafañe,María F; Schtirbu,Ricardo; Lewi,Daniel; Narbaitz,Marina.
Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cell lymphomas presenting clinically in the skin without evidence of extra-cutaneous involvement has been accepted as primary CBCL. Here, we are presenting 5 patients with cutaneous involvement in the setting of HIV/AIDS disease. Two of them were primary cutaneous non-Hodgkin lymphomas. All were CBCL; 3 were immunoblastic, 1 was plasmablastic, and the other was a...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; HIV; Cutaneous lymphoma.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100016

Non tuberculous mycobacteria and toxoplasma co-infection of the central nervous system in a patient with AIDS
Provedor de dados: 55
Autores: Sardar,Partha; Bandyopadhyay,Dipanjan; Roy,Deeptarka; Guha,Pradipta; Guha,Goutam; Banerjee,Amit Kumar.
New-onset seizures are frequent manifestations in patients infected with Human Immunodeficiency Virus (HIV). We describe the clinical and radiological findings in an 25yr old AIDS patient presenting with new onset seizures as the primary manifestation of cerebral toxoplasmosis and Non Tuberculous Mycobacterial [NTM] co-infection. Cranial computed tomography showed a subtle ventricular dilatation whereas magnetic resonance imaging disclosed prominent temporal horn. Toxoplasma tachyzoites and rapidly growing mycobacteria were recovered from CSF. Seizures were complex partial in nature and refractory to antiepileptic therapy.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Non tuberculous Mycobacteria; Toxoplasmosis; HIV; Seizures.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600011

Noncompliance with tuberculosis treatment by patients at a tuberculosis and AIDS reference hospital in midwestern Brazil
Provedor de dados: 55
Autores: Rabahi,Marcelo Fouad; Rodrigues,Adriana Batista; Mello,Fernanda Queiroz de; Almeida Netto,Joaquim Caetano de; Kritski,Afrânio Lineu.
Introduction: In developing countries, there is little information about the risk factors that predict noncompliance with tuberculosis (TB) treatment in hospitals. Objective: This study analyzes possible factors associated with noncompliance with TB treatment among patients treated at HAA. Design: A retrospective cohort study was made including all patients who initiated TB treatment at HAA, from January to December 1998. A standard form was used to review medical records and to collect data on each patient. This data was evaluated in comparison with data from the state TB control program. Results: Of the 341 patients included in the study, 186 (61.2%) were considered cured and 67 (22%) were non-compliant. The factors associated with noncompliance were:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Treatment; Compliance; TB control program; Goiânia.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200002

Noninvasive means of diagnosing liver fibrosis in hepatitis C
Provedor de dados: 55
Autores: Gonçales,Eduardo Sellan Lopes; Angerami,Adriana Flávia Feltrim; Gonçales Junior,Fernando Lopes.
Tipo: Info:eu-repo/semantics/article
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600001

Non-polarized cytokine profile of a long-term non-progressor HIV infected patient
Provedor de dados: 55
Autores: Pina,Ana Flávia; Matos,Vanessa Terezinha Gubert de; Bonin,Camila Mareti; Dal Fabbro,Márcia Maria Ferrairo Janini; Tozetti,Inês Aparecida.
ABSTRACT The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Interleukins; HIV seropositivity; Disease progression; Antiretroviral therapy.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200142

Nontuberculosis mycobacteria at a multiresistant tuberculosis reference center in Bahia: clinical epidemiological aspects
Provedor de dados: 55
Autores: Matos,Eliana Dias; Santana,Maria Angélica; Santana,Mariana Costa de; Mamede,Patrícia; Bezerra,Bianca de Lira; Panão,Eliana Daltro; Schitini Filho,Clovis S.; Lemos,Antônio Carlos M.
OBJETIVO: Examine the prevalence and clinical/epidemiological aspects of patients with nontuberculous mycobacteria (NTM) isolated from sputum provided by an outpatient clinic specializing in the treatment of multiresistant tuberculosis (MRTB) in Bahia, Brazil. METHODS: All patients followed at the MRTB outpatient clinic of the Octávio Mangabeira Specialized Hospital (HEOM) were evaluated retrospectively from July 1998 to July 2003. All patients underwent direct examinations and cultures to identify the mycobacteria species found during initial and subsequent evaluations. The following variables were recorded: age, gender, clinical symptoms and signs, pre-existing lung disease, prior TB treatment, HIV serology, and NTM species. Categorical and quantitative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nontuberculous mycobacteria; Lung disease; Brazil; Bahia.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400005

Norovirus and Rotavirus infection in children aged less than ﬁve years in a paediatric hospital, Havana, Cuba
Provedor de dados: 55
Autores: Ribas,María de los Angeles; Castaño,Yuselis; Martínez,Marlon Daniel; Tejero,Yahisel; Cordero,Yanislet.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200222

Nosocomial and community infections due to class A extended-spectrum β-lactamase (ESBLA)-producing Escherichia coli and Klebsiella spp. in southern Brazil
Provedor de dados: 55
Autores: Wollheim,Claudia; Guerra,Ivani Maria F; Conte,Vania D; Hoffman,Sheila P; Schreiner,Fernando J; Delamare,Ana Paula L; Barth,Afonso L; Echeverrigaray,Sérgio; Costa,Sérgio Olavo P da.
OBJECTIVES: To determine the prevalence of class A extended spectrum β-lactamases (ESBL)-producing Escherichia coli and Klebsiella spp., and to investigate clonality among ESBL-producing isolates of nosocomial and community infections. METHODS: The study involved 354 nosocomial infections samples and 992 community infections samples, obtained between 2003 and 2006 at Caxias do Sul, RS. The detection of ESBL was performed by the disk-diffusion test. Presence of blaCTX-M, blaSHV and blaTEM β-lactamase genes was evaluated by PCR, and genomic typing was determined by pulsed-field gel electrophoresis analysis. RESULTS: Higher frequency of ESBL-producing isolates were detected among nosocomial samples of E. coli (6.7%) and Klebsiella (43.7%), than those obtained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Β-lactamases; Polymerase chain reaction; Bacterial typing techniques.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200008

Nosocomial bloodstream infections: organisms, risk factors and resistant phenotypes in the Brazilian University Hospital
Provedor de dados: 55
Autores: Ribas,Rosineide M.; Freitas,Claudete; Gontijo Filho,Paulo P.
Bacteremia is one of the most frequent and challenging hospital-acquired infection and it is associated with high attributable morbidity and mortality and additional use of healthcare resources. The objective of this work was to determine the frequencies of its occurrence, organisms and resistance phenotypes associated to nosocomial acquired bloodstream infections. A total number of 51 nosocomial bacteremia by Gram-negative and 99 by Gram-positive were evaluated and compared during a 15-month period. The risk factors associated with these bacteremias were analyzed and antibiotic use and surgery were associated with bacteremia by Gram-negative and &gt; 2 invasive devices with Gram-positive. The resistance phenotypes ESBL (extended-spectrum beta-lactamases)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial bacteremia; Resistance phenotypes; Risk factors.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300010

Nosocomial diarrhea in the intensive care unit
Provedor de dados: 55
Autores: Marcon,Ana Paula; Gamba,Mônica Antar; Vianna,Lucila Amaral Carneiro.
We made an epidemiological case-control study to examine risk factors for the development of diarrhea in the intensive care unit (ICU) of a public hospital in Santo André, SP, from January to October 2002. Forty-nine patients with diarrhea (cases) and 49 patients without diarrhea (controls), matched for age and gender, were included in the study. A stool culture and enzyme immunoassays for Clostridium difficile toxins A and B were performed on fecal specimens from diarrhea patients. Fourteen of them presented positive cultures for Pseudomonas aeruginosa and 22 patients presented positive ELISA for Clostridium diffícile. Nosocomial diarrhea was associated with several factors, including use of antibiotics (P=0.001), use of ceftriaxone (P=0.001), presence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infections; Diarrhea; Antibiotics; Intensive care; Clostridium difficile.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600005

Nosocomial infection in a pediatric intensive care unit in a developing country
Provedor de dados: 55
Autores: Abramczyk,Marcelo L.; Carvalho,Werther B.; Carvalho,Eduardo S.; Medeiros,Eduardo A. S.
OBJECTIVE: Determine the rate and outcome of nosocomial infection (NI) in pediatric intensive care unit patients in a developing country. DESIGN: Prospective cohort study using the Centers for Disease Control and Prevention definitions to diagnose nosocomial infection and NNISS (National Nosocomial Infection Surveillance System) methodology. SETTING: São Paulo Hospital - Universidade Federal de São Paulo - Brazil, a 700-bed teaching hospital with an 8-bed pediatric intensive care unit. PARTICIPANTS: All 515 children consecutively admitted to the pediatric intensive care unit from April 1996 to October 1997. RESULTS: The NI incidence was 18.3% and the mean infection rate per 1,000 patient days was 46.1; the ventilator-associated pneumonia rate was 18.7 per...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infections; Pediatric ICU; Pneumonia.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600004

Nosocomial infections caused by Elizabethkingia meningoseptica: an emergent pathogen
Provedor de dados: 55
Autores: Pereira,Graziella H.; Garcia,Doroti de Oliveira; Abboud,Cely Saad; Barbosa,Vera Lucia de Barros; Silva,Paulo Sérgio Lucas da.
We hereby describe the clinical and epidemiological features and, outcomes of nine patients with Elizabethkingia meningoseptica infections in two hospitals over a 2-year period. All infections caused by this pathogen were nosocomial, or healthcare associated infections, in hemodialysis settings whereas none was correlated with hospital outbreaks.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Elizabethkingia meningoseptica; Nosocomial infections; Bloodstream infections.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500015

Nosocomial infections in brazilian pediatric patients: using a decision tree to identify high mortality groups
Provedor de dados: 55
Autores: Lopes,Julia M.M.; Goulart,Eugenio M.A.; Siqueira,Arminda L.; Fonseca,Inara K.; Brito,Marcus V.S. de; Starling,Carlos E.F.
Nosocomial infections (NI) are frequent events with potentially lethal outcomes. We identified predictive factors for mortality related to NI and developed an algorithm for predicting that risk in order to improve hospital epidemiology and healthcare quality programs. We made a prospective cohort NI surveillance of all acute-care patients according to the National Nosocomial Infections Surveillance System guidelines since 1992, applying the Centers for Disease Control and Prevention 1988 definitions adapted to a Brazilian pediatric hospital. Thirty-eight deaths considered to be related to NI were analyzed as the outcome variable for 754 patients with NI, whose survival time was taken into consideration. The predictive factors for mortality related to NI (p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; Healthcare quality; Mortality; Nosocomial infection; Pediatric hospital.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200008

Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa carrying blaVIM-2 in burn wards, China
Provedor de dados: 55
Autores: Zhang,Ruowen; Mingcheng,Li; Dong,Xueyan; Li,Fan.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500021

Nosocomial outbreak of Pantoea agglomerans in a pediatric urgent care center
Provedor de dados: 55
Autores: Bicudo,Eliana L.; Macedo,Vanise O.; Carrara,Marlene A.; Castro,Fabíola F.S.; Rage,Ruth I.
Pantoea agglomerans is a Gram-negative bacterium whose isolates can be found in blood cultures and other secretions. This article described one outbreak of sepsis due to this bacterium in the pediatric urgent care center of a tertiary hospital, in Brasilia, Federal District. This was a case-control study and it evaluated the risk factors for acquisition of nosocomial sepsis caused by Pantoea agglomerans. Six case-patients and 15 control-patients have been found. The risk factors were: vomiting in the internment and presence of solution compositions in the intravenous hydration therapy received in bigger number than 2 compositions. The transference tube used for the compositions was contaminated with Pantoea agglomerans, characterizing the outbreak with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pantoea agglomerans; Pediatric; Nosocomial outbreak.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200023

Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model
Provedor de dados: 55
Autores: Zhang,Jingmin; Wang,Yafeng; Peng,Youmei; Qin,Chongzhen; Liu,Yixian; Li,Jingjing; Jiang,Jinhua; Zhou,Yubing; Chang,Junbiao; Wang,Qingduan.
ABSTRACT Antiviral drug resistance is the most important factor contributing to treatment failure using nucleos(t)ide analogs such as lamivudine for chronic infection with hepatitis B virus (HBV). Development of a system supporting efficient replication of clinically resistant HBV strains is imperative, and new antiviral drugs are needed urgently to prevent selection of drug-resistant HBV mutants. A novel fluorinated cytidine analog, NCC (N-cyclopropyl-4′-azido-2′-deoxy-2′-fluoro-β-d-cytidine), was recently shown to strongly inhibit human HBV in vitro and in vivo. This study was designed to evaluate the antiviral activity of NCC against lamivudine-resistant HBV. We generated a stable cell line encoding the major pattern of lamivudine-resistant mutations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: N-cyclopropyl-4′-azido-2′-deoxy-2′-fluoro-β-D- cytidine; Hepatitis B virus; HepG2.RL1 cells; Lamivudine-resistant; RtL180M/M204V.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600477

Novel pharmaceutical molecules against emerging resistant gram-positive cocci
Provedor de dados: 55
Autores: Manfredi,Roberto; Sabbatani,Sergio.
INTRODUCTION: methicillin- and also vancomycin (glycopeptide)-resistant Gram-positive organisms have emerged as an increasingly problematic cause of hospital-acquired infections, also spreading into the community. Vancomycin (glycopeptide) resistance has emerged primarily among Enterococci, but the MIC values of vancomycin for the entire Staphylococcus species are also increasing worldwide. MATERIAL AND METHODS: the aim of our review is to evaluate the efficacy and tolerability of newer antibiotics with activity against methicillin-resistant and glycopeptide-resistant Gram-positive cocci, on the ground of our experience at a tertiary care metropolitan Hospital, and the most recent literature evidences in this field. RESULTS: Quinupristin-dalfopristin,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Resistant gram-positive cocci; Staphylococci; Enterococci; Pneumococci; Streptococci; Epidemiology; Clinical issues; Novel antimicrobial compounds; Characteristics; Literature evidences.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100020

Obscure gastrointestinal bleeding caused by hookworms
Provedor de dados: 55
Autores: Yi,Fengming; Huang,Meifang.
Tipo: Info:eu-repo/semantics/report
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200026

Occult B infection in the Brazilian northeastern region: a preliminary report
Provedor de dados: 55
Autores: Almeida,Delvone; Tavares-Neto,José; Trepo,Christian; Almeida,Alessandro; Mello,Caroline; Chemin,Isabelle; Paraná,Raymundo.
A sentinel study on viral hepatitis is currently being carried out in the village of Cavunge in a semiarid rural region of the state of Bahia, northeastern Brazil. This study has identified individuals in whom anti-HBc IgG was the only serological marker for hepatitis B virus (HBV). This serological pattern may constitute evidence of occult HBV infection. This study Investigated the possibility of occult hepatitis B virus infection in individuals in a rural community who tested positive for anti-HBc IgG alone. A cross-sectional population-based study. ELISA III was performed on serum samples to test for serological viral markers, and ultrasensitive PCR (US-PCR) was used to assess viremia. Among the 1,536 serum samples, 3.6% (n=55) were positive for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-HBc alone; Hepatitis B virus; Occult hepatitis B; Ultrasensitive PCR.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400010

Occult hepatitis B virus infection in immunocompromised patients
Provedor de dados: 55
Autores: Jardim,Ruth Nogueira Cordeiro Moraes; Gonçales,Neiva Sellan Lopes; Pereira,Josiane Silveira Felix; Fais,Viviane Cristina; Gonçales Junior,Fernando Lopes.
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Occult HBV infection; HBV-DNA; Anti-HBc alone; Hemodialysis; HIV; Immunosupressed patients.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008

Occupational and nosocomial transmission of varicella
Provedor de dados: 55
Autores: Façanha,Mônica Cardoso; Monroe,Antonia Célia Pinheiro.
We examined varicella transmission in a hospital specialized in cancer treatment. A cases series study was made of a case of intra-hospital transmission of varicella, based on a revision of the records of patients who had been admitted during the time the index case was in the same service. Records of interviews of employees were also reviewed. During the period that the index case was in the intensive care unit, 34 patients were admitted and 35 employees worked there. Two employees and a patient developed the illness, due to transmission directly or indirectly from the index case. Although this is a service in which most of the patients are adults who have cancer, attention needs to be directed towards diagnosis and to procedures to reduce the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Varicella; Varicella-zoster infection; Chickenpox; Occupational illness; Hospital Infection.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200016

Occurrence of extended-spectrum beta-lactamases in Enterobacteriaceae isolated from hospitalized patients in Curitiba, southern Brazil
Provedor de dados: 55
Autores: Nogueira,Keite da Silva; Higuti,Ilma Hiroko; Nascimento,Agnaldo José do; Terasawa,Larissa Bail; Oliveira,Simone de; Matos,Adriana Pereira; Souza,Helena Aguilar Peres Homem de Mello de; Cogo,Laura Lúcia; Dalla Costa,Libera Maria.
Production of extended-spectrum beta-lactamases (ESBL) by enterobacteria is an important resistance mechanism against antimicrobial beta-lactamics. We tested 498 bacterial strains isolated from two tertiary-care teaching hospitals for ESBL production, using screening breakpoints for aztreonam and third generation cephalosporins, according to CLSI recommendations. Among these isolates, 155 were positive for the ESBL screening test, and 121 (78%) were confirmed by the clavulanic acid combination disk method. We found a high frequency of ESBL (24%) among Enterobacteriaceae, with a frequency of 57.4% for Klebsiella pneumoniae, 21.4% for Klebsiella oxytoca, and 7.2% for E. coli. In other members of Enterobacteriaceae, non-Klebsiella and non-E. coli, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL; Beta-lactamases; Enterobacteriaceae.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600006

Occurrence of hemoplasmas in free-ranging and captive wild felines
Provedor de dados: 55
Autores: Pitchenin,Letícia Camara; Maruyama,Fernanda Harumi; Morgado,Thais de Oliveira; Dutra,Valeria; Nakazato,Luciano.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200146

Occurrence of hepatitis B virus genotype B and B + C mixed infections in Chennai, South India
Provedor de dados: 55
Autores: Koli,Suneeta; Radhakrishnan,Anand Narayanan Pallipurath; Jacob,Melvin; Vadivoo,Selvaraj; Purushothaman,Girish Kumar Chethrapilly.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500018

Ocular infection associated with Delftia lacustris: ﬁrst report
Provedor de dados: 55
Autores: Sohn,Kyung Mok; Baek,Jin-Yang; Cheon,Shinhye; Kim,Yeon-Sook; Koo,Sun Hoe.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400449

Ocular problems in brazilian patients with AIDS before and in highly active antiretroviral therapy (HAART) era
Provedor de dados: 55
Autores: Rodrigues,Marcia Lopes; Rodrigues,Maria de Lourdes Veronese; Figueiredo,José Fernando de Castro; Freitas,João Alberto Holanda de.
This study determined the total frequency of patients with AIDS and ophthalmologic problems before and after the introduction of combined highly active antiretroviral therapy (HAART), regardless of the use of this treatment; it also determined the frequency of external ocular diseases, intraocular infections and inflammations, and problems of the anterior portion of the optic nerve in these two groups of patients; and it determined the differences in the frequency of ophthalmologic problems in patients receiving HAART or not. This was a retrospective study of 207 patients examined using the same protocol, from June 1995 to February 1998 (n=58, pre-HAART era) and from March 1998 to May 2005 (n=149, HAART era). The frequency of ophthalmologic problems was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ocular problems; AIDS; HAART.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200005

Odontogenic infections in the Internal Medicine Service
Provedor de dados: 55
Autores: Gilardi,Leonardo.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600022

Olecranon bursitis caused by group C streptococcus in a patient with tophaceous gout
Provedor de dados: 55
Autores: Morsch,Claudine Predebon; Batistella,Fabio; Staub,Henrique Luiz.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100024

Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder
Provedor de dados: 55
Autores: Carneiro Neto,Jose Abraão; Santos,Silvane Braga; Orge,Gloria Orge; Tanajura,Davi; Passos,Lucia; Oliveira,Cassius José; Andrade,Rosana; Melo,Cláudio Galeno de; Barroso Jr,Ubirajara; Carvalho,Edgar M.
ABSTRACT  Aim: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL).  Methods: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire.  Results: The mean (SD) of the age was 52 + 14.5 years and 60% were female. All of them had confirmed detrusor overactivity on urodynamic study. Seven patients had HAM/TSP. The median and range of the OABSS was 13 (12–15) before therapy and decreased to 1.0 (0–12) on day 30 and to 03 (0–14)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Overactive bladder; Onabotulinum toxin; HTLV-1.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200079

One-step real-time PCR assay for detection and quantification of RNA HCV to monitor patients under treatment in Brazil
Provedor de dados: 55
Autores: Andrade,Elisabete; Rocha,Daniele; Fontana-Maurell,Marcela; Costa,Elaine; Ribeiro,Marisa; de Godoy,Daniela Tupy; Ferreira,Antonio G.P.; Tanuri,Amilcar; Alvarez,Patrícia; Brindeiro,Rodrigo.
ABSTRACT The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. The primary goal of HCV therapy is the long-term elimination of HCV from the blood to reduce the risk of HCV associated complications and death. Patient viremia affects the treatment duration and response, thus influencing clinical decisions. We developed a high-throughput method to perform the quantification of RNA hepatitis C virus (HCV) virus load in plasma samples to monitor patients under treatment. The method is based on a duplex detection, in a one-step real-time RT-PCR assay and it has been validated according to the rules established by the official Brazilian regulatory agency (ANVISA). This new method was compared to a commercial kit...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; Viral load; Real Time PCR; Monitoring patients.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500418

Online continuing interprofessional education on hospital-acquired infections for Latin America
Provedor de dados: 55
Autores: Medina-Presentado,Julio C.; Margolis,Alvaro; Teixeira,Lucia; Lorier,Leticia; Gales,Ana C.; Pérez-Sartori,Graciela; Oliveira,Maura S.; Seija,Verónica; Paciel,Daniela; Vignoli,Rafael; Guerra,Silvia; Albornoz,Henry; Arteta,Zaida; Lopez-Arredondo,Antonio; García,Sofía.
Abstract  Introduction: Latin America is a large and diverse region, comprising more than 600 million inhabitants and one million physicians in over 20 countries. Resistance to antibacterial drugs is particularly important in the region. This paper describes the design, implementation and results of an international bi-lingual (Spanish and Portuguese) online continuing interprofessional interactive educational program on hospital-acquired infections and antimicrobial resistance for Latin America, supported by the American Society for Microbiology.  Methods: Participation, satisfaction and knowledge gain (through pre and post tests) were used. Moreover, commitment to change statements were requested from participants at the end of the course and three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Internet; Continuing education; Interprofessional education; MOOC; Hospital-acquired infections; Latin America.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200140

Onset of opportunistic infections in patients co-infected by HTLV-1 and HIV-1, with high CD4+ cells count
Provedor de dados: 55
Autores: Regis,Catarin; Oliveira,Adriano; Brites,Carlos.
We reported two cases of patients with coinfection by human immunodeficiency virus (HIV) type 1 and human T-cell lymphotropic virus (HTLV) type I who developed opportunistic infections despite of relatively high CD4+ cells count. These cases showed clinical evidence to consider an earlier antiretroviral treatment for coinfected patientes regardless CD4+ cells counts.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV-1/HTLV-1 co-infection; Opportunistic infections; CD4.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400014

Oral HPV infection in a bone marrow transplantation patient: a case report with atypical clinical presentation and unexpected outcome
Provedor de dados: 55
Autores: Pereira,Claudio Maranhão; Melo,Laura Guimarães; Correa,Maysa Milazzo; Souza,Cármino Antônio; Corrêa,Maria Elvira P.
HPV (Human Papilloma Virus) is one of the most prevalent infections worlwide. Oral HPV infection may be associated with different diseases of oral cavitie. Although oral HPV infection occurs frequently, it rarely causes lesions. An increased rate of oral HPV-induced lesions is observed in people with an impaired immune system. The most common conditions induced by oral HPV infection are focal epithelial hyperplasia, oral condylomas and oral papillomas. We reported a case of oral HPV lesion in a bone marrow transplantation patient with atypical clinical presentation and unexpected outcome.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HPV; Bone marrow transplantation; Leukemia.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100018

Oral manifestation of tuberculosis: a case-report
Provedor de dados: 55
Autores: de Souza,Bárbara Capitanio; de Lemos,Vania Maria Aita; Munerato,Maria Cristina.
Abstract The present case-report describes tuberculosis on the oral mucosa, in a rare manifestation of the disease. The importance of appropriate diagnosis and awareness of the clinical manifestations is highlighted. Oral lesions seem to occur as chronic ulcers, nodular or granular areas, and rare, firm leukoplakia regions. Most extra-pulmonary lesions represent secondary infections of a primary lung infectious focus; therefore, early and accurate diagnosis is required for planning of the best treatment and strategies to control the disease.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mycobacterium infection; Oral lesion; Oral tuberculosis; Mycobacterium tuberculosis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200210

Oral miltefosine treatment in children with visceral leishmaniasis: a brief review
Provedor de dados: 55
Autores: Palumbo,Emilio.
Visceral leishmaniasis (VL) or kala-azar is an infection disease caused by hemiflagellate protozoan parasites (Leishmania donovani) and transmitted to humans by the phlebotomine sandfly. Leishmaniasis is distributed worldwide and 13 million people are estimated to be infected, with about 1.8 million new cases each year. All antileishmanial drugs are toxic and most have to be used parenterally for prolonged period. The therapy has been further complicated by large number of infected children and declining effectiveness of pentavalent antimonial compounds. Although the lipid formulations of amphotericin B are an important advance in therapy, their high cost precludes their use. Miltefosine, a phosphocholine analogue originally developed as antimalignant...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Miltefosine; Treatment; Children; Leishmaniasis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100002

Oral paracoccidiodomycosis mimicking lip carcinoma
Provedor de dados: 55
Autores: Girardi,Fábio Muradás; Scrofernecker,Maria Lúcia.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100103

Orf disease: a report of a case
Provedor de dados: 55
Autores: Koufakis,Theocharis; Katsaitis,Periklis; Gabranis,Ioannis.
Tipo: Info:eu-repo/semantics/report
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500568

Oseltamivir as a cause of acute enterorrhagia
Provedor de dados: 55
Autores: Beraldi-Magalhães,Francisco; Batista,Vera; Cordeiro-Santos,Marcelo.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500521

Osteoarthritis in the neonate: risk factors and outcome
Provedor de dados: 55
Autores: Berberian,Griselda; Firpo,Verónica; Soto,Adriana; Lopez Mañan,Julio; Torroija,Cecilia; Castro,Graciela; Polanuer,Pablo; Espinola,Camilo; Piñeiro,José Luis; Rosanova,María Teresa.
OBJECTIVES: The aim of this study was to identify the clinical, radiological, and bacteriological features, risk factors, and outcome of neonates with bone and joint infections. STUDY DESIGN: Observational, retrospective, and analytical study of 77 patients less than 2 months of age, admitted to a tertiary neonatal intensive care unit (NICU) with the diagnosis of bone or joint infection, based on clinical, radiological, and microbiological criteria. RESULTS: Seventy-seven patients with 99 acute osteoarthritis foci in a 16 year period were included in the study. Risk factors for infection could be identified in 69% of the patients. The hip was the most frequent. Staphylococcus aureus was the main isolated microorganism. Twenty-nine infants (38%) had...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Osteoarthritis; Neonate; Staphylococcus aureus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400018

Osteoarticular complications related to HIV infection and highly active antiretroviral therapy
Provedor de dados: 55
Autores: Lima,Ana Lúcia Lei Munhoz; Zumiotti,Arnaldo Valdir; Camanho,Gilberto Luis; Benegas,Eduardo; Santos,Alexandre Leme Godoy dos; D'Elia,Caio Oliveira; Oliveira,Priscila Rosalba Domingos.
With the significant increase in life expectancy for HIV-infected patients in the era of high potency antiretroviral therapy, major metabolic changes have been observed due to the prolonged period of the viral infection and the treatment itself. Osteoarticular changes resulting from these processes are mainly reported in long term HIV-infected patients receiving high potency antiretroviral therapy and include osteopenia/osteoporosis, osteonecrosis, carpal tunnel syndrome and adhesive capsulitis of the shoulder.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired immunodeficiency syndrome; Osteoarticular; Antiretroviral agents.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400012

Osteomyelitis: a current challenge
Provedor de dados: 55
Autores: Jorge,Luciana Souza; Chueire,Alceu Gomes; Rossit,Andréa Regina Baptista.
Over the last 30 years, the pathogenesis of osteomyelitis has almost been totally elucidated, and many factors responsible for the persistence of this infection have been identified. Numerous antimicrobial agents with distinct spectrums of action, pharmacokinetics, and pharmacodynamics have been used in its treatment. Surgical techniques, including muscle grafts, the Ilizarov technique, and antibiotic bone cements, have been applied. However, bone infections are still a challenge. Despite the importance of isolation and identification of microorganisms to determine the antimicrobial treatment of bone infections, there are few systematic national studies about the etiological profile of these diseases. This article describes the current knowledge of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteomyelitis; Arthroplasty; S. aureus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300020

Outbreak of resistant Acinetobacter baumannii: measures and proposal for prevention and control
Provedor de dados: 55
Autores: Romanelli,Roberta Maia de Castro; Jesus,Lenize Adriana de; Clemente,Wanessa Trindade; Lima,Stella Sala Soares; Rezende,Edna Maria; Coutinho,Rosane Luiza; Moreira,Ricardo Luiz Fontes; Neves,Francelli Aparecida Cordeiro; Brás,Nelma de Jesus.
Acinetobacter baumannii colonization and infection, frequent in Intensive Care Unit (ICU) patients, is commonly associated with high morbimortality. Several outbreaks due to multidrug-resistant (MDR) A. baumanii have been reported but few of them in Brazil. This study aimed to identify risk factors associated with colonization and infection by MDR and carbapenem-resistant A. baumannii strains isolated from patients admitted to the adult ICU at HC/UFMG. A case-control study was performed from January 2007 to June 2008. Cases were defined as patients colonized or infected by MDR/carbapenem-resistant A. baumannii, and controls were patients without MDR/carbapenem-resistant A. baumannii isolation, in a 1:2 proportion. For statistical analysis, due to changes...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Multidrug resistance; Carbapenem; Infection control; Outbreak.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500005

Outbreak of vancomycin-resistant Enterococcus in a renal transplant unit
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Penteado-Filho,Sergio Ricardo; Camilotti,Janaina; Heijden,Inneke Marie van der; Costa,Silvia Figueiredo.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400021

Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions
Provedor de dados: 55
Autores: Gomes,Marisa Zenaide Ribeiro; Machado,Carolina Romero; Conceição,Magda de Souza da; Ortega,Jois Alves; Neves,Sonia Maria Ferraz M; Lourenço,Maria Cristina da Silva; Asensi,Marise Dutra.
INTRODUCTION: Authors have reported increased incidence of multiresistant Pseudomonas aeruginosa (MR-PA) infections worldwide over the last decade. Researchers have proposed multifaceted approaches to control MR-PA infections, but none have been reported in the acquired immunodeficiency syndrome (AIDS) setting. OBJECTIVE AND METHODS: Herein we report the impact of a multifaceted intervention for controlling MR-PA over five years in a hospital with AIDS-predominant admissions and describe the clinical characteristics of MR-PA infection in our patient population. The clinical outcomes of infected patients and molecular characteristics of the isolated strains were used as tools for controlling MR-PA infection rates. RESULTS: Significant temporary decrease of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Disease outbreaks; Infection control; Molecular epidemiology; Acquired immunodeficiency syndrome.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400003

Outpatient parenteral antimicrobial therapy for orthopedic infections – a successful public healthcare experience in Brazil
Provedor de dados: 55
Autores: Oliveira,Priscila Rosalba; Felix,Cassia da Silva; Carvalho,Vladimir Cordeiro de; Giovani,Arlete Mazzini; Reis,Rosangela Suarti dos; Beraldo,Marisa; Albuquerque,Edmir Peralta; Ferreira Junior,Walter Cintra; Silva,Jorge dos Santos; Lima,Ana Lucia Lei.
Abstract Treatment of orthopedic infections usually requires prolonged antimicrobial therapy, ranging from 14 days up to 6 months. Nowadays, rising levels of antimicrobial resistance demands parenteral therapy for many patients. Outpatient parenteral antimicrobial therapy (OPAT) is a modality that allows treatment out of hospital in these situations. In Brazil, where a public universal healthcare system allows full coverage for all citizens, implantation and dissemination of OPAT programs would be beneficial for patients and for the system, because it would allow a better allocation of health resources. The Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da USP (IOT) started, in July 2013, a partnership with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Home infusion therapy; Ambulatory care facilities; Public healthcare practice; Osteomyelitis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300009

Over-the-counter human immunodeficiency virus self-test kits: time to explore their use for men who have sex with men in Brazil
Provedor de dados: 55
Autores: Lippman,Sheri A.; Veloso,Valdiléa G.; Buchbinder,Susan; Fernandes,Nilo Martinez; Terto,Veriano; Sullivan,Patrick S.; Grinsztejn,Beatriz.
Increasing access and frequency of human immunodeficiency virus testing are critical to stemming the epidemic. In Brazil's concentrated epidemic, human immunodeficiency virus prevalence in the men who have sex with men/transgender population far exceeds that in the general population, but testing rates fall below what is needed to ensure early detection and treatment. Over-the-counter human immunodeficiency virus self-testing kits, now available in stores in the U.S., have enormous potential to increase testing access and frequency and to facilitate early detection and treatment. With the advent of human immunodeficiency virus self-testing upon us, it is timely to engage the scientific community, government, and civil society in a dialog around how to best...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; HIV testing; MSM; Self-testing; Home-based testing.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300239

Overview of tigecycline and its role in the era of antibiotic resistance
Provedor de dados: 55
Autores: Rossi,Flávia; Andreazzi,Denise.
The increasing antimicrobial resistance found in the many clinically important species of bacteria that commonly cause serious and life-threatening diseases presents a difficult challenge for clinicians, especially when an appropriate initial therapy must be chosen. New antibiotics are urgently needed to address the formidable issues associated with infections caused by vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae and multidrug-resistant Gram-negative bacteria. The need for new antibiotics that effectively resist antimicrobial mechanisms of resistance has become paramount. Tigecycline is a new antimicrobial agent; it is the first in a new class of antibiotics, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tigecycline; Antibiotic resistance; Antimicrobial mechanisms.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300010

Overwhelming diffuse psoriasis during chronic HCV infection, after peginterferon-ribavirin treatment, supported by frequent resort to filgrastim rescue
Provedor de dados: 55
Autores: Sabbatani,Sergio; Manfredi,Roberto.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400001

Oxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism
Provedor de dados: 55
Autores: Oliveira,Yanaihara Pinchemel Amorim de; Pontes-de-Carvalho,Lain Carlos; Couto,Ricardo David; Noronha-Dutra,Alberto Augusto.
Abstract  Background: Sepsis is an illness with a high morbidity for which no effective treatment exists. Its treatment has a high cost because it usually requires an intensive care unit and expensive antibiotics. The present study focus in the production of reactive oxygen species in the early stages of sepsis. This study aimed at investigating the production of reactive oxygen specie during the inflammatory response in patients with sepsis.  Methods: Reactive oxygen specie production and insoluble myeloperoxidase obtained from fresh whole blood were measured by photon counting chemiluminescence in the blood of 18 septic patients and 12 healthy individuals. Modified red blood cells were evaluated by staining of blood smears. The production of reactive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Oxidative stress; Inflammation; Modified erythrocytes.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100019

Pain in hospitalized HIV-positive patients: clinical and therapeutical issues
Provedor de dados: 55
Autores: Aires,Elisa Miranda; Bammann,Ricardo H.
Pain is frequently reported by patients infected with Acquired Immunodeficiency Virus (HIV), and its causes and specific treatment should be appropriately investigated. We evaluated 197 hospitalized HIV-positive patients with serial interviews and analysis of prescriptions and clinical evolution charts. The main characteristics of pain reported by these patients were: high intensity (60.7%), high frequency (72.0%) and well-known causes (88.8%). Fifty-two per cent of the patients reported persistent or frequent pain during the two weeks before hospital admission. Parameters such as gender, educational level and Karnofsky Index showed no direct relation to the presence or absence of pain. The most commonly affected sites were the head (28.0%) and the abdomen...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pain; HIV; AIDS; Analgesic treatment; Undertreatment; Pain management index.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300002

Pain prevalence, characteristics and associated factors in human T-cell lymphotropic virus type 1 infected patients: a systematic review of the literature
Provedor de dados: 55
Autores: San-Martin,Daniel Lordelo; Santos,Dislene Nascimento dos; Baptista,Abrahão Fontes.
ABSTRACT  Objective: To describe the pain in patients infected with human T-cell lymphotropic virus type 1, clinically and epidemiologically.  Methods: This systematic review was based on The PRISMA Statement. Four reviewers searched PUBMED, SciELO, LILACS and BIREME for data from observational studies and clinical trials (n ≥ 30) regarding pain prevalence, characteristics, and associated factors in patients with human T-cell lymphotropic virus type 1. No limits on publication date or language were established. Studies that did not have pain as an outcome measure or not involving human T-cell lymphotropic virus type 1 infected patients were excluded.  Results: A total of 3013 articles (including duplicates) were found of which seven met the predetermined...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; HAM/TSP; Pain; Prevalence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600592

Pakistan as a major obstacle in global end to poliomyelitis program: background and 2016 update
Provedor de dados: 55
Autores: Khan,Abdul Waheed; Ali,Shahid; Ali,Syed Shujait.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500518

Pantoea dispersa: an unusual cause of neonatal sepsis
Provedor de dados: 55
Autores: Mehar,Veerendra; Yadav,Dinesh; Sanghvi,Jyoti; Gupta,Nidhi; Singh,Kuldeep.
Neonatal septicemia is the most important cause of neonatal mortality. A wide variety of bacteria both aerobic and anaerobic can cause neonatal sepsis. Genus Pantoea is a member of Enterobacteriaceae family that inhabits plants, soil and water and rarely causes human infections, however, Pantoea dispersa has not been reported as a causative organism for neonatal sepsis. We hereby report two neonates with early onset sepsis caused by Pantoea dispersa. Early detection and appropriate antibiotic therapy can improve overall outcome of this rare infection in neonates.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Neonatal sepsis; Pantoea dispersa; Enterobacteriacae.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600022

Pantoea dispersa bacteremia caused by central line-associated bloodstream infection
Provedor de dados: 55
Autores: Hagiya,Hideharu; Otsuka,Fumio.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600696

Papillomavirus infections in the oral and genital mucosa of asymptomatic women
Provedor de dados: 55
Autores: Oliveira,Ledy Horto Santos; Santos,Larissa Silva; Silva,Carolina Oliveira; Augusto,Everton Faccini; Neves,Felipe Piedade Gonçalves.
Abstract Human papillomavirus (HPV) has been found in several regions of the body, including the oral cavity. Recently, this virus has been associated with oropharyngeal cancer, but little is known about HPV transmission to the oral cavity. We carried out a study to investigate concurrent oral and cervical infections in 76 asymptomatic women attending a healthcare program. Demographic and behavior data were obtained through a structured questionnaire. Oral and cervical mucosa scrapings were collected and stored for DNA extraction. HPV DNA amplification was performed by polymerase chain reaction assay (PCR) using both primers My09/My11 and FAP59/64, followed by HPV typing with restriction fragment length polymorphism analysis (RFLP) and sequencing. The data...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HPV; Oral infection; Transmission.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100088

Papular-purpuric "gloves and socks" syndrome caused by parvovirus B19 infection in Brazil: a case report
Provedor de dados: 55
Autores: Toyoshima,Marcos Tadashi Kakitani; Keller,Lilian Walsh; Barbosa,Maria Luisa; Durigon,Edison Luiz.
Papular-purpuric "gloves and socks" syndrome (PPGSS) is a novel, rare, self-limiting dermatosis caused by human parvovirus B19. It consists of pruritic edema and erythema of the hands and feet in a gloves-and-socks distribution, and it is associated with oral lesions and fever. We present a case of PPGSS in a 22-year-old Brazilian woman. Clinical and laboratory evaluation, including serological tests, PCR and gene sequencing, confirmed the presence of human parvovirus B19.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dermatosis; Gloves and socks; Parvovirus B19; PCR; Sequencing.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100013

Paracoccidioidomycosis: description of two cases autochthonous in Ceará
Provedor de dados: 55
Autores: Façanha,Mônica Cardoso; Souza,Anastácio de Queiroz; Café,Vaulice Sales; Wanke,Bodo.
Paracoccidioidomycosis is endemic in most countries of Latin America. Brazil has the greatest number of cases, with no autochthonous case registered in the state of Ceará. The cases of two patients that had never gone outside the State of Ceará and lived at least some years in the municipality of Palmácia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Paracoccidioidomycosis; Ceará; Systemic mycosis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100017

Paracoccidioidomycosis: evaluation of treatment and patient profile
Provedor de dados: 55
Autores: Del Fiol,Fernando Sá; Oliveira,Sara de Jesus; Barberato-Filho,Silvio; Junqueira,Fabio Miranda; Rocha,Maria Carolina Pereira da; Toledo,Maria Inês de.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600019

Paracoccidioidomycosis in pregnancy: an atypical case report
Provedor de dados: 55
Autores: Pereira,Cláudio Maranhão; Gasparetto,Patricia Freire; Alves,Virgínia Farias; Guidi,Rafaela; Botelho,Tessa de Lucena.
Tipo: Info:eu-repo/semantics/report
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500017

Paragonimiasis: first case reported in Brazil
Provedor de dados: 55
Autores: Lemos,Antônio Carlos Moreira; Coelho,João Carlos; Matos,Eliana Dias; Montal,Guilherme; Aguiar,Fernanda; Badaró,Roberto.
The authors present a case from a 59 years old white female Brazilian patient, based in Salvador-Bahia, Brazil's northeastern side area, who experienced irritative cough and progressive dyspnea, and, after 18 months, was admitted to a hospital with respiratory insufficiency. The physical exam showed diffuse rales in both hemithoraces. Initial leukogram showed 14,400 cells/mL with 14% of eosinophils and chest X-ray showed peribronchovascular infiltrate, predominating in the lower half of the lung fields, and small opaque nodules. The high-resolution computed tomography scan of the chest (HRCT) presented compatible pattern with airways disease, especially from the small airways, with air trapping, tree sprouting images, central lobular nodules and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Paragonimiasis; Tuberculosis; Respiratory insufficiency; Bronchiolitis Brazil; Case report.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100031

Paragonimiasis in Brazil
Provedor de dados: 55
Autores: Tuon,Felipe Francisco; Amato,Valdir Sabbaga; Amato Neto,Vicente.
Tipo: Info:eu-repo/semantics/other
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100001

Parainfluenza virus as a cause of acute respiratory infection in hospitalized childrens
Provedor de dados: 55
Autores: Pecchini,Rogério; Berezin,Eitan Naaman; Souza,Maria Cândida; Vaz-de-Lima,Lourdes de Andrade; Sato,Neuza; Salgado,Maristela; Ueda,Mirthes; Passos,Saulo Duarte; Rangel,Raphael; Catebelota,Ana.
Background: Human parainfluenza viruses account for a signiﬁcant proportion of lower respiratory tract infections in children.Objective: To assess the prevalence of Human parainfluenza viruses as a cause of acute respiratory infection and to compare clinical data for this infection against those of the human respiratory syncytial virus.Methods: A prospective study in children younger than ﬁve years with acute respiratory infection was conducted. Detection of respiratory viruses in nasopharyngeal aspirate samples was performed using the indirect immunofluorescence reaction. Length of hospital stay, age, clinical history and physical exam, clinical diagnoses, and evolution (admission to Intensive Care Unit or general ward, discharge or death) were assessed....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parainfluenza; Paramyxoviridae infections; Respiratory tract infections; Respiratory virus.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400358

Parainfluenza virus infections in a tropical city: clinical and epidemiological aspects
Provedor de dados: 55
Autores: Fé,Mariana Mota Moura; Monteiro,André Jalles; Moura,Fernanda Edna Araújo.
Little information on the epidemiology and clinical characteristics of human parainfluenza virus (HPIV) infections, especially in children from tropical countries, has been published. The aim of this study was to determine the frequency of HPIV infections in children attended at a large hospital in Fortaleza in Northeast Brazil, and describe seasonal patterns, clinical and epidemiological characteristics of these infections. From January 2001 to December 2006, a total of 3070 nasopharyngeal aspirates collected from children were screened by indirect immunofluorescence for human parainfluenza viruses 1, 2, and 3 (HPIV-1, 2 and 3) and other respiratory viruses. Viral antigens were identified in 933 samples and HPIV in 117. The frequency of HPIV-3, HPIV-1 and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute respiratory infections; Parainfluenza virus; Epidemiology; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300006

Parasternum pleural-cutaneous fistula in a severely immunosuppressed HIV-positive patient
Provedor de dados: 55
Autores: Gulinelli,André; Toledo,Diogo Oliveira; Coelho-Neto,Antonio Pereira; Medeiros,Roseane Pôrto.
Pleural tuberculosis occurs in 30% of patients with tuberculosis, and the percentage of patients with tuberculosis pleural effusions is comparable to human immunodeficiency virus HIV-positive and HIV-negative individuals, although pleural tuberculosis is rare in HIV-positive patients with CD4+ counts &lt; 200 cells/mm³. Pleural tuberculosis in HIV-positive patients is likely to happen in young patients, and is more frequent in intravenous drug abusers, with more acid-fast bacilli identifiable in pleural tissue. We report a rare case of pleural tuberculosis in a severely immunosuppressed HIVpositive patient, presented as two parasternum pleural-cutaneous fistula.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pleural tuberculosis; Parasternum pleural-cutaneous fistula; Severely immunosupressed HIV-positive patient.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200013

Parkinsonism in HIV infected patients during antiretroviral therapy – data from a Brazilian tertiary hospital
Provedor de dados: 55
Autores: Dehner,Luis Filipe; Spitz,Mariana; Pereira,João Santos.
Abstract  Introduction Advances in the treatment of HIV infection in the last decades have increased life expectancy of these patients and raise the question of what kind of effect chronic infection and its treatment might exert on the behavior of age-related conditions such as neurodegenerative diseases.  Patient data We performed a retrospective analysis of patients’ records to assess the frequency of the association between HIV infection and parkinsonian symptoms in our hospital population. Among 249 records we identified four individuals with reported parkinsonian symptoms initiated after HIV diagnosis. Three of them had no other identifiable cause of secondary parkinsonism. All had symptom onset before the age of 60. Based on this study sample one...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Parkinsonism; HIV; Antiretroviral therapy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500499

Pathogen frequency and resistance patterns in Brazilian hospitals: summary of results from three years of the SENTRY antimicrobial surveillance program
Provedor de dados: 55
Autores: Sader,Helio S.; Gales,Ana C.; Pfaller,Michael A.; Mendes,Rodrigo E.; Zoccoli,Cássia; Barth,Afonso; Jones,Ronald N.
BACKGROUND: Pathogen frequency and resistance patterns may vary significantly from country to country and also in different hospitals within a country. Thus, regional surveillance programs are essential to guide empirical therapy and infection control measures. METHODS: Rank order of occurrence and antimicrobial susceptibility of pathogenic species causing bloodstream infections (BSI), lower respiratory tract infections (LRTI), wound or skin and soft tissue infections (WSSTI), and urinary tract infections (UTI) in hospitalized patients were determined by collecting consecutive isolates over a specified period of time, as part of the SENTRY Antimicrobial Resistance Surveillance Program (SENTRY). All isolates were tested by reference broth microdilution....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SENTRY; Antimicrobial resistance; Nosocomial infection; Surveillance program.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400006

Pathogenesis of hepatitis C: HCV consensus 2007
Provedor de dados: 55
Autores: Viso,Ana Tereza R.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700006

Pathogenic and opportunistic respiratory bacteria-induced apoptosis
Provedor de dados: 55
Autores: Lancellotti,Marcelo; Pereira,Rafaella Fabiana Carneiro; Cury,Gisele Gentile; Hollanda,Luciana Maria de.
Several pathogenic or opportunistic bacteria have the ability to either induce or inhibit host cell apoptosis. The capacity to modulate cell pathways that result in the induction or delay of host cell apoptosis is considered to be an important bacterial virulence mechanism. These processes could be mediated by different host cell signaling pathways that are subverted by the bacteria. Pathogens are able to activate apoptotic proteins, such as caspases, or inactivate anti-apoptotic proteins, such as NFkB and the MAPKKs, or even up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. The bacteria-induced apoptotic or anti-apoptotic processes are often related with the fact that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pathogenic bacteria; Opportunistic bacteria; Apoptosis; Bacteria induce apoptosis; Respiratory bacteria.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300014

Pathogenicity mechanisms of prokaryotic cells: an evolutionary view
Provedor de dados: 55
Autores: Sousa,Cristina Paiva de.
The success of pathogenic microbes depends on their ability to colonize host tissues and to counter host defense mechanisms. Microorganisms can produce overwhelming infection because of their relatively short generation times, and because they have evolved powerful mechanisms for generating phenotypic diversity as an efficient strategy for adapting to rapidly responding immune system defenses and the broad range of polymorphisms characteristic of different host tissues. Bacterial evolution may not be a continuous process, but more of a succession of temporally spaced major events. These events cause a non-gradual sequence of adaptations to a given environment. The pathogenicity islands may be genetically unstable elements, and many of the genes coding for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pathogenicity; Prokaryotic evolution; Genetic variation; Bacterial virulence.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100004

Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Basílio-de-Oliveira,C.A.; Aguiar,G.R.; Baldanza,M.S.; Barth,O.M.; Eyer-Silva,W.A.; Paes,M.V.
Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome. The clinical features of DHF include plasma leakage, bleeding tendency and liver involvement. We studied the histopathological features of a fatal case of dengue-3 virus infection. The patient, a 63-year old male, presented with an acute onset of severe headache, myalgia and maculopapular rash. Tissue fragments (liver, spleen, lung, heart, kidney and lymph nodes) were collected for light microscopy studies and stained by standard methods. Histopathology revealed severe tissue damage, caused by intense hemorrhage, interstitial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue virus serotype 3; Dengue hemorrhagic fever; Immunoperoxidase.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400012

Pathology and pathophysiology of pulmonary manifestations in leptospirosis
Provedor de dados: 55
Autores: Dolhnikoff,Marisa; Mauad,Thais; Bethlem,Eduardo P.; Carvalho,Carlos Roberto Ribeiro.
Leptospirosis is a re-emerging zoonosis occurring as large outbreaks throughout the world caused by Leptospira interrogans. The incidence of pulmonary involvement in leptospirosis has been reported to be increasing in the last years, affecting up to 70% of the patients. Alveolar hemorrhage presented as dyspnea and hemoptysis is the main pulmonary manifestation. The emergence of massive hemoptysis and acute respiratory distress syndrome has characterized the recent changes reported in the clinical patterns of leptospirosis. The pulmonary involvement has been emerged as a serious life threat, becoming the main cause of death due to leptospirosis in some countries. In this review we present the main clinical and pathological manifestations of pulmonary...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Pulmonary hemorrhage; Diffuse alveolar damage.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100029

Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria
Provedor de dados: 55
Autores: Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Ferreira,Michelle Valéria Dias; Rivera,Juan Gonzalo Bardarez; Gomes,Margarete do Socorro Mendonça.
Abstract  Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria.  Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41 years with uncomplicated falciparum malaria were enrolled in the study. Mefloquine was administered to patients in both age groups at a dose of 20 mg kg−1. The steady-state drug concentrations were measured by reversed-phase high performance liquid chromatography.  Results All patients had an undetectable mefloquine concentration on day 0. In adults, the plasma mefloquine concentrations ranged from 770 to 2930 ng mL−1 and the erythrocyte concentrations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Infectious disease; Parasitology; Mefloquine.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500482

Patients with severe accidental tetanus admitted to an intensive care unit in Northeastern Brazil: clinical–epidemiological profile and risk factors for mortality
Provedor de dados: 55
Autores: Nóbrega,Marcus Vinícius Dantas da; Reis,Ricardo Coelho; Aguiar,Isabel Cristina Veras; Queiroz,Timóteo Vasconcelos; Lima,Ana Claudia Feitosa; Pereira,Eanes Delgado Barros; Ferreira,Raquel Feijó de Araújo.
Abstract  Introduction Tetanus, an acute infectious disease, is highly prevalent worldwide, especially in developing countries. Due to respiratory failure and hemodynamic instability associated with dysautonomia, severe cases require intensive care, but little has been published regarding the management in the Intensive Care Unit.  Objective To draw a 10-year clinical–epidemiological profile of Intensive Care Unit patients with severe tetanus, observe their evolution in the Intensive Care Unit and identify risk factors for mortality.  Methods In this retrospective study, we used a standardized questionnaire to collect information from the records of patients with severe tetanus admitted to the intensive care unit of a referral hospital for infectious and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Severe accidental tetanus; Intensive care unit; Clinical–epidemiological tetanus; Tetanus in intensive care unit.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500457

Pattern of ethionamide susceptibility and its association with isoniazid resistance among previously treated tuberculosis patients from India
Provedor de dados: 55
Autores: Lakshmi,Rajagopalan; Kumar,Vanaja; Baskaran,Murugesan; Sundar,Syam; Rahman,Fathima; Selvakumar,Nagamaiah; Ramachandran,Ranjani.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600023

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition
Provedor de dados: 55
Autores: Barros,Eliana Nogueira Castro de; Cintra,Otavio; Rossetto,Erika; Freitas,Laís; Colindres,Romulo.
Abstract Data on the burden of disease and circulation patterns of influenza B lineages for Brazil are limited. This review aims to describe the pattern of influenza B occurrence in Brazil to have a better understanding of its epidemiology and its relevance when considering seasonal influenza vaccine composition. A review of the data including analysis of international and local surveillance data as well as information from online search of databases using Medical Subject Headings terms in conjunction with screening of abstracts from scientific events was performed. Based on international epidemiologic surveillance data, moderate levels of influenza B disease (19%; 2006–2014) were observed. Of these nine years, it was possible to compare data from three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza B; Co-circulation; Mismatch; Influenza vaccines.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100081

Patterns of influenza infections among different risk groups in Brazil
Provedor de dados: 55
Autores: Bellei,Nancy; Carraro,Emerson; Perosa,Ana; Granato,Celso.
Influenza virus infections are associated with high morbidity and mortality. Influenza activity varies worldwide, and regional detection is influenced by geographic conditions, demographic and patient-risk factors. We assessed influenza activity and patterns of seasonality during three consecutive years (2001-2003) in three risk groups in São Paulo city. Four-hundred-twelve outpatients with acute respiratory infection were subjected to epidemiological, clinical and laboratory investigations; these included community population (N=140), health-care workers (N=203), and renal-transplanted patients (N=69). Nasal wash samples were tested by direct fluorescent assay for influenza, parainfluenza, adenovirus, and respiratory syncytial virus. Overall Influenza...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza; Risk groups; Respiratory viral infection.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400005

Pediatric knowledge about acute viral hepatitis
Provedor de dados: 55
Autores: Franca,Rita; Silva,Luciana; Melo,Maria Clotildes; Cavalcante,Suzy; Lima,Bruno; Rocha,Anita; Gomes,Cristiana; Franca,Mônica.
Knowledge about hepatotropic viruses is crucial for pediatricians because of the high prevalence of viral hepatitis during childhood. The multiplicity of hepatotropic viruses, the spectrum of acute and chronic infections, and the sequels of viral hepatitis result in a need for physicians to better understand the clinical and epidemiological context of patients with viral hepatitis, as well as the importance of prevention measures for hepatitis. A descriptive cross-sectional study was made of pediatrician's knowledge about viral hepatitis, through questionnaires to 574 pediatricians, with no obligation of identification. The pediatricians were recruited among those who attended a national Congress of Pediatrics in Brasília, Brazil. Among these...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis; Pediatrics.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300006

Pediatric mortality due to nosocomial infection: a critical approach
Provedor de dados: 55
Autores: Lopes,Julia Marcia Maluf; Goulart,Eugenio Marcos Andrade; Starling,Carlos Ernesto Ferreira.
Nosocomial infection is a frequent event with potentially lethal consequences. We reviewed the literature on the predictive factors for mortality related to nosocomial infection in pediatric medicine. Electronic searches in English, Spanish and Portuguese of the PubMed/MEDLINE, LILACS and Cochrane Collaboration Databases was performed, focusing on studies that had been published from 1996 to 2006. The key words were: nosocomial infection and mortality and pediatrics/neonate/ newborn/child/infant/adolescent. The risk factors found to be associated with mortality were: nosocomial infection itself, leukemia, lymphopenia, neutropenia, corticosteroid therapy, multiple organ failure, previous antimicrobial therapy, catheter use duration, candidemia, cancer,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infection; Mortality; Prognosis; Healthcare quality; Pediatric hospital.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500013

Peginterferon alfa-2a (40KD) (PEGASYS®) plus ribavirin (COPEGUS®) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy
Provedor de dados: 55
Autores: Parise,E.; Cheinquer,H.; Crespo,D.; Meirelles,A.; Martinelli,A.; Sette,H.; Gallizi,J.; Silva,R.; Lacet,C.; Correa,E.; Cotrim,H.; Fonseca,J.; Paraná,R.; Spinelli,V.; Amorim,W.; Tatsch,F.; Pessoa,M.
Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interferon-based therapy. One-hundred-thirty-four patients with biopsy-proven chronic hepatitis C, HCV RNA positive, elevated ALT and who were either relapsers (n=37) or nonresponders (n=97) to at least 24 weeks of conventional interferon/ribavirin therapy were retreated with peginterferon alfa-2a (40KD) 180mg/qw and ribavirin 800mg bid for 48 weeks. Efficacy was assessed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Peginterferon alfa; Ribavirin; Hepatitis C; Safety; Efficacy.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100003

Peginterferon plus ribavirin and sustained virological response rate in HCV-related advanced fibrosis: a real life study
Provedor de dados: 55
Autores: Silva,Giovanni Faria; Villela-Nogueira,Cristiane A.; Brandão Mello,Carlos Eduardo; Soares,Elza Cotrim; Coelho,Henrique Sergio M.; Abrão Ferreira,Paulo Roberto; Ruiz,Fernando José Goes.
Background:Tolerance and response to antiviral HCV treatment is poor in advanced fibrosis. The aim of this study was to assess SVR rate and its predictive factors in HCV advanced fibrosis patients treated in real life with full dose PEG-IFN plus RBV and to evaluate the adverse events related to treatment.Methods:A multicentric, retrospective study was conducted at six university hospitals. METAVIR F3 and F4 HCV monoinfected patients who were treated with PEG-IFN and RBV had their data analyzed. A stepwise logistic regression analysis was performed to identify the variables independently related to SVR. Adverse events were recorded during treatment.Results:308 patients were included, 75% genotype 1 and 23% genotype 3. METAVIR F3 was present in 39% and F4 in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Advanced fibrosis; Peginterferon; Ribavirin.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100048

Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil
Provedor de dados: 55
Autores: Mendes-Corrêa,Maria Cassia Jacintho; Bittar,Roseli Saraiva Moreira; Salmito,Norma; Oiticica,Jeanne.
Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hepatitis C; Chronic; Hearing loss; Sudden; Interferon-alpha.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017

Penile herpes zoster: an unusual location for a common disease
Provedor de dados: 55
Autores: Bjekic,Milan; Markovic,Milica; Sipetic,Sandra.
Herpes zoster is a common dermatological condition which affects up to 20% of the population, most frequently involving the thoracic and facial dermatomes with sacral lesions occurring rarely and only a few reported cases of penile shingles. Case report: We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. The patients presented with grouped clusters of vesicles and erythema on the left side of penile shaft and posterior aspect of the left thigh and buttock, involving s2-s4 dermatomes. The lesions resolved quickly upon administration of oral antiviral therapy. Conclusion: Penile herpes zoster should not be overlooked in patients with unilateral vesicular rash.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Herpes zoster; Penis neuralgia; Postherpetic.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600017

Penile myiasis as a differential diagnosis for genital ulcer: a case report
Provedor de dados: 55
Autores: Passos,Mauro R.L.; Ferreira,Dennis C.; Arze,Wilma N.C.; Silva,José Carlos S.; Passos,Felipe D.L.; Curvelo,José Alexandre R.
The genital localized myiasis is a rare zooparasitic dermatosis. This case reported to a penile myiasis by Dermatobia hominis larvae in a 62 year-old man, who is a retired military official from São Gonçalo city, Rio de Janeiro state, Brazil. This patient was guided to the sexually transmitted diseases (STD) clinic from Universidade Federal Fluminense (UFF) by professionals from a urology outpatient clinic of a public hospital from Rio de Janeiro state. The exam showed a 2 cm diameter nodular lesion with a hyperemic area in the glands penis that had arisen 20 days before the exam. It evolved in a favorable way after larvae removal, through previous local anesthesia and slight pressure in lesion's base with the extraction of the larvae. Penile myiasis is...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Myiasis; Infections; Penile; Genital; Dermatosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200012

Performance of an immunoenzymatic assay for Cryptosporidium diagnosis of fecal samples
Provedor de dados: 55
Autores: Marques,Fabiana Rangel; Cardoso,Luciana Ventura; Cavasini,Carlos Eugênio; Almeida,Magali Carmem de; Bassi,Nair Aparecida; Almeida,Margarete Teresa Gottardo de; Rossit,Andréa Regina Baptista; Machado,Ricardo Luiz Dantas.
We evaluated the diagnostic performance of a Cryptosporidium immunoenzymatic assay (ELISA). Fecal samples were collected from 94 HIV-seropositive patients. All specimens were processed with a commercially-available ELISA to detect C. parvum specific coproantigen and with a modified Ziehl-Neelsen stain (ZNm) microscope exam. Overall, sensitivity of the immunoenzymatic test was 100%, with a specificity of 96%; positive and negative predictive values were 89% and 100%, respectively. The commercial ELISA and ZNm proved to be valuable diagnostic tools for Cryptosporidium infection.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Parasites; Acquired immunodeficiency syndrome; Cryptosporidium diagnosis; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100002

Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study
Provedor de dados: 55
Autores: Silva,Maria José Penna Maisonnette de Attayde; Florêncio,Gilzandra Lira Dantas; Gabiatti,José Roberto Erbolato; Amaral,Rose Luce do; Eleutério Júnior,José; Gonçalves,Ana Katherine da Silveira.
OBJECTIVE: To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality. METHODS: Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis. RESULTS: Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Perinatal mortality; Morbidity; Meta-analysis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600006

Perinatal tuberculosis: a diagnostic challenge
Provedor de dados: 55
Autores: Souza,Edna Lúcia S. de; Moreira,Lícia Maria O.; Silva,Márcio Fernando.
Despite the high prevalence of tuberculosis in adults and children, the congenital and perinatal forms of tuberculosis are rare. In Brazil, there has been only one published case of congenital tuberculosis and two cases of the perinatal form of this disease. We report a case of perinatal tuberculosis presenting with pneumonia. Alcohol-acid-resistant bacilli were found in the gastric lavage. Diagnosis of this disease presentation requires a high index of suspicion.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital tuberculosis; Perinatal tuberculosis; Tuberculosis; Pneumonia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300012

Peritonitis due to Penicillium and Enterobacter in a patient receiving continuous ambulatory peritoneal dialysis
Provedor de dados: 55
Autores: Böhlke,Maristela; Souza,Person Antunes de; Menezes,Adriane Maria Delgado; Roth,Juliana Martino; Kramer,Luiz Roberto.
Infectious peritonitis is a common complication of continuous ambulatory peritoneal dialysis (CAPD). Polymicrobial peritonitis accounts for about 8% of the peritonitis episodes and involves fungi in 9% to 33% of cases. We report the known first case of polymicrobial peritonitis in which Penicillium sp. was one of the organisms cultured and the ninth case of Penicillium peritonitis in CAPD.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Peritonitis; Penicillium; Peritoneal dialysis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100035

Pertussis: a re-emerging or under diagnosed infectious disease?
Provedor de dados: 55
Autores: Cantarelli,Vlademir V.; Hoffmann,Elias R.; Fitarelli,Douglas B.; Comerlato,Liriane; Baungarten,Cláudio C.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300016

Pertussis in the central-west region of Brazil: one decade study
Provedor de dados: 55
Autores: Druzian,Angelita Fernandes; Brustoloni,Yvone Maia; Oliveira,Sandra Maria do Valle Leone; Matos,Vanessa Terezinha Gubert de; Negri,Adriana Carla Garcia; Pinto,Clarice Souza; Asato,Silvia; Urias,Cirlene dos Santos Gonçalves; Paniago,Anamaria Mello Miranda.
In many parts of the world, numerous outbreaks of pertussis have been described despite high vaccination coverage. In this article we report the epidemiological characteristics of pertussis in Brazil using a Surveillance Worksheet. Secondary data of pertussis case investigations reported from January 1999 to December 2008 recorded in the Information System for Notifiable Diseases (SINAN) and the Central Laboratory for Public Health (LACEN-MS) were utilized. The total of 561 suspected cases were reported and 238 (42.4%) of these were confirmed, mainly in children under six months (61.8%) and with incomplete immunization (56.3%). Two outbreaks were detected. Mortality rate ranged from 2.56% to 11.11%. The occurrence of outbreaks and the poor performance of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Whooping cough; Pertussis; Epidemiology; Bordetella pertussis; Outbreak investigation.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200177

Pertussis may be the cause of prolonged cough in adolescents and adults in the interepidemic period
Provedor de dados: 55
Autores: Pimentel,Analíria Moraes; Baptista,Paulo Neves; Ximenes,Ricardo Arraes de Alencar; Rodrigues,Laura Cunha; Magalhães,Vera; Silva,Andrea Rosane Sousa; Souza,Nadjla Ferreira; Matos,Deize Gomes Cavalcanti de; Pessoa,Ana Kelly Lins.
Objective:This study was aimed to evaluate the prevalence of pertussis in adolescents and adults with cough lasting more than 14 days and less than 30 days.Methods:This is a prospective observational study in interepidemic period of pertusis. Ten public health outpatient clinics in the city of Recife, Brazil, were randomly selected for the study. The study population consisted of individuals aged 10 years and over with cough that had lasted between 14 and 30 days. Nasopharyngeal swabs were collected for culture and PCR in order to identify Bordetella pertussis. We adopted the Centers for Disease Control and Prevention in the US (CDC) deﬁnition of cases of pertussis.Results:A total of 192 individuals were identiﬁed as suspected cases. Their mean age was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pertussis (whooping cough); Prolonged cough; Adolescents and adults; Prevalence.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100043

Phagocytosis and killing of epidemic methicillin-resistant Staphylococcus aureus by human neutrophils and monocytes
Provedor de dados: 55
Autores: Salgado,M.M.; Pignatari,A.C.C.; Bellinati-Pires,R.
Staphylococcus aureus is a pathogen that has been associated with nosocomial infections since the preantibiotic era. Since the introduction of antibiotics in medical practice in the 1940 s, methicillin-resistant S. aureus (MRSA) strains have been emerging in various parts of the world. In view of the important role of the phagocytic system in the defense against this bacteria, we decided to study phagocytosis by neutrophils and monocytes of an epidemic MRSA strain in São Paulo, Brazil, in comparison with methicillin-sensitive strains. Complement system opsonins are fundamental for efficient ingestion of the resistant and sensitive strains by both types of phagocytes. We found no association of the opsonic requirement of the MRSA strain with the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Human phagocytes; Phagocytosis; Epidemic methicillin-resistant.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100005

Pharmacodynamic assessment of Amoxicillin-Sulbactam against Acinetobacter baumannii: searching the optimal dose and infusion time through a human ex-vivo model
Provedor de dados: 55
Autores: Bantar,Carlos; Canigia,Liliana Fernández; Berger,María Alejandra; Soutric,Jorge L; Arenoso,Héctor J.
Amoxicillin-sulbactam (AMX-SUL) is an aminopenicillin/ß-lactamase inhibitor combination currently available in 29 countries and may be a suitable option for treating infections caused by Acinetobacter spp. Thus, we sought to search the optimal dosing strategy for this formulation through an ex vivo pharmacodynamic human model against Acinetobacter baumanniii. Four volunteers were randomized to receive alternatively a single dose AMX-SUL infused both either over 30 min or 3h at the following ratios (g/g): 1/0.5; 1/1, and 0/2. Time-kill studies were performed with the 0-, 0.5-, 2-, 4-, 6- and 8-h sera after dose against a clinical isolate of A. baumannii (sulbactam MIC, 4µg/mL). Bactericidal activity (i.e. a mean decrease &gt;3 log10 CFU/mL in the viable...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amoxicillin-sulbactam; Acinetobacter.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500006

Pharmacodynamic profiling of commonly prescribed antimicrobial drugs against Escherichia coli isolates from urinary tract
Provedor de dados: 55
Autores: Cuba,Gabriel Trova; Pignatari,Antonio Carlos Campos; Patekoski,Katya Silva; Luchesi,Lucimila Jorge; Kiffer,Carlos Roberto Veiga.
Since antimicrobial resistance among uropathogens against current first line agents has affected the management of severe urinary tract infection, we determined the likelihood that antibiotic regimens achieve bactericidal pharmacodynamic exposures using Monte Carlo simulation for five antimicrobials (ciprofloxacin, ceftriaxone, piperacillin/tazobactam, ertapenem, and meropenem) commonly prescribed as initial empirical treatment of inpatients with severe community acquired urinary tract infections. Minimum inhibitory concentration determination by Etest was performed for 205 Brazilian community urinary tract infection Escherichia coli strains from 2008 to 2012 and 74 E. coli bloodstream strains recovered from a surveillance study. Pharmacodynamic exposure...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacodynamics; Monte Carlo method; Escherichia coli; Urinary tract infection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500512

Pharmacoeconomics applied to chronic hepatitis C
Provedor de dados: 55
Autores: Tatsch,Fernando Franciosi; Sette Jr.,Hoel; Vianna,Denizar.
Life expectancy has increased over the last century as it had never been before. This is the result of a combination of many favorable variables such as level of education, improved socio-economic environment and development of medicine. However, new improvements demand heavy investment. Thus, the incorporation of medical technology became a health and economic issue. The pharmacoeconomic knowledge field is being developed to help in the analysis of medical costs and patient needs. The applies to hepatitic C, a common and chronic worldwide disease. In this article, the authors describe the rational behind this type of health economic analysis and review a hepatitis C model. Overall, in a non-Brazilian scenario, it was demonstrated that peginterferon...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacoeconomic; Hepatitis C; Peginterferon alfa-2a.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100010

Phenotypic and genotypic characterization of Rhodococcus equi isolated from sputum
Provedor de dados: 55
Autores: Silva,Paulo da; Santos,Adolfo Carlos Barreto; Sato,Daisy Nakamura; Silva,Jaqueline Otero; Medeiros,Marta Inês Cazentini; Carneiro,Ana Maria Machado; Leite,Sergio Roberto de Andrade; Leite,Clarice Queico Fujimura.
INTRODUCTION: Rhodococcus equi is an opportunistic pathogen, causing rhodococcosis, a condition that can be confused with tuberculosis. Often, without identifying M. tuberculosis, physicians initiate empiric treatment for tuberculosis. R. equi and M. tuberculosis have different susceptibility to drugs. Identification of R. equi is based on a variety of phenotypic, chromatographic, and genotypic characteristics. OBJECTIVE: This study aimed to characterize bacterial isolates from sputum samples suggestive of R. equi. METHODS: The phenotypic identification included biochemical assays; thin-layer chromatography (TLC) and polymerase chain reaction (PCR) were used for genotypic identification. RESULTS: Among 78 Gram-positive and partially acid-fast bacilli...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polymerase chain reaction; Rhodococcus equi; Mycolic acids.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500001

Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil
Provedor de dados: 55
Autores: Pereira,Jussyêgles Niedja da Paz; Rabelo,Marcelle Aquino; Lima,Jailton Lobo da Costa; Neto,Armando Monteiro Bezerra; Lopes,Ana Catarina de Souza; Maciel,Maria Amélia Vieira.
Abstract  Introduction There is a mechanism of macrolide resistance in Staphylococcus spp. which also affects the lincosamides and type B streptogramins characterizing the so-called MLSB resistance, whose expression can be constitutive (cMLSB) or inducible (iMLSB) and is encoded mainly by ermA and ermC genes. The cMLSB resistance is easily detected by susceptibility testing used in the laboratory routine, but iMLSB resistance is not. Therapy with clindamycin in cases of infection with isolated iMLSB resistance may fail.  Objective To characterize the phenotypic (occurrence of cMLSB and iMLSB phenotypes) and molecular (occurrence of ermA and ermC genes) profiles of MLSB resistance of clinical isolates of susceptible and methicillin-resistant Staphylococcus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus; Clindamycin; Inducible resistance; Erm genes.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300010

Phenotypic detection and occurrence of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli at a tertiary Hospital in Trinidad &amp;amp; Tobago
Provedor de dados: 55
Autores: Akpaka,Patrick E.; Swanston,William H.
The incidence and distribution of ESBL producing microorganisms such as E. coli and K. pneumoniae have been demonstrated and varies in different health care facilities and as well as other countries This study was carried out to determine the frequency of occurrence and the antimicrobial susceptibility pattern of ESBL producing E. coli and K. pneumoniae species from clinical isolates at a tertiary hospital in Trinidad &amp;amp; Tobago. Standard microbiological procedures and automated MicroScan System was used to identify, screen for putative ESBL production and determine antimicrobial susceptibility of 1,118 clinical isolates of Enterobacteriaceae species at the microbiology laboratory of the Eric Williams Medical Science Complex, Trinidad &amp;amp;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL detection E-test methods E. coli  K. pneumoniae Antimicrobial susceptibility Trinidad &amp;amp; Tobago Tertiary hospital.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600014

Phenotypical characteristics of group B streptococcus in parturients
Provedor de dados: 55
Autores: Simoes,Jose Antonio; Alves,Valeria Moraes Neder; Fracalanzza,Sergio Eduardo Longo; Camargo,Rodrigo Pauperio Soares de; Mathias,Lenir; Milanez,Helaine Maria Besteti Pires; Brolazo,Eliane Melo.
Colonization by Group B Streptococcus (GBS) is highly prevalent among pregnant women, with prevalence rates ranging between 4% and 30%. The infection may be transmitted vertically and may result in serious neonatal consequences. In the period from November 2003 to May 2004, a cross-sectional study was carried out among 316 parturients at the Jundiaí Teaching Hospital to establish the prevalence of genital GBS colonization, to identify the factors associated with colonization and the characteristic phenotypes of these streptococci. Samples from rectal and vaginal areas were collected for selective culture in Todd-Hewitt broth. Susceptibility to 7 antimicrobial agents was tested using the antibiotic diffusion disk technique, and the isolated strains were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus agalactiae; Neonatal infections; Antimicrobial resistance; Serum type; GBS; Pregnant woman.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200019

Phylogenetic analysis of the emergence of main hepatitis C virus subtypes in São Paulo, Brazil
Provedor de dados: 55
Autores: Nishiya,Anna Shoko; Almeida-Neto,César de; Romano,Camila Malta; Alencar,Cecília Salete; Ferreira,Suzete Cleusa; Di-Lorenzo-Oliveira,Claudia; Levi,José Eduardo; Salles,Nanci Alves; Mendrone-Junior,Alfredo; Sabino,Ester Cerdeira.
ABSTRACTBACKGROUND: It is recognized that hepatitis C virus subtypes (1a, 1b, 2a, 2b, 2c and 3a) originated in Africa and Asia and spread worldwide exponentially during the Second World War (1940) through the transfusion of contaminated blood products, invasive medical and dental procedures, and intravenous drug use. The entry of hepatitis C virus subtypes into different regions occurred at distinct times, presenting exponential growth rates of larger or smaller spread. Our study estimated the growth and spread of the most prevalent subtypes currently circulating in São Paulo.METHODS:A total of 465 non-structural region 5B sequences of hepatitis C virus covering a 14-year time-span were used to reconstruct the population history and estimate the population...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Growth rate; HCV; Phylogenetic analysis; Subtypes.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500473

Physician adherence to guidelines for tuberculosis and HIV care in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Saraceni,Valeria; Pacheco,Antonio Guilherme; Golub,Jonathan E; Vellozo,Vitoria; King,Bonnie S; Cavalcante,Solange C; Eldred,Lois; Chaisson,Richard E; Durovni,Betina.
BACKGROUND: Tuberculosis is the most common opportunistic infection among HIV-infected patients in Brazil. Brazil's national policy for HIV care recommends screening for latent tuberculosis (TB) and implementing isoniazid preventive therapy (IPT). OBJECTIVES: We compared physician adherence to TB screening and other prevention and care policies among HIV primary care clinics in Rio de Janeiro City. METHODS: Data on performance of CD4 counts, viral load testing, tuberculin skin testing (TST) and IPT were abstracted from patient charts at 29 HIV clinics in Rio de Janeiro as part of the TB/HIV in Rio (THRio) study. Data on use of pneumocystis jiroveci pneumonia (PCP) prophylaxis were also abstracted from a convenience sample of 150 patient charts at 10 HIV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS-related opportunistic infections; Tuberculosis; Disease prevention; Guideline adherence.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300012

Pityriasis rosea following human papillomavirus vaccination
Provedor de dados: 55
Autores: Drago,Francesco; Ciccarese,Giulia; Rebora,Alfredo; Parodi,Aurora.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200224

Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women
Provedor de dados: 55
Autores: Cavalcante,Rejane S.; Kopelman,Benjamin I.; Costa-Carvalho,Beatriz T.
This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnant women; Malnourished; Haemophilus influenzae type b; Passive immunization; Vaccine; Antibodies; Immunoglobulin G.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100011

Plasmid-mediated extended-spectrum beta-lactamase-producing strains of Enterobacteriaceae isolated from diabetes foot infections in a Brazilian diabetic center
Provedor de dados: 55
Autores: Motta,R.N.; Oliveira,M.M.; Magalhães,P.S.F.; Dias,A.M.; Aragão,L.P.; Forti,A.C.; Carvalho,C.B.M.
We bacteriologically analyzed 156 species of Enterobacteriaceae, isolated from 138 patients with community-acquired diabetic foot ulcers, in a prospective study made at a diabetic center and at the Federal University of Ceará, Brazil, from March, 2000, to November, 2001.The samples were cultured using selective media, and identification, susceptibility tests and detection of plasmid-mediated-extended-spectrum-beta-lactamase (ESBL) producing strains were made with conventional and automated methods. The most frequently occurring pathogens were K. pneumoniae (21.2%), Morganella morganii (19.9%) and E. coli (15.4%). High resistance rates were noted for ampicillin, first generation cephalosporin, trimethoprim/sulfamethoxazole, tetracycline,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ESBL-producing strains; Antimicrobial resistance; Enterobacteriaceae.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200006

Plasmodium falciparum and hepatitis B virus infection in Nigerian urban population
Provedor de dados: 55
Autores: Oyeyemi,Oyetunde; Amugo,Angela.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600666

Plasmodium vivax malaria presenting with severe thrombocytopenia
Provedor de dados: 55
Autores: Makkar,Ravinder Pal Singh; Monga,Surabhi Mukhopadhyay Amitabh; Gupta,Ajay Kr.
Plasmodium falciparum and Plasmodium vivax malaria are endemic infections in India and are commonly associated with mild hematological abnormalities. Severe thrombocytopenia is common in isolated falciparum and mixed falciparum/vivax malaria, but is very rare in isolated P.vivax infection. We hereby report a case of severe thrombocytopenia (platelet count of 8x10(9)/L) in a case of vivax malaria. This is only the second case ever reported in the literature of such profound thrombocytopenia in a case of isolated P.vivax malaria.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Plasmodium vivax; Malaria; Severe thrombocytopenia.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500008

Plesiomonas shigelloides exports a lethal cytotoxic-enterotoxin (LCE) by membrane vesicles
Provedor de dados: 55
Autores: Ludovico,Marilucia Santos; Martins,Luciano Moura; Bianco,Juares Ednaldo Romero; Andrade,Célia Guadalupe Tardelli de Jesus; Falcon,Rosabel; Joazeiro,Paulo Pinto; Gatti,Maria Silvia Viccari; Yano,Tomomasa.
ABSTRACT Plesiomonas shigelloides isolated from water in Brazil was previously described as a hemorrhagic heat-labile cytotoxic-enterotoxin producer. We purified this toxin from culture supernatants using ion metallic affinity chromatography (IMAC) followed by molecular exclusion chromatography. The pure toxin presented molecular mass of 50 kDa and isoelectric point (pI) around 6.9 by 2D electrophoresis. When injected intravenously, the purified cytotoxic-enterotoxin induced also severe spasms followed by sudden death of mice. Hence, we entitled it as lethal cytotoxic-enterotoxin (LCE). The presence of membrane vesicles (MVs) on cell surfaces of P. shigelloides was observed by scan electron microscopy (SEM). From these MVs the LCE toxin was extracted and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lethal cytotoxic enterotoxin (LCE); Membrane vesicles (MVs); Plesiomonas shigelloides; Toxin transportation; Virulence factors.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600546

Pleuritis caused by Acremonium strictum in a patient with metastatic testicular teratocarcinoma
Provedor de dados: 55
Autores: Virgilio,Edoardo; Mercantini,Paolo; Samra,Sara Abu; Vitali,Marco; Cavallini,Marco.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300336

Pneumocystis carinii pneumonia, pulmonary tuberculosis and visceral leishmaniasis in an adult HIV negative patient
Provedor de dados: 55
Autores: Toledo Jr.,Antonio Carlos; Castro,Márcio Rodrigues de.
This is a case report of a 29 year old male with pneumocystis pneumonia and tuberculosis, and who was initially suspected of having HIV infection, based on risk factor analyses, but was subsequently shown to be HIV negative. The patient arrived at the hospital with fever, cough, weight loss, loss of appetite, pallor, and arthralgia. In addition, he was jaundiced and had cervical lymphadenopathy and mild heptosplenomegaly. He had interstitial infiltrates of the lung, sputum smears positive for Mycobacterium tuberculosis and Pneumocystis carinii, and stool tests were positive for Strongyloides stercoralis and Schistosoma mansoni. He was diagnosed as having AIDS, and was treated for tuberculosis, pneumocystosis, and strongyloidiasis with a good response. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumocystis carinii; Visceral leishmaniasis; Tuberculosis; HIV diagnosis; Opportunistic infections.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300008

Pneumonia severity index compared to CURB-65 in predicting the outcome of community acquired pneumonia among patients referred to an Iranian emergency
Provedor de dados: 55
Autores: Alavi-Moghaddam,Mostafa; Bakhshi,Hooman; Rezaei,Bareza; Khashayar,Patricia.
OBJECTIVE: To compare the prognostic value of the pneumonia severity index and the severity score for community-acquired pneumonia (CURB-65) in predicting mortality and the need for ICU admission of patients with community-acquired pneumonia referred to our emergency department. MATERIALS AND METHODS: This prospective study was performed on patients with community-acquired pneumonia admitted to the emergency department of Imam Hossein Medical Center, Tehran, Iran. A questionnaire with demographic information, clinical signs and symptoms, laboratory and radiographic findings was completed for each patient. The information required for calculating the pneumonia severity index and CURB-65 were extracted from the medical records. The patients' clinical outcome...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CURB-65; PSI; Community-acquired pneumonia.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200011

Polyclonal outbreak of bacteremia caused by Burkholderia cepacia complex and the presumptive role of ultrasound gel
Provedor de dados: 55
Autores: Nannini,Esteban C.; Ponessa,Adriana; Muratori,Rosa; Marchiaro,Patricia; Ballerini,Viviana; Flynn,Luis; Limansky,Adriana S.
ABSTRACTA nosocomial polyclonal outbreak associated to bacteremia caused by differentBurkholderia cepacia complex (BCC) species and clones is reported. Molecular characterization identified Burkholderia stabilis, Burkholderia contaminans, and Burkholderia ambifaria among BCC isolates obtained from patients in neonatal and adult intensive care units. BCC was also isolated from an intrinsically contaminated ultrasound gel, which constituted the presumptive BCC source. Prior BCC outbreak related to contaminated ultrasound gels have been described in the setting of transrectal prostate biopsy. Outbreak caused strains and/or clones of BCC have been reported, probably because BCC are commonly found in the natural environment; most BCC species are biofilm...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Burkholderia cepacia complex; Outbreak; Bacteremia; Polyclonal.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500543

Polymerase chain reaction as a useful and simple tool for rapid diagnosis of tuberculous meningitis in a Brazilian tertiary care hospital
Provedor de dados: 55
Autores: Dora,José Miguel; Geib,Guilherme; Chakr,Rafael; Paris,Fernanda de; Mombach,Alice Beatriz; Lutz,Larissa; Souza,Carolina Fischinger Moura de; Goldani,Luciano Z.
Meningitis is a severe and potentially fatal form of tuberculosis. The diagnostic workup involves detection of acid-fast bacilli (AFB) in the cerebrospinal fluid (CSF) by microscopy or culture, however, the difficulty in detecting the organism poses a challenge to diagnosis. The use of the polymerase chain reaction (PCR) in the diagnostic approach to Mycobacterium tuberculosis (MTB) meningitis has been reported as a fast and accurate method, with several commercial kits available. As an alternative, some institutions have been developing inexpensive in house assays. In our institution, we use an in house PCR for tuberculosis. We analyzed the performance of our PCR for the diagnosis of MTB meningitis in 148 consecutive patients, using MTB culture as gold...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculous meningitis; Diagnosis; Polymerase chain reaction; PCR; Mycobacterium tuberculosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300015

Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system
Provedor de dados: 55
Autores: Silva,Rodrigo Lopes da.
BK virus, a double-stranded DNA virus, is a member of the Polyomaviridae family which is known to infect humans. Clinical evidence of disease is mostly encountered in immunosuppressed individuals such as AIDS patients or those who undergo renal or bone marrow transplantation where complications associated with BKV infection manifest commonly as a polyomavirus nephropathy or hemorrhagic cystitis, respectively. Recent evidence suggests that in addition to the JC virus (the other member of the same family known to be strongly neurotropic and responsible for the progressive multifocal leukoencephalopathy), BK virus can infect and cause clinically relevant disease in the human central nervous system. In this mini-review, an analysis of the literature is made. A...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: BK virus; Bone marrow transplantation; AIDS-related opportunistic infections.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300017

Polyomavirus infection in renal allograft
Provedor de dados: 55
Autores: Araújo,Stanley de Almeida; Honorato-Sampaio,Kinulpe; Fernandes Júnior,Ladislau José.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600016

Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors
Provedor de dados: 55
Autores: Haghighi,Malihe Fathi; Seyyedi,Noorossadat; Farhadi,Ali; Zare,Farahnaz; Kasraian,Leila; Dehbidi,Gholam Reza Refiei; Ranjbaran,Reza; Behzad-Behbahani,Abbas.
ABSTRACT  Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors.  Methods: The study included 250 healthy blood donors. Five-milliliter blood was drawn into sterile EDTA tubes and PBMCs were isolated from whole blood. The isolated PBMCs were counted and stored at −70 °C for future investigation. DNA was extracted and subjected to simple, sensitive and specific semi-nested PCR as well as QPCR using both general and specific primers for different assays.  Results: Of 250 blood samples, 66 (26.4%) were positive for BKV DNA (146-34,514 copies/106 cells). JC DNA was found in 45 (18%) blood samples (65-21,250 copies/106 cells). Co-infection with these viruses...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood donors; Leukocytes; Mononuclear; Polyomavirus; Real-time polymerase chain reaction.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100022

Poor response to tuberculosis treatment with regimens without rifampicin in immunosuppressed AIDS patients
Provedor de dados: 55
Autores: O'Donnel,M.M.; Souza Carvalho,S.; Gadelha,A.J.; Morgado,M.G.; Galhardo,M.C.G.; Lourenço,M.C.; Rolla,V.C.
A prospective study was conducted on 79 advanced immunosuppressed AIDS patients from 1997 to 1999, during which nine cases of tuberculosis (TB) were diagnosed. The main clinical and laboratory characteristics and the response to TB treatment were reviewed. The clinical manifestations of TB were: pulmonary (six cases), extrapulmonary (two cases) and disseminated (one case). These patients were being treated with highly active antiretroviral treatment (HAART) and were not responding. In three cases an optional regimen without rifampicin (RMP) was indicated to maintain HAART during TB treatment. A clinical response to TB treatment (disappearance of fever) was observed in 6/9 patients during a mean of 73 days (SD = 96). The three unresponsive patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Immunosuppression; Rifampicin; Tuberculosis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600001

Posaconazole as rescue therapy in African histoplasmosis
Provedor de dados: 55
Autores: Gonçalves,Daniel; Ferraz,Catarina; Vaz,Luisa.
Posaconazole Histoplasmosis Salvage therapy African histoplasmosis is a granulomatous mycosis caused by Histoplasma capsulatum var. duboisii. Treatment is usually extrapolated from guidelines for classical histoplasmosis, and includes 2-4 weeks of amphotericin B followed by a step-down maintenance therapy with itraconazole. Pediatric usage of posaconazole, an oral second-generation azole, remains off-label, but recent surveys show that it is safe and well tolerated in children. We report a case of disseminated African histoplasmosis in a 12-year-old boy from Guinea-Bissau. Therapy with amphotericin B and itraconazole led to a progressive clinical deterioration. A dramatic and lasting improvement was observed using posaconazole. He completed 12 months of...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Posaconazole; Histoplasmosis; Salvage therapy.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100018

Positive measles serology and new onset of type 1 diabetes presented with bilateral facial paralysis: a case report
Provedor de dados: 55
Autores: Onal,Eda Demir; Polat,Burcak; Balkan,Fevzi; Kaya,Gulfem; Ersoy,Reyhan; Çakır,Bekir; Deniz,Orhan.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300019

Positron emission tomography/computed tomography in cases with tuberculosis mimicking lung cancer
Provedor de dados: 55
Autores: Boyaci,Hasim; Basyigit,Ilknur; Baris,Serap Argun.
Tipo: Info:eu-repo/semantics/report
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200025

Post-kala-azar dermal leishmaniasis associated with AIDS
Provedor de dados: 55
Autores: Bittencourt,Achiléa; Silva,Nancy; Straatmann,Andréa; Nunes,Victor Luiz Correia; Follador,Ivonise; Badaró,Roberto.
Post-kala-azar dermal leishmaniasis (PKDL) is rarely reported in South America. In spite of the fact that there are many reports about the association of visceral leishmaniasis and AIDS, PKDL is very uncommon in HIV-positive patients, and so far only four cases have been documented in the literature. We present another case with unusual clinicopathological aspects. The patient, a 28-year-old male, from Salvador, Bahia (an endemic area) presented with clinical manifestations of visceral leishmaniasis three years after the diagnosis of AIDS. During treatment for visceral leishmaniasis he developed disseminated miliary papules. Microscopically, the skin biopsy showed a "saw-tooth" pattern with a lichenoid mononuclear infiltrate simulating lichen planus. The...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Visceral leishmaniasis; Post-kala-azar dermal leishmaniasis; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600008

Post-kala-azar dermal leishmaniasis associated with AIDS
Provedor de dados: 55
Autores: Bittencourt,Achiléa; Silva,Nancy; Straatmann,Andréa; Nunes,Victor Luiz Correia; Follador,Ivonise; Badaró,Roberto.
Post-kala-azar dermal leishmaniasis (PKDL) is rarely reported in South America. In spite of the fact that there are many reports about the association of visceral leishmaniasis and AIDS, PKDL is very uncommon in HIV-positive patients, and so far only four cases have been documented in the literature. We present another case with unusual clinicopathological aspects. The patient, a 28-year-old male, from Salvador, Bahia (an endemic area) presented with clinical manifestations of visceral leishmaniasis three years after the diagnosis of AIDS. During treatment for visceral leishmaniasis he developed disseminated miliary papules. Microscopically, the skin biopsy showed a "saw-tooth" pattern with a lichenoid mononuclear infiltrate simulating lichen planus. The...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Visceral leishmaniasis; Post-kala-azar dermal leishmaniasis; AIDS.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300009

Postnatal acquired toxoplasmosis patients in an infectious diseases reference center
Provedor de dados: 55
Autores: Silva,Cassius Schnell Palhano; Neves,Elizabeth de Souza; Benchimol,Eliezer Israel; Moraes,Danielle Ribeiro de.
Infection caused by Toxoplasma gondii, toxoplasmosis, is one of the most frequent zoonoses in the world; it normally affects both genders equally. Humans are one of several possible intermediate hosts, and the disease is oligosymptomatic in most cases. Vertical transmission is an important cause of fetal malformation and sequels in newborns. Approximately 10% of postnatal cases present multiple manifestations, ranging from low fever and mild lymphadenopathy to severe encephalitis. In moderate cases, lesions such as retinochoroiditis may emerge during acute infection or even years later. We analyzed 313 cases of toxoplasmosis from 1992 to 2004, including 261 acute cases. Most patients were women (68.1%), and 39% of these were pregnant. Among acute infection...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Toxoplasma gondii; Survey; Clinical presentation; Retinochoroiditis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500016

Pott abscess mimicking aortic aneurysm in chest X-ray
Provedor de dados: 55
Autores: Akkoyunlu,Yasemin; Aslan,Turan; Akkoyunlu,Muhammed Emin.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100019

Prediction of bacterial meningitis based on cerebrospinal fluid pleocytosis in children
Provedor de dados: 55
Autores: Águeda,Sofia; Campos,Teresa; Maia,Ana.
Children with cerebrospinal fluid pleocytosis are frequently treated with parenteral antibiotics, but only a few have bacterial meningitis. Although some clinical prediction rules, such as bacterial meningitis score, are of well-known value, the cerebrospinal fluid white blood cells count can be the initial available information. Our aim was to establish a cutoff point of cerebrospinal fluid white blood cell count that could distinguish bacterial from viral and aseptic meningitis. A retrospective study of children aged 29 days to 17 years who were admitted between January 1st and December 31th, 2009, with cerebrospinal fluid pleocytosis (white blood cell &amp;gt; 7 µL-1) was conducted. The cases of traumatic lumbar puncture and of antibiotic treatment...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pleocytosis; Bacterial meningitis; Cutoff point.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400003

Prediction of brain atrophy using three drug scores in neuroasymptomatic HIV-infected patients with controlled viremia
Provedor de dados: 55
Autores: Novakovic,Marko; Turkulov,Vesna; Maric,Daniela; Kozic,Dusko; Rajkovic,Uros; Bjelan,Mladen; Lucic,Milos; Brkic,Snezana.
ABSTRACTBACKGROUND: Despite potent antiretroviral therapy, HIV still causes brain damage. Better penetration into the CNS and efficient elimination of monocyte/macrophages reservoirs are two main characteristics of an antiretroviral drug that could prevent brain damage. The aim of our study was to assess efficacy of three antiretroviral drug scores to predict brain atrophy in HIV-infected patients.METHODS:A cross sectional study consisting of 56 HIV-infected patients with controlled viremia, who had no clinically evident neurocognitive impairment. All patients had MRI of the head. A typical T2 transversal slice was analyzed and ventricles-brain ratio (VBr) as an overall brain atrophy index was calculated. Three antiretroviral drug scores were used and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CPE; Monocyte efficacy score; Brain atrophy; HAART; HIV.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500503

Predictive model for the diagnosis of tuberculous pleural effusion
Provedor de dados: 55
Autores: Neves,Denise Duprat; Dias,Ricardo Marques; Cunha,Antônio José Ledo A. da.
This study developed a predictive model to identify pleural tuberculosis. A consecutive cases study of patients investigating the cause of pleural effusion, in an area of high prevalence of tuberculosis (Rio de Janeiro, Brazil). Clinical and laboratory variables were compared among patients with tuberculosis (TB) and without tuberculosis (NTB), individually and using logistic regression. The performance was described as diagnostic accuracy, compared to a gold standard in a masked way. We have studied 104 TB patients, 41 with malignant, 29 transudates, 28 parapneumonic, 13 with miscellaneous diseases. After identification of individual discrimination power aided by clinical, radiological and laboratory variables, the following ones were included in a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sensitivity and specificity; Tuberculosis; Pleural effusions; Predictive model; Diagnosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100019

Predictors of 14-day mortality in patients with bloodstream infections caused by Enterobacteriaceae strains: a mathematical PK/PD analysis
Provedor de dados: 55
Autores: Callefi,Luciana Azevedo; Medeiros,Eduardo A.; Furtado,Guilherme Henrique Campos.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200021

Predictors of 7- and 30-day mortality in pediatric intensive care unit patients with cancer and hematologic malignancy infected with Gram-negative bacteria
Provedor de dados: 55
Autores: Costa,Patrícia de Oliveira; Atta,Elias Hallack; Silva,André Ricardo Araujo da.
Background:Infection with Gram-negative bacteria is associated with increased morbidity and mortality. The aim of this study was to evaluate the predictors of 7- and 30-day mortality in pediatric patients in an intensive care unit with cancer and/or hematologic diseases and Gram-negative bacteria infection.Methods:Data were collected relating to all episodes of Gram-negative bacteria infection that occurred in a pediatric intensive care unit between January 2009 and December 2012, and these cases were divided into two groups: those who were deceased seven and 30 days after the date of a positive culture and those who survived the same time frames. Variables of interest included age, gender, presence of solid tumor or hematologic disease, cancer status,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cancer; Pediatric intensive care unit; Infection with Gram-negative bacteria; Mortality.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600591

Predictors of HBeAg seroconversion after long-term nucleos(t)ide analogues treatment for chronic hepatitis B: a multicenter study in real clinical setting
Provedor de dados: 55
Autores: Yu,Weiyan; Wang,Yadong; Shen,Chuan; Ji,Ru; Zhang,Li; Zhao,Xin; Su,Miao; Zhang,Ying; He,Wenyan; Cao,Jianguo; Hao,Yanshuang; Chen,Shengpeng; Zhao,Caiyan.
ABSTRACT  Aims: To evaluate the HBeAg seroconversion rate in real clinical setting and explore its predictors in long-term nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B (CHB).  Methods: 251 patients were recruited from January 2001 to September 2009 in four hospitals in Hebei province, China, for this retrospective study. Clinical and laboratory data before and after treatment with lamivudine (LAM, 100 mg daily), adefovir (ADV, 10 mg daily), telbivudine (LDT, 600 mg daily), entecavir (ETV, 0.5 mg daily), and LAM/ADV combination were compared among three groups according to treatment outcomes: synchronous HBeAg loss and HBeAg seroconversion, anti-HBe development after treatment, and no anti-HBe. Adherence was also evaluated.  Results: In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Hepatitis B and antigens; Nucleos(t)ide analogue; Adherence.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300213

Predictors of mortality in multidrug-resistant tuberculosis patients from Brazilian reference centers, 2005 to 2012
Provedor de dados: 55
Autores: Gayoso,Regina; Dalcolmo,Margareth; Braga,José Ueleres; Barreira,Draurio.
ABSTRACT  Objectives To determine the main predictors of death in multidrug-resistant (MDRTB) patients from Brazil.  Design Retrospective cohort study, a survival analysis of patients treated between 2005 and 2012.  Results Of 3802 individuals included in study, 64.7% were men, mean age was 39 (1-93) years, and 70.3% had bilateral pulmonary disease. Prevalence of human immunodeficiency virus (HIV) was 8.3%. There were 479 (12.6%) deaths. Median survival time was 1452 days (4 years). Factors associated with increased risk of death were age greater than or equal to 60 years (hazard rate [HR] = 1.6, confidence interval [CI] = 1.15-2.2), HIV co-infection (HR = 1.46; CI = 1.05-1.96), XDR resistance pattern (HR = 1.74, CI = 1.05-2.9), beginning of treatment...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Survival; Tuberculosis multidrug-resistant; Tuberculosis; Death.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400305

Predictors of undetectable plasma viral load in HIV-positive adults receiving antiretroviral therapy in Southern Brazil
Provedor de dados: 55
Autores: Silveira,Marysabel Pinto Telis; Draschler,Maria de Lourdes; Leite,José Carlos de Carvalho; Pinheiro,Cezar Arthur Tavares; Silveira,Vera Lúcia da.
Factors associated with undetectable viral load (&lt;80 copies/ml) were investigated among non-pregnant adults in antiretroviral treatment in a specialized service for HIV/AIDS in Southern Brazil. Use of antiretrovirals was investigated in two interviews (one month interval). Clinical data were collected from the clinical records; viral load previous to adherence measurement was defined the viral load previous to the first interview; the final viral load, the viral load subsequent to the second interview (interval between measures approximately 6 months). Undetectable final viral load occurred in 48% of the patients and was positively associated with levels of treatment adherence (p&lt;0.001), being 19% for less than 60% of adherence and about 60% for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Adherence; Viral load; Predictors; Risk factors.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400003

Predominance of Leishmania major and rare occurrence of Leishmania tropica with haplotype variability at the center of Iran
Provedor de dados: 55
Autores: Zahirnia,Amir Hossein; Bordbar,Ali; Ebrahimi,Sahar; Spotin,Adel; Mohammadi,Somayeh; Ghafari,Seyedeh Maryam; Ahmadvand,Setareh; Jabbari,Negar; Esmaeili Rastaghi,Ahmad Reza; Parvizi,Parviz.
ABSTRACT  Background Leishmania major is a causative agent of zoonotic cutaneous leishmaniasis in the center of Iran, Abarkouh district. Molecular characterization and precise incrimination of Leishmania species was carried out to perform controlling measurements and to design treatment programs for zoonotic cutaneous leishmaniasis.  Methods All smears isolated from ulcers of suspected patients were examined under a light microscope and graded for amastigotes frequency. Extraction of DNA, PCR, RFLP and sequencing of ITS-rDNA genotype were done to increase the efficacy of Leishmania parasites identification at their species-specific level and to detect any Leishmania infections within.  Results Humans were found to be infected with L. major with high...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmaniasis; Leishmania major; Leishmania tropica; Nuclear gene; Iran.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400278

Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
Provedor de dados: 55
Autores: Lundberg,Per; Andersson,Rune; Machado,Elizabeth S.; Costa,Tomaz Pinheiro da; Hofer,Cristina Barroso.
ABSTRACT  Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women.  Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil.  Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group.  Results: Thirty-two pregnancies occurred in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Perinatal HIV; Pregnancy; Mother-to-child transmission; Combined antiretroviral treatment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412

Preliminary evaluation of adherence on abiotic and cellular surfaces of Acinetobacter baumannii strains isolated from catheter tips
Provedor de dados: 55
Autores: Costa,Gislaine Franco de Moura; Tognim,Maria Cristina Bronharo; Cardoso,Celso Luíz; Carrara-Marrone,Floristher Elaine; Garcia,Lourdes Botelho.
The cell surface hydrophobicity and adhesion to abiotic and cellular surfaces was tested in five clinical strains of Acinetobacter baumannii isolated from catheter tips. Biochemical and molecular characteristics of these strains were also studied. Hydrophobicity was characterized by a test for affinity to xylene. Adhesion to abiotic surfaces (polystyrene, formica, latex and glass) was evaluated in Petri plates using the stamp technique. Buccal epithelial cells were used for tests of adhesion to cellular surfaces. Adhesion to the catheter was evaluated by repeatedly rinsing the catheters and rolling them over nutrient agar. Molecular typing of the strains was done by the ERIC-PCR technique. The degree of hydrophobicity of the strains varied from hydrophobic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Hydrophobicity; Adherence.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500009

Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men
Provedor de dados: 55
Autores: Machado,Ana Paula; Almeida,Flávia Gatto de; Bonin,Camila Mareti; Prata,Thiago Theodoro Martins; Ávilla,Leandro Sobrinho; Padovani,Cacilda Tezelli Junqueira; Ferreira,Alda Maria Teixeira; Fernandes,Carlos Eurico dos Santos; Tozetti,Inês Aparecida.
OBJECTIVES: The aim of this study was to identify highly oncogenic forms of human papillomavirus in the oral mucosa of asymptomatic men.METHODS: In this study, we analyzed samples of exfoliated cells from the oral cavity of 559 asymptomatic men. DNA-human papillomavirus was detected using the consensus primers PGMY09/11; viral genotyping was performed using type-specific PCR and restriction fragment length polymorphism.RESULTS: DNA-human papillomavirus was detected in 1.3% of the study participants and of those 42.8% were infected by more than one type of virus. Viral types included HPV6, 11, 89 (low oncogenic risk), and HPV52, 53 (high oncogenic risk). Increased vulnerability to human papillomavirus infection was observed in individuals aged over 26...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human papilomavírus; Men; Viral type; Oral mucosal.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300266

Preservation of cytotoxic granule production in response to mycobacterial antigens by T-lymphocytes from vertically HIV-infected Brazilian youth on effective combined antiretroviral therapy
Provedor de dados: 55
Autores: Arrym,Mauro Pedromonico; Alves,Paulo César Martins; Castelhano,Mariana Virginello; Mazzola,Taís Nitsch; Lemos,Renata Muller Banzato Pinto de; Zaccariotto,Tânia Regina; Levy,Carlos Emilio; Guimarães,Fernando; Silva,Marcos Tadeu Nolasco da.
ABSTRACT  Background: HIV infection harms adaptive cellular immunity mechanisms. Long-term virological control by combined antiretroviral therapy (cART) reduces the risk of mycobacterial infections. Thus, we aimed to study cellular responses to mycobacterial antigens in 20 HIV-infected adolescents with at least one year of virological control (HIV-RNA &lt;40 copies/mL) and 20 healthy adolescents.  Methods: We evaluated CD8 and γδ T-cell degranulation by measurement of CD107a membrane expression after stimulation with lysates from BCG (10 µg/mL) and H37RA Mycobacterium tuberculosis (Mtb, 10 µg/mL). Immune activation and antigen-presenting ability were also assessed by determination of HLA-DR, CD80, and CD86 markers.  Results: TCR γδ T-cell CD107a expression...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/Aids; BCG; Youth; Tuberculosis; Citotoxicity; Immunologic.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300151

Pressure ulcer as a reservoir of multiresistant Gram-negative bacilli: risk factors for colonization and development of bacteremia
Provedor de dados: 55
Autores: Braga,Iolanda A.; Brito,Cristiane S.; Diogo Filho,Augusto; Gontijo Filho,Paulo P.; Ribas,Rosineide M.
Abstract The purpose of this study was to identify the risk factors that predispose patients who are hospitalized with pressure ulcers (PUs) colonized by Gram-negative bacilli (GNB) to develop bacteremia. In addition, we also detected main phenotypes of resistance in infected and uninfected PUs. A prospective cohort study was conducted at the Clinical Hospital of the Federal University of Uberlândia including patients with Stage II or greater PUs, colonized or not with GNB, from August 2009 to July 2010. Infected ulcers were defined based on clinical signs and on positive evaluation of smears of wound material translated by a ratio of polymorphonuclear cells to epithelial cells ≥2:1, after Giemsa staining. A total of 60 patients with Stage II PUs were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Pressure ulcer; Gram-negative bacilli; Colonization; Bacteremia.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200171

Prevalence and antimicrobial susceptibility of respiratory pathogens in patients with cystic fibrosis
Provedor de dados: 55
Autores: Paixão,Vilma Almeida; Barros,Tânia Fraga; Mota,Clélia Maria C; Moreira,Tamy Fagundes; Santana,Maria Angélica; Reis,Joice Neves.
Respiratory infection is very common in patients suffering from cystic fibrosis (CF). However, the antimicrobial resistance rate of isolates from CF patients is not often documented. In this study, 279 respiratory specimens of 146 patients were prospectively collected from July to December 2006. Microbiological cultures and antimicrobial susceptibility tests of the most frequently isolated bacteria were performed. Sputum and oropharyngeal swabs were processed for culture. During the study period, 50% of the patients harbored Staphylococcus aureus, 35% Pseudomonas aeruginosa, 4.7% Haemophilus influenzae. Methicillin resistant S. aureus (MRSA) were detected in 8 (6%) patients; ESBL and MBL-producing P. aeruginosa were not identified in these patients. The...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cystic fibrosis; Antimicrobial resistance; Pseudomonas aeruginosa; Staphylococcus aureus.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400016

Prevalence and antimicrobial susceptibility of Salmonella serotypes in patients from Ribeirão Preto, São Paulo, Brazil, between 1985 and 1999
Provedor de dados: 55
Autores: Castro,Fabíola Attié de; Santos,Vanda Roseli dos; Martins,Carlos H. Gomes; Fernandes,Sueli A.; Zaia,José Eduardo; Martinez,Roberto.
Salmonella strains isolated from 1,138 samples representing 28,199 biological materials (stool, urine, blood and other fluids), collected between January 1985 and January 1999 at a reference University Hospital in Ribeirão Preto, São Paulo, Brazil, were studied. The most frequently detected serotypes were Salmonella enterica subspecies enterica serotype4,5,12:i:- (S. I 4,5,12:i:) (21.2%), S. agona (15.8%) and S. enteritidis (11.3%). A changing pattern of Salmonella serotypes was observed between 1985-1999. S. agona, which represented 27% of Salmonella serotypes isolated from 1985-1989, declined to 4% during the period from 1995 to 1999. S. enteritidis isolation remained below 1% until 1989; rose to 5.9% between 1990 and 1994, and increased to 32.3% between...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella; Salmonellosis; Serotypes; Epidemiology and gastroenteritis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500005

Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany
Provedor de dados: 55
Autores: Puglia,Monia; Stasi,Cristina; Da Frè,Monica; Voller,Fabio.
Abstract  Introduction Worldwide about 30% of HIV-infected patients are coinfected with HCV or HBV. The HIV/HCV coinfection is more common in individuals who have a history of drug addiction. The aims of this study were to assess the HCV and HBV prevalence in HIV-infected patients and analyze their characteristics.  Methods We considered the new HIV diagnoses notified by the regional surveillance system of Tuscany from 2009 to 2013. Descriptive analyses were conducted on the socio-demographic characteristics, routes of transmission, and reason to perform the test. In coinfected patients we assessed the risk for being late presenter (LP) or the risk of having AIDS.  Results In 5 years of surveillance a total of 1354 new HIV diagnoses were notified: 1188...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HBV; HCV; Coinfections.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400330

Prevalence and characters of Entamoeba histolytica infection in Saudi infants and children admitted with diarrhea at 2 main hospitals at south Jeddah: a re-emerging serious infection with unusual presentation
Provedor de dados: 55
Autores: Hegazi,Moustafa Abdelaal; Patel,Tabarek Ahmed; El-Deek,Basem Salama.
In this study, Entamoeba histolytica had high prevalence and unusual presentation by affecting high proportion of infants under 1 year; severe clinical manifestations, and laboratory findings that were known to be usually encountered in invasive amebiasis as significant leukocytosis for age, neutrophilic leukocytosis for age, and positive C-reactive protein were found among more than 50% of admitted Saudi infants and children with E. histolytica infection in our locality. E. histolytica can be a re-emerging serious infection when it finds favorable environmental conditions and host factors which are mainly attributed to inadequate breastfeeding in this study. This may occur in any other area of the world with the same risk factors, so we must be ready to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Entamoeba histolytica; Saudi; Infants; Children.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100006

Prevalence and factors associated with darunavir resistance mutations in multi-experienced HIV-1-infected patients failing other protease inhibitors in a referral teaching center in Brazil
Provedor de dados: 55
Autores: Vidal,Jose E; Freitas,Angela C; Song,Alice TW; Campos,Silvia V; Dalben,Mirian; Hernandez,Adrian V.
Information about resistance profile of darunavir (DRV) is scarce in Brazil. Our objectives were to estimate the prevalence of DRV resistance mutations in patients failing protease inhibitors (PI) and to identify factors associated with having more DRV resistance mutations. All HIV-infected patients failing PI-based regimens with genotyping performed between 2007 and 2008 in a referral teaching center in São Paulo, Brazil, were included. DRV-specific resistance mutations listed by December 2008 IAS-USA panel update were considered. Two Poisson regression models were constructed to assess factors related to the presence of more DRV resistance mutations. A total of 171 HIV-infected patients with available genotyping were included. The number of patients with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Highly active; HIV protease inhibitors; Acquired immunodeficiency syndrome; Brazil.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300011

Prevalence and factors associated with rectal vancomycin-resistant enterococci colonization in two intensive care units in São Paulo, Brazil
Provedor de dados: 55
Autores: Furtado,Guilherme Henrique Campos; Martins,Sinaida Teixeira; Coutinho,Ana Paula; Wey,Sérgio Barsanti; Medeiros,Eduardo Alexandrino Servolo.
Vancomycin-resistant enterococci (VRE) are important pathogens causing nosocomial infections, and there is reason for concern about their resistance and great ability to spread in hospital environments, especially intensive-care units (ICU). To determine the prevalence of rectal colonization by VRE, and the risk factors associated with their presence, rectal surveillance swabs were taken from patients under treatment in two intensive-care units (one medical and another both medical and surgical) at São Paulo Hospital, over a two-year period. Thirty-three percent of the 147 patients evaluated had VRE. The only significant variable in the logistic regression was the length of stay in the ICU.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin-resistant enterococci; Rectal colonization; Intensive care unit.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100011

Prevalence and molecular analysis of multidrug-resistant Acinetobacter baumannii in the extra-hospital environment in Mthatha, South Africa
Provedor de dados: 55
Autores: Anane A,Yaw; Apalata,Teke; Vasaikar,Sandeep; Okuthe,Grace Emily; Songca,Sandile.
ABSTRACT  Introduction: The presence of Acinetobacter baumannii outside hospitals remains unclear. This study aimed to determine the prevalence of multidrug-resistance (MDR) A. baumannii in the extra-hospital environment in Mthatha, South Africa and to investigate the frequency of carbapenemase-encoding genes.  Material and Methods: From August 2016 to July 2017 a total of 598 abattoir samples and 689 aquatic samples were collected and analyzed presumptively by cultural methods for the presence of A. baumannii using CHROMagar™ Acinetobacter medium. Species identiﬁcation was performed by autoSCAN-4 (Dade Behring Inc., IL) and confirmed by the detection of their intrinsic blaOXA-51 gene. Confirmed MDR A. baumannii isolates were screened for the presence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Carbapenemase-encoding genes; Extra-hospital; Multidrug-resistance; ISAba1; IntI1.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600371

Prevalence and risk factors for cervical intraepithelial neoplasia among HIV-infected women
Provedor de dados: 55
Autores: Teixeira,Nara Chartuni Pereira; Araújo,Angela Cristina Labanca; Correa,Christine Miranda; Lodi,Claudia Teixeira da Costa; Lima,Maria Inês Miranda; Carvalho,Nara de Oliveira; Castillo,Dora Mendez del; Melo,Victor Hugo.
OBJECTIVES: To evaluate the prevalence and the risk factors for cervical intraepithelial neoplasia (CIN) among HIV-infected women. METHODS: Cross-sectional study of 494 HIV-infected women in Brazil, between 1998 and 2008. Gynecologic exam was performed, and samples were collected for cervical cytology and for HPV DNA detection. Cervical biopsy was carried out when indicated. HPV infection, CD4 T-lymphocyte count and HIV viral load were compared with cervical histopathology. Univariate and multivariate statistical analyses were performed to evaluate the statistical association of several risk factors. RESULTS: CIN prevalence detected by histopathology was 23.4% (6% of CIN2/3 and 17.4% cases of CIN1). Multivariate analysis confirmed an independent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV DNA probes; HPV Cervical intraepithelial neoplasia Immunosuppression.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200010

Prevalence and risk factors for chronic hepatitis B in HIV patients attended at a sexually-transmitted disease clinic in Vitoria, Brazil
Provedor de dados: 55
Autores: Zago,Adriana Marchon; Machado,Thayla Ferrari; Cazarim,Flavia Lagrota; Miranda,Angélica Espinosa.
This study assessed the prevalence of and correlated factors for chronic hepatitis B infection (HBV) among HIV patients attending the Reference Center for Sexually Transmitted Infections (STI) and AIDS in Vitória, ES, Brazil. HIV patients were studied from 1993 to 2004, using information recorded in a database of the STI Clinic. Demographic data, clinical characteristics, patterns of risk behavior and test results (ELISA-HIV, IFA-HIV, HBsAg, viral load and CD4 counts) were analyzed. We analyzed 851 HIV patients. Median age was 35.0 (interquartile range 30; 42) years and median years of education was 8.0 (IQR 5; 11). The prevalence of chronic HBV was 3.8% (95% CI 2.5-5.1). Illicit drug use was reported in 185 (21.7%) cases, alcohol abuse in 80 (9.4%) cases,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HIV; Prevalence; STI clinic.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500007

Prevalence and risk factors for erectile dysfunction in HIV-infected patients in Salvador, Brazil
Provedor de dados: 55
Autores: Gomes,Tacila Veras; Brites,Carlos.
ABSTRACT  Background: Effective antiretroviral therapy (ART) has increased life expectancy for HIV patients to levels close to that observed for general population. Comorbidities are also increasing, due to ageing of such population. Erectile dysfunction (ED) has been a frequent finding in men living with HIV.  Objectives: The goals of the present study were to define the prevalence of ED and associated factors in HIV-infected men, in a referral center of Salvador city, Brazil.  Methods: HIV-infected men ≥18 years of age, receiving care at the AIDS Clinics of Complexo Hospitalar Professor Edgard Santos (C-HUPES), Universidade Federal da Bahia were consecutively included in the study until the estimated sample size (N = 134) was reached. Patients filled a...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Erectile dysfunction; AIDS; Bahia; Risk factors.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600464

Prevalence and risk factors for human immunodeficiency virus infection in pregnant women in Eastern Ghana
Provedor de dados: 55
Autores: Yoon,Hee Jung; Bonsu,George; Akoto-Ampaw,Arko; Nkrumah-Mills,Grace; Nimo,Julia J.A.; Park,Jin Kyung; Ki,Moran.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200024

Prevalence and risk factors for human papillomavirus infection among Chinese ethnic women in southern of Yunnan, China
Provedor de dados: 55
Autores: Baloch,Zulqarnain; Yasmeen,Nafeesa; Li,Yuanyue; Ma,Ke; Wu,Xiaomei; Yang,Shi-hua; Xia,Xueshan.
ABSTRACT  Background: Dai is a major Chinese ethnic minority group residing in rural areas of the southern part of Yunnan. However, no data exist on the Human Papillomavirus (HPV) prevalence and genotype distribution among Dai women.  Method: A total of 793 participants (Dai = 324, Han = 251, other ethnic = 218) were included in this study. PCR was performed to detect the HPV-positive samples, and genotyping was performed with an HPV Geno-Array.  Result: The overall HPV prevalence was very low among Dai women compared to the others. The prevalence of high-risk-HPV infections was significantly higher (p = 0.001) among other ethnic women (22.0%) than that among Han (13.1%) and Dai women (7.1%). The overall HPV, high-risk-HPV, single and multiple infection...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Prevalence; Dai; Genotypes; Rural; Urban; China.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300325

Prevalence and risk factors for Staphylococcus aureus in health care workers at a University Hospital of Recife-PE
Provedor de dados: 55
Autores: Silva,Eduardo Caetano Brandão Ferreira da; Antas,Maria das Graças C.; B. Neto,Armando Monteiro; Rabelo,Marcelle Aquino; Melo,Fábio Lopes de; Maciel,Maria Amélia Vieira.
Staphylococcus aureus is the main human pathogen that colonizes individuals in general population. The objective of the study was evaluate the epidemiological and sensitivity profile of S. aureus lineage, isolated in health care workers (HCW) of a University Hospital in Pernambuco state, Brazil. Biological samples of hands and nasal cavities were sown in agar sheep blood. Colonies under suspicion of being S. aureus were identified using Gram staining, catalase test and coagulase, mannitol-salty agar fermentation and DNAse agar. The resistance to mupirocin was analyzed through the Kirby Bauer technique. In relation to methicillin and vancomycin the determination was by the minimum inhibitory concentration method (E-test). From the 202 HCW evaluated, 52 were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Colonization; Health staff.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600012

Prevalence and risk factors of mild chronic renal failure in HIV-infected patients: influence of female gender and antiretroviral therapy
Provedor de dados: 55
Autores: Cristelli,Marina Pontello; Trullàs,Joan Carles; Cofán,Federico; Rico,Naira; Manzardo,Christian; Ambrosioni,Juan; Bedini,Josep Lluis; Moreno,Asunción; Diekmann,Fritz; Miro,Jose Maria.
ABSTRACT  Background In people living with HIV, much is known about chronic kidney disease, defined as a glomerular filtration rate under 60 mL/min. However, there is scarce data about prevalence and risk factors for milder impairment (60-89 mL/min).  Objective The present study aims to assess the influence of sex, antiretroviral therapy, and classical risk factors on the occurrence of mild decreased renal function in a large Spanish cohort of HIV-infected patients.  Methods Cross-sectional, single center study, including all adult HIV-1-infected patients under antiretroviral treatment with at least two serum creatinine measures during 2014, describing the occurrence of and the risk factors for mildly decreased renal function (eGFR by CKD-EPI creatinine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-infection; Antiretroviral drugs; Chronic kidney disease; Glomerular filtration rate estimates.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300193

Prevalence and risk factors of osteopenia/osteoporosis in Turkish HIV/AIDS patients
Provedor de dados: 55
Autores: Aydın,Ozlem Altuntas; Karaosmanoglu,Hayat Kumbasar; Karahasanoglu,Rıdvan; Tahmaz,Meryem; Nazlıcan,Ozcan.
BACKGROUND: Recent studies showed a high frequency of low bone mineral density (BMD) in HIV-infected patients and no reports have been issued in Turkey. Our aim was to evaluate BMD and risk factors for osteopenia/osteoporosis in HIV-infected patients that attended an outpatient clinic in Istanbul, Turkey. METHOD: In order to determine the prevalence of BMD, 126 HIV-infected patients had been studied with dual energy X-ray absorptiometry (DEXA). The association between BMD and age, gender, body mass index (BMI), habits, 25(OH)vitamin D, HIV RNA, CD4 lymphocyte nadir, using and duration of highly active antiretroviral treatment (HAART) were investigated by using multivariate analysis. RESULTS: Median age was 40.1 years (range, 20-70); 84% were male; 35.7%...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Osteopenia/osteoporosis; HIV/AIDS; Prevalence Risk factors.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600014

Prevalence of antibodies to Borrelia burgdorferi sensu stricto in humans from a Cuban village
Provedor de dados: 55
Autores: Rodríguez,Islay; Fernández,Carmen; Sánchez,Lizet; Martínez,Bárbara; Siegrist,Hans H.; Lienhard,Reto.
Lyme disease has not been officially reported in Cuba. However, clinical cases have been serologically reported. Seroprevalence survey of Borrelia burgdorferi sensu stricto antibodies in humans in the country has not been conducted. OBJECTIVE: To estimate the prevalence of borrelial antibodies in inhabitants of a village with historically high level of tick infestation. METHODS: Serum specimens from 247 persons randomly selected from the population of the village were examined by IgG Western blot using B31 strain for estimating the prevalence of antibodies profile. RESULTS: A seroprevalence value interval (95% CI) of 0.6%-7.2% was estimated for the studied population. The prevalent borrelial protein bands on immunoblots were 41, 72, 90/93, 34, 47, 60, 58,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Borrelia burgdorferi; Prevalence; Lyme disease; Antibodies.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100015

Prevalence of anxiety, depression and quality of life in HTLV-1 infected patients
Provedor de dados: 55
Autores: Gascón,Maria Rita Polo; Capitão,Claudio Garcia; Casseb,Jorge; Nogueira-Martins,Maria Cezira Fantini; Smid,Jerusa; Oliveira,Augusto César Penalva de.
The HAM/TSP caused by HTLV-1 infection usually affects patients to disabling states, and sometimes can lead them to paraplegia presenting symptoms of depression and anxiety, impacting on quality of life. Objective: The purpose of this study was to evaluate the frequency of depression and anxiety and its impact on quality of life in HTLV-1-infected TSP/HAM patients. Material and Methods: This was a cross-sectional study including 67 asymptomatic (control group) and 63 with TSP/HAM subjects. The instruments used were a demographic questionnaire, scales for anxiety and depression diagnosis (BDI and BAI), questionnaire for the assessment of Quality of Life of the World Health Organization (WHOQOL-Brief) and neurological scale to measure the disability level...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anxiety; Depression; Quality of life; Human T-lymphotropic virus 1.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600013

Prevalence of carbapenem resistant Pseudomonas aeruginosa and Acinetobacter baumannii in high complexity hospital
Provedor de dados: 55
Autores: Baumgart,Ana Milda Karsten; Molinari,Marcelo André; Silveira,Alessandro Conrado de Oliveira.
Pseudomonas aeruginosa and Acinetobacter baumannii are Gram-negative bacilli that in the last decades have become prevalent agents of hospital infection due to high antimicrobial resistance developed by these microorganisms. The present study is a retrospective analysis of all positive cultures for these microorganisms in the period of January 2004 to December 2008. Resistance levels of A. baumannii and P. aeruginosa to carbapenems was high and showed a trend to increase during the period of study. In recent years the increasing incidence and resistance levels of A. baumannii and P. aeruginosa to the antimicrobials used for their treatment in the hospital setting underscores the relevance of infections caused by these bacteria. The selective pressure...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Pseudomonas aeruginosa; Drug resistance; Carbapenems; Hospital infection control program.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500002

Prevalence of cervical Chlamydia trachomatis infection in sexually active adolescents from Salvador, Brazil
Provedor de dados: 55
Autores: Machado,Márcia Sacramento Cunha; Silva,Bruno Fernando Borges da Costa e; Gomes,Igor Logetto Caetité; Santana,Iuri Usêda; Grassi,Maria Fernanda Rios.
The incidence of sexually transmitted diseases among adolescents is increasing worldwide. Genital Chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in young women, and undetected disease is highly associated with long-term complications in women. Our goal was to determine the prevalence of cervical Chlamydia trachomatis infection in a sexually active population of female adolescents from Salvador, Brazil, and to describe their socio-demographic, behavioral, and clinical characteristics. 100 sexually active adolescents (10-19 years) were included in this study, between 2008 and 2010. Endocervical samples were obtained during gynecological examination. Inhouse polymerase chain reaction of cervical specimens was used...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chlamydia trachomatis; Polymerase chain reaction; Adolescent.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200015

Prevalence of Chlamydia trachomatis and Neisseria gonorrhea and associated factors among women living with Human Immunodeficiency Virus in Brazil: a multicenter study
Provedor de dados: 55
Autores: Miranda,Angelica E.; Silveira,Mariangela F.; Travassos,Ana Gabriela; Tenório,Teresinha; Val,Isabel Cristina Chulvis do; Lannoy,Leonor de; Mattos Junior,Hortensio Simões de; Carvalho,Newton Sergio de.
Abstract  Background: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) cause infections in the female genital tract, increasing susceptibility to and infectiousness of HIV. The objectives of the present study were to determine the prevalence and associated factors of CT and GC infection among HIV-infected women in Brazil.  Methods: Cross-sectional study conducted from March to December 2015, including HIV-infected women attending referral centers in nine states of Brazil, aged 18-49 years, nonpregnant. An interview was conducted including socio-demographic, epidemiological and clinical characteristics. After the interview, gynecological examination was conducted to collect cervical cytology and vaginal secretion to C. trachomatis and N....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Neisseria gonorrhoeae; HIV; Women; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400402

Prevalence of community acquired infections in down syndrome children: a single center study
Provedor de dados: 55
Autores: Eldars,Waleed; Eldegla,Heba; Yahia,Sohier; Ela,Mohamed Abou; Hawas,Samia.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500022

Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis
Provedor de dados: 55
Autores: Barbi,Ludovica; Coelho,Antonio Victor Campos; Alencar,Luiz Cláudio Arraes de; Crovella,Sergio.
ABSTRACT Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Arboviruses; Zika virus; Guillain-Barré syndrome; Epidemiology; Emergent diseases.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200137

Prevalence of HBV genotypes in South American immigrants affected by HBV-related chronic active hepatitis
Provedor de dados: 55
Autores: Palumbo,Emilio; Scotto,Gaetano; Faleo,Giuseppina; Cibelli,Donatella Concetta; Angarano,Gioacchino.
This study evaluated the prevalence of HBV infection in a population of South American immigrants in Italy and to determine in patients with detectable serum HBV-DNA the HBVgenotypes. Between April 2005 and April 2006 a total of 130 South American immigrants were tested for HBsAg. In HBsAg positive patients the biochemical and virological activity of infection and the possible presence of co-infections (HCV, HDV, HIV) were evaluated. In patients with detectable serum HBV DNA, the HBV genotype was determined by INNOLiPA. Among the 130 subjects tested, 14 (10.7%) resulted HBsAg positive. All were men, with a mean age of 22 years (range 19-37) and 12 (85.7 %) came from Brazil, while 2 (14.3%) came from Ecuador. All patients infected by HBV had elevated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV genotypes; Chronic hepatitis B; Immigrants; HBsAg; Viral genome.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300002

Prevalence of hepatitis B among pregnant women assisted at the public maternity hospitals of São Luís, Maranhão, Brazil
Provedor de dados: 55
Autores: Souza,Marinilde Teles; Pinho,Tainá Lima Reis de; Santos,Max Diego Cruz; Santos,Alexsandro dos; Monteiro,Vera Lúcia; Fonsêca,Lena Maria Barros; Ferreira,Pedro Antônio Muniz; Ferreira,Adalgisa de Souza Paiva.
INTRODUCTION: Hepatitis B virus (HBV) infection is an important worldwide public health problem. In Brazil, the Ministry of Health estimates that 15% of the population has had contact with HBV, and that the mean rate of chronic carriers in Northeastern Brazil is around 0.5%. OBJECTIVE: The aim of this study was to assess the prevalence of HBV markers in pregnant women receiving prenatal care at the public maternity hospitals of São Luís. Methods: Demographical and epidemiological data were collected from 541 pregnant women according to the research protocol. Blood samples were collected, and the anti-HBc test was performed first. If positive, the sample was subsequently tested for HBsAg and anti-HBs. All HBsAg and/or anti-HBc positive samples were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnant; Hepatitis B; HBV-DNA.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600003

Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil
Provedor de dados: 55
Autores: Brandão,Natália Alberto Alves; Pfrimer,Irmtraut Araci Hoffmann; Martelli,Celina Maria Turchi; Turchi,Marília Dalva.
This study aimed to estimate the prevalence of infection by the hepatitis B virus (HBV) and hepatitis C virus (HCV) in people infected by the human immunodeﬁciency virus (HIV) and analyze sociodemographic and behavioral factors associated with such co-infection. A cross-section study was performed in 495 individuals treated at a public center in the city of Goiânia. Participants were interviewed and blood collected for evaluation of serological and molecular markers for HBV and HCV. The rate of exposure to HBV was 33.5% (95% CI 29.4-37.9). Nineteen patients (3.8%) were diagnosed as HBV carriers, of whom 68.4% were HBV DNA positive. The prevalence of anti-HCV was 9.7% (95% CI 7.3-12.7). Genotype 1a was identiﬁed in 72.7% of the PCR samples positive for HCV....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Hepatitis; Co-infection; Prevalence.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400426

Prevalence of hepatitis B and C virus infections among military personnel
Provedor de dados: 55
Autores: Villar,Livia M.; Ó,Kycia Maria R. do; Scalioni,Leticia P.; Cruz,Helena M.; Portilho,Moyra M.; Mendonça,Ana Carolina F.; Miguel,Juliana C.; Figueiredo,Andreza S.; Almeida,Adilson J. de; Lampe,Elisabeth.
Background: Data regarding Hepatitis B and C viruses (HBV and HCV) prevalence among military personnel in Brazil are lacking, but the work-related risk of exposure can be high. The objective of this study was to estimate the seroprevalence of HBV and HCV and the risk factors associated to HBV exposure among Brazilian military personnel.Methods: A cross-sectional study was conducted and included 433 male military adults aged 18-25 years old working in Rio de Janeiro during October 2013. All individuals completed a questionnaire to assess their risk of exposure and provided a blood sample to HBV and HCV testing.Results: None of the participants presented HBsAg or anti-HBc IgM, 18 (4.1%) were positive for total anti-HBc, 247 (57.0%) were positive for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Hepatitis C; Prevalence; Military personnel.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300285

Prevalence of hepatitis C among dock workers
Provedor de dados: 55
Autores: Focaccia,Roberto; Moraes,Adriana Silva de; Ribeiro,Maria Luiza Alessi; Carbonari,Karla Fabiana Begosso Sampaio da Fonseca; Quevedo,Bruna de Souza.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400355

Prevalence of hepatitis C and B virus infection in patients with idiopathic dilated cardiomyopathy in Brazil: a pilot study
Provedor de dados: 55
Autores: Reis,Francisco J.F.B.; Viana,Mateus; Oliveira,Manoela; Sousa,Tiago A.; Paraná,Raimundo.
The idiopathic dilated cardiomyopathy (IDMC) is a disease of the cardiac muscle characterized by systolic dilation and/or dysfunction of one or both ventricles, symptoms of congestive heart failure and risk of early death. Several studies in animal models and in humans have supported the hypothesis of the viral infection as initial event in the immunopathogenesis of the ventricular dilation. The objective of this study was to correlate the presence of hepatitis C virus chronic infection and idiopathic dilated cardiomyopathy, comparing samples of cases with IDCM with paired controls with Chagas-type specific dilated cardiomyopathy and ischemic-type specific dilated cardiomyopathy. Only 2.9% (1/34) of IDCM patients were HCV carriers, which strongly argue...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Idiopathic dilated cardiomyopathy; Hepatitis C virus; Myocarditis; Heart failure.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300004

Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru
Provedor de dados: 55
Autores: Iwasaki,Ricardo; Galvez-Philpott,Felipe; Arias-Stella Jr.,Javier; Arias-Stella,Javier.
Background:Molecular tests allow the detection of high-risk human papillomavirus in cervical samples, playing an important role in the prevention of cervical cancer.Objectives:We performed a study to determine the prevalence of HPV 16, HPV 18 and other high-risk human papillomavirus (pool 12 genotypes) in Peruvian females from diverse urban areas using the cobas 4800 HPV test.Methods:Routine cervical samples collected in our laboratory were analyzed by cobas 4800 HPV test.Results:A total of 2247 samples from female patients aged 17–79 years were tested. high-risk human papillomavirus was positive in 775 (34.49%) samples. Of these, 641 (82.71%) were single infections and 134 (17.29%) were multiple infections. The positivity rates for HPV 16, HPV 18, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: High-risk human papillomavirus; Prevalence; Cobas 4800 HPV test.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500469

Prevalence of HIV infection in patients hospitalized for tuberculosis in Bahia, Brazil
Provedor de dados: 55
Autores: Matos,Eliana Dias; Lemos,Antônio Carlos Moreira; Bittencourt,Carolina; Mesquita,Critiane Leite; Kuhn,Patrícia Chamadoira.
HIV infection is an important risk factor for the development of tuberculosis (TB), and also affects its morbidity and mortality. This study estimated the prevalence of HIV infection in patients hospitalized for TB in Bahia (in northeastern Brazil) and to evaluate its impact on in-hospital mortality. A total of 375 patients with TB, admitted consecutively to a TB reference hospital in Salvador (Bahia, Brazil), were evaluated between July 2001 and July 2003. Anti-HIV serology was performed in all patients irrespective of clinical and/or epidemiological data suggestive of HIV infection. Death during hospitalization was the principal event-dependent variable. Mean age of patients was 41.4 ± 16.2 years and the male/female ratio was 3.4:1.0. The prevalence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; HIV infection; Prevalence; Brazil; Bahia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200007

Prevalence of human immunodeficiency virus/hepatitis C virus co-infection in Brazil and associated factors: a review
Provedor de dados: 55
Autores: Kuehlkamp,Valdete Meurer; Schuelter-Trevisol,Fabiana.
The hepatitis C virus and human immunodeficiency virus share the same transmission routes, which makes co-infection an unfavorable condition for the natural history of both viral diseases. In this context, it should be highlighted that the knowledge of the extent of co-infection and associated risk factors is a vital tool for prevention and control over infectious diseases. The aim of this study was to review the literature, seeking to examine the prevalence of human immunodeficiency virus/hepatitis C virus co-infection reported in studies conducted in Brazil, and identify the main risk factors associated with co-infection. The electronic search was conducted in the Medline, Lilacs and SciELO databases. The following keywords were used: human...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis C; Co-infection; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400012

Prevalence of human Papilloma Virus in HIV-positive and HIV-negative patients in the State of Bahia: a pilot study
Provedor de dados: 55
Autores: Queiroz,Conceição; Travassos,Ana Gabriela; Studart,Eduardo; Araújo Filho,José Bouzas; Sarno,Carla Kruchewsky; Pinheiro,Carla Cristiane.
Human Papilloma Virus (HPV) plays a central role in the development of cervical cancer. However, other coexisting factors, such as HIV infection, must be present for this to occur. We evaluated the prevalence of HPV in HIV-positive and HIV-negative patients in the city of Salvador , Bahia, Brazil, and determined the most prevalent types of HPV in these patients. Fifty-five cases were selected from among patients attending three institutions providing cervical pathology services in the city of Salvador. HIV testing (Elisa/WB), HPV-DNA testing by PCR, colposcopy, cytology and biopsy were carried out in all patients. The histopathological results were classified as follows: 11 cases were normal/negative for neoplasia, 15 were diagnosed as cervical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human papilloma virus (HPV); Human immunodeficiency virus (HIV); Cervical intraepithelial neoplasias (CIN); Cervical invasive carcinoma.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500004

Prevalence of human papillomavirus (HPV) and HPV-16 genotyping by real-time PCR in patients with several cervical pathologies
Provedor de dados: 55
Autores: Dinc,Bedia; Rota,Seyyal; Onan,Anil; Bozdayi,Gulendam; Taskiran,Cagatay; Biri,Aydan; Güner,Haldun.
PURPOSE: this study was planned to evaluate the prevalence of HPV (excepting type 16) and HPV 16 by real-time PCR in colposcopy patients and to interprete the results with age, age of first sexual intercourse (FSI), parity and Pap smear results. METHODS: one hundred and two colposcopy patients (50 and 52 of the patients were classified as colposcopy positive and negative, respectively) applying to Gynecology clinic were included. HPV (excepting type 16) and HPV 16 were detected by realtime PCR using the L1 region. Real-time nested amplifications of MY09/11 products were done by GP5+/GP6+ primers and Cyanine-5 labeled HPV and HPV 16 DNA specific probe after HPV DNA extraction by phenol chloroform isoamylalcohol. RESULTS: HPV (excepting type 16) and HPV 16...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV type 16; Real-time PCR; Colposcopy.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100005

Prevalence of human papillomavirus infection in the genital tract determined by hybrid capture assay
Provedor de dados: 55
Autores: Carestiato,Fernanda N.; Silva,Katia C; Dimetz,Trude; Oliveira,Ledy H. S.; Cavalcanti,Silvia M. B.
Human Papillomavirus (HPV) infection is the most prevalent sexually-transmitted virus worldwide. It is known to be the etiological agent of cervical cancer and cervical intraepithelial neoplasia (CIN). Consequently, there is strong motivation to evaluate HPV testing in cervical cancer screening. Recently developed, the second generation of the hybrid capture test (HCA II) is a non-radioactive, relatively rapid, hybridization assay, designed to detect 18 HPV types divided into high and low-risk groups. We evaluated 7,314 patients (5,833 women and 1,481 men) for HPV infection by HCA II. Among them, 3,008 (41.1%) presented HPV infection: 430 (14.2%) had HPV DNA of low risk for cancer, 1,631 (54.2%) had high risk HPV types and 947 (31.5%) had both types. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; SIL; Cancer; Hybrid capture.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500006

Prevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazil
Provedor de dados: 55
Autores: Rizzo,Silvia Renata Cornelio Parolin; Gazito,Diana; Pott-Junior,Henrique; Latini,Flavia Roche Moreira; Castelo,Adauto.
ABSTRACT The recent development of interferon-free regimens based on direct-acting antivirals for the treatment of chronic hepatitis C virus infection has benefited many but not all patients. Some patients still experience treatment failure, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism. The present study assessed the prevalence of rs12979860-CC, rs12979860-CT, and rs12979860-TT genotypes of the IFNL3 gene, and its relationship with ancestry informative markers in 949 adult Brazilian healthy blood donors. Race was analyzed using ancestry informative markers as a surrogate for ancestry. IFNL3 gene was genotyped using the ABI TaqMan single nucleotide polymorphisms genotyping assays. The overall frequency of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Ancestry informative markers; Chronic hepatitis C virus infection; Direct-acting antivirals; Single nucleotide polymorphisms.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600619

Prevalence of indeterminate human immunodeficiency virus western blot results in pregnant women attended at a public hospital in Presidente Prudente, Brazil
Provedor de dados: 55
Autores: Cremonezi,Denise; Mesquita,Paulo Eduardo de; Romão,Marisa Menezes; Prestes-Carneiro,Luiz Euribel.
The AIDS epidemic is spreading rapidly among women worldwide, offering increasing opportunities for vertical transmission of HIV. In Brazil, the prevalence of HIV infection among pregnant women is less than 1%. Therefore, the positive predictive value of an HIV EIA test tends to be lower than the more frequent indeterminate Western blot result. Pregnant women receiving antenatal care, from 2000 to 2004, at a public secondary hospital in the city of Presidente Prudente, São Paulo, Brazil, were systematically screened for HIV by means of two distinct EIA tests, in order to determine the prevalence of indeterminate Western blot results among pregnant women showing discordance in both HIV EIA tests and indirect immunofluorescence assay. Confirmatory indirect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Indeterminate Western blot; Pregnant women.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600009

Prevalence of lipodystrophy and risk factors for dyslipidemia in HIV-infected children in Brazil
Provedor de dados: 55
Autores: Papi,Luanda; Menezes,Ana Carolina G.B.; Rocha,Hélio; Abreu,Thalita F.; Oliveira,Ricardo Hugo de; Frota,Ana Cristina C.; Evangelista,Lucia de A.; Hofer,Cristina B.
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol &gt;200 mg/dl or triglycerides &gt;130 mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Dyslipidemia; Children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400394

Prevalence of maternal group B streptococcal colonization and related risk factors in a Brazilian population
Provedor de dados: 55
Autores: Zusman,Alexander S.; Baltimore,Robert S.; Fonseca,Silvia N.S.
The objective of this study was to determine the prevalence of maternal group B Streptococcal (GBS) colonization and compare risk factor data related to GBS colonization. A prospective surveillance study of 598 pregnant women was conducted in two socioeconomically diverse maternity hospitals in Ribeirão Preto, Brazil between June and October 1999. Swabs from the lower vagina were obtained between 35 and 37 weeks gestation and cultured on selective media. Risk factor data were obtained by patient interview and chart review. The overall maternal GBS colonization prevalence rate was 17.9%. There was no association of GBS colonization with maternity hospital and no association of GBS colonization with previously identified risk factors, such as age, race,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Group B Streptococcus (GBS); Colonization; Neonatal sepsis; Brazil; Latin America; Risk factors.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400005

Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among patients visiting the emergency room at a tertiary hospital in Brazil
Provedor de dados: 55
Autores: Ribeiro,Julival; Boyce,John M.; Zancanaro,Pedro Q.
We surveyed patients seen at the emergency room at a tertiary hospital in Brazil from August to November 1997. All patients' (n = 600) anterior nares were cultured for MRSA; the results were confirmed by oxacillin disk diffusion methods and by detection of the mecA gene with PCR. Bacteria were found in 93.3% (560) of the patients and MRSA in 0.7% (n = 4). One patient had community-acquired MRSA. We concluded that MRSA is uncommon among patients visiting the emergency room. The presence of community-acquired MRSA can lead to serious medical and epidemiological issues, although initial clinical presentation may not differ from that of infections with other staphylococci. The empirical use of vancomycin for suspected community-acquired infections is seldom...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Staphylococcus aureus; Emergency room; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100009

Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China
Provedor de dados: 55
Autores: Zhao,Youyun; Wu,Jianhua; Sun,Lijun; Liu,Guangzhong; Li,Bo; Zheng,Yi; Li,Xiaodong; Tao,Junxiu.
Abstract  Objective There are a lot of disagreements in the studies on hepatitis B virus (HBV) DNA polymerase mutation rate associated with nucleos(t)ide analogues (NAs) in treatment-naive chronic hepatitis B (CHB) patients. This is the first study aimed to investigate the prevalence of spontaneous HBV resistance mutations in Central China.  Methods This study included treatment-naive patients with CHB from June 2012 to May 2015 receiving care at the Institute of Liver Disease in Central China. All patients completed a questionnaire covering different aspects, such as family medical history, course of liver disease, medication history, alcohol use, among others. Mutations in HBV DNA polymerase associated with NAs resistance were detected using INNO-LiPA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Chronic hepatitis B; Viral resistance mutations.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200173

Prevalence of mycobacteremia in patients with AIDS and persistant fever
Provedor de dados: 55
Autores: Bacha,Hélio Arthur; Cimerman,Sérgio; Souza,Simone A. de; Hadad,David Jamil; Mendes,Caio Márcio Figueiredo.
In the advanced stages of AIDS, characterized by severe immunodepression, tuberculosis (TB) may present with a clinical picture of septic shock, due to typical bacteremia. Hematogenic dissemination of mycobacteria is frequent in immunodepressed patients with TB or disseminated mycobacteriosis, leading to increased positivity in detection by automated blood culture. The objective of our study was to determine the prevalence of mycobacteremia in patients with AIDS and with prolonged fever seen at the Emilio Ribas Institute of Infectology. Patients with a history of daily fever (37.8ºC), lasting more than 30 days, and with CD4+ helper lymphocyte counts below 200 cells/mL, were selected from February 2001 to March 2002. A 5 mL peripheral blood sample was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Automated blood culture; AIDS.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400004

Prevalence of Mycobacterium avium and Mycobacterium tuberculosis in blood cultures of Brazilian AIDS patients after introduction of highly active retroviral therapy
Provedor de dados: 55
Autores: Nakatani,S.M.; Messias-Reason,I.J.T.; Burger,M.; Cunha,C.A.
The use of highly active antiretroviral therapy (HAART) for the treatment of HIV infection has been associated with a marked reduction in the incidence of most opportunistic infections. From April 2001 to February 2002, 80 blood samples from patients who were suspected to have disseminated mycobacterial infection, presenting fever and (preferably) a CD4 T cell count &lt; 100.0 cell/mL were investigated. Twelve (15%) of the 80 blood cultures were positive for mycobacteria, with Mycobacterium avium being identified in 7 (8.8%) samples and M. tuberculosis in 5 (6.2%). The TCD4+ count at the time of M. avium bacteremia ranged from 7cells/µL (average of 48.5 cell/µL), while in M. tuberculosis bacteremia it ranged from 50.0 cells/µL (average of 80.0 cell/µL)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteremia; M. avium; M. tuberculosis; AIDS.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600003

Prevalence of newborn bacterial meningitis and sepsis during the pregnancy period for public health care system participants in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Silva,Luzia Poliana Anjos da; Cavalheiro,Laura Giotto; Queirós,Fernanda; Nova,Camila Vila; Lucena,Rita.
Bacterial meningitis is still a major public health threat inside developing countries. In Brazil, the Department of Public Health estimates that the prevalence of bacterial meningitis is 22 cases per 100,000 persons. During the neonatal period, the bacterial meningitis develops special characteristics that can result in hearing problems and movement loss due to neurological and psychological damages. This study had the aim to analyze the prevalence of bacterial meningitis and sepsis in newborns during the pregnancy period for those using the public health care system in Salvador-Bahia. One of the goal was to describe the risk factors of bacterial meningitis and sepsis in newborns. A second goal was to identify, based on newborn health records, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Newborn meningitis; Sepsis; Prevalence; Prediction; Complications.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200021

Prevalence of pathogens in cystic fibrosis patients in Bahia, Brazil
Provedor de dados: 55
Autores: Santana,Maria Angélica; Matos,Eliana; Fontoura,Maria do Socorro; Franco,Rosana; Barreto,Danyella; Lemos,Antônio Carlos M.
INTRODUCTION: Recurrent respiratory infections account for most of the morbidity and mortality of cystic fibrosis patients. MATERIALS AND METHODS: The objective was to determine the prevalence of pathogens isolated from lower respiratory tract secretions in cystic fibrosis patients. In this descriptive observational study, data from 69 patients was collected from medical records. RESULTS: The microorganisms that were identified included 36.2% P. aeruginosa, 28.9% S. Aureus, 4.3% K. pneumoniae, 1.5% H. influenzae, 1.5% E. coli, 1.5% S. maltoophilia, and in 27.5% the flora was normal. The prevalence of P. aeruginosa was 83% in patients under two years of age, demonstrating early colonization. CONCLUSION: P. aeruginosa and S. aureus were the most prevalent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cystic fibrosis; Pathogens; Bahia; Brazil.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100008

Prevalence of persistent proteinuria in stable HIV/AIDS patients and its association with HIV nephropathy
Provedor de dados: 55
Autores: Cavalcante,Maria Alina Gomes de Mattos; Coelho,Sandra Neiva; Lacerda,Heloísa Ramos.
Human immunodeficiency virus (HIV)-related glomerular disease is a cause of end-stage renal disease, though there is no recent data from Brazil concerning this syndrome. Persistent proteinuria (PPt) is the main marker for glomerular disease, especially levels above 1.5 g. We examined the prevalence of and associated risk factors for PPt, along with the prevalence of HIV-associated nephropathy (HIVAN) among AIDS patients. We interviewed 411 patients who were attended at the HIV/AIDS section of the Clinical Hospital of the Federal University of Pernambuco (Brazil) from January through June 2004. PPt was defined as a positive urine dipstick exam on at least two occasions. The analyzed risk factors were: black race, a low CD4 lymphocyte count (&lt;200...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Proteinuria; HIV nephropathy; AIDS.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500003

Prevalence of phenotypic resistance of Staphylococcus aureus isolates to macrolide, lincosamide, streptogramin B, ketolid and linezolid antibiotics in Turkey
Provedor de dados: 55
Autores: Adaleti,Riza; Nakipoglu,Yasar; Ceran,Nurgul; Tasdemir,Cihan; Kaya,Fatma; Tasdemir,Semiha.
The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage of antibiotics. The purpose of this study was to investigate the phenotypic resistance of 321 methicillin resistance Staphylococcus aureus (MRSA) and 195 methicillin susceptible S. aureus (MSSA) in a total of 516 S. aureus strains to macrolide, lincosamide, streptogramin B (MLS B), ketolid, and linezolid. Disk diffusion method was applied to determine MLS B phenotype and susceptibility to different antibiotic agents. It was found that 54.6% of the isolates were resistant to erythromycin (ERSA), 48% to clindamycin, 55% to azithromycin, 58.7% to spiramycin, 34.7% to telithromycin, and 0.4% to quinupristin-dalfopristin, respectively. No strain...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Macrolide; Lincosamide; Streptogramin B; Ketolid; Linezolid; MLS B.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100003

Prevalence of pneumococcal serotypes and resistance to antimicrobial agents in patients with meningitis: ten-year analysis
Provedor de dados: 55
Autores: Alvares,Jackelline Rodrigues; Mantese,Orlando Cesar; Paula,Alan de; Wolkers,Paula Carolina Bejo; Almeida,Viviene Vieira Prado; Almeida,Samanta Cristine Grassi; Guerra,Maria Luiza Leopoldo Silva; Brandileone,Maria Cristina de Cunto.
OBJECTIVES: To determine the prevalence of pneumococcal serotypes and antimicrobial susceptibility in patients with meningitis, and to evaluate the implications for vaccine coverage. METHODS: Pneumococcal strains obtained from normally sterile fluids from patients admitted with meningitis were isolated at the Hospital de Clínicas of the Universidade Federal de Uberlândia, Minas Gerais State, and sent to the Instituto Adolfo Lutz, city of São Paulo, São Paulo State, for further identification, serotyping, and antimicrobial susceptibility determination. RESULTS: From April 1999 to April 2009, 338 pneumococcal strains were isolated, and 72 obtained from patients with meningitis, were analyzed. Patients' ages varied from one month to 82.2 years (mean of 18.4 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Meningitis; Serotyping; Pneumococcal vaccines; Drug resistance.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100005

Prevalence of potentially pathogenic free-living amoebae from Acanthamoeba and Naegleria genera in non-hospital, public, internal environments from the city of Santos, Brazil
Provedor de dados: 55
Autores: Teixeira,Lais Helena; Rocha,Silvana; Pinto,Rosa Maria Ferreiro; Caseiro,Marcos Montani; Costa,Sergio Olavo Pinto da.
Acanthamoeba and Naegleria species are free-living amoebae (FLA) found in a large variety of natural habitats. The prevalence of such amoebae was determined from dust samples taken from public non-hospital internal environments with good standards of cleanliness from two campuses of the same University in the city of Santos (SP), Brazil, and where young and apparently healthy people circulate. The frequency of free-living amoebae in both campuseswas 39% and 17% respectively, with predominance of the genus Acanthamoeba. On the campus with a much larger number of circulating individuals, the observed frequency of free-living amoebae was 2.29 times larger (P&lt; 0.00005). Two trophozoite forms of Naegleria fowleri, are the only species of this genus known to...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Free - living amoebae; Acanthamoeba spp.; Naegleria spp.; Prevalence; Dust from internal environments; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600001

Prevalence of resistance-associated mutations in Human Immunodeficiency Virus type 1-positive individuals failing HAART in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Varella,Rafael Brandão; Ferreira,Selma Baía; Castro,Márcia Braga de; Tavares,Marisa Dias; Zalis,Mariano Gustavo.
We investigated the occurrence of HIV-1 antiretroviral resistance in individuals failing to respond to highly active antiretroviral therapy (HAART) attended by RENAGENO from 2001-2004. One hundred and seventeen patients were selected for this study; their plasma viral RNA was extracted and the PR and RT genes sequenced to examine subtype, genetic polymorphisms and mutations associated with resistance to antiretroviral drugs. HIV-1 sequence analysis showed that 86/100 (86%) were infected with subtype B, 7/100 (7%) with subtype F and 7/100 (7%) with RT/PR hybrid forms (2 D/B, 2 F/B, 2 B/F and 1 D/F). In 14 (12%) of the samples, the subtype was not determined. The prevalence of resistance mutations was high (93.1%), mainly in the RT gene. The most prevalent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; HAART; Reverse transcriptase; Protease; Resistance.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500007

Prevalence of rhinovirus in wheezing children: a comparison with respiratory syncytial virus wheezing
Provedor de dados: 55
Autores: Sun,Huiquan; Sun,Qiufeng; Jiang,Wunjun; Chen,Zhengrong; Huang,Li; Wang,Meijuan; Ji,Wei; Shao,Xuejun; Yan,Yongdong.
Abstract  Objective To explore the distribution and clinical manifestations of rhinovirus infection in wheezing children, and compare the clinical differences between rhinovirus- and respiratory syncytial virus-induced wheezing.  Materials and methods This prospective cohort study was carried out in Children's Hospital of Soochow University from Dec 2012 to Nov 2014. We enrolled consecutive hospitalized children &lt;60 months of age presented with wheezing. Clinical data including cough, fever, dyspnea, crackles were recorded by pediatricians on the first day of admission. Meanwhile, nasopharyngeal aspirates were obtained to test for respiratory viruses, by using polymerase chain reaction method for rhinovirus, human bocavirus, and human metapneumovirus,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rhinovirus; Respiratory syncytial virus; Wheezing.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200179

Prevalence of selected sexually and blood-borne infections in Injecting drug abuser inmates of bandar abbas and roodan correction facilities, Iran, 2002
Provedor de dados: 55
Autores: Davoodian,Parivash; Dadvand,Habib; Mahoori,Khatereh; Amoozandeh,Alireza; Salavati,Alborz.
Human Immunodeficiency Virus (HIV) and other blood borne viral infections like hepatitis B virus (HBV) and hepatitis C virus (HCV) are major health issues especially in young and growing population of developing countries. All around the globe correctional facilities are known as potential source of spreading such disease. During summer 2002, HIV, HCV antibodies, hepatitis B surface (HBs) antigen and rapid plasma reagin (RPR) test were checked in venous blood samples of 252 injecting drug abuser prisoners from correctional facilities in southern Iran. Overall HIV, HCV and HBV infection rate was 15.1% (38/249), 64.8% (163/249), and 4.7% (12/249), respectively. HCV infection rate of HIV positive cases was 94% (35/38). All RPR results were negative. Duration...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Iran; Prisons; HBV; HCV.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500008

Prevalence of sexually transmitted infections among HIV-infected women in Brazil
Provedor de dados: 55
Autores: Travassos,Ana Gabriela Álvares; Brites,Carlos; Netto,Eduardo M.; Fernandes,Sheyla de Almeida; Rutherford,George W.; Queiroz,Conceição Maria.
This study aimed to evaluate the prevalence of sexually transmitted infections (STIs) and associated risk factors in HIV-infected pregnant women followed for prenatal care in Salvador, Bahia. This was a cross-sectional study of 63 women seeking prenatal care at a reference center. Participants were interviewed regarding socio-epidemiological and clinical history, and were tested for HBsAg, anti-HCV, anti HTLV I/II, VDRL, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis, Ureaplasma urealyticum, CD4 count, and HIV plasma viral load. The main outcome variable was the presence of any STI. The mean age of patients was 28.2 years (16-40 years). 23 (36.5%) were diagnosed with at least one STI. The frequency of diagnoses was: HBV, 3.2%; HCV, 8.1%;...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Sexually transmitted infections; Pregnancy; Prevalence.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600014

Prevalence of Staphylococcus aureus introduced into intensive care units of a University Hospital
Provedor de dados: 55
Autores: Cavalcanti,Silvana M.M.; França,Emmanuel R. de; Cabral,Carlos; Vilela,Marinalda A.; Montenegro,Francisco; Menezes,Daniela; Medeiros,Ângela C.R.
Staphylococcus aureus is one of the principal human pathogens that colonize healthy individuals in the community in general, and it is responsible for severe infections in hospitalized patients. Due to an increase in the prevalence of strains of methicillin-resistant S. aureus (MRSA), combating these microorganisms has become increasingly difficult. A descriptive study was carried out on 231 patients in intensive care at the Oswaldo Cruz University Hospital (HUOC) in Recife, Brazil between January and April 2003 to determine the prevalence of S. aureus and MRSA and to evaluate risk factors for colonization by these bacteria when introduced into Intensive Care Units (ICUs). Body secretions were collected from the nostrils, axillary and perineal regions, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Methicillin-resistant; Intensive care unit.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100010

Prevalence of toxoplasmosis, HIV, syphilis and rubella in a population of puerperal women using Whatman 903® filter paper
Provedor de dados: 55
Autores: Madi,José Mauro; Souza,Ricardo da Silva de; Araújo,Breno Fauth de; Oliveira Filho,Petrônio Fagundes de; Rombaldi,Renato Luís; Mitchell,Charles; Lorencetti,Jucemara; Marcon,Nathalia Oliva.
OBJECTIVES: to determine the seroprevalence rate of toxoplasmosis, HIV, syphilis and rubella in a population of puerperal women. METHODS: a prospective, cross-sectional study was performed from February 2007 to April 2008 at Hospital Geral, Universidade de Caxias do Sul in a population of 1,510 puerperal women. Women that gave birth to live born or stillborn infants were included in the study; maternal and perinatal variables were analyzed. Descriptive statistics and Pearson's chi-square with occasional Fisher's correction were used for comparisons. Alpha was set in 5%. RESULTS: a total of 148 cases of congenital infection (9.8%) were identified: 66 cases of syphilis (4.4%), 40 cases of HIV (2.7%), 27 cases of toxoplasmosis (1.8%) and 15 cases of rubella...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Perinatal infections; Congenital infections; Clinical diagnosis; Seroprevalence.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100006

Prevalence of Trypanosoma cruzi/HIV coinfection in southern Brazil
Provedor de dados: 55
Autores: Stauffert,Dulce; Silveira,Mariangela Freitas da; Mesenburg,Marília Arndt; Manta,Adriane Brod; Dutra,Alessandra da Silva; Bicca,Guilherme Lucas de Oliveira; Villela,Marcos Marreiro.
Abstract Chagas disease reactivation has been a defining condition for acquired immune deficiency syndrome in Brazil for individuals coinfected with Trypanosoma cruzi and HIV since 2004. Although the first coinfection case was reported in the 1980s, its prevalence has not been firmly established. In order to know coinfection prevalence, a cross-sectional study of 200 HIV patients was performed between January and July 2013 in the city of Pelotas, in southern Rio Grande do Sul, an endemic area for Chagas disease. Ten subjects were found positive for T. cruzi infection by chemiluminescence microparticle immunoassay and indirect immunofluorescence. The survey showed 5% coinfection prevalence among HIV patients (95% CI: 2.0–8.0), which was 3.8 times as high as...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chagas disease; Trypanosoma cruzi; AIDS.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200180

Prevalence, risk factors and genotypes of hepatitis B infection among HIV-infected patients in the State of MS, Central Brazil
Provedor de dados: 55
Autores: Freitas,Solange Zacalusni; Soares,Caroline Cordeiro; Tanaka,Tayana Serpa Ortiz; Lindenberg,Andréa Siqueira Campos; Teles,Sheila Araújo; Torres,Marina Sawada; Mello,Francisco Campello Amaral; Mendes-Corrêa,Maria Cássia; Savassi-Ribas,Flávia; Motta-Castro,Ana Rita Coimbra.
Objectives:A cross-sectional study on prevalence of HBV and HDV infection, risk factors and genotype distribution of HBV infection was conducted among 848 HIV-infected patients in Mato Grosso do Sul, Central Brazil.Methods:Serum samples of 848 participants were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc) and hepatitis surface antibody (anti-HBs). HBsAg positive samples were tested for anti-HBc IgM, HBeAg, anti-HBe, anti-HCV, and total anti-HDV. HBsAg and anti-HBc positive were subjected to DNA extraction. Viral DNA was amplified by semi-nested PCR for the regions pre-S/S and then purified and genotyped/subgenotyped by direct sequencing. Student's t-test, chi-square test and Fisher's exact test were used to compare...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coinfection; HBV; HIV; Prevalence.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500473

Prevalence, susceptibility profile for fluconazole and risk factors for candidemia in a tertiary care hospital in southern Brazil
Provedor de dados: 55
Autores: Aquino,Valério Rodrigues; Lunardi,Luciano W.; Goldani,Luciano Zubaran; Barth,Afonso Luis.
Bloodstream infections caused by yeast, Candida spp, are quite important clinically and epidemiologically due to a high mortality rate and an increasing number of non-albicans species with a more resistant (differentiated susceptibility) profile. We examined species prevalence and susceptibility profile for fluconazole and the risk for nosocomial infections by Candida spp at the Hospital de Clínicas de Porto Alegre, a general tertiary care hospital in southern Brazilian, through a retrospective study, beginning with positive cultures of hospitalized patients. The distribution by species in 131 documented episodes was as follows: Candida albicans (45%), C. parapsilosis (24.4%), C. tropicalis (15.3%), C. glabrata (6.9%), C. krusei (4.6%) and 3.8% other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fluconazole; Candidemia; Risks; Southern Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500009

Preventing catheter-associated infections in the Pediatric Intensive Care Unit: impact of an educational program surveying policies for insertion and care of central venous catheters in a Brazilian teaching hospital
Provedor de dados: 55
Autores: Abramczyk,Marcelo Luiz; Carvalho,Werter B; Medeiros,Eduardo A.S.
Objectives: To determine the impact of an educational program on the prevention of central venous catheter-related infections in a Brazilian Pediatric Intensive Care Unit. Patients and Methods: All patients admitted to the unit between February 2004 and May 2005 were included in the cohort study in a longitudinal assessment. An educational program was developed based on the Centers for Disease Control and Prevention recommendations for prevention of catheter-associated infections and was adapted to local conditions and resources after an initial observational phase. Incidence of catheter-associated infections was measured by means of on-site surveillance. Results: One hundred eighteen nosocomial infections occurred in 253 patients (46.6 infections per 100...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Catheterization; Central venous intensive care units pediatric disease prevention.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600012

Prevention strategies for methicillin-resistant Staphylococcus aureus (MRSA) in Latin America
Provedor de dados: 55
Autores: Alvarez,Carlos; Labarca,Jaime; Salles,Mauro.
After the first reports of the emergence of methicillin-resistant Staphylococcus aureus (MRSA) in the 1970s, numerous measures intended to prevent its transmission were initiated in hospitals. However, in most cases, large-scale measures failed to be implemented and the transmission of MRSA has since led to a global pandemic. Presently, doubts still remain about the best approach to prevent and control MRSA and more often than not, control measures are not implemented. Therefore, we review here the current situation in Latin America with respect to existing policies for control of MRSA, and evaluate the evidence for control measures in hospitals and the community. We look at the risk factors for infection and transmission of MRSA between hospital patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Prevention; Infection control; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800006

Preventive health care for an endangered species - the physician scientist
Provedor de dados: 55
Autores: Badaró,Roberto; Jones,Thomas C.
Tipo: Info:eu-repo/semantics/other
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200009

Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis C
Provedor de dados: 55
Autores: Bricks,Guilherme; Senise,Jorge Figueiredo; Pott-Jr,Henrique; Grandi,Giuliano; Carnaúba-Jr,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.
ABSTRACT  Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance.  Methods: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).  Results: The seroprevalence of anti-HEV in patients with cirrhosis was significantly higher than in patients without...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Liver cirrhosis; Insulin resistance.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100045

Previous use of quinolones: a surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?
Provedor de dados: 55
Autores: Deutschendorf,Caroline; Goldani,Luciano Z.; Santos,Rodrigo Pires dos.
OBJECTIVES: Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV-infected patients in southern Brazil and studied the potential factors associated with resistance. METHODS: We conducted a retrospective cohort study to determine the resistance profile of Mycobacterium tuberculosis isolated from HIV-infected patients and factors that could be associated with resistance from 2000 to 2005. RESULTS: 236 patients were included in the study. Resistance to at least one drug was observed in 32 (14.6%) isolates, and multi-drug resistance was observed in 4 (1.82%) isolates. On...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; HIV; Quinolones; Drug resistance.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200006

Primary amoebic meningoencephalitis: first reported case from Rohtak, North India
Provedor de dados: 55
Autores: Gupta,Naveen; Bhaskar,Hemlata; Duggal,Shalini; Ghalaut,Pratap S.; Kundra,Shailja; Arora,Des R.
A fatal case of primary amoebic encephalitis (PAM) in a 20 year old boy, a proven case of acute leukemic leukemia (ALL) type L2, in remission is described. No history of swimming could be elicited. The clinical presentation, the isolation of the amoeba from the cerebrospinal fluid (CSF), the poor response to amphotericin B, and the ultimately fatal outcome are all consistent with the diagnosis of PAM. On the basis of its ability to grow at temperature 42ºC and 45ºC, morphology of trophozoite, and the presence of flagellate forms in CSF, the amoeba was identified as Naegleria fowleri. Other drugs used in combination with amphotericin B are tetracycline, rifampicin, and miconazole. A possibility of PAM should always be considered in all cases of acute...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Naegleria; Meningoencephalitis; Fatal.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300016

Primary anterior parietal wall abscess due to Salmonella Typhi
Provedor de dados: 55
Autores: Thakur,Kamlesh; Singh,Gagandeep; Gupta,Poonam; Chauhan,Smriti; Jaryal,Subhash Chand.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400002

Primary care physicians and infectious diseases' notification
Provedor de dados: 55
Autores: Duric,Predrag; Ilić,Svetlana.
Tipo: Info:eu-repo/semantics/article
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200021

Primary gastric fundus tuberculosis in immunocompetent patient: a case report and literature review
Provedor de dados: 55
Autores: Khan,Fahmi Yousef; AlAni,Ahmed; Al-Rikabi,Ammar; Mizrakhshi,A.; Osman,Mohamed El-Mudathir.
We report on a 29-year-old Pakistani man who presented to the clinic with epigastric pain, of one-month duration. He did not report fever, cough, vomiting blood, passing black stools, loss of appetite or diarrhea. However, he had lost 7 kg since his symptoms had begun. Clinical examination was unremarkable. Laboratory results were within normal limits. An abdominal CT scan showed a mass with enhancement in the stomach. Gastric endoscopy revealed an ulcerative mass in the fundus. An endoscopic-biopsy specimen revealed caseating granulomas with acid-fast bacilli. The patient was diagnosed to have primary gastric tuberculosis, and antituberculous medications were initiated. Cultures of the gastric mass subsequently grew Mycobacterium tuberculosis sensitive to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gastric tuberculosis; Hematemesis; Peptic ulcer; Stomach perforation.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500020

Primary hydatid disease in the adrenal gland: a case report
Provedor de dados: 55
Autores: Özarmagan,Selçuk; Erbil,Yesim; Barbaros,Umut; Salmaslioglu,Artur; Bozbora,Alp.
Hydatid cysts may be found in almost any part of the body, but most often they are found in the liver and lungs. Other organs that are occasionally affected include the brain, muscle, kidney, heart, pancreas, and adrenal and thyroid glands. We report a case of hydatid cyst of the adrenal gland.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hydatid cyst; Hydatid disease; Adrenal.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500012

Primary isolated gingival tuberculosis
Provedor de dados: 55
Autores: Rodrigues,Gabriel; Carnelio,Sunitha; Valliathan,Maanna.
Tuberculosis of the oral cavity is a rare event and when present is usually secondary to pulmonary tuberculosis. We present a case of a 33-year-old male patient who presented with symptoms of gingivitis. Local examination revealed multiple ulcers and a few nodules over the gingiva. A nodule biopsy was consistent with the diagnosis of gingival tuberculosis. The patient had no evidence of tuberculosis any where else in the body. Medical treatment was curative. As this condition is very rare, it is often over looked as it is never thought as a common clinical diagnosis. A biopsy is mandatory to establish diagnosis. The relevant literature is reviewed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Gingiva; Tuberculosis; Mycobacteria; Antituberculous treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100037

Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host
Provedor de dados: 55
Autores: Dias,Levindo Tadeu Ferreira Figueiredo; Rodrigues,Gisane Cavalcanti; Barbosa,Diogo Santos; Lacerda,Domício Carvalho; Ruas,Marcelo Freire.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200016

Primary onychomycosis with granulomatous Tinea faciei
Provedor de dados: 55
Autores: Tchernev,Georgi; Cardoso,José Carlos; Ali,Musheera Mohammad; Patterson,James W.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500022

Primary pneumococcal peritonitis in an immunocompetent child
Provedor de dados: 55
Autores: Maraki,Sofia; Spathopoulou,Thomai; Ntaoukakis,Markos; Vlachakis,John.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100022

Primary pyomyositis and disseminated septic pulmonary emboli: a reactivated staphylococcal infection?
Provedor de dados: 55
Autores: Savvidou,Savvoula; Kalogiannis,Emmanouil; Tsakiri,Kalliopi; Gavra,Maria; Tsona,Afroditi.
Staphylococcal pyomyositis is a severe invasive soft tissue infection with high mortality rate that is increasingly being recognized even in temperate climates. In most cases predisposing factors are identified that include either source of skin penetration or/and impaired host immunocompetence. A case of primary, community-acquired pyomyositis of the left iliopsoas muscle in a 59-year-old immunecompetent woman, which was complicated with septic pulmonary emboli within 24 h after hospital admission, is presented. The patient was subjected to abscess drainage under computed tomography guidance. Both pus aspiration and blood cultures revealed methicillin-susceptible Staphylococcus aureus. Given the absolute absence of predisposing factors and a remote...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pyomyositis; Staphylococcus aureus; Septic pulmonary emboli; Reactivation.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400457

Primary sternal osteomyelitis caused by Nocardia nova: case report and literature review
Provedor de dados: 55
Autores: Baraboutis,Ioannis G.; Argyropoulou,Athena; Papastamopoulos,Vasilios; Psaroudaki,Zoi; Paniara,Olga; Skoutelis,Athanasios T.
A 51 year old woman without significant past medical history or risk factors for Nocardia infection developed primary Nocardia nova sternal osteomyelitis with mediastinal abscess, diagnosed with open biopsy. She required prolonged antibiotic therapy and had a favorable outcome. Primary sternal osteomyelitis develops in the absence of a contiguous focus of infection, as opposed to secondary sternal osteomyelitis, which is usually a complication of sternotomy. Staphylococcus aureus probably still is the most common cause of both forms of sternal osteomyelitis. Nocardia species invade humans usually through the respiratory tract and can cause a variety of localized infections through the hematogenous route. Pulmonary involvement may or may not coexist....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nocardia nova; Primary sternal osteomyelitis; Secondary sternal osteomyelitis; Nocardia osteomyelitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300018

Prior history of sexually transmitted diseases in women living with AIDS in São Paulo, Brazil
Provedor de dados: 55
Autores: Pinto,Valdir Monteiro; Tancredi,Mariza Vono; Golub,Jonathan Eric; Coelho,Ariane de Castro; Tancredi Neto,Antonio; Miranda,Angelica Espinosa.
OBJECTIVES: To describe the epidemiological profile, risk behaviors, and the prior history of sexually transmitted diseases (STDs) in women living with acquired immunodeficiency syndrome (AIDS). METHODS: Cross-sectional study, performed at the Centro de Referência e Treinamento em DST/AIDS of São Paulo. The social, demographic, behavioral, and clinical data such as age, schooling, marital status, age at first sexual intercourse, number of sexual partners, parity, use of drugs, time of HIV diagnosis, CD4 count, and viral load determination were abstracted from the medical records of women living with AIDS who had gynecological consultation scheduled in the period from June 2008 to May 2009. RESULTS: Out of 710 women who were scheduled to a gynecological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually transmitted diseases; Women; HIV; Behavior.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300002

Proceedings of the 1st International Symposium of Oncovirology
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600014

Proceedings of the II International Symposium on Oncovirology (november, 18-20, 2004) at Sol Victória Marina Hotel, Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Brites,Carlos.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500012

Production of monoclonal antibody to subtype 9 of Neisseria meningitidis and the distribution of this subtype in Brazil
Provedor de dados: 55
Autores: Belo,Elza F.T.; Coutinho,Ligia M.C.C.; Ferraz,Aline S.; De Gaspari,Elizabeth N.
A new monoclonal antibody (5F81A4P1.9), which is specific for subtype 9 antigen of meningococci, was studied. The antibodies were raised against a previously non-typable (NT) serogroup B strain from Brazilian patients and were found to react with the subtype antigen of prototype reference strains for subtype 9 (M982), as well as with those of homologous strains. The subtype 9 epitope was found in 6.8% of serogroup B strains among 602 strains of Neisseria meningitidis case isolates, including representative isolates from Brazilian states. Subtype P1.9 was predominantly related to serogroup B in Brazil among the isolates collected during the N. meningitidis epidemic in 1992. No significant differences were observed in the occurrence of subtype P1.9 among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neisseria meningitidis; Monoclonal antibodies; Brazilian meningococcus strains; Serotyping; Subtyping.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600004

Profile of antimicrobial resistance of bacteria isolated from cockroaches (Periplaneta americana) in a Brazilian health care institution
Provedor de dados: 55
Autores: Prado,Marinésia Aparecida; Gir,Elucir; Pereira,Milca Severino; Reis,Cleomenes; Pimenta,Fabiana Cristina.
Cockroaches carry microorganisms to sterilized materials, equipment and non-contaminated food in hospitals and in homes. Hence, they are regarded as major microbial vectors. We isolated and identified microorganisms from living cockroaches captured from a Brazilian health care institution and we determined the antimicrobial susceptibility profile of the isolates. Following collection, cockroaches were immobilized at 4ºC for 10 to 20 minutes, immersed in 0.8% saline solution and then homogenized. Next, the suspension was seeded in culture media: brain and heart agar infusion, MacConkey agar, Naito agar, and they were incubated for up to 48 hours at 37ºC. Sabouraud agar cultures were incubated at ambient temperature. The microbial colonies were analyzed with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cockroach; Microorganism; Nosocomial infection; Antimicrobial resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100006

Profile of Anti-Tp47 antibodies in patients with positive serology for syphilis analized by western blot
Provedor de dados: 55
Autores: Miranda,Ana Paula Félix de; Sato,Neuza Satomi.
In Brazil, syphilis is still a great problem of public health. Serological test is essential for syphilis diagnosis and the current trend is the use of recombinant antigen in the treponemal tests, due to its confirmed higher sensibility and specificity. The purpose of the present study was to analyze the profile of anti-Tp47 antibodies in patients with positive serology for syphilis. One hundred positive sera samples were analyzed by Western Blot (WB) technique, using the recombinant antigen (rTp47). Ten of them did not present antibodies against the fraction rTp47, the results were confirmed by WB using native T. pallidum antigen. All ten samples had antibodies against the fractions Tp17 and Tp15 and presented low reactivity in VDRL, negative results or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Syphilis; Treponema pallidum; Recombinant antigens; Serological test.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200008

Profile of patients diagnosed with AIDS at age 60 and above in Brazil, from 1980 until June 2009, compared to those diagnosed at age 18 to 59
Provedor de dados: 55
Autores: Fonseca,Marise Oliveira; Tupinambás,Unaí; Sousa,Artur Iuri Alves de; Baisley,Kathy; Greco,Dirceu Bartolomeu; Rodrigues,Laura.
OBJECTIVES: The aim of this study was to learn more about people diagnosed with acquired immunodeficiency syndrome (AIDS) at age 60 and above in Brazil, and to compare them with people diagnosed at a younger age. METHODS: This study was based on the analysis of secondary data from the Brazilian AIDS Program. The study population consisted of people diagnosed with AIDS at age 60 and above. The comparison group was comprised of a 20% random sample of people diagnosed at age 18 to 59, frequency-matched by year of diagnosis. RESULTS: 544,846 cases of AIDS were reported in Brazil from 1980 until June 2009. Over 90% of cases were diagnosed between 18 and 59 years of age, and 13,657 (2.5%) at age 60 and above. The first case of AIDS among the elderly was reported...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Elderly; Epidemiology; Brazil.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600009

Profile of users of drugs for the treatment of chronic hepatitis B available through the Brazilian Public Health System
Provedor de dados: 55
Autores: Wiens,Astrid; Lenzi,Luana; Grochocki,Mônica Cavichiolo; Correr,Cassyano Januário; Pontarolo,Roberto.
Treatment for chronic hepatitis B in Brazil are funded by the Ministry of Health and by the state Departments of Health. Clinical protocol and therapeutic guidelines approve the use of adefovir, entecavir, interferon-a, lamivudine, and tenofovir for the treatment of chronic hepatitis B. The aim of this study was to establish the profile of users of these drugs in the state of Paraná. A cross-sectional study was conducted with patients under treatment in Paraná in August 2011. The following data were obtained: gender, hepatitis B used drug, International Classification of Diseases, and regional health unit. The monthly cost of these drugs for the public health system was also calculated. 1,093 patients registered were found, 70% male, and 2.6% co-infected...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Chronic hepatitis B; Users profile; Treatments; Demographic profile.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400012

Profiling viral gene expression in lymphomas
Provedor de dados: 55
Autores: Dittmer,Dirk P.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500027

Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis
Provedor de dados: 55
Autores: Rodrigues,Denise Silva; Salomão,Reinaldo; Kallas,Esper Georges.
Three HIV-1-seronegative patients with disseminated tuberculosis presented significant depletion of T-cell counts, in CD4+ and/or CD8+ cells, associated with increased expression of activation marker CD38 on CD8+ T-lymphocytes. This finding raises the question of potential mechanisms involved in the activation or loss of T-cells in disseminated tuberculosis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Mycobacterium tuberculosis; Disseminated tuberculosis; Lymphocyte; Cellular activation.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100012

Prognostic indicators in bacterial meningitis: a case-control study
Provedor de dados: 55
Autores: Mendizabal,Maria de Fátima Magalhães Acioly; Bezerra,Phelipe Cunha; Guedes,Diego Lins; Cabral,Diogo Buarque Cordeiro; Miranda-Filho,Demócrito de Barros.
This was a case-control study to identify prognostic indicators of bacterial meningitis in a reference hospital in Pernambuco/Brazil. The data were collected from charts of 294 patients with bacterial meningitis between January 2000 and December 2004. Variables were grouped in biological, clinical, laboratory and etiologic agent/treatment. Variables selected in each step were grouped and adjusted for age. Two models were created: one containing clinical variables (clinical model) and other containing laboratory variables (laboratory model). In the clinical model the variables associated with death due to bacterial meningitis were dyspnea (p = 0.006), evidence of shock (p = 0.051), evidence of altered mental state (p = 0.000), absence of headache (p =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacterial meningitis; Prognostic indicators; Case-control study.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500005

Prognostic markers of symptomatic congenital cytomegalovirus infection
Provedor de dados: 55
Autores: Romanelli,Roberta Maia de Castro; Magny,Jean François; Jacquemard,François.
The objective of this research was to identify maternal and fetal characteristics as prognostic markers of congenital cytomegalovirus (CMV) infection. This is a descriptive study of 13 cases of congenital CMV infection referred to Institute de Puericulture et Perinatologie de Paris (IPP) from January 2005 to October 2006. Amniotic fluid puncture was performed to research CMV polimerase chain reaction (PCR). Cordocentesis and cord blood samples at delivery were also analyzed to determinate fetal platelets count, GGT, ASAT, ALAT, CMV-DNA and IgM antibody. Variables of symptomatic and asymptomatic infants were then compared. Data were analyzed by SPSS - 15.0. Mean gestational age of amniocentesis was 24.6 weeks and there was no difference of mean viral load...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Disease transmission; Vertical; Prenatal diagnosis; Prognosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100009

Progress towards meningitis prevention in the conjugate vaccines era
Provedor de dados: 55
Autores: Laval,Cristina Aparecida Borges; Pimenta,Fabiana Cristina; Andrade,João Guimarães de; Andrade,Soraya S.; Andrade,Ana Lucia S. S. de.
Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Conjugate vaccines; Hib conjugate vaccine; Pneumococcal conjugate vaccine; Meningococcal conjugate vaccine; Impact of Hib conjugate vaccine.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006

Progressive disseminated histoplasmosis: a systematic review on the performance of non-culture-based diagnostic tests
Provedor de dados: 55
Autores: Falci,Diego R.; Hoffmann,Elias R.; Paskulin,Diego D.; Pasqualotto,Alessandro C.
Abstract The diagnosis of progressive disseminated histoplasmosis is often a challenge to clinicians, especially due to the low sensitivity and long turnaround time of the classic diagnostic methods. In recent years, studies involving a variety of non-culture-based diagnostic tests have been published in the literature. We performed a systematic review by selecting studies evaluating non-culture-based diagnostic methods for progressive disseminated histoplasmosis. We searched for articles evaluating detection of antibody, antigens, as well as DNA-based diagnostic methods. A comprehensive PUBMED, Web of Science, and Cochrane Library search was performed between the years 1956 and 2016. Case reports, review articles, non-human models and series involving...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Disseminated histoplasmosis; Non-culture; Enzyme immunoassay; Diagnostic tests.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100007

Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus
Provedor de dados: 55
Autores: Gonçalves,Fabrício Guimarães; Lamb,Leslie; Del Carpio-O'Donovan,Raquel.
Progressive multifocal leukoencephalopathy is a neurological infectious disease caused by the John Cunningham polyomavirus (JCV), an opportunistic agent with worldwide distribution. This disease is frequently seen in immunosuppresed patients and rarely associated with systemic lupus erythematosus. In the central nervous system PML demyelinating lesions occur in the supratentorial compartment. The authors describe a rare case of PML secondary to SLE treatment with atypical presentation restricted to the posterior fossa.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: PML; Leukoencephalopathy; Progressive multifocal posterior fossa; Magnetic resonance; Spectroscopy; Diffusion weighted images.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600020

Prolonged irritative voiding symptoms due to Enterobius vermicularis bladder infestation in an adult patient
Provedor de dados: 55
Autores: Sammour,Zein Mohamed; Gomes,Cristiano Mendes; Tome,Andre Luiz Farinhas; Bruschini,Homero; Srougi,Miguel.
Enterobius vermicularis (pinworm) is one of the most prevalent intestinal parasites in the world. The urinary tract is rarely affected and few cases have been reported. We report a case of bladder infestation by mature female worms of E. vermicularis in a woman presenting with irritative voiding symptoms.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterobiasis; Urinary tract infection; Bladder.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400020

Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma
Provedor de dados: 55
Autores: Bittencourt,Achiléa L.; Andrade,Agnes Carvalho; Requião,Cristiane; Arruda,Maria da Gloria Bomfim; Araújo,Iguaracyra.
Abstract Hodgkin-like ATLL is a rare variant of adult T-cell leukemia/lymphoma (ATLL), a disease caused by human T-cell lymphotropic virus type-1 (HTLV-1). At admission, a 46-year-old female presented with lymphadenomegaly, lymphocytosis, slight elevation of LDH blood level, and acid-alcohol resistant bacilli in sputum and was being treated for pulmonary tuberculosis (Tb). She had lymphocytosis in the previous 20 months. Serology for HTLV-1 was positive. Lymph node was infiltrated by medium-sized lymphocytes with scattered Hodgkin and Reed-Sternberg-like cells CD30+, CS1-4+, and CD79a+. Background cells were CD4+ and CD25+. A clinical diagnosis of favorable chronic ATLL was given. She was treated with chemotherapy but later progressed to acute ATLL and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adult T-cell leukemia/lymphoma; HTLV-1 infection; Pulmonary tuberculosis; Hodgkin-like ATLL.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100119

Promotion of hand hygiene strengthening initiative in a Nigerian teaching hospital: implication for improved patient safety in low-income health facilities
Provedor de dados: 55
Autores: Uneke,Chigozie Jesse; Ndukwe,Chinwendu Daniel; Oyibo,Patrick Gold; Nwakpu,Kingsley Onuoha; Nnabu,Richard Chukwuka; Prasopa-Plaizier,Nittita.
Background:Health care-associated infection remains a significant hazard for hospitalized patients. Hand hygiene is a fundamental action for ensuring patient safety.Objective:To promote adoption of World Health Organization Hand Hygiene Guidelines to enhance compliance among doctors and nurses and improve patient safety.Methods:The study design was a cross sectional intervention in a Federal Teaching Hospital South-eastern Nigeria. Interventions involved training/education; introduction of hand rub; and hand hygiene reminders. The impact of interventions and hand hygiene compliance were evaluated using World Health Organization direct observation technique.Results:The post-intervention hand hygiene compliance rate was 65.3%. Hand hygiene indications showed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hand hygiene; Health worker; Patient safety; Compliance.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100021

Propionibacterium acnes-killed attenuates the inflammatory response and protects mice from sepsis by modulating inflammatory factors
Provedor de dados: 55
Autores: Silva,José Bruno Nunes Ferreira da; Oliveira,Samara Kelly Mendonça de; Campos,Ingrid Araújo; Carvalho-Júnior,Carlson Helder Reis de; Coutinho,Thiago da Cunha; Silva,Teresinha Gonçalves.
BACKGROUND: Sepsis is a systemic inflammation associated with infection caused by pathogenic micro-organisms with high mortality rates. OBJECTIVE: In this study, we investigated the protective effect of Propionibacterium acnes-killed against polymicrobial sepsis induced by cecal ligation and puncture. METHODS: The mice were treated by intramuscular route in 1, 3, 5, and 7 days before the cecal ligation and puncture induction. The control group animals received vehicle (saline solution 0.9%) and the animals of the treated group received the P. acnes-killed (0.4 mg/animal). After anesthesia, midline laparotomy was performed with exposure of cecum followed by ligature and one transverse perforation of the same, with a 18 G needle, for induction of lethal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Propionibacterium acnes; Immunomodulation; Sepsis; Cytokines.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100004

Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock
Provedor de dados: 55
Autores: Korish,Aida Abdelhamid; Arafa,Maha Mohamed.
BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflammatory response (SIR). METHODS: Fifty male Wister rats were divided into: control, LPS, and CAPE+LPS groups. Plasma concentrations of various cytokines, including TNF-α, IL-1α, IL-1β, IL-6, IL-4, IL-10, and sICAM-1 were evaluated. In addition, the histopathological changes in the hepatic and neural cells were assessed. RESULTS: The LPS group showed high inflammatory cytokines and sICAM-1 levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipopolysaccharides; Septic shock; Systemic inflammatory response syndrome; Cytokines.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400006

Proposal of a clinical score to stratify the risk of multidrug-resistant gram-negative rods bacteremia in cancer patients
Provedor de dados: 55
Autores: Carena,Alberto A.; Laborde,Ana; Roccia-Rossi,Inés; Palacios,Cynthia J.; Jordán,Rosana; Valledor,Alejandra; Nenna,Andrea; Costantini,Patricia; Dictar,Miguel; Herrera,Fabián.
ABSTRACT  Introduction: Multidrug-resistant gram-negative rods (MDR GNR) represent a growing threat for patients with cancer. Our objective was to determine the characteristics of and risk factors for MDR GNR bacteremia in patients with cancer and to develop a clinical score to predict MDR GNR bacteremia.  Material and Methods: Multicenter prospective study analyzing initial episodes of MDR GNR bacteremia. Risk factors were evaluated using a multiple logistic regression (forward-stepwise selection) analysis including variables with a p &lt; 0.10 in univariate analysis.  Results: 394 episodes of GNR bacteremia were included, with 168 (42.6 %) being MDR GNR. Five variables were identified as independent risk factors: recent antibiotic use (OR = 2.8, 95 % CI...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteremia; Cancer; Multidrug-Resistant gram-negative rods.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100034

Prospective study on the prevention of vertical transmission of HIV in Campo Grande, Mato Grosso do Sul, Brazil, from 1996 to 2001
Provedor de dados: 55
Autores: Dal Fabbro,Márcia Maria Ferrairo Janini; Cunha,Rivaldo Venâncio da; Paniago,Anamaria Mello Miranda; Lindenberg,Andréa de Siqueira C.; Freitas,Gisele Maria Brandão de; Nogueira,Susie Andries.
This prospective study, involving 76 pregnant women infected with HIV, paired with their 79 exposed infants, was carried out between May 1996 and October 2001, at the Reference Department for Pregnant Women Infected with HIV in Campo Grande, Mato Grosso do Sul. The mean age of the pregnant women was 24 years; 88% (67/76) apparently were infected due to sexual practices; 88% (67/76) were housewives; 823% (63/76) graduated from junior high school; 14.5% (11/76) reported co-infection with Hepatitis C, 9.2% with Syphilis; 51% (39/76) learned the diagnosis during prenatal care; 67% (51/76) reported HIV clinical symptomatology and 9.2% (7/76) reported opportunistic infections. Elective cesareans were performed in 57% (43/76). The mean gestational age at delivery...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Certical transmission; Prevention/prophylaxis; Mato Grosso do Sul; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100005

Protease inhibitors and azolic antifungals in HIV patients with histoplasmosis: a clinical pharmacokinetics perspective
Provedor de dados: 55
Autores: Okumura,Lucas Miyake.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400405

Protective effect of metformin against tuberculosis infections in diabetic patients: an observational study of south Indian tertiary healthcare facility
Provedor de dados: 55
Autores: Marupuru,Srujitha; Senapati,Padmanav; Pathadka,Swathi; Miraj,Sonal Sekhar; Unnikrishnan,Mazhuvancherry Kesavan; Manu,Mohan K.
ABSTRACT  Background: World Health Organization estimated that people with diabetes (DM) are at 2-3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes.  Objectives: To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB.  Methods: A case-control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes; Metformin; Tuberculosis prevention.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300312

Protein carbonyl content: a novel biomarker for aging in HIV/AIDS patients
Provedor de dados: 55
Autores: Kolgiri,Vaishali; Patil,Vinayak Wamanrao.
Abstract  Background: The major complications of “treated” Human Immunodeficiency Virus (HIV) infection are cardiovascular disease, malignancy, renal disease, liver disease, bone disease, and perhaps neurological complications, which are phenomena of the normal aging process occurring at an earlier age in the HIV-infected population. The present study is aimed to explore protein carbonyl content as a biomarker for detecting oxidative DNA damage induced ART toxicity and/or accelerated aging in HIV/AIDS patients.  Objective: To investigate the potential of carbonyl content as a biomarker for detecting oxidative Deoxyribonucleic acid (DNA) damage induced Antiretroviral Theraphy (ART) toxicity and/or accelerated aging in HIV/AIDS patients.  Methods: In this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbonyl content; DNA damage; Human immunodeficiency virus (HIV) infection; 8-OH-dG; ROS.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100035

Protein-losing enteropathy in paracoccidioidomycosis identified by scintigraphy: report of three cases
Provedor de dados: 55
Autores: Berni,Aline Dayara de Mendonça; Elias Júnior,Erivaldo; Arão Filho,Adalberto; Paniago,Anamaria Mello Miranda.
Paracoccidioidomycosis (PCM) or South American Blastomycosis is a systemic fungal infection caused by a dimorphic fungus, Paracoccidioides brasiliensis. It represents the most important systemic mycosis in South America and with higher prevalence among male inhabitants of the rural area. PCM usually affects the lungs, and rarely the intestines. The authors report three cases of PCM, treated at the University Hospital of Universidade Federal de Mato Grosso do Sul whose scintigraphy with technetium-99 labeled human albumin revead intestinal protein loss
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Radionuclide imaging; Paracoccidioidomycosis; Intestinal diseases; Technetium Tc99m aggregated albumin.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500020

Pseudomonas aeruginosa infections: factors relating to mortality with emphasis on resistance pattern and antimicrobial treatment
Provedor de dados: 55
Autores: Pinheiro,Millena R.S.; Lacerda,Heloisa R.; Melo,Renata G.L.; Maciel,Mª Amélia.
A retrospective case-control study was conducted to investigate the risk factors for death among intensive care unit patients with Pseudomonas aeruginosa infection. Out of 131 patients investigated, 67 (51.1%) died within 30 days of being diagnosed with this infection. The mean duration of hospital stay before this diagnosis was 28.5 ± 26.5 days. No association was found between bacterial resistance and death in this study (multiresistant p= 0.26; panresistant p= 0.42), but the adequacy of the initial treatment was inversely proportional to the degree of resistance. There was a tendency towards greater mortality among patients who received combination therapy (empirical p= 0.09; definitive p= 0.08), despite the greater frequency of appropriate treatment in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risk factors; Case-control study; Pseudomonas aeruginosa; Death.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600013

Pseudotumoral form of neuroschistosomiasis: report of three cases
Provedor de dados: 55
Autores: Andrade Filho,Antonio S.; Queiroz,Aristidez C.; Freire,Antonio C.C.; Lima,Leonardo Conrado S.; S. Filho,Celso A.; Amado,Isolda N.; Reis,Mittermeyer G.; Magalhães,Isis Fernandes; Carmo,Theomira M.A.
Central nervous system (CSN) involvement in schistosomiasis is an ectopic manifestation with a large variety of clinical forms, including pseudotumoral, which occurs in isolated cases and is rare. Three patients with epidemiological indications of this pathology were examined; the clinical picture included lower-back pain irradiating to lower limbs, associated with progressive flaccid paraparesis and sphincterial disturbances in cases in which the spinal chord was involved; while in cases with encephalitic impairment, headache, dizziness and cerebellar syndrome, characterized by dysarthria and right-side dysgraphia, were present. Magnetic resonance imaging (MRI) showed a growing process in all cases; cerebrospinal fluid (CSF) characteristics and biological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neuroschistosomiasis; Pseudotumoral form; Neuropathology.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400014

Pseudotumoral form of primary progressive tuberculosis: a diagnosis to be considered
Provedor de dados: 55
Autores: Franco,Rosana; Santana,Maria Angélica; Coelho Filho,João Carlos; Pereira-Silva,Jorge L.
The diversity of clinical presentations of primary progressive tuberculosis (TB) and the difficulty in establishing the diagnosis of paucibacillary forms is the subject of painstaking research, as well as a cause of delay in therapy. We report the case of a 10-year-old black child who presented with chest pain and progressive widening of the upper mediastinum. Computerized tomography of the chest revealed multiple calcifications that were not identified with X-rays. Biopsy through mediastinoscopy was compatible with a diagnosis of tuberculosis. Despite exhaustive investigation that included direct examination, culture for mycobacteria and PCR (Polymerase Chain Reaction) of tissue samples, the etiologic agent was not revealed. Tuberculin conversion was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lymph node tuberculosis; Pseudotumoral form; Diagnosis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200011

Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy
Provedor de dados: 55
Autores: Barata,Anna; Malouf,Jorge; Gutierrez,Mar; Mateo,Gracia María; Sambeat,Maria Antònia; Gich,Ignasi; Cadafalch,Josep; Wulff,Juan; Domingo,Pere.
OBJECTIVE: To study whether patients with HIV-1 associated lipodystrophy (LD) on highly active antiretroviral treatment (HAART) have more psychopathology and worse psychosocial adjustment than a similar group without this syndrome. METHODS: In a cross-sectional, observational study we compared 47 HIV-1 infected patients with LD (LD group) with 39 HIV-1 infected patients without LD (non-LD group). All participants were on HAART. The Beck Depression Inventory (BDI), the State and Trait Anxiety Inventory (STAI) and the Goldberg Health Questionnaire (GHQ-60) were administered. Levels of familial, work and social adjustment and adjustment to stressful events were evaluated in a semi-structured interview. Clinical information was extracted from the clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lypodystrophy; Psychopathology; Psychosocial.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400010

Psychosis during peginterferon-alpha2a and ribavirin therapy: case report
Provedor de dados: 55
Autores: Quarantini,Lucas C.; Cruz,Simone Cunha; Batista-Neves,Susana Carolina; Paraná,Raymundo; Miranda-Scippa,Ângela; Bressan,Rodrigo A.
Pegylated Interferon-alpha, combined with ribavirin, gives high sustained virological response in patients with hepatitis C virus, an important public health problem and one of the most frequent chronic infectious diseases worldwide. Though it has therapeutic benefits, treatment with IFN-alpha may be complicated by various side effects, especially symptoms of major depression and acute mania. Psychosis is a rare side effect, and its management usually includes discontinuation of IFN-alpha. We report a case of psychotic disorder that occurred during therapy with pegylated Interferon-alpha given associated with ribavirin. After good response to psychiatric treatment, it became possible to finish the anti-viral therapy.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Interferon-alpha; Hepatitis C; Psychosis.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600010

Pulmonary Alveolar Proteinosis and tuberculosis in a diabetic patient: a rare or a seldom diagnosed association
Provedor de dados: 55
Autores: Pereira-Silva,J.L.; Marinho,M.M.M.A.; Veloso,T.V.B.; Coelho Filho,J.C.
A case of Pulmonary Alveolar Proteinosis (PAP), in association with tuberculosis, is described in a 35-year-old diabetic patient. Lung biopsy showed an intra-alveolar accumulation of PAS-positive material, and multifocal granulomas compatible with tuberculosis. The bronchoalveolar culture was positive for Mycobacterium tuberculosis. PAP results from an imbalance of the mechanisms that regulate the homeostasis of the surfactant, where specific proteins are involved, especially SP-A and SP-D, the cytokines, IL-10 and GM-CSF, in addition to alveolar macrophages and type-II pneumocytes. Chemotaxis and phagocytic capacity are reduced. PAP and diabetes share several immunological disfunctions that may increase the risk for tuberculosis. Although there are no...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary Alveolar Proteinosis (PAP); Tuberculosis; Diabetic patient.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400006

Pulmonary aspergillosis in an immunocompetent patient
Provedor de dados: 55
Autores: Chien,Wei-Lun; Tseng,Jeng-Sen.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300011

Pulmonary cryptococcosis in non-AIDS patients
Provedor de dados: 55
Autores: ,Jin-Quan; Tang,Ke-Jing; Xu,Bing-Ling; Xie,Can-Mao; Light,Richard W.
OBJECTIVE: To investigate the clinical features, management, and prognosis of pulmonary cryptococcosis in non-acquired immunodeficiency syndrome (AIDS) patients. METHOD: 24 cases of pulmonary cryptococcosis with accurate pathological diagnosis were retrospectively studied. RESULTS: 15 male patients and nine female patients were diagnosed at the first affiliated hospital of Sun Yat-sen University from November 1999 to November 2011. The mean age at the time of diagnosis was 44.2 ± 11.3 years (range: 24 to 65 years). Among these patients, 13 had other comorbidities. 15 were symptomatic and the other nine were asymptomatic. The most common presenting symptoms were cough, chest tightness, expectoration, and fever. None had concurrent cryptococcal meningitis....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary cryptococcosis; Clinical presentation; Diagnosis; Treatment; HIV negative.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600006

Purified Protein Derivative - PPD
Provedor de dados: 55
Autores: Sousa,Anastácio Q.; Pompeu,Margarida M.L.; Araujo Filho,C. Jaime; Queiroz,Telma R.B.S.; Ferreira,J. Clementino.
Tipo: Info:eu-repo/semantics/other
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600015

Purple urine bag syndrome in an elderly subject
Provedor de dados: 55
Autores: Bocrie,Olivier-Jacques; Bouchoir,Elodie; Camus,Agnès; Popitean,Laura; Manckoundia,Patrick.
Tipo: Info:eu-repo/semantics/article
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600018

Purpura fulminans: an unusual complication of malaria
Provedor de dados: 55
Autores: Sharma,Alka; Sharma,Vishal.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600015

Pyogenic liver abscess caused by community-acquired multidrug resistance Pseudomonas aeruginosa
Provedor de dados: 55
Autores: Ulug,Mehmet; Gedik,Ercan; Girgin,Sadullah; Celen,Mustafa Kemal; Ayaz,Celal.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300003

qPCR detection of Mycobacterium leprae in biopsies and slit skin smear of different leprosy clinical forms
Provedor de dados: 55
Autores: Azevedo,Michelle de Campos Soriani; Ramuno,Natália Mortari; Fachin,Luciana Raquel Vincenzi; Tassa,Mônica; Rosa,Patrícia Sammarco; Belone,Andrea de Faria Fernandes; Diório,Suzana Madeira; Soares,Cleverson Teixeira; Garlet,Gustavo Pompermaier; Trombone,Ana Paula Favaro.
Abstract Leprosy, whose etiological agent is Mycobacterium leprae, is a chronic infectious disease that mainly affects the skin and peripheral nervous system. The diagnosis of leprosy is based on clinical evaluation, whereas histopathological analysis and bacilloscopy are complementary diagnostic tools. Quantitative PCR (qPCR), a current useful tool for diagnosis of infectious diseases, has been used to detect several pathogens including Mycobacterium leprae. The validation of this technique in a robust set of samples comprising the different clinical forms of leprosy is still necessary. Thus, in this study samples from 126 skin biopsies (collected from patients on all clinical forms and reactional states of leprosy) and 25 slit skin smear of leprosy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium leprae; QPCR; Leprosy; Bacilloscopy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100071

Quality of antenatal care as a risk factor for early onset neonatal infections in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Mizumoto,B.R.; Moreira,B.M.; Santoro-Lopes,G.; Cunha,A.J.; Santos,R.M.R. dos; Pessoa-Silva,C.L.; Pinheiro,Azeredo A.N.; Ferreira,M.; Leobons,M.B.; Hofer,Cristina Barroso.
Background: Neonatal infection is a serious public health problem. The aim of this study was to assess the influence of the antenatal care on the risk of early-onset neonatal healthcare associated infection in two Brazilian maternities.Methods: Cohort study - Newborns admitted at two public neonatal intensive care units from 2008 to 2009 were included in the study. Data on antenatal and perinatal variables were collected from maternal prenatal cards and medical charts. Newborns were actively surveyed for early-onset neonatal healthcare associated infection, defined as a neonatal infection diagnosed within 48 h after birth. Multiple logistic regression was used to assess variables independently associated with early-onset neonatal healthcare associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Early-onset healthcare associated infections; Antenatal care; Newborn; Public maternity.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300272

Quality of life and pain multidimensional aspects in individuals with HTLV-1
Provedor de dados: 55
Autores: Macêdo,Maíra Carvalho; Mota,Renata de Sousa; Patrício,Naiane Araújo; Santos,Ana Paula Campos dos; Mendes,Selena Márcia Dubois; Dias,Cristiane Maria Carvalho Costa; Baptista,Abrahão Fontes; Sá,Katia Nunes.
Abstract HTLV-1 creates a chronic health condition that involves moderate to severe pain with a negative impact on quality of life (QoL). There is no consensus on which attitudes to pain are more related to the worsening of QoL in HTLV-1 infected patients. The aim of this study was to investigate the correlation between QoL and multidimensional aspects of pain in patients with HTLV-1. A cross-sectional study was conducted in Salvador, Bahia, Brazil. The study included individuals diagnosed with HTLV-1. The Short Form 36 Questionnaire was used to analyze QoL, and the Brief Pain Inventory was used to assess multidimensional aspects of pain. The mean pain intensity was 4.88 ± 3.06 on the visual pain scale, and the average impact on QoL corresponded to a loss...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Pain; Quality of life; HTLV-1.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500494

Quality of life, anxiety and depression in patients with HIV/AIDS who present poor adherence to antiretroviral therapy: a cross-sectional study in Salvador, Brazil
Provedor de dados: 55
Autores: Betancur,Mónica Narváez; Lins,Liliane; Oliveira,Irismar Reis de; Brites,Carlos.
Abstract The introduction of highly active antiretroviral therapy marked a major gain in efficacy of HIV/AIDS treatment and a reduction in morbidity and mortality of the infected patients. However, high levels of adherence are required to obtain virologic suppression. In Brazil, the policy of free and universal access to antiretroviral therapy has been in place since 1996, although there are reports of poor adherence.  Objective To define the clinical, demographic and psychological characteristics, and quality of life of patients with HIV/AIDS who present poor adherence to highly active antiretroviral therapy.  Methods This was a cross-sectional study. To be included in the study patients had to be 18 through 65 years old, diagnosed with HIV/AIDS, having...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Highly active antiretroviral therapy; HIV/AIDS; Adherence; Nonadherence; Anxiety; Depression; Quality of life.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500507

Quality of life, risk behaviors and depression among carriers of hepatitis C virus and human T-cell lymphotropic virus type 1: a comparative study
Provedor de dados: 55
Autores: Henrique-Araújo,Ricardo; Quarantini,Lucas C.; Caribé,André C.; Argolo,Felipe C.; Jesus-Nunes,Ana Paula; Morais-de-Jesus,Mychelle; Dantas-Duarte,Adriana; Moreira,Tayne Miranda; Oliveira,Irismar Reis de.
Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) has low prevalence rates, but is endemic in some regions of the world. It is usually a chronic asymptomatic infection, but it can be associated with serious neurologic and urinary conditions. Hepatitis C virus (HCV) is broadly spread out worldwide. The majority of these infections have a chronic course that may progress to cirrhosis and hepatocellular carcinoma.  Objectives: To compare sociodemographic and mental health (risk behaviors, depression, and suicide) aspects, and quality of life among patients with HCV or HTLV-1.  Methods: Observational, comparative and cross-sectional study involving outpatients with HCV or HLTV-1 infection. Sociodemographic characteristics, risk behaviors and quality of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C virus; Human T-cell lymphotropic virus type 1; Quality of life; Risk behaviors; Depression; Suicide.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400224

Quality of sputum in the performance of polymerase chain reaction for diagnosis of pulmonary tuberculosis
Provedor de dados: 55
Autores: Silva,Rosemeri Maurici da; Bazzo,Maria Luiza; Chagas,Mariana.
SETTING: faster alternative techniques are required to improve the diagnosis and control of pulmonary tuberculosis. OBJECTIVE: To evaluate the sample quality in the performance of PCR for diagnosis of pulmonary tuberculosis. METHOD: during one year, sputum samples were collected from 72 pulmonary tuberculosis patients and 12 non-tuberculosis controls, which were admitted to the Nereu Ramos hospital, Florianópolis city, Brazil. The samples were subjected to Ziehl-Neelsen-stained sputum smear microscopy and Lowestein-Jensen medium culture, which were defined as gold standard tests for mycobacteria, and polymerase chain reaction (PCR). Those samples that presented more than 40% of viable cells and less than 25% of epithelial cells were defined as high quality...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Tuberculosis; Sputum; Polymerase chain reaction.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100022

Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Provedor de dados: 55
Autores: Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Nascimento,Margareth Tavares Silva; Gomes,Andreza de L.S.
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Falciparum malaria; Quinine; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500001

Quinolone-resistant Escherichia coli
Provedor de dados: 55
Autores: Ito,Carmen Antonia Sanches; Gales,Ana Cristina; Tognim,Maria Cristina B.; Munerato,Patrícia; Dalla Costa,Libera Maria.
Quinolones (nalidixic acid - NAL, norfloxacin - NOR, ciprofloxacin - CIP and gatifloxacin - GAT) were tested against Escherichia coli isolated from urine (385 patient samples) by disk diffusion (DD) and agar dilution (AD) methods. Fifty-three samples (13.8%) were classified as resistant to at least one of the quinolones tested. CIP and NOR susceptibilities were the same (91.4%) and they were similar to GAT (92.7%). Susceptibility to NAL, detected by the disk diffusion method, was used to predict susceptibility to NOR, CIP and GAT by the agar dilution method. The sensitivity and specificity of NAL were 100% and 95%, respectively. Twelve samples were analyzed for mutations in the quinolone resistance-determining region (QRDR) of the gyrA and parC genes....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Urinary infection; Quinolone resistance; Escherichia coli.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100003

Rabies in humans and non-human in the state of Pará, Brazilian Amazon
Provedor de dados: 55
Autores: Fernandes,Marcus Emanuel Barroncas; Costa,Lanna Jamile Corrêa da; Andrade,Fernanda Atanaena Goncalves de; Silva,Lucila Pereira.
We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p &lt; 0.01), but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazilian Amazon; Humans and non-humans; Lyssavirus; Rabies.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200020

Radiologic findings of pulmonary tuberculosis in adolescents
Provedor de dados: 55
Autores: Sant'Anna,Clemax Couto; Schmidt,Christianne Mello; March,Maria de Fátima B Pombo; Pereira,Susan Martins; Barreto,Maurício Lima.
OBJECTIVE: To describe radiologic findings of pulmonary tuberculosis (TB) in adolescents. METHODS: Retrospective, cross-sectional, observational study of 850 patients with TB, aged 10 to 19 years, and notified to the Brazilian Ministry of Health. Data were collected from the TB notification and medical records in the cities of Manaus, Amazonas State, and Salvador, Bahia State, in the 19962003 period. Data are shown in tables and analyzed using the chi-square and Mann-Whitney tests, with a 5% significance level. RESULTS: Mean age was 15.6 years; 443 (52.1%) patients were males. The most common radiologic lesion was the upper pulmonary lobe infiltrate (53.3%), and isolated cavitation was found in 32.4% of the patients. Both lungs were affected in 29.2% of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Adolescents; Diagnosis; Chest radiography.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100008

Ralstonia pickettii sepsis in a hemodialysis patient from Bulgaria
Provedor de dados: 55
Autores: Strateva,Tanya; Kostyanev,Tomislav; Setchanova,Lena.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400019

Raoultella ornithinolytica causing fatal sepsis
Provedor de dados: 55
Autores: Kaya,Selçuk; Bayramoglu,Gülçin; Sönmez,Mehmet; Köksal,Iftihar.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200230

Rapid detection of Vancomycin-Resistant Enterococci (VRE) in rectal samples from patients admitted to intensive care units
Provedor de dados: 55
Autores: d'Azevedo,Pedro Alves; Santiago,Kelly Aline de Souza; Furtado,Guilherme Henrique Campos; Xavier,Diego Batista; Pignatari,Antonio Carlos Campos; Titze-de-Almeida,Ricardo.
The reduction in time required to identify vancomycin-resistant enterococci (VRE) has gained increased importance during hospital outbreaks. In the present study, we implemented a laboratory protocol to speed up the VRE screening from rectal samples. The protocol combines a medium for selective VRE isolation (VREBAC®, Probac, São Paulo) and a multiplex PCR for detection and identification of vanA and vanB resistance genes. The screening performance was analyzed in 114 specimens collected from four intensive care units. The swabs were collected at two periods: (1) during a VRE outbreak (February 2006, n=83 patients) and (2) at the post-outbreak period, after adoption of infection control measures (June 2006, n=31 patients). Forty-one/83 VRE (49.4%) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enterococcus; VRE; Vancomycin; Diagnostic; PCR.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400010

Rapid diagnosis of community-acquired pneumonia using the Bac T/ alert 3D system
Provedor de dados: 55
Autores: Capoor,Malini R.; Nair,Deepthi; Aggarwal,Pushpa; Gupta,B.
We compared BacT/Alert 3D with conventional culture for the diagnosis of community-acquired pneumonia (CAP). Antimicrobial susceptibility testing of the isolates was performed with the disk diffusion method, and the minimum inhibitory concentration (MIC) was calculated. Automation was superior in terms of recovery and time to detect pathogens. The bacterial spectrum in CAP was Streptococcus pneumoniae (35.3%) Staphylococcus aureus (23.5%), Klebsiella pneumoniae (20.5%) and Haemophilus influenzae (8.8%). Three of the 12 S. pneumoniae isolates showed penicillin resistance on MIC and two showed erythromycin resistance. There were two H. influenzae strains resistant to penicillin; these were beta lactamase producers. One-fourth of the S. aureus were oxacillin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community-acquired pneumonia; Streptococcus pneumoniae; Cefepime.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500010

Rapid spread of an ongoing outbreak of Zika virus disease in pregnant women in a Mexican hospital
Provedor de dados: 55
Autores: Garza-González,Elvira; Mendoza-Olazarán,Soraya; Roman-Campos,Raúl; Téllez-Marroquín,Ricardo; Saldívar-Rodríguez,Donato; Soria-López,Juan A.; Guzman,Abel; Flores-Treviño,Samantha; Camacho-Ortiz,Adrián.
Abstract In the first nine weeks of implementation of a Zika Virus Preparedness Plan in a Mexican Public Hospital, we cared for 221 pregnant women with any signal or symptom suggesting Zika virus infection and 99 (44.8%) patients were found to be positive for Zika virus.The median age of patients was 25.3 years (range 13-49). Symptoms in PCR-positive patients were rash (91.4%) followed by headache (53.1%), myalgia (46.9%), arthralgia (45.7%), pruritus (35.8%), retroocular pain (29.6%), conjunctivitis (21%), and fever (21%). The women's epidemiologic exposure history indicates local transmission and a community outbreak.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Zika virus disease; Congenital Zika virus syndrome; Microcephaly.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500554

Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia
Provedor de dados: 55
Autores: Karapinar,Deniz Yilmaz; Karadas,Nihal; Sivis,Zühal Önder; Yazici,Pinar; Duyu,Muhterem; Metin,Dilek; Karapinar,Bülent; Aydinok,Yeşim.
ABSTRACTEmpirical antifungal therapy is most often given to patients with leukemia. However breakthrough fungal infections under antifungal therapy are not uncommon. Four children, with hematologic malignant disease developed mycotic breakthrough infections while on empirical caspofungin treatment for a median of 14 (range 11-19) days. Trichosporon asahii was detected in the blood culture of two patients and Geotrichum capitatum in the other two (one patient also had positive cerebrospinal fluid culture). Because the patients' clinical situation worsened, voriconazole was empirically added for two patients three and five days before the agent was detected. The first sterile blood culture was obtained 3-7 days of voriconazole treatment. All patients reached...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Geotrichum capitatum; Trichosporon asahii; Invazive fungal infection; Febrile neutropenia.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500549

Rare zoonosis (hemotrophic mycoplasma infection) in a newly diagnosed systemic lupus erythematosus patient followed by a Nocardia asteroides pneumonia
Provedor de dados: 55
Autores: Bosnic,Dubravka; Baresic,Marko; Anic,Branimir; Sentic,Mirna; Cerovec,Mislav; Mayer,Miroslav; Cikes,Nada.
Systemic lupus erythematosus (SLE) is per se a disease characterized by suppressed immune response and thus susceptibility to various opportunistic infections. We describe the case of a 21-yearold woman who developed a rare zoonosis - hemotrophic mycoplasma infection in the initial stage of SLE, complicated with Nocardia asteroides pneumonia afterwards. Nocardia infection coincided with initiation of glucocorticoids and cyclophosphamide therapy for SLE. After the treatment she recovered completely. To our knowledge the only case of human hemoplasmosis (then referred to as eperythrozoonosis) in medical literature was the one described by a group of Croatian authors 22 years ago. No cases of a hemotrophic mycoplasma infection in a SLE patient have been...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: SLE; Zoonosis; Hemotrophic mycoplasma (hemoplasma); Eperythrozoon; Nocardia asteroides.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100019

Rate and time to develop first central line-associated bloodstream infections when comparing open and closed infusion containers in a Brazilian Hospital
Provedor de dados: 55
Autores: Vilins,Margarete; Blecher,Sergio; Silva,Maria A. Maretti da; Rosenthal,Victor Daniel; Barker,Kerry; Salomao,Reinaldo.
The objective of the study was to determine the effect of switching from an open (glass or semi-rigid plastic) infusion container to a closed, fully collapsible plastic infusion container (Viaflex®) on rate and time to onset of central lineassociated bloodstream infections (CLABSI). An open-label, prospective cohort, active healthcare-associated infection surveillance, sequential study was conducted in three intensive care units in Brazil. The CLABSI rate using open infusion containers was compared to the rate using a closed infusion container. Probability of acquiring CLABSI was assessed over time and compared between open and closed infusion container periods; three-day intervals were examined. A total of 1125 adult ICU patients were enrolled. CLABSI...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteremia; Central line-associated blood stream infections; Intensive care unit; Healthcare-associated infection; Intravascular device.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500004

Rates of antimicrobial resistance in latin america (2004-2007) and in vitro activity of the glycylcycline tigecycline and of other antibiotics
Provedor de dados: 55
Autores: Rossi,Flávia; García,Patricia; Ronzon,Bernardo; Curcio,Daniel; Dowzicky,Michael J.
As a part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.), Gram-positive and Gram-negative bacterial isolates were collected from 33 centers in Latin America (centers in Argentina, Brazil, Chile, Colombia, Guatemala, Honduras, Jamaica, Mexico, Panama, Puerto Rico, and Venezuela) from January 2004 to September 2007. Argentina and Mexico were the greatest contributors of isolates to this study. Susceptibilities were determined according to Clinical Laboratory Standards Institute guidelines. Resistance levels were high for most key organisms across Latin America: 48.3% of Staphylococcus aureus isolates were methicillin-resistant while 21.4% of Acinetobacter spp. isolates were imipenem-resistant. Extended-spectrum β-lactamase were reported in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial resistance; Latin America; Tigecycline; Surveillance.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500012

Ratio of monocytes to lymphocytes in peripheral blood in patients diagnosed with active tuberculosis
Provedor de dados: 55
Autores: Wang,Jun; Yin,Yongmei; Wang,Xuedong; Pei,Hao; Kuai,Shougang; Gu,Lan; Xing,Huiqin; Zhang,Yu; Huang,Qiusheng; Guan,Bin.
Objective: The ratio of monocytes to lymphocytes in peripheral blood could reﬂect an indi- vidual's immunity to Mycobacterium tuberculosis . The objective of this study was to evaluate the relationship between ratio of monocytes to lymphocytes and clinical status of patients with active tuberculosis.  Methods: This was a retrospective review of data collected from the clinical database of The Fifth People's Hospital of Wuxi, Medical College of Jiangnan University. A total of 419 patients who had newly diagnosed active tuberculosis and 108 cases from 419 patients with tuberculosis therapy either near completion or completed were selected. Controls were 327 healthy donors.  Results: Median ratio of monocytes to lymphocytes was 0.36 (IQR, 0.22-0.54) in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Active tuberculosis Monocytes Lymphocytes; ML ratio.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200125

Rational design of diagnostic and vaccination strategies for tuberculosis
Provedor de dados: 55
Autores: Borsuk,Sibele; Seixas,Fabiana Kommling; Ramos,Daniela Fernandes; Mendum,Tom; McFadden,Johnjoe; Dellagostin,Odir.
The development of diagnostic tests which can readily differentiate between vaccinated and tuberculosis-infected individuals is crucial for the wider utilization of bacillus Calmette-Guérin (BCG) as vaccine in humans and animals. BCG_0092 is an antigen that elicits specific delayed type hypersensitivity reactions similar in size and morphological aspects to that elicited by purified protein derivative, in both animals and humans infected with the tubercle bacilli. We carried out bioinformatics analyses of the BCG_0092 and designed a diagnostic test by using the predicted MHC class I epitopes. In addition, we performed a knockout of this gene by homologous recombination in the BCG vaccine strain to allow differentiation of vaccinated from infected...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Gene knockout techniques; Clinical diagnosis; BCG vaccine.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100012

Raw oysters can be a risk for infections
Provedor de dados: 55
Autores: Vieira,Regine Helena Silva dos Fernandes; Sousa,Oscarina Viana de; Costa,Renata Albuquerque; Theophilo,Grace Nazareth Diogo; Macrae,Andrew; Fonteles Filho,Antonio Adauto; Rodrigues,Dália dos Prazeres.
The aims of this study were to count and identify sucrose positive and negative vibrios isolated from cultivated Crassostrea rhizophorae oysters during their growing cycle. Every month for 12 months, 10 to 18 oysters were collected for study. Collections occurred at the Center for Studies of Coastal Aquaculture (CSCA), which is associated with the Institute of Marine Science, Labomar, located in Euzebio, Ceará, Brazil. Approximately 150 oysters and their intervalvular liquor were studied. Vibrio Standard Plates Counts (SPC) from oyster meat and their intervalvular liquor varied from 25 to 59,000,000 CFU/g. For most of the 12 months of the oysters' life, it was possible to identify Vibrio parahaemolyticus. Vibrio carchariae was identified in four...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vibrio spp; Oyster; Public health; Vibrio parahaemolyticus; Vibrio carchariae.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100013

Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome
Provedor de dados: 55
Autores: Santos,Eder de Oliveira; Canela,João dos Reis; Monção,Henry Carlos Gomes; Roque,Mauro José Guedes.
Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Chagas' disease; Trypanosoma cruzi; Acquired immunodeficiency syndrome; Human immunodeficiency virus; Meningoencephalitis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600009

Reading and interpretation of chest X-ray in adults with community-acquired pneumonia
Provedor de dados: 55
Autores: Moncada,Diana Carolina; Rueda,Zulma Vanessa; Macías,Antonio; Suárez,Tatiana; Ortega,Héctor; Vélez,Lázaro Agustín.
INTRODUCTION: Traditional reading of chest X-rays usually has a low prognostic value and poor agreement. OBJECTIVE: This study aimed to determine the interobserver and intraobserver agreement using two reading formats in patients with community-acquired pneumonia, and to explore their association with etiology and clinical outcomes. METHODS: A pulmonologist and a radiologist, who were blind to clinical data, interpreted 211 radiographs using a traditional analysis format (type and location of pulmonary infiltrates and pleural findings), and a quantitative analysis (pulmonary damage categorized from 0 to 10). For both, the interobserver and intraobserver agreement was estimated (Kappa statistic and intraclass correlation coefficient). The latter was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Radiography; Thoracic pneumonia reproducibility of results.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600007

Recent HCV genotype changing pattern in the Khyber Pakhtunkhwa province of Pakistan; is it pointing out a forthcoming problem?
Provedor de dados: 55
Autores: Afzal,Muhammad Sohail; Shah,Zaheer Hussain; Ahmed,Haroon.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300018

Recent HIV infection rates among HIV positive patients seeking voluntary counseling and testing centers in the metropolitan region of Recife - Pe, Brazil
Provedor de dados: 55
Autores: Cavalcanti,Ana Maria Salustiano; Brito,Ana Maria de; Salustiano,Daniela Medeiros; Lima,Kledoaldo Oliveira de; Silva,Sirleide Pereira da; Lacerda,Heloisa Ramos.
The BED capture enzyme immunoassay test makes it possible to determine whether individuals were recently infected with HIV. OBJECTIVE: In this study, the overall HIV and recent infections prevalences were determined at five Voluntary Counseling and Testing (VCT) centers, in the Metropolitan Region of Recife, Northeastern of Brazil. MATERIAL AND METHODS: A cross-sectional study was conducted among users of five VCTs in the metropolitan region of Recife between July 2007 and April 2009. Out of the individuals who tested positive for HIV, 169 were analyzed to assess the prevalence of recent infection by means of the BED-CEIA (BED-Calypte®). RESULTS: Out of 46,696 individuals tested 916 (1.96%) turned out positive for HIV infection The highest prevalence was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HIV seroprevalence; Seroepidemiologic studies; HIV infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200009

Receptor expression and responsiveness of human peripheral blood mononuclear cells to a human cytomegalovirus encoded CC chemokine
Provedor de dados: 55
Autores: Zheng,Qi; Xu,Jun; Gao,Huihui; Tao,Ran; Li,Wei; Shang,Shiqiang; Gu,Weizhong.
Human cytomegalovirus is a ubiquitous pathogen that infects the majority of the world's population. After long period of time co-evolving with human being, this pathogen has developed several strategies to evade host immune surveillance. One of the major trick is encoding homologous to those of the host organism or stealing host cellular genes that have signiﬁcant functions in immune system. To date, we have found several viral immune analogous which include G protein coupled receptor, class I major histocompatibility complex and chemokine. Chemokine is a small group of molecules which is deﬁned by the presence of four cysteines in highly conserved region. The four kinds of chemokines (C, CC, CXC, and CX3C) are classiﬁed based on the arrangement of 1 or 2...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chemokine; Cytomegalovirus; Receptor; Immune.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400403

Recommendations for hygiene of masks and circuits in mechanically home ventilated patients
Provedor de dados: 55
Autores: Toussaint,Michel; Reychler,Gregory.
Home mechanical ventilation requires equipment, consisting of a generator of pressure, a tubing and an interface to deliver air to the patient. Instructions for equipment maintenance are generally not based on scientific evidence. Studies however have reported that tubing and masks used at home are the most commonly found as very dirty and contaminated. Dirtiness and contamination of equipment potentially expose patients to a higher risk of airway colonization, which, in turn, should cause respiratory infections. For this reason, published hygiene instructions include the use of disinfectant solution. Nevertheless, they generally fail to explain how basic maintenance may be achieved by simple cleaning with soap and water. The instructions for post-cleaning...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Contamination; Colonization; Disinfection; Home mechanical ventilation; Hygiene; Maintenance; Non-invasive ventilation.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400013

Recommendations for outpatient parenteral antimicrobial therapy in Brazil
Provedor de dados: 55
Autores: Oliveira,Priscila R.; Carvalho,Vladimir C.; Cimerman,Sergio; Lima,Ana Lucia Munhoz.
ABSTRACT A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to determine the recommendations for outpatient parenteral antimicrobial therapy (OPAT) in Brazil. The following aspects are covered in the document: organization of OPAT programs; patient evaluation and eligibility criteria, including clinical and sociocultural factors; diagnosis of eligibility; venous access and antimicrobial infusion devices; protocols for antimicrobial use and monitoring and cost-effectiveness.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Therapy; Outpatient infusion; Health planning recommendations; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600648

Recommendations for the treatment of osteomyelitis
Provedor de dados: 55
Autores: Lima,Ana Lucia L.; Oliveira,Priscila R.; Carvalho,Vladimir C.; Cimerman,Sergio; Savio,Eduardo.
With the advances in surgical treatment, antibiotic therapy and the current resources for accurate diagnosis and differentiated approaches to each type of osteomyelitis, better results are being obtained in the treatment of this disease. After a careful literature review carried out by a multiprofessional team, some conclusions were made in order to guide medical approach to different types of osteomyelitis, aiming to obtain better clinical outcomes and reducing the social costs of this disease. Acute and chronic osteomyelitis are discussed, with presentation of the general epidemiological concepts and the commonly used classification systems. The main guidelines for the clinical, laboratory and imaging diagnosis of infections are discussed, as well as the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteomyelitis; Bone and joint infection; Soft tissue infection; Infectious diseases.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500526

Record linkage and capture-recapture estimates for underreporting of human leptospirosis in a Brazilian health district
Provedor de dados: 55
Autores: Brum,Liane; Kupek,Emil.
Record linkage and capture-recapture models were used to estimate the number of cases of human leptospirosis in the health district of Santa Maria, RS in southern Brazil. Twelve months of laboratory, hospital and epidemiological surveillance data were matched by name, age, residence and the month of diagnosis. Only laboratory-confirmed cases were considered. The record linkage revealed more than 20 times more cases than the official estimate for the health district, indicating a leptospirosis epidemic, with an annual incidence of more than 3 per 1,000 inhabitants and a case fatality of 0.37%. Severe cases were predominantly found through hospital records, overlapping to some extent with the epidemiological surveillance data, whereas less severe cases were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Record linkage; Capture-recapture; Log-linear models; Reporting bias.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600011

Recurrent pneumonia caused by genetic immunodeficiency: a prophylactic and rehabilitative approach
Provedor de dados: 55
Autores: Leal,Renata Cristina de Angelo Calsaverini; Bertelli,Érika Cristina Pavarino; Soler,Zaida Aurora Sperli Geraldes.
Recurrent infections are a consequence of a series of genetic diseases characterized by deficiency in the immunological response. One of these diseases is the agammaglobulinemia, which is characterized by the basic defect in the maturation of lymphocytes B. The carrier of this kind of immunodeficiency, which is linked to the X (XLA) chromosome, has had primary pneumonias that have evolved into secondary pneumonias (chronic lungs with sequelae) after the third or fourth year of life. The clinical and rehabilitative quest for prophylaxis against the XLA immunodeficiency is accomplished in order to avoid the evolution of the bacterial infection into sequelae and loss of pulmonary function, which propitiates the recurrence of the disease and deteriorates the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Immunodeficiency; Physiotherapy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300001

Recurrent pulmonary mucormycosis after lobectomy in a non-smoking patient without predisposing risk factors
Provedor de dados: 55
Autores: Zhang,Lu; Tian,Xinlun; Wang,Peng; Zhang,Hong; Feng,Ruie.
Pulmonary mucormycosis is a very rare clinical condition in patients without underlying risk factors. A limited number of cases have been reported in predominantly elderly patients; history of smoking appears to be a common feature. A case of non-smoking male who developed pulmonary mucormycosis with the longest reported follow-up is presented. In addition, this is also the first reported case with disease recurrence after lobectomy (two years) in an immunocompetent host. Treatment with an additional lobectomy and amphotericin B was successful in this patient.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Pulmonary mucormycosis; Predisposing risk factor.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600016

Recurring Candida albicans esophagitis in a HIV-infected patient undergoing long-Term antiretroviral therapy, and with absent-negligible immunodeficiency
Provedor de dados: 55
Autores: Manfredi,Roberto; Sabbatani,Sergio; Calza,Leonardo.
A patient with HIV infection developed the first episode of AIDS-defining opportunism (severe Candida albicans esophagitis) with an underlying CD4+ lymphocyte count of 1,025 cells/µL. After treatment with a highly active antiretroviral therapy (HAART), taken with insufficient compliance and leaving a residual viral load, our patient suffered from two relapses of esophageal candidiasis, which occurred three months and seven years later, when his CD4+ lymphocyte count was 930 and 439 cells/µL, respectively, and a viral load slightly above 10(4) copies/mL was still present. Also in the HAART era, Candida esophagitis remains one of the most common AIDS-defining diseases, but a presentation with a concurrent CD4+ count above 1,000 cells/µL remains a rare...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Esophageal candidiasis; HIV infection; CD4+ lymphocyte count; HIV viral load; Recurring opportunistic disease; Antiretroviral therapy; Negligible or absent immunodeficiency.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600016

Re-emergence of human T-lymphotropic viruses in West Africa
Provedor de dados: 55
Autores: Anyanwu,Nneoma Confidence JeanStephanie; Ella,Elijah Ekah; Ohwofasa,Aghogho; Aminu,Maryam.
ABSTRACT Human T-lymphotropic viruses (HTLV) are Deltaretroviruses that infect millions of individuals worldwide via the same transmission routes as HIV. With the aim of exposing the possible re-emergence of HTLV in West Africa since discovery, a systematic review was carried out, focusing on the distribution of the virus types and significance of frequent indeterminate reports, while highlighting the need for mandatory routine blood screening. Capturing relevant data from discovery till date, sources searched were Google Scholar, CrossRef, NCBI (PubMed), MEDLINE, Research Gate, Mendeley, abstracts of Conferences and Proceedings, organization websites and reference lists of selected papers. A total of 2626 references were initially retrieved using search...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV in West Africa; Worldwide distribution; Epidemiology; HAM/TSP; Seroindeterminate individuals; Blood transfusion; ATLL.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300224

Reemergence of measles in Bulgaria: a large outbreak in Plovdiv, 2010
Provedor de dados: 55
Autores: Vatev,Nikolay Todorov; Stoycheva,Mariana Vartigova; Petrov,Andrey Ivanov.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600021

Reference range for T lymphocytes populations in blood donors from two different regions in Brazil
Provedor de dados: 55
Autores: Torres,A.J.L.; Angelo,A.L.D.; Netto,E.M.; Sampaio,G.P.; Souza,D.F.C.; Inocêncio,L.A.; Lemos,J.A.R.; Brites,C.
This study defined the normal variation range for different subsets of T-lymphocyte cells count in two different Brazilian regions. We analysed the T-lymphocytes subpopulations (CD3+, CD4+, CD8+) in blood donors of two Brazilian cities, located in North (Belem, capital state of Para, indian background) and Northeast (Salvador, capital state od Bahia, African background) regions of Brazil. Results were compared according to gender, stress level (sleep time lower than 8 hours/day), smoking, and alcohol intake. Lymphocytes subpopulations were measured by flow cytometry. Five hundred twenty-six blood donors from two Brazilians cities participated in the study: 450 samples from Bahia and 76 samples from Pará. Most (60%) were men, 59% reported alcohol intake,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CD4; CD8; Blood donors; Reference values; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300013

Regional patterns of the temporal evolution of the AIDS epidemic in Brazil following the introduction of antiretroviral therapy
Provedor de dados: 55
Autores: Brito,Ana Maria de; Castilho,Euclides Ayres de; Szwarcwald,Célia Landmann.
We examined the characteristics of the AIDS epidemic in the northeastern region of Brazil, comparing it to the epidemic in Brazil as a whole, and to the state of São Paulo, with respect to the temporal evolution of morbidity and mortality during the period 1990 to 1999, using information from communicable disease reports and mortality records. Since 1996, the incidence rate of AIDS in adults in Brazil as a whole and in São Paulo has been showing a trend towards stability, whereas in the Brazilian northeast the incidence rates of the disease continue to grow. In the northeast, sexual transmission is responsible for more than 80% of cases, injectable drug users (IDU) comprising only a small percentage of cases. There is a greater incidence of AIDS among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS/morbidity; AIDS/mortality; Temporal trend; Antiretroviral therapy; Brazil; Northeastern region.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100004

Reiter's Syndrome associated with the Acquired Immunodeficiency Syndrome: a case report
Provedor de dados: 55
Autores: Malta,J.B.N.S.; Milanelo,D.; Carvalheiro,F.A.R.; Silva,M.V.
The association of Reiter's Syndrome (RS) with the Acquired Immunodeficiency Syndrome (AIDS) is seldom mentioned in the medical literature. This report illustrates this relationship in a 46 years old male patient suffering from AIDS (CD4+ = 240 cells/mm³, CD8+ = 1,301 cells/mm³ and viral load = 330,000 copies/ml), pulmonary tuberculosis (positive catarrhal bacilluscopy), and RS. The diagnosis of RS was based on the combination of dermatological and articular alterations. The patient's cutaneous lesions were characterized by exfoliation and the formation of crusts located on the face, scalp, genitals, hands, and feet; onychodystrophy with opacity; yellowish coloring; and hyperkeratosis of the nails. Articular lesions led to progressive deformity of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Reiter's syndrome; Acquired immunodeficiency syndrome; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100006

Related factors to atazanavir plasma levels in a cohort of HIV positive individuals with undetectable viral load
Provedor de dados: 55
Autores: Luz,Ana Júlia; Poeta,Júlia; Linden,Rafael; Antunes,Marina Venzon; Caminha,Luiza Isola; Sprinz,Eduardo.
OBJECTIVE: To evaluate the factors associated with plasma concentrations of atazanavir (ATV) in a cohort of well-controlled HIV infected subjects (undetectable viremia). Design: Cross-sectional study where 69 subjects were consecutively enrolled between April and November, 2011. METHODS: Patients had to be on atazanavir for at least six months, undetectable viral load for a period equal to or longer than 12 months, T CD4+ lymphocyte count higher than 200 cells/mm³, and aged between 18 years and 70 years old. Exclusion criteria were pregnancy, any neurologic disease, active opportunistic disease, hepatitis or cancer. Atazanavir plasma levels were measured by ultra-performance liquid chromatography. RESULTS AND DISCUSSION: Overall, 54 patients (mean age of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Atazanavir; Plasma levels; Drug concentration; Ritonavir; Lipid profile.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600006

Relationship between climatic factors and air quality with tuberculosis in the Federal District, Brazil, 2003-2012
Provedor de dados: 55
Autores: Fernandes,Fernanda Monteiro de Castro; Martins,Eder de Souza; Pedrosa,Daniella Melo Arnaud Sampaio; Evangelista,Maria do Socorro Nantua.
Abstract  Introduction: Despite the high rate of tuberculosis indicators in Brazil, the Federal District shows a low prevalence of the disease.  Objective: To analyze the relationship between climatic factors and air quality with tuberculosis in the Brazilian Federal District.  Methodology: This was an ecological and descriptive study comparing 3927 new cases of Tuberculosis registered at the Federal District Tuberculosis Control Program with data from the National Institute of Meteorology, Brazilian Institute of Geography and Statistics, Brazilian Agricultural Research Institute, Brasilia Environmental Institute, and the Federal District Planning Company.  Results: From 2003 to 2012, there has been a higher incidence of Tuberculosis (27.0%) in male...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Seasonality; Air pollution.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400369

Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America
Provedor de dados: 55
Autores: Duarte,Horacio A.; Harris,Donald Robert; Tassiopoulos,Katherine; Leister,Erin; Negrini,Silvia Fabiana Biason de Moura; Ferreira,Flávia Faleiro; Cruz,Maria Letícia Santos; Pinto,Jorge; Allison,Susannah; Hazra,Rohan.
Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of human immunodeficiency virus-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach to account for possible correlations in outcomes measured repeatedly in the same participants. Associations of adherence with human immunodeficiency virus viral load were examined using linear regression. Mean enrollment age...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pediatric; ART; Adherence; Latin America.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300263

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST
Provedor de dados: 55
Autores: Santos,Eliana Abreu; Gonçalves,José Carlos Saraiva; Fleury,Marcos K.; Kritski,Afrânio L.; Oliveira,Martha M.; Velasque,Luciane S.; Silva,José Roberto Lapa e; Estrela,Rita de Cássia E.
ABSTRACT  Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH.  Objective: To characterize the genetic polymorphisms of CYP2E1, GSTT1 and GSTM1 in TB carriers.  Design: This is an observational prospective cohort study of 45 patients undergoing treatment of TB. PCR-RFLP and multiplex-PCR were used.  Results: The distribution of genotypic frequency in the promoter region (CYP2E1 gene) was: 98% wild genotype and 2% heterozygous....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adverse event; Polymorphisms of CYP2E1 and GST; Induced liver injury from treatment of tuberculosis; Hepatotoxicity; Pulmonary tuberculosis.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600381

Renal involvement in leprosy: retrospective analysis of 461 cases in Brazil
Provedor de dados: 55
Autores: Silva Júnior,Geraldo Bezerra da; Daher,Elizabeth De Francesco.
BACKGROUND: Renal lesions in leprosy have been extensively described, including amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis and granulomas. MATERIAL AND METHODS: A retrospective study was designed to detect renal function abnormalities in 461 leprosy patients, without any co-morbidity, seen in a university hospital in northeast Brazil. The laboratory test results concerning renal function were examined in the patients' medical records. RESULTS: The mean age was 39 ± 18 years and 217 (47%) were male. The mean duration of disease was 21 ± 38 months. Levels of creatinine above 1.4mg/dL had been detected in 40 patients (8.6%). The levels of creatinine and urea were higher in lepromatous leprosy patients. Proteinuria,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leprosy; Kidney; Renal abnormalities; Renal failure.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200007

Renal involvement in leptospirosis: new insights into pathophysiology and treatment
Provedor de dados: 55
Autores: Cerqueira,Thaís Bandeira; Athanazio,Daniel Abensur; Spichler,Anne Stambovsky; Seguro,Antônio Carlos.
Acute renal failure (ARF) is one of the most common complications of leptospirosis although the causal mechanisms are still unclear. Diverse mechanisms are implicated in leptospiral nephropathy and new data supports the role of peculiar ion transport defects. Besides antibiotic therapy, ARF management in leptospirosis requires dialytic therapy which is most efficient when started early. Dialysis is the standard supportive therapy even though recent evidence suggests clinical benefit from alternative treatments such as plasmapheresis and hemofiltration. Renal recovery is achieved soon after clinical improvement. The comprehension of the primary mechanisms of renal dysfunction will be helpful in the development of additional therapeutic tools for improving...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptospirosis; Kidney failure; Acute; Physiopathology; Dialysis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300016

Reply to “At the crossroads between early or delayed antiretroviral therapy initiation during TB/HIV coinfection"
Provedor de dados: 55
Autores: Saraceni,Valeria; Durovni,Betina; Pacheco,Antonio Guilherme; Chaisson,Richard E.; Golub,Jonathan E.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500578

Research nurse: new duties related to clinical trials. Experience of clinical research in oncovirology in Bahia/Brazil
Provedor de dados: 55
Autores: Bastos,Milena; Luz,Estela.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500023

Research on tuberculosis: 75 years of IBIT contributions
Provedor de dados: 55
Autores: Leite,Geraldo.
In 1937, the foundation year of the Brazilian Institute for Tuberculosis Research, three questions persisted in the researchers' mind: "What is the real value of BCG? How to solve the problem of the chest register of large communities? When will we have a specific drug for the treatment of tuberculosis?"; Along with this line of thought, the author presents a list of the Institute's main contributions, by pointing out the following topics: different diagnoses between pulmonary tuberculosis and pulmonary schistosomiasis; innocuity of iodine salts in pulmonary tuberculosis; relative value of Weltmann and Takata-Ara's reactions, and of blood and lipase rates in bacillosis; the value of the bacteriologic diagnosis (method of precipitation, standardization of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Research; Tuberculosis; Bahia; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200014

Resistance among Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Latin American countries: SMART 2013-2015
Provedor de dados: 55
Autores: Karlowsky,James A.; Hoban,Daryl J.; Hackel,Meredith A.; Lob,Sibylle H.; Sahm,Daniel F.
ABSTRACT Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. Gram-negative ESKAPE pathogens were collected from hospitalized patients in 11 Latin American countries from 2013 to 2015 as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) global surveillance program. In total, 2113 isolates from intra-abdominal infections (IAI) and 970 isolates from urinary tract infections (UTI) were tested against antimicrobial agents using standardized CLSI broth microdilution methodology. Of the agents tested, amikacin demonstrated the highest rates...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Surveillance; SMART; Imipenem; Ertapenem.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300343

Resistance of gram negative bacteria in hospital acquired pneumonia: a prospective study
Provedor de dados: 55
Autores: Dehghan,Farzaneh; Zolghadri,Nader; Boostani,Vahid; Shafii,Afsaneh; Eftekhaari,Tasnim Eghbal.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100113

Resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients
Provedor de dados: 55
Autores: Ahmad,Nafees; Javaid,Arshad; Sulaiman,Syed Azhar Syed; Ming,Long Chiau; Ahmad,Izaz; Khan,Amer Hayat.
Abstract  Background Fluoroquinolones are the backbone of multidrug resistant tuberculosis treatment regimens. Despite the high burden of multidrug resistant tuberculosis in the country, little is known about drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance among multidrug resistant tuberculosis patients from Pakistan.  Objective To evaluate drug resistance patterns, prevalence, and predictors of fluoroquinolones resistance in multidrug resistant tuberculosis patients.  Methods This was a cross-sectional study conducted at a programmatic management unit of drug resistant tuberculosis, Lady Reading Hospital Peshawar, Pakistan. Two hundred and forty-three newly diagnosed multidrug resistant tuberculosis patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fluoroquinolones; MDR-TB; Resistance; Private.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100041

Resistance to inhibitors of the human immunodeficiency virus type 1 integration
Provedor de dados: 55
Autores: Hazuda,Daria J.
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretrovirals; Integrase inhibitors; Raltegravir.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500016

Respiratory syncytial virus, infants and intensive therapy
Provedor de dados: 55
Autores: Bueno,Ieda Aparecida Correa; Riccetto,Adriana Gut Lopes; Morcillo,André Moreno; Arns,Clarice Weis; Baracat,Emílio Carlos Elias.
The aims of this study were to determine the presence of respiratory syncytial virus (RSV) and to assess the clinical features of the disease in infants with acute low respiratory tract infection hospitalized at pediatric intensive care units (PICU) of two university teaching hospitals in São Paulo State, Brazil. Nasopharyngeal secretions were tested for the RSV by the polymerase chain reaction. Positive and negative groups for the virus were compared in terms of evolution under intensive care (mechanical pulmonary ventilation, medications, invasive procedures, complications and case fatality). Statistical analysis was performed using the Mann Whitney and Fisher's exact tests. A total of 21 infants were assessed, 8 (38.1%) of whom were positive for RSV....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Respiratory syncytial virus; Infants; Intensive therapy; Genotypes.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100016

Respiratory syncytial virus rhinosinusitis in intensive care unit patients
Provedor de dados: 55
Autores: Silva,Alexandre Rodrigues da; Park,Marcelo; Boas,Lucy S. Vilas; Machado,Clarisse Martins.
This study reported a case of rhinosinusitis for Respiratory Syncytial Virus in Intensive Care Unit patient. The settings were Intensive Care Unit at Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil. One female HIV-infected patient with respiratory failure and circulatory shock due to splenic and renal abscesses, who developed rhinosinusitis caused by RSV and bacteria. Respiratory viruses can play a pathogenic role in airways infection allowing secondary bacterial overgrowth.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Respiratory Syncytial Virus; RSV; Rhinosinusitis; AIDS; ICU infection; Viral infection.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100034

Respiratory syncytial virus (RSV) in infants hospitalized for acute lower respiratory tract disease: incidence and associated risks
Provedor de dados: 55
Autores: Riccetto,Adriana Gut Lopes; Ribeiro,José Dirceu; Silva,Marcos Tadeu Nolasco da; Almeida,Renata Servan de; Arns,Clarice Weis; Baracat,Emílio Carlos Elias.
Respiratory syncytial virus (RSV) is one of the main causes of acute lower respiratory tract infections worldwide. We examined the incidence and associated risks for RSV infection in infants hospitalized in two university hospitals in the state of São Paulo. We made a prospective cohort study involving 152 infants hospitalized for acute lower respiratory tract infections (ALRTI) in two university hospitals in Campinas, São Paulo, Brazil, between April and September 2004. Clinical and epidemiological data were obtained at admission. RSV was detected by direct immunofluorescence of nasopharyngeal secretions. Factors associated with RSV infection were assessed by calculating the relative risk (RR). The incidence of RSV infection was 17.5%. Risk factors...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute respiratory infection; Respiratory syncytial virus; Risk factors.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500011

Respiratory viral coinfection among hospitalized patients with H1N1 2009 during the first pandemic wave in Brazil
Provedor de dados: 55
Autores: Camargo,Clarice; Guatura,Sandra Baltazar; Bellei,Nancy.
Influenza A coinfections with other respiratory viruses were investigated in 25.8% (41/159) of the samples from patients hospitalized in 2009 at our University Hospital. Out of the 41 influenza A cases, nine cases (21.9%) were coinfected with other viruses, with a similar frequency among children and adults (p = 0.47), and seasonal influenza cases were more prevalent than H1N1 2009 influenza virus. Adenovirus was the most frequently detected (4/9) among coinfected cases. Coinfection was not associated with higher morbidity or mortality (p = 0.75).
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Influenza A H1N1 2009; Influenza coinfection; Respiratory infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200013

Respiratory virus infections among hospitalized patients with suspected influenza A H1N1 2009 virus during the first pandemic wave in Brazil
Provedor de dados: 55
Autores: Watanabe,Aripuanã Sakurada Aranha; Carraro,Emerson; Moreira,Luciana; Camargo,Clarice; Sinohara,Juliana; Puerari,Diane; Guatura,Sandra; Granato,Celso; Bellei,Nancy.
INTRODUCTION: During the first pandemic wave of the influenza A H1N1 2009 virus, morbidity was particularly high in Brazil. Hospitalizations resulting from severe respiratory disease due to suspected influenza-like illness created an opportunity to identify other respiratory viruses causing lower respiratory infections. OBJECTIVE: The purpose of this study was to assess viral etiologies among samples collected during the first pandemic wave of H1N1 2009 from hospitalized patients with suspected cases in a Brazilian Sentinel Hospital. PATIENTS AND METHODS: Viral etiologies were investigated in samples from 98 children and 61 adults with fever, cough and dyspnea who were admitted to São Paulo Sentinel Hospital with suspected H1N1 infection. RESULTS: From...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza virus; Influenza A H1N1 2009 virus; Rhinovirus; Human metapneumovirus; Human respiratory syncytial virus; Respiratory viruses.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300007

Response of HIV-associated proteinuria to antiretroviral therapy in HIV-1-infected children
Provedor de dados: 55
Autores: Shah,Ira.
HIV-associated nephropathy has been found in children with HIV-1 infection as a late manifestation of this disease; it is associated with nephrotic syndrome with focal segmental glomerulosclerosis and/or mesangial hyperplasia with microcystic tubular dilatation. This is quite rare in children and no cases have been reported from India. Several mechanisms have been hypothesized for the HIV-induced renal damage. We report on two HIV-infected children with HIV-associated proteinuria and dramatic response to antiretroviral therapy.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV associated nephropathy; HIVAN; HIV associated proteinuria.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600011

Response predictors to treatment with pegylated interferon in chronic hepatitis B
Provedor de dados: 55
Autores: Ferreira,Paulo Roberto Abrão; Tenore,Simone de Barros.
The clinical and epidemiological importance of chronic B hepatitis is currently unquestionable as a cause of end-stage liver disease and hepatocellular carcinoma. Recently, predictors of treatment response of this disease have been studied, both before and during the course of medication. Therapy stopping rules have been proposed, which may be useful in patients presenting poor treatment tolerance. This review discusses the treatment response predictors usefulness, with emphasis on ALT, quantitative HBsAg and HBeAg, quantitative HBV-DNA and HBV genotype
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; HBsAg; HBeAg; HBV-DNA; Pegylated interferon.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500017

Response to the complete hepatitis B vaccine regimen in infants under 12 months of age: a case series
Provedor de dados: 55
Autores: Miralha,Alexandre Lopes; Malheiro,Adriana; Miranda,Angélica Espinosa; Rutherford,George Williams; Alecrim,Maria das Graças Costa.
OBJECTIVES: Describing rates of seroconversion and its associated factors in a series of Brazilian infants following the final dose of the vaccine at 6 months of age. METHODS: Peripheral blood samples were collected after the third dose of the vaccine for the detection of anti-hepatitis B surface antibodies among infants of 7-12 months of age. We measured the association between seroconversion and birthweight, gestational age, time since administration of the vaccine in the maternity hospital and whether or not testing for hepatitis B surface antigen had been performed during pregnancy. RESULTS: We examined 40 infants. The mean birthweight was 2787 g (standard deviation = 853 g) and mean gestational age was 37.5 (standard deviation = 3.08) weeks. The...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Newborn infant; Prematurity; Hepatitis B vaccine; Seroconversion.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100013

Response to treatment with interferon-alpha and ribavirin in patients with chronic Hepatitis C virus genotypes 2 and 3 depends on the degree of hepatic fibrosis
Provedor de dados: 55
Autores: Parise,Edison Roberto; Oliveira,Ana Cláudia de; Conceição,Raquel D. O.; Amaral,Ana Cristina; Leite,Katia.
The combined therapy with interferon alfa plus ribavirin (INF+RBV) is considered the most appropriate treatment for patients with chronic hepatitis C virus genotypes 2 and 3 in Brazil. However, wide variations in the rates of sustained viral response (SVR) have been reported among such patients. We evaluated, retrospectively, factors associated with SVR in subjects with chronic hepatitis C virus genotypes 2 and 3 and that received medication from the Health Secretariat of the state of São Paulo. One-hundred-seventy-seven consecutive patients with chronic hepatitis C were treated for 24 or 48 weeks according to the viral genotype. Patients co-infected with associated hepatic diseases or who had problems with alcohol abuse were excluded. The genotype of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon alpha; Ribavirin; Treatment of chronic C hepatitis; Genotype 2 and 3; Hepatic fibrosis.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200002

[RETRACTED ARTICLE] Antiviral and myocyte protective effects of IL-28A in coxsackievirus B3-induced myocarditis
Provedor de dados: 55
Autores: Wang,Shihong; Huang,Xingyuan; Zhang,Jing; Huang,Congxin.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200133

[RETRACTED ARTICLE] The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model
Provedor de dados: 55
Autores: Jie,Zhijun; Sun,Wei; Wang,Shanze; Koster,Frederick; Li,Bilan; Harrod,Kevin S.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400406

Retraction notice to "Antiviral and myocyte protective effects of IL-28A in coxsackievirus B3-induced myocarditis" [Braz. J. Infect. Dis. (2015) 132-140]
Provedor de dados: 55
Autores: Wang,Shihong; Huang,Xingyuan; Zhang,Jing; Huang,Congxin.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600678

Retraction notice to "The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model" [Braz. J. Infect. Dis. 18 (2014) 406-413]
Provedor de dados: 55
Autores: Jie,Zhijun; Sun,Wei; Wang,Shanze; Koster,Frederick; Li,Bilan; Harrod,Kevin S.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600677

Retreatment of hepatitis C patients who previously experienced treatment failure
Provedor de dados: 55
Autores: Gonçales Jr.,Fernando Lopes.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700016

Retrospective analysis of hepatitis B virus chronic infection in 247 patients: clinical stages, response to treatment and poor prognostic factors
Provedor de dados: 55
Autores: Cunha-Silva,Marlone; Marinho,Fábio R.T.; Oliveira,Paulo F.; Lopes,Tirzah M.; Sevá-Pereira,Tiago; Lorena,Sonia L.S.; Almeida,Jazon R.S.
Abstract  Background: Chronic hepatitis B is a major cause of cirrhosis, and the natural history of the disease has several clinical stages that should be thoroughly understood for the implementation of proper treatment. Nonetheless, curing the disease with antiviral treatment remains a challenge.  Aims: To describe the clinical course, response to treatment, and poor prognostic factors in 247 hepatitis B virus chronic infection patients treated in a tertiary hospital in Brazil.  Methods: This was a retrospective and observational study, by analyzing the medical records of HBV infected patients between January 2000 and January 2015.  Results: Most patients were male (67.2%) and 74.1% were HBeAg negative. Approximately 41% had cirrhosis and 8.5% were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Clinical stages; Treatment; Liver cirrhosis; Hepatocellular carcinoma.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400441

Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia
Provedor de dados: 55
Autores: Yanai,Mitsuru; Ogasawasa,Maiko; Hayashi,Yuta; Suzuki,Kiyozumi; Takahashi,Hiromichi; Satomura,Atsushi.
ABSTRACT  Objectives: Corynebacterium spp. are becoming recognized as pathogens that potentially cause various infections. We aimed to evaluate the clinical characteristics associated with Corynebacterium spp. bacteremia.  Patients and methods: We retrospectively reviewed the medical records of all adult patients who had positive blood cultures for Corynebacterium spp. in a single university hospital between January 2014 and December 2016. Patients were divided into a bacteremia group and a contamination group based on microbiological test results and clinical characteristics. Patients’ characteristics, antimicrobial susceptibility of isolated species, antimicrobials administered, and patient outcomes were evaluated.  Results: Corynebacterium spp. were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Corynebacterium species; Blood culture; Bloodstream infection; Contamination.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100024

Retrospective study of 668 cultures for mycobacteria in a reference hospital for AIDS in Southern Brazil
Provedor de dados: 55
Autores: Pasqualotto,Alessandro Comarú; Rosa,Daniela Dornelles; Pereira,Maria do Carmo Fontoura; Targa-Ferreira,Roberto L.; Santos,Breno Riegel.
Although AIDS patients in other countries are frequently diagnosed as having atypical mycobacterial infection, in Southern Brazil there is a clinical impression that Mycobacterium tuberculosis is the rule rather than the exception. We made a retrospective review of cultures for mycobacteria at our hospital in order to determine the frequency of atypical mycobacteria and Mycobacterium tuberculosis in hospitalised patients in Porto Alegre, Brazil. Mycobacterium tuberculosis was the most frequent isolate (79.9%), regardless of HIV serostatus. Only 1.5% of the cultures yielded atypical mycobacteria, all of which in AIDS patients. Mycobacterium tuberculosis was diagnosed in most of the HIV-infected patients (81.2%). We conclude that Mycobacterium tuberculosis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; AIDS; Southern Brazil.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200005

Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load
Provedor de dados: 55
Autores: Rathsam-Pinheiro,Regina Helena; Boa-Sorte,Ney; Grassi,Maria Fernanda Rios; Copello,Úrsula Cury; Rios,Karla Tayrine Silva Guimarães; Araújo,Thessika; Galvão-Castro,Bernardo.
ABSTRACT  Background: The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described.  Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohort of HTLV-1-infected individuals living in Salvador, Brazil.  Methods: A cross-sectional study was conducted between June 2004 and September 2017 at the Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from 758 HTLV-1-infected patients was collected. A complete ophthalmologic examination was performed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengal and Schirmer I Tests. KCS...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; Keratoconjunctivitis sicca; Prevalence; Dry eye syndromes.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200095

Revisiting the Rich's formula: an update about granulomas in human tuberculosis
Provedor de dados: 55
Autores: Coelho Filho,João Carlos; Takenami,Iukary; Arruda,Sérgio.
The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rich's formula; Tuberculosis; Immunopathogenesis; Granuloma; Hypersensitivity.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200017

Rhabdomyolysis following fish consumption: a contained outbreak of Haff Disease in São Paulo
Provedor de dados: 55
Autores: Almeida,Lyna K.R.; Gushken,Fernanda; Abregu-Diaz,Dario R.; Muniz Jr.,Roberto; Degani-Costa,Luiza H.
Tipo: Info:eu-repo/semantics/other
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400278

Rhinoscleroma causing severe bilateral nasal obstruction
Provedor de dados: 55
Autores: Moraes,Mário Augusto Pinto de; Magalhães,Albino Verçosa de; Marinho,Larissa Cardoso; Azevedo,Ana Emília Borges de; Carneiro,Fabiana Pirani; Raymundo,Igor Teixeira.
Rhinoscleroma is a chronic, infectious and granulomatous disease of the respiratory tract. There is often a delay in diagnosis due to unfamiliarity with the disease and also because culture is not always positive. We report a case in a 26-year-old woman with granular mass obstructing bilateral nasal cavities and causing breathing difficulty. Histopathological examination showed characteristic Mikulicz histiocytes containing numerous Gram-negative intracellular rod-shaped bacilli consistent with the diagnosis of rhinoscleroma. The patient was treated with gemifloxacin and tetracycline and remains asymptomatic over a year follow-up period. It is important to consider rhinoscleroma in cases of chronic nasal obstruction. As culture is not always positive,...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Rhinoscleroma; Nasal obstruction; Histopathology.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200015

Ribavirin use in pediatric patients with Crimean Congo Hemorrhagic Fever: is it really necessary?
Provedor de dados: 55
Autores: Tezer,Hasan; Ozkaya-Parlakay,Aslinur; Gulhan,Belgin; Kanik-Yuksek,Saliha.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200222

Ribotyping, biotyping and capsular typing of Haemophilus influenzae strains isolated from patients in Campinas, southeast Brazil
Provedor de dados: 55
Autores: Lancellotti,Marcelo; Pace,Fernanda de; Stehling,Eliana Guedes; Villares,Maria Cecília Barisson; Brocchi,Marcelo; Silveira,Wanderley Dias da.
Forty-five Haemophilus influenzae strains isolated from patients were characterized based on biochemical characteristics. Their capsular types were determined by polymerase chain reaction (PCR); they were compared, using two molecular methods [ribotyping with a specific DNA probe amplified from the 16S rDNA region from H. influenzae and through restriction fragment length polymorphism (RLFP) of an amplified 16S DNA region]. The strains were better discriminated by the ribotyping technique that used the 16S probe and by the combination of both techniques. Biotypes I and IV were the most common, followed by biotypes VI, VIII and III. Biotypes II and VII were not found. Most of the capsular samples were nontypable (89%), with capsular types a and b found in 2...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haemophilus influenzae; Characterization; Ribotyping; Serotype; Biotype.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500015

Rifampin induced angioedema: a rare but serious side effect
Provedor de dados: 55
Autores: Mirsaeidi,Mehdi; Schraufnagel,Dean.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100102

Risk behavior score: a practical approach for assessing risk among men who have sex with men in Brazil
Provedor de dados: 55
Autores: Rocha,Gustavo Machado; Kerr,Lígia Regina Franco Sansigolo; Kendall,Carl; Guimarães,Mark Drew Crosland.
ABSTRACT HIV/AIDS epidemic is not well controlled, and multiple sexual behavior factors help explain high rates of HIV infection among men who have sex with men (MSM). This article proposes to exam the use of a potential risk behavior score for HIV infection, based on the type and number of sexual partners, and condom use, and their associated factors in a sample of MSM in Brazil. A cross sectional RDS (Respondent Driven Sampling) study was performed among 3738 MSM aged 18+ years old from ten Brazilian cities. The risk behavior score was composed by the number of male partners and anal condom use in the last year with steady, casual, and commercial partners. Most participants were 25+ years old (58.1%), non-white (83.1%), and single (84.9%). Final weighted...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Homosexuals; High-risk sex; Unsafe sex; HIV; AIDS.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200113

Risk factors and evolution of Ventilator-associated pneumonia by Staphylococcus aureus sensitive or resistant to oxacillin in patients at the intensive care unit of a Brazilian University Hospital
Provedor de dados: 55
Autores: Moreira,Michel R.; Cardoso,Renata L.; Almeida,Alair B.; Gontijo Filho,Paulo P.
This study investigated the participation and risk factors of VAP by resistant (ORSA) or sensitive (OSSA) S. aureus to oxacillin and evaluated the implications of adequate or inadequate empirical antimicrobial therapeutics in its evolution in patients interned in a mixing ICU of adults. A patient control-case study with PAVs by ORSA and OSSA was carried out from May 2005 to April 2007 involving 993 patients. VAP was defined based on clinical, radiological, and microbiological (&gt; 106 CFU/mL count in the tracheal aspirate) criteria. Four hundred and seventy four (47.7%) patients were submitted to mechanical ventilation with 141 (29.7%) VAPs, with S. aureus as the most frequent agent (41.2%). The phenotype ORSA accounted for 47.5% and OSSA for 52.5%,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator-associated pneumonia; Hospital infection; Staphylococcus aureus; Resistant microorganisms.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600011

Risk factors for bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
Provedor de dados: 55
Autores: Quirante,Olivia Ferrández; Cerrato,Santiago Grau; Pardos,Sonia Luque.
The objective of this study was to identify risk factors for bacteremia by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae. Retrospective case-control study performed in a 450-bed acute care academic tertiary hospital in Barcelona, Spain. Cases included 53 patients with ESBL-producing E. coli or K. pneumoniae bacteremia, and 159 controls with non-ESBL-producing E. coli or K. pneumoniae bacteremia. Controls were matched in a 3:1 ratio to case patients according to species of infecting organism, age, and severity of illness in the 24-48h before blood sample collection for culture calculated by the Simplified Acute Physiology Score (SAPS II) system. Previous antimicrobials were more frequently administered to cases...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bacteremia; Β-lactamases; Risk factors.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400012

Risk factors for catheter-related bloodstream infection: a prospective multicenter study in Brazilian intensive care units
Provedor de dados: 55
Autores: Bicudo,Daniela; Batista,Ruth; Furtado,Guilherme Henrique; Sola,Angela; Medeiros,Eduardo Alexandrino Servolo de.
INTRODUCTION: Central venous catheters (CVC) are devices of great importance in health care. The advantages gained from the use of catheters outweigh the complications that might result from their use, among which bloodstream infections (BSI). In spite of its importance, few national studies have addressed this issue. OBJECTIVE: The aim this study was to determine the incidence of BSI in patients with CVC, hospitalized in ICU, as well as the variables associated with this complication. METHODS: Multicentric cohort study carried out at ICUs of three hospitals at Universidade Federal de São Paulo complex. RESULTS: A total of 118 cases of BSI in 11.546 catheters day were observed: 10.22 BSI per 1,000 catheters day. On average, BSI was associated to seven...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intensive care units catheter-related infections catheterization; BSI.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400005

Risk factors for Hospital-Acquired Pneumonia in nonventilated adults
Provedor de dados: 55
Autores: Fortaleza,Carlos Magno Castelo Branco; Abati,Paulo Afonso Martins; Batista,Márcia Regina; Dias,Adriano.
Although most recent publications focus on Ventilator-associated Pneumonia, Non-Ventilator-associated Hospital-acquired pneumonia (NVHAP) is still worrisome. We studied risk factors for NVHAP among patients admitted to a small teaching hospital. Sixty-six NVHAP case patients and 66 controls admitted to the hospital from November 2005 through November 2006 were enrolled in a case-control study. Variables under investigation included: demographic characteristics, comorbidities, procedures, invasive devices and use of medications (Sedatives, Antacids, Steroids and Antimicrobials). Univariate and multivariable analysis (hierarchical models of logistic regression) were performed. The incidence of NVHAP in our hospital was 0.68% (1.02 per 1,000 patients-day)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hospital acquired pneumonia; Non-ventilator associated pneumonia; Risk factors.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400009

Risk factors for infection after cardiovascular surgery in children in Argentina
Provedor de dados: 55
Autores: Rosanova,Maria Teresa; Allaria,Adrian; Santillan,Alejandro; Hernandez,Claudia; Landry,Luis; Ceminara,Rodolfo; Berberian,Griselda.
Infections after cardiovascular surgery are an important cause of morbidity and mortality. This paper described the study of risk factors associated with development of infections. This is a prospective study, setting in a Hospital JP Garrahan, a tertiary and referral center of Buenos Aires, Argentina. All patients with cardiac surgeries between 1/11/01 to 1/1/ 2002 were included. The median age of p was 30 months (r: 1-212 m), 184 p (53%) were boys, 21% (75) had underlying disease, being the genetic disorders or undernutrition the most frequent, 56 p (16%) had previous surgery, 36 p (10%) had received previous antibiotics and 30 (9%) of them had previous infection, An ASA score higher than or equal to 3 was found in 308 p (88%). Median hospital stay...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infections; Cardiovascular surgery; Children.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600005

Risk factors for infection by extended-spectrum beta-lactamase producing Klebsiella pneumoniae in a tertiary hospital in Salvador, Brazil
Provedor de dados: 55
Autores: Silva,Nanci; Oliveira,Márcio; Bandeira,Antonio Carlos; Brites,Carlos.
Nosocomial infection caused by extended-spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-Kp) have been frequently reported worldwide. We have no information on such problems in Bahia, Brazil. OBJECTIVES: Evaluate the risk factors for nosocomial infections caused by ESBL-Kp, in a tertiary hospital, in Bahia, Brazil. MATERIAL AND METHODS: We evaluated all reported cases of nosocomial infections caused by ESBL-Kp in a private, tertiary hospital, in Salvador, Brazil, from 2000 through 2004. We compared patients with a diagnosis of ESBL-Kp (cases) and patients infected by non-ESBL producing K. pneumoniae (controls). Mean age, underlying disease, and frequency of invasive procedures were compared between the two groups. History of previous use of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infections; ESBL; Klebsiella pneumoniae; Bacterial resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300007

Risk factors for KPC-producing Klebsiella pneumoniae bacteremia
Provedor de dados: 55
Autores: Tuon,Felipe F.; Rocha,Jaime L.; Toledo,Paula; Arend,Lavinia N.; Dias,Camila H.; Leite,Talita M.; Penteado-Filho,Sergio R.; Pilonetto,Marcelo; Zavascki,Alexandre P.
The molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae (KPC) has been largely investigated, but limited clinical information is available. A case-control study was performed to evaluate the risk factors for KPC bacteremia in hospitalized patients. Cases were patients with KPC bacteremia and controls were patients with non-KPC bacteremia. A total of 85 patients were included, 18 (21.2%) were KPC, and 67 (78.8%) were non-KPC (40 [59.7%] of them were extended-spectrum beta-lactamase producers). All KPC isolates were type 2 producers. These isolates belong to five distinct clones. Multivariate analysis showed that age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02 - 1.11; p = 0.004), presence of mechanical ventilation (OR,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Klebsiella pneumoniae; Bacteremia risk factors; Klebsiella pneumoniae; Carbapenemases; Carbapenems.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500002

Risk factors for laboratory-confirmed bloodstream infection in neonates undergoing surgical procedures
Provedor de dados: 55
Autores: Romanelli,Roberta Maia de Castro; Anchieta,Lêni Márcia; Carvalho,Elaine Alvarenga de Almeida; Silva,Lorena Ferreira da Glória e; Nunes,Rafael Viana Pessoa; Mourão,Paulo Henrique; Clemente,Wanessa Trindade; Bouzada,Maria Cândida Ferrarez.
BACKGROUND: Healthcare Associated Infections constitute an important problem in Neonatal Units and invasive devices are frequently involved. However, studies on risk factors of newborns who undergo surgical procedures are scarce. OBJECTIVE: To identify risk factors for laboratory-confirmed bloodstream infection in neonates undergoing surgical procedures. METHODS: This case-control study was conducted from January 2008 to May 2011, in a referral center. Cases were of 21 newborns who underwent surgery and presented the first episode of laboratory-confirmed bloodstream infection. Control was 42 newborns who underwent surgical procedures without notification of laboratory-confirmed bloodstream infection in the study period. Information was obtained from the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Newborn intensive care units; Infection control; Surgery; Sepsis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400400

Risk factors for mortality in Acinetobacter bacteremia
Provedor de dados: 55
Autores: Yang,Seongeun; Yoon,Hee Jung; Ki,Mo Ran.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500018

Risk factors for mortality in burn children
Provedor de dados: 55
Autores: Rosanova,Maria Teresa; Stamboulian,Daniel; Lede,Roberto.
Studies about risk factors for mortality in burn children are scarce. We conducted this study to evaluate the risk factors for mortality in pediatric burn patients. We included 110 patients. Mean age was 31.5 months (range: 1 to 204). The burn surface was between 1% and 95%(median 27%) Type of burn was: A or superfitial in 39 patients (36%), AB or intermediate in 19 (17%), and B or full thickness in 52 (47%). Inhalatory injury was present in 52 patients (47%). Invasive procedures were: venous catheter, 90 patients (82%), arterial catheter, 83patients (75.5%), urinary catheter, 86 patients (78%), and mechanical ventilation, 75 patients (68%). In 84 patients, 128 infections were diagnosed. in 53 cases (48%). Multiresistant Pseudomonas aeruginosa and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Burns; Mortality; Children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200144

Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae
Provedor de dados: 55
Autores: Tuon,Felipe F.; Graf,Maria Esther; Merlini,Alexandre; Rocha,Jaime L.; Stallbaum,Suellen; Arend,Lavinia N.; Pecoit-Filho,Roberto.
Abstract  Background: The ideal therapeutic option for ventilator associated pneumonia caused by carbapenem-resistant Enterobacteriaceae is not defined. The aim of this study was to assess mortality-associated risk factors in patients with VAP by CRE and determine the outcome of several treatment options.  Methods: This was a retrospective study performed in two tertiary hospitals involving patients with VAP caused by CRE between January 2010 and August 2014. The outcomes were mortality within 30 days of VAP diagnosis and overall mortality during hospital admission. Risk factors for mortality were assessed by comparing variables of survivors and non-survivors.  Results: One hundred and twelve patients with CRE-VAP were included, 73 (65%) male, median age...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenemase-producing Klebsiella pneumoniae; Ventilator-associated pneumonia; Risk factors; Mortality; Treatment.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100001

Risk factors for nosocomial bloodstream infection caused by multidrug resistant gram-negative bacilli in pediatrics
Provedor de dados: 55
Autores: Arnoni,Mariana V.; Berezin,Eitan N.; Martino,Marinês D.V.
The aim of this study was to identify the risk factors for nosocomial bloodstream infections by multidrug resistant Gram-negative bacilli. From November 2001 to December 2003, in the Pediatric Department of the Santa Casa de São Paulo, a retrospective case-control study was developed concerning patients who had nosocomial bloodstream infection caused by Gram-negative bacilli. Patients with multidrug resistant infections were designated as case patients, and control patients were those with an infection that did not meet the criteria for multidrug resistance. Previous use of central venous catheter and previous use of vancomycin plus third generation cephalosporins were associated to a higher chance of infections by multidrug resistant Gram-negative bacilli...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bloodstream infection; Gram-negative bacilli; Risk factors.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200020

Risk factors for nosocomial infection in a Brazilian neonatal intensive care unit
Provedor de dados: 55
Autores: Távora,Ana Carolina Vieira Costa Fernandes; Castro,Antonieta B.; Militão,Maria Afonsina M.; Girão,José Eduilton; Ribeiro,Karina de Cássia Braga; Távora,Lara Gurgel Fernandes.
This study was designed to describe the epidemiology and risk factors for nosocomial infection (NI) in a Brazilian neonatal intensive care unit (NICU). This study was a retrospective cohort from January to December, 2003. All neonates admitted to the NICU. Infection surveillance was conducted according to the NNIS, CDC. Chi-square test and logistic regression model were performed for statistical analyses. The study was conducted at a public, tertiary referral NICU of a teaching hospital in the Northeast of Brazil. A total of 948 medical records were reviewed. Overall NI incidence rate was 34%. The main neonatal NI was bloodstream infection (68.1%), with clinical sepsis accounting for 47.2%, and pneumonia was the second most common NI (8.6%). Multivariate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risk factors; Neonatal nosocomial infection; Neonatal intensive care unit.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100016

Risk factors for nosocomial infection in trauma patients
Provedor de dados: 55
Autores: Giamberardino,Heloisa Ihle Garcia; Cesário,Eliane Pereira; Carmes,Eliane Ribeiro; Mulinari,Rogério Andrade.
Several factors are implicated in the increased vulnerability of multiple trauma victims to infection, especially in intensive care-units (ICU). This cohort study was designed to report the incidence, the topography, the etiology and to identify the risk factors for infection in trauma patients admitted in an ICU. From January 2000 to December 2001, 416 trauma patients were admitted to the ICU for more than 24 hours, the mean length of stay was 9.3 days (range 2-65) and 188 (45%) patients developed a total of 290 NI. The most prevailing infections were pneumonia (49%), bloodstream (19%) and urinary tract infections (12%). The variables studied were: the demographic data, diagnosis on admission, site and mechanism of injury, type and number of surgeries,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trauma; Nosocomial infection; Intensive care.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200024

Risk factors for pan-resistant Pseudomonas aeruginosa bacteremia and the adequacy of antibiotic therapy
Provedor de dados: 55
Autores: Tuon,Felipe F.; Gortz,Lucas W.; Rocha,Jaime L.
INTRODUCTION: The aim of this study was to determine risk factors for acquiring carbapenemresistant Pseudomonas aeruginosa bacteremia (CR-PA) and factors associated with in-hospital mortality. METHODS: Seventy-seven cases of bacteremia caused by P. aeruginosa were evaluated in a hospital with high incidence of CR-PA. Clinical and laboratorial factors, and previous use of antibiotics were also evaluated. In one analysis, CR-PA and carbapenem-susceptible P. aeruginosa (CS-PA) bacteremia were compared. A second analysis compared patients who died with survivors. RESULTS: Among 77 P. aeruginosa bacteremia, 29 were caused by CR-PA. Admission to the intensive care unit, higher number of total leukocytes, and previous use of carbapenem were statistically...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Imipenem; Meropenem; Antibiotic resistance; Risk factor.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400007

Risk factors for poor immune response to influenza vaccination in elderly people
Provedor de dados: 55
Autores: Bellei,N.C.J.; Carraro,E.; Castelo,A.; Granato,C.F.H.
Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. Some studies have pointed out low immunogenicity in this group. Health status has been poorly investigated as a risk factor that may influence the immune response to influenza vaccine. We established an immunization response study of a highly-matched elderly population in a nursing home. One-hundred-twenty subjects of Ashkenazian origin had their vaccine-induced antibody response assessed. Good response was obtained in 30.8% (37/120), and 31.7% (38/120) did not react. A lack of good response was found to be associated with dementia (P=0.016) in a multivariate analysis. In addition to dementia, malnutrition was frequently observed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza; Vaccination; Immune response; Risk factors; Dementia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400011

Risk factors for surgical site infection following cesarean section in a Brazilian Women's Hospital: a case-control study
Provedor de dados: 55
Autores: Farret,Túlio Cícero Franco; Dallé,Jessica; Monteiro,Vinícius da Silva; Riche,Cezar Vinícius Würdig; Antonello,Vicente Sperb.
The present study evaluated patients with diagnosis of surgical site infection (SSI) following cesarean section and their controls to determinate risk factors and impact of antibiotic prophylaxis on this condition.  Methods: All cesareans performed from January 2009 to December 2012 were evaluated for SSI, based on criteria established by CDC/NHSN. Control patients were determined after inclusion of case patients. Medical records of case and control patients were reviewed and compared regarding sociodemographic and clinical characteristics.  Results: Our study demonstrated an association following univariate analysis between post-cesarean SSI and number of internal vaginal examinations, time of membrane rupture, emergency cesarean and improper use of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Surgical site infection; Cesarean section; Postpartum complications.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200113

Risk factors for Toxoplasma gondii infection in women of childbearing age
Provedor de dados: 55
Autores: Avelino,Mariza Martins; Campos Júnior,Dioclécio; Parada,Josetti Barbosa de; Castro,Ana Maria de.
OBJECTIVES: Determine the risk factors involved in toxoplasmosis transmission and determine whether pregnancy is a risk factor for toxoplasmosis infection. STUDY DESIGN: Cross-sectional study carried out on 2,242 women at childbearing age. An indirect immunofluorescence reaction was used to identify immunity to Toxoplasma gondii. Previous gestations were also analyzed as a possible risk factor. The results were analyzed by chi2 and OR tests, and by variance analysis. The sample was statistically balanced according to social-economic risk factors. RESULTS: Previously pregnant women were 1.74 times more frequently infected with toxoplasmosis, regardless of environmental conditions. Pregnant women living under unfavorable environmental conditions had an...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis in pregnancy; Risk factor; Host animals; Means of transmission; Contaminant elements.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200007

Risk factors of oropharyngeal carriage of Pseudomonas aeruginosa among patients from a Medical-Surgical Intensive Care Unit
Provedor de dados: 55
Autores: Fortaleza,Carlos Magno Castelo Branco; Figueiredo,Lígia Castellon; Beraldo,Carolina Contador; Melo,Edson Carvalho de; Póla,Patrícia Maria Sales; Aragão,Valéria Drummond Nagem.
Oropharyngeal carriage of Pseudomonas aeruginosa is associated with increased risk of infection and may provide a source for spread of drug-resistant strains. In order to assess the incidence and risk factors of oropharyngeal carriage, we conducted a retrospective cohort study based on results of surveillance cultures (oropharyngeal swabs) from a medical-surgical intensive care unit, collected from March 2005 through May 2006. Variables investigated included demographic characteristics, comorbid conditions, invasive procedures, use of devices and use of antimicrobials. Thirty case patients with P. aeruginosa carriage were identified. Other 84 patients with surveillance cultures negative to P. aeruginosa were enrolled as control subjects. Case patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Colonization; Oropharyngeal carriage; Surveillance cultures; Intensive care unit.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300004

Risk factors of renal scars in children with acute pyelonephritis
Provedor de dados: 55
Autores: Ehsanipour,Fahimeh; Gharouni,Minoo; Rafati,Ali Hoseinpoor; Ardalan,Maryam; Bodaghi,Neda; Otoukesh,Hasan.
OBJECTIVE: The aim of this study was to determine the association between previously documented risk factors such as recurrent pyelonephritis with the incidence of renal scarring after acute pyelonephritis in children. MATERIAL AND METHODS: Children with acute pyelonephritis who were admitted to the Department of Pediatrics of a teaching hospital during 2007-2009 were enrolled in this study. DMSA scans were obtained 4-6 months after the last episode of pyelonephritis in all patients. RESULTS: A total of 80 children with acute pyelonephritis were enrolled in this study. Most of them were girls (77.5%), with a median age of 12 months. Nearly half of the children (n = 44; 55%) had one or more renal scars. The distribution of gender, CRP level and leukocytosis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Health of institutionalized children; Pyelonephritis; Vesicoureteral reflux.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100003

Risk factors related to hypertension among patients in a cohort living with HIV/AIDS
Provedor de dados: 55
Autores: Arruda Junior,Evanizio Roque de; Lacerda,Heloisa Ramos; Moura,Libia Cristina Rocha Vilela; Albuquerque,Maria de Fatima Pessoa Militão de; Miranda Filho,Democrito de Barros; Diniz,George Tadeu Nunes; Albuquerque,Valeria Maria Gonçalves de; Amaral,Josefina Cláudia Zirpoli; Ximenes,Ricardo Alencar de Arraes; Monteiro,Verônica Soares.
INTRODUCTION: Studies disagree as to whether there is a greater prevalence of hypertension among HIV/AIDS patients and the role of antiretroviral therapy. OBJECTIVE: Evaluate the prevalence of hypertension and risk factors in a cohort of HIV-infected patients, with emphasis on antiretroviral therapy. METHOD: Case-control study conducted at baseline of a cohort, between June/2007 and December/2008 in Pernambuco/Brazil. Blood pressure was classified as normal, prehypertension, and hypertension. RESULTS: Of 958 patients, 245 (25.6%) had hypertension (cases), 325 (33.9%) had prehypertension, and 388 (40.5%) were normotensive (controls). Comparison between hypertensive and normotensive patients showed that traditional factors, such as age &gt; 40 (OR = 3.06, CI...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/AIDS; Hypertension; Antiretroviral therapy; Cardiovascular risk.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300014

Risk of coronary artery disease in individuals infected with human immunodeficiency virus
Provedor de dados: 55
Autores: Vilela,Felippe Dantas; Lorenzo,Andrea Rocha de; Tura,Bernardo Rangel; Ferraiuoli,Giovanna Ianini; Hadlich,Marcelo; Barros,Marcelo Viana de Lima; Lima,Ana Beatriz Ribeiro; Meirelles,Vanderson.
Current treatment for human immunodeficiency virus (HIV) infection has improved survival and allowed infected patients to develop atherosclerotic coronary artery disease (CAD). Specific strategies to reduce cardiovascular risk in the infected population have not been developed. It is necessary to know the magnitude of cardiovascular risk in this population. OBJECTIVES: This study aimed to assess cardiovascular risk using a well-known clinical score and to investigate coronary artery calcium scoring (CACS) in this population. METHODS: This was a cross-sectional study. Adults with HIV infection were studied. Demographic, clinical and anthropometric data, serum glucose and lipids were obtained. Cardiovascular risk was calculated through Framingham risk score...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coronary artery disease; HIV; Cardiovascular diseases; HIV protease inhibitors.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600004

Risk of tuberculosis among household contacts in Salvador, Bahia
Provedor de dados: 55
Autores: Lemos,Antonio Carlos; Matos,Eliana D; Pedral-Sampaio,Diana B; Netto,Eduardo M.
Tuberculosis is one of the most important infectious diseases in the world. Only 68% of the estimated new tuberculosis (TB) cases in Brazil are diagnosed. Our aim was to determine the risk of infection among household contacts. Study design. Cohort of tuberculin-negative household contacts followed for 12 Months. Methods. Household contacts of randomly selected index acid-fast bacilli (AFB)-positive TB cases were evaluated through clinical examination, thorax X-ray, tuberculin, AFB smear and culture. Contacts with a negative response to the tuberculin test (less than 10 mm diameter) were retested after 90 days. Tuberculin reversal (used as a parameter of infection risk) was defined as an increase of at least 10 mm from the last measurement. Results. 269...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Infection; Epidemiology; Prevalence.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600006

Risk of vancomycin-resistant enterococci bloodstream infection among patients colonized with vancomycin-resistant enterococci
Provedor de dados: 55
Autores: Kara,Ahu; Devrim,İlker; Bayram,Nuri; Katipoğlu,Nagehan; Kıran,Ezgi; Oruç,Yeliz; Demiray,Nevbahar; Apab,Hurşit; Gülﬁdan,Gamze.
Background:Vancomycin-resistant enterococci colonization has been reported to increase the risk of developing infections, including bloodstream infections.Aim:In this study, we aimed to share our experience with the vancomycin-resistant enterococci bloodstream infections following gastrointestinal vancomycin-resistant enterococci colonization in pediatric population during a period of 18 months.Method:A retrospective cohort of children admitted to a 400-bed tertiary teaching hospital in Izmir, Turkey whose vancomycin-resistant enterococci colonization was newly detected during routine surveillances for gastrointestinal vancomycin-resistant enterococci colonization during the period of January 2009 and December 2012 were included in this study. All...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bloodstream infections; Colonization; Immunosupression; Vancomycin-resistant enterococcus.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100058

Risk-based assessment does not distinguish between recent and chronic HIV-1 infection in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Merçon,Monica; Tuboi,Suely H.; Batista,Sônia Maria; Telles,Sandra Regina Barros; Grangeiro,José Roberto; Zajdenverg,Roberto; Lago,Regina Ferro do; Barroso,Paulo Feijó; Melo,Maria de Fátima; Schechter,Mauro.
This study investigated the risk factors associated with recent and chronic HIV infections among individual attending a voluntary counseling and testing (VCT) site in Rio de Janeiro, Brazil. In a cross-sectional study, recent HIV infections were detected by the sensitive/less-sensitive test, using Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS) strategy, and compared to chronic HIV infection and HIV negative individuals. Seroincidence was estimated and risk factors associated with recent and chronic infections were assessed using multinomial logistic regression. Among the 7,379 individuals tested between June 2006 and April 2007, the overall prevalence and incidence of HIV infection were 7.5%; and 1.39/100 PY, respectively. In...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: STARHS; HIV seroconversion; VCT Steady partner HIV HIV prevention.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400006

RNA interference inhibits herpes simplex virus type 1 isolated from saliva samples and mucocutaneous lesions
Provedor de dados: 55
Autores: Silva,Amanda Perse da; Lopes,Juliana Freitas; Paula,Vanessa Salete de.
The aim of this study was to evaluate the use of RNA interference to inhibit herpes simplex virus type-1 replication in vitro. For herpes simplex virus type-1 gene silencing, three different small interfering RNAs (siRNAs) targeting the herpes simplex virus type-1 UL39 gene (sequence si-UL 39-1, si-UL 39-2, and si-UL 39-3) were used, which encode the large subunit of ribonucleotide reductase, an essential enzyme for DNA synthesis. Herpes simplex virus type-1 was isolated from saliva samples and mucocutaneous lesions from infected patients. All mucocutaneous lesions' samples were positive for herpes simplex virus type-1 by real-time PCR and by virus isolation; all herpes simplex virus type-1 from saliva samples were positive by real-time PCR and 50% were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Herpes simplex virus type 1; Real-time PCR; SiRNA.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400441

Rocky Mountain spotted fever: brain imaging findings
Provedor de dados: 55
Autores: Loureiro,Bruna Melo Coelho; Reis,Fabiano; Pereira,Grazielly de Fátima; Lalli,Cristina Alba.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200153

Role of antibodies reactive to HspX in discriminating pulmonary tuberculosis contacts with high risk of developing active disease
Provedor de dados: 55
Autores: Reis,Michelle Cristina Guerreiro dos; Silva,Bruna Daniella de Souza; Sousa,Eduardo Martins de; Junqueira-Kipnis,Ana Paula.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600022

Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B
Provedor de dados: 55
Autores: Li,Feng; Zhu,Chang-Lai; Zhang,Hong; Huang,Hua; Wei,Qun; Zhu,Xiang; Cheng,Xiao-Yang.
OBJECTIVES: The aim of this study was to evaluate the diagnostic performance of serum HA and LN as serum markers for predicting significant fibrosis in CHB patients. METHODS: Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined according to the Metavir scoring-system. The diagnostic performances of all indexes were evaluated by the receiver operating characteristic (ROC) curves. RESULTS: Serum HA and LN concentrations increased significantly with the stage of hepatic fibrosis, which showed positive correlation with the stages of liver fibrosis (HA: r = 0.875, p &lt; 0.001; LN: r = 0.610, p &lt; 0.001). There were significant differences of serum HA and LN levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Chronic Hyaluronic acid Laminin Liver Cirrhosis ROC curve.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100002

Role of laboratory in rapid diagnosis of atypical mumps
Provedor de dados: 55
Autores: Vandana,KE; Arunkumar,G; Bairy,Indira.
Fairly large number of mumps virus infections present atypically without parotitis leading to delay in diagnosis and increased morbidity. Awareness of such presentations and inclusion of serological test for detecting IgM-specific antibodies could help in solving diagnostic dilemma, especially in unvaccinated individuals from developing countries.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mumps; Atypical presentations; IgM; Indirect immunofluorescence assay.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200018

Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population
Provedor de dados: 55
Autores: Rani,Asima; Nawaz,Syed Kashif; Irfan,Shazia; Arshad,Muhammad; Bashir,Razia; Shaheen,Najma.
Abstract  Introduction: The present study was designed to investigate the association between rs8177374 polymorphism and malaria symptoms due to exposure of Plasmodium vivax and Plasmodium falciparum.  Materials and methods: A total of 454 samples were included in the study (228 malaria patients and 226 healthy individuals). Malaria patients, divided into P. vivax and P. falciparum groups on the basis of the causative species of Plasmodium, were categorized into mild and severe on the basis of clinical outcomes according to WHO criteria. Healthy individuals were used as controls. Allele specific PCR based strategy was used for the identification of rs8177374 SNP.  Results: MyD88-adaptor-like gene polymorphism was associated with susceptibility to malaria...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium; Rs8177374; MAL; Pakistani population.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400418

Role of the Parasight-F test in the diagnosis of complicated Plasmodium falciparum malarial infection
Provedor de dados: 55
Autores: Arora,Sandeep; Gaiha,Manorama; Arora,Anju.
An evaluation was made of the diagnostic efficacy and utility of the Parasight-F test in diagnosing Plasmodium falciparum malaria, compared with conventional microscopy, particularly in severe and complicated cases. This study was designed as a prospective, case control hospital-based study. Febrile patients suspected to be suffering from malaria were selected randomly and were subjected to peripheral smear examinations (thick and thin) and Parasight-F tests till the required number of at least 30 cases of P. falciparum infection were identified, including at least 15 complicated cases. In addition 20 cases of P. vivax malarial infection as well as 20 healthy age and sex-matched individuals were taken as two control groups. The outcome measure was the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Diagnosis; Plasmodium falciparum; Parasight-F test.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500008

Rotavirus in adults, Brazil, 2004–2011: G2P[4] dominance and potential impact on vaccination
Provedor de dados: 55
Autores: Luchs,Adriana; Cilli,Audrey; Morillo,Simone Guadagnucci; Carmona,Rita de Cassia Compagnoli; Timenetsky,Maria do Carmo Sampaio Tavares.
Objectives:The aim of this study was to monitor rotavirus (RV) infections in adults &gt;18 years with acute gastroenteritis during 2004–2011 national Brazilian RV surveillance. In addition, to characterize the RV group A (RVA) strains in order to gain insight into the supposed vaccine selective pressure imposed to Brazilian children population.Methods:A total of 2102 convenient fecal specimens were investigated by ELISA, PAGE, and RT-PCR.Results:RV was detected in 203 (9.6%) of 2102 specimens, and showed a marked peak of detection in September. RVA infection was detected in 9.4% (197/2102) and RV group C (RVC) in 0.3% (6/2102). The most frequent genotypes detected in 2004 and 2005 were G9P[8] (38.5%; 5/13) and G1P[8] (54.5%; 6/11), respectively. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus group A; Rotavirus group C; Adults; Vaccination; Brazil.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100053

Rotavirus infection in a tertiary hospital: laboratory diagnosis and impact of immunization on pediatric hospitalization
Provedor de dados: 55
Autores: Pereira,Luciane Aparecida; Raboni,Sonia Mara; Nogueira,Meri B; Vidal,Luine R; Almeida,Sergio Monteiro de; Debur,Maria C; Cruz,Cristina.
BACKGROUND AND OBJECTIVES: Rotavirus (RV) is the main etiological agent of diarrhea in childhood; its laboratory diagnosis is crucial to guide the clinical management and prevention of its spread. RV immunization was introduced in Brazilian 6-month-old children in 2006. The present study was aimed to evaluate three methodologies used for human RV detection in stool samples obtained from patients hospitalized due to gastroenteritis in a teaching hospital and report the impact of RV immunization in hospitalization by diarrhea. METHODS: 293 stool samples collected in the 2001-2008 period were analyzed by enzyme immunoassay (EIA), latex agglutination (LA) and polyacrylamide gel electrophoresis (PAGE). RESULTS: Rotavirus was detected in 34.8% of samples by LA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; Diarrhea; Immunoenzyme techniques; Latex fixation tests; Electrophoresis; Polyacrylamide gel.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300006

Rotavirus infection in children and adult patients attending in a tertiary Hospital of São Paulo, Brazil
Provedor de dados: 55
Autores: Carraro,Emerson; Perosa,Ana Helena Sitta; Siqueira,Itacy; Pasternak,Jacyr; Martino,Marines Dalla Vale.
During the period of January 2003 to December 2005, 3,768 stool samples were received in the Microbiology Laboratory for rotavirus antigen detection from outpatients and inpatients of Albert Einstein Hospital, SP. Fresh stool samples from children and adults were analyzed by two methodologies: during 2003 and 2004 by latex agglutination (Slidex Rotavirus, Biomerieux) and 2005 by an immunochromatographic assay for the combined detection of rotavirus and adenovirus (Vikia Rota-Adeno, Biomerieux). Rotavirus group A was detected in 755 (20%) samples. The annual prevalence was 19.8% in 2003, 21.7% in 2004, and 18.7% in 2005. Rotavirus was detected every month during the period of the study, with peak of positivity between June and August (&gt;35%). The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rotavirus; Gastroenteritis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100010

Rothia aeria endocarditis in a patient with a bicuspid aortic valve: case report
Provedor de dados: 55
Autores: Nicodemo,Antonio Carlos; Gonçalves,Luiz Guilherme; Odongo,Fatuma Catherine Atieno; Martino,Marines Dalla Valle; Sampaio,Jorge Luiz Mello.
Rothia aeria is an uncommon pathogen mainly associated with endocarditis in case reports. In previous reports, endocarditis by R. aeria was complicated by central nervous system embolization. In the case we report herein, endocarditis by R. aeria was diagnosed after acute self-limited diarrhea. In addition to the common translocation of R. aeria from the oral cavity, we hypothesize the possibility of intestinal translocation. Matrix-assisted laser desorption ionization-time of flight mass spectrometry and genetic sequencing are important tools that can contribute to early and more accurate etiologic diagnosis of severe infections caused by Gram-positive rods.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Rothia aeria; Endocarditis; Intestinal translocation; Molecular diagnosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500561

RT-PCR for confirmation of echovirus 30 isolated in Belém, Brazil
Provedor de dados: 55
Autores: Gomes,Maria de Lourdes C.; Ferreira,Lauze Lee A.; Gomes,Rodrigo Henryque; Lamarão,Letícia M.; Silveira,Edna da; Rodrigues,Lílian da Silva; Silva,Cláudio Ferreira da; Almeida,Eduardo Ribeiro de.
Echovirus (Echo) 30 or human enterovirus B is the most frequent enterovirus associated with meningitis cases. Epidemics and outbreaks of this disease caused by Echo 30 have occurred in several countries. In Brazil, Echo 30 has been isolated from sporadic cases and outbreaks that occurred mainly in the south and southeast regions. We used RT-PCR to examine Echo 30 isolates from meningitis cases detected from March 2002 to December 2003 in Belém, state of Pará, in northern Brazil. The patients were attended in a Basic Health Unit (State Health Secretary of Pará), where cerebrospinal fluid (CSF) was collected and stored in liquid nitrogen. Weekly visits were made by technicians from Evandro Chagas Institute to the health unit and samples were stored at -70ºC...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Echovirus 30; Aseptic meningitis; RT-PCR; Belém; Brazil.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400006

Safety and efficacy of a novel drug elores (ceftriaxone + sulbactam + disodium edetate) in the management of multi-drug resistant bacterial infections in tertiary care centers: a post-marketing surveillance study
Provedor de dados: 55
Autores: Chaudhary,Manu; Mir,Mohd Amin; Ayub,Shiekh Gazalla.
Abstract  Objective: In India, Elores (CSE-1034: ceftriaxone + sulbactam + disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections and identify the incidence of adverse events in real clinical settings.  Methods: This Post Marketing Surveillance study was conducted at 17 centers across India and included 2500 patients of all age groups suffering from various bacterial infections and treated with Elores (CSE1034). Information regarding demographic, clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multi-drug resistance; Bacterial infections; IPD; CSE-1034.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400408

Safety aspects of protease inhibitors for chronic hepatitis C: adverse events and drug-to-drug interactions
Provedor de dados: 55
Autores: Teixeira,Rosângela; Nascimento,Yone de Almeida; Crespo,Déborah.
The standard of care therapy of chronic hepatitis C with the combination of pegylated interferon and ribavirin for 24 or 48 weeks was a remarkable accomplishment of the past decade. However, sustained virological responses rates of about 80% (genotypes 2-3) and 50% (geno 3 type 1) were not satisfactory especially for patients infected with genotype 1. Important advances in the biology of HCV have made possible the development of the direct-acting antiviral agents boceprevir and telaprevir with substantial increase in the rates of sustained virological response with shorter duration of therapy for a large number of patients. However, the complexity of triple therapy is higher and several new side effects are expected suggesting greater expertise in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Protease inhibitors; Adverse events; Drug interactions.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200013

Safety, tolerability and side effects of human papillomavirus vaccines: a systematic quantitative review
Provedor de dados: 55
Autores: Gonçalves,Ana Katherine; Cobucci,Ricardo Ney; Rodrigues,Hugo Marcus; Melo,Amanda Gosson de; Giraldo,Paulo César.
Recently, many studies have evaluated HPV vaccine safety and adverse effects. Two vaccine shave been recently evaluated in randomized controlled trials: the bivalent vaccine for HPV 16 and 18 (Cervarix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent vaccine for HPV 6, 11, 16, and 18 (Gardasil, Merck and Co., Inc., Whitehouse Station, NJ). We have performed a systematic review of all randomized controlled trials in which HPV vaccines were compared with placebo regarding safety, tolerability and adverse effects. Studies were searched up to March 2013 in the databases: Pubmed, Embase, Scielo and Cancerlit. Odds Ratios (OR) of most incident adverse effects were obtained. Twelve reports, involving 29,540 subjects, were included. In the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; Vaccines; Adverse effects.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600651

Salivary anti-PGL IgM and IgA titers and serum antibody IgG titers and avidities in leprosy patients and their correlation with time of infection and antigen exposure
Provedor de dados: 55
Autores: Nagao-Dias,Aparecida T.; Almeida,Thereza Lúcia P.; Oliveira,Maria de Fátima; Santos,Rivanda C.; Lima,Ana Laura P.; Brasil,Márcia.
The present work proposed to correlate serum antibody avidity and salivary antibody titers as parameters for time of infection and antigen exposure in a co-hort study evaluating leprosy patients in different periods of treatment. Colorimetric enzyme-immunoassays for salivary antibodies, serum antibody IgG titers and avidities were performed in the samples. Anti-PGL-1 IgA and IgM salivary antibodies were significantly higher in multibacillar (MB-L) patients compared to normal controls (p&lt;0.05), but not when compared to borderline tuberculoid (BT) or to paucibacillar (PB-L) patients (p&gt;0.05). A good correlation was found between salivary anti-PGL-1 IgA and IgM levels in MB-L patients (r=0.41, p&lt;0.01). Two out of 33 tested saliva samples from...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-PGL-1; Avidity; Leprosy; Salivary antibodies.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200009

Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Provedor de dados: 55
Autores: Macedo,Alexandre Casimiro de; Cunha Jr.,José Evandro; Yaochite,Juliana Navarro Ueda; Tavares,Clodis Maria; Nagao-Dias,Aparecida Tiemi.
Abstract Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Leprosy; Salivary antibodies; Phenolic glycolipid-1 antigen; Mycobacterium leprae.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500557

Salmonella Alachua: causative agent of a foodborne disease outbreak
Provedor de dados: 55
Autores: Almeida,Ivete Aparecida Zago Castanheira de; Peresi,Jacqueline Tanury Macruz; Alves,Elisabete Cardiga; Marques,Denise Fusco; Teixeira,Inara Siqueira de Carvalho; Silva,Sonia Izaura de Lima e; Pigon,Sandra Regina Ferrari; Tiba,Monique Ribeiro; Fernandes,Sueli Aparecida.
Objectives: The aim of this study is to report the occurrence of the first outbreak of food poisoning caused by SalmonellaAlachua in Brazil, as well as the antimicrobial susceptibility and the genetic relatedness of SalmonellaAlachua strains isolated from clinical and food samples.Material and methods: To elucidate the outbreak, an epidemiological investigation was carried out, and two samples of common food were tested - mayonnaise salad and galinhada(a traditional Brazilian dish of chicken and rice) - according to the Compendium of methods for the microbiological examination of foods. Five stool samples were tested employing classic methods for the isolation and identification of enterobacteria. Strains of Salmonella were characterized for antibiotic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Foodborne diseases; SalmonellaAlachua; Drug resistance; Brazil.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300233

Salmonella enterica serovar typhi: molecular analysis of strains with decreased susceptibility and resistant to ciprofloxacin in india from 2001-2003
Provedor de dados: 55
Autores: Capoor,Malini R.; Nair,Deepthi; Aggarwal,Pushpa; Mathys,Vanessa; Dehem,Marie; Bifani,Pablo Juan.
Chromosomally-mediated reduced susceptibility to ciprofloxacin narrows the therapeutic options in enteric fever. We made a molecular comparison of clinical isolates of fluoroquinolone-resistant strains of Salmonella enterica serotype Typhi from January 2001 to May 2003; 178 isolates were subjected to antimicrobial susceptibility testing by the Kirby-Bauer method of disk diffusion, and agar dilution was used to determine the minimum inhibitory concentration (MIC) to ciprofloxacin. Nalidixic-acid resistant strains (NARST) were observed in 51% of the isolates, of which 98.9% had decreased susceptibility (MIC&gt;0.125-1µg/mL) to ciprofloxacin. A single strain (4 µg/mL) was resistant to ciprofloxacin and double mutations were found in the gyrA gene (76...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella enterica; S.Typhi; Ciprofloxacin; Resistance.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400011

Salmonella enterica serovar Typhi plasmid pR ST98 enhances intracellular bacterial growth and S. typhi-induced macrophage cell death by suppressing autophagy
Provedor de dados: 55
Autores: He,Peiyan; Wu,Shuyan; Chu,Yuanyuan; Yang,Yanru; Li,Yuanyuan; Huang,Rui.
OBJECTIVES: Plasmid pR ST98 is a hybrid resistance-virulence plasmid isolated from Salmonella enterica serovar Typhi (S. typhi). Previous studies demonstrated that pR ST98 could enhance the virulence of its host bacteria. However, the mechanism of pR ST98-increased bacterial virulence is still not fully elucidated. This study was designed to gain further insight into the roles of pR ST98 in host responses. METHODS: Human-derived macrophage-like cell line THP-1 was infected with wild-type (ST8), pR ST98-deletion (ST8-ΔpR ST98), and complemented (ST8-c-pR ST98) S. typhi strains. Macrophage autophagy was performed by extracting the membrane-unbound LC3-I protein from cells, followed by flow cytometric detection of the membrane-associated fraction of LC3-II....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Plasmid pR ST98; Macrophage; Autophagy; Intracellular bacterial growth; Cell death.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300008

Salpingitis due to Entamoeba histolytica
Provedor de dados: 55
Autores: Calore,E.E; Calore,N.M.P.; Cavaliere,M.J.
We describe the pathology of a unique case of Fallopian tube amebiasis, associated with hydrosalpinx, in a 21-year-old woman. She complained of lower abdominal pain, had a foul-smelling green vaginal discharge and fever during one week. There was a discrete increase in body temperature and a painful abdominal palpation at the lower right side, with signs of local peritoneal irritation. Pathological examination showed a marked dilatation of the fallopian tube and hydrosalpinx. Microscopic examination showed a poorly formed granuloma composed of large macrophages with many Entamoeba histolytica trophozoites inside the fallopian tube. Even though it is a rare disease the correct diagnosis of female genital tract amebiasis is of great importance for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Female genital tract; Amebiasis; Parasites; Fallopian tube; Female genital tract infection; Salpingitis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200007

Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin
Provedor de dados: 55
Autores: Moura,Edmilson Bastos de; Maia,Marcelo de Oliveira; Ghazi,Monalisa; Amorim,Fábio Ferreira; Pinhati,Henrique Marconi.
Disseminated strongyloidiasis is a disease with high mortality rate, especially in immunocompromised individuals. Paralytic ileus and intestinal malabsorption are frequent symptoms caused by this severe disease. As there are no licensed parenteral anthelmintic drugs for human use, off-label formulations are often used in the treatment of this disease. In this case report, the use of subcutaneous ivermectin is described as a successful therapy for this life-threatening infection.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Strongyloidiasis; Immunocompromised host; Sepsis.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500014

Sampling studies to estimate the HIV prevalence rate in female commercial sex workers
Provedor de dados: 55
Autores: Pascom,Ana Roberta Pati; Szwarcwald,Célia Landmann; Barbosa Júnior,Aristides.
INTRODUCTION: We investigated sampling methods being used to estimate the HIV prevalence rate among female commercial sex workers. METHODS: The studies were classified according to the adequacy or not of the sample size to estimate HIV prevalence rate and according to the sampling method (probabilistic or convenience). RESULTS: We identified 75 studies that estimated the HIV prevalence rate among female sex workers. Most of the studies employed convenience samples. The sample size was not adequate to estimate HIV prevalence rate in 35 studies. DISCUSSION: The use of convenience sample limits statistical inference for the whole group. It was observed that there was an increase in the number of published studies since 2005, as well as in the number of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Commercial sex workers; Sampling.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400014

São Paulo urban heat islands have a higher incidence of dengue than other urban areas
Provedor de dados: 55
Autores: Araujo,Ricardo Vieira; Albertini,Marcos Roberto; Costa-da-Silva,André Luis; Suesdek,Lincoln; Franceschi,Nathália Cristina Soares; Bastos,Nancy Marçal; Katz,Gizelda; Cardoso,Vivian Ailt; Castro,Bronislawa Ciotek; Capurro,Margareth Lara; Allegro,Vera Lúcia Anacleto Cardoso.
Urban heat islands are characterized by high land surface temperature, low humidity, and poor vegetation, and considered to favor the transmission of the mosquito-borne dengue fever that is transmitted by the Aedes aegypti mosquito. We analyzed the recorded dengue incidence in Sao Paulo city, Brazil, in 2010-2011, in terms of multiple environmental and socioeconomic variables. Geographical information systems, thermal remote sensing images, and census data were used to classify city areas according to land surface temper- ature, vegetation cover, population density, socioeconomic status, and housing standards. Of the 7415 dengue cases, a majority (93.1%) mapped to areas with land surface temperature &gt;28 ◦ C. The dengue incidence rate (cases per 100,000...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urban heat islands; Land surface temperature; Vegetation cover; Dengue; Aedes aegypti.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200146

Scalp folliculitis with Demodex: innocent observer or pathogen?
Provedor de dados: 55
Autores: Fernandez-Flores,Angel; Alija,Antonio.
Tipo: Info:eu-repo/semantics/other
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200001

Schistosoma mansoni: a rare cause of tubal infection
Provedor de dados: 55
Autores: Faria,CA; Conceição,JCJ; Valadares,TF; Rodrigues,B; Carneiro,L.
S. haematobium is an important cause of urinary schistosomiasis, and symptomatic female genital infection is a common gynecological finding in areas where S. haematobium is prevalent. On the other hand, genital manifestations of intestinal schistosomas as S. mansoni are not frequent or are misdiagnosed. A case of a 40-year-old woman with abnormal uterine bleeding and asymptomatic tubal infection by S. mansoni identified in histological examination is presented.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Schistosomiasis; S. mansoni; Complications.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300015

Schistosomal liver fibrosis and hepatocellular carcinoma - case series of patients submitted to liver transplantation
Provedor de dados: 55
Autores: Filgueira,Norma Arteiro; Saraiva,Camilla Maria de Alencar; Jucá,Norma Thomé; Bezerra,Matheus Filgueira; Lacerda,Claudio Moura.
ABSTRACT Schistosomiasis affects approximately 207 million people in 76 countries. The association between hepatocellular carcinoma and Schistosoma mansoni infection has been investigated. Studies using animal models suggest that the parasite may accelerate the oncogenic process when combined with other factors, such as hepatitis C virus infection or exposure to a carcinogen. Herein, we report a case series of six hepatocellular carcinoma patients from Northeast Brazil, with negative serology for both hepatitis B and C virus, submitted to liver transplantation, whose explant showed evidence of schistosomal liver fibrosis. Since all patients enrolled in this study were submitted to liver transplantation, we were able to access the whole explanted liver and...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Schistosoma mansoni; Hepatocellular carcinoma; Liver transplantation.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400352

Schistosomal peritonitis secondary to perforated appendicitis
Provedor de dados: 55
Autores: Mazigo,Humphrey D; Giiti,Geofrey C; Zinga,Maria; Heukelbach,Jorg; Rambau,Peter.
In Tanzania, Schistosoma mansoni is endemic and causes intestinal schistosomiasis which affects various internal organs. However, worldwide there have been very few reports of cases of peritonitis due to schistosomal appendicitis. Here we report a rare case of schistosomal appendicitis with peritonitis in a 33 year-old male patient who recovered quickly after surgery
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Appendicitis; Peritonitis; Schistosoma mansoni; Tanzania.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600013

Sclerosing encapsulating peritonitis in HIV-infected patient on dialysis
Provedor de dados: 55
Autores: Böhlke,Maristela; Caruso,Paulo; Uliano,Gustavo.
Tipo: Info:eu-repo/semantics/article
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100094

Screening for hepatitis B virus in Maracanã workers
Provedor de dados: 55
Autores: Bottecchia,Marcelle; Miguel,Juliana Custódio; Silva,Elisangela Ferreira da; Ginuíno,Cleber Ferreira; Souza,Marcia Terezinha Baroni de Moraes e.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100100

Scrotal swelling in a farmworker with paracoccidioidomycosis
Provedor de dados: 55
Autores: Parente,Daniella Braz; Louza,Guilherme Felix; Carneiro,Leonardo Hoehl; Zanetti,Gláucia; Marchiori,Edson.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200155

Search for Mycobacterium leprae in wild mammals
Provedor de dados: 55
Autores: Pedrini,Sílvia Cristina Barboza; Rosa,Patrícia Sammarco; Medri,Ísis Meri; Mourão,Guilherme; Bagagli,Eduardo; Lopes,Carlos Alberto de Magalhães.
Leprosy is still a worldwide public health problem. Brazil and India show the highest prevalence rates of the disease. Natural infection of armadillos Dasypus novemcinctus with Mycobacterium leprae has been reported in some regions of the United States. Identification of bacilli is difficult, particularly due to its inability to grow in vitro. The use of molecular tools represents a fast and sensitive alternative method for diagnosis of mycobacteriosis. In the present study, the diagnostic methods used were bacilloscopy, histopathology, microbiology, and PCR using specific primers for M. leprae repetitive sequences. PCR were performed using genomic DNA extracted from 138 samples of liver, spleen, lymph nodes, and skin of 44 D. novemcinctus, Euphractus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dasypus novemcinctus; Euphractus sexcinctus; Cabassous tatouay; Mycobacterium leprae; Eco-epidemiology; Wild mammals.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100010

Secondary syphilis in the oral cavity and the role of the dental surgeon in STD prevention, diagnosis and treatment: a case series study
Provedor de dados: 55
Autores: Seibt,Creta Elisa; Munerato,Maria Cristina.
Abstract Syphilis is an infectious disease caused by the bacterium Treponema pallidum. Syphilis has three clinical stages and may present various oral manifestations, mainly at the secondary stage. The disease mimics other more common oral mucosa lesions, going undiagnosed and with no proper treatment. Despite the advancements in medicine toward prevention, diagnosis, and treatment syphilis remains a public health problem worldwide. In this sense, dental surgeons should be able to identify the most common manifestations of the disease in the oral cavity, pointing to the role of this professional in prevention and diagnosis. This study describes a case series of seven patients with secondary syphilis presenting different oral manifestations.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Oral manifestations; Secondary syphilis; Treponema pallidum.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400393

Secondary syphilis with oral manifestation
Provedor de dados: 55
Autores: Safe,Izabella Picinin; Maia,Daniela Cristina Caetano.
Tipo: Info:eu-repo/semantics/report
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100095

Secretory immunoglobulin A: a protective factor in the genital mucosa
Provedor de dados: 55
Autores: Giraldo,Paulo C.; Gonçalves,Ana Katherine; Eleutério Junior,José.
The genital mechanisms of defense are not well understood and are therefore ignored during therapy. This fact results in a great number of cases of treatment failure. The mucosa is an important protective factor of the genital female system, through self-defense mechanisms, and secretor antibodies (immunoglobulin A). The lymphoid tissue exerts protective anti-inflammatory activity, besides inhibiting microorganism adherence, neutralizes viruses and toxins and stabilizes the mucosal flora. Although certain microorganisms, such as viruses and fungus, are controlled by cellular immunity, secretory IgA can also exert an important role in the control of these agents.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vaginal immunity; Genital infections; HPV; Candida albicans; Secretory IgA.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400002

Secular trends of candidemia at a Brazilian tertiary care teaching hospital
Provedor de dados: 55
Autores: Braga,Paula Rocha; Cruz,Isabela L.; Ortiz,Isadora; Barreiros,Gloria; Nouér,Simone A.; Nucci,Marcio.
ABSTRACT  Background Candidemia is the most frequent invasive fungal disease in hospitalized patients, and is associated with high mortality rates. The main objective of this study was to evaluate changes in the epidemiology of candidemia at a tertiary care hospital in a 21-year period.  Methods We evaluated all episodes of candidemia diagnosed between 1996 and 2016 at a University-affiliated tertiary care hospital in Brazil. We arbitrarily divided the study period in 3: 1996-2002 (period 1), 2003-2009 (period 2) and 2010-2016 (period 3). Incidence rates were calculated using hospital admissions as denominator.  Results We observed 331 episodes of candidemia. The incidence was 1.30 episodes per 1000 admissions, with no significant change over time. Candida...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidemia; Epidemiology; Fungemia; Candida.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400273

Selective versus non-selective culture medium for group B streptococcus detection in pregnancies complicated by preterm labor or preterm-premature rupture of membranes
Provedor de dados: 55
Autores: Nomura,Marcelo Luís; Passini Júnior,Renato; Oliveira,Ulysses Moraes.
The objective of this study was to identify group B streptococcus (GBS) colonization rates and compare detection efficiency of selective versus non-selective culture media and anorectal versus vaginal cultures in women with preterm labor and preterm-premature rupture of membranes (PROM). A prospective cohort study of 203 women was performed. Two vaginal and two anorectal samples from each woman were collected using sterile swabs. Two swabs (one anorectal and one vaginal) were placed separately in Stuart transport media and cultured in blood-agar plates for 48 hours; the other two swabs were inoculated separately in Todd-Hewitt selective media for 24 hours and then subcultured in blood-agar plates. Final GBS identification was made by the CAMP test. A...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus agalactiae; Culture media; Premature rupture of membranes; Preterm labor.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400006

Self-reported adverse reactions among patients initiating antiretroviral therapy in Brazil
Provedor de dados: 55
Autores: Pádua,Cristiane A. Menezes de; César,Cibele C.; Bonolo,Palmira F.; Acurcio,Francisco A.; Guimarães,Mark Drew C.
A cross-sectional analysis was carried out to describe adverse reactions to antiretroviral therapy (ART) reported by HIV-infected patients initiating treatment at two public health AIDS referral centers in Belo Horizonte, Brazil, 2001-2003 and to verify their association with selected variables. Adverse reactions were obtained through interview at the first follow-up visit (first month) after the antiretroviral prescription. Socio-demographic and behavioral variables related to ART were obtained from baseline and follow-up interviews and clinical variables from medical charts. Patients with four or more reactions were compared to those with less than four. Odds ratio with 95% confidence interval were estimated using logistic regression model for both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Adverse reactions; Self-report.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100007

Self-reported syphilis and associated factors among Brazilian young adults: findings from a nationwide survey
Provedor de dados: 55
Autores: Kops,Natália Luiza; Bessel,Marina; Hohenberger,Glaucia F.; Benzaken,Adele; Wendland,Eliana.
Abstract The aim of this study was to evaluate self-reported syphilis and associated factors in sexually active young adults (16-25 years old) in the Public Health System in Brazil. This was a cross-sectional study with 8071 participants recruited from 119 primary care units. Of these, 224 (2.86%, 95% CI 2.29-3.43%) reported having the disease. Age, lower socio-economic class, being a smoker, not using a condom at first sexual intercourse, and ever had a same-sex sexual experience were associated with syphilis. The results reinforce the importance of implementing strategies focused on socio-economic class and early sexual education that encourage condom use from the beginning of sexual activity.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Syphilis; Epidemiology; Primary care; Public health.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400274

Sensitivity pattern of Salmonella serotypes in Northern India
Provedor de dados: 55
Autores: Gautam,Vikas; Gupta,Naveen Kumar; Chaudhary,Uma; Arora,D. R.
BACKGROUND: Enteric fever continues to be a major public health problem, especially in the developing countries of the tropics. We determined the incidence of Salmonella bloodstream infections and their antimicrobial resistance patterns from May to August in the years 1997-2001 in Haryana, a large state of India. The minimum inhibitory concentration (MIC) was also determined for 60 isolates of S. typhi to various commonly used antimicrobial agents. MATERIAL AND METHODS: Blood cultures of 6,956 patients (PUO/septicemia) were processed by standard procedures and the Salmonella spp. isolates were identified with specific antisera and with standard biochemical tests. Antimicrobial susceptibilities were determined by Stokes disc diffusion method. The MIC of 60...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Salmonella; Multidrug resistance.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600003

Sentinel site surveillance of nontuberculous mycobacteria pulmonary diseases in Zhejiang, China, 2011-2013
Provedor de dados: 55
Autores: Bi,Sheng; Xu,Kai-jin; Ji,Zhong-kang; Zheng,Bei-wen; Sheng,Ji-fang.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600670

Sentinel surveillance of influenza and other respiratory viruses, Brazil, 2000-2010
Provedor de dados: 55
Autores: Freitas,Felipe Teixeira de Mello.
There are scanty data on the epidemiology of influenza and other respiratory viruses in South America and Brazil. The aim of this study was to summarize the data from the Brazilian surveillance system of influenza and other respiratory viruses and discuss the patterns of viral circulation. The system is based on detecting cases of influenza-like illness in sentinel sites and weekly collection of five nasopharyngeal secretions samples, which are processed in state public health laboratories for respiratory viruses by indirect immunofluorescence assay. Data from 2000 to 2010 were described over time, by region, gender, and age group, and an analysis of Spearman correlation was performed between monthly influenza detection and rainfall and temperature data in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza; Respiratory syncytial virus; Public health surveillance; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100010

SENTRY antimicrobial surveillance program report: latin american and brazilian results for 1997 through 2001
Provedor de dados: 55
Autores: Sader,Helio S.; Jones,Ronald N.; Gales,Ana C.; Silva,Juliana B.; Pignatari,Antonio C.
The alarming emergence and spread of antimicrobial resistance among common bacteria threatens the effectiveness of therapy for many infections. Surveillance of antimicrobial resistance is essential to identify the major problems and guide adequate control measures. Several resistance surveillance programs have been implemented in North America and Europe in the last decade; however, very few programs have assessed antimicrobial resistance in Latin American countries. The SENTRY Antimicrobial Surveillance Program was initiated in 1997 and represents the most comprehensive surveillance program in place at the present time worldwide. The SENTRY Program collects consecutive isolates from clinically documented infections in more than 80 medical centers...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SENTRY; Antimicrobial resistance; Nosocomial infection; Surveillance; Latin America.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100004

Sepsis by Chromobacterium violaceum: first case report from Colombia
Provedor de dados: 55
Autores: Díaz Pérez,Julio Alexander; García,Jorge; Rodriguez Villamizar,Laura Andrea.
Chromobacterium violaceum is found in tropical and subtropical regions; it is the only Chromobacterium species pathogenic for humans. Due to its rare presentation, physicians often ignore the importance of this pathogen. We report a fulminant fatal case of bacteremia in a 38-year-old Colombian man. The clinical manifestations were fever, thoracic pain, respiratory failure and death. His condition, from the beginning of clinical diagnosis, went into continuous deterioration, till his death, within a few days after the symptoms began. Two hemocultures isolated C. violaceum. We conclude that doctors should consider this differential diagnosis in patients with systemic inflammatory response syndrome, with continuous deterioration.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Chromobacterium violaceum; Bacteremia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400016

Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute lymphoid leukemia patient
Provedor de dados: 55
Autores: Vicari,Perla; Pinheiro,Ronald Feitosa; Chauffaille,Maria de Lourdes Lopes Ferrari; Yamamoto,Mihoko; Figueiredo,Maria Stella.
Fungal infections caused by Candida species have increased in incidence during the past two decades in England, North America and Europe. Candidal arthritis is rare in patients who are not intravenous drug users or are who not using a prostheses. We report the case of a 24-year-old man with acute lymphoid leukemia, who developed Candida tropicalis arthritis during an aplastic period after chemotherapy. This is the eighth case described in the literature of C. tropicalis causing arthritis without intra-articular inoculation. We call attention to an unusual first sign of fungal infection: septic arthritis without intra-articular inoculation. However, this case differs from the other seven, since despite therapy a fast and lethal evolution was observed. We...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Septic arthritis; Candida tropicalis; Fungal infections; Candida tropicalis arthritis; Systemic candidiasis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600012

Septicemia caused by Vibrio cholerae O1 biotype El Tor, in São Paulo, Brazil
Provedor de dados: 55
Autores: Abboud,C.S.; Ferreira,C.E.S.; Barbosa,V.L.B.; Araújo,D.A.C.; Zandonadi,E.C.; Pasternak,J.
We reported a case of septicemia by Vibrio cholerae O1, in São Paulo, Brazil. A 70-year-old male patient, living in an urban area, entered the emergency service having sepsis, dying 12 hours later. Blood culture was positive for Vibrio cholerae O1. This is the first case of bacteremia by Vibrio cholerae O1 reported in South America.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vibrio cholerae O1; El Tor; Septicemia.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200028

Septicemia in an immunocompetent adult in the Czech Republic caused by Corynebacterium diphtheriae nontoxigenic strain biotype mitis: emergence of invasive cases in Western Europe
Provedor de dados: 55
Autores: Massmann,Ricardo; Zavadilová,Jana; Drozenová,Jana; Fiksa,David; Smíšková,Dita.
Tipo: Info:eu-repo/semantics/other
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100089

Sequence analysis of genes associated with resistance to chloroquine and sulphadoxine pyrimethamine in P. falciparum and P. vivax isolates from the Bannu district of Pakistan
Provedor de dados: 55
Autores: Khatoon,Lubna; Baliraine,Frederick N.; Malik,Salman A.; Yan,Guiyun.
Plasmodium vivax and Plasmodium falciparum are becoming resistant to drugs including antifolates, sulphonamides and chloroquine. This study was focused at sequence analysis of resistant genes of these parasites against sulphadoxine-pyrimethamine and chloroquine, from Bannu, Pakistan. Known mutations were detected at codons 57, 58 and 117 of pvdhfr gene of P. vivax, while none of the isolates had any pvdhps mutation. Similarly P. falciparum isolates exhibited double 59R + 108N mutations in pfdhfr, and single 437G in pfdhps thus demonstrating the existance of triple mutant 59R + 108N + 437G haplotype in this region. The key chloroquine resistance mutation, 76T in pfcrt was observed in 100% of the P. falciparum isolates, with haplotype SVMNT which is also...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Plasmodium vivax; Plasmodium falciparum; Sequence analysis; Pakistan.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500013

Serodiagnosis of tuberculosis: specific detection of free and complex-dissociated antibodies anti-mycobacterium tuberculosis recombinant antigens
Provedor de dados: 55
Autores: Imaz,María Susana; Schmelling,María Fernanda; Kaempfer,Susanne; Spallek,Ralph; Singh,Mahavir.
The diagnostic test characteristics of detecting free and complex-dissociated IgG to three recombinant antigens of Mycobacterium tuberculosis (38-kDa, Ag16 and Ag85B), singly and in combination, were evaluated in sera from 161 tuberculous patients [smear-positive pulmonary TB (50), smear-negative pulmonary TB (pTBsm-) (60) and extrapulmonary TB (51)) and 214 control patients (mycobacteriosis (14), mycoses(14), leprosy(4), other underlying diseases (82) and healthy people (100)]. The individual antigens ranged from 25% to 42% in sensitivity and from 93% to 96% in specificity, while considering free IgG response. Addition of complex-dissociated antibodies against each individual antigen improved the sensitivity up to 55%. The number and levels of specific...
Tipo: Info:eu-repo/semantics/article
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300014

Seroepidemiological survey of transmissible infectious diseases in a portuguese prison establishment
Provedor de dados: 55
Autores: Marques,Nuno Miguel da Silva; Margalho,Renata; Melo,Maria João; Cunha,José Gabriel Saraiva da; Meliço-Silvestre,António Abel.
A cross-sectional study was conducted in 151 (71.6%) of 211 male inmates of a regional Portuguese prison in order to establish the seroprevalence for viral hepatitis (HAV, HBV, HCV), human immunodeficiency virus (HIV), syphilis and herpes simplex virus (HSV-1 and HSV-2) and to analyze some psychosocial and criminal characteristics. Mean age was 34 years. Anti-HAV was positive in 69.5% (n = 105) and in 34.4% (n = 52) for anti-HCV. One (0.7%) person had HBsAg and 29 (19.2%) had laboratory markers of past HBV infection. Non-immune inmates for HBV were 40.4% (n = 61). Syphilis was diagnosed in 6.0% (n = 9). The rate of HIV infection was 6.6% (n = 10; all HIV-1). The seropositivity of HSV-2 was 19.9% (n = 30) and of HSV-1 was 82.1% (n = 124). Alcohol dependence...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mass screening; Communicable diseases; Prisons; Drug users.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300016

Seroepidemiology of hepatitis E virus in Western Iran
Provedor de dados: 55
Autores: Raoofi,Rahim; Nazer,Mohamad Reza; Pournia,Yadollah.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300017

Serological and molecular detection of HHV-8 in Brazilian populations
Provedor de dados: 55
Autores: Cunha,Andréa Mendonça Gusmão; Costa,Sandra Cecília Botelho; Costa,Fernando Ferreira; Caterino-de-Araújo,Adele; Castro Filho,Bernardo Galvão.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500024

Serological evidences suggest Borrelia burgdorferi sensu lato infection in Cuba
Provedor de dados: 55
Autores: Rodríguez,Islay; Fernández,Carmen; Sánchez,Lizet; Martínez,Bárbara; Siegrist,Hans H.; Lienhard,Reto.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400022

Serological markers of hepatitis A, B and C viruses in rural communities of the semiarid Brazilian Northeast
Provedor de dados: 55
Autores: Almeida,Delvone; Tavares-Neto,José; Vitvitski,Ludmila; Almeida,Alessandro; Mello,Caroline; Santana,Diana; Tatsch,Fernando; Paraná,Raymundo.
In the village of Cavunge, located in a dry tropical, semiarid rural region of the state of Bahia, Brazil, a sentinel study on viral hepatitis is underway. We report on the first part of the study. The objective of this study was to determine the prevalence of serological markers for hepatitis A, B and C in the village. Cross sectional study. Blood samples were tested for serological markers of hepatitis A (HAV), B (HBV) and C (HCV) through ELISA-III assay. In HBsAg and anti-HCV carriers, HCV-RNA and HBV-DNA were checked by PCR. The prevalence of anti-HAV IgG was 83.3% (1,210/1,452), being higher among residents from the village (87.4%) than in residents from the rural area (79.5%); it also higher among individuals older than 10 years of age. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis A; Hepatitis B; Hepatitis C; Epidemiology; Brazil.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500003

Serological survey of Chikungunya virus in Ilorin Metropolis, Nigeria
Provedor de dados: 55
Autores: Kolawole,Olatunji Matthew; Bello,Kizito Eneye; Seriki,Adetola Adebimpe; Irekeola,Ahmad Adebayo.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300365

Seronegative cat-scratch disease diagnosed by PCR detection of Bartonella henselae DNA in lymph node samples
Provedor de dados: 55
Autores: Chondrogiannis,Konstantinos; Vezakis,Antonios; Derpapas,Michael; Melemeni,Aikaterini; Fragulidis,Georgios.
Cat scratch disease (CSD), the typical clinical manifestation of Bartonella infections usually follows a typical benign self-limited course. Nevertheless, a variety of unusual clinical manifestations and confusing imaging features can lead to misinterpretations and render the disease a diagnostic dispute. Routine laboratory tests exhibit varying reported sensitivity and are usually unhelpful in diagnosis, as serology fails in terms of specificity and/or sensitivity. Herein we report a case of seronegative Bartonella infection presenting as symptomatic suppurative lymphadenitis with abscess formation, which was surgically drained. Diagnosis was established by PCR analysis from lymph nodes samples obtained during the procedure. PCR detection of specific DNA...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Polymerase chain reaction; Cat-scratch disease; Bartonella henselae.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100019

Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation
Provedor de dados: 55
Autores: Brandão,Luciana Gomes Pedro; Brasil,Pedro Emmanuel Alvarenga Americano do; Oliveira,Silas de Souza; Silva,Edson Elias da; Lopes,Guilherme Santoro.
ABSTRACT In the current effort to eliminate polio from the world, it is important to recognize and vaccinate susceptible groups, especially immunocompromised patients living in countries where attenuated polio vaccine is still used. In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Among the first 100 patients enrolled in this study, only seven adult SOT candidates had proven polio vaccination...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Poliomyelitis; Immunity; Solid organ transplantation.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200150

Seropositivity rates for toxoplasmosis, rubella, syphilis, cytomegalovirus, hepatitis and HIV among pregnant women receiving care at a public health service, São Paulo state, Brazil
Provedor de dados: 55
Autores: Gonçalves,Márcia Aparecida dos Santos; Matos,Cinara de Cássia Brandão de; Spegiorin,Lígia Cosentino Junqueira Franco; Oliani,Denise Cristina Mós Vaz; Oliani,Antonio Hélio; Mattos,Luiz Carlos de.
Infectious and parasitic diseases affecting women during their reproductive age may result in vertical transmission. The aim of this study was to determine the seroprevalence for TORSCH among pregnant women receiving care at a university hospital. Records of 574 pregnant women who received medical attention from January 2006 to December 2007 were assessed. The mean age was 27.2 ± 6.5 years ranging from 13 to 44. The results of the immunodiagnostic tests were: 62.0% (345/556) for IgG and 3.4% (19/556) for IgM anti-T. gondii; 93.1% (433/465) for IgG and 0.6% (3/465) for IgM anti-rubella; 0.9% (5/561) for VDRL; 1.8% (10/554) for HBsAg; 0.7% (4/545) for anti-HCV and 2.1% (11/531) for HIV. In conclusion, the results of immunodiagnostic tests for the TORSCH...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Toxoplasmosis; Rubella; Infectious disease transmission; Vertical; Pregnancy complications; Infectious; Hepatitis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600009

Seroprevalence and risk factors associated with Helicobacter pylori infection in blood donors in Salvador, Northeast-Brazil
Provedor de dados: 55
Autores: Lyra,Andre C.; Santana,Genoile; Santana,Nelma; Silvany-Neto,Anibal; Magalhães,Emilia; Pereira,Eduardo M.; Mascarenhas,Ramiro; Lyra,Marcos C.; Veiga,Andrea; Ferreira,Karina; Zaterka,Schilioma; Lyra,Luiz G.
Helicobacter pylori plays an important role in the etiology of peptic ulcer disease. Its prevalence appears to be higher in developing countries. We evaluated the seroprevalence of H. pylori and risk factors associated with infection in voluntary blood donors who attended the main blood center of the city of Salvador, Brazil. The subjects responded to an epidemiological questionnaire, with information about sex, age, race, lifestyle, social-economic level indicators, and residence and hygiene conditions. Anti-H. pylori antibody was determined by ELISA (Cobas Core, Roche). Three hundred and seven subjects were included in the study. Anti-H. pylori antibody results were indeterminate in 33 individuals (10.8%), who were excluded from analysis. Among the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: H. pylori; Seroprevalence; Risk factors; Brazil.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500009

Seroprevalence of chikungunya virus infection in five hospitals within Anyigba, Kogi State of Nigeria
Provedor de dados: 55
Autores: Omatola,Cornelius A.; Onoja,Bernard A.; Fassan,Peter K.; Osaruyi,Stephanie A.; Iyeh,Mercy; Samuel,Matthew A.; Haruna,Peace U.
ABSTRACT Febrile illnesses in developing countries are often misdiagnosed as malaria or typhoid fever. Although arboviral infections have similar clinical symptoms, they are usually not screened because of limited resources and the fact that there are several viruses in this group. Chikungunya virus (CHIKV) has been isolated in parts of Nigeria, but there is no documented evidence of the infection in Kogi State. This study determined seroprevalence of active and past CHIKV infection among febrile patients who tested negative for malaria and typhoid fever. Sera from 243 febrile patients were screened for CHIKV IgG and IgM using an immunochromatographic test kit. Clinical and socio-demographic variables were collected using a structured questionnaire. Recent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chikungunya; Fever; Seroprevalence; IgM; IgG; Nigeria.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100001

Seroprevalence of cytomegalovirus infection among pregnant women in Eastern Iran
Provedor de dados: 55
Autores: Bagheri,Leila; Mokhtarian,Hossein; Sarshar,Narges; Ghahramani,Mohammad.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400020

Seroprevalence of HbsAg, anti-HBc and anti-HCV in Southern Brazil, 1999-2001
Provedor de dados: 55
Autores: Rosini,Nilton; Mousse,Donaida; Spada,Celso; Treitinger,Arício.
The prevalence of infection by the hepatitis B (HBV) and C (HCV) viruses varies among geographical regions. We evaluated 263,795 blood donor samples collected from 1999-2001 in various cities in the state of Santa Catarina to determine the prevalence of HbsAg, anti-HBc and anti-HCV markers. The markers were analyzed by immunoenzymatic tests, as determined by the Ministry of Health, and the data were obtained from blood banks and from ANVISA (the Brazilian National Agency for Sanitary Vigilance). There was a significant reduction in the mean frequency of HbsAg and anti-HBc during the study period, from 0.98% to 0.64% and from 8.83% to 5.35%, respectively, though they varied considerably among the different regions. There was also a decrease in the mean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood donors; Hepatitis B; Hepatitis C; HbsAg; Anti-HBc; Anti-HCV.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400006

Seroprevalence of hepatitis A antibodies in a group of normal and Down Syndrome children in Porto Alegre, Southern Brazil
Provedor de dados: 55
Autores: Ferreira,Cristina Targa; Leite,Júlio César; Taniguchi,Adriano Nori R.; Vieira,Sandra Maria G.; Pereira-Lima,Jorge; Silveira,Themis Reverbel da.
The high incidence of Hepatitis A and B in institutionalized patients with Down Syndrome (DS) is not fully understood. Under poor hygienic conditions, immunological alterations might predispose individuals to these infections. Sixty three DS children between 1 and 12 years old living at home with their families were examined for anti-HAV and compared to age-matched controls (64 healthy children). This cross-sectional study was carried out from May, 1999, to April, 2000, at the Hospital de Clínicas of Porto Alegre, southern Brazil. Groups were compared in terms of age, sex, skin color, and family income (&gt; R$ 500 and &lt; R$ 500/ month) by the chi-square test, with Yates' correction and for the prevalence of anti-HAV (Fisher's exact test). In the DS...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Down syndrome; Hepatitis A; Seroprevalence.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500003

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?
Provedor de dados: 55
Autores: Oliveira,Luiz Carlos Marques de; Comácio,Samantha Martins; Santos,Júlia de Fátima Gonçalves.
BACKGROUND: Patients with chronic liver disease have a higher risk of fulminant hepatitis when infected with hepatitis A virus, and vaccination of these patients against such infection is recommended. In Brazil, mainly in the South and Southeast regions, the epidemiology of hepatitis A (HA) has shifted from high to intermediate endemicity, which would have implication on policy of HA vaccination for these populations. OBJECTIVE: To verify the prevalence of HA immunity in adult patients with liver cirrhosis (LC), in Uberlândia MG, a city of Southeastern Brazil. METHODS: Between December 2005 and December 2006, 106 patients with LC were consecutively evaluated. In addition, 75 individuals without LC or alcoholism were evaluated (control group - CG). RESULTS:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis A vaccines; Hepatitis A virus; Liver cirrhosis; Prevalence.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300015

Seroprevalence of hepatitis A immunity among children and adolescents in two cities of the Triângulo Mineiro region, State of Minas Gerais, Brazil
Provedor de dados: 55
Autores: Gonçalves,Alana Arantes Santos; Oliveira,Luiz Carlos Marques de.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500021

Seroprevalence of hepatitis B and C in Brazilian army conscripts in 2002: a cross-sectional study
Provedor de dados: 55
Autores: Toledo Jr.,Antonio C.; Greco,Dirceu B.; Felga,Marcelo; Barreira,Dráurio; Gadelha,Maria de Fátima S.; Speranza,Francisco A.B.
Hepatitis B and C constitute important public health problems worldwide. In Brazil, studies on prevalence of viral hepatitis have local and regional characteristics; consequently it is difficult to define the national epidemiological situation. Our objective was to evaluate the seroprevalence of hepatitis B and C in conscripts of the Brazilian Army. A transversal study among males aged 17 to 22 years was conducted nationwide. After informed consent, each volunteer filled in a social-behavioral questionnaire and had blood drawn to test for HBsAg and anti-HCV. A total of 7,372 volunteers were evaluated in the second half of 2002. The prevalence of HBsAg was 2.6% (95% confidence interval: 2.2, 3.0) and that of anti-HCV was 1.5% (95% confidence interval: 1.2,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Viral hepatitis; Seroepidemiological studies; Cross-sectional study; Prevalence; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500004

Seroprevalence of hepatitis B and C in the Western Brazilian Amazon region (Rio Branco, Acre): a pilot study carried out during a hepatitis B vaccination program
Provedor de dados: 55
Autores: Tavares-Neto,J.; Almeida,D.; Soares,M. C.; Uchoa,R.; Viana,S.; Darub,R.; Farias,E.; Rocha,G.; Vitvitski,L.; Paraná,R.
In 1999, on the occasion of the application of the first vaccine dose during the state vaccination campaign against hepatitis B virus (HBV), 390 individuals from the town of Rio Branco, Acre, aged two or more years were selected for the determination of the seroprevalence of HBV and HCV. HBV markers (HBsAg, anti-HBs, and anti-HBc IgG) were determined on this occasion and anti-HBs antibodies were also assessed 30 days after the third vaccine dose. At the time of vaccination, 39% of the individuals were still susceptible to HBV, while 61% presented serologic evidence of previous HBV contact or previous vaccination. The individuals with previous HBV contact were significantly older (p&lt;0.001) than those without HBV markers. Of the 192 individuals who...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B vaccination; Amazonia; Hepatitis B; Hepatitis C; Epidemiology.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200003

Seroprevalence of hepatitis B and hepatitis C markers among children and adolescents in the south brazilian region: metropolitan area of Florianópolis, Santa Catarina
Provedor de dados: 55
Autores: Voigt,Andréia Royer; Strazer Neto,Miguel; Spada,Celso; Treitinger,Arício.
Hepatitis B and C are important causes of morbidity and mortality worldwide. In Brazil, according to the Ministry of Health, about 15% of population is infected by hepatitis B virus (HBV) and less than 1% by hepatitis C virus (HCV). Nevertheless, the age-specific prevalence of HBV and HCV markers remains unknown. This study aimed to determine the seroprevalence of HBV and HCV markers of infection and immunity in children and adolescents between 10 to 16 years old who live in the metropolitan area of Florianópolis, state of Santa Catarina, South of Brazil. Three hundred and eighty four individuals were enrolled in this study. Serological markers for HBV and HCV (HBsAg, total anti-HBc, anti-HBc IgM, anti-HBs and anti-HCV) were determined through...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HCV; HBsAg; Anti-HBs; Anti-HBc; Anti-HCV; Seroprevalence.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100012

Seroprevalence of hepatitis B surface antigen and its correlation with risk factors among new recruits in Turkey
Provedor de dados: 55
Autores: Altay,Tulin; Uskun,Ersin; Akcam,Fusun Zeynep.
OBJECTIVES: The objective of this cross-sectional study was to determine seroprevalence of hepatitis B surface antigen and related risk factors among new recruits in a military unit in Turkey. METHODS: Eight thousand five hundred eighty-nine newly-recruited soldiers were enrolled in the study. Blood samples were drawn from them between January 2006 and December 2006 and ELISA technique was applied to the samples. In addition, questions on the risk factors of hepatitis B exposure were asked to the participants in the survey. RESULTS: The results demonstrated that HBsAg seroprevalence was 2.8%. Further survey results indicated that seropositivity increased depending on certain risk factors. In multiple regression analysis, significant correlations were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Seroprevalence; Hepatitis B surface antigen; HBsAg.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400005

Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil
Provedor de dados: 55
Autores: Bricks,Guilherme; Senise,Jorge Figueiredo; Pott Junior,Henrique; Grandi,Giuliano; Passarini,Amanda; Caldeira,Débora Bellini; Carnaúba Junior,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.
ABSTRACT  Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors.  Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).  Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Brazil; Seroprevalence.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200085

Seroprevalence of HIV among blood donors, antenatal women and other patients in a tertiary hospital in Nigeria
Provedor de dados: 55
Autores: Olajubu,F. A.; Osinupebi,O. A.; Deji-Agboola,M.; Jagun,E.O.
HIV/AIDS continues to remain a nightmare in the developing nations of the world especially in Nigeria, where about 2.9 million people are living with this problem. This study aimed at determining the sero-prevalence of HIV among both patients and blood donors at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Samples were collected between January 1st, 2005 and December, 31st 2006 and were screened using two rapid test kits, with two different principles (enzymatic and agglutination). Samples positive to the two methods were taken as truly sero-positive. The seropositive rate among blood donors, antenatal women, in- and out patients were, 3.2%, 6.9% and 17.5% respectively. There were five cases of positivity to both HIV I and II....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Blood donor; Antenatal; Sagamu; Nigeria.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400008

Seroprevalence of human cysticercosis in Jataí, Goiás state, Brazil
Provedor de dados: 55
Autores: Guarda,Kaliny Xavier da; Costa-Cruz,Julia Maria; Barcelos,Ivanildes Solange da Costa.
ABSTRACT The Taenia solium cysticercosis affects millions of people worldwide and is considered a public health problem, especially in developing countries. The diagnosis of neurocysticercosis is complex and involves the analysis of epidemiological, clinical, neuroimaging, and immunological host data. Neurocysticercosis is endemic in Brazil, and is related to the cause of death mainly in the Southeast, South, and Central-West regions. The objective of this study was to determine the seroprevalence of cysticercosis in inhabitants of the city of Jataí, Goiás, in the Central-West region of Brazil from April to August 2012. A total of 529 serum samples were analyzed by enzyme-linked immunosorbent assay for detecting IgG antibodies against T. solium larvae, and...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cysticercosis; Taenia solium; Epidemiology; Diagnosis; Brazil.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200146

Serosurvey for canine visceral leishmaniasis in rural and urban areas of the Brazilian Legal Amazon
Provedor de dados: 55
Autores: Guimarães,Andresa; Raimundo,Juliana Macedo; Santos,Helciléia Dias; Machado,Rosangela Zacarias; Baldani,Cristiane Divan.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200207

Serotype changes and antimicrobial nonsusceptibility rates of invasive and non-invasive Streptococcus pneumoniae isolates after implementation of 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in Bulgaria
Provedor de dados: 55
Autores: Setchanova,Lena; Murdjeva,Marianna; Stancheva,Iglika; Alexandrova,Alexandra; Sredkova,Maria; Stoeva,Temenuga; Yoneva,Magda; Kurchatova,Anna; Mitov,Ivan.
Abstract The 10-valent pneumococcal conjugate vaccine (PCV10) has been included in Bulgarian Childhood Immunization Program since 2010. This study aimed to assess serotype distribution and antimicrobial resistance of 198 invasive and non-invasive Streptococcus pneumoniae strains that had been isolated in Bulgaria during 2011-2016 from patients with invasive (IPD) and non-invasive (NIPD) pneumococcal diseases. The most common invasive serotypes were 3 (10.1%), 19F (4.0%), and 7F (3.0%). A significant decrease in the proportion of invasive vaccine types (VTs) from 64.2% to 35.2% was found in comparison with pre-vaccine era. The most common serotypes among middle ear fluids were 3, 19A and 19F (5.6% each), and VTs fell down from 66.4% to 40.0% in post-PCV10...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Invasive and non-invasive isolates; Serotypes; Antimicrobial nonsusceptibility.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400433

Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae causing noninvasive diseases in a Children's Hospital, Shanghai
Provedor de dados: 55
Autores: Pan,Fen; Han,Lizhong; Kong,Jing; Wang,Chun; Qin,Huihong; Xiao,Shuzhen; Zhu,Junying; Zhang,Hong.
Background: Streptococcus pneumoni ae, which cause noninvasive pneumococcal diseases, severely impair children's health. This study analyzed serotype distribution and antimicrobial resistance of S. pneumoni ae from January 2012 to December 2012 in a Children's Hospital, Shanghai.  Methods: A total of 328 pneumococcal isolates were serotyped by multiplex sequential PCR and/or capsule-quellung reaction. The minimum inhibitory concentrations for 11 antimi- crobial agents were determined by broth microdilution method.  Results: Among 328 strains, 19F (36.3%), 19A (13.4%), 6A (11.9%), 23F (11.0%), 14 (5.8%), 6B (5.2%), and 15B/C (4.3%) were the most common serotypes. The coverage rates of 7-, 10-, and 13-valent conjugate vaccines (PCV7, PCV10, and PCV13) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Serotype; Antimicrobial resistance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200141

Serum ascorbic acid concentration in patients with acute Falciparum malaria infection: possible significance
Provedor de dados: 55
Autores: Hassan,Garba Ibrahim; Gregory,Ubom; Maryam,Haruna.
Falciparum malaria infection is associated with significant destruction of erythrocytes. This leads to the release of toxic metabolic products, including oxidant compounds.We measured the serum concentration of the antioxidant, ascorbic acid, in 129 patients presenting with acute falciparum malaria infection and in 65 healthy individuals. None of the study subjects administered any form of ascorbic acid supplementation within one week prior to participation in this study. The mean serum ascorbate concentration in infected adult males (n = 49, age range 18-50 years) was found to be 2.02 ± 0.20 mg/dL, and it was 2.03 ± 0.24 mg/dL in infected adult females (n = 56, age range 18-50 years). These values were significantly greater than the serum ascorbate levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Ascorbate; Antioxidant.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500007

Serum levels of immunoglobulin free light chains in patients with chronic hepatitis C presenting cryoglobulinemia
Provedor de dados: 55
Autores: Oliveira,Isabela S.; Cabral,Milena S.; Jesus,Larissa S.; Paraná,Raymundo; Atta,Ajax M.; Atta,Maria Luiza B. Sousa.
Hepatitis C virus (HCV) infects B-lymphocytes, provokes cellular dysfunction and causes lymphoproliferative diseases such as cryoglobulinemia and non-Hodgkin's B-cell lymphoma. In the present study, we investigated the serum levels of kappa and lambda free light chains (FLC) of immunoglobulins and the kappa/lambda FLC ratio in Brazilian patients with chronic HCV infection and cryoglobulinemia. We also analyzed the immunochemical composition of the cryoglobulins in these patients. Twenty-eight cryoglobulinemic HCV patients composed the target group, while 37 HCV patients without cryoglobulinemia were included as controls. The median levels of kappa and lambda FLC were higher in patients with cryoglobulinemia compared to controls (p = 0.001 and p = 0.003,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Cryoglobulin; Free light chain; B-cell polyclonal activation.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600638

Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
Provedor de dados: 55
Autores: Cordeiro,Cynthia Azeredo; Vieira,Erica Leandro Marciano; Rocha,Natália Pessoa; Castro,Vinicius Monteiro; Oréfice,Juliana Lambert; Barichello,Tatiana; Costa,Rogerio Alves; Oréfice,Fernando; Young,Lucy; Teixeira,Antonio Lucio.
Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment.  Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.  Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200176

Serum levels of vancomycin: is there a prediction using doses in mg/kg/day or m2/day for neonates?
Provedor de dados: 55
Autores: Romanelli,Roberta Maia de Castro; Anchieta,Lêni Márcia; Fernandes,Juliana Chaves Abreu; Lima,Mariana Antunes Faria; Souza,Taís Marina de; Rosado,Viviane; Clemente,Wanessa Trindade; Camargos,Paulo Augusto Moreira.
Abstract Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin; Drug dosage calculations; Pharmacokinetics; Infant; Newborn; Sepsis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500451

Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients
Provedor de dados: 55
Autores: Passos,Ana Isabela Morsch; Dertkigil,Rachel Polo; Ramos,Marcelo de Carvalho; Busso-Lopes,Ariane Fidelis; Tararan,Cibele; Ribeiro,Erivan Olinda; Schreiber,Angélica Zaninelli; Trabasso,Plinio; Resende,Mariangela Ribeiro; Moretti,Maria Luiza.
ABSTRACT  Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy.  Materials and methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients’ serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. The association among the variables was analyzed by univariate and multivariate regression analysis.  Results: 60 patients were included in the study. The patients were classified in three groups: Pneumocystis jirovecii pneumonia (19 patients), community-acquired pneumonia (18...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary infection; HIV/AIDS; (1-3)-β-D-Glugan; LDH; LAMP; Pneumocystosis; Fungal infection.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600606

Seven years of experience with zygomycosis in Iran: a seasonal disease
Provedor de dados: 55
Autores: Mirzaie,Ali Zare; Akram,Jahangiri; Sadeghipour,Alireza; Shayanfar,Nasrin.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500020

Severe disseminated tuberculosis in a 4-year-old girl
Provedor de dados: 55
Autores: Rey,Luis Carlos; Sousa,Anastacio Queiroz.
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600016

Severe infective endocarditis with systemic embolism due to community associated methicillin-resistant Staphylococcus aureusST630
Provedor de dados: 55
Autores: Zheng,Beiwen; Jiang,Saiping; Xu,Zemin; Xiao,Yonghong; Li,Lanjuan.
Community-associated methicillin-resistant Staphylococcus aureus(CA-MRSA) are increasingly causing infective endocarditis over the past decade. Here we report a healthy man who developed a severe acute infective endocarditis with systemic embolism caused by CA- MRSA. The strain was recovered from repeated blood cultures and was characterized using molecular detection and genotyping. The S. aureusisolate was typed as ST630 SCCmecV with spa-type t4549, agrI/IV and was PVL-negative. This is the only case report, to our knowledge, of CA-MRSA infective endocarditis in China. This case highlights the emergence and geographical spread of life-threatening CA-MRSA infection within China.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Community-acquired MRSA Infective endocarditis; ST 630; Surgical therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100085

Severe low back pain due to retroperitoneal abscess formation in diabetic patients
Provedor de dados: 55
Autores: Ohmori,Masami; Kobayashi,Eiji; Harada,Kazuhiro; Sugimoto,Koh-ichi; Ohkami,Hitoshi; Tsutsumi,Haruhiko; Fujimura,Akio.
We report two cases of diabetic patients with severe low back pain associated with retroperitoneal abscesses. In the first case, multiple retroperitoneal and spinal epidural abscesses were detected. Paraplegia due to the spinal epidural abscess was not relieved by drainage of the abscess and subsequent antibiotic therapy. In the second case, drainage of the retroperitoneal abscess and antibiotics were immediately started, resulting in successful recovery. Thus, we suggest that if a diabetic patient complains of low back pain, potential abscess formations should be considered and given appropriate treatment before administering epidural anesthetic injections for pain relief.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Low back pain; Retroperitoneal abscess; Paraplegia; Diabetes mellitus.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600007

Severe metabolic acidosis and Fanconi syndrome during stavudine and abacavir therapy in a resource-limited setting
Provedor de dados: 55
Autores: Bansie,Rakesh D.; Vreden,Stephen G.S.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600025

Severe shoulder tendinopathy associated with levofloxacin
Provedor de dados: 55
Autores: Eyer-Silva,Walter de Araujo; Pinto Netto,Henrique de Barros; Pinto,Jorge Francisco da Cunha; Ferry,Fernando Raphael de Almeida; Neves-Motta,Rogério.
Fluoroquinolone (FQ)-associated tendinopathy and myopathy are uncommon but well recognized complications of the use of this class of antibacterial agents. The case of a 63-year-old previously asymptomatic female patient who developed severe left shoulder tendinopathy after surreptitiously doubling the prescribed dose of levofloxacin for the treatment of community-acquired pneumonia is reported here. Surgical stabilization with suture anchors and subacromial decompression were needed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fluoroquinolone; Levofloxacin; Tendinitis; Tendinopathy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400016

Severe vasculonecrotic erythema nodosum leprosum following thalidomide withdrawal without tapering doses: do we have something unusual?
Provedor de dados: 55
Autores: Mahajan,Vikram K; Chauhan,Pshpinder S; Sharma,Nand Lal; Sharma,Anju L; Mehta,Karaninder S.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100018

Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance
Provedor de dados: 55
Autores: Rocha,Jaime L.; Tuon,Felipe Francisco; Johnson,James R.
BACKGROUND: Optimal empirical therapy of urinary tract infection requires accurate knowledge of local susceptibility patterns, which may vary with organism and patient characteristics. METHODS: Among 9,798 consecutive, non-duplicate, community-source urine isolates from ambulatory patients &gt; 13 years old, from clinical laboratory and an academic medical center in Curitiba, Brazil (May 1st to December 1st, 2009), susceptibility data for ampicillin, nitrofurantoin, trimethoprim-sulfamethoxazole, gentamicin, fluoroquinolones, and ceftriaxone/cefotaxime were compared with organism and patient gender and age. RESULTS: The female-to-male ratio decreased with age, from 28.1 (among 20-29 year-olds) to 3.3 (among &gt; 80 year-olds). Overall, susceptibility...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urinary tract infections; Anti-bacterial agents; Drug resistance bacterial; Fluoroquinolones; Escherichia coli.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200002

Sexual behavior and sexually transmitted diseases in street-based female sex workers in Rajshahi City, Bangladesh
Provedor de dados: 55
Autores: Mondal,Nazrul Islam; Hossain,Kamal; Islam,Rafiqul; Mian,Abul Bashar.
We analyzed the sexual behavior and sexually transmitted diseases (STDs) of street-based female sex workers (SFSWs) of Rajshahi city and examined their socio-demographic profiles. Among the SFSWs attending three drop-in centers (DIC) named PIACT, PROVA, and Suraksha Madhumita in Rajshahi, 150 self-motivated and willing individuals were interviewed through a structured questionnaire to obtain obstetric histories and socio-demographic information. Among these SFSWs, 56.7% were infected with two or more pathogens of STDs, with gonorrhea, chlamydia, herpes, syphilis, and trichomoniasis observed in 23.3, 27.3, 24.0, 17.3, and 20.0%, respectively. We found a strong association between the prevalence of STDs among SFSWs and their socio-demographic profiles....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexual behaviors; HIV/AIDS; STDs; SFSWs; Bangladesh.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400006

Sexual transmission of HCV
Provedor de dados: 55
Autores: Prado,Kleber Dias do.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700003

Sexually transmitted diseases among psychiatric patients in Brazil
Provedor de dados: 55
Autores: Dutra,Maria Rita Teixeira; Campos,Lorenza Nogueira; Guimarães,Mark Drew Crosland.
Sexually transmitted diseases are still highly prevalent worldwide and represent an important public health problem. Psychiatric patients are at increased risk of sexually transmitted diseases but there are scarce published studies with representative data of this population. We sought to estimate the prevalence and correlates of self-reported sexually transmitted diseases among patients with mental illnesses under care in a national representative sample in Brazil (n = 2145). More than one quarter of the sample (25.8%) reported a lifetime history of sexually transmitted disease. Multivariate analyses showed that patients with a lifetime sexually transmitted disease history were older, had history of homelessness, used more alcohol and illicit drugs,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Psychiatric patients; Sexually transmitted infections; Brazil.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100013

Sexually-transmitted viral diseases in women: clinical and epidemiological aspects and advances in laboratory diagnosis
Provedor de dados: 55
Autores: Pinto,Álvaro Piazzetta; Baggio,Hugo César Cardoso; Guedes,Guilherme Barroso.
Sexually transmitted diseases (STDs) have long been known, but they have only recently been recognized as causes of significant long-term morbidity, mainly as a result of increased knowledge concerning viral STDs. The relationship of these diseases with conditions such as anogenital cancer and acquired immunodeficiency syndrome (AIDS) has made viral STDs an important issue in the healthcare of women and infants, and in reproductive health. The evolution of the AIDS pandemic is now characterized by growing differences between rich and poor nations. New diagnostic tools include rapid tests of blood, urine and saliva samples. New techniques, such as computerized cytology, have been developed for the diagnosis of human papillomavirus (HPV). Women infected with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually-transmitted diseases; Viral HIV human papillomavirus herpes simplex virus.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300007

Shewanella putrefaciens infective endocarditis
Provedor de dados: 55
Autores: Constant,Jonathan; Chernev,Ivan; Gomez,Eric.
Shewanella putrefaciens rarely causes infection in humans. In the last few decades a growing number of cases have been described. The following report outlines the case of a 40-year- old immunocompetent white man with S. putrefaciens infective endocarditis. This is the first known case of infective endocarditis due to an apparently monomicrobial S. putrefaciens infection, and the second known case of S. putrefaciens-related infective endocarditis worldwide.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Shewanella; Endocarditis; Bacteremia.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600686

Short-interfering RNAs as antivirals against rabies
Provedor de dados: 55
Autores: Brandão,Paulo Eduardo; Castilho,Juliana Galera; Fahl,Willian; Carnieli Jr.,Pedro; Oliveira,Rafael de Novaes; Macedo,Carla Isabel; Carrieri,Maria Luiza; Kotait,Ivanete.
This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SiRNA; Rabies; Antiviral.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011

Should tenofovir ever be used in association with didanosine?
Provedor de dados: 55
Autores: Diaz,Ricardo Sobhie.
Tipo: Info:eu-repo/semantics/other
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600001

Signal to cut-off (S/CO) ratio and detection of HCV genotype 1 by real-time PCR one-step method: is there any direct relationship?
Provedor de dados: 55
Autores: Albertoni,Guilherme; Arnoni,CP; Araújo,PRB; Carvalho,FO; Barreto,JA.
BACKGROUND: Polymerase chain reaction (PCR) methods play an essential role in providing data related to diagnosis, monitoring and treatment of hepatitis C virus (HCV) infection. EIA results are reported as ''reactive'' or ''non reactive'' and EIA S/CO ratio may also be reported as ''high'' or ''low.'' This study aimed to evaluate the performance of a real-time RT-PCR and assess whether there is relationship between S/CO and PCR results. STUDY DESIGN AND METHODS: Sera from blood donors were analyzed by Enzyme-Linked Immunosorbent Assay (ELISA) and RT-PCR assay to detect HCV infection. RESULTS: The RT-PCR assay to genotypes 1a/b showed an acceptable linear response in serial dilutions. The samples were divided into two groups based on their serological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; HCV genotype 1; Real-time PCR; ELISA; RNA extraction.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200006

Signs and symptoms indicative of community-acquired pneumonia in infants under six months
Provedor de dados: 55
Autores: March,Maria de Fátima Bazhuni Pombo; Sant'Anna,Clemax Couto.
OBJECTIVE: Evaluation of the clinical signs and symptoms predicting bacterial and viral pneumonia, in accordance with the Brazilian National Control Program for Acute Respiratory (ARI). METHODS: Observational prospective study. Seventy-six children from birth to six months of age who had pneumonia were studied in the emergency room. The patients were subdivided into two groups, based on radiological findings (gold-standard): 47 had bacterial pneumonia, and 29 had viral pneumonia. The frequencies, sensitivities, and specificities of the signs and symptoms were evaluated. RESULTS: The sensibilities and sensitivities of general findings in bacterial pneumonia were, respectively: fever 53.2%/40.0%; hypoactivity 68.4%/55.6% and prostration detected by the...
Tipo: Info:eu-repo/semantics/article
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200005

Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction
Provedor de dados: 55
Autores: Wang,Yong-Zhong; Xiao,Jun-Hua; Liu,Long-Gen; Ye,Chun-Yan; Shen,Hong-Yu; Xu,Tian-Min; Zhu,Ke-Zhuan.
OBJECTIVES: Detection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (HBV) genotyping are essential for monitoring treatment of HBV infection. We developed a multiplex polymerase chain reaction-ligase detection reaction (PCR-LDR) assay for the rapid detection of HBV genotypes and mutations associated with lamivudine, adefovir, and telbivudine resistance in HBV-infected patients. METHODS: HBV templates were amplified by PCR, followed by LDR and electrophoresis on a sequencer. The assay was evaluated using plasmids that contained wild-type or mutant HBV sequences and 216 clinical samples. RESULTS: The PCR-LDR assay and sequencing gave comparable results for 158 of the 216 samples (73.1%) with respect to mutation detection and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Drug resistance; Mutation; Genotype.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600010

Simultaneous viral infection and childhood bronchiolitis obliterans
Provedor de dados: 55
Autores: Hirschheimer,Mário; Silva,Paulo S. L.; Giudici,Roseli; Carrilho,Milene; Mauad,Thais; Ishida,Maria.
Lower respiratory tract infections by respiratory syncytial virus (RSV) are frequent in childhood. Association of RSV with bronchiolitis obliterans has rarely been established. We report a 13-month-old child with bronchiolitis obliterans following co-infection by RSV and adenovirus, and suggest that complicated evolution of an acute bronchiolitis case can indicate an association of pathogens.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute bronchiolitis; Adenovirus; Bronchiolitis obliterans; Co-infection; Lower respiratory tract infections; Respiratory syncytial virus.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300009

Simvastatin inhibits planktonic cells and biofilms ofCandida and Cryptococcusspecies
Provedor de dados: 55
Autores: Brilhante,Raimunda Sâmia Nogueira; Caetano,Erica Pacheco; Oliveira,Jonathas Sales de; Castelo-Branco,Débora de Souza Collares Maia; Souza,Elizabeth Ribeiro Yokobatake; Alencar,Lucas Pereira de; Cordeiro,Rossana de Aguiar; Bandeira,Tereza de Jesus Pinheiro Gomes; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha.
ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candida; Cryptococcus; Simvastatin; Antifungal activity; Biofilm.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459

Sixth case of infective endocarditis caused by Gemella bergeri
Provedor de dados: 55
Autores: Virgilio,Edoardo; Chieco,Paola Addario.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400467

Skin rash, dyspnea and bone pain: secondary syphilis
Provedor de dados: 55
Autores: Manríquez,Juan; Andino-Navarrete,Romina; Andrighetti,Catalina.
Tipo: Info:eu-repo/semantics/article
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100096

Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers
Provedor de dados: 55
Autores: Andrade,Luis Jesuino de Oliveira; Melo,Paulo Roberto Santana de; Atta,Ajax Mercês; Atta,Maria Luiza Brito de Sousa; Jesus,Larissa Santana de; Sousa,Gabriel Menezes de; Silva,Carolina Alves Costa; Paraná,Raymundo.
Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Muscle; Smooth; Antibody specificity; Cryoglobulins; Liver diseases.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100012

Snow's case revisited: new tool in geographic profiling of epidemiology
Provedor de dados: 55
Autores: Papini,Alessio; Santosuosso,Ugo.
Abstract Geographic Profiling technique is used to find the origin of a series of crimes. The method was recently extended to other fields. One of the best renowned data in epidemiology is that by John Snow during an outburst of cholera in London. We wrote Python scripts to perform the analyses to apply the Geographic Profiling for individuating the starting origin of an infection by using the old Snow's data set. We modified the method by applying a weight to each point of the map where cases of cholera were reported. The weight was proportional to the number of cases in a given location.This modification of the Geographic Profiling method allowed to individuate in the map an area of maximum probability of the infection source, which was a few meters wide...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Geographic profiling; Geographic epidemiology; Cholera; John Snow.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100112

Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C
Provedor de dados: 55
Autores: Moura,Alexandre Sampaio; Carmo,Ricardo Andrade; Teixeira,Antonio Lucio; Rocha,Manoel Otávio da Costa.
Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Chemokines; Tumor necrosis factor receptor; Interferon-alpha; Liver fibrosis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013

Spatial exploration of Streptococcus pneumoniae clonal clustering in São Paulo, Brazil
Provedor de dados: 55
Autores: Mouro,Amilton; Kiffer,Carlos; Koga,Paula C.M; Monteiro,Antonio M.V; Camargo,Eduardo Celso Gerbi; Pignatari,Antonio Carlos Campos.
OBJECTIVES: To examine the spatial distribution of Streptococcus pneumoniae and its clonal patterns collected between 2002 and 2006 in São Paulo, Brazil. METHODS: As part of an observational study in São Paulo city, Brazil, S. pneumoniae isolates routinely cultured from blood, respiratory specimens, or cerebrospinal and other profound fluids were selected. Additionally, only isolates with either penicillin (PEN) intermediate (I) or resistant (R) status on routine antibiogram were included, in order to obtain a higher probability of clonal isolates. A single I/R S. pneumoniae isolate per patient was included and submitted to genotypic determination by pulsed field gel electrophoresis (PFGE). Minimum inhibitory concentrations (MICs) were determined for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae penicillin resistance drug resistance; Bacterial molecular epidemiology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500008

Species determination of Brazilian mammals implicated in the epidemiology of rabies based on the control region of mitochondrial DNA
Provedor de dados: 55
Autores: Carnieli Junior,Pedro; Fahl,Willian de Oliveira; Castilho,Juliana Galera; Brandão,Paulo Eduardo; Carrieri,Maria Luiza; Kotait,Ivanete.
Identification of animals that are decomposing or have been run over or burnt and cannot be visually identified is a problem in the surveillance and control of infectious diseases. Many of these animals are wild and represent a valuable source of information for epidemiologic research as they may be carriers of an infectious agent. This article discusses the results obtained using a method for identifying mammals genetically by sequencing their mitochondrial DNA control region. Fourteen species were analyzed and identified. These included the main reservoirs and transmitters of rabies virus, namely, canids, chiroptera and primates. The results prove that this method of genetic identification is both efficient and simple and that it can be used in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mitochondrial DNA; Sequencing; Identification; Mammals; Rabies.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600002

Spectrum and potency of ceftaroline against leading pathogens causing community-acquired respiratory tract and skin and soft tissue infections in Latin America, 2010
Provedor de dados: 55
Autores: Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.
Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with in vitro bactericidal activity against Gram-positive organisms, including methicillinsusceptible and -resistant Staphylococcus aureus, β-haemolytic and viridans group streptococci, and Streptococcus pneumoniae, as well as common Gram-negative organisms. In this study a total of 986 isolates collected in 2010 from patients in 15 medical centers in five Latin American countries from the Assessing Worldwide Antimicrobial Resistance Evaluation Program were identified as community-acquired respiratory tract or skin and soft tissue infection pathogens. Ceftaroline was the most potent agent tested against S. pneumoniae with a MIC90 value (0.12 µg/mL) that was eight-fold...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftaroline; AWARE; S. aureus; S. pneumoniae.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500009

Spinal epidural abscess due to Mycobacterium tuberculosis in a patient with AIDS: case report and review of the literature
Provedor de dados: 55
Autores: Metta,Humberto; Corti,Marcelo; Redini,Liliana; Yampolsky,Claudio; Schtirbu,Ricardo.
Spinal epidural abscess (SEA) is a rare infectious disorder that often has delayed diagnosis and is associated with significant morbidity and mortality rates. We present a case of an AIDS patient with a SEA due to Mycobacterium tuberculosis. This type of SEA in AIDS patients is characterized by localized spinal pain and prolonged fever. Magnetic resonance imaging is the method of choice in the diagnostic process. Early diagnosis, followed by specific therapy (surgical decompression combined with antituberculous drugs), is necessary to improve the prognosis of these kinds of patients.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Spinal epidural abscess; Mycobacterium tuberculosis; AIDS.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200013

Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis
Provedor de dados: 55
Autores: Fanpu,Ji; Zhang,Shu; Huang,Na; Deng,Hong; Li,Zongfang.
Patients with hepatitis C virus-related decompensated cirrhosis can benefit frominterferonbased antiviral therapy, but the common complication of cytopenia is a contraindication for this treatment. Splenectomy prior to interferon therapy may alleviate this problem. To investigate whether splenectomy improves the efficacy of antiviral therapy, 13 interferonnaïve hepatitis C virus decompensated cirrhotic patients underwent splenectomy between January 2008 and January 2011, followed 1-3 months later by an interferon-based therapeutic regimen (pegylated/standard interferon-α combined with ribavirin for 48 weeks). Ten (76.9%) of the patients developed postoperative complications, which included minor portal vein thrombosis (2/13, 15.4%) and transient ascites...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C virus; Thrombocytopenia; Splenectomy; Antiviral therapy.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500014

Spondylodiscitis and endocarditis caused by S. vestibularis
Provedor de dados: 55
Autores: Tufan,Muge Aydin; Hamide,Kart-Koseoglu; Duygu,Ersozlu-Bozkirli; Ozlem,Azap; Kadir,Tufan; Eftal,Yucel Ahmet.
Streptococcus vestibularis is a recently described member of the viridans group that was first isolated from the vestibular mucosa of the human oral cavity and described as a new species in 1988. It has been rarely associated with human infections. In few papers, it has been reported as a causal agent of systemic infection in immunosupressed adults and in those with other severe underlying diseases, like coronary valve diseases. A 65-year-old woman was admitted to the hospital with complaints of fever for three months, general malaise, effort dyspnea, weight loss, back pain and myalgia. Both native aortic valve endocarditis and spondylodiscitis due to Streptococcus vestibularis were detected. The patient was successfully treated with intravenous potassium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Endocarditis; Spondylodiscitis; Streptococcus vestibularis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400012

Spondylodiscitis and infectious endocarditis: a round-trip to be considered
Provedor de dados: 55
Autores: Calderaro,Daniela; Gualandro,Danielle Menosi; Yu,Pai Ching; Marques,Andre Coelho; Puig,Luiz Boro; Caramelli,Bruno.
The association between spondylodiscitis and endocarditis was first reported in 1965 by de Sèze et al. The most common clinical picture of this association is musculoskeletal symptoms preceding endocarditis diagnosis, but we report here a case of spondylodiscitis complicating endocarditis in its late course. A 70-year-old man, with an established diagnosis of mitral valve endocarditis caused by Streptococcus intermedius, early submitted to surgical treatment because of heart failure, who had an uneventful recovery up to the 12th day of antibiotic therapy when he presented intensive backache, with tenderness in the two lower lumbar vertebras. Spondylodiscitis was confirmed by a magnetic resonance imaging and the treatment was non-esteroidal anti-inflamatory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Endocarditis; Discitis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600021

Spondylodiscitis associated with recurrent Serratia bacteremia due to a transjugular intrahepatic portosystemic shunt (TIPS): a case report
Provedor de dados: 55
Autores: Marques,Nuno; Sá,Rosa; Coelho,Filomena; Cunha,Saraiva da; Meliço-Silvestre,A.
We report a case of spondylodiscitis caused by multiresistant Serratia marcescens in a cirrhotic patient who had several Serratia bacteremias after the placement of a transjugular intrahepatic portosystemic shunt (TIPS) device. We concluded that an endovascular stent that can not be removed makes management of recurrent bacteremia difficult. Furthermore, back pain due to bacteremia is indicative of spondylodiscitis. Serratia marcescens can be an aggressive pathogen, causing spinal infection.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Serratia marcescens; Recurrent bacteremia; Spondylodiscitis; TIPS.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500016

Spontaneous bacterial peritonitis caused by Streptococcus bovis: case report and review of the literature
Provedor de dados: 55
Autores: Hörner,Rosmari; Salla,Adenilde; Oliveira,Loiva Otonelli de; Forno,Nara Lucia Frasson Dal; Righi,Roselene Alves; Domingues,Vanessa Oliveira; Rigatti,Fabiane; Mayer,Letícia Eichstaedt.
Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication that occurs in patient with cirrhosis and ascites. It occurs in 10% to 30% of patients admitted to hospital. The organisms that cause SBP are predominantly enteric. Escherichia coli is the most frequent recovered pathogen, and Gram-positive bacteria, mainly Staphylococcus spp., are being considered an emerging causative agent of SBP. Streptococcus bovis that may be found as part of the commensal bowel flora in about 10% of healthy adults constitute an uncommon cause of peritonitis that was first reported in 1994. We describe the first case of SBP at the University Hospital of Santa Maria (HUSM) caused by S. bovis, resistant to the antibiotics erythromycin and clindamycin...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Peritonitis; Streptococcus bovis; Cirrhosis; Ascites.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300017

Spontaneous inflammatory pelvic disease in adult non-castrated female rats treated with estrogen
Provedor de dados: 55
Autores: Ramos,Aristóteles M G; Perazzio,Sandro; Camargos,Aroldo F. de; Pereira,Fausto E.L.
The adaptive immune response of the genital tract is under the control of sexual steroids; however, the influence of sex hormones on innate immune mechanisms of the genital mucosa are only beginning to be understood. We found that long-term estrogen treatment increases the risk for inflammatory pelvic diseases in adult non-castrated female rats. Female rats (110 g to 130 g) received estrogen (10 rats; 17-beta estradiol, 50 mg pellet; 10 rats: subcutaneous weekly injection of estradiol valerate 0.166 mg/kg). Ten rats received a pellet of 17-beta estradiol and were treated with amoxicillin, 50 mg/kg after the 90th day of exposure to estrogen. Three control groups of ten rats were also used. The estrogen-treated rats developed an inflammatory pelvic disease,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Inflammatory pelvic disease; Estrogen; Mucosal immunity; Rats.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100003

Spontaneous neutrophil activation in HTLV-1 infected patients
Provedor de dados: 55
Autores: Guerreiro,Jaqueline B.; Porto,Maria Aurélia F.; Santos,Silvane B.; Lacerda,Lino; Ho,John L.; Carvalho,Edgar M.
Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and proliferation, but little is known about the innate immune response due to HTLV-1 infection. We evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT) to formazan in HTLV-1 infected subjects and the association between neutrophil activation and IFN-gamma and TNF-alpha levels. Blood was collected from 35 HTLV-1 carriers, from 8 patients with HAM/TSP (HTLV-1- associated myelopathy); 22 healthy individuals were evaluated for spontaneous and lipopolysaccharide (LPS)-stimulated neutrophil activity (reduction of NBT to formazan). The production of IFN-gamma and TNF-alpha by unstimulated mononuclear cells was determined by ELISA. Spontaneous NBT levels,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; IFN-gamma; TNF-alpha; LPS; Neutrophil activation.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600010

Spontaneous pneumomediastinum due to paralytic rabies
Provedor de dados: 55
Autores: Wang,Wuping; Ni,Yunfeng; Gao,Kongxiang; Lu,Qiang; Li,Xiaofei.
Rabies is a fatal disease resulting from rabies virus infection, causing severe neurological symptoms and ultimately death by destroying the nervous system. In general, a patient tends to see a neurologist or an infectious diseases physician, with very common and typical discipline-related signs and symptoms, such as hydrophobia, aerophobia, and mental disorders. However, we reported a rabies patient who was first admitted to see a thoracic surgeon with spontaneous pneumomediastinum.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Rabies; Spontaneous pneumomediastinum.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100016

Spontaneous pneumothorax: a fatal complication in HIV-infected patients
Provedor de dados: 55
Autores: Safe,Izabella Picinin; Oliveira,Victor Costa Morais de; Marinho,Paula Marques; Lacerda,Marcus Vinicius; Damian,Márcia Melo.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400466

Spontaneous splenic rupture due to dengue fever: report of two cases
Provedor de dados: 55
Autores: Seravali,Maria Roberta Meneguetti; Santos,Antônio Henrique Gomes dos; Costa,Carlos Eduardo Fávero; Rangel,Diego Teixeira Alves; Valentim,Leonardo Fernandes; Gonçalves,Raphael Moreira.
Dengue is a febrile illness caused by Flavivírus and mainly transmitted by the mosquito Aedes aegypiti which have been a serious epidemic in Rio de Janeiro. In most of cases it was a self limited disease. We report two cases of a serious and rare complication of this viral infection.
Tipo: Info:eu-repo/semantics/article
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600019

Sporadic human cutaneous anthrax outbreak in Shaanxi Province, China: report of two cases from 2018
Provedor de dados: 55
Autores: Liu,Yuanyuan; Li,Yongqin; Wang,Qiaoxia; Fu,Jianjun; Ji,Fanpu.
ABSTRACT China’s compulsory annual livestock anthrax vaccination policy has remarkably reduced but not completely eradicated human anthrax infections. Herein we describe a sporadic human cutaneous anthrax outbreak involving two cases in 2018 in Shaanxi Province, both involving herdsman who dealt with unvaccinated and potentially sick cattle. Both patients showed Bacillus anthracis-positive blister smear and blood culture. Treatment with penicillin was followed by uneventful recovery for both. The prompt performance of the prophylactic measures successfully interrupted the further transmission of this sporadic human cutaneous anthrax outbreak.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bacillus anthracis; Cutaneous anthrax; Vaccination.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100081

Spread of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clones in patients with ventilator-associated pneumonia in an adult intensive care unit at a university hospital
Provedor de dados: 55
Autores: Royer,Sabrina; Faria,Ana Luiza Souza; Seki,Liliane Miyuki; Chagas,Thiago Pavoni Gomes; Campos,Paola Amaral de; Batistão,Deivid William da Fonseca; Asensi,Marise Dutra; Gontijo Filho,Paulo P.; Ribas,Rosineide Marques.
Background:In Brazil, ventilator-associated pneumonia (VAP) caused by carbapenem resis- tant Acinetobacter baumanniiand Pseudomonas aeruginosaisolates are associated with signiﬁcant mortality, morbidity and costs. Studies on the clonal relatedness of these isolates could lay the foundation for effective infection prevention and control programs.Objectives: We sought to study the epidemiological and molecular characteristics of A. baumannii vs. P. aeruginosaVAP in an adult intensive care unit (ICU).Methods: It was conducted a cohort study of patients with VAP caused by carbapenem resistant A. baumanniiand P'. aeruginosaduring 14 months in an adult ICU. Genomic studies were used to investigate the clonal relatedness of carbapenem resistant OXA-23-producing...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Intensive care unit; Molecular epidemiology; Multidrug-resistant.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400350

Standardization of first and second-line antitubercular susceptibility testing using BacT Alert 3D system: a report from a tertiary care centre in India
Provedor de dados: 55
Autores: Nair,Deepthi; Capoor,Malini R.; Rawat,Deepti; Srivastava,Lakshmi; Aggarwal,Pushpa.
Resurgence of multidrug resistant tuberculosis has lead to demand for rapid susceptibility testing. Conventional methods take &gt; 3 weeks and are tedious. Automated methods have superseded them for first line drug susceptibility testing. An attempt was made to standardize first and second line susceptibility testing using the BacT Alert 3D system (Biomerieux). And compare results with Lowenstein Jensen's (LJ) method. 121 isolates of Mycobacterium tuberculosis, 67 pulmonary and 54 extra pulmonary were subjected to sensitivity to first and second line drugs. Multidrug resistance was detected equally by both methods at 15.7%. 100% agreement was observed between the two methods for aminoglycosides, rifampicin, ethionamide and ciprofloxacin. 91.5% agreement...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antitubercular sensitivity; Second line; BacT Alert 3D system; LJ proportion.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600007

Staphylococcal scalded skin syndrome in an adult, immunocompetent patient
Provedor de dados: 55
Autores: Koufakis,Theocharis; Gabranis,Ioannis; Karanikas,Konstantinos.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200228

Staphylococcus aureus bacteremia: comparison of two periods and a predictive model of mortality
Provedor de dados: 55
Autores: Conterno,Lucieni de Oliveira; Wey,Sérgio Barsanti; Castelo,Adauto.
Staphylococcus aureus is an important pathogen causing bacteremia, primarily affecting hospitalized patients. We studied the epidemiology of S. aureus bacteremia, comparing two periods (early and mid 1990s) and developed a predictive model of mortality. A nested case-control was done. All 251 patients over 14 years old with positive blood cultures for S. aureus were selected. MRSA (methicillin resistant S. aureus) was isolated in 63% of the cases. When comparing the two periods MRSA community-acquired bacteremia increased from 4% to 16% (p=0.01). There was no significant difference in the mortality rate between the two periods (39% and 33%, p=0.40). Intravascular catheters provoked 24% of the cases of bacteremia and were associated with the lowest rate of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Bacteremia; Mortality.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000600004

Staphylococcus aureus bacteremia: what is the impact of oxacillin resistance on mortality?
Provedor de dados: 55
Autores: Cassettari,V.C.; Strabelli,T.; Medeiros,E.A.S.
In order to analyse the impact of oxacillin resistance on the mortality of Staphylococcus aureus bacteremia, and to assess the antimicrobial susceptibility of community-acquired strains in two large university hospitals (the Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and the Instituto Central do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), we carried out a four-month-long prospective cohort study, which included 163 consecutive cases of S. aureus bacteremia. Of these, 140 (85.9%) were hospital-acquired, 9 (5.5%) were community-acquired and 14 (8.6%) were of indeterminate origin. No cases of community-acquired infection by oxacillin-resistant S. aureus was identified....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Bacteremia; Mortality.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100012

Staphylococcus aureus in tonsils of patients with recurrent tonsillitis: prevalence, susceptibility profile, and genotypic characterization
Provedor de dados: 55
Autores: Cavalcanti,Veraluce Paolini; Camargo,Leandro Azevedo de; Moura,Fabiano Santana; Melo Fernandes,Edson Júnior de; Lamaro-Cardoso,Juliana; Braga,Carla Afonso da Silva Bitencourt; André,Maria Cláudia Porfirio.
ABSTRACT  Introduction: Bacterial tonsillitis is an upper respiratory tract infection that occurs primarily in children and adolescents. Staphylococcus aureus is one of the most frequent pathogens in the etiology of tonsillitis and its relevance is due to its antimicrobial resistance and persistence in the internal tissues of the tonsils. Tonsillectomy is indicated in cases of recurrent tonsillitis after several failures of antibiotic therapy.  Material and methods: In this study we evaluated 123 surgically removed tonsils from patients who had history of recurrent tonsillitis. The tonsils were submitted to microbiological analysis for detection of S. aureus. The isolates were identified by PCR for femA gene. Antimicrobial susceptibility of the isolates...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tonsillitis; Tonsillectomy; Staphylococcus aureus; Pulsed field gel electrophoresis.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100008

Staphylococcus aureus nasal carriage among health care workers in a Nepal Hospital
Provedor de dados: 55
Autores: Shrestha,Bidya; Pokhrel,Bharat Mani; Mohapatra,Tribhuban M.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500001

Staphylococcus aureus nasal carriage among outpatients attending primary health care centers: a comparative study of two cities in Saudi Arabia and Egypt
Provedor de dados: 55
Autores: Shady,Hala M. Abou; Bakr,Alaa Eldin A.; Hashad,Mahmoud E.; Alzohairy,Mohammad A.
Epidemiological and molecular data on community acquired methicillin resistant Staphylococcus aureus(CA-MRSA) are still scarce in both Egypt and Saudi Arabia. There is almost no data regarding methicillin resistant Staphylococcus aureus (MRSA) prevalence in both countries. This study was conducted to investigate the prevalence and molecular epidemiology of S. aureusand MRSA nasal carriage among outpatients attending primary health care centers in two big cities in both countries. A total of 206 nasal swabs were obtained, 103 swabs from each country. S. aureusisolates were characterized by antibiotic susceptibility, presence of mecAand PVL genes, SCCmec-typing and spa typing, the corresponding Multi locus sequence typing clonal complex was assigned for each...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Community acquired methicillin resistant Staphylococcus aureus(CA-MRSA); Outpatients in Egypt and Saudi; Arabia; SCCmec typing; Spa typing.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100068

Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts
Provedor de dados: 55
Autores: Ning,Rende; Zhang,Xianlong; Guo,Xiaokui; Li,Qingtian.
OBJECTIVE: Activation of nuclear factor kappaB by diverse bacteria regulates the secretion of chemokines and cytokines. Staphylococcus aureus (S. aureus)-infected osteoblasts can significantly increase the secretion of interleukin-6 and monocyte chemoattractant protein-1. The aim of this study was to investigate whether S. aureus can activate nuclear factor kappaB in human osteoblasts, and whether the activation of nuclear factor kappaB by S. aureus regulates the secretion of interleukin-6 and monocyte chemoattractant protein-1. METHODS: Immunoblot and electrophoretic mobility shift assay were used to detect the degradation of IκBa and activation of nuclear factor kappaB in human osteoblasts in response to S. aureus, respectively. Enzyme-linked...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Osteoblasts; NF-kappaB; Interleukin-6; Chemokine CCL2.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300001

Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
Provedor de dados: 55
Autores: Vidal,Jose E.; Oliveira,Augusto C. Penalva de; Dauar,Rafi F.; Boulware,David R.
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcal meningitis; Cryptococccosis; Epidemiology; Diagnosis; Treatment; Mortality; Latin America.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008

Streptococcus bovis endocarditis: analysis of cases between 2005 and 2014
Provedor de dados: 55
Autores: Mello,Renato; Santos,Marisa da Silva; Golebiosvki,Wilma; Weksler,Clara; Lamas,Cristiane.
Background: Streptococcus bovis is a classical etiology of endocarditis and is associated with colonic lesions. No series of cases from Brazil has been described.  Objectives: To describe aspects of S. bovis endocarditis.  Methods: This is a case series of patients admitted to a cardiac surgery referral center, during the years 2005-2014. Clinical, laboratory, echochardiographic, colonoscopic, treatment, surgical and outcome variables were studied.  Results: Nine patients with S. bovis endocarditis were included; all cases fulﬁlled the modiﬁed Duke criteria. Incidence was 8/220 (4%) in years 2006-2014. There were seven male and two female patients; mean age was 56.7 years, standard deviation 13.4. All patients had native aortic valve involvement....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Infective endocarditis; Streptococcus bovis group; Cardiac surgery; Colonic lesions.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200209

Streptococcus pyogenes meningitis in children: report of two cases and literature review
Provedor de dados: 55
Autores: Arnoni,Mariana V.; Berezin,Eitan N.; Sáfadi,Marco A.P.; Almeida,Flávia J.; Lopes,Cláudia R.C.
Streptococcus pyogenes meningitis (SPM) occurs sporadically, even with the increase of invasive streptococcal disease observed in the past years. We reported two cases of SPM in infants to alert pediatricians for the possibility of this agent as a cause of meningitis in previously healthy children.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pyogenes; Meningitis; Children.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300015

Strong correlation by ultrasonography of hepatomegaly and the presence of co-infection in HIV/HCV cirrhotic patients
Provedor de dados: 55
Autores: Vezozzo,Denise Cerqueira Paranaguá; Mendes-Correa,Maria Cassia; Cunha-Silva,Marlone; Alvarado-Mora,Mónica Viviana; França,João Ítalo Dias; Sebba,José Luiz; Nicodemo,Antonio Carlos; Oliveira,Claudia P.M.S.; Carrilho,Flair José.
OBJECTIVES: Progression of hepatic fibrosis is accelerated in patients co-infected with human immunodeficiency virus and hepatitis C virus compared to hepatitis C virus mono-infected patients. This study aimed to compare ultrasound features and selected clinical and biochemical variables between patients with human immunodeficiency virus/hepatitis C virus co-infection (n = 16) versus hepatitis C virus mono-infection (n = 16). METHODS: Each patient underwent abdominal ultrasound, and a specific evaluation was performed in order to detect findings consistent with chronic liver disease. Characterization of spleen size, liver structural pattern, diameter of the portal, spleen, and mesenteric veins was based on classical ultrasound parameters. Propensity score...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ultrasonography; HIV/HCV co-infection; Hepatomegaly; Liver size; Cirrhosis.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200006

Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein
Provedor de dados: 55
Autores: Santos-López,Gerardo; Scior,Thomas; Borraz-Argüello,María del Tránsito; Vallejo-Ruiz,Verónica; Herrera-Camacho,Irma; Tapia-Ramírez,José; Reyes-Leyva,Julio.
A point mutation from guanine (G) to adenine (A) at nucleotide position 1081 in the hemagglutinin-neuraminidase (HN) gene has been associated with neurovirulence of Urabe AM9 mumps virus vaccine. This mutation corresponds to a glutamic acid (E) to lysine (K) change at position 335 in the HN glycoprotein. We have experimentally demonstrated that two variants of Urabe AM9 strain (HN-A1081 and HN-G1081) differ in neurotropism, sialic acidbinding affinity and neuraminidase activity. In the present study, we performed a structure-function analysis of that amino acid substitution; the structures of HN protein of both Urabe AM9 strain variants were predicted. Based on our analysis, the E/K mutation changes the protein surface properties and to a lesser extent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemagglutinin-neuraminidasa; Mumps virus; Paramyxovirus; 3D structure prediction; Sialic acid.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100007

Study of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infections
Provedor de dados: 55
Autores: Stehling,Eliana Guedes; Silveira,Wanderley Dias da; Leite,Domingos da Silva.
A total of 120 strains of Pseudomonas aeruginosa, isolated from cystic fibrosis (CF) patients (n = 80) and from patients having extra-pulmonary infections (n = 40) were studied regarding the presence of some virulence factors (hemolysin, gelatinase and elastase production) and presence of the algD and algU genes as detected by polymerase chain reaction-PCR. There was not a significant difference for the production of gelatinase and hemolysin between non-mucoid strains from CF patients and other isolates from extra-pulmonary infections and mucoid strains. The production of elastase was found to be significant among these strains. The algD gene was detected by PCR in all studied strains but the algU gene was detected only in 25% of the mucoid strains....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pseudomonas aeruginosa; Biological characterization; Pathogenesis; Cystic fibrosis; Extra-pulmonary infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100018

Study of bronchoalveolar lavage in HIV-infected children
Provedor de dados: 55
Autores: Sias,Selma Maria de Azevedo; Nunes,Raquel Coronato; Cabral,Livia Maria Maia Nunes; Oliveira,Renata Mendonca de; Rocha,Tamires dos Santos; Cardoso,Claudete Aparecida Araújo.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200031

Study of the relationship between human MIF level, MIF-794CATT5-8 microsatellite polymorphism, and susceptibility of tuberculosis in southwest China
Provedor de dados: 55
Autores: Li,Yanlin; Zeng,Zhaofang; Deng,Shaoli.
OBJECTIVE: To study the human migration inhibitory factor (MIF) level in tuberculosis (TB) patients, and the relationship between MIF-794CATT microsatellite polymorphism and susceptibility of TB in Southwest China. METHODS: TB patients (n = 151) and healthy unrelated controls (n = 149) were recruited for this study. Genomic DNA was extracted, and then amplified by polymerase chain reaction (PCR). MIF-794CATT5-8 microsatellite polymorphism was genotyped by DNA sequencing. MIF level was detected by ELISA. RESULTS: In the TB group, the repeat number of 7/7 and 7/8 (17.89%) was significantly higher than that of the control group (8.05%), and the serum MIF level was also much higher than that of the healthy controls (705.21 ± 67.98 vs. 355.31 ± 57.29 pg/mL, p...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Macrophage migration inhibitory factors; Tuberculosis; Microsatellite polymorphism; Susceptibility.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400013

Study of the relationship between socio-demographic characteristics and new influenza A (H1N1)
Provedor de dados: 55
Autores: Lenzi,Luana; Wiens,Astrid; Grochocki,Mônica Holtz Cavichiolo; Pontarolo,Roberto.
OBJECTIVE: The pandemic of new influenza A (H1N1) has spread rapidly throughout the world, characterized by high transmissibility, but low pathogenicity and virulence. The aim of this study was to understand the pandemic event and available technologies for disease surveillance, prevention, control and management. METHODS: In this retrospective study, we used data from patients in the State of Paraná who had been diagnosed with the disease during the 2009 pandemic. Data were collected from the disease notification form and the study only included patients with confirmed laboratory diagnosis by RT-PCR. RESULTS: We present the epidemiological profile of 4,740 patients that met the inclusion criteria. The variables age, level of schooling and gestational age...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Influenza A virus; H1N1 subtype disease outbreaks causality.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500007

Subacromial bursitis related to HIV infection: case report
Provedor de dados: 55
Autores: Ejnisman,Benno; Figueiredo,Eduardo Antônio de; Terra,Bernardo Barcellos; Lima,Ana Lucia L Munhoz; Uip,David E.
Tipo: Info:eu-repo/semantics/other
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600020

Subclinical infection of the genital tract with Neisseria meningitidis
Provedor de dados: 55
Autores: Lourenço,Maria Cristina S.; Reis,Roberto S.; Andrade,Angela C. V.; Tuyama,Mari; Barroso,David E.
We report the isolation of Neisseria meningitidis, characterized as B:NT:P1.7, from a female patient's genital tract in an outpatient clinic for HIV care. The gynecology clinic, as part of the follow up, collects specimens from all patients with HIV infection for routine exams and for early laboratory detection of sexually transmitted diseases . A Gram-negative diplococcus was isolated from the cervix of a heterosexual patient with AIDS. Based on this and other reported cases, urogenital infection with N. meningitidis can no longer be considered uncommon. The rising incidence of N. meningitidis isolated from this and similar sites has significant medical and diagnostic implications.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Neisseria meningitidis; Genital infection; AIDS.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200015

Subcutaneous emphysema as a clinical finding in emphysematous pyelonephritis
Provedor de dados: 55
Autores: Delfino,Vinicius Daher Alvares; Mansano,Ana Maria Fracaro; Boselli Jr.,José Roberto; Rodrigues,Marco Aurélio de Freitas.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600013

Subcutaneous infection by Graphium basitruncatum in a heart transplant patient
Provedor de dados: 55
Autores: Fernández,Analía L.; Andres,Patricia O.; Veciño,Cecilia H.; Nagel,Claudia B.; Mujica,María Teresa.
ABSTRACT Graphium basitruncatum, a synanamorph of Pseudoallescheria has been rarely reported in human infections. We report a case of subcutaneous phaeohyphomycosis caused by this fungus in a heart transplant recipient. We also describe the phenotypic, molecular methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) used to achieve isolate identification.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Graphium basitruncatum; Phaeohyphomycosis; Heart transplant; Subcutaneous infection.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600670

Success stories about severe pneumonia caused by Panton-Valentine leucocidin-producing Staphylococcus aureus
Provedor de dados: 55
Autores: Elisabeth,Paramythiotou; Maria,Souli; Irene,Galani; Helen,Giamarellou; Apostolos,Armaganidis.
We describe three cases of community-acquired necrotizing pneumonia which were caused by Panton-Valentine leucocidin-producing strains of Staphylococcus aureus (one of them methicillin sensitive). All cases were successfully treated without any sequelae for the patients due to the prompt initiation of adequate antimicrobial therapy. High suspicion toward this fatal pathogen was the key to the successful outcome of the patients.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Community-acquired pneumonia; Clindamycin; Staphylococcus aureus; Panton-Valentine leukocidin.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300341

Successful outpatient management of pelvic actinomycosis by ceftriaxone: a report of three cases
Provedor de dados: 55
Autores: Onal,Eda Demir; Altinbas,Akif; Onal,Ibrahim Koral; Ascioglu,Sibel; Akpinar,Meltem Gulsun; Himmetoglu,Cigdem; Sardan,Yesim Cetinkaya.
Pelvic actinomycosis is a chronic granulomatous suppurative disease caused by actinomyces israeli. Intravenous penicillin is the preferred antimicrobial but it requires hospitalization up to one month. An outpatient treatment strategy would be cost effective and a good choice for patients. Here we present three cases in which intramuscular ceftriaxone was successfully used in the outpatient settings following surgery and IV penicillin treatment in the hospital.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Ceftriaxone; Actinomycosis; Penicillins; Pelvic neoplasms; Intrauterine devices.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500016

Successful prevention of HIV transmission from mother to infant in Brazil using a multidisciplinary team approach
Provedor de dados: 55
Autores: Nogueira,Susie A.; Abreu,Thalita; Oliveira,Ricardo; Araújo,Lúcia; Costa,Tomaz; Andrade,Miriam; Psic,M. Fátima Garcia; Machado,Elizabeth; Rodrigues,Káris; Mercadante,Elizabeth Regina; Fernandes,Iraína; Sapia,M. Conceição; Lambert,John S.
OBJECTIVES: To determine the HIV vertical transmission rate (VTR) and associated risk factors by use of zidovudine and infant care education in Brazil. METHODS: Since 1995, a prospective cohort of HIV infected pregnant women has been followed at the Federal University of Rio de Janeiro. A multidisciplinary team was established to implement the best available strategy to prevent maternal-infant HIV transmission. Patients with AIDS or low CD4 and high viral load received anti-retroviral drugs in addition to zidovudine. Children were considered infected if they had 2 positive PCR-RNA tests between 1 and 4 months of age, or were HIV antibody positive after 18 months. Education regarding infant treatment and use of formula instead of breast feeding was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; HIV; Prevention; Perinatal transmission; Zidovudine.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200006

Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review
Provedor de dados: 55
Autores: Shen,Tian; Wu,Lihua; Geng,Lei; Wei,Zeqing; Zheng,Shusen.
Nocardia infection is rare but potentially fatal. Therapy of Nocardia infection remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, but clinical data are limited. Here we describe a case of a 45-year-old man with pulmonary N. farcinica infection following a liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According to susceptibility test, linezolid was administered with clearly improving the patient's condition. The treatment was stopped for anemia as drug related adverse event, and the therapy lasted for as long as 5 months. At the end of treatment clinical cure was confirmed and anemia reversed after discontinuation of linezolid. We also analyzed the clinical...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nocardia; Linezolid; Drug therapy; Transplantation.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500014

Successful treatment of vancomycin-resistant enterococcus ventriculitis in a child
Provedor de dados: 55
Autores: Silva,Paulo Sérgio Lucas da; Monteiro Neto,Henrique; Sejas,Lílian Márcia.
Enterococci are an uncommon cause of CNS infection. A 20 month-old boy, diagnosed with hydrocephalus with ventriculoperitoneal shunt and history of lengthy hospitalization and use of wide spectrum antibiotics, was admitted to the pediatric intensive care unit diagnosed with ventriculitis. On the 14th day of empirical antibiotic therapy (vancomycin and meropenem) the child presented fever while the CSF sample culture evidenced vancomycin-resistant Enterococcus faecium. The patient received intravenous linezolid achieving cerebrospinal fluid sterilization. Conclusion: Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus ventriculoperitoneal shunt infection.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vancomycin; Resistance; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200027

Successful use of a defined antigen/GM-CSF adjuvant vaccine to treat mucosal leishmaniasis refractory to antimony: a case report
Provedor de dados: 55
Autores: Badaro,Roberto; Lobo,Iza; Nakatani,Maria; Muiños,Alvaro; M. Netto,Eduardo; Coler,Rhea N.; Reed,Steven G.
Immunotherapy has been proposed as a method to treat mucosal leishmaniasis for many years, but the approach has been hampered by poor definition and variability of antigens used, and results have been inconclusive. We report here a case of antimonial-refractory mucosal leishmaniasis in a 45 year old male who was treated with three single injections (one per month) with a cocktail of four Leishmania recombinant antigens selected after documented hypo-responsiveness of the patient to these antigens, plus 50mg of GM-CSF as vaccine adjuvant. Three months after treatment, all lesions had resolved completely and the patient remains without relapse after two years. Side effects of the treatment included only moderate erythema and induration at the injection site...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmaniasis; Immunotherapy; Mucosal leishmaniasis.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400008

Successful use of gentamycin as an antibiotic prophylaxis regimen to reduce the rate of healthcare-associated infections after renal transplantation
Provedor de dados: 55
Autores: Abboud,Cely S.; Bergamasco,Maria Daniela; Sousa,Ercilia Evangelista de; Zandonadi,Eliana de Cássia; Cortez,Doralice.
At our institution, we observed an increase in the incidence of healthcare-associated infections (HAI) due to Gram-negative bacilli, including three cases of carbapenem-resistant Klebsiella pneumoniae, among patients who underwent renal transplantation. In addition to strengthening infection control measures, we chose to add gentamycin to the antibiotic prophylaxis regimen of patients undergoing renal transplantation. We assessed the number of HAI occurring within 30 days of renal transplantation during two time periods: (1) the preintervention period, between September 2009 and June 2010, and (2) the post-intervention period, between July 2010 and April 2011. The intervention consisted of the addition of gentamycin to the surgical antibiotic prophylaxis...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Renal transplantation; Antibiotic prophylaxis; Gentamycin; Health-care associated infections.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200021

Successive mycological nail tests for onychomycosis: a strategy to improve diagnosis efficiency
Provedor de dados: 55
Autores: Meireles,Tereza Elizabeth Fernandes; Rocha,Marcos Fábio Gadelha; Brilhante,Raimunda Sâmia Nogueira; Cordeiro,Rossana de Aguiar; Sidrim,José Júlio Costa.
Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and moulds, accounting for about 50% of onychopathies. A high frequency of onychomycosis caused by Candida species has been reported during the last few years in northeast Brazil, as well as in other regions of the world. A clinical diagnosis of onychomycosis needs to be confirmed through laboratory exams. We evaluated the importance of serial repetition of direct microscopic exams and fungal culture for the diagnosis of onychomycosis in the city of Fortaleza, Ceará, in northeast Brazil. We first made a retrospective study of 127 patients with onychomycosis, identifying the fungi that had been isolated from fingernails and toenails. We then made a prospective study of 120...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diagnosis; Onychomycosis; Candida; Moulds and dermatophytes.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400016

Sulbactam-based therapy for Acinetobacter baumannii infection: a systematic review and meta-analysis
Provedor de dados: 55
Autores: Chu,Haiqing; Zhao,Lan; Wang,Minggui; Liu,Yang; Gui,Tao; Zhang,Jingbo.
BACKGROUND: A number of studies have reported on the effectiveness of sulbactam-based therapies for Acinetobacter baumannii infection; however, there is little evidence that sulbactam-based therapies are more or less effective than alternative therapies. Unfortunately, there is a distinct lack of high quality data (i.e., from randomized controlled trials) available on this issue. Therefore, we conducted a systematic review and meta-analysis comparing the efficacy of sulbactam-based and non-sulbactam-based regimens in the treatment of A. baumannii infection. METHODS: We searched PubMed, MEDLINE, Biomedical Central, Google Scholar, the China National Knowledge Infrastructure, the Cochrane library, and the Directory of Open Access using the terms "sulbactam...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acinetobacter baumannii; Infection; Meta-analysis; Sulbactam; Systematic review.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400001

Superantigens: procession of frets
Provedor de dados: 55
Autores: Aslam,Bilal; Khurshid,Mohsin; Nisar,Muhammad Atif; Muzammil,Saima; Hayat,Sumreen.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300357

Surgical infections: a microbiological study
Provedor de dados: 55
Autores: Saini,Santosh; Gupta,Naveen; Aparna,; Lokveer,; Griwan,M.S.
Surgical infections are mostly polymicrobial, involving both aerobes and anaerobes. One hundred seventeen cases comprised of abscesses (n=51), secondary peritonitis (n=25), necrotizing fascitis (n=22) and wounds with devitalized tissues (n=19) were studied. The number of microorganisms isolated per lesion was highest in secondary peritonitis (2.32). The aerobe/ anaerobe ratio was 0.81 in secondary peritonitis and 1.8 in necrotizing fascitis. Most secondary peritonitis (80%), necrotizing fascitis (75%) and wounds with devitalized tissues (66.7%) were polymicrobial. Common microorganisms isolated in our study were E. coli, Staphylococcus aureus, Klebsiella spp., Pseudomonas aeruginosa, Bacteroides fragilis and Peptostreptococcus spp. The most effective...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Abscess; Secondary peritonitis; Necrotizing fascitis; Wounds with devitalized tissue.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200001

Surgical site infection in a university hospital in northeast Brazil
Provedor de dados: 55
Autores: Medeiros,Aldo Cunha; Aires-Neto,Tertuliano; Azevedo,George Dantas; Vilar,Maria José Pereira; Pinheiro,Laíza Araújo Mohana; Brandão-Neto,José.
We examined prevention of surgical site infection (SSI) in a tertiary teaching hospital in northeast Brazil, from January 1994 to December 2003. The survey included 5,742 patients subjected to thoracic, urologic, vascular and general surgery. The criteria for diagnosing SSI were those of the Centers for Disease Control, USA, and the variables of the National Nosocomial Infection Surveillance risk index were used. Data analysis revealed that anesthetic risk scores, wound class and duration of surgery were significantly associated with SSI. A total of 296 SSIs were detected among the 5,742 patients (5.1%). The overall incidence of SSI was 8.8% in 1994; it decreased to 3.3% in 2003. In conclusion, the use of educational strategies, based on guidelines for SSI...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Surgical site infection; Risk factors; Surveillance.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400007

Surgical-site infection risk in oncologic digestive surgery
Provedor de dados: 55
Autores: Castro,Paulo de Tarso Oliveira e; Carvalho,André Lopes; Peres,Stela Verzinhasse; Foschini,Milene Mitsuyuki; Passos,Afonso Dinis Costa.
Surgical-site infection (SSI) is the most prevalent type of hospital infection in surgical patients and is associated with an increase in hospital stay, costs and morbidity/lethality. The knowledge of the main risk factors for this type of infection is important for the establishment of prevention measures regarding modifiable risks factors. The objective of the preset study was to assess the occurrence of SSI and study the risk factors in oncologic surgeries of the digestive system at Hospital de Câncer in Barretos, São Paulo, Brazil. Individuals undergoing oncologic surgeries of the digestive system in the period of 08/01/2007 to 08/10/2008 were prospectively followed for 30 days after surgery. Possible risk factors related to the patient and to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infection; Surgical site; Oncologic surgery; Digestive system surgery.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200003

Surveillance of pediatric infections in a teaching hospital in Mato Grosso do Sul, Brazil
Provedor de dados: 55
Autores: Chang,M.R.; Carvalho,N.C.P.; Oliveira,A.L.L.; Moncada,P.M.F.; Moraes,B.A.; Asensi,M.D.
Nosocomial infections (NI) result in considerably high mortality and morbidity rates, especially among pediatric patients. Considering current worldwide changes, information about the occurrence of pathogens and susceptibility tests are now seen as decisive for optimizing treatment. The purpose of this research was to determine the frequency of microorganisms, antimicrobial and genetic profiles, and risk factors associated with nosocomial infections in a teaching hospital in Campo Grande, Mato Grosso do Sul. From January 1998 to December 1999, 108 patients were characterized as having nosocomial infection, from which 137 pathogens were isolated. Identification and antimicrobial susceptibility was determined by conventional and automated techniques....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infant; Nosocomial infection; Antimicrobial susceptibility.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200009

Survey of hepatitis B and C infection control: procedures at manicure and pedicure facilities in São Paulo, Brazil
Provedor de dados: 55
Autores: Oliveira,Andréia Cristine Deneluz Schunck de; Focaccia,Roberto.
Bleeding due to the habit of removing the cuticles of the finger and toes nails, without appropriate sterilization of instruments can be an important factor of contamination by hepatitis B and C viruses. The objectives of this study were to verify the use of standards on biosafety in the routine work of manicurists and/or pedicurists located in São Paulo, Brazil; know the level of information they have about ways of transmission and prevention of hepatitis B and C; evaluate the degree of risk perception for accidental exposure to infectious agents; and to estimate the prevalence of serological markers of hepatitis B and C among them. This was descriptive, cross-sectional study that included a random sample of 100 manicurists and/or pedicurists working in...
Tipo: Info:eu-repo/semantics/article
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500013

Survey of Mycoplasma pneumoniae in Iranian children with acute lower respiratory tract infections
Provedor de dados: 55
Autores: Hadi,Nahal; Kashef,Sara; Moazzen,Mohammad; Pour,Michel Shamoon; Rezaei,Nima.
OBJECTIVES: Mycoplasma pneumoniae is an atypical pathogen, which is one of the major causes of lower respiratory tract infections (LRTIs) worldwide. This study was performed to determine the role of M. pneumoniae in acute LRTIs in children, who were referred to main pediatric hospitals in Shiraz, Iran, with the diagnosis of LRTI. Polymerase chain reaction method on a throat-swab specimen was utilized to detect M. pneumoniae. RESULTS: One hundred patients with acute LRTIs were investigated in this study. There were 10 positive PCR for M. pneumoniae (10%), including 6 of 62 hospitalized patients and 4 of 38 outpatients. All patients with LRTIs due to M. pneumoniae had cough. Fever, flu like symptoms, dyspnea, pulmonary rales, wheezing, and conjunctivitis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Atypical bacteria; Mycoplasma pneumoniae; PCR; Respiratory infection.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200001

Surveys of catheter-associated urinary tract infection in a university hospital intensive care unit in China
Provedor de dados: 55
Autores: Xie,Duo-shuang; Lai,Rui-ping; Nie,Shao-fa.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300021

Survival analysis of acquired immune deficiency syndrome patients with and without hepatitis C virus infection at a reference center for sexually transmitted diseases/acquired immune deficiency syndrome in São Paulo, Brazil
Provedor de dados: 55
Autores: Alencar,Wong Kuen; Duarte,Paulo Schiavom; Waldman,Eliseu Alves.
INTRODUCTION:Survival of patients with acquired immune deficiency syndrome has improved with combination antiretroviral therapy; mortality due to liver diseases, however, has also increased in these patients.OBJECTIVES:To estimate the accumulated probability of survival in human immunodeficiency virus-hepatitis C virus coinfected and non-coinfected patients and to investigate factors related to acquired immune deficiency syndrome patients' survival.METHODS:Non-concurrent cohort study using data from surveillance information systems of acquired immune deficiency syndrome patients over 13 years of age. Hepatitis C and B, human immunodeficiency virus exposure category, CD4+ T cell count, age group, schooling, race, sex, and four acquired immune deficiency...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired immunodeficiency syndrome; Hepatitis viruses; Survival analysis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200150

Survival of AIDS patients and characteristics of those who died over eight years of highly active antiretroviral therapy, at a referral center in northeast Brazil
Provedor de dados: 55
Autores: Melo,Ladjane Santos Wolmer de; Lacerda,Heloisa Ramos; Campelo,Eduardo; Moraes,Emanuel; Ximenes,Ricardo Arraes de Alencar.
Introduction of highly active antiretroviral therapy has resulted in a significant reduction in morbimortality and significant changes in the causes of death among HIV/AIDS patients. For this reason, it has become essential to monitor survival and causes of death. We constructed a survival curve based on 597 adult patients notified as AIDS cases between 1997 and 2004, at the Hospital das Clínicas, Federal University of Pernambuco, Recife, Brazil. Among those patients, 150 (25%) progressed to death by December, 2005. Of these, 119 were studied in detail. The data were collected from notification files of the State Health Department and the State Mortality Information System, and were complemented by analysis of medical records. These 597 patients had a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Survival; Cause of death; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400003

Survival of HIV patients with tuberculosis started on simultaneous or deferred HAART in the THRio cohort, Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Saraceni,Valeria; Durovni,Betina; Cavalcante,Solange C.; Cohn,Silvia; Pacheco,Antonio Guilherme; Moulton,Lawrence H.; Chaisson,Richard E.; Golub,Jonathan E.
Background:The timing of highly active antiretroviral therapy (HAART) after a tuberculosis diagnosis in HIV-infected patients can affect clinical outcomes and survival. We compared survival after tuberculosis diagnosis in HIV-infected adults who initiated HAART and tuberculosis therapy simultaneously to those who delayed the start of HAART for at least two months.Methods:The THRio cohort includes 17,983 patients receiving HIV care in 29 public clinics in Rio de Janeiro, Brazil. HAART-naïve patients at the time of a new TB diagnosis between September 2003 and June 2008 were included. Survival was measured in days from diagnosis of TB. We compared survival among patients who initiated HAART within 60 days of TB treatment (simultaneous – ST) to those who...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Tuberculosis; Antiretroviral therapy; Survival.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500491

Susceptibility of S. pneumoniae to various antibiotics among strains isolated from patients and healthy carriers in different regions of Brazil (1999-2000)
Provedor de dados: 55
Autores: Rossi,F.; Andreazzi,D.; Maffucci,M.; Pereira,A A.
Resistance of microbes to commonly used antibiotics became a major concern at the end of the last century. Because Streptococcus pneumoniae is the most common pathogen in respiratory infections, we conducted microbiological assessment of drug susceptibility patterns among strains collected from two different population groups: 1) adult and pediatric patients (375 isolates) with different infections, and 2) healthy children in day care centers (&lt; 5 years old; 350 isolates). High level resistance to penicillin was not identified in either group. Intermediate resistance levels were similar in both groups (adults: 9.9%; children: 9.2%). The Central West region of Brazil tended to have lower susceptibility of S.pneumoniae from infected adults and children to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: S. pneumoniae; Resistance; Susceptibility; Respiratory infection; Antibiotics; Brazil.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600003

Susceptibility of Streptococcus pneumoniae to penicillin in the state of Minas Gerais, Brazil from 1997-2004
Provedor de dados: 55
Autores: Bedran,Maria B. M.; Camargos,Paulo A. M.; Leocádio Filho,Geraldo; Bedran,Renata M.; Najar,Henrique C.
We monitored the susceptibility to penicillin of invasive strains of Streptococcus pneumoniae in two reference laboratories; 502 positive cultures from patients with an active invasive infectious process were analyzed. Streptococcus pneumoniae was identified through conventional procedures, and the oxacillin disc diffusion method was used to check for penicillin susceptibility. Statistical analysis included calculations of the frequency distribution, with 95% confidence intervals (CI), as well as chi-square tests and chi-square for linear trend for temporal analysis of susceptibility. The bacterium was isolated from patients less than a year old (40.7% of the isolates), from infants (55.9%), and from individuals less than 15 years old (64.4%). The majority...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptococcus pneumoniae; Antimicrobial resistance; Invasive disease.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500006

Susceptibility rates in Latin American nations: report from a regional resistance surveillance program (2011)
Provedor de dados: 55
Autores: Jones,Ronald N.; Guzman-Blanco,Manuel; Gales,Ana C.; Gallegos,Belisario; Castro,Aura Lucia Leal; Martino,Marines Dalla Valle; Vega,Silvio; Zurita,Jeannete; Cepparulo,Mario; Castanheira,Mariana.
OBJECTIVE: To establish a resistance (R) surveillance program monitoring antimicrobial susceptibility patterns in Latin America (LATAM; Argentina [ARG], Brazil [BRA], Chile, Colombia [CBA], Costa Rica, Ecuador [ECU], Guatemala [GUA], Mexico [MEX], Panama [PAN], Peru, and Venezuela [VEN]). METHODS: In 2011, 4979 organisms were collected from 11 nations (20 laboratories) for susceptibility testing in a central laboratory design. Antimicrobials were tested by CLSI methods and results interpreted by CLSI and EUCAST breakpoints. Most common Gram-positive (Staphylococcus aureus [SA, 921], other staphylococci [CoNS; 299], enterococci [218], Streptococcus pneumoniae [SPN; 182], β-haemolytic streptococci [115]) and Gram-negative (E. coli [EC; 644], Klebsiella spp....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Latin America; Surveillance; Resistance; ESBL; Β-Lactamases.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600009

Syphilis and HIV-1 among parturient women in Salvador, Brazil: low prevalence of syphilis and high rate of loss to follow-up in HIV-infected women
Provedor de dados: 55
Autores: Nóbrega,Isabella; Dantas,Paula; Rocha,Priscila; Rios,Isabela; Abraão,Marcos; M. Netto,Eduardo; Brites,Carlos.
BACKGROUND: The occurrence of syphilis and HIV-1 infections during pregnancy are major risks to the fetus due to mother-to-child transmission (MTCT). OBJECTIVES: To determine peripartum seroprevalence and risk factors of syphilis and HIV-1 infection among pregnant women in Salvador, Brazil, and the rate of HIV-1 MTCT. METHODS:Cross-sectional study of pregnant women who were admitted for delivery in a reference maternity hospital between May 2008 and March 2009 was conducted. Women were screened for HIV-1 infection and syphilis, and interviewed regarding demographic, behavioral and obstetric data. Newborns to HIV-infected mothers were tested by b-DNA and DNA-PCR to detect HIV-1. RESULTS: A total 3300/8516 women were evaluated. Mean age was 25.8 ± 7.3 years....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human immunodeficiency virus; Syphilis; Seroprevalence; Risk factors; Parturient; Pregnant; Mother-to-child transmission; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200012

Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review
Provedor de dados: 55
Autores: Carmo,Ricardo Andrade; Moura,Alexandre Sampaio; Christo,Paulo Pereira; Morandi,Ana Cláudia; Oliveira,Marcelo Silva.
Few patients with symptomatic neurosyphilis present with signs and symptoms of acute meningitis. Here we report two cases of syphilitic meningitis diagnosed in HIV patients with meningeal syndrome. The first case, a 30-year-old black bisexual male, had concurrent meningeal and ocular syphilis with persistent unusually low CSF glucose levels. He responded well to 21 days of intravenous penicillin therapy. The second case was a 55-year-old female with epilepsy, depression, behavioral disorder and confusion. The diagnosis of HIV infection was made after onset of the syphilitic meningitis. She was treated with 21 days i.v. penicillin with improvement in her clinical condition. The clinical aspects of combined neurosyphilis and HIV infection, plus special...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Meningitis; Neurosyphilis.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500007

T cell receptor signaling pathway is overexpressed in CD4 + T cells from HAM/TSP individuals
Provedor de dados: 55
Autores: Pinto,Mariana Tomazini; Malta,Tathiane Maistro; Rodrigues,Evandra Strazza; Takayanagui,Osvaldo Massaiti; Tanaka,Yuetsu; Covas,Dimas Tadeu; Kashima,Simone.
ABSTRACT Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+ T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsilon (CD3?), lymphocyte-specific protein tyrosine kinase (LCK), vav 1 guanine nucleotide exchange factor (VAV1), and zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70) on T lymphocytes of HTLV-1-infected individuals and compared to healthy uninfected individuals (CT). We observed that CD3?, LCK, ZAP70, and VAV1 gene expression were increased in CD4+ T cells from HAM/TSP group compared to HTLV-1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; HAM/TSP; CD4+ T cell activation; Gene expression.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600578

T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality
Provedor de dados: 55
Autores: Costa,Ramon Teixeira; Araújo,Orlei Ribeiro de; Brunialti,Milena Karina Coló; Assunção,Murilo Santucci Cesar; Azevedo,Luciano César Pontes; Freitas,Flávio; Salomão,Reinaldo.
ABSTRACT  Objective: We evaluated the kinetics of cytokines belonging to the T helper1 (Th1), Th2, and Th17 profiles in septic patients, and their correlations with organ dysfunction and hospital mortality.  Methods: This was a prospective observational study in a cohort of septic patients admitted to the intensive care units (ICU) of three Brazilian general hospitals. A total of 104 septic patients and 53 health volunteers (controls) were included. Plasma samples were collected within the first 48 h of organ dysfunction or septic shock (0D), after seven (D7) and 14 days (D14) of follow-up. The following cytokines were measured by flow cytometry: Interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, IL-12/23p40, IL-17, IL-21, tumor necrosis factor-α (TNF-α),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Cytokines; Th response; Organ dysfunction; SOFA.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200079

Tailoring antimicrobials in febrile neutropenia: using faster diagnostic and communication tools to improve treatment in the era of extensively resistant pathogens
Provedor de dados: 55
Autores: Souza,Ingvar Ludwig Augusto de; Quiles,Milene Gonçalves; Boettger,Bruno Cruz; Pignatari,Antonio Carlos Campos; Cappellano,Paola.
ABSTRACT Febrile Neutropenia represents a medical emergency and the use of appropriate antimicrobial therapy is essential for a better outcome. Although being time-consuming, conventional cultures and antimicrobial susceptibility tests remain the golden standard practices for microbiology identification. Final reports are typically available within several days. Faster diagnostic tools, such as species identification trough Matrix Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) and molecular techniques might help to shorten time to diagnostic and also guide definitive therapy in this scenario. Here we present a case in which the use of a diagnostic molecular workflow combining MALDI-TOF and real-time PCR for relevant genes codifying...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Febrile Neutropenia; Molecular Diagnosis; Mass Spectrometry; Communication.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300239

Targeted preemptive therapy according to perceived risk of CMV infection after kidney transplantation
Provedor de dados: 55
Autores: Pinto,Cahue Henrique; Tedesco-Silva Jr,Helio; Felipe,Claudia Rosso; Ferreira,Alexandra Nicolau; Cristelli,Marina; Viana,Laila Almeida; Aguiar,Wilson; Medina-Pestana,José.
ABSTRACT  Background: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and the associated costs. This study investigated the efficacy and safety of targeted preemptive therapy according to perceived risk of cytomegalovirus infection after kidney transplantation.  Methods: 144 adult kidney transplant recipients were enrolled in this 12-month study. None received cytomegalovirus pharmacological prophylaxis. Only high risk patients (positive donor/negative recipient (D+/R−), use of induction therapy with antithymocyte globulin, treatment of rejection) received preemptive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Kidney; Transplant; Preemptive therapy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600576

Tattoos and transfusion-transmitted disease risk: implications for the screening of blood donors in Brazil
Provedor de dados: 55
Autores: Nishioka,Sérgio de A.; Gyorkos,Theresa W.; MacLean,J. D.
Having a tattoo has been associated with serological evidence of hepatitis B and C viruses, as well as human immunodeficiency virus infections and syphilis; all of these are known to be transmissible by blood transfusion. These associations are of higher magnitude for individuals with nonprofessionally-applied tattoos and with two or more tattoos. Tattoos are common among drug addicts and prisoners, conditions that are also associated with transfusion-transmitted diseases. We examined the implications of these associations for the screening of blood donors in Brazil. Numbers of individuals who would be correctly or unnecessarily deferred from blood donation on the basis of the presence of tattoos, and on their number and type, were calculated for different...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; Blood donors; Screening; Tattoos; Transfusion-transmitted diseases.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400004

Tatumella ptyseos causing severe human infection: report of the first two Brazilian cases
Provedor de dados: 55
Autores: Costa,Paulo Sérgio Gonçalves da; Mendes,Juliana Monteiro de Castro; Ribeiro,Geyza Machado.
Tatumella ptyseos is the type species of the Tatumella genus (Enterobacteriaceae). This fermentative Gram-negative rod has only rarely been reported as a cause of human infections; there is very little information about it in the medical literature. We report here the first two Brazilian cases of T. ptyseos infections, both evolving to severe sepsis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tatumella ptyseos; Sepsis; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500017

Tema Livre
Provedor de dados: 55
Tipo: Info:eu-repo/semantics/other
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000100016

Temporal evolution of the prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Bahia, Brazil: a nine-year evaluation study
Provedor de dados: 55
Autores: Brites,Carlos; Silva,Nanci; Sampaio- Sá,Márcia.
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become an increasing problem in Brazilian hospitals within the last years. In Bahia, there is scarce information on the epidemiological characteristics of MRSA infections and their determinants. The objective of this study was to evaluate the temporal evolution of MRSA infections in a private, tertiary hospital, in Salvador, the capital of the state of Bahia. We reviewed the microbiological records of bacterial isolates from the Hospital Espanhol, a 300 bed, general hospital, in Salvador. We analyzed the frequency of positive cultures for S. aureus during the last nine years, the prevalence of MRSA, and the spatial distribution of the isolates in the hospital. We also evaluated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; MRSA; Bacterial resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400003

Terry's nails
Provedor de dados: 55
Autores: Li,Zhengxiao; Ji,Fanpu; Deng,Hong.
Tipo: Info:eu-repo/semantics/article
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300021

Tertiary syphilis: tubero-serpiginous and tubero-ulcerous syphilids
Provedor de dados: 55
Autores: Jorge,Lívia Montelo Araújo; da Costa Nery,José Augusto; Filho,Fred Bernardes.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300016

Testicular schistosomiasis caused by Schistosoma mansoni: a case report from Brazil
Provedor de dados: 55
Autores: Lopes,Roberto Iglesias; Leite,Kátia Ramos; Prando,Décio; Lopes,Roberto Nicomedes.
Testicular schistosomiasis by Schistosoma mansoni is exceedingly rare, with only 11 cases reported in PubMed. We report a new case from Brazil. A 31-year-old man from the northeast region of the country presented with a 2 cm nodule in the right testis. Ultrasonography showed a well-delimited hypoechoic tumor, suggestive of a granulomatous lesion. Magnetic resonance imaging revealed an irregular tunica albuginea signal. A biopsy showed interstitial tissue with schistosome ova and granuloma formation. The nodule was excised, and the patient was treated with oxamniquine. He has remained symptom free for 10 years. A testicular nodule should raise suspicion of numerous pathologies, including schistosomiasis. Treatment should include therapy with oxamniquine or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Testis; Schistosomiasis; Orchiectomy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500015

The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine intracranial abscesses model
Provedor de dados: 55
Autores: Gong,Jian; Li,Dongzhi; Yan,Jun; Liu,Yu; Li,Di; Dong,Jie; Gao,Yaping; Sun,Tao; Yang,Guang.
Background:Intracranial abscesses are associated with high mortality. Staphylococcus aureus is one of the main pathogens that cause intracranial infection. Until now, there is no report to identify the key effectors of S. aureus during the intracranial infection.Methods:The murine intracranial abscesses model induced by S. aureuswas constructed. The vital sign and survival rate of mice were observed to evaluate the infection. Histological examination was used to diagnose the pathological alterations of mouse tissues. The sensitivity of S. aureus to whole blood was evaluated by whole-blood killing assay.Results:In murine intracranial abscesses model, it was shown that the mortality caused by the accessory gene regulator (agr) locus deficient strain was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: S. aureus; Agr; Intracranial abscesses model.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500501

The application of latent class analysis for diagnostic test validation of chronic Trypanosoma cruzi infection in blood donors
Provedor de dados: 55
Autores: Langhi Junior,Dante M.; Bordin,José O.; Castelo,Adauto; Walter,Stephen D.; Moraes-Souza,Hélio; Stumpf,Robert J.
The main strategy to prevent transfusion-associated Chagas' disease is the identification of T. Cruzi-infected blood donors by serological screening tests, however there is no perfect serological gold standard. We evaluated an enzyme immunoassay (EIA), an indirect hemaglutination (IHA), and an indirect immunofluorescence (IIF) test for detecting T. Cruzi antibodies in Brazilian blood donors. The results were submitted to latent class analysis, and a radioimmunopreciptation (RIPA) test was performed on repeatedly positive samples. Among 1951 donors, 11 (0.56%) were positive by EIA, 6 (0.31%) by IHA and 16 (0.82%) by IIF. Six samples were positive with all tests, while 4 reacted with EIA and IIF. The RIPA was positive in 6 (75.0%), 7 (66.6%), and 4 (54.0%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chaga's disease; Blood donors; Diagnostic test; Latent class analysis.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400005

The assessment of infection control in dental practices in the municipality of São Paulo
Provedor de dados: 55
Autores: Matsuda,Jacqueline Kimiko; Grinbaum,Renato Satovschi; Davidowicz,Harry.
OBJECTIVE: The goal of this study was to evaluate the infection control measures actually implemented by dental surgeons during dental practice, as patients and professionals are exposed to high biological risk in dental care environments. METHOD: 614 questionnaires (90.69%) were answered by professionals registered in updating or in post-graduate courses in the Municipality of São Paulo. RESULTS: Out of surveyed professionals 30.62% admitted that surface protection barriers were not used, whereas 34.17% were using non ideal or outdated pre-disinfection practices. The autoclave was used by 69.38% of participants, although 33.80% were not monitoring control of the sterilization cycles. Chemical and biological indicators were not used simultaneously by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infection control; Sterilization; Occupational accidents; Dentistry.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100009

The association of HLA-DRB1 alleles and drug use with HIV infection in a Chinese Han Cohort
Provedor de dados: 55
Autores: Diao,Bo; Du,Juan; Liu,Ying; Luo,Fan; Hou,Wei.
Objective:To investigate the relationship between the polymorphism of human leukocyte antigen (HLA)-DRB1 and the susceptibility and repellency of drug use combined with HIV infection in Chinese.Methods:A total of 213 unrelated healthy people, 41 HIV-infected drug users, 24 HIV-uninfected drug users, and 64 HIV-infected non-drug users were recruited. Their HLA-DRB1 allele frequencies were analyzed by PCR-SSP and allele distribution was analyzed.Results:Compared with healthy controls, in drug users, the frequencies of HLA-DRB1 *0401-041, *1001 were significantly higher; in HIV-infected patients, the frequencies of HLA-DRB1 *0101-0103, *0401-0411, *1001 were significantly higher, while the frequencies of DRB1 *1501-1502, *1101-1105, *1301-1302, DRB4, DRB5...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HLA-DRB1; Polymorphism; Drug use combined with HIV; Infection; Frequency.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100082

The beta-chemokines MIP-1alpha and RANTES and lipoprotein metabolism in HIV-infected brazilian patients
Provedor de dados: 55
Autores: Mikawa,Angela Yumico; Malavazi,Iran; Tagliavini,Sandra Antonia; Abrão,Emiliana P.; Costa,Paulo Inácio da.
HIV patients are predisposed to the development of hypertriglyceridemia and hypercholesterolemia as a result of both viral infection and HIV infection therapy, especially the protease inhibitors. Chemokines and cytokines are present at sites of inflammation and can influence the nature of the inflammatory response in atherosclerosis. We investigated the correlation between biochemical variables and beta-chemokines (MIP-1alpha and RANTES) and the apolipoprotein E genotype in HIV-infected individuals. The apolipoproteins were measured by nephelometry. Triglycerides and total cholesterol were determined by standard enzymatic procedures. The beta-chemokines were detected by ELISA. The genetic category of CCR5 and apolipoprotein E were determined by PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beta- chemokine; HIV; Genotype; Lipoproteins; Cholesterol; Triglyceride.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400008

The burden of sepsis in critically ill human immunodeﬁciency virus-infected patients-a brief review
Provedor de dados: 55
Autores: Moreira,José.
Since the advent of highly active antiretroviral therapy in 1996, we have seen dramatic changes in morbi-mortality rates from human immunodeﬁciency virus-positive patients. If on the one hand, the immunologic preservation-associated with the use of current antiretroviral therapy markedly diminishes the incidence of opportunistic infections, on the other hand it extended life expectancy of human immunodeﬁciency virus-infected individuals similarly to the general population. However, the management of critically ill human immunodeﬁciency virus-infected patients remains challenging and troublesome for practicing clinician. Sepsis - a complex systemic inﬂammatory syndrome in response to infection - is the second leading cause of intensive care unit admission...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Human immunodeﬁciency virus; Highly active antiretroviral therapy; Intensive care.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100077

The carriage of the serine-aspartate repeat protein-encodingsdr genes among Staphylococcus aureuslineages
Provedor de dados: 55
Autores: Liu,Huanle; Lv,Jingnan; Qi,Xiuqin; Ding,Yu; Li,Dan; Hu,Longhua; Wang,Liangxing; Yu,Fangyou.
ABSTRACTThe serine-aspartate repeat proteins (Sdr) are members of a family of surface proteins and contribute to the pathogenicity of Staphylococcus aureus. Among 288 S. aureus isolates including 158 and 130 associated with skin and soft tissue infections and bloodstream infection, respectively; 275 (95.5%) were positive for at least one of threesdr genes tested. The positivity rates for sdrC, sdrD, and sdrE among S. aureusisolates were 87.8% (253/288), 63.9% (184/288), and 68.1% (196/288), respectively. 224 (77.8%) of 288 isolates were concomitantly positive for two or three sdr genes. There was an association between carriage ofsdrE and methicillin-resistant S. aureus(MRSA) isolates, while the carriage rates of sdrC andsdrD in MRSA isolates were similar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus; Sdr genes; Clonal lineages.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500498

The changing pattern of methicillin-resistant staphylococcus aureus clones in Latin America: implications for clinical practice in the region
Provedor de dados: 55
Autores: Rodríguez-Noriega,Eduardo; Seas,Carlos.
Methicillin-resistant Staphylococcus aureus (MRSA) clones belonging to the Brazilian, Pediatric, Cordobes/Chilean and New York/Japan clonal complexes are widely distributed across Latin America, although their individual distribution patterns and resistance to antimicrobial drugs are constantly changing. Furthermore, clones with increased virulence are beginning to appear more frequently both in hospital and community settings, and there is evidence that virulence factors can be transferred between hospital- and community-associated clones through recombination. These changing patterns have significant implications for clinical practice in the region. Most importantly, clinicians need to be aware of the changing antimicrobial resistance profile of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Clones; Molecular epidemiology; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800004

The clinical effectiveness of pegylated interferon and ribavirin for the treatment of chronic hepatitis C in HIV-infected patients in Brazil: a multicentric study
Provedor de dados: 55
Autores: Ferreira,Paulo Roberto Abrão; Silva,Mariliza Henrique da; Brandão-Melo,Carlos Eduardo; Rezende,Rosamar Eulira; Gonzalez,Mário; Reuter,Tânia; Urbaez,Jose David; Gianini,Reinaldo Jose; Martinelli,Ana; Mendes-Correa,Maria Cássia.
Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeﬁciency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identiﬁcation of the factors that predict sustained virological response (SVR) under current clinical practice would enable clinicians to more accurately estimate the probability of achieving an SVR and therefore utilize the appropriate therapeutics, especially in the era of direct-acting antiviral (DAA) agents.Aims: the primary aim of our study was to determine the SVR rate under current clinical practice. The secondary aims were as follows: (1) to determine the factors...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon Ribavirin HCV; HIV.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100015

The clinical features and outcomes of acute liver failure associated with dengue infection in adults: a case series
Provedor de dados: 55
Autores: Tan,Soek-Siam; Bujang,Mohamad Adam.
OBJECTIVE: To describe the clinical manifestations and outcome of acute liver failure (ALF) associated with dengue viral infection, a rare but severe complication. METHODS: One hundred and fifty five consecutive patients with ALF admitted to the national liver centre from 2001 to 2009 were reviewed retrospectively. Eight cases due to dengue infection were identified and their clinical characteristics are described. RESULTS: All patients had severe dengue with one dengue shock syndrome. The median (minimum, maximum) age was 33.5 (17, 47) years with 50% female. The median (minimum, maximum) duration from the onset of fever to development of ALF was 7.5 (5, 13) days and the maximum hepatic encephalopathy (HE) grade were III in five patients and II in three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute liver failure; Dengue; Dengue hepatitis; Fulminant hepatic failure.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200008

The clinical utility of induced sputum for the diagnosis of bacterial community-acquired pneumonia in HIV-infected patients: a prospective cross-sectional study
Provedor de dados: 55
Autores: Silva,Rosemeri Maurici da; Teixeira,Paulo José Zimermann; Moreira,José da Silva.
BACKGROUND: Bacterial pneumonias have been overcoming pneumocytosis in frequency. Controversy still remains about how to manage immunocompromised patients and those with lung diseases. Sputum analysis is a noninvasive and simple method, and when interpreted according to specific criteria it may help with diagnosis. We conducted a study to evaluate sensitivity, specificity, positive and negative predicted values, and the accuracy of induced sputum (IS) for bacterial community-acquired pneumonia diagnosis in HIV-positive patients. MATERIAL AND METHODS: This cross sectional study evaluated a diagnostic procedure in a reference hospital for HIV patients in Florianópolis, SC, Brazil. From January 1, 2001 to September 30, 2002, 547 HIV-positive patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Induced sputum; HIV; Bacterial pneumonia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200004

The descriptive and molecular epidemiology of HHV-8 among population groups of the Amazon region of Brazil
Provedor de dados: 55
Autores: Ishak,R.; Martins,R.N.; Machado,L.F.A.; Vallinoto,A.C.R.; Lobato,L.; Sata,T.; Ishak,M.O.G.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500018

The effectiveness of a bundle in the prevention of ventilator-associated pneumonia
Provedor de dados: 55
Autores: Ferreira,Cléria Rodrigues; de Souza,Denis Fabiano; Cunha,Thulio Marques; Tavares,Marcelo; Reis,Samir Seme Arab; Pedroso,Reginaldo Santos; Röder,Denise Von Dolinger de Brito.
Abstract  Objectives The aim of this study was to evaluate the impact of a bundle called FAST HUG in ventilator-associated pneumonia, weigh the healthcare costs of ventilator-associated pneumonia patients in the intensive care unit, and hospital mortality due to ventilator-associated pneumonia.  Material and methods The study was performed in a private hospital that has an 8-bed intensive care unit. It was divided into two phases: before implementing FAST HUG, from August 2011 to August 2012 and after the implementation of FAST HUG, from September 2012 to December 2013. An individual form for each patient in the study was filled out by using information taken electronically from the hospital medical records. The following data was obtained from each...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator-associated pneumonia; Checklist; Cost; Mortality.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300008

The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study
Provedor de dados: 55
Autores: Moghadami,Mohsen; Dadashpour,Nazanin; Mokhtari,Ali Mohammad; Ebrahimi,Mostafa; Mirahmadizadeh,Alireza.
ABSTRACT  Introduction: Hepatitis B virus (HBV) is responsible for one of the most common human viral infections. An estimated 257 million people are living with chronic HBV infection worldwide, and mortality has reached 900,000 deaths in recent years. In 2001, the World Health Organization reported a prevalence of chronic hepatitis B infection in Iran between 2-7%.  Objective: To assess the effect of the national HBV mass vaccination program after 25 years.  Methods: A retrospective cohort study was conducted in vaccinated and unvaccinated people according to the year of birth. Blood samples were obtained from each enrolled person and data about demographic variables, and medical and vaccination history were collected using a standardized questionnaire....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Vaccination; Effectiveness research.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600419

The effects of nitric oxide on the immune response during giardiasis
Provedor de dados: 55
Autores: Pavanelli,Wander Rogério; Gutierrez,Fredy Roberto Salazar; Silva,Jean Jerley Nogueira da; Costa,Ivete Conchon; Menezes,Maria Claudia Noronha Dutra de; Oliveira,Francisco José de Abreu; Itano,Eiko Nakagawa; Watanabe,Maria Angélica Ehara.
Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-synthases. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to pathological states. The knowledge of effects of NO has been not only important to our understanding of immune response, but also to new tools for research and treatment of various diseases. Knowing the importance of NO as inflammatory mediator in diverse infectious diseases, we decided to develop a revision that shows the participation/effect of this mediator in immune response induced against Giardia spp. Several studies already demonstrated the participation of NO with microbicidal and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nitric oxide; Immune system; Giardiasis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600010

The emerging of the fifth malaria parasite (Plasmodium knowlesi): a public health concern?
Provedor de dados: 55
Autores: Sabbatani,Sergio; Fiorino,Sirio; Manfredi,Roberto.
After examining the most recent scientific evidences, which assessed the role of some malaria plasmodia that have monkeys as natural reservoirs, the authors focus their attention on Plasmodium knowlesi. The infective foci attributable to this last Plasmodium species have been identified during the last decade in Malaysia, in particular in the states of Sarawak and Sabah (Malaysian Borneo), and in the Pahang region (peninsular Malaysia). The significant relevance of molecular biology assays (polymerase chain reaction, or PCR, performed with specific primers for P. knowlesi), is underlined, since the traditional microscopic examination does not offer distinguishing features, especially when the differential diagnosis with Plasmodium malariae is of concern....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria parasites; Plasmodium knowlesi; Emerging plasmodia; Human health; Public health concerns.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300019

The environmental cofactors in carcinogenesis in high risk HPV/HIV-positive women
Provedor de dados: 55
Autores: Paulo,Michele; Borges,Alex Bittencourt; Duarte,Geraldo; Quintana,Silvana Maria; Montes,Marlise Bonetti Agostinho; Toloi,Maria Regina Torqueti.
The objective of the present study was to assess the presence of human papilloma virus (HPV) in HIV-infected women, with comparison between the Papanicolaou cytologic technique and the molecular PCR technique, as well as to determine the type of HPV, to measure cellular immunocompetence and to identify the presence of risk factors for the acquisition of HPV infection. Thirty HIV-infected women were selected. Vaginal and endocervical samples were collected from 27 of them. The smears were examined by 3 experienced cytologists to diagnose the presence of HPV by the Papanicolaou technique and the results were compared to HPV detection and typing by PCR. HPV-infected patients were interviewed in order to identify the presence of risk factors for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; HIV-infected women; Cervical cancer; Carcinogenesis; Antiretroviral therapy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200003

The epidemiology and clinical features of Mycoplasma pneumoniae infection in neonates
Provedor de dados: 55
Autores: Huang,Feng; Lu,Lianghua; Jiang,Wujun; Yan,Yongdong; Ji,Wei; Yang,Bin; Yu,Shenglin.
Abstract  Objectives This retrospective study was aimed to explore the epidemiological and clinical profiles of Mycoplasma pneumoniae infection in neonates.  Methods From 2011 to 2014, 1322 hospitalized neonates with lower respiratory tract infections were screened for Mycoplasma pneumoniae by detection of Mycoplasma pneumoniae antibodies using Serion ELISA classic Mycoplasma pneumoniae kits.  Results Mycoplasma pneumoniae was identified in 89 (6.7%) patients. The age ranged from 1 day to 28 days with a median of 22 days. The male to female ratio was 1.15:1. Mycoplasma pneumoniae infection peaked in spring (from March through May) and winter (from December through February). Compared with non-Mycoplasma pneumoniae infected neonates, those with Mycoplasma...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lower respiratory tract infection; Neonate; Mycoplasma pneumoniae.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400374

The epidemiology of sepsis in a Brazilian teaching hospital
Provedor de dados: 55
Autores: Kauss,IAM; Grion,Cintia MC; Cardoso,LTQ; Anami,EHT; Nunes,LB; Ferreira,GL; Matsuo,T; Bonametti,AM.
OBJECTIVES: The objective of this study was to estimate disease incidence and mortality rate of sepsis in a tertiary public hospital. METHODS: Patients admitted to the Intensive Care Unit (ICU) in 2004 and 2005 were monitored for sepsis using an observational longitudinal study design. Patients were monitored daily for diagnostic criteria of sepsis, according to ACCP/SCCM Consensus Conference criteria, until either death or hospital discharge. RESULTS: During the study, we analyzed 1,179 patients. Systemic Inflammatory Response Syndrome (SIRS) was present in 1,048 (88.9%) patients on admission, and was associated with infection in 554 (47.0%) patients. Of these, sepsis was diagnosed in 30 (2.5%) patients, while severe sepsis was diagnosed in 269 (22.8%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Incidence; Mortality; Epidemiology.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300011

The evaluation of bacteriology in perianal abscesses of 81 adult patients
Provedor de dados: 55
Autores: Ulug,Mehmet; Gedik,Ercan; Girgin,Sadullah; Celen,Mustafa Kemal; Ayaz,Celal.
OBJECTIVE: Treatment of perianal abscesses requires prompt surgical drainage and antimicrobial therapy. However, we should encourage the selective use of antimicrobial agents on a case-by-case basis, especially because there is no evidence that uncomplicated perianal abscesses can be safely treated only with drainage. For this reason, it is important to identify the causative organisms; therefore, we accessed the microbiological analysis of these patients. PATIENTS AND METHODS: In this study, 81 consecutive adult patients with perianal abscesses, who presented at a university hospital in Diyarbakir from January 2004 to December 2006, were included. Clinical and laboratory data, and results of microbiological analysis were recorded. RESULTS: All specimens,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Perianal abscess; Adult; Bacteriology; Aerobic bacteria; Treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300005

The evolution of the resistance of Staphylococcus aureus found on healthcare workers correlated with local consumption of antibiotics
Provedor de dados: 55
Autores: Busato,César Roberto; Gabardo,Juarez; Leão,Maria Terezinha Carneiro.
OBJECTIVE: Correlate the evolution of the resistance of Staphylococcus aureus collected from healthcare workers with the local consumption of antibiotics. MATERIAN AND METHODS: Open prospective research.Study Site. General Reference Hospital with 200 beds in a 700,000 inhabitant region, in Ponta Grossa, Paraná, Brazil. RESULTS: Two collections (samples) of Staphylococcus aureus isolates were obtained from healthcare-workers during an approximate four-year interval. Samples 1 (n= 200) and 2 (n= 270) had this bacterium in 63 (32%) and 90 (33%) of the patients, respectively. At the same time, the annual consumption of antibiotics in DDD/1,000 patient-days was determined. The variation of resistance was significantly smaller (m.s.d.=12.11) for gentamycin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Staphylococcus aureus nasal carriage; Health-care workers; Resistance and antibiotic consumption.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300006

The fast transmission of infectious diseases around the world – a new concern to the public health
Provedor de dados: 55
Autores: Fujita,Dennis Minoru; Nali,Luiz Henrique da Silva; Urbano,Paulo Roberto; Soeiro,Débora Maringoni; Andrade Jr.,Heitor Franco de.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500513

The first case of AIDS due to occupational exposure in Brazil
Provedor de dados: 55
Autores: Santos,Naila Janilde Seabra; Monteiro,Ana Lúcia Carvalho; Ruiz,Emily Anna Catapano.
The first case of AIDS due to occupational exposure in Brazil is described. The accident occurred in 1994 and the health care worker was classified as AIDS-positive with unidentified risk in 1997. The correct classification as occupational exposure occurred after an epidemiological investigation conducted in 1999.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV/Aids; Professional exposure; Brazil.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000300007

The first outbreak of measles virus caused by imported genotype D8 in Jiangsu province of China
Provedor de dados: 55
Autores: Deng,Xiuying; Hu,Ying; Lu,Peishan; Zhou,Ming-hao; Guo,Hongxiong.
ABSTRACT Here we reported the outbreak of measles cases caused by the genotype D8 measles virus for the first time in Jiangsu province in China, which was possibly imported by a foreign student from Laos. Throat swab specimens were collected, and used to isolate virus. 634-bp fragment of the N gene and 1854-bp fragment of H gene were amplified by reverse transcription-PCR and sequenced, respectively. Phylogenetic results indicated that they belonged to genotype D8 measles virus. Further epidemiology investigation showed that the adults with D8 measles virus infection did not receive measles vaccine before having measles. In China, almost all D8 genotype MeV only infected those population without receiving measles vaccine immunization. Therefore, it is...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Measles virus; Imported D8 genotype; Outbreak.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100066

The halo sign of Q fever pneumonia
Provedor de dados: 55
Autores: Zhang,Yi; Zang,Guo-Qing; Tang,Zheng-Hao; Yu,Yong-Sheng.
Tipo: Info:eu-repo/semantics/report
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200220

The impact of AIDS on birth control
Provedor de dados: 55
Autores: Coutinho,Elsimar.
Tipo: Info:eu-repo/semantics/other
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200012

The impact of dengue on liver function as evaluated by aminotransferase levels
Provedor de dados: 55
Autores: Souza,Luiz José de; Nogueira,Rita Maria Ribeiro; Soares,Leandro Cordeiro; Soares,Carlos Eduardo Cordeiro; Ribas,Bruno Fernandes; Alves,Felipe Pinto; Vieira,Fabíola Rodrigues; Pessanha,Felipe Eulálio Baldi.
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1%...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Dengue hemorrhagic fever; Aminotransferases; Hepatitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007

The impact of ocular tuberculosis on vision after two months of intensive therapy
Provedor de dados: 55
Autores: Oliveira,Suzana Batista Vereza de; Passos,Ângelo Ferreira; Hadad,David Jamil; Zbyszynski,Lorena; Sousa de Almeida Júnior,Pedro; Castellani,Luiz Guilherme Schmidt; Dietze,Reynaldo; Palaci,Moisés.
ABSTRACT Tuberculosis is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary tuberculosis patients, seven disseminated tuberculosis, and three pleural tuberculosis patients was evaluated. All patients underwent routine ophthalmic evaluation, including assessment of visual acuity, biomicroscopy, applanation tonometry, indirect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Eye; Visual acuity; Treatment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300159

The impact of urinary incontinence on the quality of life and on the sexuality of patients with HAM/TSP
Provedor de dados: 55
Autores: Gascón,Maria Rita Polo; Mellão,Mirella de Almeida; Mello,Sandra Helena; Negrão,Rosangela Maria; Casseb,Jorge; Oliveira,Augusto César Penalva de.
ABSTRACT This study evaluated the impact of urinary incontinence (UI) on sexuality, body image, mood, and quality of life of patients with myyelopathy associated with HTLV-1/tropical spastic paraparesis (HAM/TSP). The sample consisted of 31 HAM/TSP outpatients, of both sexes, followed-up at the Emílio Ribas Infectology Institute. The following instruments were used: sociodemographic questionnaire, Hospital Anxiety and Depression Scale (HAD), Body Image Assessment Scale, Sexual Quotient Female (QS-F) and Male (QS-M) Versions, King's Health Questionnaire (KHQ), and Revised OSAME Motor Disability Score. Data analysis was performed using descriptive statistics and the Mann-Whitney U-test was used for group comparison. The presence of UI was reported by 13...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HAM/TSP; Quality of life; Urinary incontinence.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400288

The importance of the doctor-patient relationship in adherence to HIV/AIDS treatment: a case report
Provedor de dados: 55
Autores: Garcia,Rosa; Lima,Manuela Garcia; Gorender,Miriam; Badaró,Roberto.
In this case report, which includes a statement related by the patient himself, the authors also discuss the importance of a good doctor-patient relationship in treating HIV patients and in assuring the patient's adherence to his treatment. Related issues, such as the importance of treating psychiatric comorbidities, of preserving the patient's hope and motivation, and of giving him an adequate amount of information regarding the disease and its treatment, are also discussed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adherence; Doctor-patient relationship; HIV; AIDS; Psychiatric comorbidities.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300008

The in vitro activity of ceftazidime-avibactam against 417 Gram-negative bacilli collected in 2014 and 2015 at a teaching hospital in São Paulo, Brazil
Provedor de dados: 55
Autores: Rossi,Flávia; Cury,Ana P.; Franco,Maria R.G.; Testa,Raymond; Nichols,Wright W.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500569

The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir
Provedor de dados: 55
Autores: Schröeder,Regina; Michelon,Tatiana; Wurdig,João; Fagundes,Iara; Schio,Sadi; Sanchez,Leticia; Camargo,José J.; Sukkienik,Teresa C.; Pasqualotto,Alessandro C.; Neumann,Jorge.
The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Antigenemia; Lung transplantation; Ganciclovir; Prophylaxis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200008

The influence of HCV coinfection on clinical, immunological and virological responses to HAART in HIV-patients
Provedor de dados: 55
Autores: Carmo,Ricardo A.; Guimarães,Mark D.C.; Moura,Alexandre S.; Neiva,Augusto M.; Versiani,Juliana B.; Lima,Letícia V.; Freitas,Lílian P.; Rocha,Manoel Otávio C.
The potential impact of the hepatitis C virus (HCV) on clinical, immunological and virological responses to initial highly active antiretroviral therapy (HAART) of patients infected with human immunodeficiency virus (HIV) is important to evaluate due to the high prevalence of HIV-HCV coinfection. A historical cohort study was conducted among 824 HIV-infected patients starting HAART at a public referral service in Belo Horizonte, Brazil, to assess the impact of HCV seropositivity on appearance of a new AIDS-defining opportunistic illness, AIDS-related death, suppression of viral load, and an increase in CD4-cell count. A total of 76 patients (9.2%) had a positive HCV test, 26 of whom (34.2%) had a history of intravenous drug use. In multivariate analysis,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV/HCV coinfection Brazil antiretroviral therapy mortality morbidity.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300003

The influence of occult infection with hepatitis B virus on liver histology and response to interferon treatment in chronic hepatitis C patients
Provedor de dados: 55
Autores: Silva,Claudia da; Gonçales,Neiva Sellan Lopes; Pereira,Josiane Silveira Felix; Escanhoela,Cecília Amélia Fazio; Pavan,Maria Helena Postal; Gonçales Junior,Fernando Lopes.
Occult hepatitis B virus (HBV) infections have been identified in patients with chronic hepatitis C virus (HCV) infection, although the clinical relevance of occult HBV infection remains controversial. We searched for serum HBV DNA in 106 HBsAg negative/anti-HBc positive patients with chronic HCV infection and in 150 blood donors HBsAg negative/anti-HBc positive/anti-HCV negative (control group) by nested-PCR. HCV genotyping was done in 98 patients and percutaneous needle liver biopsies were performed in 59 patients. Fifty-two patients were treated for HCV infection with interferon alone (n=4) or combined with ribavirin (n=48) during one year. At the end and 24 weeks after stopping therapy, they were tested for HCV-RNA to evaluate the sustained virological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Occult HBV infection chronic HCV infection HBV-DNA PCR; HCV genotype interferon treatment.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600007

The influenza season 2016/17 in Bucharest, Romania – surveillance data and clinical characteristics of patients with influenza-like illness admitted to a tertiary infectious diseases hospital
Provedor de dados: 55
Autores: Drăgănescu,Anca; Săndulescu,Oana; Florea,Dragoş; Vlaicu,Ovidiu; Streinu-Cercel,Anca; Oţelea,Dan; Aramă,Victoria; Luminos,Monica Luminiţa; Streinu-Cercel,Adrian; Niţescu,Maria; Ivanciuc,Alina; Bacruban,Rodica; Piţigoi,Daniela.
ABSTRACT  Background: Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage.  Objectives: To describe the influenza cases and viral circulation among hospitalized patients.  Methods: A prospective study based on active surveillance of inpatients with influenza-like illness from a tertiary hospital in Bucharest, Romania, in the season 2016/17.  Results: A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3–13 years and &gt;65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: A viruses were replaced by B viruses from week 9/2017; B viruses...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: A/H3; B/Victoria; ILI; Influenza; SARI; Subtype.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500377

The investigation of parvovirus B19 infection in patients with haematological disorders by using PCR and ELISA techniques
Provedor de dados: 55
Autores: Us,Tercan; Ozune,Leyla; Kasifoglu,Nilgun; Akgun,Yurdanur.
Parvovirus B19 has a marked tropism for erythroid progenitor cells. This may lead to chronic anemia in predisposed individuals. The purpose of the study was to investigate the frequency of parvovirus B19 infections in patients with diagnosis of haematological disorders. In order to determine the diagnostic use of different markers of parvovirus B19 infection, serum specimens obtained from 79 patients with haematological disorders were tested for specific antibodies and viral DNA through the use of ELISA and PCR techniques. Evidence of parvovirus B19 infection was found in 23/79 (29.1%) patients by demonstrating viral DNA and/or specific IgM antibody. B19 infection was established in 3 of 11 patients with chronic myeloid leukemia, in 3 of 11 acute myeloid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: PCR; ELISA; Haematological disorder.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300006

The NRAMPI, VDR and TNF-α gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility
Provedor de dados: 55
Autores: Merza,Muayad; Farnia,Parissa; Anoosheh,Sabar; Varahram,Mohammed; Kazampour,Mehdi; Pajand,Omid; Saeif,Shima; Mirsaeidi,Mehdi; Masjedi,Mohammad Reza; Velayati,Ali Akbar; Hoffner,Sven.
The natural resistance-associated macrophage protein (NRAMP1), Vitamin-D receptor (VDR) and Tumor necrosis factor (TNF-α) have been associated in susceptibility to tuberculosis, but the results have been inconsistent. This study aimed to determine the association of NRAMP1, VDR, and TNF-á variant with development of pulmonary tuberculosis (PTB) among Iranian patients. The single nucleotide polymorphisms (SNPs) at INT4, D543, 3'UTR of NRAMP1 gene, SNPs in restriction sites of BsmI, and FokI of the VDR gene and SNPs of TNF-α at -238,-308, -244,857,-863 positions were analyzed by PCR-RFLP among two groups of individual; patients with PTB (n=117) and healthy controls (n=60). Thereafter, the frequencies of extended haplotypes and diplotypes were estimated. No...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: NRAMP; VDR; TNF-α gene; Tuberculosis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400002

The organization of Hospital Infection Control Committees and their importance in Brazil
Provedor de dados: 55
Autores: El Far,Fabiane; Marino,Cristiane G. J.; Medeiros,Eduardo Alexandrino Servolo.
The importance of Hospital Infection Control Committees (HICC) increases every year due to the emergence of multiresistant bacterial strains, hospital outbreaks, and other factors that cause HI. This demonstrates the fragility of the quality of hospital and medical care. Having a well-organized HICC benefits hospitals by improving quality, lowering costs and, most important, reducing patient morbidity and mortality. This review records the history of the development of HICCs, their present organizational structure, and offers recommendations for the best methods of infection surveillance.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hospital infection; Prevention; Committee; Control; Costs; Mortality; Surveillance; Quality.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600001

The Place of protease inhibitors in antiretroviral treatment
Provedor de dados: 55
Autores: Tenore,S.B.; Ferreira,P.R.A.
With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Antiretroviral treatment; Protease inhibitors.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012

The prevalence of enteropathy due to Strongyloidiasis in Puerto Maldonado (Peruvian Amazon)
Provedor de dados: 55
Autores: Egido,J. M.; De Diego,J. A.; Penin,P.
Human strongyloidiasis is an important health problem in the southeast region of Peruvian Amazon, due to its prevalence and long term morbidity. An epidemiological study was conducted in the Peruvian Amazon area of Puerto Maldonado to determine the prevalence of strongyloidiasis in the population. Stool samples were collected from 1,133 patients at the outpatient department of our clinic. Strongyloidiasis affected 221 examined patients (20%). Prevalence was highest in males, mostly in children and elderly men. People living in urban and marginal urban areas, those coming from outside the region, and Andean people, showed the highest prevalences. Pre-school children were more likely to be parasitized than older children. The most common symptoms were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Strongyloides stercoralis; Epidemiology; Enteropathy; Peruvian Amazon.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300003

The public health implications of melioidosis
Provedor de dados: 55
Autores: Inglis,Timothy J.J.; Sousa,Anastácio Q.
Melioidosis, which is caused by the bacterium Burkholderia pseudomallei, is a potentially fatal tropical infection, little known outside its main endemic zone of Southeast Asia and northern Australia. Though it has received more attention in recent years on account of its claimed suitability as a biological weapon agent, the principal threat from melioidosis is a result of naturally occurring events. Occasional case clusters, sporadic cases outside the known endemic zone and infections in unusual demographic groups highlight a changing epidemiology. As melioidosis is the result of an environmental encounter and not person-to-person transmission, subtle changes in its epidemiology indicate a role environmental factors, such as man-made disturbances of soil...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Public Health; Melioidosis; Epidemiology.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100013

The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model
Provedor de dados: 55
Autores: Jie,Zhijun; Sun,Wei; Wang,Shanze; Koster,Frederick; Li,Bilan; Harrod,Kevin S.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500580

The role of ERBB2 gene polymorphisms in leprosy susceptibility
Provedor de dados: 55
Autores: Rêgo,Jamile Leão; Oliveira,Joyce Moura; Santana,Nadja de Lima; Machado,Paulo Roberto Lima; Castellucci,Léa Cristina.
Mycobacterium leprae infects skin and peripheral nerves causing deformities and disability. The M. leprae bacterium binds to ErbB2 on the Schwann cell surface causing demyelination and favoring spread of the bacilli and causing nerve injury. Polymorphisms at the ERBB2 gene were previously investigated as genetic risk factors for leprosy in two Brazilian populations but with inconsistent results. Herein we extend the analysis of ERBB2 variants to a third geographically distinct population in Brazil. Our results show that there is no association between the genotyped SNPs and the disease (p &gt; 0.05) in this population. A gene set or pathway analysis under the genomic region of ERBB2 will be necessary to clarify its regulation under M. leprae stimulus.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: ERBB2; Gene analysis; Leprosy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200206

The role of microRNAs in enteroviral infections
Provedor de dados: 55
Autores: Wu,Jing; Shen,Li; Chen,Jianguo; Xu,Huaxi; Mao,Lingxiang.
ABSTRACTThe genus Enterovirus, a member of thePicornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection ofEnterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MicroRNAs; Enterovirus; Infection.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500510

The use of molecular typing to evaluate the dissemination of antimicrobial resistance among gram-negative rods in Brazilian hospitals
Provedor de dados: 55
Autores: Tosin,Iraci; Silbert,Suzane; Sader,Helio S.
Antimicrobial resistance has increased rapidly in Brazil and worldwide during the past few years, giving rise to a growing necessity for antimicrobial resistance surveillance programs. These programs have been instituted in order to monitor bacterial resistance in various regions, and to guide empirical antimicrobial therapy. We evaluated the use of molecular typing in multicenter surveillance programs. We also studied the dissemination modes of selected resistance profiles. Antimicrobial susceptibility to various antimicrobial agents was evaluated by the reference broth microdilution method. Bacterial isolates with selected susceptibility patterns were characterized by pulsed field-gel electrophoresis (PFGE). A total of 119 Gram-negative bacteria were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Molecular typing; Pulsed-field gel electrophoresis; Antimicrobial resistance; Carbapenem-resistant Pseudomonas aeruginosa; Clonal dissemination; Sentinela Program.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600002

The use of monoclonal antibody (Rituximab) in the treatment of type II mixed cryoglobulinemia
Provedor de dados: 55
Autores: Rego,Thiago Carlos Gonçalves; Massumoto,Celso Mitsushi; Batista,Rodrigo Siqueira; Moura,Larissa Hanauer de; Soares,Lygia Maria Costa; Gomes,Andréia Patrícia.
Anti-CD20 monoclonal antibody has been successfully used to treat several self-immune diseases. The authors report the case of a 71 year-old female patient under the use of pegylated form of interferon á associated with ribavirin for the treatment of hepatitis C, who, after concluding the therapeutic program - negative Polymerase Chain Reaction (PCR) - developed a severe cutaneous vasculitis, receiving the diagnostic of type II mixed cryoglobulinemia. Four sessions of plasmapheresis were prescribed along the period of 11 days, with no result. The choice made was to administer anti-CD 20 monoclonal antibody (rituximab), 375 mg/m², per week, during four consecutive weeks. One could observe fast recovery from the purpura, as well as total remission of...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Anti-CD 20 monoclonal; Type II mixed cryoglobulinemia; Hepatitis C; Hodgkin's disease.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100038

The value of public health research and the division between basic vs. applied science
Provedor de dados: 55
Autores: Almeida-Filho,Naomar; Goldbaum,Moisés.
We question the movement towards exclusion of population and social health research from the field of science. The background under analysis is contemporary Brazil, where the scientific field that hosts this kind of research is known as Collective Health. First, the problem is formalized on logical grounds, evaluating the pertinence of considering unscientific the many objects and methods of public health research. Secondly, the cases of pulmonary tuberculosis and external causes are brought in as illustrations of the kind of scientific problem faced in health research today. The logical and epistemological basis of different forms of "scientific segregation" based on biomedical reductionism is analyzed, departing from three theses: (i) the ethics of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Public health; Collective health; Basic sciences; Applied sciences; Science and technology policy; Brazil.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100010

The ﬁrst reported catheter-related Brevibacterium casei bloodstream infection in a child with acute leukemia and review of the literature
Provedor de dados: 55
Autores: Bal,Zumrut Sahbudak; Sen,Semra; Karapinar,Deniz Yilmaz; Aydemir,Sohret; Vardar,Fadil.
Brevibacterium spp. are catalase-positive, non-spore-forming, non motile, aerobic Gram- positive rods that were considered apathogenic until a few reports of infections in immunocompromised patients had been published. To the best of our knowledge, this is the ﬁrst report of B. casei catheter-related bloodstream infection in a child with acute leukemia. We aim to enhance the awareness of pediatric hematology and infectious disease specialists about this pathogen and review of the literature.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Brevibacterium casei; Bloodstream infection Child; Leukemia.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200213

Theories about evolutionary origins of human hepatitis B virus in primates and humans
Provedor de dados: 55
Autores: Souza,Breno Frederico de Carvalho Dominguez; Drexler,Jan Felix; Lima,Renato Santos de; Rosário,Mila de Oliveira Hughes Veiga do; Netto,Eduardo Martins.
Introduction:The human hepatitis B virus causes acute and chronic hepatitis and is considered one of the most serious human health issues by the World Health Organization, causing thousands of deaths per year. There are similar viruses belonging to the Hepadnaviridae family that infect non-human primates and other mammals as well as some birds. The majority of non-human primate virus isolates were phylogenetically close to the human hepatitis B virus, but like the human genotypes, the origins of these viruses remain controversial. However, there is a possibility that human hepatitis B virus originated in primates. Knowing whether these viruses might be common to humans and primates is crucial in order to reduce the risk to humans.Objective:To review the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B virus; Hepadnaviridae; Non-human primates; Evolutionary origins.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500535

Therapeutic approach to acute hepatitis C
Provedor de dados: 55
Autores: Angerami,Rodrigo Nogueira; Gonçales Júnior,Fernando Lopes.
Tipo: Info:eu-repo/semantics/article
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600002

Therapeutic effectiveness of biosimilar standard interferon versus pegylated interferon for chronic hepatitis C genotypes 2 or 3
Provedor de dados: 55
Autores: Vigani,Aline Gonzalez; Gonçales,Eduardo Sellan; Pavan,Maria Helena Postal; Genari,Flavia; Tozzo,Raquel; Lazarini,Maria Silvia Kroll; Fais,Viviane; Feltrin,Adriana; Gonçales,Neiva Sellan; Gonçales Jr,Fernando Lopes.
BACKGROUND: Pegylated interferon (Peg-IFN) and standard interferon (IFN) play a significant role in the treatment of hepatitis C virus (HCV) infection. Biosimilar standard IFN is widely available in Brazil for the treatment of HCV infection genotypes 2 or 3, but its efficacy compared to Peg-IFN is unknown. OBJECTIVE: To compare the sustained virological response (SVR) rates following treatment with biosimilar standard IFN plus ribavirin (RBV) versus Peg-IFN plus RBV in patients with HCV genotypes 2 or 3 infection. METHODS: A retrospective cohort study was conducted in patients with HCV genotypes 2 or 3 infection treated with biosimilar standard IFN plus RBV or with Peg-IFN plus RBV. SVR rates of the two treatments were compared. RESULTS: From January 2005...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferons; Hepatitis C; Treatment outcome.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300003

Therapeutic effects of blood purification in treatment of fulminant hepatic failure
Provedor de dados: 55
Autores: Pu,Yunchuan; Yang,Daokun; Mao,Yanqun; Zhang,Ying; Chen,Kaihong.
OBJECTIVES: To evaluate the clinical effects of blood purification for treating fulminant hepatic failure (FHF). METHODS: Thirty-three severe FHF patients with hepatic encephalopathy (HE) above grade III were subjected to a combined blood purification treatment in addition to the comprehensive liver protection therapy. Patients underwent continuous hemofiltration on a daily basis during the daytime followed by sequential treatment with plasma exchange or hemodialysis every 2-3 days. The therapeutic effects of this treatment were evaluated. RESULTS: After treatment with blood purification, restoration of consciousness (those who abandoned the treatment without restoration of consciousness were excluded) was achieved in 6 of 8 cases (75%) in acute liver...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Liver failure; Hepatic encephalopathy; Blood purification; Therapy.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400007

Therapeutic effects of compound hypertonic saline on rats with sepsis
Provedor de dados: 55
Autores: Dong,Fang; Chen,Wei; Xu,Liang; Wang,Huabing; Lu,Huizhi.
Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique. Several studies have shown that hypertonic saline applied in hemorrhagic shock can rapidly increase the plasma osmotic pressure, facilitate the rapid return of interstitial fluid into the blood vessels, and restore the effective circulating blood volume. Here, we established a rat model of sepsis by using the cecal ligation and puncture approach. We found that intravenous injection of hypertonic saline dextran (7.5% NaCl/6% dextran) after cecal ligation and puncture can improve circulatory failure at the onset of sepsis. We found that the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sepsis; Cecal ligation and puncture; Immune regulation; Lung injury.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500518

Therapeutic impact of CT-guided percutaneous catheter drainage in treatment of deep tissue abscesses
Provedor de dados: 55
Autores: Asai,Nobuhiro; Ohkuni,Yoshihiro; Yamazaki,Ikuo; Kaneko,Norihiro; Aoshima,Masahiro; Kawamura,Yasutaka.
Combination therapy of CT-guided percutaneous drainage and antibiotics is the first-line treatment for abscesses. Its effectiveness has been demonstrated. However, the therapeutic impact of this procedure for infection treatment has never been reported. We retrospectively analyzed all 47 patients who received CT-guided percutaneous drainage for infection treatment. Patients' characteristics, pathogens isolated, antibiotics administered, technical and clinical outcomes, complications related to this procedure and therapeutic impacts were investigated. Patients were 26 males and 21 females. The mean age was 63.5 years (±18.7). The diseases targeted were 19 retroperitoneal abscesses, 18 intraabdominal abscesses, three pelvic abscesses, and seven others. As...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: CT-guided percutaneous drainage; Infection; Abscess.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400015

Therapeutic perspectives for hepatitis C
Provedor de dados: 55
Autores: Araújo,Evaldo Stanislau Affonso de; Barone,Antonio Alci; Pawlotsky,Jean-Michel.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700022

Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
Provedor de dados: 55
Autores: Lopes,Edmundo P.A.; Valente,Lucila M.; Silva,A. Eduardo B.; Kirsztajn,Gianna Mastroianni; Cruz,Cibele N.; Ferraz,Maria Lucia G.
We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Glomerulonephritis; Hepatitis C; Interferon; Ribavirin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500011

Therapy with radio-attenuated vaccine in experimental murine visceral leishmaniasis showed enhanced T cell and inducible nitric oxide synthase levels, suppressed tumor growth factor-beta production with higher expression of some signaling molecules
Provedor de dados: 55
Autores: Datta,Sanchita; Roy,Syamal; Manna,Madhumita.
Background:Visceral leishmaniasis (VL) or Kala-Azar (KA) is one of the most deadly forms of disease among all neglected tropical diseases. There are no satisfactory drugs or vaccine candidates available for this dreaded disease. Our previous studies showed promising therapeutic and prophylactic efficacy of the live, radio-attenuated parasites through intramuscular (I.M.) and intraperitoneal (I.P.) route in BALB/c mice model.Methods:The T-cell proliferation level, the mRNA expression level of inducible nitric oxide synthase (iNOS) and tumor growth factor-beta (TGF-β) genes and finally the phosphorylation levels of phosphoinositide dependent kinase 1 (PDK1), phosphoinositide 3 kinase (PI3K) and p38 mitogen activated protein kinase (p38MAPK) molecules were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Radio-attenuated Leishmania; Parasites; PDK1; PI3K; P38MAPK.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100036

Thermotolerance of Histoplasma capsulatum at 40 °C predominates among clinical isolates from different Latin American regions
Provedor de dados: 55
Autores: Sahaza,Jorge H.; Rodríguez-Arellanez,Gabriela; Canteros,Cristina E.; Reyes-Montes,María del Rocío; Taylor,Maria Lucia.
ABSTRACT The yeast phase of 22 Histoplasma capsulatum clinical isolates from Mexico, Argentina, Colombia, and Guatemala and three reference strains, one from Panama and two from the United States of America (USA), were screened for thermosensitivity characteristics using different analyses. Growth curves at 0, 3, 6, 12, 24, and 30 h of incubation at 37 and 40 °C, the growth inhibition percentage at 40 °C, and the doubling time at 37 and 40 °C were determined for all yeasts studied. Most of the isolates examined exhibited thermotolerant phenotypes at 40 °C, whereas a thermosensitive phenotype at 40 °C was only detected in the Downs reference strain from the USA. Growth inhibition values lower than 33.8% supported the predominance of the thermotolerant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Latin America; H. capsulatum; Yeasts; Thermotolerance; Thermosensitivity.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100044

Thoracic actinomycosis: report of a patient with advanced-stage disease
Provedor de dados: 55
Autores: Santos,José Wellington Alves dos; Zambenedetti,Ricardo Morgental; Mann,Keli Cristina; Cibin,Luiz Fenando Ximenes.
The authors describe a case of advanced thoracic actinomycosis. A 44-year-old man with previous episodes of productive cough with purulent sputum, fever, chest pain and subcutaneous nodules on the left hemithorax was admitted with complaints of lumbar pain irradiating into left lower limb and presence of mass lesion on the left lumbar region. Imaging evaluations were obtained and the patient underwent left lower lobectomy. Histopathology, microscopic examination and anaerobic culture of the resected material diagnosed thoracic actinomycosis.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Actinomycosis; Thoracic; Advanced.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100032

Three decades of meningococcal disease in the State of Santa Catarina, Brazil
Provedor de dados: 55
Autores: Puricelli,Rubens C. B.; Kupek,Emil; Westrupp,Maria Helena Bittencourt.
Consolidation of data on meningococcal disease surveillance for the state of Santa Catarina, Brazil, has provided new insight about the evolution of this disease during the period of 1971-2000. A descriptive epidemiological study, based on retrospective analysis of all cases of meningococcal disease notified in the state of Santa Catarina, linked the surveillance data from the Secretary of the State of Health, magnetic tape records and the data from the national surveillance of diseases of obligatory notification. Following World Health Organization guidelines, cumulative incidence exceeding five cases per 100,000 inhabitants was considered indicative of an epidemic. Official population data from the Fundação Instituto Brasileiro de Geografia e Estatística...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meningitis; Meningococcal disease; Surveillance; Vaccination; Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300008

Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy
Provedor de dados: 55
Autores: Andrade,Luis Jesuino de Oliveira; Atta,Ajax Mercês; Atta,Maria Luiza Brito de Sousa; Mangabeira,Célia Neder Kalil; Paraná,Raymundo.
OBJECTIVE: To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN: Prospective study. PATIENTS AND METHODS: We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were systematically tested at entry (m0), week 12 (m3) and week 24 (m6) of treatment. RESULTS: Mean age of the 65 patients (38 females and 27 males) was 49.61 ± 11.83 years. Seven (10.76%) patients presented baseline thyroid disorders (m0), three had thyroid dysfunction, and four were TPO-Ab positive. Thyroid disorders occurred in the first 12 weeks of treatment in 11...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hepatitis C; Interferon-alpha; Ribavirin; Thyroid diseases; Autoimmunity.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400013

Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin: a review
Provedor de dados: 55
Autores: Andrade,Luis Jesuíno de Oliveira; Atta,Ajax Mercês; D'Almeida Junior,Argemiro; Paraná,Raymundo.
Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid dysfunction may also be a side effect of interferon-based treatment. The principal risk factor for developing thyroid disease in the course of antiviral therapy is the previous positivity for anti-thyroid antibodies (anti-thyroid peroxidase) especially in older women. Screening for autoantibodies and serum thyroid-stimulating hormone is recommended before, during...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Interferon-alpha; Ribavirin; Thyroid dysfunction; Thyroiditis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200009

Thyroid dysfunction in Turkish patients with chronic hepatitis C receiving peginterferon plus ribavirin in the period of 2005-2010
Provedor de dados: 55
Autores: Barut,Sener; Gunal,Ozgur; Erkorkmaz,Unal; Yildiz,Feyza.
Interferon-α based therapy for chronic hepatitis C (CHC) is associated with thyroiditis and thyroid dysfunction (TD). This study investigated whether TD during pegylated interferon-a (PEG-IFN) plus ribavirin treatment favors sustained viral response (SVR), and also the association between TD and PEG-IFN formulations. This retrospective study was performed in CHC patients who had received PEG-IFN plus ribavirin and had been followed for six months after treatment. Several factors were compared between patients with and without TD. 119 patients were included in the study. De novo incidence of TD was found to be 16.8%, and 16 of the 18 patients with TD achieved SVR. Although this rate was higher than patients without TD according to univariate analysis,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Peginterferon; Thyroid dysfunction; Sustained virologic response.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000500008

Time of catheter removal in candidemia and mortality
Provedor de dados: 55
Autores: Nucci,Marcio; Braga,Paula Rocha; Nouér,Simone A.; Anaissie,Elias.
ABSTRACT  Background: The impact of central venous catheter (CVC) removal on the outcome of patients with candidemia is controversial, with studies reporting discrepant results depending on the time of CVC removal (early or any time during the course of candidemia).  Objective: Evaluate the effect of time to CVC removal, early (within 48 h from the diagnosis of candidemia) vs. removal at any time during the course of candidemia, on the 30-day mortality.  Methods: Retrospective cohort study of 285 patients with candidemia analyzing CVC removal within 48 h (first analysis) or at any time (second analysis).  Results: A CVC was in place in 212 patients and was removed in 148 (69.8%), either early (88 patients, 41.5%) or late (60 patients, 28.3%). Overall, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidemia; Central venous catheter; Mortality; Multivariate analysis; Candida.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600455

TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
Provedor de dados: 55
Autores: Mukherjee,Suprabhat; Karmakar,Subhajit; Babu,Santi Prasad Sinha.
Abstract During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection. Hitherto Toll-like receptors (TLRs), especially the surface ones viz. TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens. These pattern recognition receptors (PRRs) not only act as innate sensor but also shape and bridge innate and adaptive immune responses. In addition, they also play a pivotal role in regulating the balance between Th1 and Th2 type of response...
Palavras-chave: Toll like receptor (TLR); Trypanosomiasis; Malaria; Filariasis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200193

TNF -308G &gt; a promoter polymorphism (rs1800629) and outcome from critical illness
Provedor de dados: 55
Autores: Paskulin,Diego D'Ávila; Fallavena,Paulo RV; Paludo,Francis JO; Borges,Thiago J; Picanço,Juliane B; Dias,Fernando S; Alho,Clarice Sampaio.
BACKGROUND: The susceptibility to adverse outcome from critical illness (occurrence of sepsis, septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. An over expression of tumor necrosis factor alpha (TNF-α) can lead to the progression of the inflammatory condition. OBJECTIVE: We assessed the relationship of the genotype distribution of -308G &gt;A TNF-α polymorphism with regard to the development of sepsis, septic shock, higher organ dysfunction or mortality in critically ill patients. METHODS: Observational, hospital-based cohort study of 520 critically ill Caucasian patients from southern Brazil admitted to the general ICU of São Lucas Hospital, Porto Alegre, Brazil. Patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polymorphism; Single nucleotide tumor necrosis factor receptor associated peptides and proteins critical care.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300009

To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
Provedor de dados: 55
Autores: Hajiaghamohammadi,Ali Akbar; Zargar,Ali; Oveisi,Sonia; Samimi,Rasoul; Reisian,Sedigheh.
ABSTRACT  Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.  Methods: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.  Results: Mean ages and SD were 38.8...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Helicobacter pylori; Licorice; Dyspepsia; Peptic ulcer.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600534

Top 10 evidence-based recommendations from the Brazilian Society of Infectious Diseases for the Choosing Wisely Project
Provedor de dados: 55
Autores: Pasqualotto,Alessandro C.; Almeida,Camila S.; Kliemann,Dimas A.; Barcellos,Guilherme B.; Queiroz-Telles,Flávio; Abdala,Edson; Resende,Mariangela; Batista,Filipe P.; Vidal,José E.; Rocha,Jaime; Raboni,Sonia M.; Cimerman,Sergio; Gales,Ana C.
ABSTRACT The Choosing Wisely Initiative aims to collect statements from medical societies all over the world on medical interventions that result in no benefit to patients, with the potential to cause harm. In this article we present the views of the Diagnostic Laboratory Group at the Brazilian Society of Infectious Diseases (SBI). Ten experts from SBI were asked to list 10 diagnostic tests that were perceived as unnecessary in the field of infectious diseases. After voting for the more relevant topics, a questionnaire was sent to all SBI members, in order to select for the most important items. A total of 482 votes were obtained, and the top 10 results are shown in this manuscript. The Choosing Wisely statements of SBI should facilitate clinical practice...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Choosing wisely; Quality; Safety; Infectious diseases; Microbiology; Diagnostic tests; Healthcare administration.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500331

Total abdominal aortic occlusion: a complication of brucellosis
Provedor de dados: 55
Autores: Korkut,Cafer; Sengoz,Gonul; Bilgi,Esra.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300328

Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa
Provedor de dados: 55
Autores: Ilboudo,Denise; Simpore,Jacques; Ouermi,Djeneba; Bisseye,Cyrille; Sagna,Tani; Odolini,Silvia; Buelli,Fabio; Pietra,Virginio; Pignatelli,Salvatore; Gnoula,Charlemagne; Nikiema,Jean-Baptiste; Musumeci,Salvatore.
The coinfection of HIV and hepatitis B virus (HBV) and their vertical transmission constitute a public health problem in sub-Saharan countries of Africa. The objectives of this research are: i) identify the pregnant women that are coinfected by HIV and HBV at Saint Camille Medical Centre; ii) use three antiretroviral drugs (zidovudine, nevirapine and lamivudine) to interrupt the vertical transmission of HIV and HBV from infected mothers; and iii) use the PCR technique to diagnose children who are vertically infected by these viruses in order to offer them an early medical assistance. At Saint Camille Medical Centre, 115 pregnant women, aged from 19 to 41 years, were diagnosed as HIV-positive and, among them, 14 coinfected with HBV. They had at least 32...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnant women; HIV; HBV; MTCT; Lamivudine; HAART; Burkina Faso.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300004

Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Fernandes,Márcia Antunes; Batista,Giovanni Inácio; Carlos,Juliano da Costa Silveira; Gomes,Ivete Martins; Azevedo,Kátia Martins Lopes de; Setúbal,Sérgio; Oliveira,Solange Artimos de; Velarde,Luis Guilhermo Coca; Cardoso,Claudete Aparecida Araújo.
OBJECTIVE: Compare the anti-T. gondii IgG titer between HIV-1 infected and non HIV-1 infected pregnant women and report three cases of congenital toxoplasmosis resulting from reactivation of infection during pregnancy of HIV-1 infected women. METHODS: This study was conducted among 2,270 pregnant women with chronic Toxoplasma gondii infection (absence of IgM and presence of IgG), including 82 HIV-1 infected and 2,188 non-infected women. RESULTS: The average anti-T. gondii IgG titer was 127 for the 2,188 non-HIV-1 infected women, and 227 for the 82 HIV-1-infected women (p = 0,007). These results suggested that higher anti-T. gondii IgG titers in HIV-1-infected pregnant women may not be indicative of an elevated risk for fetal infection. In this study three...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasma Toxoplasmosis; Congenital HIV infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200011

Toxoplasma gondii infection in pregnancy
Provedor de dados: 55
Autores: Lopes,Fabiana Maria Ruiz; Gonçalves,Daniela Dib; Mitsuka-Breganó,Regina; Freire,Roberta Lemos; Navarro,Italmar Teodorico.
Toxoplasmosis is caused by an intracellular protozoan, Toxoplasma gondii, which has a wide geographical distribution. The main infection routes are ingestion of cysts from raw or badly-cooked meat, ingestion of oocysts from substrates contaminated with the feces of infected felines and congenital transmission by tachyzoites. The congenital form results in a severe systemic disease, because if the mother is infected for the first time during gestation, she can present a temporary parasitemia that will infect the fetus. Many of the clinical symptoms are seen in congenitally-infected children, from a mild disease to serious signs, such as mental retardation. Early diagnosis during the pregnancy is highly desirable, allowing prompt intervention in cases of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Toxoplasma gondii; Congenital transmission; Pregnant women.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500011

Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child
Provedor de dados: 55
Autores: Nogueira,Susie Andries; Guedes,Ana Lúcia; Machado,Elizabeth S.; Matos,Juliana A.; Costa,Tomás P.; Cortes,Ely M.; Lambert,John S.
This report describes a case of Toxoplasma encephalitis during pregnancy of an HIV infected woman who was severely immunosuppressed (CD4: 17 cells/mm3), had a high viral load (RNA PCR:230,000 copies/ml), was treated with sulfadiazine, pyrimethamine and folinic acid for toxoplasmosis and was being treated with highly potent antiretroviral drugs (AZT, 3TC and nelfinavir) for HIV infection. The newborn was born through an elective C-section, received six weeks of AZT according to the 076 protocol and was clinically normal at birth. Subsequently he had two RNA PCR negatives for HIV, seroreverted and had no clinical or laboratory evidence of congenital toxoplasmosis. Despite the concerns of the use of these combined therapies on the foetus during pregnancy,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasma encephalitis; Pregnancy; HIV/AIDS; Prevention of vertical transmission.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400008

Toxoplasmic encephalitis: role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome
Provedor de dados: 55
Autores: Rodrigues,Maria de Lourdes; Deghaide,Neifi Hassam; Figueiredo,José Fernando; de Menezes,Marcelo Bezerra; Demarco,Ana Lúcia; Donadi,Eduardo; Fernandes,Ana Paula.
Abstract  Background/aims The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndrome with and without Toxoplasmic Encephalitis.  Methods 114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephalitis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied.  Results Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HLA; AIDS; Encephalitis; T. gondii.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200115

Transfusion risk for hepatitis B, hepatitis C and HIV in the state of Santa Catarina, Brazil, 1991-2001
Provedor de dados: 55
Autores: Kupek,Emil.
We examined the time trend of residual risk of transfusing blood contaminated with HIV, hepatitis B and hepatitis C, in the largest blood bank of the state of Santa Catarina, Brazil, 1991-2001. The HIV risk was reduced approximately 10 times during the decade of 1990, to 1:48777, but then increased significantly by the end of 2001. A similar time trend was observed for hepatitis B and hepatitis C, although the increase was not significant in this case. Even during the period of lowest risk, the estimates were considerably higher than in developed countries.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood transfusion; HIV; Hepatitis B; Hepatitis C.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300007

Transgenic lettuce seedlings carrying hepatitis B virus antigen HBsAg
Provedor de dados: 55
Autores: Marcondes,Jackson; Hansen,Ekkehard.
The obtainment of transgenic edible plants carrying recombinant antigens is a desired issue in search for economic alternatives viewing vaccine production. Here we report a strategy for genetic transformation of lettuce plants (Lactuca sativa L.) using the surface antigen HBsAg of hepatitis B virus. Transgenic lettuce seedlings were obtained through the application of a regulated balance of plant growth regulators. Genetic transformation process was acquired by cocultivation of cotyledons with Agrobacterium tumefaciens harboring the recombinant plasmid. It is the first description of a lettuce Brazilian variety "Vitória de Verão" genetically modified.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Edible vaccine; Hepatitis B; Oral immunization; Recombinant antigen; Transgenic plants.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600004

Transitioning through AIDS epidemics - gender and temporality
Provedor de dados: 55
Autores: Pinto,Clarice Souza; Fernandes,Carlos Eurico dos Santos; Oliveira,Roberto Dias de; Matos,Vanessa Terezinha Gubert de; Castro,Ana Rita Coimbra Motta de.
ABSTRACT  OBJECTIVE:  To understand the evolution of AIDS over time in Mato Grosso do Sul, Brazil, using incidence, lethality, and mortality coefficients.  METHODS:  A descriptive epidemiological study based on time series analysis of secondary data from the Notifiable Diseases Information System reported between 1985 and 2012.  RESULTS:  The prevalence of AIDS was higher among men, with evidence of feminization during the first 14 years of the epidemic. There was no statistically significant sex difference in AIDS lethality. Women were 1.3 times more likely to survive than men.  CONCLUSIONS:  Gender differences must be considered when designing new HIV/AIDS prevention strategies.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Aids; Mortality; Lethality; Incidence.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600657

Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review
Provedor de dados: 55
Autores: Rosso,Fernando; Pineda,Juan C.; Sanz,Ana M.; Cedano,Jorge A.; Caicedo,Luis A.
ABSTRACT Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients had positive serology and RT-PCR. Infection in donors was detected through serology. All cases presented with fever within the first week after transplantation. There were no fatal cases. After these cases, we implemented dengue screening with NS1 antigen detection in donors during dengue outbreaks, and no new cases were detected. In...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Dengue virus; Transmission; Solid organ transplantation; Screening.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100063

Transmission of scabies in a rural community
Provedor de dados: 55
Autores: Jackson,Anne; Heukelbach,Jorg; Feldmeier,Hermann.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400001

Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
Provedor de dados: 55
Autores: Ferreira,Ana Cristina G.; Coelho,Lara E.; Grinsztejn,Eduarda; Jesus,Carlos S. de; Guimarães,Monick L.; Veloso,Valdiléa G.; Grinsztejn,Beatriz; Cardoso,Sandra W.
Abstract  Introduction: The widespread use of antiretroviral therapy increased the transmission of antiretroviral resistant HIV strains. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Transmitted drug resistance may jeopardize the early goals of early antiretroviral treatment among acute/recent HIV infected patients.  Methods: Patients with acute/recent HIV infection who underwent resistance test before antiretroviral treatment initiation were included in this analysis. HIV-1 sequences were obtained using an in house protease/reverse transcriptase genotyping assay. Transmitted drug resistance was identified according to the Stanford HIV Database for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Infection; Transmission; Primary resistance; Antiretroviral therapy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400396

Transverse myelitis associated to HCV infection
Provedor de dados: 55
Autores: De Carli,Diego Michelon; Pannebeker,Jeferson; Pedro,Fábio Lopes; Haygert,Carlos Jesus Pereira; Hertz,Everaldo; Beck,Maristela de Oliveira.
Tipo: Info:eu-repo/semantics/report
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200015

Transverse myelitis caused by varicella zoster: case reports
Provedor de dados: 55
Autores: Yýlmaz,Sema; Köseoðlu,Hamide Kart; Yücel,Eftal.
Transverse myelitis is a group of disorders characterized by focal inflammation of the spinal cord and results in loss of motor and sensory function below the level of injury. Occurrence of this condition during or following varicella infection is uncommon. This report describes two cases of transverse myelitis caused by varicella zoster.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Varicella zoster; Infection; Transverse myelitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100040

Treatment of adults with community-acquired respiratory tract infections: results of a multicentric clinical trial with gatifloxacin
Provedor de dados: 55
Autores: Medeiros,Eduardo Alexandrino Servolo.
Respiratory tract infections have an important clinical and economic impact and they are the most common indication for antibiotic use in outpatient practice. This prospective, multicenter non-controlled trial assessed the efficacy and safety of gatifloxacin in the treatment of community-acquired respiratory tract infections. Patients were treated with a daily oral dose of gatifloxacin 400 mg for 7-14 days. The diagnosis of respiratory infection was made based on the clinical condition and/or radiologic findings. A total of 5,044 adult patients with community-acquired respiratory infections was treated with gatifloxacin in different centers in Brazil between March 1, 2001, and October 31, 2001. Among the 5,044 patients treated, 1,501 patients (29.76%) had...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gatifloxacin; Community-acquired pneumonia; Acute sinusitis; Acute exacerbation of chronic bronchitis; Treatment of respiratory infections.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400001

Treatment of B Non-Hodgkin's Lymphoma in children: the experience of multicentre studies and Brazilian National Cancer Institute's experience
Provedor de dados: 55
Autores: Klumb,Claudete.
Tipo: Info:eu-repo/semantics/report
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500030

Treatment of chronic hepatitis C in patients with chronic kidney disease with Sofosbuvir-basead regimes
Provedor de dados: 55
Autores: Rossato,Giovana; Tovo,Cristiane Valle; Almeida,Paulo Roberto Lerias de.
ABSTRACT  Background: To analyze the effectiveness and the safety of Sofosbuvir-based regimens to treat patients with chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD).  Methods: A retrospective, observational study in patients with chronic HCV infection and CKD treated with Sofosbuvir-based regimens was performed. Liver fibrosis, comorbidities, HCV genotype and sustained virological resposnse (SVR) at 12th week post-treatment were evaluated. Kidney function was accessed by serum creatinine and glomerular filtration rate (GFR). The assumed level of significance was 5 %.  Results: Thirty-five patients were treated. The mean age was 52.1 ± 10.9 years, 19 (54.3 %) were women, 32 (91.4 %) were already kidney transplanted and 3 (8.6 %)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hemodialysis; Kidney transplantion; Direct-acting antiviral; Sofosbuvir; Daclatasvir.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100025

Treatment of chronic hepatitis C in treatment-naïve patients
Provedor de dados: 55
Autores: Ferreira,Marcelo Simão.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700015

Treatment of chronic hepatitis C virus infection among Brazilian haemophiliacs
Provedor de dados: 55
Autores: Pereira,Graziella Hanna; Mangini,Cláudia.
Chronic hepatitis C virus (HCV) infection is now the most important cause of liver cirrhosis and hepatocellular carcinoma worldwide. HCV infection prevalence is high among haemophiliacs (39%-98%), who got infected when received inadequately or non-virus-inactivated large-pool clotting factors concentrates before 1992. Current treatment reduces the probability of developing advanced stages of liver disease. The objective of this study was to evaluate efficacy and safety of the treatment with interferon alpha (IFN) and ribavirin in haemophiliacs. From July 2000 to November 2002, 18 patients were treated with IFN, three million units thrice weekly combined with daily oral doses of 1,000 or 1,250 mg of ribavirin for a minimum of 48 weeks. Eleven patients (61%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis C; Haemophilia; Interferon alpha; Ribavirin therapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100006

Treatment of genotype one hepatitis C virus (HCV) infection in HIV co-infected patients using telaprevir based regimen
Provedor de dados: 55
Autores: Siraj,Dawd S.; Kabchi,Badih; Ashraf,Muhammad S.; Shah,Kaushal; Elnabtity,Manal.
Tipo: Info:eu-repo/semantics/other
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200226

Treatment of human papillomavirus with peg-interferon alfa-2b and ribavirin
Provedor de dados: 55
Autores: Pavan,M.H.P.; Velho,P.E.N.F.; Vigani,A.G.; Gonçalves Jr.,F.L.; Aoki,F.H.
We reported one case of human immunodeficiency virus and hepatitis C virus co-infected patient who presented a significant improvement of human papillomavirus (HPV) lesions during the treatment of chronic hepatitis using peg-interferon alfa-2b and ribavirin.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Human immunodeficiency virus; Human papillomavirus; Pegylated-interferon; Ribavirin.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300017

Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags
Provedor de dados: 55
Autores: Adams,Andréa I.H.; Morimoto,Lucia N.; Meneghini,Leonardo Z.; Bergold,Ana M.
Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2ºC to 8ºC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 ºC and at room temperature, protected from light, was evaluated. These infusion...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antifungal drugs; Voriconazole; Voriconazole stability; Voriconazole infusion solutions; PVC bags.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500011

Treatment of methicillin-resistant Staphylococcus aureus in Latin America
Provedor de dados: 55
Autores: Luna,Carlos M; Rodríguez-Noriega,Eduardo; Bavestrello,Luis; Gotuzzo,Eduardo.
The global spread of methicillin-resistant Staphylococcus aureus (MRSA) means it is now a pathogen of worldwide public health concern. Within Latin America, MRSA is highly prevalent, with the proportion of S. aureus isolates that are methicillin-resistant on the rise, yet resources for managing the infection are limited. While several guidelines exist for the treatment of MRSA infections, many are written for the North American or European setting and need adaptation for use in Latin America. In this article, we aim to emphasize the importance of appropriate treatment of MRSA in the healthcare and community settings of Latin America. We present a summary of the available guidelines and antibiotics, and discuss particular considerations for clinicians...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Treatment; Antibiotic therapy; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800007

Treatment of nosocomial pneumonia: an experience with meropenem
Provedor de dados: 55
Autores: Santos,Sigrid S.; Machado,Flavia R; Kiffer,Carlos R. V.; Barone,Antonio A.
This study aimed at evaluating the efficacy and safety of meropenem as first choice treatment for nosocomial pneumonia (NP) in intensive care units (ICU) in Hospital das Clínicas (HC) - University of São Paulo; a hospital with high incidence of antimicrobial resistance. Prospective, open, and non-comparative trial with meropenem were done in patients with ventilator-associated or aspiration NP in 2 ICUs at HC - University of São Paulo. Etiologic investigation was done through bronchoalveolar lavage and blood cultures prior to study entry. Twenty-five (25) critically ill patients with NP were enrolled (mean age 40 years). Ventilator-acquired pneumonia was responsible for 76% of cases and aspiration NP for 24%. Specific etiologic agents were identified and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Meropenem; Nosocomial pneumonia; Intensive care unit.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300004

Treatment of patients infected with hepatitis C virus and presenting extrahepatic manifestations
Provedor de dados: 55
Autores: Tengan1,Fátima Mitiko; Barone,Antonio Alci.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700018

Treatment options in the management of thrombocytopenia in patients infected with HCV
Provedor de dados: 55
Autores: Oliveira,André Cosme de.
Tipo: Info:eu-repo/semantics/other
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000700021

Treatment outcome of human immunodeﬁciency virus and tuberculosis co-infected patients in public hospitals of eastern and southern zone of Tigray region, Ethiopia
Provedor de dados: 55
Autores: Belayneh,Mehretu; Giday,Kalayta; Lemma,Hailemariam.
Background:Tuberculosis is a leading cause of death among people living with human immunodeﬁciency virus. In sub-Saharan Africa, tuberculosis accounts for more than 78% of all deaths among people with human immunodeﬁciency virus.Objectives:To assess tuberculosis treatment outcome and the associated factors in adult tuberculosis/human immunodeﬁciency virus co-infected patients in four public hospitals of eastern and southern zone of Tigray region, Ethiopia.Methodology:Institution based cross-sectional study design was used to examine secondary data from tuberculosis/human immunodeﬁciency virus co-infected patients attending four public hospitals of eastern and southern zone of Tigray, from January 2009 to August 2011. Systematic random sampling technique...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Treatment outcome; TB/HIV co-infected; Tigray; Ethiopia.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100047

Treatment outcome of tuberculosis patients under directly observed treatment in Addis Ababa, Ethiopia
Provedor de dados: 55
Autores: Getahun,Belete; Ameni,Gobena; Medhin,Girmay; Biadgilign,Sibhatu.
BACKGROUND: Tuberculosis is one of the leading causes of mortality among infectious diseases worldwide. For effective tuberculosis control, it is a pre-requisite to detect the cases as early as possible, and to ensure that the tuberculosis patients complete their treatment and get cured. However, in many resource-constrained settings treatment outcome for tuberculosis has not been satisfactory. OBJECTIVE: The aim of the study was to assess the treatment outcome of tuberculosis patients and investigate the association of demographic and clinical factors with treatment success of patients enrolled in Directly Observed Treatment Short Course program in government owned health centers over the course of five consecutive years in Addis Ababa, Ethiopia. METHODS:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Treatment outcome; Tuberculosis DOTS; Ethiopia.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500003

Treatment switch guided by HIV-1 genotyping in Brazil
Provedor de dados: 55
Autores: Tupinambás,Unaí; Ribeiro,Flávia Andrade; Aleixo,Agdemir; Greco,Dirceu.
We assessed the performance of HIV-1 genotyping tests in rescue therapy. Patients were divided into two groups: group 1 (genotyped), included those switching to new antiretroviral drugs based on HIV-1 genotyping data, and group 2 (standard of care -SOC), comprised those in rescue therapy who had not used this test. This was an open and non-randomized study, with 74 patients, followed up for a mean period of 12 months, from February 2002 to May 2003. The groups differed in the duration of antiretroviral use, experience with diverse drug classes (non-nucleoside reverse transcriptase inhibitors and protease inhibitors) and viral load &lt;2.6 log10 copies/mL at any time during treatment. In 23 patients (group 1), the switch in antiretroviral (ARV) regimen was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Genotyping; Antiretroviral resistance testing.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200003

Trends and characteristics of AIDS mortality in the Rio de Janeiro city after the introduction of highly active antiretroviral therapy
Provedor de dados: 55
Autores: Saraceni,Valéria; Cruz,Marly Marques da; Lauria,Lilian de Mello; Durovni,Betina.
We examined the characteristics of AIDS mortality in Rio de Janeiro city from 1995 to 2003. During this period, highly active antiretroviral therapy with protease inhibitors was made available, and it changed the pattern of the epidemics. There was a 47.5% reduction in the number of AIDS deaths within the period, with an increase in the proportion of women among the deceased; their schooling was lower than that of the men, similar to the trends of the national-level epidemics. The main place of death changed from university hospitals to emergency rooms. The proportion of cases reported to the National Diseases Surveillance System (SINAN) reported only through the death certificate remained high. Although there is free distribution of antiretrovirals by the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Mortality; Antiretrovirals.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300003

Trends and predictors of HIV-1 acquired drug resistance in Minas Gerais, Brazil: 2002–2012
Provedor de dados: 55
Autores: Duani,Helena; Aleixo,Agdemir Waleria; Tupinambás,Unaí.
Abstract Several studies show that the prevalence of multidrug-resistant HIV-1 virus is declining over time. A retrospective cohort study was carried out to evaluate the trends of drug resistance in antiretroviral treatment-exposed individuals in a state of a middle-income country, Minas Gerais, southeast region of Brazil. We analyzed 2115 HIV-1 sequences from 2002 up to 2012, from 52 cities of Minas Gerais. The groups were analyzed according to the definitions: "IAS – 3 class mutations", if ≥1 drug resistance mutation from IAS 2015 list (DRM) was present in each class; "No fully susceptible drugs" as the absence of any fully susceptible drug in Stanford algorithm; and "GSS ≥ 2″, when a maximum calculated GSS (genotypic susceptibility score) was ≥2 or ≥3,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Resistance; Genotyping; Epidemiology.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200148

Trends in bacterial resistance in a tertiary university hospital over one decade
Provedor de dados: 55
Autores: Góngora Rubio,Fernando; Oliveira,Viviane Decicera Colombo; Rangel,Regina Mara Custódio; Nogueira,Mara Corrêa Lelles; Almeida,Margarete Teresa Gottardo.
The objective of this study was to investigate bacterial resistance trends, infection sites and the relationship between resistance and admittance to the intensive care unit (ICU). A total of 53,316 bacteria identified between 1999 and 2008 were evaluated. Multidrug resistance was characterized when gram-negative bacilli (GNB) presented resistance to two or more classes of antibiotics. Gram-positive cocci (CPC) were assessed for resistance to penicillin, oxacillin and vancomycin. GNB were the most common (66.1%) isolate. There was a 3.7-fold overall increase in multidrug resistant GNB over the study period; Acinetobacter baumanii and Staphylococcus aureus were the most prevalent. Highest increases were recorded for Kleb siella pneumoniae (14.6-fold) and...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Multiresistance; Bacteria; Trends.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400014

Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis andMycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
Provedor de dados: 55
Autores: Coelho,Lara; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz; Luz,Paula Mendes.
BACKGROUND:The natural history of HIV infection has changed dramatically after the introduction of highly active antiretroviral therapy. Currently, opportunistic illnesses still represent a major cause of death and hospitalization in this population. In this study, we review the trends in opportunistic illnesses incidence rates and compare the results observed in high-income settings with that for low/middle-income settings, with special attention given to studies from Brazil.METHODS:We systematically searched Pubmed, Web of Science, Lilacs and Google scholar for publications on HIV associated opportunistic illness. Studies reporting rates based on person-time for all opportunistic illnesses and/or the three opportunistic infections of interest,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS-related opportunistic infections; Opportunistic infection; Acquired immunodeficiency syndrome; Incidence.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200196

Trichomonas vaginalis and associated factors among women living with HIV/AIDS in Amazonas, Brazil
Provedor de dados: 55
Autores: Silva,Leila Cristina Ferreira; Miranda,Angélica Espinosa; Batalha,Rosieny Santos; Monte,Rossicléia Lins; Talhari,Sinésio.
OBJECTIVES: Our goal was to determine the prevalence of Trichomonas vaginalis and its associated factors among women living with HIV attending an AIDS clinic in Manaus, Amazonas, Brazil. METHODS: Cross-sectional study among women attending an AIDS clinic in Manaus between March and December 2010 for gynecological examination were invited to participate. Enrolled patients answered a face-to-face interview including demographic, behavioral and clinical data. They also underwent a gynecological evaluation and cervical scrape samples were collected for wet mount, Gram stain, culture and cytological analysis. A blood sample was obtained to determine TCD4+ lymphocytes and viral load. RESULTS: A total of 341 (91.2%) women participated in the study. The prevalence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trichomonas vaginalis; HIV; Associated factors; Amazonas.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600012

Trichomonas vaginalis infection among young pregnant women in Brazil
Provedor de dados: 55
Autores: Miranda,Angelica E.; Pinto,Valdir M.; Gaydos,Charlotte A.
Our goal was to determine the prevalence of Trichomonas vaginalis and its associated risk factors in parturient women aged 15–24 years attending Brazilian public maternity units. Participants answered a demographic, behavioral, and clinical data questionnaire. A sample of urine was screened for T. vaginalis. A total 299 women participated in this study. The prevalence rate of T. vaginalis was 7.7% (95% CI: 4.7–10.7%). The factors associated with T. vaginalis were use of illicit drugs OR = 4.70 (95% CI: 1.63–13.56, p = 0.004)] and not attending antenatal care OR = 5.15 (95% CI: 1.15–23.25, p = 0.032)]. These data demonstrate that it is important to discuss how to include routine screening for T. vaginalisduring antenatal care in Brazil.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Trichomonas vaginalis; Pregnancy; Prevalence; Risk factors.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600669

Tropical pruritus
Provedor de dados: 55
Autores: Loulergue,Pierre; Mir,Olivier.
Tipo: Info:eu-repo/semantics/article
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400464

Troponin in Chagas disease
Provedor de dados: 55
Autores: Aras,Roque; Bastos,Claudilson; Mota,Gildo; Sodré,Fábio; Moreira,Agnaluce; Tavares,Armando; Lima,José Carlos.
Tipo: Info:eu-repo/semantics/other
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600001

Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Provedor de dados: 55
Autores: Vieira,Gabriela Alves Licursi; Silva,Marco Túlio Alves da; Regasini,Luis Octávio; Cotinguiba,Fernando; Laure,Helen Julie; Rosa,José César; Furlan,Maysa; Cicarelli,Regina Maria Barretto.
ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosomatids; Proteome; Piplartine; Therapeutic targets.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300208

Tuberculin skin testing in inflammatory bowel disease patients from an endemic area of Brazil
Provedor de dados: 55
Autores: Cardoso,Ingrid Puig; de Almeida,Neogelia Pereira; Gotardo,Daniela Rosa; Cardeal,Mauricio; Santana,Genoile Oliveira.
Objective:Inflammatory bowel disease (IBD) is a chronic disorder involving the gastrointestinal tract. Immunosuppressive drugs are usually prescribed to treat IBD patients, and this treatment can lead to tuberculosis reactivation. This paper aimed to analyze tuberculin skin test (TST) results in IBD patients at a reference center in Brazil.Methods:We evaluated TST results in IBD patients using a cross-sectional study. We also analyzed the medical records of patients treated at a reference IBD outpatient unit where TST is routinely performed.Results:We reviewed 119 medical records of 57 (47.9%) Crohn's disease (CD), 57 (47.9%) ulcerative colitis (UC) and 5 (4.2%) indeterminate colitis (IC) patients. The mean (SD) age was 43.5 (13.7) years old. TST was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: IBD; TST; Latent tuberculosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100060

Tuberculosis: a study of 111 cases in an area of high prevalence in the extreme south of Brazil
Provedor de dados: 55
Autores: Mattos,Ivo Gomes de; Ribeiro,Marta Osório; Netto,Isabel Cristina de O.; d'Azevedo,Pedro Alves.
Tuberculosis is an increasingly important public health problem in developing countries. We studied 111 tuberculosis patients confirmed by mycobacteria isolation between 1998 and 2000 in Rio Grande, in south Brazil. One-hundred-thirteen pulmonary and extrapulmonary clinical materials were examined through culture by the Ogawa-Kudoh method and through smear examination by the Ziehl-Nielsen or Kinyoun methods. The identification of Mycobacterium tuberculosis was done through the usual phenotypical methods. The proportion method (indirect technique) was used to determine the resistance of isolates. The man/woman ratio was 2.6:1, 75% were white, and the group had a mean age of 39.7±12.7. Risk factors were present in 38.7% (34 men and 9 women, p=0.2), with a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Mycobacterium tuberculosis; Resistance.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300008

Tuberculosis and AIDS co-morbidity in Brazil: linkage of the tuberculosis and AIDS databases
Provedor de dados: 55
Autores: Miranda,Angelica Espinosa; Golub,Jonathan E.; Lucena,Francisca de Fátima; Maciel,Ethel Noia; Gurgel,Maria de Fátima; Dietze,Reynaldo.
This study evaluated differences in AIDS patients with and without tuberculosis (TB) in Espírito Santo State, Brazil. Standard regional AIDS (SINAN, SISCEL, SICLOM and SIM) and tuberculosis (SINAN) databases were used. TB and AIDS databases were linked using Reclink software, version 3, with SPSS software support to identify co-infected cases. Data from July 2000 to June 2006 in Espírito Santo State were linked. The results showed 3,523 adult AIDS cases and 9,958 adult TB cases resulted in 430 co-infected patients, who were compared to 1,290 AIDS patients who never developed TB. Among 430 co-infected patients, TB was diagnosed first in 223 (51.9%), AIDS was first in 44 (10.2%), and AIDS and TB were diagnosed concurrently in 163 (37.9%). Median age did not...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Tuberculosis; Co-infection; Secondary data.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200013

Tuberculosis associated with transient hemolytic anemia responsive to tuberculosis chemotherapy: a case report
Provedor de dados: 55
Autores: Safe,Izabella Picinin; O'brien,Connor; Ferreira,Fernando Rogério Lara; Souza,Márcia Lidiane Vasconcelos Dias de; Ramasawmy,Rajendranath.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100021

Tuberculosis contact tracing among children and adolescent referred to children's hospital in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Mendonça,Angela Marcia Cabral; Kritski,Afrânio Lineu; Sant'Anna,Clemax Couto.
Objective: To describe the investigation of latent tuberculosis infection and indication for isoniazid preventive therapy in children and adolescents evaluated at the children's hospital.Methods: This retrospective study examines all latent tuberculosis infection subjects with indication for isoniazid preventive therapy attended during 2002-2009 at the pulmonology outpatient clinic from children's hospital in Rio de Janeiro, Brazil. The subjects were classified into three groups by origin: (G1) primary and secondary health units; (G2) children's hospital-pulmonology outpatient clinic; and (G3) children's hospital-specialty outpatient clinics. The association between the variables examined and G1 was analyzed using uni- variate analysis.Results: Of the 286...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Preventive therapy; Operational research; Pediatric tuberculosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000300296

Tuberculosis in Brazil: last ten years analysis - 2001-2010
Provedor de dados: 55
Autores: Oliveira,Gisele Pinto de; Torrens,Ana Wieczorek; Bartholomay,Patrícia; Barreira,Draurio.
OBJECTIVE: To describe tuberculosis epidemiological situation in Brazil, as well as program performance indicators in 2001-2010 period, and discuss the relationship between changes observed and control measures implemented in this century first decade. METHODS: It is a descriptive study, data source was the Information System for Notifiable Diseases (Sinan), Mortality Information System (SIM), Unified Health System Hospital Information System (SIH/SUS) and TB Multidrug-resistant Surveillance System (MDR-TB/SS). Indicators analyzed were organized into four major groups: TB control program (TCP) coverage and case detection; morbidity; treatment and TCP performance; and mortality. RESULTS: In the years analyzed there was a decrease in the number of new cases...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Epidemiology; Surveillance; Information system; Data quality.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200016

Tuberculosis in HIV-infected infants, children, and adolescents in Latin America
Provedor de dados: 55
Autores: Krauss,Margot R.; Harris,D. Robert; Abreu,Thalita; Ferreira,Fabiana G.; Ruz,Noris Pavia; Worrell,Carol; Hazra,Rohan.
Objective:To evaluate the occurrence, clinical presentations and diagnostic methods for tuberculosis in a cohort of HIV-infected infants, children and adolescents from Latin America.Methods:A retrospective analysis of children with tuberculosis and HIV was performed within a prospective observational cohort study conducted at multiple clinical sites in Latin America.Results:Of 1114 HIV-infected infants, children, and adolescents followed from 2002 to 2011, 69 that could be classiﬁed as having conﬁrmed or presumed tuberculosis were included in this case series; 52.2% (95% CI: 39.8-64.4%) had laboratory-conﬁrmed tuberculosis, 15.9% (95% CI: 8.2-26.7%) had clinically conﬁrmed disease and 31.9% (95% CI: 21.2-44.2%) had presumed tuberculosis. Sixty-six were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis HIV; Children; Latin America.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100023

Tuberculosis incidence among people living with HIV/AIDS with virological failure of antiretroviral therapy in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Rebouças,Monaliza Cardozo; Silva,Márcio Oliveira da; Haguihara,Tatiana; Brites,Carlos; Martins Netto,Eduardo.
Abstract Antiretroviral therapy for HIV has led to increased survival of HIV-infected patients. However, tuberculosis remains the leading opportunistic infection and cause of death among people living with HIV/AIDS. Tuberculosis has been shown to be a good predictor of virological failure in this group. This study aimed to evaluate the incidence of tuberculosis and its consequences among individuals diagnosed with virological failure of HIV. This was a retrospective cohort study involving people living with HIV/AIDS being followed-up in an AIDS reference center in Salvador, Bahia, Brazil. Individuals older than 18 years with HIV infection on antiretroviral therapy for at least six months, diagnosed with virological failure (HIV-RNA greater than or equal to...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Tuberculosis; Virological failure; HIV infection.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500562

Tuberculosis of the cystic duct lymph node
Provedor de dados: 55
Autores: Melo,Valdinaldo Aragão de; Melo,Gustavo Barreto de; Silva,Renata Lemos; Piva,Nestor; Almeida,Maria Luiza Dória.
Tuberculosis of the cystic duct lymph node associated with cholelithiasis is rare. We report a case of a 40 year-old woman with this pathology. She presented with anorexia, biliary colic, postprandial fullness and fever. Imaging studies revealed cholelithiasis and several visible portal lymph nodes. Cholecystectomy was performed and histopathological examination showed tuberculosis of the cystic duct lymph node without affecting the gallbladder. The presence of gallstones and lymphadenopathy in computed tomography, associated with persistent fever and symptoms that resemble cholecystitis, should cause suspicion of tuberculosis. However, diagnosis is usually achieved by microscopic appearance of caseating granulomas and isolation of Mycobacterium...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cystic duct; Lymph node; Tuberculosis; Gallstone.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100009

Tuberculosis research meeting in Bahia
Provedor de dados: 55
Autores: Netto,Eduardo Martins.
Tipo: Info:eu-repo/semantics/article
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200001

Tuberculosis treatment outcome and associated factors among smear-positive pulmonary tuberculosis patients in Afar, Eastern Ethiopia: a retrospective study
Provedor de dados: 55
Autores: Zenebe,Tizazu; Tefera,Ermias.
ABSTRACT Evaluating the outcomes of tuberculosis treatment and understanding the specific reasons for unfavorable treatment outcome are important in evaluating the effectiveness of tuberculosis control program. A retrospective study was conducted to assess tuberculosis treatment outcomes and associated factors among smear positive pulmonary tuberculosis patients in zone-one health facilities of Afar regional state, Ethiopia. A total of 380 smear positive pulmonary tuberculosis patients’ registration book recorded with complete information from Jan 2011 to Dec 2013 were analyzed. Of 380 patients included in the analysis, 238 were male and 142 female with mean age of 30.7. Overall treatment outcome were 128 (33.7%) cured, 192 (50.2%) completed, 17 (4.5%)...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Tuberculosis; Treatment outcome; Smear positive pulmonary TB; Ethiopia.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600635

Tuberculous otomastoiditis complicated by sinus vein thrombosis
Provedor de dados: 55
Autores: Bal,Zumrut Sahbudak; Sen,Semra; Yildiz,Katibe Basak; Ciftdogan,Dilek Yilmaz; Vardar,Fadil.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600024

Tularemia and the oculoglandular syndrome of Parinaud
Provedor de dados: 55
Autores: Altuntas,Emine Elif; Polat,Kerem; Durmus,Kasim; Uysal,Ismail Önder; Müderris,Suphi.
An 18-year-old female came to our clinic with complaints of a tender lump just under her jaw on the left side and another lump in front of her left ear, ecchymosis around the eye and some redness in the eye at the same side. After administering antibiotic therapy for two days we suspected of tularemia and referred the patient to the Infectious Diseases Department. A serum sample was taken and a fine needle aspiration biopsy was performed. The patient was diagnosed with tularemia, the oculoglandular syndrome of Parinaud. Tularemia should also be kept in mind for differential diagnosis in patients with both ocular and glandular symptoms in endemic regions like Turkey and the appropriate therapy should be initiated immediately.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Tularemia; Rare diseases; Parotitis.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100017

Tumoural form of Whipple's disease simulating carcinomatosis
Provedor de dados: 55
Autores: Costa,Jamille Hemétrio Salles Martins; Maciel,Aline Bussinger; Godinho,Matheus de Navarro Guimarães; Paula,Rafaela Brito de; Gotardelo,Daniel Riani.
Whipple's disease is a rare disease caused by the actinomycete bacteria Tropheryma whipplei, which cause intestinal infection. The most common symptoms are chronic diarrhoea, weight loss, abdominal pain, arthritis and neurological abnormalities, which can be fatal. This paper reports a case of a 57-year-old Brazilian woman with diarrhoea, vomiting, abdominal pain, appetite loss, intermittent fever, malaise, weight loss and malnutrition. Migratory polyarthralgia and recurrent visual scotomas preceded the symptoms. The retroperitoneal pseudotumour formation finding was associated with prolonged wasting syndrome, which did not respond to usual therapies, thus leading to the investigation of carcinomatosis disease. After laparotomy, biopsy and histochemical...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Whipple's disease; Tropheryma whipplei; Carcinomatosis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300346

Tungiasis in a Colombian patient
Provedor de dados: 55
Autores: Díaz,Claudia J.; Escandón-Vargas,Kevin.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400484

Two cases of mother-to-child transmission of HIV and Trypanosoma cruzi in Argentina
Provedor de dados: 55
Autores: Agosti,Maria Rosa; Ercoli,Pablo; Dolcini,Guillermina; Andreani,Guadalupe; Martínez Peralta,Liliana; González Ayala,Silvia.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400018

Two cases of pulmonary and pleural sparganosis confirmed by tissue biopsy and immunoserology
Provedor de dados: 55
Autores: Chung,Sang Wan; Kim,Yee Hyung; Lee,Eun Jung; Kim,Dae Hyun; Kim,Gou Young.
Sparganosis in humans is an incidental infection and is known to be associated with eating insufficiently cooked meat of frogs and snakes or drinking unboiled stream water. Although it can involve various internal organs, pulmonary and pleural involvement due to sparganum is rare. Because we recently experienced two cases involving lung parenchyma and pleura that were misdiagnosed as bacterial pneumonia and lung cancer, we herein intend to present them in detail.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Sparganosis; Multiple pulmonary nodules; Parasites; Pleural effusion.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200018

Two cases of Saint Louis encephalitis in HIV-1 infected patients in Buenos Aires
Provedor de dados: 55
Autores: Viloria,Guillermo Alberto; Kundro,Mariana Angelica; Toibaro,Javier Jose; Seijo,Alfredo; Losso,Marcelo Horacio.
Saint Louis encephalitis virus (SLE) is a mosquito borne disease. Only a small proportion of cases progress to severe clinical forms. There have been few reports on HIV-infected patients and the relationship between immunodeficiency and the course of the disease remains unclear. Herein we describe two cases of SLE in HIV-1-infected patients in Buenos Aires city.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV encephalitis arbovirus encephalitis virus; St Louis.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600019

Two family members with a syndrome of headache and rash caused by human parvovirus B19
Provedor de dados: 55
Autores: Pereira,Antonio Carlos M.; Barros,Roberto Alexandre Q.; Nascimento,Jussara Pereira do; Oliveira,Solange Artimos de.
Human parvovirus B19 infection can cause erythema infectiosum (EI) and several other clinical presentations. Central nervous system (CNS) involvement is rare, and only a few reports of encephalitis and aseptic meningitis have been published. Here, we describe 2 cases of B19 infection in a family presenting different clinical features. A 30 year old female with a 7-day history of headache, malaise, myalgias, joint pains, and rash was seen. Physical examination revealed a maculopapular rash on the patient's body, and arthritis of the hands. She completely recovered in 1 week. Two days before, her 6 year old son had been admitted to a clinic with a 1-day history of fever, headache, abdominal pain and vomiting. On admission, he was alert, and physical...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Human parvovirus B19; Aseptic meningitis; Erythema infectiosum.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000100006

Two outbreaks of mixed etiology associated with central venous catheters inserted by phlebotomy in critical neonates
Provedor de dados: 55
Autores: Brito,Denise V.D. de; von Dolinger,Elias J.O.; Abdallah,Vânia O.S.; Darini,Ana Lúcia C.; Gontijo Filho,Paulo P.
Staphylococcus aureus and coagulase-negative staphylococci are the main cause of sepsis in Neonatal Intensive Care Unit (NICU). Central venous catheters (CVCs) are an important part of critical neonates' treatment and are associated with sepsis. The aim of this study was to investigate two outbreaks caused by Staphylococcus aureus and Staphylococcus epidermidis associated with CVC inserted by phlebotomy in critical neonates. The surveillance was performed from January 2001 to December 2005 at the Brazilian NICU. The genotypic analysis of oxacillin susceptible S. aureus (OSSA) and oxacillin resistant S. epidermidis (ORSE) was performed based on pulsed-field gel electrophoresis (PFGE). Staphylococcus was the most frequent pathogen (65.8%) with highest...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Outbreak; Central venous catheter; Neonates.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300005

Type IV SCCmec found in decade old Brazilian MRSA isolates
Provedor de dados: 55
Autores: Reinert,Cristina; McCulloch,John Anthony; Watanabe,Shinya; Ito,Teruyo; Hiramatsu,Keiichi; Mamizuka,Elsa Masae.
Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes infection in hospitalized patients. Since its appearance in the 1960s, the SCCmec has evolved throughout the years into 5 different types (I-V), each bearing a different set of genes. Infection with MRSA SCCmec types I, II or III is almost exclusively restricted to hospitalised patients. However, recently, community acquired MRSA (CA-MRSA) infections have been reported with increasing frequency, usually caused by a type IV SCCmec MRSA in nosocomial settings. We studied the prevalence of SCCmec types in 50 nosocomial strains collected from 1995 to 1999. The SCCmec complex type and presence of Panton-Valentine leukocidin (PVL) were determined by PCR. Strains had been previously typed by PFGE...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nosocomial infections; Type IV SCCmec; Staphylococcus aureus; Methicillin-resistant; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300010

Typhidot M and Diazo test vis-à-vis blood culture and Widal test in the early diagnosis of typhoid fever in children in a resource poor setting
Provedor de dados: 55
Autores: Beig,Farzana K; Ahmad,Faraz; Ekram,Mohd; Shukla,Indu.
OBJECTIVE: Typhoid fever is a major public health problem. A test which is simple, reliable and can be carried out in small laboratories is the need of the hour. We prospectively evaluated typhidot M and Diazo tests vis-à-vis blood culture and Widal test in children. METHODS: Patients aged 6 months to 12 years, having fever of more than four days duration with clinical suspicion of typhoid fever were enrolled. Patients in whom other diagnosis was made served as control. The tests under scrutiny were validated against blood culture and then all the four tests were evaluated among patients who presented in the first week of illness. RESULTS: Blood culture was positive in only 27.3% of the cases. Among these culture positive cases, typhidot M test had the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Typhidot test; Diazo test; Widal test; Typhoid fever.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600007

Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil
Provedor de dados: 55
Autores: Entiauspe,Ludmila Gonçalves; Seixas,Fabiana Kömmling; Nunes,Emily Montosa; Rodrigues,Fernanda Martins; Dellagostin,Odir A.; Collares,Tiago; Silveira,Mariângela Freitas da.
Background:It is believed that Human Papillomavirus (HPV) and Human Immunodeficiency Virus coinfection contributes to increase the risk for cervical intraepithelial injuries. Several factors may contribute to cervical cancer (CC) development, including genetic variants such as TP53and MDM2 gene polymorphisms.Materials and methods:A hundred HIV-infected women were examined for HPV detection and its genotypes, as well as the frequencies of the SNPs Arg72Pro and SNP309 and their associations with CC risk factors. Nested Polymerase Chain Reaction (nPCR) was used for HPV detection and PCR-RFLP for TP53 and MDM2 SNP309 genotyping.Results:HPV DNA was detected in 68% of samples. A higher frequency of low-risk HPV genotypes (66.7%) was observed when compared to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV infection; HIV infection; Cervical cancer; Epidemiology.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600643

Uncommon vancomycin: induced side effects
Provedor de dados: 55
Autores: Rocha,Jaime Luís Lopes; Kondo,William; Baptista,Maria Inêz Domingues Kuchiki; Cunha,Clovis Arns da; Martins,Luzilma Terezinha Flenik.
Vancomycin has been used with increased frequency during the past 15 years and the most common toxicity with this drug is the "red man syndrome". Other adverse effects include neutropenia, fever, phlebitis, nephrotoxicity, ototoxicity, thrombocytopenia, interstitial nephritis, lacrimation, linear IgA bullous dermatosis, necrotizing cutaneous vasculitis and toxic epidermal necrolysis. Only two cases of vancomycin-induced Stevens-Johnson syndrome and one case of pancytopenia have been reported in the medical literature. The treatment for both situations is based on cessation of the vancomycin therapy; in cases of Stevens-Johnson syndrome, antihistamine and/or steroid agents can be used. This article reports a case of pancytopenia and a case of erythema major...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin; Stevens-Johnson; Pancytopenia; Reactions; Thrombocytopenia.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400007

Unrecognized pediatric and adult family members of children with acute brucellosis
Provedor de dados: 55
Autores: Çiftdoğan,Dilek Yılmaz; Aslan,Selda.
Abstract  Background and aim Brucellosis is an infectious, contagious and zoonotic disease that occurs worldwide. The family members of an index case of brucellosis may be especially susceptible, due to sharing the same source of infection and similar risk factors for brucellosis. In this study, we propose to screen pediatric and adult family members of brucellosis index cases for detecting additional unrecognized infected family members.  Materials and methods 114 family members of 41 pediatric patients with brucellosis were evaluated. All family members completed a brief questionnaire and were tested by a standard tube agglutination test (STA).  Results The majority of family members (n = 96, 84.2%) were children. Among the 114 family members, 42 (36.8%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brucellosis; Screening; Unrecognized; Turkey.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500520

Unusual clinical presentations of brucellosis in childhood
Provedor de dados: 55
Autores: Ulug,Mehmet; Yapici,Ferda; Can-Ulug,Nuray.
Tipo: Info:eu-repo/semantics/other
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400022

Unusual localization of an hydatid cyst: first reported case in Buenos Aires, Argentina
Provedor de dados: 55
Autores: Menghi,Claudia Irene; Gatta,Claudia Liliana.
Hydatidosis is a parasitic infection caused by the tapeworm larva of Echinococcus spp. Its relevance lies in its wide distribution, great number of clinical cases and outstanding morbility. Hydatid infection of the orbit comprises far less than 1% of the total incidence. This is a case of a patient from Argentina complaining of a two-week evolution proptosis of the right eye. A microscopic examination revealed the presence of protoscolices of Echinococcus spp. in the fluid obtained during the surgical proceedings. The patient was treated with oral albendazole. To our knowledge, this is the first case of occular hydatidosis diagnosed in the city of Buenos Aires, Argentina.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Echinococcosis; Orbit; Argentina.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100015

Unusual oral findings of the toxic epidermal necrolysis in an HIV-infected patient: a case report
Provedor de dados: 55
Autores: Vieira,Vinicius da Costa; Sarmento,Viviane Almeida; Ribeiro,Patricia Miranda Leite; Martins Netto,Eduardo; Brites,Carlos; Lins-Kusterer,Liliane.
ABSTRACT Erythema multiforme (EM), Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (TEN) have been reported as possible adverse effects of some classes of first-line antiretroviral drugs (ART) for HIV treatment. Herein we report an unusual presentation of TEN lesions associated with ART in an HIV-infected patient. The patient presented disseminated cutaneous eruption and oral lesions from the lips to the oropharynx region, causing odynophagia and dysphagia. In the tongue, circular, atypical erythematous lesions appeared, increasing in diameter over seven days and coalescing since then to complete remission. TEN treatment included efavirenz interruption, use of methylprednisolone, prophylactic antibiotic, and daily laser therapy with low-intensity...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Toxic epidermal necrolysis; Stevens-Johnson syndrome; Antiretroviral therapy; HIV.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500363

Ureteral stent infections: a prospective study
Provedor de dados: 55
Autores: Altunal,Nilsun; Willke,Ayse; Hamzaoğlu,Onur.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300361

Urethral myiasis
Provedor de dados: 55
Autores: Abe,Daniel K.; Rosa,Rafael T.L.; Dall' Oglio,Marcos F.; Fróes,Michele H.; Almeida,Bruno C.; Said,Luiz A.M.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300021

Urinary tract infection in non-hospitalized patients with cirrhosis and no symptoms of urinary tract infection: a case series study
Provedor de dados: 55
Autores: Cruz,Rita de Cássia Reis; Tanajura,Davi; Almeida,Delvone; Cruz,Marla; Paraná,Raymundo.
Bacterial infections are important factors in decompensation, and they increase the mortality rate of patients with liver cirrhosis. The most common infections among these patients are spontaneous bacterial peritonitis, pneumonia, skin infections and urinary tract infections (UTI). This transversal study evaluated the frequency of UTI in non-hospitalized patients with cirrhosis followed in a hepatology outpatient unit. Patients with clinical, laboratorial, echographic and/or histological diagnosis of cirrhosis were evaluated from April 2002 to August 2004. Patients who accepted participating in this study were submitted to clinical evaluation and the following laboratorial examinations: urine analysis, urine culture, blood culture and hepatic function...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Urinary tract infection; Infections in cirrhotics; Liver parenchyma chronic disease.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600004

Urine alpha1-microglobulin is a better marker for early tubular dysfunction than beta2-microglobulin among tenofovir-exposed human immunodeﬁciency virus-infected men who have sex with men
Provedor de dados: 55
Autores: Kang,Jing; Liu,Jing; Ding,Haibo; Li,Xiaolin; Wang,Qi; Guo,Xiaolin; Geng,Wenqing; Shang,Hong.
Objectives: Men who have sex with men are at risk of tenofovir nephrotoxicity due to its wide use in both treatment and prophylaxis for human immunodeﬁciency virus infection, but little is known about the urinary biomarkers of early renal dysfunction in this population. This study aims to identify useful biomarkers of early renal dysfunction among human immunodeﬁciency virus-infected men who have sex with men exposed to tenofovir.Methods: In a cross-sectional study urinary alpha1-microglobulin, beta2-microglobulin, N-acetyl-B-n-glucosaminidase and albumin were measured and expressed as the ratio-to-creatinine in 239 human immunodeﬁciency virus-infected men who have sex with men who were treatment naïve or receiving antiretroviral therapy with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alpha1-microglobulin; Beta2-microglobulin; Tenofovir; Human immunodeﬁciency virus.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400410

Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review
Provedor de dados: 55
Autores: Bezerra,Gilberto Silva Nunes; Barbosa Júnior,Walter Lins; Silva,Elis Dionísio da; Leal,Nilma Cintra; Medeiros,Zulma Maria de.
ABSTRACT Visceral leishmaniasis is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of visceral leishmaniasis are not so specific, confirmatory diagnostic methods with high sensitivity and specificity are needed. Noninvasive methods have been developed using urine as a clinical sample for visceral leishmaniasis diagnosis. In fact, there is a clear correlation between kidney impairment and Leishmania DNA in urine. However, it has been proved that Leishmania nucleic acid may also be isolated from patients without any sign of renal involvement. Even though urine has become a promissing biological sample, it is still not widely used due to several issues, such as (i) incomprehension of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Visceral leishmaniasis; Renal involvement; Diagnosis; Urine sample; DNA extraction.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200111

Use of antibacterial agents in an intensive care unit in a hospital in Brazil
Provedor de dados: 55
Autores: Santos,E.F. dos; Lauria-Pires,L.; Pereira,M.G.; Silva,A.E.; Rodrigues,I.P.; Maia,M.O.
It is essential to monitor the utilisation of antibacterial drugs in order to establish appropriate measures for their control. The pattern of usage of antibacterial drugs, and its association with indicators of hospital infection, has been investigated in a non-specialized adult intensive care unit (ICU) located in Santa Luzia Hospital (Brasília, DF, Brazil). The study was conducted between January 2001 and June 2004. Data concerning the utilisation of systemic antibacterial drugs, classified according to the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) system, and indicators of hospital infection, defined according to the National Nosocomial Infections Surveillance (NNIS) system, were obtained from appropriate hospital archives. During...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibacterial drugs; Intensive care unit; Hospital infections; Invasive practices.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300011

Use of antibiotics without medical prescription
Provedor de dados: 55
Autores: Volpato,Dalton Espíndola; Souza,Bárbara Vicente de; Dalla Rosa,Luana Gabriela; Melo,Luíz Henrique; Daudt,Carlos Antonio Stabel; Deboni,Luciane.
The inappropriate use of antibiotics for the treatment of infections is a worldwide problem that has implications for the cost of treatment and the development of resistant strains of bacteria. The use of antibiotics should follow specific criteria; they are on top of the list of self-medication drugs in countries that do not control their commercialization. OBJECTIVES: To determine the percentage of pharmacies that attend the public and sell antibiotics without medical prescription in a medium-sized city in Brazil, and analyze the variables involved in this procedure. MATERIALS AND METHODS: 107 of the 136 pharmacies registered in our city were evaluated. These pharmacies were visited by actresses who simulated having a sister with symptoms of a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Inappropriate use; Medical prescription; Pharmacies; ANVISA.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400004

Use of assisted reproductive technology to separate sperm from human immunodeficiency virus infected men resulting in pregnancy among serodiscordant couples
Provedor de dados: 55
Autores: Schuffner,Alessandro; Lisboa,Ana Paula; Rosa,Vinicius Bonato da; Silva,Monica Maria Gomes da.
Due to HIV care improvement, discordant couples more frequently seek help in order to conceive their own biological child. Besides the advance of antiretroviral therapy, unprotected intercourse is not a complete safe option, carrying a low but still present risk of HIV transmission. We report 10 serodiscordant couples in whom the male partner is HIV positive, submitted to sperm washing and intrauterine insemination. The procedure resulted in four pregnancies and no HIV transmission to mother or child was observed. Techniques of assisted reproduction can help HIV discordant couples to conceive biological offspring and is a safer option than unprotected intercourse.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV-1; Pregnancy; Insemination; Artificial reproduction.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400018

Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients
Provedor de dados: 55
Autores: Brites,Carlos; Nóbrega,Isabella; Netto,Eduardo Martins.
ABSTRACTAntiretroviral therapy has significantly evolved in the last decade, with an increasing number of new drugs and classes. Currently, even heavily experienced patients can be successfully treated with new regimens. In Brazil, the recent incorporation of some new antiretroviral drugs made it possible to suppress HIV plasma viremia in most treated patients, with significant benefits in terms of quality of life and survival. However, little has been published on outcomes of patients under new drugs-based regimens. We reviewed the safety and efficacy of antiretroviral regimens using recently introduced drugs in Bahia. Our results confirm that patients using darunavir, raltegravir, enfuvirtide, or etravirine presented with a high rate of virological...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Antiretroviral; Salvage therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500529

Use of rhu-GM-CSF in pulmonary tuberculosis patients: results of a randomized clinical trial
Provedor de dados: 55
Autores: Pedral-Sampaio,Diana Brasil; Netto,Eduardo Martins; Brites,Carlos; Bandeira,Antonio Carlos; Guerra,Conceição; Barberin,Maria Goreth; Badaró,Roberto.
It has been postulated that deficient or incomplete clinical and/or microbiological response to tuberculosis treatment is associated with cell-mediated immunological dysfunction involving monocytes and macrophages. A phase 2 safety trial was conducted by treating patients with either recombinant human granulocyte-macrophage colony-stimulating factor (rhu-GM-CSF) or a placebo, both in combination with anti-tuberculosis chemotherapy. Thirty-one patients with documented pulmonary tuberculosis were treated with rifampin/isoniazid for six months, plus pyrazinamide for the first two months. At the beginning of treatment, rhu-GM-CSF (125µg/M²) was randomly assigned to 16 patients and injected subcutaneously twice weekly for four weeks; the other 15 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; GM-CSF; Treatment.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400004

Use of selective media for detection of cephalothin-resistant bacteria in surgical patients
Provedor de dados: 55
Autores: Melo,Sérgio A.C.; Castro,Eduardo A.R.; Ponce-de-Leon,Antônio C.; Pereira,José A.A.
Bacterial colonization in hospitalized patients is an important step in nosocomial infections. Frequent employment of antimicrobials can modify patients' normal microbiota, favoring colonization and infection by antimicrobial-resistant microorganisms. First-generation cephalosporins are frequently used as prophylactic antibiotics in surgery. Intestinal, oropharyngeal and skin colonization by cephalothin-resistant microorganisms were studied in 60 pre-operative patients at the Hospital Universitário Pedro Ernesto. Feces were cultured in Eosin-methylene blue medium containing 32 µg/mL of cephalothin. Swabs obtained from the oropharynx and from skin were inoculated in cistein-lactose electrolytes-deficient medium containing 32 µg/mL of cephalothin. Isolated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Selective media; Cephalotin resistance; Surgical patients.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300001

Use of the D test method to detect inducible clindamycin resistance in coagulase negative staphylococci (CoNS)
Provedor de dados: 55
Autores: Perez,Leandro Reus Rodrigues; Caierão,Juliana; Antunes,Ana Lúcia Souza; d'Azevedo,Pedro Alves.
According to the National Committee for Clinical Laboratory Standards (NCCLS, 2004), a method to evaluate the inducible clindamycin resistance in accordance with an approach of the disks of erythromycin and clindamycin - the D test - has been reported. We analyzed the performance of this method in 200 coagulase negative staphylococci (CoNS) strains obtained from blood cultures of hospitalized patients at a general hospital in Southern Brazil. Twenty-seven clinical isolates with suitable profile (erythromycin-resistant and clindamycin-susceptible) were evaluated for the D test realization. Thus, only 5 CoNS were D test positive. The D test method showed to be simple and an important technique in the detection of inducible clindamycin resistance.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clindamycin; Resistance; D test.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200002

Usefulness of hybrid SPECT/CT for the 99mTc-HMPAO-labeled leukocyte scintigraphy in a case of cranial osteomyelitis
Provedor de dados: 55
Autores: Bruni,Chiara; Padovano,Federico; Travascio,Laura; Schillaci,Orazio; Simonetti,Giovanni.
Cranial osteomyelitis is a potentially fatal lesion. White blood cell scanning (WBC) with 99mTc-hexamethylpropylene amine oxime (HMPAO) has proven highly sensitive and specific in the diagnosis and follow-up of patients with suspected osteomyelitis. In this report we show the usefulness of SPECT and transmission CT performed simultaneously using a hybrid imaging device for the functional anatomic mapping of soft tissue and cranial bone infections. 99mTc-HMPAO-labeled leukocytes scintigraphy was performed on an elderly diabetic man with an intracranial mass lesion and with suspected temporal bone infection. Planar scans were acquired 30 min, 4 h, and 24 h after injection. SPECT/CT was obtained 6 h after tracer injection, using a dual-head camera coupled...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: SPECT/CT; Brain abscess; 99mTc-HMPAO-labeled leukocyte scintigraphy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600027

Usefulness of pharmacy dispensing records in the evaluation of adherence to antiretroviral therapy in Brazilian children and adolescents
Provedor de dados: 55
Autores: Ernesto,Aline Santarem; Lemos,Renata Muller Banzato Pinto de; Huehara,Maria Ivone; Morcillo,André Moreno; Vilela,Maria Marluce dos Santos; Silva,Marcos Tadeu Nolasco da.
INTRODUCTION: Adherence, which is crucial to the success of antiretroviral therapy (HAART), is currently a major challenge in the care of children and adolescents living with HIV/AIDS. OBJECTIVE: To evaluate the prevalence of nonadherence to HAART using complementary instruments in a cohort of children and adolescents with HIV/AIDS followed in a reference service in Campinas, Brazil. METHODS: The level of adherence of 108 patients and caregivers was evaluated by an adapted standardized questionnaire and pharmacy dispensing records (PDR). Non-adherence was defined as a drug intake lower than 95% (on 24-hour or seven-day questionnaires), or as an interval of 38 days or more for pharmacy refills. The association between adherence and clinical, immunological,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency; Syndrome; Child; Adolescent; Highly active antiretroviral therapy; Medication adherence.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400001

Using pegylated interferon alfa-2b and ribavirin to treat chronic hepatitis patients infected with hepatitis c virus genotype 1: are nonresponders and relapsers different populations?
Provedor de dados: 55
Autores: Silva,Giovanni Faria; Polônio,Rodrigo José; Pardini,Maria Inês Moura Campos; Corvino,Silvia Maria; Henriques,Rita Maria Saccomano; Peres,Mari Nilce; Coelho,Kunie Iabuki Rabello.
The combination of pegylated interferon (PEG-INF) and ribavirin is currently the best treatment for chronic hepatitis C, providing a sustained virological response (SVR) in 54%-63% of patients. In patients infected with hepatitis C virus (HCV) genotype 1, the SVR rate is 42%-52%. To evaluate the treatment efficacy of this drug combination, we conducted an open, prospective study of 58 consecutive treatment-naïve patients infected with HCV genotype 1 and treated at a university hospital, comparing those presenting an SVR (SVRs), nonresponders (NRs), and relapsers (RELs). Among the intent-to-treat patients, an end-of-treatment virological response was achieved in 69% of the sample as a whole and in 52% of the SVRs. We found that being an SVR was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Pegylated interferon alfa 2b; Genotype 1; Relapsers.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600006

Utility of multiplex real-time PCR in the diagnosis of extrapulmonary tuberculosis
Provedor de dados: 55
Autores: Raveendran,Reena; Wattal,Chand.
Abstract  Objective The diagnosis of extrapulmonary tuberculosis is still a challenge because of its pauci-bacillary nature. The aim of the study was to evaluate the role of a multiplex PCR assay in the diagnosis of extrapulmonary tuberculosis and to compare the efficiency of two targets, IS6110 and MPB64 to detect Mycobacterium tuberculosis.  Methods 150 extrapulmonary samples (61 pus/aspirate, 46 tissue, 32 body fluids, and 11 urine) from clinically suspected cases of tuberculosis were included in the study. All the samples were subjected to direct fluorescent microscopy, TB culture (BacT/ALERT 3D, biomerieux, Durham, North Carolina, USA) and a Multiplexed Tandem PCR targeting two mycobacterial DNA sequences, IS6110 and MPB64. Master-Mix reagents and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extrapulmonary tuberculosis; Multiplex PCR; IS6110; MPB64.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300003

Utility of the ceftazidime-imipenem antagonism test (CIAT) to detect and confirm the presence of inducible AmpC beta-lactamases among enterobacteriaceae
Provedor de dados: 55
Autores: Cantarelli,Vlademir Vicente; Inamine,Everton; Brodt,Teresa Cristina Z.; Secchi,Carina; Cavalcante,Bianca C.; Pereira,Fabiana de Souza.
Detection of AmpC beta-lactamase production by enterobacteria has been problematic. Contrary to ESBLs, no specific guidelines are available for detection and confirmation of AmpC production by clinical relevant microorganisms. Moreover, some bacterial species may produce inducible AmpC beta-lactamases that can be easily overlooked by routine susceptibility tests. We reported here a new test based on the strong inducible effect of imipenem on AmpC genes and the consequent antagonism with ceftazidime. This test is very simple and proved to be helpful in detecting AmpC-inducible enzymes among several species of clinical isolates.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AmpC; Inductible beta-lactamases; Screening tests; Imipenem; Cefoxitin screening.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200014

Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil
Provedor de dados: 55
Autores: Martins,Saulo; Livramento,Andréa do; Andrigueti,Michelle; Kretzer,Iara Fabricia; Machado,Marcos José; Spada,Celso; Treitinger,Arício.
Evidence-based strategies to improve the hepatitis B virus (HBV) vaccination coverage rates might help to reduce the burden caused by co-infection with HBV and human immuno-deﬁciency virus (HIV). In this study, the aim was to evaluate the vaccination coverage and immunity against HBV among HIV-infected individuals in South Brazil, and identify factors that are associated with compliance patterns and antibody reactivity. Three hundred HIV-infected men and women were included in this survey. The patients answered a standardized questionnaire, and vaccination cards were checked in order to assess hepatitis B vaccine status. A blood sample was collected for quantitative determination of antibody to hepatitis B virus surface antigen (anti-HBs). Participants...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis B; HBV Vaccination; Immunity.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200181

Vaccination coverage in a cohort of HIV-infected patients receiving care at an AIDS outpatient clinic in Espírito Santo, Brazil
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Vieira,Julia Vescovi; Ronchi,Nathália Rossoni.
Abstract This cross-sectional study assessed the immunization status of human immune deficiency virus (HIV)-infected patients receiving care at an outpatient clinic in Brazil. The sociodemographic characteristics, CD4 count and HIV viral load of 281 out of 612 adult outpatients were analyzed. A total of 331 patients were excluded because of no availability of vaccination cards. Chi-square or Fisher's exact test were used. Immunization coverage was higher for diphtheria/tetanus (59.79%) and hepatitis B (56.7%), and lowest for hepatitis A (6.8%) and for meningococcal group C (6%). Only 11.74% of the patients had received the influenza virus vaccine yearly since their HIV-infection diagnosis. No vaccination against influenza (p &lt; 0.034) or hepatitis B (p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Vaccination; Immunization coverage; Immunosuppressed.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500515

Vaccination status of people living with HIV/AIDS in outpatient care in Fortaleza, Ceará, Brazil
Provedor de dados: 55
Autores: Cunha,Gilmara Holanda da; Galvão,Marli Teresinha Gimeniz; Medeiros,Camila Martins de; Rocha,Ryvanne Paulino; Lima,Maria Amanda Correia; Fechine,Francisco Vagnaldo.
Abstract Antiretroviral therapy has increased the survival of patients with HIV/AIDS, thus necessitating health promotion practice with immunization. Vaccines are critical components for protecting people living with HIV/AIDS (PLWHA). The purpose of study was to analyze the vaccination status of PLWHA in outpatient care in Fortaleza, Ceará, Brazil. Cross-sectional study performed from June 2014 to June 2015. The screening was done with patients in antiretroviral therapy, 420 patients underwent screening, but only 99 met the inclusion criteria. Data were collected for interviews using forms to characterize sociodemographic, clinical and vaccination situations. Only 14 patients had complete vaccination schedules. The most used vaccines were hepatitis B,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency syndrome; HIV; Health promotion; Immunization; Immunization schedule.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500487

Validation and clinical application of a molecular method for the identification of Cryptococcus neoformans/Cryptococcus gattii complex DNA in human clinical specimens
Provedor de dados: 55
Autores: Rivera,Vanessa; Gaviria,Marcela; Muñoz-Cadavid,Cesar; Cano,Luz; Naranjo,Tonny.
ABSTRACT The diagnosis of cryptococcosis is usually performed based on cultures of tissue or body fluids and isolation of the fungus, but this method may require several days. Direct microscopic examination, although rapid, is relatively insensitive. Biochemical and immunodiagnostic rapid tests are also used. However, all of these methods have limitations that may hinder final diagnosis. The increasing incidence of fungal infections has focused attention on tools for rapid and accurate diagnosis using molecular biological techniques. Currently, PCR-based methods, particularly nested, multiplex and real-time PCR, provide both high sensitivity and specificity. In the present study, we evaluated a nested PCR targeting the gene encoding the ITS-1 and ITS-2...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcus neoformans/Cryptococcus gattiicomplex; Nested PCR; Cryptococcosis; Molecular diagnosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600563

Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients
Provedor de dados: 55
Autores: Gaviria,Marcela; Rivera,Vanessa; Muñoz-Cadavid,Cesar; Cano,Luz Elena; Naranjo,Tonny Williams.
Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensisand Paracoccidioides lutzii. The diagnosis of paracoccidioidomycosis is usually performed by microscopic examination, culture and immunodiagnostic tests to respiratory specimens, body fluids and/or biopsies; however these methods require laboratory personnel with experience and several days to produce a result. In the present study, we have validated and evaluated a nested PCR assay targeting the gene encoding the Paracoccidioides gp43membrane protein in 191 clinical samples: 115 samples from patients with proven infections other than...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paracoccidioides brasiliensis; Nested PCR; Paracoccidioidomycosis; Molecular diagnosis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400376

Validation and utilization of PCR for differential diagnosis and prevalence determination of Entamoeba histolytica/Entamoeba dispar in Salvador City, Brazil
Provedor de dados: 55
Autores: Santos,Fred Luciano Neves; Gonçalves,Marilda de Souza; Soares,Neci Matos.
Amoebiasis is an infection caused by Entamoeba histolytica and is a potential health risk in countries in which health barriers are inappropriate. Since the discovery of Entamoeba dispar, the prevalence of amoebiasis has been modified. OBJECTIVE: This study has standardized the PCR technique applied for the diagnosis of different species of the E. histolytica/E. dispar complex and has evaluated the prevalence of infection among patients attending private and public clinical laboratories in Salvador City, Bahia State, Brazil. RESULTS: Analysis of 52,704 stool samples by microscopic examination demonstrated that 1,788 (3.4%) were positive for the E. histolytica/E. dispar complex and infection occurred more often in samples originated from public clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amebiasis; Entamoeba histolytica; Diagnosis; Prevalence.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200005

Validation of criteria for nosocomial use of amikacin in Brazil with the Delphi technique
Provedor de dados: 55
Autores: Noblat,L.; Oliveira,M.G.G.; Santos-Jesus,R.; Noblat,A.C.B.; Badaró,R.
The Delphi technique has been used since the 1950s to collect the opinions of experts; to gauge their indications, and in some instances, to develop a consensus. This systematic collection and aggregation of informed judgments from a group of experts on specific questions or issues is a highly efficient and cost-effective means to establish guidelines and policies, when compared to other strategies, such as committee meetings or personal interviews. OBJECTIVE: Examine the content validation process of the proposed criteria of the American Society of Health System Pharmacists (ASHP) for amikacin use in hospital settings. MATERIAL AND METHODS: The Delphi technique was applied using the proposed ASHP criteria questionnaire containing 102 specific questions...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Delphi technique; Content validation; Drug use utilization; Amikacin; Consensus technique.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300004

Validity and reliability of the 36-Item Short Form Health Survey questionnaire version 2 among people living with HIV in Brazil
Provedor de dados: 55
Autores: Lins-Kusterer,Liliane; Valdelamar,Juliet; Aguiar,Carolina Villa Nova; Menezes,Marta Silva; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT  Background: The 36-Item Short Form Health Survey questionnaire (SF-36) is a widely used instrument for evaluating health-related quality-of-life (HRQoL). The psychometric validation of the SF-36 version 2.0 (SF-36v2) in HIV-infected patients had not yet conducted in Brazil.  Aim: To test data quality, reliability and validity of the SF-36v2 as a measure of HRQoL among Brazilian individuals living with HIV.  Methods: A cross-sectional study included 393 HIV-infected patients in whom HRQoL was assessed by using the SF-36v2 questionnaire. Demographic characteristics, socioeconomic status and clinical data were also collected. The SF-36 version 1 translated into Brazilian-Portuguese was adapted and introduced version 2 improvements according to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Health-related quality of life; Factor analysis; Validation studies.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500313

Validity of the polymerase chain reaction in the diagnosis of clinically suspected cases of American visceral leishmaniasis
Provedor de dados: 55
Autores: Pedrosa,Celia Maria Silva; Ximenes,Ricardo Arraes de Alencar; Almeida,Wendell Alexandre Pinheiro de; Rocha,Eliana Maria Mauricio da.
To test the validity of the polymerase chain reaction for diagnosing American visceral leishmaniasis, 88 suspected cases were studied. Diagnosis was confirmed in 47 (53.5%) and ruled out in 41 (46.5%) patients. Samples of bone marrow and peripheral blood were processed by polymerase chain reaction to evaluate the sensitivity and specificity of the test and its agreement beyond chance with microscopy examination. The polymerase chain reaction was positive in bone marrow of 100% of the patients with amastigotes seen with microscopy examination, and in 59.5% in those where no parasite were seen. Agreement beyond chance between visualization of the parasite in bone marrow aspirates and polymerase chain reaction was considered weak (Kappa = 0.41). Concordance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: American visceral leishmaniasis; Diagnosis; Polymerase chain reaction; Peripheral blood; Bone marrow blood.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300003

Value of real-time polymerase chain reaction in bronchoalveolar lavage fluid for diagnosis of pediatric pulmonary tuberculosis
Provedor de dados: 55
Autores: Wang,Xinfeng; Wu,YanHua; Zhang,Kaihui; Guan,Cuiping; Gao,Xusheng; Wang,Maoshui.
Tipo: Info:eu-repo/semantics/other
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600018

Vancomycin serum concentrations in pediatric oncologic/hematologic intensive care patients
Provedor de dados: 55
Autores: Silva,Dáfne Cardoso Bourguignon da; Seixas,Gláucia Toribio Finoti; Araujo,Orlei Ribeiro de; Arduini,Rodrigo Genaro; Carlesse,Fabianne Altruda de Moraes Costa; Petrilli,Antonio Sergio.
BACKGROUND: Usual treatment regimens with vancomycin often fail to provide adequate serum levels in patients with severe infections. METHODS: Retrospective analysis of vancomycin trough serum measurements. The following parameters were calculated by Bayesian analysis: vancomycin clearance, distribution volume, and peak estimated concentrations. The area under the concentration curve (AUC) (total daily dose/24 h clearance of vancomycin) was used to determine the effectiveness of treatment through the ratio of AUC/minimum inhibitory concentration (MIC) above 400, using MIC = 1 µg/mL, based on isolates of Staphylococci in cultures. RESULTS: Sixty-one vancomycin trough measurements were analyzed in 31 patients. AUC/MIC &gt; 400 was obtained in 34 out of 61...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Immunosuppression; Drug resistance; Microbial; Staphylococcus; Anti-bacterial agents; Pharmacokinetics.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400009

Vancomycin: the need to suit serum concentrations in hemodialysis patients
Provedor de dados: 55
Autores: Marengo,Lívia Luize; Del Fiol,Fernando de Sá; Oliveira,Sara de Jesus; Nakagawa,Celso; Croco,Eduardo Leite; Barberato-Filho,Silvio; Peçanha,Marcela Pellegrini; Silva,Douglas Felix da; Toledo,Maria Inês de.
The vancomycin dose for hemodialysis (HD) patients should be adjusted by monitoring drug serum concentrations. However, this procedure is not available in most health services in Brazil, which usually adopts protocols based on published studies. The trials available are controversial, and several have not been conducted with current dialyzers. This study aimed at assessing the suitability of vancomycin serum concentrations in HD patients at a public hospital. Blood samples of HD patients were collected from November 2006 to May 2007, at time intervals of 48, 96, 120, or 168 hours after vancomycin administration. Drug measurement was performed with polarized light immunofluorescence. Approximately 86% of trough vancomycin serum concentrations were below the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Vancomycin; Chronic renal failure; Hemodialysis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200019

Vancomycin use in a brazilian teaching hospital: comparison with the Hospital Infection Controlpractices Advisory Committee Guidelines (HICPAC)
Provedor de dados: 55
Autores: Melo,Daniela Oliveira de; Ribeiro,Eliane.
This study describes vancomycin prescribing patterns in an average complexity hospital and compare the guidelines proposed by the Hospital Infection Control Practices Advisory Committee (HICPAC). The study was conducted in a 256-bed secondary-care hospital. Data were collected of all patients given vancomycin from March 2003 to February 2004, using a standardized chart-extraction form designed. Appropriate and inappropriate use was reviewed according to the Hospital Infection Control Practices Advisory Committee (HICPAC) guidelines on prudent vancomycin use. Out of 118 prescriptions, 95 (80.5%) were considered appropriate. Out of these 95 orders, 77 (81.1%) were administered for empiric treatment of suspected Gram-positive infections, 17 (17.9%) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin; Infection; Guidelines; Antimicrobial use.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300001

Vancomycin use in a hospital with high prevalence of Methicillin-Resistant Staphylococcus aureus: comparison with Hospital Infection Control Practices Advisory Committe Guidelines (HICPAC)
Provedor de dados: 55
Autores: Melo,Daniela Oliveira de; Sasaki,Marli; Grinbaum,Renato Satovschi.
This study evaluates vancomycin prescribing patterns in a tertiary-care hospital, with high prevalence of methicillin-resistant Staphylococcus aureus, comparing with the guidelines proposed by the Hospital Infection Control Practices Advisory Committee. The study was conducted in a 930-bed tertiary-care hospital, during 40 days (March 10 to April 30, 2003). Data were collected of all patients given vancomycin, using a standardized chart-extraction form designed. Inappropriate use was subdivided in five categories: empiric therapy without risk factors; continued empiric use for presumed infections in patients whose cultures were negative for beta-lactam-resistant Gram-positive microorganisms; treatment of infections caused by beta-lactam-sensitive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin; Infection; Guidelines; Antimicrobial use.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100014

Vancomycin-resistant enterococci, colonizing the intestinal tract of patients in a university hospital in greece
Provedor de dados: 55
Autores: Metallidis,Simeon; Chatzidimitriou,Maria; Tsona,Afroditi; Bisiklis,Alexandros; Lazaraki,Georgia; Koumentaki,Eleni; Gikas,Ahilleas; Alexiou-Daniel,Stela; Nikolaidis,Pavlos.
OBJECTIVE: Determine the prevalence of Vancomycin-resistant enterococci (VRE) colonizing the intestinal tract of hospitalized patients and define risk factors. MATERIAL AND METHODS: A point prevalence survey of VRE fecal carriage was carried out among patients who stayed at a 600-bed teaching hospital for at least two days. Resistance to vancomycin was detected by the E-test method. Epidemiological data was recorded for all patients included in the study and was used for the risk factor analysis. RESULTS: A total of 128 patients hospitalized for at least two days were enrolled in this investigation. Thirty-nine patients (30.5%) were colonized with vancomycin-resistant enterococci. Twenty-three of the 39 strains were identified as Enterococcus faecium, 13...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vancomycin-resistant enterococci; Inestinal tract; Hospitalized patients.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300005

Vancomycin-resistant van a phenotype Enterococcus faecalis: first case in Minas Gerais state and epidemiological considerations
Provedor de dados: 55
Autores: Ribas,Rosineide Marques; Darini,Ana Lúcia da Costa; Moreira,Tomaz Aquino; Freitas,Claudete; Gontijo Filho,Paulo P.
We report the first case of vancomycin-resistant Enterococcus faecalis with VanA phenotype and vanA genotype isolated from a surgical patient in a general Hospital in Uberlândia, state of Minas Gerais, Brazil.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nosocomial infections; Antibiotic resistance; VRE.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400015

Varicella pneumonia in immunocompetent adults: report of two cases, with emphasis on high-resolution computed tomography findings
Provedor de dados: 55
Autores: Gasparetto,Emerson L.; Warszawiak,Danny; Tazoniero,Priscilla; Escuissato,Dante L.; Marchiori,Edson.
We report two cases of varicella pneumonia in immunocompetent patients, with emphasis on high-resolution computer tomography manifestations. The predominant findings consisted of multiple bilateral nodules, ranging from 1-10 mm in diameter, with or without a surrounding halo of ground-glass attenuation. Other findings include ground-glass opacities, focal areas of consolidation and small pleural effusions.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Lung diseases; Lung infection; Computed tomography; High-resolution computed tomography.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300010

Varicella-zoster virus encephalitis in an AIDS patient
Provedor de dados: 55
Autores: Toledo,P.V.; Pellegrino,L.N.; Cunha,C.A.
A 37-year-old man with a three-year history of Acquired Immunodeficiency Syndrome was admitted with impaired consciousness, seizures and fever. He was on highly active antiretroviral therapy and on neurotoxoplasmosis secondary prophylaxis. Laboratory exams from two months before showed a CD4 cell count of 37/µL and a viral load of 230,000 copies/mL. Three months before admission he developed herpetic skin rash in the right trunk and acyclovir was added to his treatment regimen. On physical exam he was drowsy and had motor and sensory aphasia. The patient had elevated protein levels and normal pressure in the cerebrospinal fluid (CSF). Contrast enhanced computed tomography scan of the brain showed a hypodense lesion in the left parietal lobe, with poorly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Varicella-zoster encephalitis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300010

Vascular access-related infections in HIV patients undergoing hemodialysis: case description and literature review
Provedor de dados: 55
Autores: Castro,Carlos E. Figueroa; Madariaga,Miguel G.
Poor immune status, the use of a vascular access different from an AV fistula, and intravenous drug use (IDU) may favor increased rates of vascular access infections among HIV infected patients on hemodialysis. Staphylococcus spp. and Streptococcus spp. are the main cause of these infections, but Gram-negative rods and fungi have been found as well. Using an AV fistula when possible, and eliciting a history of IVDU on every visit may prevent this type of infection. When infections are present, coverage for both Gram-positive and negative organisms is recommended. Additional studies specifically addressing the issue of vascular access infection in HIV infected patients are required.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Chronic kidney disease; Renal dialysis; Catheter-related infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600017

Vasculitis: an unusual manifestation in an HIV-infected patient
Provedor de dados: 55
Autores: Manuel,Ana; Victório,Tânia; Gomes,Constança; Martins,Telmo; Dias Neto,António.
Human immunodeﬁciency virus (HIV) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. We describe a patient who developed manifestations suggestive of extremities vasculitis with no identiﬁable risk factors other than HIV, Epstein Barr and Herpes Simplex Virus (HSV) type 1 co-infection. Physicians should be aware that vasculitis may have a heterogeneous presentation and occur associated with HIV infection. Although unusual, this association should be recognized for early proper treatment and prevention of ischemia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vasculitis; HIV; Epstein Barr virus; Herpes Simplex Virus.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400439

Vasculonecrotic reactions in leprosy
Provedor de dados: 55
Autores: Fogagnolo,Letícia; Souza,Elemir Macedo de; Cintra,Maria Letícia; Velho,Paulo Eduardo Neves Ferreira.
Multibacillary, lepromatous or borderline leprosy patients may present two types of vasculonecrotic reactions: Lucio phenomenon and that associated with erythema nodosum leprosum. Despite they can be distinguished through clinical and histological characteristics; both are often used as synonyms. It is said that leprosy reaction should be properly classified for therapeutic reasons, since it is well known that in Lucio phenomenon there is not a good response to thalidomide. The authors reported two cases of vasculonecrotic phenomena in lepromatous leprosy sharing clinical and histopathological characteristics of both reaction subtypes. The findings may indicate the spectral nature of the reaction phenomena in leprosy and emphasize the importance of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leprosy; Lepromatous; Erythema nodosum; Vasculitis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300016

Ventilator-associated pneumonia agents in Brazilian Neonatal Intensive Care Units - a systematic review
Provedor de dados: 55
Autores: Silva,André Ricardo Araujo da; Silva,Thais Carolina da; Bom,Gabriel José Teixeira; Vasconcelos,Raissa Maria Bastos; Simões Junior,Robinson.
ABSTRACT  Introduction Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections (HAI) in neonates admitted in neonatal intensive care units (NICUs).  Methods We did a systematic review using PRISMA methodology to identify the main etiological agents in Brazilian NICUs. Eligible studies published without period restriction were identified in PUBMED, SCIELO, LILACS and DOAJ. Studies were included if they were conducted in neonates hospitalized at NICU. Studies done in outpatient care, neonates outside NICU, emergency department, primary care, long-term care facilities or a combination of these were excluded.  Results We identified 6384 articles in the initial search and four papers met the inclusion criteria. In all...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Systematic reviews; Ventilator-associated pneumonia; Newborn; Etiological agents.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400338

Ventilator-associated pneumonia in an adult clinical-surgical intensive care unit of a Brazilian university hospital: incidence, risk factors, etiology, and antibiotic resistance
Provedor de dados: 55
Autores: Rocha,Laura de Andrade da; Vilela,Carolina Assis Pereira; Cezário,Renata Cristina; Almeida,Alair Benedito; Gontijo Filho,Paulo.
The objective of this study was to evaluate clinical characteristics, etiology, and resistance to antimicrobial agents, among patients with ventilator-associated pneumonia (VAP). A case study vs. patients control under mechanical ventilation and hospitalized into clinical-surgical adults ICU of HC-UFU was performed from March/2005 to March/2006. Patients under ventilation for over 48 h were included in the study including 84 with diagnosis of VAP, and 191 without VAP (control group). Laboratory diagnosis was carried out through quantitative microbiological evaluation of tracheal aspirate. The identification of pathogens was performed by classical microbiological tests, and the antibiotics sensitivity spectrum was determined through the CLSI technique. VAP...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator-associated pneumonia; Intensive care unit (ICU); Antibiotic resistance.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100017

Ventilator-associated pneumonia: the influence of bacterial resistance, prescription errors, and de-escalation of antimicrobial therapy on mortality rates
Provedor de dados: 55
Autores: Souza-Oliveira,Ana Carolina; Cunha,Thúlio Marquez; Passos,Liliane Barbosa da Silva; Lopes,Gustavo Camargo; Gomes,Fabiola Alves; Röder,Denise Von Dolinger de Brito.
Abstract Ventilator-associated pneumonia is the most prevalent nosocomial infection in intensive care units and is associated with high mortality rates (14–70%).  Aim This study evaluated factors influencing mortality of patients with Ventilator-associated pneumonia (VAP), including bacterial resistance, prescription errors, and de-escalation of antibiotic therapy.  Methods This retrospective study included 120 cases of Ventilator-associated pneumonia admitted to the adult adult intensive care unit of the Federal University of Uberlândia. The chi-square test was used to compare qualitative variables. Student's t-test was used for quantitative variables and multiple logistic regression analysis to identify independent predictors of mortality.  Findings...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilator-associated pneumonia; Bacterial resistance; Prescription errors; De-escalation of antibiotic therapy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500437

Ventilator-associated pneumonia with Col-S strains: a successful comeback of colistin!
Provedor de dados: 55
Autores: Mukhopadhyay,C.; Krishna,S.; Vandana,K.E.; Shenoy,A.; Bairy,I.
Emergence of multi and pan-drug resistant Gram-negative bacteria causing nosocomial infections in intensive care settings has become a challenge for clinicians. The mortality rate of ventilator-associated pneumonia (VAP) is known to increase when the initial microbiological diagnosis and antimicrobial therapy are inappropriate. We present a case of a 18-year-old man, who after being admitted following an accident, had developed VAP due to multi-drug resistant Pseudomonas aeruginosa and Acinetobacter spp. and had a downhill clinical course despite broad-spectrum antibiotic treatment. The strains were found to be Col-S, as the susceptibility was tested. Colistin was instituted, with remarkable recovery. It is imperative to diagnose VAP with multi-drug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Colistin; Col-S strain; Ventilator-associated pneumonia.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500018

Ventriculitis: a rare case of primary cerebral toxoplasmosis in AIDS patient and literature review
Provedor de dados: 55
Autores: Cota,Gláucia Fernandes; Assad,Elisa Caroline Pereira; Christo,Paulo Pereira; Giannetti,Alexandre Varella; Santos Filho,José Augusto Malheiros dos; Xavier,Marcelo Antonio Pascoal.
Cerebral toxoplasmosis remains the most important neurological opportunistic infection and the most common cause of intracerebral mass lesion in patients with acquired immunodeficiency syndrome (AIDS). We report a case of an adult AIDS patient with an atypical pattern of toxoplasma encephalitis, presenting with ventriculitis and obstructive hydrocephalus without any focal parenchymal lesion.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cerebral toxoplasmosis; Ventriculitis; Hydrocephalus; AIDS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100022

Verruca vulgaris
Provedor de dados: 55
Autores: Viana,Graça Maria de Castro; Ithamar,Jorim; Silva,Antônio Rafael da; Nascimento,Maria do Desterro S. Brandão do; Azevedo,Conceição M.P.S.
Tipo: Info:eu-repo/semantics/article
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300018

Vertebral osteomyelitis and epidural abscesses caused by Prevotella oralis: a case report
Provedor de dados: 55
Autores: Goyal,Hemant; Arora,Shitij; Mishra,Sneha; Jamil,Syed; Shah,Uday.
An interesting case of pyogenic vertebral osteomyelitis with multiple epidural abscesses caused by non-pigmented Prevotella oralis is reported. The patient was a 68-year-old female who presented to the emergency room (ER) with severe pain and tenderness in her lower back with fever. She had recently undergone esophagogastroduodensoscopy (EGD) for complaints of esophageal reflux, which showed submucosal cyst in the esophagus. Magnetic resonance imaging (MRI) of the thoracic spine revealed multiple spinal epidural abscesses with signal enhancement at the level of T6 and T7, suggestive of vertebral osteomyelitis. Two blood cultures drawn one hour apart grew Prevotella oralis. The body fluid aspirated from the abscesses was also positive for the anaerobic...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Anaerobes; Prevotella; Vertebral osteomyelitis.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600017

Vertical transmission of HIV and toxoplasma by reactivation in a chronically infected woman
Provedor de dados: 55
Autores: Fernandes,Regina Célia de Souza Campos; Vasconcellos,Vanessa Perez; Araújo,Luciana Cordeiro de; Medina-Acosta,Enrique.
Tipo: Info:eu-repo/semantics/article
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100015

Vibrio vulnificus infection in São Paulo, Brazil: case report and literature review
Provedor de dados: 55
Autores: Araujo,Maria Rita Elmor de; Aquino,Caroline; Scaramal,Elton; Ciola,Claudete Sílvia; Schettino,Guilherme; Machado,Marcel Cerqueira Cesar.
Non cholera Vibrio may cause conjunctivitis, wound infection, gastroenteritis and serious sepsis. Transmission to men is through contact with skin, mucosa or wounds exposed to marine water, and consumption of certain barely cooked or raw seafood, more frequently in the summer. This is one of the first cases of severe infection related to Vibrio vulnificus described in Brazil. The patient was an old man, who ingested seafood in Guarujá, a seashore city near São Paulo, 3 days before hospitalization. He was admitted to the emergency room in an ill state with septic shock. On 2 sets of blood culture a highly virulent microorganism was isolated, Vibrio vulnificus, which leads to sepsis and frequently to death in susceptible patients. The objective of this...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vibrio vulnificus; Septic shock; Risk factors.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200029

Viral acute gastroenteritis: clinical and epidemiological features of co-infected patients
Provedor de dados: 55
Autores: Ferreira,Carla Elizabeth de Oliveira; Raboni,Sonia Mara; Pereira,Luciane Aparecida; Nogueira,Meri Bordignon; Vidal,Luine Rosele Renaud; Almeida,Sérgio Monteiro.
BACKGROUND: Acute gastroenteritis (AGE) is a common disorder that affects children worldwide. It is usually caused by viral agents, including rotavirus, enteric adenovirus, norovirus, and astrovirus groups. Currently, there are few reports about co-infection among these viruses, mainly in Brazil. METHODS: This is a retrospective study in which 84 rotavirus-positive samples from hospitalized patients at a teaching hospital in Southern Brazil, collected in the 2001-2010 period, were analyzed by polymerase chain reaction (PCR) and reverse transcription - polymerase chain reaction (RT-PCR), for the investigation of enteric adenovirus, astrovirus, and norovirus. RESULTS: In total, 12 of the 84 (14%) samples were positive to enteric adenovirus or norovirus....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Co-infection; Viral gastroenteritis; Oiarrhea; Rotavirus A; Norovirus; Enteric adenovirus.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300009

Viral detection profile in children with severe acute respiratory infection
Provedor de dados: 55
Autores: Canela,Luciana Nascimento Pinto; Magalhães-Barbosa,Maria Clara de; Raymundo,Carlos Eduardo; Carney,Sharon; Siqueira,Marilda Mendonca; Prata-Barbosa,Arnaldo; Cunha,Antonio José Ledo Alves da.
ABSTRACT  Objectives: The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic.  Method: Longitudinal observational retrospective study, with patients aged 0–18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009. The results of respiratory samples which were sent to the Laboratory of Fiocruz/RJ and clinical data extracted from specific forms were analyzed.  Results: Of 71 samples, 38% tested positive for H1N1 virus. Of the 63 samples tested for other viruses, 58 were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pandemic H1N1 Influenza; Co-detection; Pediatric intensive care unit; Severe acute respiratory infection (SARI); Child.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500402

Viral genotypes and human rs12979860 polymorphism of the IFNL3 gene in hepatitis C infected patients in Southern Brazil
Provedor de dados: 55
Autores: Frizon,Kelen; Alves,Camila Fernanda da Silveira; Borchardt,Alessandra Caroline; Lunge,Vagner Ricardo; Simon,Daniel.
Tipo: Info:eu-repo/semantics/other
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200229

Viral hepatitis in patients infected with human immunodeficiency virus
Provedor de dados: 55
Autores: Pavan,Maria Helena P.; Aoki,Francisco Hideo; Monteiro,Dinaida Teresa; Gonçales,Neiva Sellan L.; Escanhoela,Cecília Amélia F.; Gonçales Júnior,Fernando L.
From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%. Intravenous drug use was reported by 29%; it was the most important risk factor for HIV transmission. The alanine aminotransferase quotient (qALT) was &gt;1 for 40% of the patients, 93.6% had anti-hepatitis A virus antibody, 5.3% presented hepatitis B surface antigen, 44% were anti-hepatitis B core antigen positive and 53.8% were anti-hepatitis C virus (anti-HCV) positive. The anti-HCV test showed a significant association with qALT&gt;1. Patients for whom the probable HIV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C virus; Human immunodeficiency virus; Alanine aminotransferase quotient; Anti-hepatitis A antibody; Hepatitis B surface antigen; Anti-hepatitis B core antigen (anti-HBc).
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400005

Virologic and immunologic effectiveness of darunavir-based salvage therapy in HIV-1-infected adults in a Brazilian clinical practice setting: results of a multicenter and retrospective cohort study
Provedor de dados: 55
Autores: Ribeiro,Karina Mota; Biscione,Fernando Martin; Westin,Mateus Rodrigues; Machado,Danielle Pessoa; Greco,Dirceu Bartolomeu; Tupinambás,Unaí.
Background:Darunavir has been proven efficacious for antiretroviral-experienced HIV-1-infected patients in randomized trials. However, effectiveness of darunavir-based salvage therapy is understudied in routine care in Brazil.Methods:Retrospective cohort study of HIV-1-infected patients from three public referral centers in Belo Horizonte, who received a darunavir-based therapy between 2008 and 2010, after virologic failure. Primary endpoint was the proportion of patients with viral load &lt;50 copies/mL at week 48. Change in CD4 cell count was also evaluated. Outcome measures were analyzed on an intent-to-treat basis applied to observational studies. Sensitivity analysis was conducted to evaluate the impact of missing data at week 48. Predictors of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV-1; Highly active antiretroviral therapy; Salvage therapy; Multiple viral drug resistance; Genotyping techniques.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100001

Virological suppression in children and adolescents is not influenced by genotyping, but depends on optimal adherence to antiretroviral therapy
Provedor de dados: 55
Autores: Abreu,Juliana Costa de; Vaz,Sara Nunes; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT  Objective: To evaluate the virological outcomes in children and adolescents infected with HIV-1 in Salvador, Bahia according to genotyping results.  Methods: We retrospectively evaluated the rates of virological suppression of children and adolescents submitted to HIV-1 genotyping test from January/2008 to December/2012. The participants were followed in the two referral centers for pediatric AIDS care, in Salvador, Brazil. Resistance mutations, drug sensitivity profiles, and viral subtypes were analyzed using the Stanford HIV-1 Drug Resistance Database. Adherence was estimated by drugs withdrawal at pharmacies of the two sites.  Results: 101 subjects were included: 35 (34.6%) were drug-naïve, and the remaining 66 were failing ART. In drug-naïve...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; Virological suppression; Genotyping; Adherence.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300219

Virulence genes and genetic relationship of L. monocytogenes isolated from human and food sources in Brazil
Provedor de dados: 55
Autores: Almeida,Rosana Macedo de; Barbosa,André Victor; Lisbôa,Rodrigo de Castro; Santos,André Felipe das Mercês; Hofer,Ernesto; Vallim,Deyse Christina; Hofer,Cristina Barroso.
ABSTRACT The herein presented assay provided a bacteriological and molecular characterization of 100 samples of L. monocytogenes isolated from human (43) and food (57) sources, from several regions of Brazil, and collected between 1975 and 2013. Antigenic characterization defined 49% of serotype 4b samples, followed by 28% of serotype 1/2b, 14% of serotype 1/2c, 8% of serotype 1/2a, and 1% of serotype 3b. Both type of samples from human and food origin express the same serotype distribution. Multiplex PCR analysis showed 13 strains of type 4b with the amplification profile 4b-VI (Variant I). Virulence genes hly, inlA, inlB, inlC, inlJ, actA, plcA, and prfA were detected in all samples, highlighting a deletion of 105pb on the actA gene in 23% of serotype 4b...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Listeria monocytogenes; Listeriosis; Virulence; Food; PFGE; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300282

Virus C genotype predisposes to primary hypothyroidism during interferon-α treatment for chronic hepatitis C
Provedor de dados: 55
Autores: Pavan,Maria Helena Postal; Pavin,Elizabeth João; Gonçales Jr,Fernando Lopes; Zantut-Wittmann,Denise Engelbrecht.
OBJECTIVE: The treatment of the chronic hepatitis C (HCV) with α-interferon is associated with thyroid dysfunction (TD). The aim of this study was to evaluate thyroid function outcome among patients with chronic HCV under treatment with conventional interferon (IFN) or peguilated interferon (PEG-IFN) in association with ribavirin. PATIENTS AND METHODS: We studied 293 patients with chronic HCV, submitted to drug therapy for 24 or 48 weeks. Initially, we evaluated FT4, TSH, TPOAb, TgAb, and continued to monitor FT4 and TSH every three months during therapy and six months thereafter. RESULTS: At baseline, TD prevalence was 6.82% (n = 20); 6.14% hypothyroidism; 0.68% hyperthyroidism. TPOAb was present in 5.46% of euthyroid patients. Out of 273 euthyroid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hypothyroidism hepatitis C; Chronic interferon-α.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000500006

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China
Provedor de dados: 55
Autores: Zhao,Ting; Ye,Zhixu; Wang,Binlin; Cui,Yuxia; Nie,Yingjie; Yang,Bin; Chen,Kun; Zhang,Hua; Hu,Fangfang; Yu,Fuxun.
ABSTRACT To investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou Provincial People's Hospital, from December 2017 to March 2018, and inoculated to Hep-2 cells to isolate HRSV. Cells that showed cytopathic effect (CPE) were then confirmed by indirect immunofluorescence assay and reverse transcription. The sequence of the PCR products was determined for HRSV isolates, and the genetic variation was analyzed. Out of 196 nasopharyngeal aspirate samples, HRSV were isolated in 39. The second hypervariable region at the 3' terminal of glycoprotein gene (HVR2) sequence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human respiratory syncytial virus; Virus isolation; RT-PCR; HVR2; Phylogenetic analysis; Molecular epidemiology.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600427

Viruses vector control proposal: genus Aedes emphasis
Provedor de dados: 55
Autores: Reis,Nelson Nogueira; Silva,Alcino Lázaro da; Reis,Elma Pereira Guedes; Silva,Flávia Chaves e; Reis,Igor Guedes Nogueira.
Abstract The dengue fever is a major public health problem in the world. In Brazil, in 2015, there were 1,534,932 cases, being 20,320 cases of severe form, and 811 deaths related to this disease. The distribution of Aedes aegypti, the vector, is extensive. Recently, Zika and Chikungunya viruses had arisen, sharing the same vector as dengue and became a huge public health issue. Without specific treatment, it is urgently required as an effective vector control. This article is focused on reviewing vector control strategies, their effectiveness, viability and economical impact. Among all, the Sterile Insect Technique is highlighted as the best option to be adopted in Brazil, once it is largely effectively used in the USA and Mexico for plagues related to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dengue; Vector control; Aedes; Arbovirus; Sterile insect technique.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400457

Visceral Leishmaniasis/HIV co-infection in northeast Brazil: evaluation of outcome
Provedor de dados: 55
Autores: Távora,Lara Gurgel Fernandes; Nogueira,Marina Bizerril; Gomes,Sofia Teixeira.
ABSTRACT Since the beginning of the HIV burden, Visceral Leishmaniasis (VL)/HIV co-infection has been diagnosed not only in areas where VL is endemic (Latin America, India, Asia, Southern Europe), but also in North America, were it is considered an opportunistic disease. Clinical presentation, diagnostic tests sensitivity and treatment response in this population differs from VL alone.  OBJECTIVES:  To evaluate factors related to an unfavorable outcome in patients with VL/HIV diagnosis in a reference center in northeast Brazil.  METHODS:  Co-infected patients, diagnosed from 2010 to 2012, were included. Data from medical records were collected until one year after VL treatment completion.  RESULTS:  Forty-two HIV-infected patients were included in the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Visceral Leishmaniasis; HIV; AIDS.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600651

Vulnerability to HIV among older men who have sex with men users of dating apps in Brazil
Provedor de dados: 55
Autores: Queiroz,Artur Acelino Francisco L.N.; Sousa,Alvaro Francisco Lopes de; Brignol,Sandra; Araújo,Telma Maria Evangelista; Reis,Renata K.
ABSTRACT  Introduction: The elderly population is increasingly benefiting from recent technological advances. In this scenario, geolocation-based dating applications provide a viable alternative for finding partners in a practical and timely manner, but may be accompanied by certain risk behaviors for HIV infection. Although there are considerable number of users over 50 on these applications, no studies have addressed this problem. The aim of the present study was to analyze factors of vulnerability to HIV/Aids among the population of men who have sex with men (MSM) age 50 years or older who use dating apps.  Methods: This was a cross-sectional, population-survey-based, analytical study, conducted exclusively online with a sample of 412 MSM. The data was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Men who have sex with men; HIV/Aids; Sexually transmitted infections; Mobile phone applications; Middle-aged men.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500298

Weight-based combination therapy with peginterferon alpha-2b and ribavirin for Naïve, relapser and non-responder patients with chronic hepatitis C
Provedor de dados: 55
Autores: Gonçales Jr.,Fernando Lopes; Vigani,Aline; Gonçales,Neiva; Barone,Antonio Alci; Araújo,Evaldo; Focaccia,Roberto; Oliveira,Umbeliana; Coelho,Henrique Sérgio Morais; Paixao,Jacqueline; Perez,Renata; Lobato,Cirley; Weirich,Judith; Rosa,Heitor; Borges,Andrelina; Vila,Ricardo; Corrêa-Giannella,Maria Lúcia; Ferraz,Maria Lúcia Gomes.
Combination therapy with pegylated interferon and ribavirin is considered the new standard therapy for naïve patients with chronic hepatitis C. We evaluated the efficacy and safety of treatment with weight-based peginterferon alpha-2b (1.5 mg/kg per week) plus ribavirin (800-1,200 mg/day) for 48 weeks in naïve, relapser and non-responder (to previous treatment with interferon plus ribavirin) patients with chronic hepatitis C. Sixty-seven naïve, 26 relapser and 40 non-responder patients were enrolled. The overall sustained virological response (SVR) for the intention-to-treat population was 54% for naïve, 62% for relapser and 38% for non-responder patients. In the naïve subgroup, SVR was significantly higher in patients with the non-1 genotype (67%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Interferon alpha-2b; Therapy.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500002

Weil's disease: an unusually fulminant presentation characterized by pulmonary hemorrhage and shock
Provedor de dados: 55
Autores: Spichler,A.; Moock,M; Chapola,E.G.; Vinetz,J.
A case of fulminant leptospirosis is presented, manifesting as rapid progression from acute undifferentiated febrile illness to refractory shock, jaundice, renal failure and massive pulmonary hemorrhage. The patient received aggressive intensive care unit support including prolonged intubation and ventilation. This case emphasizes that acute leptospirosis may well not be characterized by the classic scenario of a biphasic illness, but rather by a fulminant, monophasic illness.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Weil's Disease; Hemorrhage; Shock.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400011

Western blot seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) in Fortaleza (Brazil): a serological and molecular diagnostic and epidemiological approach
Provedor de dados: 55
Autores: Santos,Terezinha de Jesus Teixeira; Costa,Carlos Maurício de Castro; Goubau,Patrick; Vandamme,Anne-Mieke; Desmyter,Jan; Van Dooren,Sonia; Mota,Rosa M. S.; Costa,Francine Bovy de Castro; Oliveira,Ana C. S.; Gomes,Vânia Barreto A.F.; Carneiro-Proietti,Anna B.; Bruin,Veralice Meireles Sales de; Sousa,Francisca C. F. de; Oriá,Reinaldo Barreto.
How to handle Western blot (WB) seroindeterminate individuals for Human T-lymphotropic Virus 1/2 (HTLV-1/2) constitutes a challenge for blood banks and fam ilies. We made a cross-sectional study of 191 enzyme linked immunoassay (EIA) reactive individuals from the hematological center (HEMOCE) of Fortaleza (Brazil), examining their serological (WB) and molecular (PCR) diagnosis, and demographic profiles, as well as a possible association of their condition with other infectious pathologies and risk factors. Ethical institutional approval and personal consent were obtained. Out of 191 EIA reactive individuals, 118 were WB seroindeterminate and 73 were seropositive for HTLV-1/2. In the PCR analysis of 41 WB seroindeterminate individuals, 9 (22%) were positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Epidemiology; PCR; HTLV-1/2; Seroindeterminate individuals; Hepatitis; Syphilis; Blood transfusion.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000300005

What are the causes and outcomes of the coexistence of HBsAg and anti-HBs?
Provedor de dados: 55
Autores: Afyon,Murat.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300021

What do we (not) know about the human bartonelloses?
Provedor de dados: 55
Autores: Velho,Paulo Eduardo Neves Ferreira; Cintra,Maria Letícia; Uthida-Tanaka,Ana Maria; Moraes,Aparecida Machado de; Mariotto,Andréia.
The human bartonelloses are a group of diseases with a rapidly increasing clinical spectrum. Well known manifestations such as Carrion's disease, trench fever, cat-scratch disease, and bacillary angiomatosis are examples of Bartonella spp. infection. Along with these diseases, recurrent bacteremia, endocarditis, septicemia, erythema nodosum, erythema multiforme, trombocytopenic purpura and other syndromes have been reported having been caused by bacteria of this genus. The infectious process and the pathogenesis of these microorganisms are poorly understood. The bartonelloses may have a benign and self-limited evolution in a host, or a potentially fatal one. These bacteria can provoke a granulomatous or an angioproliferative histopathologic response. As...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bartonella; Carrion's disease; Trench fever; Cat-scratch disease; Bacillary angiomatosis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100001

What is the probability of a patient presenting a pleural effusion due to tuberculosis?
Provedor de dados: 55
Autores: Neves,Denise Duprat; Dias,Ricardo Marques; Cunha,Antônio José Ledo Alves da; Preza,Paulo César Amorim.
INTRODUCTION: In Rio de Janeiro, in almost half of the cases of pleural tuberculosis (PT) treatment begins without substantiation of diagnosis. We examined variables associated with this disease. METHOD: We studied 215 consecutive patients; 104 had tuberculosis (TB) and 111 did not (NTB): 41 neoplasms, 29 transudates, 28 para-pneumonic and 13 other etiologies. Clinical and laboratory variables were assessed in a combined manner using likelihood ratios (LR) and Bayes' theorem to determine the probability of PT. RESULTS: Among the variables examined, adenosine deaminase (ADA) levels, lymphocyte cell percentage, protein and age were the best indicators for the diagnosis of PT. Association of ADA with any of the other variables led to a LR+ higher than 10 and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bayes' Theorem; Tuberculosis; Pleural effusion; Adenosine deaminase and diagnosis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000400007

Widespread dissemination of multidrug-resistant Acinetobacter baumannii producing OXA-23 carbapenemase and ArmA 16S ribosomal RNA methylase in a Bulgarian university hospital
Provedor de dados: 55
Autores: Strateva,Tanya; Markova,Boyka; Marteva-Proevska,Yulia; Ivanova,Dobrinka; Mitov,Ivan.
Tipo: Info:eu-repo/semantics/other
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300020

Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil?
Provedor de dados: 55
Autores: Esposito,Danillo Lucas Alves; Fonseca,Benedito Antonio Lopes da.
Abstract Mayaro virus is an alphavirus from the Togaviridae family and is transmitted mainly by Hemagogus mosquitoes. This virus circulates in high-density tropical forests or rural areas of Central and South America causing a disease characterized by high-grade fever, maculopapular skin rash and marked arthralgia that, in some patients, can persist for long periods after infection and may be misinterpreted as chikungunya. Although only a few outbreaks involving this virus have been reported, in the last years the number of Mayaro virus infections has increased in the central and northern regions of Brazil. In this review, we describe the reported prevalence of this infection over the years and discuss the circumstances that can contribute to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mayaro virus; Alphavirus; Chikungunya virus; Epidemiology; Outbreaks.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500540

Worrisome trends in rising minimum inhibitory concentration values of antibiotics against methicillin resistant Staphylococcus aureus - Insights from a tertiary care center, South India
Provedor de dados: 55
Autores: Niveditha,Nagasundaram; Sujatha,Sistla.
ABSTRACT  INTRODUCTION:  Appearance of isolated reports of resistance to anti-methicillin-resistantStaphylococcus aureus (MRSA) drugs is worrisome underscoring the need to continuously monitor the susceptibility of clinical MRSA isolates to these drugs. Hence, the present study is conducted to determine the susceptibility of MRSA isolates to various classes of anti-MRSA drugs such as vancomycin (glycopeptide), daptomycin (lipopeptide), tigecycline (glycylcycline), and linezolid (oxazolidinone) to determine the MIC50 and MIC90 values, and to observe MIC creep over a three year period, if any, with respect to these drugs.  METHODS:  A total of 200 isolates of MRSA obtained from clinical specimens were included. MIC was determined by E-test for anti-MRSA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; VISA; MIC creep; Vancomycin.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600585

Xerostomy, dental caries and periodontal disease in HIV+ patients
Provedor de dados: 55
Autores: Cavasin Filho,Julio César; Giovani,Élcio Magdalena.
We studied xerostomy and its correlation with periodontal and dental cavity diseases in HIV patients, through measurement of salivary flow and through variables such as saliva buffer capacity, salivary pH, periodontal index, MDF index, dental carie risk and risk of periodontal disease. One hundred patients were analyzed. They were distributed into two groups: Group I (test) - 50 patients evidently HIV+, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and oral diseases, levels of T-CD4 lymphocytes, viral load and highly active antiretroviral therapy (HAART); and Group II - (control) 50 HIV- patients, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired Immune Deficiency Syndrome; HIV; Salivary flow; Xerostomy; Dental cavity; Periodontal disease.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100005

Yellow fever outbreak in Brazil, 2017
Provedor de dados: 55
Autores: Goldani,Luciano Z.
Tipo: Info:eu-repo/semantics/other
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200123

YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study
Provedor de dados: 55
Autores: Tan,You-Wen; Ge,Guo-Hong; Zhao,Wei; Gan,Jian-He; Zhao,Yun; Niu,Zhi-Lin; Zhang,Dong-Jun; Chen,Li; Yu,Xue- Jun; Yang,Li-Jun.
OBJECTIVE: This study aimed to determine the natural prevalence of variants of tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels. METHODS: A total of 1,042 antiviral treatment naïve CHB patients (including with lamivudine [LAM]) in the past year were recruited from outpatient and inpatient departments of six centers from December 2008 to June 2010. YMDD variants were analyzed using the HBV drug resistance line probe assay (Inno-Lipa HBV-DR). HBV genotypes were detected with polymerase chain reaction (PCR) microcosmic nucleic acid cross-ELISA, and HBV deoxyribonucleic acid (DNA) was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: YMDD; Mutations; Chronic hepatitis B; Anti-viral therapy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300006

Zika virus infection, a new public health challenge
Provedor de dados: 55
Autores: Campos,Gubio C.; Sardi,Silvia I.; Sarno,Manoel; Brites,Carlos.
Tipo: Info:eu-repo/semantics/other
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300001

Zika virus infection during pregnancy and microcephaly occurrence: a review of literature and Brazilian data
Provedor de dados: 55
Autores: De Carvalho,Newton Sérgio; De Carvalho,Beatriz Freitas; Fugaça,Cyllian Arias; Dóris,Bruna; Biscaia,Evellyn Silverio.
Abstract In November of 2015, the Ministry of Health of Brazil published an announcement confirming the relationship between Zika virus and the microcephaly outbreak in the Northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. The objectives of this study were to conduct a literature review about Zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. Zika virus is an arbovirus, whose main vector is the Aedes sp. The main symptoms of the infection are maculopapular rash, fever, non-purulent conjunctivitis, and arthralgia. Transmission of this pathogen occurs mainly by mosquito bite, but there are also reports...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Zika virus; Microcephaly; Aedes mosquitoes; Pregnancy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300011

Zoonotic potential of multidrug-resistant extraintestinal pathogenic Escherichia coli obtained from healthy poultry carcasses in Salvador, Brazil
Provedor de dados: 55
Autores: Lima-Filho,José Vitor; Martins,Liliane Vilela; Nascimento,Danielle Cristina de Oliveira; Ventura,Roberta Ferreira; Batista,Jacqueline Ellen Camelo; Silva,Ayrles Fernanda Brandão; Ralph,Maria Taciana; Vaz,Renata Valença; Rabello,Carlos Boa-Viagem; Silva,Isabella de Matos Mendes da; Evêncio-Neto,Joaquim.
The zoonotic potential to cause human and/or animal infections among multidrug-resistant extraintestinal pathogenic Escherichia coli from avian origin was investigated. Twenty-seven extraintestinal pathogenic E. coli isolates containing the increased survival gene (iss) were obtained from the livers of healthy and diseased poultry carcasses at two slaughterhouses in Salvador, northeastern Brazil. The antimicrobial resistance-susceptibility profiles were conducted with antibiotics of avian and/or human use by the standardized disc-diffusion method. Antimicrobial resistance was higher for levofloxacin (51.8%), amoxicillin/clavulanic acid (70.4%), ampicillin (81.5%), cefalotin (88.8%), tetracycline (100%) and streptomycin (100%). The minimum inhibitory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ExPEC; MDR strains; Increased survival gene; Experimental infections.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100009

Zoonotic spillover and emerging viral diseases – time to intensify zoonoses surveillance in Brazil
Provedor de dados: 55
Autores: Ellwanger,Joel Henrique; Chies,José Artur Bogo.
Tipo: Info:eu-repo/semantics/other
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100076

β-lactamase producing enterobacteria isolated from surveillance swabs of patients in a cardiac intensive care unit in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Vasques,Marcia Regina G; Bello,Alexandre Ribeiro; Lamas,Cristiane da Cruz; Correa,Juarez; Pereira,José Augusto Adler.
There is a high incidence of infections caused by betalactamase-producing Gram-negative microorganisms in Brazil. These organisms are of clinical and epidemiological importance, since their mobile genetic elements facilitate cross-infection. The present study was conducted in sentinel rectal swabs from patients admitted to a cardiac surgery hospital in Rio de Janeiro, from January through December 2007, in a consecutive manner. The aim of the study was to characterize the genotype and phenotype of these isolates from colonized patients. Biochemical tests, antimicrobial susceptibility tests, a confirmatory test for the expression of extended spectrum betalactamase (ESBL) production and polymerase chain reaction for the blaTEM, blaSHV, CTX-M1, Toho-1 and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polymerase chain reaction; Infection control; Enterobacteriaceae infections.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100006